Abrégé

An optical system and a method of forming the same. The optical system may include a light source configured to generate a light beam, the light beam being coherent or partially coherent. The optical system may also include a spatial light modulator configured to modulate a phase of the light beam. The optical system may further include an eyepiece for directing the modulated light beam to an eye of a viewer, the eyepiece arranged such that an optical distance between the spatial light modulator and a main plane of the eyepiece is greater than a focal length of the eyepiece. The spatial light modulator may include an active display area having a dimension of less than 2 mm.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

The invention relates to antigen-binding molecules that specifically bind to MHC Class I DLA-12 antigen. In one embodiment, the antigen-binding molecule is an antibody that specifically binds to canine MHC Class I DLA-12 antigen. Chimeric molecules of the antibody conjugated to another heterologous moiety are also provided. In one embodiment, the heterologous moiety is monomethyl auristatin E (MMAE). A method of inhibiting cancer using the antibody or the chimeric molecule thereof is also provided. In another embodiment, the antibody-MMAE conjugate suppresses tumour development in a murine model of B cell lymphoma.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to methods of treating diseases or conditions associated with abnormal levels of lamin B1 protein. Disclosed herein are methods of treating pathologies of lamin B1 accumulation, such as Adult-onset Autosomal Dominant Leukodystrophy (ADLD), using farnesyltransferase inhibitors (FTIs), such as FTI-277, lonafarnib or Tipifarnib.

Classes IPC  ?

• A61K 31/4745 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. phénanthrolines
• A61K 31/4545 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pipampérone, anabasine
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

There is provided a method of preparing a meat analogue. In one embodiment, the method comprises the steps of : (a) blending a mixture comprising wheat gluten and a protein source at a weight ratio in the range of 50:50 to 70:30; (b) heating the mixture of the blending step (a) in the presence of water at a temperature in the range of 100 °C to 140 °C to form a dough; and (c) cutting the dough of the heating step (b) to form the meat analogue. There is also provided a meat analogue prepared by the method.

Classes IPC  ?

• A23J 3/18 - Protéines végétales à partir de blé

Abrégé

Various embodiments may relate to a resonator. The resonator may include a support including a substrate portion, and a membrane portion extending from the substrate portion over a cavity. The resonator may also include a piezoelectric layer on the membrane portion. The resonator may further include an electrode on the piezoelectric layer. The substrate portion may include dopants of a first conductivity type. The membrane portion may include dopants of a second conductivity type different from the first conductivity type. A ratio of a thickness of the membrane portion to a combined thickness of the electrode and the piezoelectric layer may be above 3:1 for temperature compensation.

Classes IPC  ?

• H03H 9/13 - Moyens d'excitation, p.ex. électrodes, bobines pour réseaux se composant de matériaux piézo-électriques ou électrostrictifs
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique

Abrégé

Disclosed is an expression vector comprising a polynucleotide encoding for a glutamine synthetase with reduced activity compared to a wild type glutamine synthetase. Also disclosed are host cells, methods for preparing stable cell line, methods of producing polypeptide of interest, and kits thereof.

Classes IPC  ?

• C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

The invention relates to a method of separating protein fractions from a protein sample comprising the steps of dispersing the protein sample in a deep eutectic solvent to form a dispersion, treating the dispersion with elevated temperature to form a first protein fraction and a supernatant, and followed by treating the supernatant with elevated pressure or precipitating via pH adjustment to form a second protein fraction. The method may also be carried out by the steps of treating the dispersion at an elevated pressure to form the second protein fraction and a supernatant, and followed by treating the supernatant at an elevated temperature or precipitating via pH adjustment to form the first protein fraction. The invention further relates to protein fractions obtained from the method.

Classes IPC  ?

• C07K 1/14 - Extraction; Séparation; Purification
• C07K 1/02 - Procédés généraux de préparation de peptides en solution

Abrégé

There is provided a method of obtaining at least one protein fraction from a protein sample. There is also provided a protein fraction obtained from the method as provided herein.

Classes IPC  ?

• A23J 3/14 - Protéines végétales
• A23J 1/14 - Préparation des compositions à base de protéines pour l'alimentation; Ouverture des œufs par grandes quantités et séparation du jaune du blanc à partir des tourteaux ou des graines oléagineuses
• A23L 33/185 - Protéines d’origine végétale

Abrégé

Disclosed herein are methods and treatments for cartilage degradation, wherein the method comprises administration of a therapeutic agent which inhibits the Ga1N Ac-T activation (GALA) pathway.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p.ex. arthrites, arthroses

Abrégé

A method and apparatus for penetrating a cell with a particle are described. The method includes providing a layer of cells at or proximal to a bottom end of a vessel; adding a plurality of particles to the vessel; and applying a force to move the plurality of particles towards the bottom end of the vessel to cause at least some of the plurality of particles to penetrate at least some of the cells. The apparatus includes a vessel having a bottom end for containing a layer of cells at the bottom end; and a force exerting component configured to apply a force to move a plurality of magnetic particles within the vessel towards the bottom end of the vessel to penetrate at least some of the cells with at least some of the plurality of magnetic particles.

Classes IPC  ?

• A61K 49/06 - Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM)
• A61B 5/0515 - Imagerie par particules magnétiques
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The present disclosure relates to methods of generating induced pluripotent stem cell (iPSC)-derived Kupffer cells (iKCs), where the method comprises contacting iPSC-derived macrophages with iPSC-derived hepatocytes (iHeps), kits for generating iKCs, iKCs derived by the methods as described herein, combined cell populations comprising iKCs and iHeps. Methods of detecting immune-mediated responses to an agent using the iKCs, methods of treating a disease using the iKCs or the combined cell population comprising iKCs and iHeps are also described herein.

Classes IPC  ?

• C12N 5/0786 - Monocytes; Macrophages
• A61K 35/14 - Sang; Sang artificiel
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p.ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.

Classes IPC  ?

• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour le typage de tissu ou de cellule, p.ex. sondes d’antigène leucocytaire humain [HLA]

Abrégé

The present invention relates, in general terms, to cancer biomarkers. Disclosed herein are methods of identifying cancers that are suitable for NF-κB inhibition therapy, and methods of selecting subjects for the same, comprising detecting an indicator that is indicative of a level or activity of Protein polybromo-1 (PB1) in a sample obtained from the subject, wherein the cancer is identified as being likely to be responsive to the inhibitor of NF-κB signalling when the level or activity of PB1 indicated by the indicator corresponds to an absence or decreased level or activity of PB1 in the sample as compared to a control.

Classes IPC  ?

• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• A61K 31/69 - Composés du bore
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to an electrolyte comprising lithium difluoro(oxalate)borate (LiDFOB) and a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M, a rechargeable battery comprising the electrolyte as described herein, a cathode layer, an anode layer and a separator, and a method of preparing the electrolyte as described herein, comprising the step of dissolving LiDFOB in a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M.

Classes IPC  ?

• H01M 10/0568 - Matériaux liquides caracterisés par les solutés
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
• H01M 10/0569 - Matériaux liquides caracterisés par les solvants

Abrégé

Disclosed herein are a method of identifying therapeutically potent mesenchymal stem cells (MSCs) and a method of distinguishing MSCs from human fibroblasts, comprising detecting HOXA9 expression in the cell. Also disclosed is a method of treating diseases in a subject in need of MSCs, comprising modifying MSCs to overexpress HOXA9 and administering the modified MSCs to the subject in need.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12N 5/0775 - Cellules souches mésenchymateuses; Cellules souches dérivées du tissu adipeux
• A61K 35/28 - Moelle osseuse; Cellules souches hématopoïétiques; Cellules souches mésenchymateuses de toutes origines, p.ex. cellules souches dérivées de tissu adipeux
• A61P 19/00 - Médicaments pour le traitement des troubles du squelette

Abrégé

The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene. The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.

Classes IPC  ?

• C07F 9/6568 - Composés hétérocycliques, p.ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de phosphore, avec ou sans atomes d'azote, d'oxygène, de soufre, de sélénium ou de tellure, comme hétéro-atomes du cycle comportant des atomes de phosphore comme uniques hétéro-atomes du cycle
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique

Abrégé

In some aspects, a hand-held probe for a Raman spectroscopy system is provided. The hand-held probe includes an excitation module, configured to emit a light beam along a light path; a beam splitter, oriented to reflect the light beam along the observation axis; an objective module, configured to receive the reflected light beam and transmit the reflected light beam to an object so as to generate a scattered light beam by the object, and configured to receive and transmit the scattered light beam to the beam splitter; a focusing mirror, configured to focus the refracted light beam from the beam splitter to a focus so as to generate a focused light beam; and an emission module, disposed at the focus and configured to receive the focused light beam, wherein the emission module is disposed at a same side as the excitation module with respect to the observation axis.

Classes IPC  ?

• G01J 3/02 - Spectrométrie; Spectrophotométrie; Monochromateurs; Mesure de la couleur - Parties constitutives
• G01J 3/44 - Spectrométrie Raman; Spectrométrie par diffusion
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G01N 21/65 - Diffusion de Raman

Abrégé

The present invention relates to cell biology. In particular, the present invention teaches methods of contacting the cells with a LING complex inhibitor to inhibit durotaxis and, in consequence, reduce fibrosis and metastasis. Methods of treating wound healing are also disclosed herein.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 11/16 - Analeptiques respiratoires centraux
• A61P 3/04 - Anorexigènes; Médicaments de l'obésité
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p.ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

There is provided a method detecting the presence of a nucleic acid in a sample, the method comprises performing an amplification reaction on the sample in the presence of a proofreading polymerase and a primer with a 2'-sugar modification. Also provided is a method of identifying a disease in subject and a kit for detecting a nucleic acid in a sample.

Classes IPC  ?

• C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle

Abrégé

There are provided a method of treating a solid contact and a solid contact obtained from the method. There are also provided a method of preparing an ion-selective electrode and an ion-selective electrode prepared by the method. There is further provided a method of sensing an ion in a sample.

Classes IPC  ?

• G01N 27/333 - Electrodes ou membranes sélectives à l'égard des ions
• H01B 1/12 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisés; Emploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques substances organiques
• H01G 11/48 - Polymères conducteurs
• C08G 61/12 - Composés macromoléculaires contenant d'autres atomes que le carbone dans la chaîne principale de la macromolécule

Abrégé

There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61F 13/08 - Bandages ou pansements; Garnitures absorbantes spécialement conçus pour les pieds ou les jambes; Coussinets pour cors; Anneaux pour cors pour comprimer les anévrismes

Abrégé

The present disclosure concerns a method of biosynthesizing an antimicrobial compound of Formula (I), the method comprising culturing a microbial cell that is engineered to overexpress fatty-acyl CoA synthase (FAS) or RedD; and isolating the antimicrobial compound of Formula (I) that is produced by the microbial cell; wherein the biosynthesis of antimicrobial compound of Formula (I) is upregulated by at least about 2-fold compared to a tetramic acid analogue derived from a wild type microbial cell. The present disclosure also concerns a compound of Formula (I) and their use in treating a microbial disease or condition.

Classes IPC  ?

• A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
• A61P 31/04 - Agents antibactériens
• C12N 15/76 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p.ex. Lactobacillus, Micromonospora pour Streptomyces

Abrégé

A leaching device (10) is provided. The leaching device (10) includes a motor (12) and a receptacle (14) rotatably coupled to the motor (12), the receptacle (14) being configured to receive a sample container. A plurality of ultrasonic transducers (16) is 5 attached to the receptacle (14). An ultrasonic generator (18) is coupled to the ultrasonic transducers (16). When in use, the ultrasonic generator (18) is configured to energise the ultrasonic transducers (16) to radiate ultrasonic waves to sonicate a sample in the sample container received in the receptacle (14). A controller (20) is configured to control operation of the motor (12) and the ultrasonic generator (18), the motor (12) and the 0 ultrasonic generator (18) being simultaneously operable.

Classes IPC  ?

• B01F 29/00 - Mélangeurs à récipients rotatifs
• B01F 31/80 - Mélange au moyen de vibrations à haute fréquence supérieures à 1 kHz, p.ex. de vibrations ultrasoniques
• G01N 33/24 - Matériaux de la terre
• G01N 1/28 - Préparation d'échantillons pour l'analyse

Abrégé

In some aspects, a set of input elements is obtained, at a rectified linear unit-activated neuron of a neural network based, on input data at the neuron. A first group and a second group of input elements are generated based on the set of input elements. The first group and the second group of input elements are associated with first weight elements and second weight elements, respectively. A first value is generated based on the first group of input elements and the first weight elements. A second value is generated based on the second group of input elements and the second weight elements. A third value and a fourth value are respectively generated based on a first operation and a second operation on the first value and the second value. An output of the neuron is generated based on the third value and the fourth value.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

There is provided an antigen binding protein that specifically binds to yellow fever virus wherein the antigen binding protein comprises (1) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 1-3 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 7-9; or (2) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 4-6 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 10-12. Also disclosed are polynucleotides, vectors, and host cells expressing the antigen binding protein thereof. Also disclosed are methods of detecting, kits, and methods of preventing or treating a yellow fever virus infection in a subject in need thereof.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

There is provided a method of privacy-preserving logistic regression training based on homomorphically encrypted ciphertexts. The method includes: obtaining a first packed ciphertext comprising at least a portion of a first training data sample packed into a first vector of slots thereof for training a privacy-preserving logistic regression model; obtaining a second packed ciphertext comprising a plurality of weights of the privacy-preserving logistic regression model packed into a first vector of slots thereof; determining at least a first output probability of the privacy-preserving logistic regression model based on the first packed ciphertext and the second packed ciphertext; and updating the plurality of weights based on the first output probability. There is also provided a corresponding system for privacy-preserving logistic regression training based on homomorphically encrypted data.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.

Classes IPC  ?

• A01N 59/16 - Métaux lourds; Leurs composés
• C09D 5/14 - Peintures contenant des biocides, p.ex. fongicides, insecticides ou pesticides
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• A01N 25/12 - Poudres ou granulés
• A61K 33/06 - Aluminium, calcium ou magnésium; Leurs composés
• A61K 33/32 - Manganèse; Ses composés
• A61K 33/30 - Zinc; Ses composés
• A61K 33/26 - Fer; Ses composés
• A61K 9/50 - Microcapsules
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges

Abrégé

The present disclosure provides antigen-binding molecules that bind to CD30, having novel biophysical and/or functional properties as compared to antigen-binding molecules disclosed in the prior art. Also provided is a chimeric antigen receptor (CAR) comprising the novel CD30-specific antigen-binding molecules. Also provided is a nucleic acid or plurality of nucleic acids encoding said antigen-binding molecule or CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p.ex. médicaments pour le traitement du rejet de greffe

Abrégé

Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 35/00 - Agents anticancéreux
• C07K 16/46 - Immunoglobulines hybrides

Abrégé

We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

MalasseziaMalassezia species.

Classes IPC  ?

• C12P 7/24 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carbonyle
• C12N 1/16 - Levures; Leurs milieux de culture
• C12N 15/00 - Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p.ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
• C12R 1/645 - Champignons

Abrégé

Disclosed are modified galactose oxidase variants with enhanced protein expression, solubility, thermal stability, and enzymatic activity, and reduced enantioselectivity compared to wild-type galactose oxidase or galactose oxidase variants known in the art, and methods of producing the same.

Classes IPC  ?

• C12P 7/26 - Cétones
• C12N 9/04 - Oxydoréductases (1.), p.ex. luciférase agissant sur des groupes CHOH comme donneurs, p.ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

The present disclosure provides an antigen-binding molecule comprising a single domain antibody sequence that binds to B7-H3. It also discloses a chimeric antigen receptor (CAR) construct comprising said antigen-binding molecule, encoding nucleic acid/expression vector and T cells expressing said CAR and the use of the CAR-expressing T cells in a method of medical treatment, prophylaxis, and treatment of cancer.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• G01N 33/563 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des fragments d'anticorps
• A61P 35/00 - Agents anticancéreux

Abrégé

The present application describes novel chimeric antigen receptor (CAR) constructs comprising novel spacer region sequences. Also provided are cells comprising the CAR, a nucleic acid or a plurality of nucleic acids encoding the CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p.ex. médicaments pour le traitement du rejet de greffe

Abrégé

The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules: amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

This invention relates to microbiome markers for healthy aging. There is provided, inter alia, a method of predicting or determining healthy aging in an individual, the method comprising: (a) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1A, wherein an enrichment of said microorganisms is indicative of healthy aging; and/or (b) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1 B, wherein a depletion of said microorganisms is indicative of healthy aging.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries

Abrégé

A photovoltachromic device is provided. The photovoltachromic device may include a photovoltaic cell, and a transparent-reflective switchable device in light communication with the photovoltaic cell. The transparent-reflective switchable device may be operable between a reflective mode in which light falling thereon is reflected to the photovoltaic cell, and a transmission mode in which light falling thereon is directed through the transparent-reflective switchable device.

Classes IPC  ?

• H02S 40/22 - Moyens réflecteurs ou concentrateurs de lumière
• H02S 20/20 - Structures de support directement fixées sur un objet inamovible
• G02F 1/157 - Association structurelle des cellules avec des dispositifs optiques, p.ex. des réflecteurs ou des dispositifs d’éclairage
• A01G 9/24 - Dispositifs de chauffage, d'aération, de régulation de la température ou d'irrigation dans les serres, les châssis ou les installations similaires
• A01G 9/22 - Stores ou jalousies de serres ou dispositifs similaires

Abrégé

A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.

Classes IPC  ?

• C08F 222/10 - Esters
• C08F 222/26 - Esters d'alcools non saturés
• C08F 2/06 - Solvant organique

Abrégé

A titanium-tantalum alloy having a titanium wt % ranging from 10% to 70% and wherein the titanium has a body centered cubic structure. A method of forming a titanium-tantalum alloy, the method comprising the steps of: (a) slicing a 3D CAD model of a part to be formed into a plurality of 2D image layers; (b) preparing a homogenous powder mixture of titanium powder and tantalum powder; (c) dispensing a layer of the powder mixture onto a processing bed; (d) performing powder bed fusion of the layer of the powder mixture according to one of the 2D image layers in one of: a vacuum environment and an inert gas environment; and performing steps (c) and (d) for each of the plurality of 2D image layers in succession.

Classes IPC  ?

• C22C 14/00 - Alliages à base de titane
• B33Y 10/00 - Procédés de fabrication additive
• C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B22F 1/05 - Poudres métalliques caractérisées par la dimension ou la surface spécifique des particules
• B22F 10/28 - Fusion sur lit de poudre, p.ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]

Abrégé

actinomycetesactinomycetesactinomycetes bacterium. In one embodiment, the metabolite is valinomycin, daidzein, fluvirucin, demethyllydicamycin, or TPU-0037 analogues A, C and D.

Classes IPC  ?

• C12N 15/76 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p.ex. Lactobacillus, Micromonospora pour Streptomyces
• C12R 1/465 - Streptomyces

Abrégé

There is provided a device for processing homomorphically encrypted data. The device includes: inter-line butterfly array blocks, each inter-line butterfly array block including inter-line modulus butterfly units, each inter-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same row of a matrix of input data points; intra-line butterfly array blocks, each intra-line butterfly array block including intra-line modulus butterfly units, each intra-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same column of the matrix of input data points; and a clock counter communicatively coupled to each inter-line butterfly array block and each intra-line butterfly array block, and configured to output a counter signal for controlling each inter-line butterfly array block and each intra-line butterfly array block to operate with single cycle initiation interval. The matrix of input data points includes columns of input data points, whereby parallel input data points derived from the homomorphically encrypted data are arranged into the columns of input data points. Furthermore, the inter-line butterfly array blocks and the intra-line butterfly array blocks are arranged in series to form a pipeline for processing the matrix of input data points.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• G06F 9/38 - Exécution simultanée d'instructions
• G06F 7/72 - Méthodes ou dispositions pour effectuer des calculs en utilisant une représentation numérique non codée, c. à d. une représentation de nombres sans base; Dispositifs de calcul utilisant une combinaison de représentations de nombres codées et non codées utilisant l'arithmétique des résidus

Abrégé

Various embodiments may relate to a piezoelectric device. The piezoelectric device may include a substrate, and a layered stacked arrangement anchored to the substrate. The layered stacked arrangement may include a piezoelectric layer. The stacked arrangement may also include a first electrode on a first side of the piezoelectric layer. The stacked arrangement may further include a second electrode on a second side of the piezoelectric layer opposite the first side. The piezoelectric layer may include a first region including one or more dipole domains of a first type, and one or more dipole domains of a second type. The first electrode may be at least partially in contact with the first region and at least partially in contact with the second region.

Classes IPC  ?

• H10N 30/20 - Dispositifs piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique, p.ex. fonctionnant comme actionneurs ou comme vibrateurs
• H10N 30/853 - Compositions céramiques
• H10N 30/076 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par dépôt de couches piézo-électriques ou électrostrictives, p.ex. par impression par aérosol ou par sérigraphie par dépôt en phase vapeur

Abrégé

Various embodiments refer to a light modulating device. The device may include a first support comprising a first photovoltaic cell on a surface and a first light-reflector on an opposing surface, and a second support comprising a second photovoltaic cell on a surface and second light-reflector on an opposing surface. The first support and the second support may be pivotably coupled to each other along an edge portion of the respective support, and movable between a collapsed position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell are opposed and inwardly facing and an extended position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell lie substantially in the same plane, to modulate transmission of light.

Classes IPC  ?

• H02S 20/30 - Structures de support mobiles ou réglables, p.ex. pour réglage de l’angle
• H02S 30/20 - Modules PV escamotables ou pliables
• F24S 30/48 - Agencements pour mouvoir ou orienter des modules de collecteurs de chaleur solaire pour le déplacement en rotation avec trois axes de rotation ou plus ou avec de multiples degrés de liberté
• A01G 9/24 - Dispositifs de chauffage, d'aération, de régulation de la température ou d'irrigation dans les serres, les châssis ou les installations similaires
• A01G 9/22 - Stores ou jalousies de serres ou dispositifs similaires

Abrégé

There is provided a method of converting polypropylene (PP) to oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures, the method comprising: oxidizing a PP containing source in the presence of a catalyst to obtain OPP; dissolving the OPP in a first liquid to obtain a dissolved solution of OPP; and precipitating OPP micro-sized particles having hierarchical nanostructures from the dissolved solution of OPP by adding the dissolved solution of OPP to a second liquid. Also provided is a material comprising oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures.

Classes IPC  ?

• C08F 10/06 - Propène
• C08J 11/08 - Récupération ou traitement des résidus des polymères sans réaction chimique utilisant des solvants sélectifs des constituants polymères
• C08J 3/14 - Pulvérisation ou granulation par précipitation à partir de solutions
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures

Abrégé

The invention relates generally to field of cancer biology. Provided herein are methods of inhibiting epithelial- mesenchymal transition (EMT) and for inhibiting or preventing metastasis in a cancer cell, the methods comprising contacting the cancer cell with an effective amount of a histone deacetylase 6 (HDAC6) inhibitor and a glycogen synthase kinase-3[3 (GSK30) inhibitor. Methods of screening for an inhibitor of EMT comprising a reporter cell line, which comprises a ZEB1 inducible construct, and an epithelial gene reporter construct are also provided herein.

Classes IPC  ?

• A61K 31/195 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe amino
• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
• A61P 35/00 - Agents anticancéreux

Abrégé

A sound absorption material and a method (10) of fabricating a sound absorption material are provided. The method (10) includes preparing (12) a first precursor solution or suspension of one of a first triboelectric material and a second triboelectric material; and forming (16) a porous structure by using the first precursor solution or suspension in one of a templating technique with a second precursor solution or suspension of the other one of the first and second triboelectric material, an immersion technique with the other one of the first and second triboelectric materials, and an electrospinning technique with the other one of the first and second triboelectric materials. The porous structure includes a hybrid composite of the first triboelectric material having a first charge affinity and the second triboelectric material having a second charge affinity, wherein the first charge affinity is greater than the second charge affinity.

Classes IPC  ?

• G10K 11/162 - Sélection de matériaux
• G10K 11/165 - Sélection de matériaux de particules dans une matrice
• E04B 1/84 - Eléments absorbant le son

Abrégé

The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

Various embodiments may relate to an optical system. The optical system may include a plurality of color filters, a first color filter of the plurality of color filters configured to select light of different wavelength ranges representing different color channels. The optical system may also include a plurality of metalenses, each of the plurality of metalenses associated with a respective color channel of the plurality of color channels. Each of the plurality of metalenses may have a focal length, the plurality of metalenses having equal focal lengths such that the different color channels are combined on a common focal plane to form a multi-color image. Each of the plurality of metalenses may include a plurality of nanostructures, have a (FOV) field of view of more than 30 degrees, and a desired working spectral bandwidth dependent on an extended depth of focus, a central wavelength of the associated color channel, and the focal length at the central wavelength.

Classes IPC  ?

• G02B 1/00 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques
• H04N 23/10 - Caméras ou modules de caméras comprenant des capteurs d'images électroniques; Leur commande pour générer des signaux d'image à partir de différentes longueurs d'onde
• B82Y 20/00 - Nano-optique, p.ex. optique quantique ou cristaux photoniques
• H04N 23/55 - Pièces optiques spécialement adaptées aux capteurs d'images électroniques; Leur montage

Abrégé

The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.

Classes IPC  ?

• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61P 35/00 - Agents anticancéreux

Abrégé

There is provided a device for vascularising a cell aggregate, the device comprising: a matrix region configured to contain a gel-like matrix and cells that form a vasculature network within th ematrix region. The matrix region having at least one opening for positioning the cell aggregate therein based on a desired three-dimensional spatial location; and one or more fluidic regions configured to contain a supporting fluid that is capable of supporting vascularisation of the cell aggregate, the one or more fluidic regions being in fluid communication with the matrix region, wherein a flow passage from the one or more fluidic regions to a gel-like matrix disposed in the matrix region is configured to allow three-dimensional vascularisation around the cell aggregate and perfusion of the vasculature once formed. There is also provided a chip comprising a plurality of the device as disclosed herein and a method for vascularising a cell aggregate.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains

Abrégé

Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.

Classes IPC  ?

• H10N 30/067 - Formation d’électrodes à une seule couche de parties piézo-électriques ou électrostrictives multicouches
• H10N 30/87 - Dispositifs piézo-électriques ou électrostrictifs - Détails de structure Électrodes ou interconnexions, p.ex. connexions électriques ou bornes
• H03H 9/17 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails de réalisation de résonateurs se composant de matériau piézo-électrique ou électrostrictif ayant un résonateur unique
• H10N 30/07 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support
• H03H 3/02 - Appareils ou procédés spécialement adaptés à la fabrication de réseaux d'impédance, de circuits résonnants, de résonateurs pour la fabrication de résonateurs ou de réseaux électromécaniques pour la fabrication de résonateurs ou de réseaux piézo-électriques ou électrostrictifs

Abrégé

A neural processing core for a neural network is provided, which includes: a synaptic memory array including synaptic memory cells arranged in a plurality of memory cell rows and columns; a plurality of first input activation lines connected to the plurality of memory cell rows, respectively, of the synaptic memory array and configured to receive a plurality of first input activation signals, respectively, to the plurality of memory cell rows; and a plurality of first sensing lines connected to the plurality of memory cell columns, respectively, of the synaptic memory array and configured to output a plurality of first analog electrical signals, respectively, from the plurality of memory cell columns. In particular, the neural processing core is configured to control the synaptic memory cells of the synaptic memory array in a column-wise manner. There is also provided a corresponding method of operating the neural processing core for a neural network.

Classes IPC  ?

• G06N 3/065 - Moyens analogiques
• G11C 11/54 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments simulateurs de cellules biologiques, p.ex. neurone

Abrégé

Disclosed is an expression system for an antigen binding molecule and the uses thereof.

Classes IPC  ?

• C07K 16/46 - Immunoglobulines hybrides
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

Antigen binding molecules capable of binding to calnexin (CNX) are disclosed herein. Also disclosed are chimeric antigen receptors, antibody-drug conjugates, and compositions comprising such antigen binding molecules, as well as nucleic acids, vectors and cells. Uses and methods involving antigen binding molecules capable of binding to calnexin (CNX) are also disclosed.

Classes IPC  ?

• C07K 16/40 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre des enzymes
• A61P 35/00 - Agents anticancéreux
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p.ex. arthrites, arthroses

Abrégé

Various embodiments may relate to an optical system. The optical system may include a laser source for emitting one or more laser beams. The optical system may also include a metalens, a first stage mounting the metalens, a first motor configured to move the first stage, a second stage for holding a sample, and a second motor configured to move the second stage. The optical system may include an objective, a third stage configured to hold the objective, and a third motor configured to move the third stage. The optical system may also include a detector and a screen including or defining a pinhole, the screen arranged between the objective and the detector. The optical system may also include a processor in electrical communication with the first motor, the second motor and the third motor.

Classes IPC  ?

• G03F 7/20 - Exposition; Appareillages à cet effet
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet

Abrégé

BRD4BRD4CHEK1CHEK1CHEK1 gene. The invention also relates to the use of SSOs as therapeutic candidates for treating Myc-driven cancers.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61P 35/00 - Agents anticancéreux

Abrégé

A method of identifying one or more bacteria from a sample, wherein the one or more bacteria is suspected to be present in the sample, is provided. The method may include providing an aqueous suspension comprising a bacteria-SERS nanoparticle complex, wherein the bacteria-SERS nanoparticle complex comprises (i) a SERS nanoparticle and (ii) the one or more bacteria suspected to be present in the sample; depositing the aqueous suspension comprising the bacteria-SERS nanoparticle complex on a substrate having structures coated with a SERS-active material to dispose the bacteria-SERS nanoparticle complex on the substrate; irradiating the bacteria-SERS nanoparticle complex disposed on the substrate with laser to generate one or more SERS signals; having a SERS-spectroscopic module operable to render one or more SERS spectral data corresponding to the one or more SERS signals; and having a process module operable to identify the presence or absence of the one or more bacteria from the one or more SERS spectral data.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
• G01N 21/65 - Diffusion de Raman

Abrégé

This document describes a spatial light modulator that comprises a pixel array having a plurality of pixels whereby each pixel in this array is communicatively coupled to a digital pixel circuit which are in turn all coupled to a bit-plane control circuit. The bit-plane control circuit is configured to generate, using a Pulse Code Modulation (PCM) algorithm, bit-plane signals that are used to control the sample and hold functions performed by each of the digital pixel circuits so that the pixel array may carry out its scanning function accurately and in a power efficient manner.

Classes IPC  ?

• G11C 11/418 - Circuits d'adressage
• G02F 1/133 - Dispositions relatives à la structure; Excitation de cellules à cristaux liquides; Dispositions relatives aux circuits
• G02F 1/1343 - Electrodes
• G02F 1/1368 - Cellules à adressage par une matrice active dans lesquelles l'élément de commutation est un dispositif à trois électrodes
• G09G 3/36 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante utilisant des cristaux liquides

Abrégé

The present invention relates to splice-switching oligonucleotides (SSOs) capable of altering the slicing of a pre-mRNA encoding a variant of the SLC25A13 gene, as well as the use of the same SSOs for treating citrin deficiency. In an embodiment, a SSO that binds to a site within a target region present on a pre-mRNA transcript of the SLC25A13 gene, wherein the binding of the SSO induces the exclusion of SLC25A13-PE5 from a mature mRNA transcript of the SLC25A13 gene. In another embodiment, the target region having at least 95% sequence identity to SEQ ID NO: 28.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme

Abrégé

An analyser (10, 100) for pollutant detection and a computer-implemented method (200) for pollutant detection are provided. The analyser (10, 100) includes one 5 or more electrochemical detection units (12, 102), one or more processors (14), a non-transitory computer-readable memory (16) and a display (18). Each of the one or more electrochemical detection units (12, 102) is configured to receive a control voltage signal according to a pollutant-specific detection protocol and output a measured current signal based on a measured electrical current from an electrode chip (20). The non-transitory 0 computer-readable memory (16) stores a detection protocol for each of a plurality of pollutants, a characterisation curve for each of the pollutants and computer program instructions executable by the one or more processors (14) to perform operations for pollutant detection, the operations comprising: identifying a current peak in the measured current signal; determining a peak intensity corresponding to the identified current peak; 5 and determining a concentration of a selected pollutant from the characterisation curve of the selected pollutant based on the determined peak intensity. The display (18) is configured to display the concentration of the selected pollutant.

Classes IPC  ?

• G01N 27/416 - Systèmes
• G01N 27/30 - Composants de cellules électrolytiques Électrodes, p.ex. électrodes pour tests; Demi-cellules

Abrégé

A system for classification of basal cell carcinoma (BCC) and a method of classifying basal cell carcinoma (BCC) may be provided, the system comprising a processing module configured to receive an input image sequence comprising a plurality of images; and a prediction module coupled to the processing module, the prediction module comprising a hierarchical ensemble structure of a plurality of classification models; wherein the processing module is configured to process each image as a whole image to obtain a plurality of first sub-sections and to further process each first sub-section to obtain a corresponding plurality of second sub-sections; further wherein the processing module is configured to transmit the each first sub-section to a first classification model of the prediction module trained to process the first sub-sections and to transmit each of the corresponding plurality of second sub- sections to a second classification model of the prediction module trained to process the second sub-sections, further wherein the prediction module is configured to determine a probability of BCC of the each image of the input image sequence based on a plurality of respective block prediction results corresponding to the first sub-sections of the each image; and further wherein the prediction module is configured to determine a BCC classification of the input image sequence based on the determined probability of BCC of each image of the input image sequence.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06N 20/20 - Techniques d’ensemble en apprentissage automatique
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
• G16B 40/00 - TIC spécialement adaptées aux biostatistiques; TIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p.ex. extraction de connaissances ou détection de motifs

Abrégé

There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.

Classes IPC  ?

• C08G 81/02 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p.ex. polymères séquencés au moins un des polymères étant obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carbone
• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle

Abrégé

A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.

Classes IPC  ?

• B25J 15/12 - Têtes de préhension avec des éléments en forme de doigts avec des éléments en forme de doigts flexibles
• B25J 15/10 - Têtes de préhension avec des éléments en forme de doigts avec au moins trois éléments en forme de doigts
• B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion

Abrégé

There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule. There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.

Classes IPC  ?

• C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p.ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle

Abrégé

The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

Classes IPC  ?

• C07D 491/08 - Systèmes pontés
• C07D 215/233 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 4
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 451/06 - Atomes d'oxygène
• C07D 451/14 - Composés hétérocycliques contenant des systèmes cycliques aza-8 bicyclo [3.2.1] octane, aza-9 bicyclo [3.3.1] nonane ou oxa-3 aza-9 tricyclo [3.3.1.02,4] nonane, p.ex. alcaloïdes du tropane ou du granatane, scopolamine; Leurs acétals cycliques  contenant des systèmes cycliques aza-9 bicyclo [3.3.1] nonane, p.ex. granatane, aza-2 adamantane; Leurs acétals cycliques

Abrégé

The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; iincubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The disclosure relates to methods of treatment and methods of identifying subjects for such treatment based on levels of pirin and/or iron in samples from the subject. In one embodiment, the subject is suffering from cancer, such as colorectal cancer, hemochromatosis or anaemia. In one embodiment, the treatment includes administration of iron chelator or pirin inhibitor.

Classes IPC  ?

• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/84 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des composés inorganiques ou le pH
• A61K 31/5375 - 1,4-Oxazines, p.ex. morpholine
• A61K 31/16 - Amides, p.ex. acides hydroxamiques
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnie; Test des temps de réaction
• A61B 5/378 - Stimuli visuels

Abrégé

The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.

Classes IPC  ?

• C07K 14/335 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Lactobacillus (G)
• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase

Abrégé

A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.

Classes IPC  ?

• C09C 3/06 - Traitement par des composés inorganiques
• C09D 7/62 - Adjuvants non macromoléculaires inorganiques modifiés par traitement avec d’autres composés
• C09D 7/40 - Adjuvants
• C09D 5/33 - Peintures réfléchissantes
• C09C 1/28 - Composés du silicium

Abrégé

There is provided a nucleic acid construct comprising one or more internal ribosome entry site (IRES), one or more gene of interest, and a pair of site-specific recombinase, wherein the gene of interest is a heparan sulfate variant gene, a heparan sulfate modification enzyme gene, and/or a heparan sulfate scaffold protein gene. Also disclosed are a vector, a host cell and / or cell line, recombinant heparan sulfates, methods, kits for use thereof.

Classes IPC  ?

• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes ; Leurs dérivés
• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées

Abrégé

The present invention relates to a koji mold fermentation product of a cereal-derived material which has an arabinan concentration of 5 mg/g or less. The present invention also relates to a method for producing a koji mold fermentation product of a cereal-derived material, said method comprising treating the cereal-derived material with an arabinase and a cellulase and fermenting the thus treated material using koji mold.

Classes IPC  ?

• C12P 1/02 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymes; Procédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des champignons
• C12N 1/14 - Champignons; Leurs milieux de culture
• A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques
• C12N 9/42 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2) agissant sur les liaisons bêta-glucosidiques-1, 4, p.ex. cellulase

Abrégé

The present disclosure concerns enzymes and their uses in biocatalytic halogenation of pyrrolic heterocycles thereof. The method of halogenating a 2', 3' and/or 5' substituted N-heteroaryl or a derivative thereof comprises contacting the N-heteroaryl or derivative thereof with a halogen and a flavin-dependent halogenase under co-enzyme regeneration conditions in order for the halogen to be substituted at a 4' position on the N-heteroaryl or derivative thereof.

Classes IPC  ?

• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12P 13/00 - Préparation de composés organiques contenant de l'azote

Abrégé

The present invention relates, in general terms, to TEAD targeting compounds and 5 methods thereof.

Classes IPC  ?

• C07D 277/46 - Radicaux amino ou imino acylés par les acides carboxyliques ou par leurs analogues du soufre ou de l'azote
• C07D 213/75 - Radicaux amino ou imino, acylés par un acide carboxylique, par l'acide carbonique ou par leurs analogues du soufre ou de l'azote, p.ex. des carbamates
• C07D 231/40 - Atomes d'azote acylés sur ledit atome d'azote
• C07D 249/06 - Triazoles-1, 2, 3; Triazoles-1, 2, 3 hydrogénés avec des radicaux aryle liés directement aux atomes du cycle
• A61K 31/10 - Sulfures; Sulfoxydes; Sulfones
• A61K 31/415 - 1,2-Diazoles
• A61K 31/426 - 1,3-Thiazoles
• A61P 35/00 - Agents anticancéreux

Abrégé

Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.

Classes IPC  ?

• G01N 21/3518 - Dispositifs utilisant des techniques de corrélation à filtres de gaz; Dispositifs utilisant des techniques de modulation de la pression des gaz
• G01N 21/05 - Cuvettes à circulation de fluides

Abrégé

The present disclosure provides an anti-bacterial peptide comprising ENOS or SPARCL1, or partial sequences thereof. The present disclosure also provides a conditioned cell culture media comprising the anti-bacterial peptide, wherein the conditioned cell culture media is made by culturing adipose-derived mesenchymal stem cells. The technology also relates to a method of treating infections using the peptides.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 31/04 - Agents antibactériens

Abrégé

The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/522 - Purines, p.ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p.ex. hypoxanthine, guanine, acyclovir

Abrégé

Described herein are compositions containing branched polyethylenimine and polypropylene glycol covalently bonded to the branched polyethyleneimine, where a molar ratio of the propylene glycol to the branched polyethylenimine is more than 3.35:1, and the polypropylene glycol is hydrophobic. The compositions may be used as a hydrogel and changes between a solution phase and a gel phase by changes in pH or temperature.

Classes IPC  ?

• C08G 71/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison uréide ou uréthane, autrement qu'à partir de radicaux isocyanate
• C08J 3/075 - Gels macromoléculaires
• C08G 81/00 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p.ex. polymères séquencés
• C08L 75/08 - Polyuréthanes à partir des polyéthers
• C08L 75/12 - Polyuréthanes à partir de composés contenant de l'azote et un hydrogène actif, l'atome d'azote ne faisant pas partie du groupe isocyanate
• C08G 73/04 - Polyamines dérivées d'alkylène-imines
• C08G 65/02 - Composés macromoléculaires obtenus par des réactions créant une liaison éther dans la chaîne principale de la macromolécule à partir d'éthers cycliques par ouverture d'un hétérocycle

Abrégé

An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.

Classes IPC  ?

• B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p.ex. avec des séparateurs électrostatiques; Ensembles ou systèmes de plusieurs centrifugeurs
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• B01D 21/26 - Séparation du sédiment avec emploi de la force centrifuge
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/26 - Inoculateur ou échantillonneur
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01D 43/00 - Séparation de particules de liquides, ou de liquides de solides, autrement que par sédimentation ou filtration

Abrégé

There is provided a ribozyme comprising: a) one or more catalytic domains capable of switching between an active state and an inactive state; b) one or more releasable RNA segments, wherein each of said releasable RNA segments is flanked by two ribozyme cleavage sites, wherein cleavage at each cleavage site is catalysed by at least one of the one or more catalytic domains in an active state; c) one or more trigger-binding domains, each of which is for the binding of a trigger nucleic acid molecule; wherein each of the one or more catalytic domains is linked to one of the one or more trigger-binding domains; wherein the catalytic domain is in an inactive state when the trigger-binding domain linked to said catalytic domain is not bound by the trigger nucleic acid molecule, and wherein the catalytic domain is in an active state when the trigger-binding domain linked to said catalytic domain is bound by the trigger nucleic acid molecule; and wherein when both cleavage sites flanking a releasable RNA segment are cleaved when catalysed by the one or more catalytic domains, the one or more releasable RNA segment is released from the ribozyme. Also disclosed are methods of detecting presence of a trigger nucleic acid molecule in a sample, methods of detecting presence of a sequence or mutation of interest on an nucleic acid of interest in a sample, and kits comprising the ribozymes thereof.

Classes IPC  ?

• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• C12Q 1/6816 - Tests d’hybridation caractérisés par les moyens de détection
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.

Classes IPC  ?

• A23D 9/04 - Traitement
• A23D 9/007 - Autres huiles ou graisses comestibles, p.ex. huiles pour cuisson caractérisées par des ingrédients autres que des triglycérides d'acides gras
• A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles, contenant une phase aqueuse, p.ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras

Abrégé

There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.

Classes IPC  ?

• G06N 3/088 - Apprentissage non supervisé, p.ex. apprentissage compétitif
• G06N 3/049 - Réseaux neuronaux temporels, p.ex. éléments à retard, neurones oscillants ou entrées impulsionnelles

Abrégé

The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis. The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.

Classes IPC  ?

• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose

Abrégé

A closure for a sample tube comprises a reaction vessel. The reaction vessel comprises: at least one microfluidic mixing channel having an inlet and an outlet; at least one reaction chamber in fluid communication with the inlet and the outlet; an inlet chamber proximate the inlet of the at least one microfluidic mixing channel for introducing a portion of a sample solution from the sample tube into the at least one reaction chamber under hydrostatic pressure; and a diffusion-control feature for limiting egress of fluid from the outlet such that the portion of the sample solution introduced to the at least one reaction chamber is partitioned from the rest of the sample solution.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The present invention relates to a method comprising the detection of LOC105375914 RNA in a glioma sample obtained from a subject, wherein an elevated level of LOC105375914 RNA as compared to a reference indicates that the subject has a high grade glioma, has a likelihood of resistance to chemotherapy, has a likelihood of recurrence, and/or is likely to have a poor prognosis. The present invention also relates to a method of treating a glioma expressing LOC105375914 RNA in a subject by administering an inhibitor of the LOC-DEAH-box helicase 15 (DHX15) complex to the subject.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/404 - Indoles, p.ex. pindolol
• A61P 35/00 - Agents anticancéreux

Abrégé

There is provided a regenerative material for skin, bone and/or cartilage tissue regeneration, the material comprising, a hyaluronic acid-based synthetic copolymer having one or more repeating units represented by general formula (Vlll-a). Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, hyaluronic acid-based macromolecule, and a method of preparing said hyaluronic acid-based macromolecule.

Classes IPC  ?

• C08G 61/12 - Composés macromoléculaires contenant d'autres atomes que le carbone dans la chaîne principale de la macromolécule
• C08L 65/00 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principale; Compositions contenant des dérivés de tels polymères 
• A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p.ex. polyphosphates inorganiques
• A61K 31/728 - Acide hyaluronique
• A61L 15/26 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone; Leurs dérivés
• A61L 15/28 - Polysaccharides ou leurs dérivés

Abrégé

Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• C12N 5/0735 - Cellules souches embryonnaires; Cellules germinales embryonnaires
• C12N 5/074 - Cellules souches adultes
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

A method of producing a silicalite membrane, which includes heating an aqueous solution that includes a dopant precursor and structure-directing template agents to form silicalite seeds incorporated with a dopant, depositing a buffer layer on a ceramic substrate prior to depositing the silicalite seeds on the buffer layer, contacting the ceramic substrate with a solution including the silicalite seeds to form a silicalite layer from the silicalite seeds on the ceramic substrate, and removing the structure-directing template agents to form the silicalite membrane, where the silicalite layer includes silicalite crystals incorporated with a dopant and each of the silicalite crystals has a hollow structure which forms the pores of the silicalite layer. The silicalite membrane includes a ceramic substrate having a buffer layer formed thereon, and a silicalite layer formed on the buffer layer, where the silicalite layer includes silicalite crystals incorporated with a dopant.

Classes IPC  ?

• B01D 71/02 - Matériaux inorganiques
• B01D 69/10 - Membranes sur support; Supports pour membranes
• B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
• B01D 69/04 - Membranes tubulaires

Abrégé

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

Classes IPC  ?

• C08L 79/02 - Polyamines

Abrégé

Immune cells comprising modification to increase the expression or activity of SERPINB9 are disclosed. Also disclosed are compositions comprising such cells and methods of using such cells and compositions.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• C07K 14/81 - Inhibiteurs de protéase

Abrégé

Various embodiments may relate to a fluid extraction apparatus. The fluid extraction apparatus may include a syringe holder configured to hold one or more syringes, and a first linear actuator configured to move the syringe holder into a position for loading of a syringe of the one or more syringes. The fluid extraction apparatus may also include a stand, a rotary platform on the stand, and a vial holder on the rotary platform. The fluid extraction apparatus may also include a cap gripper on the rotary platform, a rotary actuator configured to rotate the rotary platform between a first configuration and a second configuration, a second linear actuator configured to actuate a plunger of the syringe such that the syringe extracts at least the portion of the fluid, and a controller configured to control the first linear actuator, the second linear actuator, and the rotary actuator.

Classes IPC  ?

• B65B 3/00 - Emballage de matériaux plastiques, de semi-liquides, de liquides ou de liquides et solides mélangés, dans des réceptacles ou récipients individuels, p.ex. dans des sacs ou sachets, boîtes, cartons, bidons ou pots

Abrégé

An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

Classes IPC  ?

• G01N 21/3563 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solides; Préparation des échantillons à cet effet
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
• G01N 21/359 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche

Abrégé

Various embodiments may relate to an electro-optic modulator. The electro-optic modulator may include a waveguide configured to carry optical light along a longitudinal length of the waveguide. The electro-optic modulator may also include a first electrically conductive sub-wavelength grating on a first side of the waveguide, the first electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may further include a second electrically conductive sub-wavelength grating on a second side of the waveguide opposite the first side, the second electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may be configured to modulate the optical light upon application of a potential difference between the first electrically conductive sub-wavelength grating and the second electrically conductive sub-wavelength grating based on Pockels effect.

Classes IPC  ?

• G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
• G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence

Abrégé

The present invention is in the field of molecular diagnostics and is directed to the detection of target nucleic acids in a sample using a modified CRISPR-Dx system, typically with prior amplification of the target. The modified CRISPR-Dx system comprising an engineered E174R/S542R/K548R variant of AsCas12a, wherein when get activated indiscriminately cleaves at least one detection reagent to generate signal. In one embodiment, the target nucleic acid is SARS-CoV-2 RNA.

Classes IPC  ?

• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.

Classes IPC  ?

• G06T 7/10 - Découpage; Détection de bords
• G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
• G06T 7/64 - Analyse des attributs géométriques de la convexité ou de la concavité
• G06T 7/66 - Analyse des attributs géométriques des moments d'image ou du centre de gravité
• G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p.ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]; Caractéristiques régionales saillantes
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06T 7/00 - Analyse d'image

Abrégé

There is provided a composition comprising a slurry of capsules, the capsules having shells comprising silica and said shells encapsulating phase change materials (PCM); and a cementitious binder. There is also provided a method for preparing said composition.

Classes IPC  ?

• C09K 5/02 - Substances qui subissent un changement d'état physique lors de leur utilisation
• C04B 22/06 - Oxydes; Hydroxydes
• C04B 24/04 - Acides carboxyliques; Leurs sels, anhydrides ou esters
• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p.ex. séchage, pulvérisation
• C04B 24/38 - Polysaccharides ou leurs dérivés

Abrégé

The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
• B29C 33/42 - Moules ou noyaux; Leurs détails ou accessoires caractérisés par la forme de la surface de moulage, p.ex. par des nervures ou des rainures
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

Methods and systems for facilitating analysis of a skin condition are provided. The methods apply a deep neural network (DNN) to a digital skin image to identify or prepare a digital lesion skin image for further processing. Further processing can involve calculating an asymmetry (A) score based on a feature vector produced by combining feature vectors derived from the digital lesion skin image, calculating a border score based on the regularity of a lesion or skin condition, calculating a colour score based on colours detected in the digital lesion skin image, calculating a dermatoscopic score based on a presence of dermatoscopic features or structures in a digital skin lesion image, and finally calculating a final score based on the asymmetry, border, colour and dermatoscopic scores, the final score indicating a likelihood of the skin condition.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
• G06V 10/28 - Quantification de l’image, p.ex. seuillage par histogramme visant à discriminer entre les formes d’arrière-plan et d’avant-plan
• G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p.ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]; Caractéristiques régionales saillantes
• G06V 10/56 - Extraction de caractéristiques d’images ou de vidéos relative à la couleur

Abrégé

A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).

Classes IPC  ?

• G10K 11/165 - Sélection de matériaux de particules dans une matrice
• C09D 7/61 - Adjuvants non macromoléculaires inorganiques
• C09D 7/40 - Adjuvants
• C09D 5/24 - Peintures électriquement conductrices
• C09D 163/00 - Compositions de revêtement à base de résines époxy; Compositions de revêtement à base de dérivés des résines époxy
• C09D 137/00 - Compositions de revêtement à base d'homopolymères ou de copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un hétéroc; Compositions de revêtement à base de dérivés de tels polymères
• C09D 123/08 - Copolymères de l'éthylène
• C09D 113/00 - Compositions de revêtement à base de caoutchoucs contenant des groupes carboxyle

Abrégé

There is provided a polymer or derivative thereof comprising a plurality of active amine groups in the backbone, wherein the polymer is a reaction product of a reaction between one or more bis-carbonates and one or more amine compounds having at least two terminal amino groups. Also provided are use of the polymer or derivative thereof and a method of preparing the polymer or derivative thereof.

Classes IPC  ?

• C08G 71/04 - Polyuréthanes
• C11D 11/00 - Méthodes particulières pour la préparation de compositions contenant des mélanges de détergents
• C11D 3/00 - Autres composés entrant dans les compositions détergentes couvertes par le groupe
• C11D 3/37 - Polymères
• C10M 149/14 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone faisant intervenir une réaction de condensation
• A01N 47/12 - Dérivés de l'acide carbamique, c. à d. contenant le groupe —O—CO—N; Leurs thio-analogues contenant un groupe —O—CO—N, ou un de ses thio-analogues, non directement lié à un cycle et l'atome d'azote n'étant pas un chaînon d'un hétérocycle
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• B01D 53/62 - Oxydes de carbone
• B01D 53/78 - Procédés en phase liquide avec un contact gaz-liquide
• B01D 53/14 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption