Abrégé

The invention relates to a method for decellularization of tissue samples to produce decellularized extracellular matrix (dECM) by performing one or more wash cycles in a reactor using a reagent after at least partially submerging the tissue sample in the reagent, wherein the reactor comprising a tissue chamber in fluid communication with a reactor chamber. The method further comprising the steps of agitating the tissue sample and/or the reagent such that the tissue sample circulates in the reagent while retaining the tissue sample in a tissue chamber or a decellularization reactor, monitoring at least one parameter of the reagent and/or at least one parameter of the tissue sample, and adjusting one or more wash cycles based on said monitoring. The invention further relates to a decellularization reactor and a decellularization system for decellularizing a tissue sample.

Classes IPC  ?

• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels

Abrégé

This disclosure relates to a method of amplification of a target nucleic acid, the method comprising subjecting the target nucleic acid to one or more amplification step in the presence of a mixture comprising a control nuclei acid, a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the target nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3′ end. In one embodiment, the target nucleic acid is cell-free RNA and the method comprises annealing the target nucleic acid and performing a reverse transcription prior to the one or more amplification step. Also disclosed are nucleic acid amplification mixtures, kits for amplifications, and methods of detecting and/or determining the presence and/or the amount of a target nucleic acid.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes

Abrégé

There is provided herein a paper-based sensor for simultaneously determining a plurality of biomarkers present in a biological sample comprising a plurality of detection zones in fluid communication with a sampling zone, wherein said plurality of detection zones comprises sensing material specific to each of said plurality of biomarkers. There is also provided herein a method of manufacturing the paper-based sensor, a use of a paper-based sensor for wound diagnosis, a kit comprising the paper-based sensor and a method of diagnosing wound health.

Classes IPC  ?

• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• G01N 33/84 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des composés inorganiques ou le pH

Abrégé

This disclosure relates to a method of assessing/monitoring the health of a subject, the method comprising subjecting a pancreas-associated polynucleotide to one or more amplification step in the presence of a mixture comprising a control nuclei acid, a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the target nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3′ end. In one embodiment, the pancreas-associated polynucleotide is cell-free RNA and the method comprises annealing the target nucleic acid and performing a reverse transcription prior to the one or more amplification step. Also disclosed are primer and/or primer sets as disclosed herein and kits for use thereof.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to isolated and engineered human antibodies that specifically bind to at least one conformational (non-linear) epitope of HBsAg and neutralize hepatitis B virus infection, methods for producing the same, and uses thereof in treating human HBV infection.

Classes IPC  ?

• C07K 16/08 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/20 - Antiviraux pour le traitement des virus ADN
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present disclosure relates to functionalised polypeptides, nanoparticles and their 5 uses thereof. The functionalised polypeptide comprises polylysine functionalised with guanidinium moieties, wherein the polypeptide is about 50% to about 98% functionalised. The number of guanidinium functionalised lysine monomeric units is 5 to 100, and the number of lysine monomeric units is 1 to 50. The functionalised polypeptides and nanoparticles can be used for treating a microbial infection or for 10 treating cancer.

Classes IPC  ?

• C07K 14/01 - Virus à ADN
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 35/00 - Agents anticancéreux

Abrégé

The present disclosure generally relates to a flow reactor system (100) and a flow reaction method (200). The flow reactor system (100) comprises liquid pumps (110) for communicating liquid reagents based on a set of flow conditions, a fluid pump (200) for communicating a carrier fluid that is immiscible with the liquid reagents; a fluidic mixer (130) for mixing the liquid reagents into a liquid mixture, a measurement device (150) for measuring properties of liquid plugs (140) discharged from an outlet (136) of the fluidic mixer (130); and a control module configured for controlling the liquid pumps (110) and adjusting the flow conditions based on the measured properties of the liquid plugs (140), wherein the liquid plugs (140) are representative of different flow conditions.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
• B01J 4/00 - Dispositifs d'alimentation; Dispositifs de commande d'alimentation ou d'évacuation
• B01J 14/00 - Procédés chimiques généraux faisant réagir des liquides avec des liquides; Appareillage spécialement adapté à cet effet
• B01J 19/24 - Réacteurs fixes sans élément interne mobile
• B29C 64/314 - Préparation
• B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B33Y 40/00 - Opérations ou équipements auxiliaires, p.ex. pour la manipulation de matériau
• B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive

Abrégé

This technology relates to a method of isolating adipose-derived cell lines from an animal, a method of isolating adipocytes from an animal, and isolated adipose-derived cell lines thereof.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p.ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires

Abrégé

An Advanced Encryption Standard (AES) device and a computer-implemented method of performing an AES operation may be provided, the AES device comprising a state array of components comprising a first plurality of controllable data processing components, the first plurality of controllable data processing components including two or more controllable data processing state members that each include an additional input control and an additional input port; a key array of components comprising a second plurality of controllable data processing components; a control block module coupled to the state array of components and the key array of components, the control block module arranged to transmit one or more control signals to the state array of components and the key array of components; wherein the two or more controllable data processing state members are disposed at predetermined positions within the state array of components; and further wherein the control block module is arranged to instruct performance of one or more AES operations via usage of the additional input port of at least one of the two or more controllable data processing state members based on a clock cycle count.

Classes IPC  ?

• H04L 9/06 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p.ex. système DES

Abrégé

A method of forming a transition metal dichalcogenide layer on a substrate is provided. The method may include providing a transition metal oxide, a chalcogen source, a non-gaseous chalcogen scavenger, and a substrate, wherein the substrate is disposed downstream of the transition metal oxide and the chalcogen source, and wherein the non-gaseous chalcogen scavenger is disposed in proximity to the transition metal oxide; generating vapors of the transition metal oxide and vapors of the chalcogen source, wherein the non-gaseous chalcogen scavenger reacts preferentially with the vapors of the chalcogen source; disposing the vapors generated from the transition metal oxide and the chalcogen source on the substrate; and reacting the vapors of the transition metal oxide and the chalcogen source on the substrate to obtain the transition metal dichalcogenide layer on the substrate. An arrangement for forming a transition metal dichalcogenide layer on a substrate is also provided.

Classes IPC  ?

• C23C 16/30 - Dépôt de composés, de mélanges ou de solutions solides, p.ex. borures, carbures, nitrures
• C23C 16/44 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement
• C23C 16/448 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour produire des courants de gaz réactifs, p.ex. par évaporation ou par sublimation de matériaux précurseurs
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction

Abrégé

A method of forming a titania-coated inorganic particle comprising the steps of: (a) agitating a mixture of inorganic particle and organic solvent; (b) adding titania precursor dropwise into the mixture of step (a) under agitation; and (c) adding catalyst to the mixture of step (b) thereby converting said titania precursor to titania which then forms a coating on said inorganic particle; wherein steps (a) to (c) are performed at neutral pH and ambient temperature.

Classes IPC  ?

• C09C 3/06 - Traitement par des composés inorganiques
• A01N 25/12 - Poudres ou granulés
• A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• B01J 21/06 - Silicium, titane, zirconium ou hafnium; Leurs oxydes ou hydroxydes
• B01J 21/08 - Silice
• B01J 35/39 - Propriétés photocatalytiques
• C03C 12/02 - Billes réfléchissantes
• C03C 17/25 - Oxydes par dépôt à partir d'une phase liquide
• C09C 1/00 - Traitement de substances inorganiques particulières, autres que des charges fibreuses ; Préparation du noir de carbone
• C09D 5/32 - Peintures absorbant les radiations
• C09D 5/33 - Peintures réfléchissantes
• C09D 7/40 - Adjuvants
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés

Abrégé

The invention relates generally to the field of biochemistry. In particular, the invention relates to a method of detecting or measuring target that is bound to a ligand in a sample, the method comprising contacting a sample comprising one or more cells with a cell-permeable denaturant to promote intracellular unfolding of the target in the sample, followed by lysing the sample. The lysed sample is then detected or measured for the level of non-aggregated target or aggregated target, wherein a difference in the level of non-aggregated target or aggregated target as compared to a reference indicates the presence or level of target that is bound to the ligand in the sample. In specific embodiments, the cell-permeable denaturant is urea or derivatives thereof. Methods of identifying a candidate ligand or predicting the efficacy of a drug in a subject are also provided therein.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to a method for assessing and evaluating the potential effect of therapeutics on an individual. In particular, the invention uses real-time PCR-based pharmacogenomic assays in assessing such potential effects. In an aspect of the present invention, there is provided a method of assessing or evaluating a subject's likelihood of developing an adverse reaction in response to an administration of a therapeutic agent, or a method of assessing or evaluating a therapeutic agent's efficacy on a subject, the method comprising determining in a single real-time polymerase chain reaction run the presence of a variant in a set of genes consisting of CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 in a sample obtained from the subject, wherein the presence of a variant on any one of the genes in the set of genes is indicative of a risk to an adverse reaction and/or a change in efficacy to the therapeutic agent.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

There is provided a neural network processor system including: a neural processing unit including a plurality of neural processing cores; a router network including a plurality of routers communicatively coupled to the plurality of neural processing cores, respectively; and a host processing unit communicatively coupled to the neural processing unit based on the router network and configured to coordinate the neural processing unit for performing neural network computations. Each neural processing core includes: a control register block configured to receive and store partial sum configuration information from the host processing unit; and a partial sum interface communicatively coupled to the control register block and configured to transmit a first partial sum neural packet generated by the neural processing core to a first another neural processing core of the plurality of neural processing cores and/or receive a second partial sum neural packet generated by a second another neural processing core of the plurality of neural processing cores, based on the partial sum configuration information stored in the neural processing core. Furthermore, a first set of neural processing cores of the plurality of neural processing cores are combinable based on the partial sum configuration information respectively stored therein to form a first neurosynaptic column chain. There is also provided a corresponding method of operating and a corresponding method of forming the neural network processor system.

Classes IPC  ?

• G06N 3/045 - Combinaisons de réseaux
• G06N 3/091 - Apprentissage actif

Abrégé

Devices and method for synchronized light and sound emission are disclosed. The device comprises: a first electrode layer; a second electrode layer; and a composite material layer disposed between the first electrode layer and the second electrode layer, the composite material layer having an electromechanical active matrix and an electroluminescent component; and wherein the electroluminescent component comprises a plurality of particle sets dispersed in the electromechanical active matrix, each particle set being continuous and having two ends each in contact with a respective one of the first and second electrode layers.

Classes IPC  ?

• C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
• C09K 11/56 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du soufre
• C09K 11/57 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du manganèse ou du rhénium
• C09K 11/58 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du cuivre, de l'argent ou de l'or
• H04R 3/04 - Circuits pour transducteurs pour corriger la fréquence de réponse
• H05B 33/14 - Sources lumineuses avec des éléments radiants ayant essentiellement deux dimensions caractérisées par la composition chimique ou physique ou la disposition du matériau électroluminescent
• H05B 44/00 - Circuits pour faire fonctionner des sources lumineuses électroluminescentes

Abrégé

Discloses herein is an activated metal-organic framework of formula as defined in the application, and the metal organic framework has a BET surface area of from 250 to 1,000 m2/g as obtained from a 298 K CO2 sorption isotherm. In a particular embodiment, the activated metal-organic framework is aluminium formate (Al(HCOO)3) or vanadium formate (V(HCOO)3).

Classes IPC  ?

• B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance organique
• B01D 53/04 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse avec adsorbants fixes
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
• B01J 20/34 - Régénération ou réactivation
• C07F 5/06 - Composés de l'aluminium
• C07F 15/02 - Composés du fer

Abrégé

A screen-printing ink, a method (10) of manufacturing the screen-printing ink, a 5 method (50) of producing a screen-printed electrode, and a screen-printed electrode are provided. The screen-printing ink includes graphite, an electrically conductive binder to bind the graphite, a cross-linking agent to cross-link the binder, and at least one of a conductivity modifier and a hydrophobicity modifier.

Classes IPC  ?

• C09D 11/52 - Encres conductrices de l’électricité
• C09D 7/80 - Procédés pour l'incorporation d'ingrédients
• C09D 11/037 - Encres d’imprimerie caractérisées par des particularités autres que la nature chimique du liant caractérisées par le pigment
• C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• G01N 27/30 - Composants de cellules électrolytiques Électrodes, p.ex. électrodes pour tests; Demi-cellules
• H01B 1/24 - Matériau conducteur dispersé dans un matériau organique non conducteur le matériau conducteur comportant des compositions à base de carbone-silicium, du carbone ou du silicium
• H01B 5/14 - Conducteurs ou corps conducteurs non isolés caractérisés par la forme comprenant des couches ou pellicules conductrices sur supports isolants

Abrégé

A paint thickness measuring device and a computer-implemented method for measuring paint thickness using the same are provided. The paint thickness measuring device includes a first continuous-wave (cw) laser, a second continuous-wave laser, a photomixer, one or more computer processors, and a non-transitory computer-readable memory. The photomixer includes an optical coupler configured to mix laser lights emitted by the first and second continuous-wave lasers and generate a terahertz (THz) wave, a photomixer emitter configured to emit the terahertz wave, and a photomixer receiver configured to detect the terahertz wave reflected off a painted surface. The non-transitory computer-readable memory stores computer program instructions executable by the one or more computer processors to perform operations for paint thickness measurement. The operations include: comparing the detected terahertz wave to simulation results, identifying a minimum difference between the detected terahertz wave and the simulation results, and determining a paint thickness of the painted surface from the simulation results with the minimum difference.

Classes IPC  ?

• G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur

Abrégé

A data collection apparatus (10) and a computer-implemented data collection method (50) using the same are provided. The data collection apparatus (10) includes a first linear stage (12) and a second linear stage (14). A sample carriage (16) is attached to the first linear stage (12), the first linear stage (12) being operable to move the sample carriage (16) along a first axis. A probe carriage (18) is attached to the second linear stage (14), the second linear stage (14) being operable to move the probe carriage (18) along a second axis. A third linear stage (20) is attached to the probe carriage (18). In use, the third linear stage (20) is operable to receive a detachable characterisation probe (22) and to move the characterisation probe (22) along a third axis. A camera (24) is attached to the probe carriage (18). In use, the camera (24) is configured to capture an image of one or more samples on the sample carriage (16).

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
• G06V 10/12 - Acquisition d’images - Détails des dispositions d’acquisition; Leurs détails structurels
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
• G06V 10/28 - Quantification de l’image, p.ex. seuillage par histogramme visant à discriminer entre les formes d’arrière-plan et d’avant-plan
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p.ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersections; Analyse de connectivité, p.ex. de composantes connectées
• G06V 20/70 - RECONNAISSANCE OU COMPRÉHENSION D’IMAGES OU DE VIDÉOS Éléments spécifiques à la scène Étiquetage du contenu de scène, p.ex. en tirant des représentations syntaxiques ou sémantiques

Abrégé

The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61K 51/10 - Anticorps ou immunoglobulines; Leurs fragments
• A61P 35/00 - Agents anticancéreux
• C07K 16/30 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• C07K 16/44 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

There is provided a method of characterising a macrophage in a tissue of a subject, wherein the method comprises determining an expression of one or more biomarkers in the macrophage, wherein the one or more biomarkers is selected from the group consisting of Folr2, SerpinaSi, Nid2, Slc27a6, SemaSa, Cdh13, Bcl6b, C6, Klf15, Marco, Cd209d, Tshz3, Bmpr1a, Tln2, Coro2b, Ackr2, 1110046J04Rik, Pcdhac2, Gm2253, Vsig4, Phactrt, NpM, CpneS, Angptl7, Gm26714, Auts2, Cxcl13, Sgce, 2900052N01 Rik, Cd209b, Timd4, Cd209g, Mrd (CD206), Spp1, Il22ra2, Gm24112, Gm23010, Ighv7-1, Gm23628, Gm24620, Gm23058, Arhgef37, Gad1-ps, Gm26397, Ighv2-5, Chil3, Mir1934, 1810012K08Rik, Ighv1-59, Gm14119, Gm19620 and Snord71. In one embodiment, the macrophage can be an embryo-derived macrophage and/or a long-lived tissue resident macrophage. In another embodiment, the macrophage can be a monocyte-derived macrophage. Also disclosed are methods of diagnosing a disease in a subject, methods of treating a disease, and kits for use thereof relating to a macrophage determined to express one or more of the said biomarkers.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p.ex. séquençage par hybridation [SBH]
• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour le typage de tissu ou de cellule, p.ex. sondes d’antigène leucocytaire humain [HLA]

Abrégé

The invention relates to anti-CEACAM5/6 antigen-binding molecules and humanized variants thereof that bind to CEACAM5/6 that is glycosylated at N256. It also relates to the use of said antigen-binding molecules in methods of detection and medical treatment thereof.

Classes IPC  ?

• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux
• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

Synthesis of enantiopure cis-α-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-α-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-α-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-α-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-α-irone including the use of glucose as feedstock for the biotransformation into cis-α-irone.

Classes IPC  ?

• C12P 7/26 - Cétones
• C12N 9/10 - Transférases (2.)
• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12P 41/00 - Procédés utilisant des enzymes ou des micro-organismes pour la séparation d'isomères optiques à partir d'un mélange racémique

Abrégé

An optical system and a method of forming the same. The optical system may include a light source configured to generate a light beam, the light beam being coherent or partially coherent. The optical system may also include a spatial light modulator configured to modulate a phase of the light beam. The optical system may further include an eyepiece for directing the modulated light beam to an eye of a viewer, the eyepiece arranged such that an optical distance between the spatial light modulator and a main plane of the eyepiece is greater than a focal length of the eyepiece. The spatial light modulator may include an active display area having a dimension of less than 2 mm.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

The present invention relates to processes for depolymerizing a polyester of a dicarboxylic acid and for hydrolyzing a diester of terephthalic acid in the presence of a first base and a solvent mixture into a mono-salt of a monoester of the dicarboxylic acid and further comprises the further treatment of said mono-salt product into other useful derivatives, wherein the solvent mixture comprises at least one aprotic solvent and at least one protic solvent; and wherein the aprotic solvent and protic solvent are provided in a volume ratio of from 1:10 to 100:1. In a preferred embodiment, the aprotic solvent is dichloromethane (DCM), acetonitrile (ACN), tetrahydrofuran (THF) or diethyl ether; and the protic solvent is methanol, ethanol, or allyl alcohol; and the base is potassium hydroxide (KOH).

Classes IPC  ?

• C08J 11/24 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p.ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes hydroxyle
• C07C 51/09 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides à partir de lactones ou d'esters d'acides carboxyliques
• C07C 67/03 - Préparation d'esters d'acides carboxyliques par réaction d'un groupe ester avec un groupe hydroxyle
• C07C 67/30 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester

Abrégé

Various embodiments may relate to a resonator. The resonator may include a support including a substrate portion, and a membrane portion extending from the substrate portion over a cavity. The resonator may also include a piezoelectric layer on the membrane portion. The resonator may further include an electrode on the piezoelectric layer. The substrate portion may include dopants of a first conductivity type. The membrane portion may include dopants of a second conductivity type different from the first conductivity type. A ratio of a thickness of the membrane portion to a combined thickness of the electrode and the piezoelectric layer may be above 3:1 for temperature compensation.

Classes IPC  ?

• H03H 9/13 - Moyens d'excitation, p.ex. électrodes, bobines pour réseaux se composant de matériaux piézo-électriques ou électrostrictifs
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique

Abrégé

There is provided a multimodality method and a system for printing a three-dimensional (3D) construct or part thereof, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be crosslinked through irradiation by an irradiation source; (ii) depositing one or more materials on/within the flowable precursor; and (iii) crosslinking through irradiation by the irradiation source, at least part of the flowable precursor that is in contact with the one or more materials in the flowable precursor to form the 3D construct or part thereof.

Classes IPC  ?

• B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
• B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p.ex. de buses de jet
• B29C 64/209 - Têtes; Buses
• B29C 64/264 - Agencements pour irradiation
• B29C 64/336 - Alimentation de plusieurs matériaux
• B29C 64/40 - Structures de support des objets en 3D pendant la fabrication, lesdites structures devant être sacrifiées après réalisation de la fabrication
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet

Abrégé

Various embodiments relate generally to the field of nucleic acid amplification and detection, in particular isothermal nucleic acid amplification and the detection of the amplicons using designated detection probes. Moreover, various embodiments also relate to methods for determining the presence or quantity of a target nucleic acid molecule in a sample using isothermal amplification. The detection probe is a single-stranded probe that recognises a probe binding site within target amplicons. The detection probe comprises at least one 3′end nucleotide mismatch and a quencher-fluorophore pair at the opposite ends of the probe. Following hybridization of the detection probe to the target amplicons, a DNA polymerase with 3′-5′ exonuclease activity can cleave the detection probe at the 3′ end nucleotide mismatch to release a 3′-terminal probe fragment comprising the quencher or fluorophore, thus generating signals.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p.ex. transfert d’énergie de résonance
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques

Abrégé

Provided is a method for producing at least one type of thermoplastic resin selected from polycarbonate, polyester and polyester carbonate. The method includes a step of subjecting a dihydroxy compound and diaryl carbonate and/or dicarboxylic acid ester to melt polycondensation in the presence of a transesterification catalyst selected from a compound represented by formula (1) and/or formula (2). In formula (1), R1 to R24 are each a hydrogen atom, an alkyl group having 1-10 carbon atoms or a cycloalkyl group. Some of the carbon atoms may be substituted by heteroatoms. Among R1 to R24, alkyl groups or the like substituted on the same N atom may bond to each other to form a ring. The values of a to d are each 0 or 1. X− is a monovalent anion. In formula (2), Ar1 to Ar12 are each a substituted or unsubstituted aryl group. M− is a monovalent anion.

Classes IPC  ?

• C08G 64/30 - Procédés généraux de préparation utilisant des carbonates

Abrégé

The disclosure provides anti-DENV antibodies having a cross-reactivity to ZIKV and methods of making and using the same. The anti-DENV antibodies have uses that include treating or preventing ZIKV infection.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

Multi-well plate compatible device or insert for three-dimensional (3D) cell cultures, use and kit thereof are provided. The device includes outer and inner walls. the inner wall defining a volume and is located within the outer wall, forming a cavity therebetween. It also includes a base configured to position a cell culture sample below the volume within the inner wall and one or more partitions connected to the base. connecting the inner wall to the outer wall and segmenting the cavity into a plurality of voids. Openings in surfaces forming the voids allow fluid flow from a first void. below the volume within the inner wall to a second void, the fluid flow configured to interact with the cell culture sample when flowing through a sample region within the inner wall. The sample region has a depth defined by a height of the inner wall greater than a length defined by an inner distance across the volume within the inner wall.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

Abrégé

A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.

Classes IPC  ?

• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase
• C12N 9/90 - Isomérases (5.)
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12P 5/02 - Préparation des hydrocarbures acycliques
• C12P 7/26 - Cétones
• C12P 23/00 - Préparation de composés contenant un cycle cyclohexène comportant une chaîne latérale non saturée d'au moins dix atomes de carbone liés par des doubles liaisons conjuguées, p.ex. carotènes

Abrégé

In some aspects, a method for generating encoded plaintext data in a plaintext vector space includes obtaining a plurality of vectors of plaintext elements, where each plaintext element is an element of a first finite field. The method further includes encoding the plurality of vectors of plaintext elements to a vector of field elements, where each vector of plaintext elements is encoded to a respective field element of the vector of field elements, each of the field elements is an element of a second finite field, and the second finite field is a finite extension field of the first finite field. The method additionally includes encoding the vector of field elements into an element of the plaintext vector space to produce the encoded plaintext data for homomorphic encryption and computation.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/06 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p.ex. système DES

Abrégé

A method of localizing a mobile robot 100 with respect to a target object 601 using an initial map of a reference object which is a representation of the target object is disclosed herein. The method comprises obtaining LiDAR data 503 of the target object 601 captured by a LiDAR device 203 of the mobile robot 100 as the mobile robot 100 traverses in an environment associated with the target object 601 the LiDAR data including respective point cloud representations of the target object 501 and the environment in various sampling instances; iteratively updating pose data representing estimated pose of the mobile robot 100 with respect to a known reference location in corresponding sampling instances as the mobile robot traverses the environment; extracting a subset of LiDAR data points in the point cloud representation of a previous sampling instance, the subset of LiDAR data points corresponding to features of the target object 601 in the initial map based on the estimated pose of the mobile robot 100 associated with the previous sampling instance; obtaining desired LiDAR data points in the point cloud representation in a current sampling instance, the desired LiDAR data points including current LiDAR data points which correspond to the extracted subset of LiDAR data points in the previous sampling instance; and determining a localization pose of the mobile robot 100 with respect to the target object 601 in the current sampling instance based on the desired LiDAR data points. A system for localizing a mobile robot is also disclosed herein.

Classes IPC  ?

• G05D 1/246 - utilisant des cartes d’environnement, p. ex. localisation et cartographie simultanées [SLAM]
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G05D 105/80 - pour la collecte d’informations, p. ex. recherche universitaire
• G05D 111/10 - Signaux optiques
• G05D 111/63 - du même type, p. ex. stéréovision ou flux optique
• G06T 7/579 - Récupération de la profondeur ou de la forme à partir de plusieurs images à partir du mouvement
• G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras

Abrégé

A method of detecting a raised boundary of a routeway for a mobile object 100 is disclosed herein. In a specific embodiment, the method comprises receiving LiDAR data of an environment of the mobile object captured by a LiDAR device 101, the LiDAR data comprising a plurality of beams, each beam comprising a plurality of projected points each captured according to a common pitch angle of the LiDAR device 101; identifying a plurality of break points, each break point of the plurality of break points being in a linearity 501, 1501, 2501 of consecutive projected points of at least one beam from the plurality of beams; and locating edge points of the raised boundary from the plurality of identified break points. A system for detecting a raised boundary of a routeway for a mobile object 100 is also disclosed herein.

Classes IPC  ?

• G06V 20/56 - Contexte ou environnement de l’image à l’extérieur d’un véhicule à partir de capteurs embarqués
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G06T 7/13 - Détection de bords

Abrégé

An antenna array integrated in an integrated circuit package. The antenna array may include a first receiver column. The antenna array may also include a plurality of second receiver columns. The antenna array may also include a first transmitter column and a second transmitter column arranged between the first receiver column and the plurality of second receiver columns. A spacing between the first transmitter column and the second transmitter column may be about half a spacing between neighbouring second receiver columns of the plurality of second receiver columns. A distance between the first receiver column and a second receiver column of the plurality of second receiver columns nearest to the first receiver column may be about N times the spacing between the neighbouring second receiver columns of the plurality of second receiver columns, N being a number of second receiver columns.

Classes IPC  ?

• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles
• H01Q 1/32 - Adaptation pour l'utilisation dans ou sur les véhicules routiers ou ferroviaires
• H01Q 21/08 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles les unités étant espacées le long du trajet rectiligne ou adjacent à celui-ci

Abrégé

A method of spatial modulation using an antenna array including radiating elements having power amplifiers communicatively coupled thereto. An amplitude of an output signal to be formed in space is determined by the antenna array based on an input signal. Output amplitude levels for the radiating elements are determined based on the amplitude of the output signal and a current output amplitude level of the antenna array. The first signal(s) for a first subarray of the antenna array and the second signal(s) for a second subarray of the antenna array are generated based on the input signal. The output amplitude levels are assigned to the power amplifiers of the radiating elements. The first signal(s) are sent to radiating elements of the first subarray and the second signal(s) are sent to radiating elements of the second subarray for transmission therefrom to form a combined signal in space as the output signal.

Classes IPC  ?

• H04B 7/06 - Systèmes de diversité; Systèmes à plusieurs antennes, c. à d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission
• H04B 7/0426 - Distribution de puissance

Abrégé

The present invention is directed to a method of modulating inflammation and/or related complications triggered by ZAKα kinase-activated NLRP1-driven pyroptosis; a compound or composition comprising said compound for use in the method, and use of said compounds in medicament preparation. More particularly, the inflammation is caused by a ribotoxin or UVB irradiation. Inhibition of said ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of human airway or skin inflammation and/or related complications, whereas activation of ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of cancer.

Classes IPC  ?

• A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/365 - Lactones
• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/69 - Composés du bore
• A61K 35/748 - Cyanobactéries, c. à d. bactéries bleu-vert ou algues bleu-vert, p.ex. spiruline
• A61P 35/00 - Agents anticancéreux

Abrégé

An absorber and a method of forming an absorber. The absorber may include a semiconductor absorption structure doped with dopants of a first conductivity type. The absorber may also include a semiconductor substrate doped with dopants of a second conductivity type different from the first conductivity type. The absorber may further include a dielectric layer between the semiconductor absorption structure and the semiconductor substrate. The absorber may additionally include a buried semiconductor structure included in a cavity of the dielectric layer, the buried semiconductor structure doped with dopants of the first conductivity type.

Classes IPC  ?

• G02B 5/20 - Filtres

Abrégé

The present disclosure generally relates to a method for fabricating a nitrogenous steel material (200). The method comprises preparing a material powder in a powder reservoir (120) of an additive manufacturing apparatus (100). The material powder comprises: a metal powder comprising iron; and an alloying powder comprising nitrogen. The method further comprises performing an additive manufacturing process under atmospheric pressure, the additive manufacturing process comprising: displacing layers of the material powder from the powder reservoir (120) to a build platform (130) of the additive manufacturing apparatus (100); and fusing the layers of material powder on the build platform (130) to fabricate the nitrogenous steel material (200).

Classes IPC  ?

• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
• B22F 1/12 - Poudres métalliques contenant des particules non métalliques
• B22F 3/10 - Frittage seul
• B22F 12/58 - Moyens d’alimentation en matériau, p.ex. têtes pour modifier la composition du matériau, p.ex. en mélangeant
• C22C 38/00 - Alliages ferreux, p.ex. aciers alliés
• C22C 38/04 - Alliages ferreux, p.ex. aciers alliés contenant du manganèse
• C22C 38/22 - Alliages ferreux, p.ex. aciers alliés contenant du chrome et du molybdène ou du tungstène
• C22C 38/28 - Alliages ferreux, p.ex. aciers alliés contenant du chrome et du titane ou du zirconium

Abrégé

An integrated circuit spectrometer comprises a photonic circuit comprising: an optical input port for receiving light from a light source: and a filter array of filter elements, such as microring resonators, in optical communication with the optical input port. Each microring resonator is characterized by a different series of resonance wavelengths. If alternative filter elements are used, the filter elements may have different filter peaks to each other. The integrated circuit spectrometer also comprises a plurality of detectors, each of which is associated with one of said microring resonators to detect photons from an output of the microring resonator: and at least one processor configured to reconstruct, from signals received at the detectors, an input spectrum of the light received at the optical input port. The input spectrum may be reconstructed by an artificial neural network.

Classes IPC  ?

• G01J 3/02 - Spectrométrie; Spectrophotométrie; Monochromateurs; Mesure de la couleur - Parties constitutives
• G01J 3/12 - Production du spectre; Monochromateurs
• G01J 3/28 - Etude du spectre
• G06N 3/048 - Fonctions d’activation
• G06N 3/084 - Rétropropagation, p.ex. suivant l’algorithme du gradient

Abrégé

The invention relates to antigen-binding molecules that specifically bind to MHC Class I DLA-12 antigen. In one embodiment, the antigen-binding molecule is an antibody that specifically binds to canine MHC Class I DLA-12 antigen. Chimeric molecules of the antibody conjugated to another heterologous moiety are also provided. In one embodiment, the heterologous moiety is monomethyl auristatin E (MMAE). A method of inhibiting cancer using the antibody or the chimeric molecule thereof is also provided. In another embodiment, the antibody-MMAE conjugate suppresses tumour development in a murine model of B cell lymphoma.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed is an expression vector comprising a polynucleotide encoding for a glutamine synthetase with reduced activity compared to a wild type glutamine synthetase. Also disclosed are host cells, methods for preparing stable cell line, methods of producing polypeptide of interest, and kits thereof.

Classes IPC  ?

• C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

Disclosed herein are methods and treatments for cartilage degradation, wherein the method comprises administration of a therapeutic agent which inhibits the Ga1N Ac-T activation (GALA) pathway.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p.ex. arthrites, arthroses

Abrégé

The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.

Classes IPC  ?

• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour le typage de tissu ou de cellule, p.ex. sondes d’antigène leucocytaire humain [HLA]

Abrégé

The present invention relates to an electrolyte comprising lithium difluoro(oxalate)borate (LiDFOB) and a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M, a rechargeable battery comprising the electrolyte as described herein, a cathode layer, an anode layer and a separator, and a method of preparing the electrolyte as described herein, comprising the step of dissolving LiDFOB in a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M.

Classes IPC  ?

• H01M 10/0568 - Matériaux liquides caracterisés par les solutés
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
• H01M 10/0569 - Matériaux liquides caracterisés par les solvants

Abrégé

The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene. The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.

Classes IPC  ?

• C07F 9/6568 - Composés hétérocycliques, p.ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore comme uniques hétéro-atomes du cycle
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique

Abrégé

There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61F 13/08 - Bandages ou pansements; Garnitures absorbantes spécialement conçus pour les pieds ou les jambes; Coussinets pour cors; Anneaux pour cors pour comprimer les anévrismes

Abrégé

In some aspects, a set of input elements is obtained, at a rectified linear unit-activated neuron of a neural network based, on input data at the neuron. A first group and a second group of input elements are generated based on the set of input elements. The first group and the second group of input elements are associated with first weight elements and second weight elements, respectively. A first value is generated based on the first group of input elements and the first weight elements. A second value is generated based on the second group of input elements and the second weight elements. A third value and a fourth value are respectively generated based on a first operation and a second operation on the first value and the second value. An output of the neuron is generated based on the third value and the fourth value.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

There is provided a method of privacy-preserving logistic regression training based on homomorphically encrypted ciphertexts. The method includes: obtaining a first packed ciphertext comprising at least a portion of a first training data sample packed into a first vector of slots thereof for training a privacy-preserving logistic regression model; obtaining a second packed ciphertext comprising a plurality of weights of the privacy-preserving logistic regression model packed into a first vector of slots thereof; determining at least a first output probability of the privacy-preserving logistic regression model based on the first packed ciphertext and the second packed ciphertext; and updating the plurality of weights based on the first output probability. There is also provided a corresponding system for privacy-preserving logistic regression training based on homomorphically encrypted data.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.

Classes IPC  ?

• A01N 59/16 - Métaux lourds; Leurs composés
• C09D 5/14 - Peintures contenant des biocides, p.ex. fongicides, insecticides ou pesticides
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• A01N 25/12 - Poudres ou granulés
• A61K 33/06 - Aluminium, calcium ou magnésium; Leurs composés
• A61K 33/32 - Manganèse; Ses composés
• A61K 33/30 - Zinc; Ses composés
• A61K 33/26 - Fer; Ses composés
• A61K 9/50 - Microcapsules
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges

Abrégé

Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 35/00 - Agents anticancéreux
• C07K 16/46 - Immunoglobulines hybrides

Abrégé

We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

Classes IPC  ?

• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules: amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.

Classes IPC  ?

• C08F 222/10 - Esters
• C08F 222/26 - Esters d'alcools non saturés
• C08F 2/06 - Solvant organique

Abrégé

A titanium-tantalum alloy having a titanium wt % ranging from 10% to 70% and wherein the titanium has a body centered cubic structure. A method of forming a titanium-tantalum alloy, the method comprising the steps of: (a) slicing a 3D CAD model of a part to be formed into a plurality of 2D image layers; (b) preparing a homogenous powder mixture of titanium powder and tantalum powder; (c) dispensing a layer of the powder mixture onto a processing bed; (d) performing powder bed fusion of the layer of the powder mixture according to one of the 2D image layers in one of: a vacuum environment and an inert gas environment; and performing steps (c) and (d) for each of the plurality of 2D image layers in succession.

Classes IPC  ?

• C22C 14/00 - Alliages à base de titane
• B33Y 10/00 - Procédés de fabrication additive
• C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B22F 1/05 - Poudres métalliques caractérisées par la dimension ou la surface spécifique des particules
• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]

Abrégé

There is provided a device for processing homomorphically encrypted data. The device includes: inter-line butterfly array blocks, each inter-line butterfly array block including inter-line modulus butterfly units, each inter-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same row of a matrix of input data points; intra-line butterfly array blocks, each intra-line butterfly array block including intra-line modulus butterfly units, each intra-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same column of the matrix of input data points; and a clock counter communicatively coupled to each inter-line butterfly array block and each intra-line butterfly array block, and configured to output a counter signal for controlling each inter-line butterfly array block and each intra-line butterfly array block to operate with single cycle initiation interval. The matrix of input data points includes columns of input data points, whereby parallel input data points derived from the homomorphically encrypted data are arranged into the columns of input data points. Furthermore, the inter-line butterfly array blocks and the intra-line butterfly array blocks are arranged in series to form a pipeline for processing the matrix of input data points.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• G06F 9/38 - Exécution simultanée d'instructions
• G06F 7/72 - Méthodes ou dispositions pour effectuer des calculs en utilisant une représentation numérique non codée, c. à d. une représentation de nombres sans base; Dispositifs de calcul utilisant une combinaison de représentations de nombres codées et non codées utilisant l'arithmétique des résidus

Abrégé

Various embodiments may relate to a piezoelectric device. The piezoelectric device may include a substrate, and a layered stacked arrangement anchored to the substrate. The layered stacked arrangement may include a piezoelectric layer. The stacked arrangement may also include a first electrode on a first side of the piezoelectric layer. The stacked arrangement may further include a second electrode on a second side of the piezoelectric layer opposite the first side. The piezoelectric layer may include a first region including one or more dipole domains of a first type, and one or more dipole domains of a second type. The first electrode may be at least partially in contact with the first region and at least partially in contact with the second region.

Classes IPC  ?

• H10N 30/20 - Dispositifs piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique, p.ex. fonctionnant comme actionneurs ou comme vibrateurs
• H10N 30/853 - Compositions céramiques
• H10N 30/076 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par dépôt de couches piézo-électriques ou électrostrictives, p.ex. par impression par aérosol ou par sérigraphie par dépôt en phase vapeur

Abrégé

The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

There is provided a device for vascularising a cell aggregate, the device comprising: a matrix region configured to contain a gel-like matrix and cells that form a vasculature network within th ematrix region. The matrix region having at least one opening for positioning the cell aggregate therein based on a desired three-dimensional spatial location; and one or more fluidic regions configured to contain a supporting fluid that is capable of supporting vascularisation of the cell aggregate, the one or more fluidic regions being in fluid communication with the matrix region, wherein a flow passage from the one or more fluidic regions to a gel-like matrix disposed in the matrix region is configured to allow three-dimensional vascularisation around the cell aggregate and perfusion of the vasculature once formed. There is also provided a chip comprising a plurality of the device as disclosed herein and a method for vascularising a cell aggregate.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains

Abrégé

Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.

Classes IPC  ?

• H10N 30/067 - Formation d’électrodes à une seule couche de parties piézo-électriques ou électrostrictives multicouches
• H10N 30/87 - Dispositifs piézo-électriques ou électrostrictifs - Détails de structure Électrodes ou interconnexions, p.ex. connexions électriques ou bornes
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique
• H10N 30/07 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs

Abrégé

The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed is an expression system for an antigen binding molecule and the uses thereof.

Classes IPC  ?

• C07K 16/46 - Immunoglobulines hybrides
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

This document describes a spatial light modulator that comprises a pixel array having a plurality of pixels whereby each pixel in this array is communicatively coupled to a digital pixel circuit which are in turn all coupled to a bit-plane control circuit. The bit-plane control circuit is configured to generate, using a Pulse Code Modulation (PCM) algorithm, bit-plane signals that are used to control the sample and hold functions performed by each of the digital pixel circuits so that the pixel array may carry out its scanning function accurately and in a power efficient manner.

Classes IPC  ?

• G11C 11/418 - Circuits d'adressage
• G02F 1/133 - Dispositions relatives à la structure; Excitation de cellules à cristaux liquides; Dispositions relatives aux circuits
• G02F 1/1343 - Electrodes
• G02F 1/1368 - Cellules à adressage par une matrice active dans lesquelles l'élément de commutation est un dispositif à trois électrodes
• G09G 3/36 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante utilisant des cristaux liquides

Abrégé

There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.

Classes IPC  ?

• C08G 81/02 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p.ex. polymères séquencés au moins un des polymères étant obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carbone
• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle

Abrégé

A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.

Classes IPC  ?

• B25J 15/12 - Têtes de préhension avec des éléments en forme de doigts avec des éléments en forme de doigts flexibles
• B25J 15/10 - Têtes de préhension avec des éléments en forme de doigts avec au moins trois éléments en forme de doigts
• B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion

Abrégé

There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule. There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.

Classes IPC  ?

• C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p.ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle

Abrégé

The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

Classes IPC  ?

• C07D 491/08 - Systèmes pontés
• C07D 215/233 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 4
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 451/06 - Atomes d'oxygène
• C07D 451/14 - Composés hétérocycliques contenant des systèmes cycliques aza-8 bicyclo [3.2.1] octane, aza-9 bicyclo [3.3.1] nonane ou oxa-3 aza-9 tricyclo [3.3.1.02,4] nonane, p.ex. alcaloïdes du tropane ou du granatane, scopolamine; Leurs acétals cycliques  contenant des systèmes cycliques aza-9 bicyclo [3.3.1] nonane, p.ex. granatane, aza-2 adamantane; Leurs acétals cycliques

Abrégé

Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnie; Test des temps de réaction
• A61B 5/378 - Stimuli visuels

Abrégé

The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.

Classes IPC  ?

• C07K 14/335 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Lactobacillus (G)
• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase

Abrégé

A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.

Classes IPC  ?

• C09C 3/06 - Traitement par des composés inorganiques
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• C09D 7/40 - Adjuvants
• C09D 5/33 - Peintures réfléchissantes
• C09C 1/28 - Composés du silicium

Abrégé

Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.

Classes IPC  ?

• G01N 21/3518 - Dispositifs utilisant des techniques de corrélation à filtres de gaz; Dispositifs utilisant des techniques de modulation de la pression des gaz
• G01N 21/05 - Cuvettes à circulation de fluides

Abrégé

The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/522 - Purines, p.ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p.ex. hypoxanthine, guanine, acyclovir

Abrégé

An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.

Classes IPC  ?

• B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p.ex. avec des séparateurs électrostatiques; Ensembles ou systèmes de plusieurs centrifugeurs
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• B01D 21/26 - Séparation du sédiment avec emploi de la force centrifuge
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/26 - Inoculateur ou échantillonneur
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01D 43/00 - Séparation de particules de liquides, ou de liquides de solides, autrement que par sédimentation ou filtration

Abrégé

The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.

Classes IPC  ?

• A23D 9/04 - Traitement
• A23D 9/007 - Autres huiles ou graisses comestibles, p.ex. huiles pour cuisson caractérisées par des ingrédients autres que des triglycérides d'acides gras
• A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles, contenant une phase aqueuse, p.ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras

Abrégé

There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.

Classes IPC  ?

• G06N 3/088 - Apprentissage non supervisé, p.ex. apprentissage compétitif
• G06N 3/049 - Réseaux neuronaux temporels, p.ex. éléments à retard, neurones oscillants ou entrées impulsionnelles

Abrégé

The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis. The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.

Classes IPC  ?

• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose

Abrégé

A closure for a sample tube comprises a reaction vessel. The reaction vessel comprises: at least one microfluidic mixing channel having an inlet and an outlet; at least one reaction chamber in fluid communication with the inlet and the outlet; an inlet chamber proximate the inlet of the at least one microfluidic mixing channel for introducing a portion of a sample solution from the sample tube into the at least one reaction chamber under hydrostatic pressure; and a diffusion-control feature for limiting egress of fluid from the outlet such that the portion of the sample solution introduced to the at least one reaction chamber is partitioned from the rest of the sample solution.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

A method of producing a silicalite membrane, which includes heating an aqueous solution that includes a dopant precursor and structure-directing template agents to form silicalite seeds incorporated with a dopant, depositing a buffer layer on a ceramic substrate prior to depositing the silicalite seeds on the buffer layer, contacting the ceramic substrate with a solution including the silicalite seeds to form a silicalite layer from the silicalite seeds on the ceramic substrate, and removing the structure-directing template agents to form the silicalite membrane, where the silicalite layer includes silicalite crystals incorporated with a dopant and each of the silicalite crystals has a hollow structure which forms the pores of the silicalite layer. The silicalite membrane includes a ceramic substrate having a buffer layer formed thereon, and a silicalite layer formed on the buffer layer, where the silicalite layer includes silicalite crystals incorporated with a dopant.

Classes IPC  ?

• B01D 71/02 - Matériaux inorganiques
• B01D 69/10 - Membranes sur support; Supports pour membranes
• B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
• B01D 69/04 - Membranes tubulaires

Abrégé

Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• C12N 5/0735 - Cellules souches embryonnaires; Cellules germinales embryonnaires
• C12N 5/074 - Cellules souches adultes
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

Classes IPC  ?

• C08L 79/02 - Polyamines

Abrégé

An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

Classes IPC  ?

• G01N 21/3563 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solides; Préparation des échantillons à cet effet
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
• G01N 21/359 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche

Abrégé

Various embodiments may relate to an electro-optic modulator. The electro-optic modulator may include a waveguide configured to carry optical light along a longitudinal length of the waveguide. The electro-optic modulator may also include a first electrically conductive sub-wavelength grating on a first side of the waveguide, the first electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may further include a second electrically conductive sub-wavelength grating on a second side of the waveguide opposite the first side, the second electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may be configured to modulate the optical light upon application of a potential difference between the first electrically conductive sub-wavelength grating and the second electrically conductive sub-wavelength grating based on Pockels effect.

Classes IPC  ?

• G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
• G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence

Abrégé

The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
• B29C 33/42 - Moules ou noyaux; Leurs détails ou accessoires caractérisés par la forme de la surface de moulage, p.ex. par des nervures ou des rainures
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

The present invention is in the field of molecular diagnostics and is directed to the detection of target nucleic acids in a sample using a modified CRISPR-Dx system, typically with prior amplification of the target. The modified CRISPR-Dx system comprising an engineered E174R/S542R/K548R variant of AsCas12a, wherein when get activated indiscriminately cleaves at least one detection reagent to generate signal. In one embodiment, the target nucleic acid is SARS-CoV-2 RNA.

Classes IPC  ?

• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.

Classes IPC  ?

• G06T 7/10 - Découpage; Détection de bords
• G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
• G06T 7/64 - Analyse des attributs géométriques de la convexité ou de la concavité
• G06T 7/66 - Analyse des attributs géométriques des moments d'image ou du centre de gravité
• G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p.ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]; Caractéristiques régionales saillantes
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06T 7/00 - Analyse d'image

Abrégé

There is provided a composition comprising a slurry of capsules, the capsules having shells comprising silica and said shells encapsulating phase change materials (PCM); and a cementitious binder. There is also provided a method for preparing said composition.

Classes IPC  ?

• C09K 5/02 - Substances qui subissent un changement d'état physique lors de leur utilisation
• C04B 22/06 - Oxydes; Hydroxydes
• C04B 24/04 - Acides carboxyliques; Leurs sels, anhydrides ou esters
• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p.ex. séchage, pulvérisation
• C04B 24/38 - Polysaccharides ou leurs dérivés

Abrégé

A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).

Classes IPC  ?

• G10K 11/165 - Sélection de matériaux de particules dans une matrice
• C09D 7/61 - Adjuvants non macromoléculaires inorganiques
• C09D 7/40 - Adjuvants
• C09D 5/24 - Peintures électriquement conductrices
• C09D 163/00 - Compositions de revêtement à base de résines époxy; Compositions de revêtement à base de dérivés des résines époxy
• C09D 137/00 - Compositions de revêtement à base d'homopolymères ou de copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un hétéroc; Compositions de revêtement à base de dérivés de tels polymères
• C09D 123/08 - Copolymères de l'éthylène
• C09D 113/00 - Compositions de revêtement à base de caoutchoucs contenant des groupes carboxyle

Abrégé

There is provided a polymer or derivative thereof comprising a plurality of active amine groups in the backbone, wherein the polymer is a reaction product of a reaction between one or more bis-carbonates and one or more amine compounds having at least two terminal amino groups. Also provided are use of the polymer or derivative thereof and a method of preparing the polymer or derivative thereof.

Classes IPC  ?

• C08G 71/04 - Polyuréthanes
• C11D 11/00 - Méthodes particulières pour la préparation de compositions contenant des mélanges de détergents
• C11D 3/00 - Autres composés entrant dans les compositions détergentes couvertes par le groupe
• C11D 3/37 - Polymères
• C10M 149/14 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone faisant intervenir une réaction de condensation
• A01N 47/12 - Dérivés de l'acide carbamique, c. à d. contenant le groupe —O—CO—N; Leurs thio-analogues contenant un groupe —O—CO—N, ou un de ses thio-analogues, non directement lié à un cycle et l'atome d'azote n'étant pas un chaînon d'un hétérocycle
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• B01D 53/62 - Oxydes de carbone
• B01D 53/78 - Procédés en phase liquide avec un contact gaz-liquide
• B01D 53/14 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption

Abrégé

This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

A chemical sensor that includes a first semiconductor substrate. The chemical sensor may also include a second semiconductor substrate. The chemical sensor may further include one or more metal layers between the first semiconductor substrate and the second semiconductor substrate such that the first and second semiconductor substrates and the one or more metal layers form a cell including a cavity, the cavity having a depth of any value equal to or less than 100 μm. The chemical sensor may also include an optical source. The chemical sensor may additionally include an optical detector such that light emitted by the optical source passes through the cell to the optical detector. The first and second semiconductor substrates and the one or more metal layers may also define at least one inlet for fluid to flow into the cavity and at least one outlet for fluid to flow out of the cavity.

Classes IPC  ?

• H01L 25/16 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant de types couverts par plusieurs des groupes principaux , ou dans une seule sous-classe de , , p.ex. circuit hybrides
• G01N 21/61 - Analyseurs de gaz non dispersifs
• H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide

Abrégé

The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.

Classes IPC  ?

• A61K 31/4545 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pipampérone, anabasine
• A61L 27/24 - Collagène
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Abrégé

A method of producing a silica-based superhydrophilic film. A coating formulation is provided, where the coating formulation includes an alkali metal silicate having a substantial portion of water removed therefrom, where the alkali metal silicate has a formula of M2O·nSiO2, and where M represents an alkali metal and n is a positive real number greater than zero. Furthermore, the coating formulation and an alcohol including a curing agent are mixed, where the curing agent includes an acid or an alkaline earth metal halide. Additionally, the coating formulation is dried to form the silica-based superhydrophilic film. Furthermore, a silica-based superhydrophilic film is produced according to such a method, where the silica-based superhydrophilic film includes an amine stabilizer.

Classes IPC  ?

• C09D 183/02 - Polysilicates
• C08G 77/02 - Polysilicates
• C09D 1/04 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de substances inorganiques silicates de métaux alcalins avec des adjuvants organiques

Abrégé

A polymer having a backbone and a side unit of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide bonded thereto, where the backbone of the polymer includes at least one heterocyclic moiety. There is also provided a process for producing the polymer as defined herein as well as a flame retardant polyolefin formulation including the polymer as defined herein and a moulded article including the flame retardant polyolefin formulation as defined herein.

Classes IPC  ?

• C08G 73/06 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale de la macromolécule; Polyhydrazides; Polyamide-acides ou précurseurs similaires de polyimides
• C08K 3/32 - Composés contenant du phosphore
• C08L 23/12 - Polypropylène

Abrégé

This invention relates to a portable magnetic particle imaging (MPI) device. The portable MPI device comprises a handheld probe and a processing unit. The handheld probe comprises a main housing a first sensor coil, a second sensor coil, a transmitter coil arranged between the first and second sensor coils, and an excitation priming frame housing magnetic component and the processing unit comprises a transmitter communicatively connected to the transmitter coil and the excitation priming frame, a receiver communicatively connected to the first and second sensor coils.

Classes IPC  ?

• G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
• G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques
• A61B 5/0515 - Imagerie par particules magnétiques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

There is provided a hydrogel binder and a method of synthesizing the same. There is also provided a free-standing electrode comprising the hydrogel binder and a method of preparing the free-standing electrode comprising the hydrogel binder. There is further provided a battery comprising the free-standing electrode as defined herein.

Classes IPC  ?

• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p.ex. liants, charges
• H01M 4/131 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif Électrodes pour accumulateurs à électrolyte non aqueux, p.ex. pour accumulateurs au lithium; Leurs procédés de fabrication Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p.ex. LiCoOx
• C08L 5/04 - Acide alginique; Ses dérivés
• C08L 79/02 - Polyamines

Abrégé

Disclosed herein is a clear cell renal cell carcinoma (ccRCC) biomarker set. Also disclosed herein is a detection system using the biomarker set disclosed herein, methods of determining whether a subject has or shows recurrence of clear cell renal cell carcinoma, method of determining whether a renal mass sample is benign or malignant, method of detecting response of a subject to systemic treatment, and a kit for carrying out the same.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

There is provided a coral-like composite material comprising highly dispersed conductive metal nitride, metal carbide or metal carbonitride nanoparticles on mesoporous carbon nanosheets, and a method of preparing the same. There is also provided a coating material for a modified separator of a lithium-sulfur battery comprising the coral-like composite material as described herein, a conducting carbon material and a binder, and a method of preparing the same.

Classes IPC  ?

• C01B 32/158 - Nanotubes de carbone
• C01B 32/914 - Carbures d’un seul élément
• H01M 50/431 - Matériau inorganique
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/058 - Structure ou fabrication
• C01B 21/06 - Composés binaires de l'azote avec les métaux, le silicium ou le bore
• C01B 21/082 - Composés contenant de l'azote et des non-métaux

Abrégé

There is provided a method of forming a structure that is in contact with an object, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be in contact with the object; and (ii) crosslinking at least part of the flowable precursor that is in contact with the object to form a structure that is in contact with the object, wherein a top surface of the part of the flowable precursor that is to be crosslinked, is in interface with a fluid medium. Also provided is a system for performing the method.

Classes IPC  ?

• B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/06 - Titane ou alliages de titane
• B29C 64/245 - Plates-formes ou substrats
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

The present disclosure generally relates to a method of fabricating a graded metallic structure by additive manufacturing and the graded metallic structure thereof. The method comprises preparing a material powder in a supply container, the material powder is partitioned into a plurality of longitudinal volumes and comprises different metallic powders, performing an additive manufacturing process comprising supplying layers of the material powder from the supply container, displacing the layers of material powder to a fabrication platform and fusing the layers of material powder on the fabrication platform to form the graded metallic structure, wherein at least one longitudinal volume has a varying transverse cross-sectional area and at least one longitudinal volume has a varying longitudinal cross-sectional area, such that the fused metallic powders in the graded metallic structure are graded along the longitudinal and the transverse. This method is proven to be effective to make graded metal parts with composition gradients in two dimensions.

Classes IPC  ?

• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
• B22F 10/38 - Commande ou régulation des opérations pour obtenir des caractéristiques spécifiques du produit, p.ex. le lissage de la surface, la densité, la porosité ou des structures creuses
• B22F 10/37 - Commande ou régulation des opérations des caractéristiques du lit de poudre, p.ex. de la densité
• B22F 1/00 - Poudres métalliques; Traitement des poudres métalliques, p.ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
• B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p.ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation
• B22F 9/04 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau solide, p.ex. par broyage, meulage ou écrasement à la meule