Abrégé

An optical system and a method of forming the same. The optical system may include a light source configured to generate a light beam, the light beam being coherent or partially coherent. The optical system may also include a spatial light modulator configured to modulate a phase of the light beam. The optical system may further include an eyepiece for directing the modulated light beam to an eye of a viewer, the eyepiece arranged such that an optical distance between the spatial light modulator and a main plane of the eyepiece is greater than a focal length of the eyepiece. The spatial light modulator may include an active display area having a dimension of less than 2 mm.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

The invention relates to antigen-binding molecules that specifically bind to MHC Class I DLA-12 antigen. In one embodiment, the antigen-binding molecule is an antibody that specifically binds to canine MHC Class I DLA-12 antigen. Chimeric molecules of the antibody conjugated to another heterologous moiety are also provided. In one embodiment, the heterologous moiety is monomethyl auristatin E (MMAE). A method of inhibiting cancer using the antibody or the chimeric molecule thereof is also provided. In another embodiment, the antibody-MMAE conjugate suppresses tumour development in a murine model of B cell lymphoma.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux

Abrégé

Various embodiments may relate to a resonator. The resonator may include a support including a substrate portion, and a membrane portion extending from the substrate portion over a cavity. The resonator may also include a piezoelectric layer on the membrane portion. The resonator may further include an electrode on the piezoelectric layer. The substrate portion may include dopants of a first conductivity type. The membrane portion may include dopants of a second conductivity type different from the first conductivity type. A ratio of a thickness of the membrane portion to a combined thickness of the electrode and the piezoelectric layer may be above 3:1 for temperature compensation.

Classes IPC  ?

• H03H 9/13 - Moyens d'excitation, p.ex. électrodes, bobines pour réseaux se composant de matériaux piézo-électriques ou électrostrictifs
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique

Abrégé

Disclosed is an expression vector comprising a polynucleotide encoding for a glutamine synthetase with reduced activity compared to a wild type glutamine synthetase. Also disclosed are host cells, methods for preparing stable cell line, methods of producing polypeptide of interest, and kits thereof.

Classes IPC  ?

• C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

Disclosed herein are methods and treatments for cartilage degradation, wherein the method comprises administration of a therapeutic agent which inhibits the Ga1N Ac-T activation (GALA) pathway.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p.ex. arthrites, arthroses

Abrégé

The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.

Classes IPC  ?

• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour le typage de tissu ou de cellule, p.ex. sondes d’antigène leucocytaire humain [HLA]

Abrégé

The present invention relates to an electrolyte comprising lithium difluoro(oxalate)borate (LiDFOB) and a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M, a rechargeable battery comprising the electrolyte as described herein, a cathode layer, an anode layer and a separator, and a method of preparing the electrolyte as described herein, comprising the step of dissolving LiDFOB in a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M.

Classes IPC  ?

• H01M 10/0568 - Matériaux liquides caracterisés par les solutés
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
• H01M 10/0569 - Matériaux liquides caracterisés par les solvants

Abrégé

The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene. The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.

Classes IPC  ?

• C07F 9/6568 - Composés hétérocycliques, p.ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore comme uniques hétéro-atomes du cycle
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique

Abrégé

There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61F 13/08 - Bandages ou pansements; Garnitures absorbantes spécialement conçus pour les pieds ou les jambes; Coussinets pour cors; Anneaux pour cors pour comprimer les anévrismes

Abrégé

In some aspects, a set of input elements is obtained, at a rectified linear unit-activated neuron of a neural network based, on input data at the neuron. A first group and a second group of input elements are generated based on the set of input elements. The first group and the second group of input elements are associated with first weight elements and second weight elements, respectively. A first value is generated based on the first group of input elements and the first weight elements. A second value is generated based on the second group of input elements and the second weight elements. A third value and a fourth value are respectively generated based on a first operation and a second operation on the first value and the second value. An output of the neuron is generated based on the third value and the fourth value.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

There is provided a method of privacy-preserving logistic regression training based on homomorphically encrypted ciphertexts. The method includes: obtaining a first packed ciphertext comprising at least a portion of a first training data sample packed into a first vector of slots thereof for training a privacy-preserving logistic regression model; obtaining a second packed ciphertext comprising a plurality of weights of the privacy-preserving logistic regression model packed into a first vector of slots thereof; determining at least a first output probability of the privacy-preserving logistic regression model based on the first packed ciphertext and the second packed ciphertext; and updating the plurality of weights based on the first output probability. There is also provided a corresponding system for privacy-preserving logistic regression training based on homomorphically encrypted data.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.

Classes IPC  ?

• A01N 59/16 - Métaux lourds; Leurs composés
• C09D 5/14 - Peintures contenant des biocides, p.ex. fongicides, insecticides ou pesticides
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• A01N 25/12 - Poudres ou granulés
• A61K 33/06 - Aluminium, calcium ou magnésium; Leurs composés
• A61K 33/32 - Manganèse; Ses composés
• A61K 33/30 - Zinc; Ses composés
• A61K 33/26 - Fer; Ses composés
• A61K 9/50 - Microcapsules
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges

Abrégé

Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 35/00 - Agents anticancéreux
• C07K 16/46 - Immunoglobulines hybrides

Abrégé

We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules: amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.

Classes IPC  ?

• C08F 222/10 - Esters
• C08F 222/26 - Esters d'alcools non saturés
• C08F 2/06 - Solvant organique

Abrégé

A titanium-tantalum alloy having a titanium wt % ranging from 10% to 70% and wherein the titanium has a body centered cubic structure. A method of forming a titanium-tantalum alloy, the method comprising the steps of: (a) slicing a 3D CAD model of a part to be formed into a plurality of 2D image layers; (b) preparing a homogenous powder mixture of titanium powder and tantalum powder; (c) dispensing a layer of the powder mixture onto a processing bed; (d) performing powder bed fusion of the layer of the powder mixture according to one of the 2D image layers in one of: a vacuum environment and an inert gas environment; and performing steps (c) and (d) for each of the plurality of 2D image layers in succession.

Classes IPC  ?

• C22C 14/00 - Alliages à base de titane
• B33Y 10/00 - Procédés de fabrication additive
• C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B22F 1/05 - Poudres métalliques caractérisées par la dimension ou la surface spécifique des particules
• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]

Abrégé

There is provided a device for processing homomorphically encrypted data. The device includes: inter-line butterfly array blocks, each inter-line butterfly array block including inter-line modulus butterfly units, each inter-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same row of a matrix of input data points; intra-line butterfly array blocks, each intra-line butterfly array block including intra-line modulus butterfly units, each intra-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same column of the matrix of input data points; and a clock counter communicatively coupled to each inter-line butterfly array block and each intra-line butterfly array block, and configured to output a counter signal for controlling each inter-line butterfly array block and each intra-line butterfly array block to operate with single cycle initiation interval. The matrix of input data points includes columns of input data points, whereby parallel input data points derived from the homomorphically encrypted data are arranged into the columns of input data points. Furthermore, the inter-line butterfly array blocks and the intra-line butterfly array blocks are arranged in series to form a pipeline for processing the matrix of input data points.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• G06F 9/38 - Exécution simultanée d'instructions
• G06F 7/72 - Méthodes ou dispositions pour effectuer des calculs en utilisant une représentation numérique non codée, c. à d. une représentation de nombres sans base; Dispositifs de calcul utilisant une combinaison de représentations de nombres codées et non codées utilisant l'arithmétique des résidus

Abrégé

Various embodiments may relate to a piezoelectric device. The piezoelectric device may include a substrate, and a layered stacked arrangement anchored to the substrate. The layered stacked arrangement may include a piezoelectric layer. The stacked arrangement may also include a first electrode on a first side of the piezoelectric layer. The stacked arrangement may further include a second electrode on a second side of the piezoelectric layer opposite the first side. The piezoelectric layer may include a first region including one or more dipole domains of a first type, and one or more dipole domains of a second type. The first electrode may be at least partially in contact with the first region and at least partially in contact with the second region.

Classes IPC  ?

• H10N 30/20 - Dispositifs piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique, p.ex. fonctionnant comme actionneurs ou comme vibrateurs
• H10N 30/853 - Compositions céramiques
• H10N 30/076 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par dépôt de couches piézo-électriques ou électrostrictives, p.ex. par impression par aérosol ou par sérigraphie par dépôt en phase vapeur

Abrégé

The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 35/00 - Agents anticancéreux

Abrégé

There is provided a device for vascularising a cell aggregate, the device comprising: a matrix region configured to contain a gel-like matrix and cells that form a vasculature network within th ematrix region. The matrix region having at least one opening for positioning the cell aggregate therein based on a desired three-dimensional spatial location; and one or more fluidic regions configured to contain a supporting fluid that is capable of supporting vascularisation of the cell aggregate, the one or more fluidic regions being in fluid communication with the matrix region, wherein a flow passage from the one or more fluidic regions to a gel-like matrix disposed in the matrix region is configured to allow three-dimensional vascularisation around the cell aggregate and perfusion of the vasculature once formed. There is also provided a chip comprising a plurality of the device as disclosed herein and a method for vascularising a cell aggregate.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains

Abrégé

Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.

Classes IPC  ?

• H10N 30/067 - Formation d’électrodes à une seule couche de parties piézo-électriques ou électrostrictives multicouches
• H10N 30/87 - Dispositifs piézo-électriques ou électrostrictifs - Détails de structure Électrodes ou interconnexions, p.ex. connexions électriques ou bornes
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique
• H10N 30/07 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs

Abrégé

Disclosed is an expression system for an antigen binding molecule and the uses thereof.

Classes IPC  ?

• C07K 16/46 - Immunoglobulines hybrides
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

This document describes a spatial light modulator that comprises a pixel array having a plurality of pixels whereby each pixel in this array is communicatively coupled to a digital pixel circuit which are in turn all coupled to a bit-plane control circuit. The bit-plane control circuit is configured to generate, using a Pulse Code Modulation (PCM) algorithm, bit-plane signals that are used to control the sample and hold functions performed by each of the digital pixel circuits so that the pixel array may carry out its scanning function accurately and in a power efficient manner.

Classes IPC  ?

• G11C 11/418 - Circuits d'adressage
• G02F 1/133 - Dispositions relatives à la structure; Excitation de cellules à cristaux liquides; Dispositions relatives aux circuits
• G02F 1/1343 - Electrodes
• G02F 1/1368 - Cellules à adressage par une matrice active dans lesquelles l'élément de commutation est un dispositif à trois électrodes
• G09G 3/36 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante utilisant des cristaux liquides

Abrégé

There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.

Classes IPC  ?

• C08G 81/02 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p.ex. polymères séquencés au moins un des polymères étant obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carbone
• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle

Abrégé

A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.

Classes IPC  ?

• B25J 15/12 - Têtes de préhension avec des éléments en forme de doigts avec des éléments en forme de doigts flexibles
• B25J 15/10 - Têtes de préhension avec des éléments en forme de doigts avec au moins trois éléments en forme de doigts
• B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion

Abrégé

There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule. There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.

Classes IPC  ?

• C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p.ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle

Abrégé

The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

Classes IPC  ?

• C07D 491/08 - Systèmes pontés
• C07D 215/233 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 4
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 451/06 - Atomes d'oxygène
• C07D 451/14 - Composés hétérocycliques contenant des systèmes cycliques aza-8 bicyclo [3.2.1] octane, aza-9 bicyclo [3.3.1] nonane ou oxa-3 aza-9 tricyclo [3.3.1.02,4] nonane, p.ex. alcaloïdes du tropane ou du granatane, scopolamine; Leurs acétals cycliques  contenant des systèmes cycliques aza-9 bicyclo [3.3.1] nonane, p.ex. granatane, aza-2 adamantane; Leurs acétals cycliques

Abrégé

Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnie; Test des temps de réaction
• A61B 5/378 - Stimuli visuels

Abrégé

The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.

Classes IPC  ?

• C07K 14/335 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Lactobacillus (G)
• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase

Abrégé

A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.

Classes IPC  ?

• C09C 3/06 - Traitement par des composés inorganiques
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• C09D 7/40 - Adjuvants
• C09D 5/33 - Peintures réfléchissantes
• C09C 1/28 - Composés du silicium

Abrégé

Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.

Classes IPC  ?

• G01N 21/3518 - Dispositifs utilisant des techniques de corrélation à filtres de gaz; Dispositifs utilisant des techniques de modulation de la pression des gaz
• G01N 21/05 - Cuvettes à circulation de fluides

Abrégé

The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/522 - Purines, p.ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p.ex. hypoxanthine, guanine, acyclovir

Abrégé

An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.

Classes IPC  ?

• B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p.ex. avec des séparateurs électrostatiques; Ensembles ou systèmes de plusieurs centrifugeurs
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• B01D 21/26 - Séparation du sédiment avec emploi de la force centrifuge
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/26 - Inoculateur ou échantillonneur
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01D 43/00 - Séparation de particules de liquides, ou de liquides de solides, autrement que par sédimentation ou filtration

Abrégé

The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.

Classes IPC  ?

• A23D 9/04 - Traitement
• A23D 9/007 - Autres huiles ou graisses comestibles, p.ex. huiles pour cuisson caractérisées par des ingrédients autres que des triglycérides d'acides gras
• A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles, contenant une phase aqueuse, p.ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras

Abrégé

There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.

Classes IPC  ?

• G06N 3/088 - Apprentissage non supervisé, p.ex. apprentissage compétitif
• G06N 3/049 - Réseaux neuronaux temporels, p.ex. éléments à retard, neurones oscillants ou entrées impulsionnelles

Abrégé

The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis. The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.

Classes IPC  ?

• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose

Abrégé

A closure for a sample tube comprises a reaction vessel. The reaction vessel comprises: at least one microfluidic mixing channel having an inlet and an outlet; at least one reaction chamber in fluid communication with the inlet and the outlet; an inlet chamber proximate the inlet of the at least one microfluidic mixing channel for introducing a portion of a sample solution from the sample tube into the at least one reaction chamber under hydrostatic pressure; and a diffusion-control feature for limiting egress of fluid from the outlet such that the portion of the sample solution introduced to the at least one reaction chamber is partitioned from the rest of the sample solution.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• C12N 5/0735 - Cellules souches embryonnaires; Cellules germinales embryonnaires
• C12N 5/074 - Cellules souches adultes
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

A method of producing a silicalite membrane, which includes heating an aqueous solution that includes a dopant precursor and structure-directing template agents to form silicalite seeds incorporated with a dopant, depositing a buffer layer on a ceramic substrate prior to depositing the silicalite seeds on the buffer layer, contacting the ceramic substrate with a solution including the silicalite seeds to form a silicalite layer from the silicalite seeds on the ceramic substrate, and removing the structure-directing template agents to form the silicalite membrane, where the silicalite layer includes silicalite crystals incorporated with a dopant and each of the silicalite crystals has a hollow structure which forms the pores of the silicalite layer. The silicalite membrane includes a ceramic substrate having a buffer layer formed thereon, and a silicalite layer formed on the buffer layer, where the silicalite layer includes silicalite crystals incorporated with a dopant.

Classes IPC  ?

• B01D 71/02 - Matériaux inorganiques
• B01D 69/10 - Membranes sur support; Supports pour membranes
• B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
• B01D 69/04 - Membranes tubulaires

Abrégé

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

Classes IPC  ?

• C08L 79/02 - Polyamines

Abrégé

An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

Classes IPC  ?

• G01N 21/3563 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solides; Préparation des échantillons à cet effet
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
• G01N 21/359 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche

Abrégé

Various embodiments may relate to an electro-optic modulator. The electro-optic modulator may include a waveguide configured to carry optical light along a longitudinal length of the waveguide. The electro-optic modulator may also include a first electrically conductive sub-wavelength grating on a first side of the waveguide, the first electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may further include a second electrically conductive sub-wavelength grating on a second side of the waveguide opposite the first side, the second electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may be configured to modulate the optical light upon application of a potential difference between the first electrically conductive sub-wavelength grating and the second electrically conductive sub-wavelength grating based on Pockels effect.

Classes IPC  ?

• G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
• G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence

Abrégé

The present invention is in the field of molecular diagnostics and is directed to the detection of target nucleic acids in a sample using a modified CRISPR-Dx system, typically with prior amplification of the target. The modified CRISPR-Dx system comprising an engineered E174R/S542R/K548R variant of AsCas12a, wherein when get activated indiscriminately cleaves at least one detection reagent to generate signal. In one embodiment, the target nucleic acid is SARS-CoV-2 RNA.

Classes IPC  ?

• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.

Classes IPC  ?

• G06T 7/10 - Découpage; Détection de bords
• G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
• G06T 7/64 - Analyse des attributs géométriques de la convexité ou de la concavité
• G06T 7/66 - Analyse des attributs géométriques des moments d'image ou du centre de gravité
• G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p.ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]; Caractéristiques régionales saillantes
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06T 7/00 - Analyse d'image

Abrégé

There is provided a composition comprising a slurry of capsules, the capsules having shells comprising silica and said shells encapsulating phase change materials (PCM); and a cementitious binder. There is also provided a method for preparing said composition.

Classes IPC  ?

• C09K 5/02 - Substances qui subissent un changement d'état physique lors de leur utilisation
• C04B 22/06 - Oxydes; Hydroxydes
• C04B 24/04 - Acides carboxyliques; Leurs sels, anhydrides ou esters
• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p.ex. séchage, pulvérisation
• C04B 24/38 - Polysaccharides ou leurs dérivés

Abrégé

The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
• B29C 33/42 - Moules ou noyaux; Leurs détails ou accessoires caractérisés par la forme de la surface de moulage, p.ex. par des nervures ou des rainures
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).

Classes IPC  ?

• G10K 11/165 - Sélection de matériaux de particules dans une matrice
• C09D 7/61 - Adjuvants non macromoléculaires inorganiques
• C09D 7/40 - Adjuvants
• C09D 5/24 - Peintures électriquement conductrices
• C09D 163/00 - Compositions de revêtement à base de résines époxy; Compositions de revêtement à base de dérivés des résines époxy
• C09D 137/00 - Compositions de revêtement à base d'homopolymères ou de copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un hétéroc; Compositions de revêtement à base de dérivés de tels polymères
• C09D 123/08 - Copolymères de l'éthylène
• C09D 113/00 - Compositions de revêtement à base de caoutchoucs contenant des groupes carboxyle

Abrégé

There is provided a polymer or derivative thereof comprising a plurality of active amine groups in the backbone, wherein the polymer is a reaction product of a reaction between one or more bis-carbonates and one or more amine compounds having at least two terminal amino groups. Also provided are use of the polymer or derivative thereof and a method of preparing the polymer or derivative thereof.

Classes IPC  ?

• C08G 71/04 - Polyuréthanes
• C11D 11/00 - Méthodes particulières pour la préparation de compositions contenant des mélanges de détergents
• C11D 3/00 - Autres composés entrant dans les compositions détergentes couvertes par le groupe
• C11D 3/37 - Polymères
• C10M 149/14 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone faisant intervenir une réaction de condensation
• A01N 47/12 - Dérivés de l'acide carbamique, c. à d. contenant le groupe —O—CO—N; Leurs thio-analogues contenant un groupe —O—CO—N, ou un de ses thio-analogues, non directement lié à un cycle et l'atome d'azote n'étant pas un chaînon d'un hétérocycle
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• B01D 53/62 - Oxydes de carbone
• B01D 53/78 - Procédés en phase liquide avec un contact gaz-liquide
• B01D 53/14 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption

Abrégé

This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

A chemical sensor that includes a first semiconductor substrate. The chemical sensor may also include a second semiconductor substrate. The chemical sensor may further include one or more metal layers between the first semiconductor substrate and the second semiconductor substrate such that the first and second semiconductor substrates and the one or more metal layers form a cell including a cavity, the cavity having a depth of any value equal to or less than 100 μm. The chemical sensor may also include an optical source. The chemical sensor may additionally include an optical detector such that light emitted by the optical source passes through the cell to the optical detector. The first and second semiconductor substrates and the one or more metal layers may also define at least one inlet for fluid to flow into the cavity and at least one outlet for fluid to flow out of the cavity.

Classes IPC  ?

• H01L 25/16 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant de types couverts par plusieurs des groupes principaux , ou dans une seule sous-classe de , , p.ex. circuit hybrides
• G01N 21/61 - Analyseurs de gaz non dispersifs
• H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide

Abrégé

The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.

Classes IPC  ?

• A61K 31/4545 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pipampérone, anabasine
• A61L 27/24 - Collagène
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Abrégé

A method of producing a silica-based superhydrophilic film. A coating formulation is provided, where the coating formulation includes an alkali metal silicate having a substantial portion of water removed therefrom, where the alkali metal silicate has a formula of M2O·nSiO2, and where M represents an alkali metal and n is a positive real number greater than zero. Furthermore, the coating formulation and an alcohol including a curing agent are mixed, where the curing agent includes an acid or an alkaline earth metal halide. Additionally, the coating formulation is dried to form the silica-based superhydrophilic film. Furthermore, a silica-based superhydrophilic film is produced according to such a method, where the silica-based superhydrophilic film includes an amine stabilizer.

Classes IPC  ?

• C09D 183/02 - Polysilicates
• C08G 77/02 - Polysilicates
• C09D 1/04 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de substances inorganiques silicates de métaux alcalins avec des adjuvants organiques

Abrégé

A polymer having a backbone and a side unit of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide bonded thereto, where the backbone of the polymer includes at least one heterocyclic moiety. There is also provided a process for producing the polymer as defined herein as well as a flame retardant polyolefin formulation including the polymer as defined herein and a moulded article including the flame retardant polyolefin formulation as defined herein.

Classes IPC  ?

• C08G 73/06 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale de la macromolécule; Polyhydrazides; Polyamide-acides ou précurseurs similaires de polyimides
• C08K 3/32 - Composés contenant du phosphore
• C08L 23/12 - Polypropylène

Abrégé

This invention relates to a portable magnetic particle imaging (MPI) device. The portable MPI device comprises a handheld probe and a processing unit. The handheld probe comprises a main housing a first sensor coil, a second sensor coil, a transmitter coil arranged between the first and second sensor coils, and an excitation priming frame housing magnetic component and the processing unit comprises a transmitter communicatively connected to the transmitter coil and the excitation priming frame, a receiver communicatively connected to the first and second sensor coils.

Classes IPC  ?

• G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
• G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques
• A61B 5/0515 - Imagerie par particules magnétiques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

There is provided a hydrogel binder and a method of synthesizing the same. There is also provided a free-standing electrode comprising the hydrogel binder and a method of preparing the free-standing electrode comprising the hydrogel binder. There is further provided a battery comprising the free-standing electrode as defined herein.

Classes IPC  ?

• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p.ex. liants, charges
• H01M 4/131 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif Électrodes pour accumulateurs à électrolyte non aqueux, p.ex. pour accumulateurs au lithium; Leurs procédés de fabrication Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p.ex. LiCoOx
• C08L 5/04 - Acide alginique; Ses dérivés
• C08L 79/02 - Polyamines

Abrégé

Disclosed herein is a clear cell renal cell carcinoma (ccRCC) biomarker set. Also disclosed herein is a detection system using the biomarker set disclosed herein, methods of determining whether a subject has or shows recurrence of clear cell renal cell carcinoma, method of determining whether a renal mass sample is benign or malignant, method of detecting response of a subject to systemic treatment, and a kit for carrying out the same.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

There is provided a coral-like composite material comprising highly dispersed conductive metal nitride, metal carbide or metal carbonitride nanoparticles on mesoporous carbon nanosheets, and a method of preparing the same. There is also provided a coating material for a modified separator of a lithium-sulfur battery comprising the coral-like composite material as described herein, a conducting carbon material and a binder, and a method of preparing the same.

Classes IPC  ?

• C01B 32/158 - Nanotubes de carbone
• C01B 32/914 - Carbures d’un seul élément
• H01M 50/431 - Matériau inorganique
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/058 - Structure ou fabrication
• C01B 21/06 - Composés binaires de l'azote avec les métaux, le silicium ou le bore
• C01B 21/082 - Composés contenant de l'azote et des non-métaux

Abrégé

There is provided a method of forming a structure that is in contact with an object, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be in contact with the object; and (ii) crosslinking at least part of the flowable precursor that is in contact with the object to form a structure that is in contact with the object, wherein a top surface of the part of the flowable precursor that is to be crosslinked, is in interface with a fluid medium. Also provided is a system for performing the method.

Classes IPC  ?

• B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/06 - Titane ou alliages de titane
• B29C 64/245 - Plates-formes ou substrats
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

The present disclosure generally relates to a method of fabricating a graded metallic structure by additive manufacturing and the graded metallic structure thereof. The method comprises preparing a material powder in a supply container, the material powder is partitioned into a plurality of longitudinal volumes and comprises different metallic powders, performing an additive manufacturing process comprising supplying layers of the material powder from the supply container, displacing the layers of material powder to a fabrication platform and fusing the layers of material powder on the fabrication platform to form the graded metallic structure, wherein at least one longitudinal volume has a varying transverse cross-sectional area and at least one longitudinal volume has a varying longitudinal cross-sectional area, such that the fused metallic powders in the graded metallic structure are graded along the longitudinal and the transverse. This method is proven to be effective to make graded metal parts with composition gradients in two dimensions.

Classes IPC  ?

• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
• B22F 10/38 - Commande ou régulation des opérations pour obtenir des caractéristiques spécifiques du produit, p.ex. le lissage de la surface, la densité, la porosité ou des structures creuses
• B22F 10/37 - Commande ou régulation des opérations des caractéristiques du lit de poudre, p.ex. de la densité
• B22F 1/00 - Poudres métalliques; Traitement des poudres métalliques, p.ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
• B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p.ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation
• B22F 9/04 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau solide, p.ex. par broyage, meulage ou écrasement à la meule

Abrégé

Abstract: Various embodiments may relate to a power module package. The power module package may include a power module including a first lead frame, a second lead frame, and at least one chip at least partially between the first lead frame and the second lead frame. The power module package may also include a first heat spreader attached to the first lead frame. The power module package may further include a second heat spreader also attached to the first lead frame such that the first lead frame, the first heat spreader and the second heat spreader form an enclosure defining a cavity containing the at least one chip. The enclosure may include an inlet configured to allow a cooling medium to flow into the cavity and an outlet configured to allow the cooling medium to flow out of the cavity.

Classes IPC  ?

• H01L 25/18 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant de types prévus dans plusieurs sous-groupes différents du même groupe principal des groupes , ou dans une seule sous-classe de ,
• H01L 23/495 - Cadres conducteurs
• H01L 23/367 - Refroidissement facilité par la forme du dispositif
• H01L 23/427 - Refroidissement par changement d'état, p.ex. caloducs
• H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
• H01L 25/00 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide

Abrégé

The present disclosure provides a pharmaceutical composition comprising an Agrin fragment or derivative thereof, and uses of the pharmaceutical composition. The present disclosure also provides method of producing the pharmaceutical composition.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Abrégé

The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 35/00 - Agents anticancéreux
• A61K 49/00 - Préparations pour examen in vivo
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

Disclosed is a method for assessing the transduction efficiency and/or specificity of vectors at single cell level.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN

Abrégé

The present invention relates to a soluble dimeric fusion protein comprising a first and second polypeptides, wherein the first and second polypeptides each comprises a Dectin-1 receptor polypeptide fused to a human Fc domain via a dimerization linker. Methods of using the soluble dimeric fusion protein for immunizing a subject against a fungal infection, preventing or treating a fungal infection in a subject and detecting a fungal infection in a subject are also provided. In one embodiment, a chimeric molecule comprising the fusion protein and a payload is provided. In one embodiment, the payload is Amphotericin B.

Classes IPC  ?

• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

A method for forming a transition metal dichalcogenide monolayer, which includes depositing a transition metal, a transition metal oxide, or a mixture thereof, on a substrate, introducing a chalcogen precursor to the transition metal, the transition metal oxide, or the mixture thereof, in the presence of an etching gas and a carrier gas at a first temperature, to form a transition metal dichalcogenide on the substrate from the transition metal, the transition metal oxide, or the mixture thereof, and subliming the transition metal dichalcogenide on the substrate in the presence of a pulsating supply of a vapor of the chalcogen precursor to form the transition metal dichalcogenide monolayer at a second temperature, wherein the vapor of the chalcogen precursor comprises a chalcogen vapor.

Classes IPC  ?

• C23C 16/02 - Pré-traitement du matériau à revêtir
• C23C 14/18 - Matériau métallique, bore ou silicium sur d'autres substrats inorganiques
• C23C 14/08 - Oxydes
• C23C 16/448 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour produire des courants de gaz réactifs, p.ex. par évaporation ou par sublimation de matériaux précurseurs
• C23C 16/30 - Dépôt de composés, de mélanges ou de solutions solides, p.ex. borures, carbures, nitrures
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
• C23C 16/46 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour le chauffage du substrat
• C23C 14/58 - Post-traitement
• C23C 28/00 - Revêtement pour obtenir au moins deux couches superposées, soit par des procédés non prévus dans un seul des groupes principaux , soit par des combinaisons de procédés prévus dans les sous-classes et
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives

Abrégé

A light-acoustic system and method for detecting an anomaly in a structure are provided. The system includes a light source configured to emit an excitation light and at least one excitation element attached to a surface of a structure. The at least one excitation element includes a photostrictive material and is configured to receive the excitation light for generating an oscillating strain. The oscillating strain generates an acoustic wave in the structure. The system also includes a detector configured to detect the acoustic wave.

Classes IPC  ?

• G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
• G01N 29/04 - Analyse de solides

Abrégé

A grid and skin assembly for use in a composite laminate structure is described. The assembly includes a metallic grid having a plurality of intersecting ribs oriented in at least two distinct rib directions offset at a grid angle relative to one another and defining respective intersection points; and a composite laminate skin having a plurality of ply layers comprising a plurality of tapes oriented in at least two distinct tape directions offset at a ply angle relative to one another. The grid angle is at least 25 degrees, the intersection points define glueless joints of the metallic grid, and the grid is a non-aluminum-based material. A grid and method of manufacturing the grid and skin assembly is also described. The method includes a water jet cutting procedure and glueless joint formation due to differing thermal expansion characteristics of the grid and skin.

Classes IPC  ?

• B32B 3/26 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche comportant des cavités ou des vides internes
• B32B 3/12 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche discontinue, c. à d. soit continue et percée de trous, soit réellement constituée d'éléments individuels caractérisés par une couche d'alvéoles disposées régulièrement, soit formant corps unique dans un tout, soit structurées individuellement ou par assemblage de bandes indépendantes, p.ex. structures en nids d'abeilles
• B32B 3/06 - Caractérisés par des caractéristiques de forme en des endroits déterminés, p.ex. au voisinage des bords pour attacher le produit à quelque chose d'autre p.ex. à un support
• B32B 3/08 - Caractérisés par des caractéristiques de forme en des endroits déterminés, p.ex. au voisinage des bords caractérisés par des éléments ajoutés à des endroits déterminés
• B32B 7/03 - Produits stratifiés caractérisés par la relation entre les couches; Produits stratifiés caractérisés par l’orientation relative des éléments caractéristiques entre les couches, ou par les valeurs relatives d’un paramètre mesurable entre les couches, c. à d. produits comprenant des couches ayant des propriétés physiqu; Produits stratifiés caractérisés par la jonction entre les couches concernant l’orientation des éléments caractéristiques
• B32B 15/18 - Produits stratifiés composés essentiellement de métal comportant du fer ou de l'acier
• B32B 38/00 - Opérations auxiliaires liées aux procédés de stratification

Abrégé

A method of synthesizing a polymeric clay composition for coating. A clay-polyacrylate composite is produced, where the clay-polyacrylate composite includes one or more layers of clay intercalated with polyacrylate, where the one or more layers of clay include at least one organosilane coupling agent including an acrylate moiety, where the at least one organosilane coupling agent is attached to a surface of the one or more layers of clay and the polyacrylate is covalently attached to the organosilane coupling agent, and where the polyacrylate consists of a first acrylate monomer and a second acrylate monomer having different solubility, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water. Furthermore, the clay-polyacrylate composite is mixed with a solution including a polymer to form the polymeric clay composition.

Classes IPC  ?

• C09D 133/14 - Homopolymères ou copolymères d'esters d'esters contenant des atomes d'halogène, d'azote, de soufre ou d'oxygène en plus de l'oxygène du radical carboxyle
• C08F 292/00 - Composés macromoléculaires obtenus par polymérisation de monomères sur des substances inorganiques
• C08F 2/44 - Polymérisation en présence d'additifs, p.ex. plastifiants, matières colorantes, charges
• C08F 2/18 - Polymérisation en suspension
• C08K 5/14 - Peroxydes
• C08K 5/5425 - Composés contenant du silicium contenant de l'oxygène contenant au moins une liaison C=C
• C08K 9/04 - Ingrédients traités par des substances organiques
• C08K 3/34 - Composés contenant du silicium
• C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique

Abrégé

A method for determining the health status of an elderly individual by testing the sample extracted from the individual for the presence of biomarkers, the bio markers being autoantibodies to antigens comprising MAPK13, CD96, FKBP3, PPM1A, PHLDA1, GLRX3, FEN1 and AURKA, wherein the antigens may further comprise one or more of UBE2I, AAK1, YARS, ASPSCR1, CASP10, FHOD2, TCL1A and MAP4, wherein PHLDA1 and CD96 correspond to healthy, AURKA, FEN1, CASP10 and AAK1 correspond to intermediate health, and UBE2I, YARS, ASPSCR1, FHOD2, TCL1A, MAP4, MAPK13, FKBP3, PPM1A and GLRX3 correspond to unhealthy.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

There is provided a microfluidic device comprising a first region configured to hold target cells, e.g., tumor cells, a second region configured to hold effector cells, e.g., immune cells, and an array of microstructures disposed between the first and second regions, wherein the first region is in fluid communication with the second region, and wherein the array of microstructures is configured to selectively allow movement of immune cells, from the second region to an interaction zone that is at least partially disposed within the first region, for interaction with tumor cells in the interaction zone. The array of microstructures can be an array of micropillars. Also provided is a chip comprising a plurality of the device and a method of studying interactions of a first cell type with a second cell type.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

There is provided a method of identifying a neutrophil progenitor, the method comprising: determining an expression of at least one biomarker selected from the group consisting of: CD71, LOX-1, CD164, CD112, CD181, TACSTD2, CD11b and CD49d in a cell. In various embodiments, the cell is identified as a neutrophil progenitor when it is determined to have at least one of the following expression profiles: CD71hi/+, LOX-1int/lo/−, CD164hi/+, CD112hi/+, CD181int/lo/−, TACSTD2hi/+, CD11blo/− and/or CD49dint/hi/+. Also disclosed are a method of sorting and/or separating neutrophil progenitors from a cell population, a composition that is enriched in neutrophil progenitors and related uses and methods.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

A method of synthesizing a clay-polyacrylate composite. An aqueous solution including clay is mixed with at least one organosilane coupling agent including an acrylate moiety to form a silanized-clay suspension. The silanized-clay suspension is contacted with a first acrylate monomer and a second acrylate monomer in an inert environment, where the first acrylate monomer and the second acrylate monomer have different solubility. A polymerization initiator is added to the silanized-clay suspension before or during the contacting of the silanized-clay suspension with the first acrylate monomer and the second acrylate monomer in the inert environment to form the clay-polyacrylate composite including the first and second acrylate monomer, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water.

Classes IPC  ?

• C09D 133/14 - Homopolymères ou copolymères d'esters d'esters contenant des atomes d'halogène, d'azote, de soufre ou d'oxygène en plus de l'oxygène du radical carboxyle
• C08F 292/00 - Composés macromoléculaires obtenus par polymérisation de monomères sur des substances inorganiques
• C08F 2/44 - Polymérisation en présence d'additifs, p.ex. plastifiants, matières colorantes, charges
• C08F 2/18 - Polymérisation en suspension
• C08K 5/14 - Peroxydes
• C08K 5/5425 - Composés contenant du silicium contenant de l'oxygène contenant au moins une liaison C=C
• C08K 9/04 - Ingrédients traités par des substances organiques
• C08K 3/34 - Composés contenant du silicium
• C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique

Abrégé

A spatial light modulator and a method for forming the spatial light modulator. The spatial light modulator may include a first reflector. The spatial light modulator may also include a second reflector. The spatial light modulator may further include a liquid crystal layer between the first reflector and the second reflector. The first reflector may include a first electrode. The second reflector may include a second electrode. At least one reflector selected from the first reflector and the second reflector may be or may include a distributed Bragg reflector (DBR). The first reflector and the second reflector may form a Fabry-Perot (FP) cavity.

Classes IPC  ?

• G02F 1/1335 - Association structurelle de cellules avec des dispositifs optiques, p.ex. des polariseurs ou des réflecteurs

Abrégé

A system for monitoring foetal growth. The system may include a plurality of devices. Each device of the plurality of devices may be configured to determine measurements of a baby bump over a time period, and may be further configured to store the measurements. The system may also include a server configured to receive the measurements from each of the plurality of devices. The server may be configured to compare the measurements from different devices of the plurality of devices. The system may be further configured to send an alert upon detecting an abnormality based on the measurements from the different devices of the plurality of devices.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

Classes IPC  ?

• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

Disclosed is an apparatus for disinfection comprising a cylindrical housing; a plurality of ultra-violet light emitting diode (UV-LED) modules disposed on the circumference of the cylindrical housing, each UV-LED module comprising a heat sink; and a heat dissipation module disposed along the central axis of the cylindrical housing, the heat dissipation module arranged in thermal contact with the heat sink of each of the plurality of UV-LED modules; wherein each of the plurality of UV-LED modules is pivotably mounted onto the circumference.

Classes IPC  ?

• A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
• A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contact; Accessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets

Abrégé

The present invention provides methods, antibodies and kits for detecting and/or quantifying expression of both non-nucleic acid molecules, such as proteins, and nucleic acid molecules in a single sample or single cell. The antibody is covalently conjugated to an oligonucleotide, such as a single-stranded DNA molecule, which comprises an identification tag and a blocking group, such as a ddNTP or an inverted dTTP, which prevents extension of the oligonucleotide by a polymerase. The method comprises the steps of reverse transcribing the conjugated oligonucleotide and the target nucleic acid simultaneously, amplifying both transcription production, and detecting the amplicons thereof. The method is also useful for detecting and/or quantifying the number of cells in a sample expressing a given non -nucleic acid molecule (e.g. protein).

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet

Abrégé

There is provided a method of identifying pro-inflammatory dendritic cells, the method comprising: determining an expression of CD5, CD14 and/or CD163 in cells, wherein CD5−, CD14+ and/or GD163+ cells are identified as pro-inflammatory dendritic cells. Also disclosed is a method of characterising inflammation and/or inflammatory disease in a subject, the method comprising: determining a proportion of CD5−, CD14+ and/or GD163+ dendritic cells in the subject's sample, wherein the proportion positively correlates with the level of inflammation and/or the severity of inflammatory disease in the subject.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present invention relates, in general terms, to hydrogels and their uses thereof. The hydrogels demonstrate toughness; i.e. the ability to absorb energy and plastically deform without fracturing. The present invention also relates to methods of fabricating hydrogels. In particular, the method of fabricating a tough hydrogel comprises polymerising a plurality of charged monomers in the presence of multivalent ions in order to form an ion impregnated hydrogel and exposing the ion impregnated hydrogel to heat in order to form the tough hydrogel.

Classes IPC  ?

• C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
• C08F 2/46 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire
• C08F 2/28 - Polymérisation en émulsion utilisant des agents émulsifiants cationiques
• C08F 2/44 - Polymérisation en présence d'additifs, p.ex. plastifiants, matières colorantes, charges
• C08F 222/38 - Amides

Abrégé

This disclosure relates to a current-to-digital converter suitable for wide-ranging current sensing applications. In particular, the current-to-digital converter comprises a delta-sigma analogue-to-digital converter which utilizes a successive-approximation-register to control a modulation of the sensed current so that the digital conversion of the modulated sensed current by the delta-sigma analogue-to-digital converter may be done with high precision.

Classes IPC  ?

• H03M 1/46 - Valeur analogique comparée à des valeurs de référence uniquement séquentiellement, p.ex. du type à approximations successives avec convertisseur numérique/analogique pour fournir des valeurs de référence au convertisseur
• H03M 3/00 - Conversion de valeurs analogiques en, ou à partir d'une modulation différentielle

Abrégé

A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

Classes IPC  ?

• G01N 21/65 - Diffusion de Raman

Abrégé

The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

Classes IPC  ?

• C07D 473/06 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés en position 1 ou 3
• A61K 31/522 - Purines, p.ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p.ex. hypoxanthine, guanine, acyclovir
• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• C07D 473/08 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés en position 1 ou 3 avec des radicaux méthyle en positions 1 et 3, p.ex. théophylline

Abrégé

The present application discloses methods useful for the multiplex measurement of enzymatic activities. Also disclosed are polynucleotide constructs, constructs libraries and compartments related suitable for use in the methods.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 9/22 - Ribonucléases
• C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
• C40B 40/08 - Bibliothèques comprenant de l'ARN ou de l'ADN codant des protéines, p.ex. bibliothèques de gènes

Abrégé

The present invention provides a method of prophylaxis or treatment of airway inflammation and/or related complications triggered by Enterovirus 3C protease-activated NLRP1, a compound or composition comprising said compound for use in the method, and use of said compounds in medicament preparation for the prophylaxis or treatment of human airway inflammation and/or related complications triggered by Enterovirus 3C protease-activated NLRP1.

Classes IPC  ?

• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/7064 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides  contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées
• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61K 38/06 - Tripeptides
• A61K 31/69 - Composés du bore
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and/or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p.ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

The present invention relates, in general terms, to piezoelectric thin films with an empirical formula (K1xNax)yNbO3, wherein 0≤x≤1 and 0.64≤y≤0.95. In particular, the piezoelectric thin film comprises at least two adjacent NbO2 planes in an antiphase boundary, the at least two adjacent NbO2 planes displaced from each other by about half a lattice length in either the (100), (010) or (100) crystallographic plane. The present invention also relates to methods of fabricating the piezoelectric thin films.

Classes IPC  ?

• C01G 33/00 - Composés du niobium
• H10N 30/00 - Dispositifs piézo-électriques ou électrostrictifs
• H10N 30/853 - Compositions céramiques
• H10N 30/076 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par dépôt de couches piézo-électriques ou électrostrictives, p.ex. par impression par aérosol ou par sérigraphie par dépôt en phase vapeur

Abrégé

The present invention relates to signalling catalytic nucleic acid nanostructures that are responsive to polymerase activity, methods of their use, devices and kits comprising the same. More specifically, the present invention provides a catalytic signalling nanostructure comprising a DNAzyme/RNAzyme, such as G-quadruplex hemin, and a polymerase—responsive element. Polymerase elongation of the polymerase-responsive element eliminates catalytic activity of the DNAzyme/RNAzyme. The catalytic nucleic acid nanostructure can be used alone or paired with a target recognition nanostructure which can transduce molecular signals into polymerase activity, in an integrated circuit.

Classes IPC  ?

• C12Q 1/682 - Amplification du signal
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p.ex. kinases (2.7)

Abrégé

The invention relates to treating a plant-based material with an agent and/or a force to enable the plant-based material to mimic the colour of animal products, wherein the agent and/or force is capable of controlled permeabilisation of cell membrane to thereby release polyphenols from the cells of the plant-based material to allow polyphenol-cell wall interaction and/or causes the oxidation of polyphenols in the plant-based material. Also disclosed is a plant-based food product, such as plant-based meat substitutes, produced by the process thereof.

Classes IPC  ?

• A23J 3/14 - Protéines végétales
• A23L 5/40 - Coloration ou décoloration des aliments
• A23J 3/22 - Traitement des protéines pour l'alimentation par texturation

Abrégé

There is provided a lighting system comprising a light source, and a cooling system with temperature sensing and responding capability coupled to the light source for maintaining a temperature of the light source within a defined variation from a set temperature. There are also provided a method of adjusting a temperature of a light source and a method of assembling the lighting system. There is further provided an additive manufacturing system for three-dimensional printing comprising the lighting system.

Classes IPC  ?

• H05K 7/20 - Modifications en vue de faciliter la réfrigération, l'aération ou le chauffage
• B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p.ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
• B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet

Abrégé

There is provided a method of synthesizing a single-stranded nucleotide sequence, the method comprising adding a blocked nucleoside triphosphate to an initiator nucleotide sequence to incorporate a corresponding blocked nucleotide thereto in the presence of a polymerase, wherein the blocked nucleoside triphosphate has one of the general formulae (I), (II), (III), (IV), (V) and (VI).

Classes IPC  ?

• C07H 1/00 - Procédés de préparation des dérivés du sucre
• C07H 19/10 - Radicaux pyrimidine avec le radical saccharide estérifié par des acides phosphoriques ou polyphosphoriques
• C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques

Abrégé

A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

Classes IPC  ?

• A61K 31/795 - Polymères contenant du soufre
• C08G 64/02 - Polycarbonates aliphatiques
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

We describe a method of diagnosis of a dermatological condition such as atopic dermatitis (AD) in an individual. The method comprises detecting the activity or expression level of miR-335 in a sample of or from an individual. We also disclose the use of a histone deacetylase (HDAC) inhibitor such as belinostat (PubChem CID: 6918638) in the preparation of a medicament for the restoration of barrier function or for the treatment of a dermatological condition such as atopic dermatitis.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c. à d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester 
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61K 31/18 - Sulfamides
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

This invention relates to a resin composition comprising at least one of a first monomeric or oligomeric component (A), at least one of a second monomeric or oligomeric component (B) and a photoinitiator. This invention also relates to a method of preparing a polymer from the resin composition, a polymer prepared from the resin composition, a method of forming a 3-dimensional printed article, and a kit comprising at least one of a first monomeric or oligomeric component (A), at least one of a second monomeric or oligomeric component (B) and a photoinitiator.

Classes IPC  ?

• C08L 33/10 - Homopolymères ou copolymères des esters de l'acide méthacrylique
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive

Abrégé

A method of producing a porous carbon composite fibrous mats formed of a network of carbon fibers incorporated with porous carbon particles. The method includes electrospinning a polymer solution to form a porous layer of polymeric fibers and the polymeric fibers are doped with a precursor of conductive metal particles, where the polymer solution includes a polymer and the precursor of the conductive metal particles, electrospraying a metal organic framework suspension onto the porous layer of polymeric fibers, where the metal organic framework suspension includes metal organic framework particles, repeating the electrospinning and electrospraying in an alternating manner to form a porous network of polymeric fibers incorporated with the metal organic framework particles, and heating the porous network of polymeric fibers incorporated with the metal organic framework particles to form the porous carbon composite fibrous mats.

Classes IPC  ?

• B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
• B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
• C02F 1/467 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par désinfection électrochimique

Abrégé

The present invention relates to a method and system for introducing one or more exogenous substances into an immune cell. The method comprises the steps of: providing a membrane having a plurality of pores configured to allow the immune cell to pass through, wherein the plurality of pores has an average pore diameter which is no less than an average diameter of the immune cell nucleus and no more than an average diameter of the immune cell, passing a fluid containing the immune cell and the on e or more exogenous substances through the plurality of pores to induce a mechanical stress to the immune cell and facilitate introduction of the one or more exogenous substances into the immune cell, and recirculating the fluid containing the immune cell and the one or more exogenous substances such that the same immune cell passes through the membrane more than once. In some embodiments, the immune cell is T-cells and the exogenous substance is mRNA.

Classes IPC  ?

• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation
• C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

Abrégé

Various embodiments may relate to a tunable optical device. The tunable optical device may include a ferroelectric layer including a ferroelectric material. The tunable optical device may also include one or more first electrodes on a first side of the ferroelectric layer. The tunable optical device may further include one or more second electrodes on a second side of the ferroelectric layer opposite the first side. A refractive index of the ferroelectric material may be changeable in response to a potential difference applied between the one or more first electrodes and the one or more second electrodes. The one or more first electrodes and the one or more second electrodes may be configured to allow visible light or infrared light to pass through.

Classes IPC  ?

• G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c. à d. déflexion

Abrégé

There is provided a method of communication between functional blocks in a system-on-chip. The method includes: exchanging a respective public key between a first functional block and a second functional block in the system-on-chip (SoC) for a communication therebetween, the first functional block being a transmitter of the communication and the second function block being a receiver of the communication; generating, at the first functional block, a first code based on the public key of the second functional block; generating, at the second functional block, a second code based on the public key of the first functional block; obfuscating, at the first functional block, an address associated with the communication based on the first code to produce an obfuscated address; transmitting, at the first functional block, the obfuscated address to the second functional block via an interconnect communication infrastructure in the system-on-chip; receiving, at the second functional block, the obfuscated address from the first functional block via the interconnect communication infrastructure; and deobfuscating, at the second functional block, the obfuscated address received based on the second code to produce a deobfuscated address associated with the communication. There is also provided a corresponding system-on-chip.

Classes IPC  ?

• H04L 9/08 - Répartition de clés
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/12 - Dispositifs de chiffrement d'émission et de réception synchronisés ou initialisés d'une manière particulière

Abrégé

This invention relates to a a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0 wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (ERA), β-carboxyethyl acrylate (β-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (β-EHA), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications. The invention also relates to methods for making silane modified clay usable in the process for making the suspensions.

Classes IPC  ?

• C08F 20/06 - Acide acrylique; Acide méthacrylique; Leurs sels métalliques ou leurs sels d'ammonium
• C09D 133/02 - Homopolymères ou copolymères d'acides; Leurs sels métalliques ou d'ammonium
• C08J 7/04 - Revêtement
• C08J 7/043 - Amélioration de l'adhésivité des revêtements en soi, p.ex. par formation d'apprêts
• C08F 2/44 - Polymérisation en présence d'additifs, p.ex. plastifiants, matières colorantes, charges
• C09D 4/06 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable en combinaison avec un composé macromoléculaire autre qu'un polymère non saturé des groupes
• C08J 7/048 - Formation de revêtements formant une barrière aux gaz