AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Ding, Ning
Yin, Xuesong
Abstract
The present invention relates to an electrolyte comprising lithium difluoro(oxalate)borate (LiDFOB) and a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M, a rechargeable battery comprising the electrolyte as described herein, a cathode layer, an anode layer and a separator, and a method of preparing the electrolyte as described herein, comprising the step of dissolving LiDFOB in a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Liu, Tongming
Simon, Cool
Abstract
Disclosed herein are a method of identifying therapeutically potent mesenchymal stem cells (MSCs) and a method of distinguishing MSCs from human fibroblasts, comprising detecting HOXA9 expression in the cell. Also disclosed is a method of treating diseases in a subject in need of MSCs, comprising modifying MSCs to overexpress HOXA9 and administering the modified MSCs to the subject in need.
Agency for Science, Technology and Research (Singapore)
Inventor
Van Meurs, Martin
Nobbs, James David
Sugiarto, Sigit
Abstract
The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.
The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.
C07F 9/6568 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
4.
A HAND-HELD PROBE FOR A RAMEN SPECTROSCOPY SYSTEM AND A RAMEN SPECTROSCOPY SYSTEM
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Olivo, Malini
Bi, Renzhe
Zhang, Ruochong
Qi, Yi
Rajarahm, Poongkulali
Abstract
In some aspects, a hand-held probe for a Raman spectroscopy system is provided. The hand-held probe includes an excitation module, configured to emit a light beam along a light path; a beam splitter, oriented to reflect the light beam along the observation axis; an objective module, configured to receive the reflected light beam and transmit the reflected light beam to an object so as to generate a scattered light beam by the object, and configured to receive and transmit the scattered light beam to the beam splitter; a focusing mirror, configured to focus the refracted light beam from the beam splitter to a focus so as to generate a focused light beam; and an emission module, disposed at the focus and configured to receive the focused light beam, wherein the emission module is disposed at a same side as the excitation module with respect to the observation axis.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Lee, Yin Loon
Burke, Brian, Edmund
Chiam, Keng Hwee
Jun, Myeongjun
Stewart, Colin
Wong, Xianrong
Raghavan, Srikala
Banerjee, Avinanda
Ng, Krystle, Joy
Abstract
The present invention relates to cell biology. In particular, the present invention teaches methods of contacting the cells with a LING complex inhibitor to inhibit durotaxis and, in consequence, reduce fibrosis and metastasis. Methods of treating wound healing are also disclosed herein.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
6.
A METHOD OF DETECTING THE PRESENCE OF A NUCLEIC ACID
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Hirao, Ichiro
Hirao, Michiko
Abstract
There is provided a method detecting the presence of a nucleic acid in a sample, the method comprises performing an amplification reaction on the sample in the presence of a proofreading polymerase and a primer with a 2'-sugar modification. Also provided is a method of identifying a disease in subject and a kit for detecting a nucleic acid in a sample.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Goh, Simin Shermin
Goh, Wei Peng
Seah, Kim Kui Georgina Estelle
Neo, Zhi Hao
Ng, Shi Hoe
Abstract
There are provided a method of treating a solid contact and a solid contact obtained from the method. There are also provided a method of preparing an ion-selective electrode and an ion-selective electrode prepared by the method. There is further provided a method of sensing an ion in a sample.
G01N 27/333 - Ion-selective electrodes or membranes
H01B 1/12 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Kiryukhin, Maxim
Lim, Su Hui
Lau, Hooi Hong
Upton, Zee
Fernandez, Melissa Laura
Abstract
There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wong, Fong Tian
Ching, Kuan Chieh
Ng, Siew Bee
Lim, Yee Hwee
Kanaga Sundaram, Yoganathan S/o
Abstract
The present disclosure concerns a method of biosynthesizing an antimicrobial compound of Formula (I), the method comprising culturing a microbial cell that is engineered to overexpress fatty-acyl CoA synthase (FAS) or RedD; and isolating the antimicrobial compound of Formula (I) that is produced by the microbial cell; wherein the biosynthesis of antimicrobial compound of Formula (I) is upregulated by at least about 2-fold compared to a tetramic acid analogue derived from a wild type microbial cell. The present disclosure also concerns a compound of Formula (I) and their use in treating a microbial disease or condition.
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NANYANG TECHNOLOGICAL UNIVERSITY (Singapore)
Inventor
Wong, Ten It
Zhou, Xiaodong
Ge, Liya
Lisak, Grzegorz
Zhao, Ke
Abstract
A leaching device (10) is provided. The leaching device (10) includes a motor (12) and a receptacle (14) rotatably coupled to the motor (12), the receptacle (14) being configured to receive a sample container. A plurality of ultrasonic transducers (16) is 5 attached to the receptacle (14). An ultrasonic generator (18) is coupled to the ultrasonic transducers (16). When in use, the ultrasonic generator (18) is configured to energise the ultrasonic transducers (16) to radiate ultrasonic waves to sonicate a sample in the sample container received in the receptacle (14). A controller (20) is configured to control operation of the motor (12) and the ultrasonic generator (18), the motor (12) and the 0 ultrasonic generator (18) being simultaneously operable.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Tan, Hong Meng Benjamin
Meftah, Souhail
Aung, Khin Mi Mi
Abstract
In some aspects, a set of input elements is obtained, at a rectified linear unit-activated neuron of a neural network based, on input data at the neuron. A first group and a second group of input elements are generated based on the set of input elements. The first group and the second group of input elements are associated with first weight elements and second weight elements, respectively. A first value is generated based on the first group of input elements and the first weight elements. A second value is generated based on the second group of input elements and the second weight elements. A third value and a fourth value are respectively generated based on a first operation and a second operation on the first value and the second value. An output of the neuron is generated based on the third value and the fourth value.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wang, Cheng-I
Lim, Pei Yin
Abstract
There is provided an antigen binding protein that specifically binds to yellow fever virus wherein the antigen binding protein comprises (1) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 1-3 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 7-9; or (2) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 4-6 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 10-12. Also disclosed are polynucleotides, vectors, and host cells expressing the antigen binding protein thereof. Also disclosed are methods of detecting, kits, and methods of preventing or treating a yellow fever virus infection in a subject in need thereof.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Jin, Chao
Chan, Fook Mun
Aung, Khin Mi Mi
Abstract
There is provided a method of privacy-preserving logistic regression training based on homomorphically encrypted ciphertexts. The method includes: obtaining a first packed ciphertext comprising at least a portion of a first training data sample packed into a first vector of slots thereof for training a privacy-preserving logistic regression model; obtaining a second packed ciphertext comprising a plurality of weights of the privacy-preserving logistic regression model packed into a first vector of slots thereof; determining at least a first output probability of the privacy-preserving logistic regression model based on the first packed ciphertext and the second packed ciphertext; and updating the plurality of weights based on the first output probability. There is also provided a corresponding system for privacy-preserving logistic regression training based on homomorphically encrypted data.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Zhang, Yugen
Wang, Jinquan
Abstract
There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Low, Lionel, Jianrong
Tan, Kar Wai
Ng, Chee Hoe
Kua, Lindsay
Abstract
The present disclosure provides antigen-binding molecules that bind to CD30, having novel biophysical and/or functional properties as compared to antigen-binding molecules disclosed in the prior art. Also provided is a chimeric antigen receptor (CAR) comprising the novel CD30-specific antigen-binding molecules. Also provided is a nucleic acid or plurality of nucleic acids encoding said antigen-binding molecule or CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Agency for Science, Technology and Research (Singapore)
Euchloe Bio Pte. Ltd. (Singapore)
Inventor
Brauer, Peter
Connolly, John Edward
Hopkins, Richard
Lai, Junyun
Low, Jianrong Lionel
Tan, Kar Wai
Wang, Cheng-I
Yeo, Siok Ping
Abstract
Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Lim, Yee Hwee
Tay, Wei Peng Dillon
Miyajima, Jhoann Margarette Tristeza
Maurer-Stroh, Sebastian
Yeo, Wan Lin
Ang, Ee Lui
Abstract
Disclosed are modified galactose oxidase variants with enhanced protein expression, solubility, thermal stability, and enzymatic activity, and reduced enantioselectivity compared to wild-type galactose oxidase or galactose oxidase variants known in the art, and methods of producing the same.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Low, Lionel Jianrong
Tan, Kar Wai
Yeo, Siok Ping
Koh, Xinyu
Kua, Lindsay, Hsien Pin
Abstract
The present disclosure provides an antigen-binding molecule comprising a single domain antibody sequence that binds to B7-H3. It also discloses a chimeric antigen receptor (CAR) construct comprising said antigen-binding molecule, encoding nucleic acid/expression vector and T cells expressing said CAR and the use of the CAR-expressing T cells in a method of medical treatment, prophylaxis, and treatment of cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Low, Lionel Jianrong
Tan, Kar Wai
Ng, Chee Hoe
Tan, Jin Wei
Abstract
The present application describes novel chimeric antigen receptor (CAR) constructs comprising novel spacer region sequences. Also provided are cells comprising the CAR, a nucleic acid or a plurality of nucleic acids encoding the CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Agency for Science, Technology and Research (Singapore)
Inventor
Quake, Stephen R.
Burkholder, William F.
Hong, Lewis Z.
Abstract
The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules: amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Png, Eileen
Ravikrishnan, Aarthi
Chng, Kern Rei
Nagarajan, Niranjan
Abstract
This invention relates to microbiome markers for healthy aging. There is provided, inter alia, a method of predicting or determining healthy aging in an individual, the method comprising: (a) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1A, wherein an enrichment of said microorganisms is indicative of healthy aging; and/or (b) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1 B, wherein a depletion of said microorganisms is indicative of healthy aging.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Jiang, Changyun
Goh, Wei Peng
Ang, Yong Long, Thomas
Tong, Shi Wun
Neo, Chi Jin Darren
Huang, Xiaohu
Abstract
A photovoltachromic device is provided. The photovoltachromic device may include a photovoltaic cell, and a transparent-reflective switchable device in light communication with the photovoltaic cell. The transparent-reflective switchable device may be operable between a reflective mode in which light falling thereon is reflected to the photovoltaic cell, and a transmission mode in which light falling thereon is directed through the transparent-reflective switchable device.
Agency for Science, Technology and Research (Singapore)
Inventor
Mothe, Srinivasa Reddy
Thoniyot, Praveen
Abstract
A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.
Agency for Science, Technology and Research (Singapore)
Inventor
Sing, Swee Leong
Yeong, Wai Yee
Wiria, Florencia Edith
Abstract
A titanium-tantalum alloy having a titanium wt % ranging from 10% to 70% and wherein the titanium has a body centered cubic structure. A method of forming a titanium-tantalum alloy, the method comprising the steps of: (a) slicing a 3D CAD model of a part to be formed into a plurality of 2D image layers; (b) preparing a homogenous powder mixture of titanium powder and tantalum powder; (c) dispensing a layer of the powder mixture onto a processing bed; (d) performing powder bed fusion of the layer of the powder mixture according to one of the 2D image layers in one of: a vacuum environment and an inert gas environment; and performing steps (c) and (d) for each of the plurality of 2D image layers in succession.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Tay, Wei Peng, Dillon
Lim, Yee Hwee
Wong, Fong Tian
Ng, Siew Bee
Kanagasundaram, Yoganathan
Abstract
actinomycetesactinomycetesactinomycetes bacterium. In one embodiment, the metabolite is valinomycin, daidzein, fluvirucin, demethyllydicamycin, or TPU-0037 analogues A, C and D.
C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Yang, Hong
Kang, Dee Meng
Al Badawi, Ahmad Qaisar Ahmad
Aung, Khin Mi Mi
Abstract
There is provided a device for processing homomorphically encrypted data. The device includes: inter-line butterfly array blocks, each inter-line butterfly array block including inter-line modulus butterfly units, each inter-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same row of a matrix of input data points; intra-line butterfly array blocks, each intra-line butterfly array block including intra-line modulus butterfly units, each intra-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same column of the matrix of input data points; and a clock counter communicatively coupled to each inter-line butterfly array block and each intra-line butterfly array block, and configured to output a counter signal for controlling each inter-line butterfly array block and each intra-line butterfly array block to operate with single cycle initiation interval. The matrix of input data points includes columns of input data points, whereby parallel input data points derived from the homomorphically encrypted data are arranged into the columns of input data points. Furthermore, the inter-line butterfly array blocks and the intra-line butterfly array blocks are arranged in series to form a pipeline for processing the matrix of input data points.
H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
G06F 9/38 - Concurrent instruction execution, e.g. pipeline, look ahead
G06F 7/72 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations using residue arithmetic
29.
PIEZOELECTRIC DEVICE AND METHOD OF FORMING THE SAME
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Ng, Eldwin Jiaqiang
Wang, Nan
Merugu, Srinivas
Sharma, Jaibir
Abstract
Various embodiments may relate to a piezoelectric device. The piezoelectric device may include a substrate, and a layered stacked arrangement anchored to the substrate. The layered stacked arrangement may include a piezoelectric layer. The stacked arrangement may also include a first electrode on a first side of the piezoelectric layer. The stacked arrangement may further include a second electrode on a second side of the piezoelectric layer opposite the first side. The piezoelectric layer may include a first region including one or more dipole domains of a first type, and one or more dipole domains of a second type. The first electrode may be at least partially in contact with the first region and at least partially in contact with the second region.
H10N 30/076 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by vapour phase deposition
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Jiang, Changyun
Goh, Wei Peng
Abstract
Various embodiments refer to a light modulating device. The device may include a first support comprising a first photovoltaic cell on a surface and a first light-reflector on an opposing surface, and a second support comprising a second photovoltaic cell on a surface and second light-reflector on an opposing surface. The first support and the second support may be pivotably coupled to each other along an edge portion of the respective support, and movable between a collapsed position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell are opposed and inwardly facing and an extended position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell lie substantially in the same plane, to modulate transmission of light.
F24S 30/48 - Arrangements for moving or orienting solar heat collector modules for rotary movement with three or more rotation axes or with multiple degrees of freedom
A01G 9/24 - Devices for heating, ventilating, regulating temperature, or watering, in greenhouses, forcing-frames, or the like
A01G 9/22 - Shades or blinds for greenhouses, or the like
31.
METHOD OF CONVERTING POLYPROPYLENE TO OXIDIZED POLYPROPYLENE MICRO-SIZED PARTICLES HAVING HIERARCHICAL NANOSTRUCTURES AND MATERIAL COMPRISING SAID PARTICLES
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Zhang, Yugen
Li, Xiukai
Abstract
There is provided a method of converting polypropylene (PP) to oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures, the method comprising: oxidizing a PP containing source in the presence of a catalyst to obtain OPP; dissolving the OPP in a first liquid to obtain a dissolved solution of OPP; and precipitating OPP micro-sized particles having hierarchical nanostructures from the dissolved solution of OPP by adding the dissolved solution of OPP to a second liquid. Also provided is a material comprising oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Tam, Wai Leong
Pathak, Elina
Abstract
The invention relates generally to field of cancer biology. Provided herein are methods of inhibiting epithelial- mesenchymal transition (EMT) and for inhibiting or preventing metastasis in a cancer cell, the methods comprising contacting the cancer cell with an effective amount of a histone deacetylase 6 (HDAC6) inhibitor and a glycogen synthase kinase-3[3 (GSK30) inhibitor. Methods of screening for an inhibitor of EMT comprising a reporter cell line, which comprises a ZEB1 inducible construct, and an epithelial gene reporter construct are also provided herein.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Yao, Kui
Mohamed Yousry, Yasmin
Chen, Shu Ting
Lim, Poh Chong
Abstract
A sound absorption material and a method (10) of fabricating a sound absorption material are provided. The method (10) includes preparing (12) a first precursor solution or suspension of one of a first triboelectric material and a second triboelectric material; and forming (16) a porous structure by using the first precursor solution or suspension in one of a templating technique with a second precursor solution or suspension of the other one of the first and second triboelectric material, an immersion technique with the other one of the first and second triboelectric materials, and an electrospinning technique with the other one of the first and second triboelectric materials. The porous structure includes a hybrid composite of the first triboelectric material having a first charge affinity and the second triboelectric material having a second charge affinity, wherein the first charge affinity is greater than the second charge affinity.
Agency for Science, Technology and Research (Singapore)
Inventor
Sampei, Zenjiro
Koo, Xing'Er Christine
Fink, Katja
Zuest, Roland
Abstract
The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Baranikov, Anton
Khaidarov, Egor
Lassalle, Emmanuel
Paniagua Dominguez, Ramon Jose
Kuznetsov, Arseniy
Abstract
Various embodiments may relate to an optical system. The optical system may include a plurality of color filters, a first color filter of the plurality of color filters configured to select light of different wavelength ranges representing different color channels. The optical system may also include a plurality of metalenses, each of the plurality of metalenses associated with a respective color channel of the plurality of color channels. Each of the plurality of metalenses may have a focal length, the plurality of metalenses having equal focal lengths such that the different color channels are combined on a common focal plane to form a multi-color image. Each of the plurality of metalenses may include a plurality of nanostructures, have a (FOV) field of view of more than 30 degrees, and a desired working spectral bandwidth dependent on an extended depth of focus, a central wavelength of the associated color channel, and the focal length at the central wavelength.
Agency for Science, Technology and Research (Singapore)
Inventor
Fong, Wey Jia
Choo, Boon Hwa
Ding, Mei Yee Vanessa
Chin, Chui Ping
Abstract
The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Adriani, Giulia
Pavesi, Andrea
Abstract
There is provided a device for vascularising a cell aggregate, the device comprising: a matrix region configured to contain a gel-like matrix and cells that form a vasculature network within th ematrix region. The matrix region having at least one opening for positioning the cell aggregate therein based on a desired three-dimensional spatial location; and one or more fluidic regions configured to contain a supporting fluid that is capable of supporting vascularisation of the cell aggregate, the one or more fluidic regions being in fluid communication with the matrix region, wherein a flow passage from the one or more fluidic regions to a gel-like matrix disposed in the matrix region is configured to allow three-dimensional vascularisation around the cell aggregate and perfusion of the vasculature once formed. There is also provided a chip comprising a plurality of the device as disclosed herein and a method for vascularising a cell aggregate.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Zhu, Yao
Liu, Chen
Wang, Nan
Abstract
Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.
H10N 30/067 - Forming single-layered electrodes of multilayered piezoelectric or electrostrictive parts
H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
H03H 9/17 - Constructional features of resonators consisting of piezoelectric or electrostrictive material having a single resonator
H10N 30/07 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base
H03H 3/02 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of piezoelectric or electrostrictive resonators or networks
39.
NEURAL PROCESSING CORE FOR A NEURAL NETWORK AND METHOD OF OPERATING THEREOF
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Jiang, Wenyu
Chee, Piew Yoong
Xiao, Rui
Abstract
A neural processing core for a neural network is provided, which includes: a synaptic memory array including synaptic memory cells arranged in a plurality of memory cell rows and columns; a plurality of first input activation lines connected to the plurality of memory cell rows, respectively, of the synaptic memory array and configured to receive a plurality of first input activation signals, respectively, to the plurality of memory cell rows; and a plurality of first sensing lines connected to the plurality of memory cell columns, respectively, of the synaptic memory array and configured to output a plurality of first analog electrical signals, respectively, from the plurality of memory cell columns. In particular, the neural processing core is configured to control the synaptic memory cells of the synaptic memory array in a column-wise manner. There is also provided a corresponding method of operating the neural processing core for a neural network.
G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron
40.
Expression System for Protein Production and Screening
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
ALBATROZ THERAPEUTICS PTE. LTD. (Singapore)
RICHARD IAN CLEGG (United Kingdom)
Inventor
Bard, Frederic
Wang, Cheng-I
Chia, Zhi Hui Joanne
Ngoh, Eve
Le Guezennec, Xavier
Min, Tham Keit
Nguyen, Anh Tuan
Bennion, Rebecca
Abstract
Antigen binding molecules capable of binding to calnexin (CNX) are disclosed herein. Also disclosed are chimeric antigen receptors, antibody-drug conjugates, and compositions comprising such antigen binding molecules, as well as nucleic acids, vectors and cells. Uses and methods involving antigen binding molecules capable of binding to calnexin (CNX) are also disclosed.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wang, Zeng
Teng, Jinghua
Abstract
Various embodiments may relate to an optical system. The optical system may include a laser source for emitting one or more laser beams. The optical system may also include a metalens, a first stage mounting the metalens, a first motor configured to move the first stage, a second stage for holding a sample, and a second motor configured to move the second stage. The optical system may include an objective, a third stage configured to hold the objective, and a third motor configured to move the third stage. The optical system may also include a detector and a screen including or defining a pinhole, the screen arranged between the objective and the detector. The optical system may also include a processor in electrical communication with the first motor, the second motor and the third motor.
B82Y 40/00 - Manufacture or treatment of nanostructures
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Olivo, Malini
Choolani, Mahesh Arjandas
Wang, Yusong
Perumal, Jayakumar
Dev, Kapil
Balasundaram, Ghayathri
Moothanchery, Mohesh
Unnimadhava Kurup Soudamini Amma, Dinish
Abstract
A method of identifying one or more bacteria from a sample, wherein the one or more bacteria is suspected to be present in the sample, is provided. The method may include providing an aqueous suspension comprising a bacteria-SERS nanoparticle complex, wherein the bacteria-SERS nanoparticle complex comprises (i) a SERS nanoparticle and (ii) the one or more bacteria suspected to be present in the sample; depositing the aqueous suspension comprising the bacteria-SERS nanoparticle complex on a substrate having structures coated with a SERS-active material to dispose the bacteria-SERS nanoparticle complex on the substrate; irradiating the bacteria-SERS nanoparticle complex disposed on the substrate with laser to generate one or more SERS signals; having a SERS-spectroscopic module operable to render one or more SERS spectral data corresponding to the one or more SERS signals; and having a process module operable to identify the presence or absence of the one or more bacteria from the one or more SERS spectral data.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Zhu, Di
Chai, Kevin Tshun Chuan
Mani, Aarthy
Do, Anh Tuan
Abstract
This document describes a spatial light modulator that comprises a pixel array having a plurality of pixels whereby each pixel in this array is communicatively coupled to a digital pixel circuit which are in turn all coupled to a bit-plane control circuit. The bit-plane control circuit is configured to generate, using a Pulse Code Modulation (PCM) algorithm, bit-plane signals that are used to control the sample and hold functions performed by each of the digital pixel circuits so that the pixel array may carry out its scanning function accurately and in a power efficient manner.
G02F 1/1368 - Active matrix addressed cells in which the switching element is a three-electrode device
G09G 3/36 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix by control of light from an independent source using liquid crystals
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
THE JIKEI UNIVERSITY (Japan)
Inventor
Ow, Jin Rong
Imagawa, Eri
Tabaglio, Tommaso
Oishi, Kimihiko
Wee, Keng Boon, Dave
Abstract
The present invention relates to splice-switching oligonucleotides (SSOs) capable of altering the slicing of a pre-mRNA encoding a variant of the SLC25A13 gene, as well as the use of the same SSOs for treating citrin deficiency. In an embodiment, a SSO that binds to a site within a target region present on a pre-mRNA transcript of the SLC25A13 gene, wherein the binding of the SSO induces the exclusion of SLC25A13-PE5 from a mature mRNA transcript of the SLC25A13 gene. In another embodiment, the target region having at least 95% sequence identity to SEQ ID NO: 28.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NANYANG TECHNOLOGICAL UNIVERSITY (Singapore)
Inventor
Wong, Ten It
Zhou, Xiao Dong
Zhao, Ke
Ge, Liya
Lisak, Grzegorz
Abstract
An analyser (10, 100) for pollutant detection and a computer-implemented method (200) for pollutant detection are provided. The analyser (10, 100) includes one 5 or more electrochemical detection units (12, 102), one or more processors (14), a non-transitory computer-readable memory (16) and a display (18). Each of the one or more electrochemical detection units (12, 102) is configured to receive a control voltage signal according to a pollutant-specific detection protocol and output a measured current signal based on a measured electrical current from an electrode chip (20). The non-transitory 0 computer-readable memory (16) stores a detection protocol for each of a plurality of pollutants, a characterisation curve for each of the pollutants and computer program instructions executable by the one or more processors (14) to perform operations for pollutant detection, the operations comprising: identifying a current peak in the measured current signal; determining a peak intensity corresponding to the identified current peak; 5 and determining a concentration of a selected pollutant from the characterisation curve of the selected pollutant based on the determined peak intensity. The display (18) is configured to display the concentration of the selected pollutant.
NATIONAL SKIN CENTRE (SINGAPORE) PTE LTD (Singapore)
NANYANG TECHNOLOGICAL UNIVERSITY (Singapore)
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Thng, Steven Tien Guan
Chuah, Sai Yee
Xie, Jun
Kong, Wai-Kin Adams
Lin, Li
Abstract
A system for classification of basal cell carcinoma (BCC) and a method of classifying basal cell carcinoma (BCC) may be provided, the system comprising a processing module configured to receive an input image sequence comprising a plurality of images; and a prediction module coupled to the processing module, the prediction module comprising a hierarchical ensemble structure of a plurality of classification models; wherein the processing module is configured to process each image as a whole image to obtain a plurality of first sub-sections and to further process each first sub-section to obtain a corresponding plurality of second sub-sections; further wherein the processing module is configured to transmit the each first sub-section to a first classification model of the prediction module trained to process the first sub-sections and to transmit each of the corresponding plurality of second sub- sections to a second classification model of the prediction module trained to process the second sub-sections, further wherein the prediction module is configured to determine a probability of BCC of the each image of the input image sequence based on a plurality of respective block prediction results corresponding to the first sub-sections of the each image; and further wherein the prediction module is configured to determine a BCC classification of the input image sequence based on the determined probability of BCC of each image of the input image sequence.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
49.
BIOACTIVE POLYETHYLENE COPOLYMER, POLYETHYLENE MACROMOLECULE AND RELATED METHODS THEREOF
Agency for Science, Technology and Research (Singapore)
Mitsui Chemicals, Inc. (Japan)
Inventor
Teo, Peili
Makio, Haruyuki
Guo, Jiayi
Park, Eun Ju
Teo, Yew Chin
Abstract
There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
Agency for Science, Technology and Research (Singapore)
Inventor
Khin, Phone May
Low, Jin Huat
Chen, Chao-Yu
Yeow, Chen Hua
Zhang, Ying
Abstract
A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.
Agency for Science, Technology and Research (Singapore)
Inventor
Teo, Peili
Guo, Jiayi
Teo, Yew Chin
Park, Eun Ju
Abstract
There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.
There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
52.
BICYCLIC COMPOUNDS AS KINASE MODULATORS, METHODS AND USES THEREOF
Agency for Science, Technology and Research (Singapore)
Inventor
Adsool, Vikrant Arun
Abstract
The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.
C07D 215/233 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Tay, Zirui, Matthew
Lin, Weikang, Nicholas
Cheow, Lih Feng
Chen, Chia-Hung
Rénia, Laurent Claude Stéphane
Ng, Fong Poh, Lisa
Abstract
The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; iincubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
SINGAPORE HEALTH SERVICES PTE LTD (Singapore)
Inventor
Shanmugam, Raghuvaran
Tergaonkar, Vinay Bhimrao Krishna
Tan, Iain Bee Huat
Macalinao, Dominique Camat
Chong, Qingqing Dawn
Abstract
The disclosure relates to methods of treatment and methods of identifying subjects for such treatment based on levels of pirin and/or iron in samples from the subject. In one embodiment, the subject is suffering from cancer, such as colorectal cancer, hemochromatosis or anaemia. In one embodiment, the treatment includes administration of iron chelator or pirin inhibitor.
Agency for Science, Technology and Research (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Chin, Zheng Yang
Zhang, Haihong
Guan, Cuntai
Wang, Chuan Chu
Lee, Tih Shih
Abstract
Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Tay, Richie Pei Kun
Ow, Siak Wei
Abstract
The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.
C07K 14/335 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Chen, Chao
Li, Xu
Wang, Suxi
Zhang, Xikui
Wong, Siew Yee
Abstract
A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Yang, Yuansheng
Cool, Simon Mckenzie
Loh, Han Ping
Smith, Raymond Alexander Alfred
Abstract
There is provided a nucleic acid construct comprising one or more internal ribosome entry site (IRES), one or more gene of interest, and a pair of site-specific recombinase, wherein the gene of interest is a heparan sulfate variant gene, a heparan sulfate modification enzyme gene, and/or a heparan sulfate scaffold protein gene. Also disclosed are a vector, a host cell and / or cell line, recombinant heparan sulfates, methods, kits for use thereof.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Kan Eiichiro
Chen Yi Hsin
Lianto Kartikasaridian
Kawashima Tadaomi
Chow Yvonne
Hermansen Christian
Naulchan Khongsay
Abstract
The present invention relates to a koji mold fermentation product of a cereal-derived material which has an arabinan concentration of 5 mg/g or less. The present invention also relates to a method for producing a koji mold fermentation product of a cereal-derived material, said method comprising treating the cereal-derived material with an arabinase and a cellulase and fermenting the thus treated material using koji mold.
C12P 1/02 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymes; General processes for the preparation of compounds or compositions by using microorganisms or enzymes by using fungi
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Lim, Yee Hwee
Ang, Ee Lui
Wong, Fong Tian
Peh, Guangrong
Tay, Song Buck
Abstract
The present disclosure concerns enzymes and their uses in biocatalytic halogenation of pyrrolic heterocycles thereof. The method of halogenating a 2', 3' and/or 5' substituted N-heteroaryl or a derivative thereof comprises contacting the N-heteroaryl or derivative thereof with a halogen and a flavin-dependent halogenase under co-enzyme regeneration conditions in order for the halogen to be substituted at a 4' position on the N-heteroaryl or derivative thereof.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Chen, Weiguo
Lee, Lennon Yao Ting
Abstract
Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Chakraborty, Smarajit
Ravikumar, Vikashini
Sugii, Shigeki
Abstract
The present disclosure provides an anti-bacterial peptide comprising ENOS or SPARCL1, or partial sequences thereof. The present disclosure also provides a conditioned cell culture media comprising the anti-bacterial peptide, wherein the conditioned cell culture media is made by culturing adipose-derived mesenchymal stem cells. The technology also relates to a method of treating infections using the peptides.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
Agency for Science, Technology and Research (Singapore)
Inventor
Gan, Bong Hwa
Inoue, Masafumi
Diermayr, Veronica
Abstract
The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
65.
A FAMILY OF THERMOGELLING CATIONIC COPOLYMERS CONTAINING POLYETHYLENIMINE AND POLYPROPYLENE GLYCOL
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Loh, Xian Jun
Lim, Yuan Chong Jason
Lin, Qianyu
Abstract
Described herein are compositions containing branched polyethylenimine and polypropylene glycol covalently bonded to the branched polyethyleneimine, where a molar ratio of the propylene glycol to the branched polyethylenimine is more than 3.35:1, and the polypropylene glycol is hydrophobic. The compositions may be used as a hydrogel and changes between a solution phase and a gel phase by changes in pH or temperature.
C08G 71/00 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a ureide or urethane link, otherwise than from isocyanate radicals
C08L 75/12 - Polyurethanes from compounds containing nitrogen and active hydrogen, the nitrogen atom not being part of an isocyanate group
C08G 73/04 - Polyamines derived from alkyleneimines
C08G 65/02 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
66.
APPARATUS FOR OUTER WALL FOCUSING FOR HIGH VOLUME FRACTION PARTICLE MICROFILTRATION AND METHOD FOR MANUFACTURE THEREOF
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Goh, Shireen
Tan, Shan Mei
Abstract
An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Aw, Shiying, Sherry
Lim, Yu Theng, Mandy
Teo, Shi Jie
Abstract
There is provided a ribozyme comprising: a) one or more catalytic domains capable of switching between an active state and an inactive state; b) one or more releasable RNA segments, wherein each of said releasable RNA segments is flanked by two ribozyme cleavage sites, wherein cleavage at each cleavage site is catalysed by at least one of the one or more catalytic domains in an active state; c) one or more trigger-binding domains, each of which is for the binding of a trigger nucleic acid molecule; wherein each of the one or more catalytic domains is linked to one of the one or more trigger-binding domains; wherein the catalytic domain is in an inactive state when the trigger-binding domain linked to said catalytic domain is not bound by the trigger nucleic acid molecule, and wherein the catalytic domain is in an active state when the trigger-binding domain linked to said catalytic domain is bound by the trigger nucleic acid molecule; and wherein when both cleavage sites flanking a releasable RNA segment are cleaved when catalysed by the one or more catalytic domains, the one or more releasable RNA segment is released from the ribozyme. Also disclosed are methods of detecting presence of a trigger nucleic acid molecule in a sample, methods of detecting presence of a sequence or mutation of interest on an nucleic acid of interest in a sample, and kits comprising the ribozymes thereof.
Agency for Science, Technology and Research (Singapore)
Inventor
Phoon, Pui Yeu
Abstract
The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.
A23D 9/007 - Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Gruber, Gerhard
Bates, Roderick Wayland
Ng, Shuyi Pearly
Abstract
The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.
The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61P 31/06 - Antibacterial agents for tuberculosis
70.
Neurosynaptic Processing Core with Spike Time Dependent Plasticity (STDP) Learning For a Spiking Neural Network
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wong, Ming Ming
Shrestha, Sumit Bam
Paramasivam, Vishnu
Mani, Aarthy
Jiang, Wenyu
Do, Anh Tuan
Abstract
There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.
Agency for Science, Technology and Research (Singapore)
Inventor
Beh, Cyrus Weijie
Abstract
A closure for a sample tube comprises a reaction vessel. The reaction vessel comprises: at least one microfluidic mixing channel having an inlet and an outlet; at least one reaction chamber in fluid communication with the inlet and the outlet; an inlet chamber proximate the inlet of the at least one microfluidic mixing channel for introducing a portion of a sample solution from the sample tube into the at least one reaction chamber under hydrostatic pressure; and a diffusion-control feature for limiting egress of fluid from the outlet such that the portion of the sample solution introduced to the at least one reaction chamber is partitioned from the rest of the sample solution.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wu, Lele
Tergaonkar, Vinay
Abstract
The present invention relates to a method comprising the detection of LOC105375914 RNA in a glioma sample obtained from a subject, wherein an elevated level of LOC105375914 RNA as compared to a reference indicates that the subject has a high grade glioma, has a likelihood of resistance to chemotherapy, has a likelihood of recurrence, and/or is likely to have a poor prognosis. The present invention also relates to a method of treating a glioma expressing LOC105375914 RNA in a subject by administering an inhibitor of the LOC-DEAH-box helicase 15 (DHX15) complex to the subject.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Park, Eun Ju
Teo, Peili
Teo, Yew Chin
Abstract
There is provided a regenerative material for skin, bone and/or cartilage tissue regeneration, the material comprising, a hyaluronic acid-based synthetic copolymer having one or more repeating units represented by general formula (Vlll-a). Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, hyaluronic acid-based macromolecule, and a method of preparing said hyaluronic acid-based macromolecule.
C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers
A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
Agency for Science, Technology and Research (Singapore)
Inventor
Sriram, Sandhya
Sugii, Shigeki
Chang, Young Tae
Kang, Nam-Young
Abstract
Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.
Agency for Science, Technology and Research (Singapore)
Inventor
Dong, Xuecheng
Saw, Eng Toon
Ang, Kun Liang
He, Wei
Abstract
A method of producing a silicalite membrane, which includes heating an aqueous solution that includes a dopant precursor and structure-directing template agents to form silicalite seeds incorporated with a dopant, depositing a buffer layer on a ceramic substrate prior to depositing the silicalite seeds on the buffer layer, contacting the ceramic substrate with a solution including the silicalite seeds to form a silicalite layer from the silicalite seeds on the ceramic substrate, and removing the structure-directing template agents to form the silicalite membrane, where the silicalite layer includes silicalite crystals incorporated with a dopant and each of the silicalite crystals has a hollow structure which forms the pores of the silicalite layer. The silicalite membrane includes a ceramic substrate having a buffer layer formed thereon, and a silicalite layer formed on the buffer layer, where the silicalite layer includes silicalite crystals incorporated with a dopant.
Agency For Science, Technology And Research (Singapore)
Inventor
Park, Nathaniel H.
Hedrick, James L.
Piunova, Victoria A.
Jones, Gavin
Yang, Yi Yan
Tan, Pang Kern Jeremy
Yang, Chuan
Alexander, Cherylette Anne
Abstract
Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
CLEGG, Richard Ian (United Kingdom)
Inventor
Teo, Pei Yun
Low, Lionel Jianrong
Jung, Youngrock
Abstract
Immune cells comprising modification to increase the expression or activity of SERPINB9 are disclosed. Also disclosed are compositions comprising such cells and methods of using such cells and compositions.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Ooi, Yau Yen
Abstract
Various embodiments may relate to a fluid extraction apparatus. The fluid extraction apparatus may include a syringe holder configured to hold one or more syringes, and a first linear actuator configured to move the syringe holder into a position for loading of a syringe of the one or more syringes. The fluid extraction apparatus may also include a stand, a rotary platform on the stand, and a vial holder on the rotary platform. The fluid extraction apparatus may also include a cap gripper on the rotary platform, a rotary actuator configured to rotate the rotary platform between a first configuration and a second configuration, a second linear actuator configured to actuate a plunger of the syringe such that the syringe extracts at least the portion of the fluid, and a controller configured to control the first linear actuator, the second linear actuator, and the rotary actuator.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
79.
OPTICAL SYSTEM, METHODS OF FORMING AND OPERATING THE SAME
Agency for Science, Technology and Research (Singapore)
Inventor
Dev, Kapil
Zhang, Ruochong
Wong, Chi Lok
Zhang, Shuyan
Unnimadhava Kurup Soudamini Amma, Dinish
Olivo, Malini Carolene Devapiriyai
Abstract
An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
G01N 21/84 - Systems specially adapted for particular applications
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
80.
ELECTRO-OPTIC MODULATOR AND METHOD OF FORMING THE SAME
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Zhu, Shiyang
Zhong, Qize
Abstract
Various embodiments may relate to an electro-optic modulator. The electro-optic modulator may include a waveguide configured to carry optical light along a longitudinal length of the waveguide. The electro-optic modulator may also include a first electrically conductive sub-wavelength grating on a first side of the waveguide, the first electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may further include a second electrically conductive sub-wavelength grating on a second side of the waveguide opposite the first side, the second electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may be configured to modulate the optical light upon application of a potential difference between the first electrically conductive sub-wavelength grating and the second electrically conductive sub-wavelength grating based on Pockels effect.
G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour by interference
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Liang, Kun
Leong, Kit Mun Cheryl
Abstract
The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.
A61B 10/02 - Instruments for taking cell samples or for biopsy
B29C 33/42 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
B33Y 80/00 - Products made by additive manufacturing
82.
CRISPR-BASED METHODS FOR THE DETECTION OF NUCLEIC ACIDS IN A SAMPLE
Agency for Science, Technology and Research (Singapore)
Inventor
Tan, Meng How
Ooi, Kean Hean
Tay, Jie Wen Douglas
Teo, Seok Yee
Abstract
The present invention is in the field of molecular diagnostics and is directed to the detection of target nucleic acids in a sample using a modified CRISPR-Dx system, typically with prior amplification of the target. The modified CRISPR-Dx system comprising an engineered E174R/S542R/K548R variant of AsCas12a, wherein when get activated indiscriminately cleaves at least one detection reagent to generate signal. In one embodiment, the target nucleic acid is SARS-CoV-2 RNA.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
83.
MEDICAL IMAGE PROCESSING METHODS AND SYSTEMS FOR ANALYSIS OF CORONARY ARTERY STENOSES
Agency For Science, Technology And Research (Singapore)
Inventor
Zhong, Liang
Huang, Weimin
Zhang, Junmei
Chandola, Gaurav
Lim, Soo Teik
Tan, Ru San
Tan, Swee Yaw
Abstract
Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.
G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
G06T 7/64 - Analysis of geometric attributes of convexity or concavity
G06T 7/66 - Analysis of geometric attributes of image moments or centre of gravity
G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
Agency for Science, Technology and Research (Singapore)
NIPO International Pte. Ltd. (Singapore)
Inventor
Thoniyot, Praveen
Dong, Sam Siming
Eng, Yi Jie
Tan, Steve
Khoo, Amanda
Abstract
There is provided a composition comprising a slurry of capsules, the capsules having shells comprising silica and said shells encapsulating phase change materials (PCM); and a cementitious binder. There is also provided a method for preparing said composition.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL SKIN CENTRE (SINGAPORE) PTE LTD (Singapore)
Inventor
Tey, Hong Liang
Tan, Siyun Lucinda
Ong, Ee Ping
Ruchir, Srivastava
Abstract
Methods and systems for facilitating analysis of a skin condition are provided. The methods apply a deep neural network (DNN) to a digital skin image to identify or prepare a digital lesion skin image for further processing. Further processing can involve calculating an asymmetry (A) score based on a feature vector produced by combining feature vectors derived from the digital lesion skin image, calculating a border score based on the regularity of a lesion or skin condition, calculating a colour score based on colours detected in the digital lesion skin image, calculating a dermatoscopic score based on a presence of dermatoscopic features or structures in a digital skin lesion image, and finally calculating a final score based on the asymmetry, border, colour and dermatoscopic scores, the final score indicating a likelihood of the skin condition.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
G06V 10/28 - Quantising the image, e.g. histogram thresholding for discrimination between background and foreground patterns
G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
G06V 10/56 - Extraction of image or video features relating to colour
86.
COMPOSITE COATING MATERIAL FOR PASSIVE VIBRATION DAMPING
Agency for Science, Technology and Research (Singapore)
Inventor
Yao, Kui
Liew, Siao Li
Chen, Shuting
Tan, Sze Yu
Salloum, Rogério
Yan, Hong
Zhang, Lei
Lai, Szu Cheng
Abstract
A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).
C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
C09D 137/00 - Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen; Coating compositions based on derivatives of such polymers
Agency for Science, Technology and Research (Singapore)
Inventor
Jana, Satyasankar
Seayad, Jayasree
Seayad, Abdul Majeed
Choong, Ping Sen
Abstract
There is provided a polymer or derivative thereof comprising a plurality of active amine groups in the backbone, wherein the polymer is a reaction product of a reaction between one or more bis-carbonates and one or more amine compounds having at least two terminal amino groups. Also provided are use of the polymer or derivative thereof and a method of preparing the polymer or derivative thereof.
C10M 149/14 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds a condensation reaction being involved
A01N 47/12 - Carbamic acid derivatives, i.e. containing the group —O—CO—N; Thio-analogues thereof containing a —O—CO—N group, or a thio-analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof
B01D 53/78 - Liquid phase processes with gas-liquid contact
B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Hong, Jing Han
Tan, Jing
Teh, Bin Tean
Abstract
Disclosed herein a method of treating a BAP1 -related tumour in a subject, the method comprising determining whether BAP1 in the sample is functional or non-functional, and administering to the subject a therapeutically effective amount of a PARP inhibitor and a LSD1 inhibitor if BAP1 in the sample is non-functional. Also disclosed herein is a method screening and identifying an anti-proliferative compound, the method comprising obtaining a population of BAP1-deficient cells, treating said BAP1 -deficient cell population with the anti-proliferative compound, and determining a change in proliferative activity of the population of BAP1 -deficient cells compared to a population of cells producing functional BAP1 protein.
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/502 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Wan, Yue
Liao, Kuo Chieh
Gao, Xiang
Abstract
The invention relates to generally to the field of molecular biology. In particular, the invention is directed to a vector for generating a circular RNA. Methods for generating circular RNA from a precursor RNA transcribed from the vector are also provided herein.
C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Singapore Health Services Pte Ltd (Singapore)
National University Hospital (Singapore) Pte Ltd (Singapore)
Tan Tock Seng Hospital Pte Ltd (Singapore)
MiRXES Lab Pte. Ltd. (Singapore)
Inventor
Lee-Lim, Siew Gek
Zou, Ruiyang
Zhou, Lihan
Cheng, He
Hartman, Bo Anders Mikael
Too, Heng-Phon
Abstract
This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
PANTHERA LABS PTE. LTD. (Singapore)
Inventor
Teo, Kee Keong Adrian
Tan, Lay Shuen
Chen, Juin Ting
Lim, Kah Meng
Abstract
The present invention relates generally to the field of pluripotent stem cell. In particular, the invention relates to a serum- free method for differentiating pluripotent stem cells into multipotent mesenchymal stem cells (MSCs). The invention also relates to serum-free composition for differentiating pluripotent stem cells into multipotent MSCs, the composition comprising Dulbecco's Modified Eagle Medium (DMEM), KnockOut™ serum (KOSR), and GlutaMAX.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Li, Jun
Li, Zhengguo
Wan, Kong Wah
Chan, Chee Leong, Raymond
Yau, Wei Yun
Abstract
A method and system for navigating a robot 100 in a designated environment are provided herein. In an embodiment, the method comprises: selectively identifying reference features from a scale plan of the designated environment; generating a topometric map 178 of the designated environment, the topometric map 178 being associated with the identified reference features; generating an initial navigation path 176 of a local region 174 from the topometric map 178; as the robot 100 navigates along the initial navigation path 176 of the local region 174, detecting on-site reference features of the local region 174 that correspond to the identified reference features of the scale plan; and updating the topometric map 178 based on the correspondence to generate a regional path plan 188 to guide the robot's direction in the local region 174.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Chan, Chee Leong Raymond
Li, Jun
Chan, Jian Le
Li, Zhengguo
Wan, Kong Wah
Abstract
Method and system for localising a robot 100 using a scale plan of a designated environment are provided herein. In an embodiment, the method comprises: identifying reference features from the scale plan 136; generating a predicted pose 156 of the robot's current location on the scale plan 136 based on the identified reference features; scanning on-site reference features 186 of the current location; generating a map 158 for the current location to localise the robot 100, based on the scanned on-site reference features 186 of the current location and last N frames of historical scans of previous on-site reference features 186 of a plurality of locations in the designated environment that the robot traversed through before reaching the current location; the last N frames being fewer than total frames of the historical scans of the previous on-site reference features 186.
Agency for Science, Technology and Research (Singapore)
Inventor
Lee, Lennon Yao Ting
Abstract
A chemical sensor that includes a first semiconductor substrate. The chemical sensor may also include a second semiconductor substrate. The chemical sensor may further include one or more metal layers between the first semiconductor substrate and the second semiconductor substrate such that the first and second semiconductor substrates and the one or more metal layers form a cell including a cavity, the cavity having a depth of any value equal to or less than 100 μm. The chemical sensor may also include an optical source. The chemical sensor may additionally include an optical detector such that light emitted by the optical source passes through the cell to the optical detector. The first and second semiconductor substrates and the one or more metal layers may also define at least one inlet for fluid to flow into the cavity and at least one outlet for fluid to flow out of the cavity.
H01L 25/16 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices the devices being of types provided for in two or more different main groups of groups , or in a single subclass of , , e.g. forming hybrid circuits
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Chen, Tao Yi David
Hee, Jia Yun
Ho, Shihan Bryan
Mohan, Preeti
Abstract
There is provided an implant configured to be deployed in an eye by a deployer tool to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, the implant comprising, an elongate member having a proximal segment configured to be disposed in the posterior chamber of the eye and a distal segment configured to be disposed in the suprachoroidal space of the eye, wherein the elongate member is configured to maintain a bent configuration that substantially complies with anatomical curvatures of the posterior chamber and the suprachoroidal space, when deployed in the eye. There is also provided a deployer tool for inserting an implant as disclosed herein into an eye to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, and a system for facilitating the conduction of fluid from a posterior chamber to a suprachoroidal space of an eye.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Ma, Yugang
Jin, Bo
Sun, Sumei
Zeng, Yonghong
Zhong, Zhigang
Abstract
A method for tracking one or more living objects using at least one processor is provided. The method includes: receiving, via a plurality of receiving antennas, signals transmitted from a plurality of transmitting antennas; identifying a location of each of the one or more living objects with respect to a discrete time based on the signals received in a number of a sampling periods; determining a movement of each of the one or more living objects based on the identified location; determining one or more vital signs of each of the one or more living objects based on the movement of each of the one or more living objects; and tracking collectively the location and the one or more vital signs of each of the one or more living objects.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
G01S 13/36 - Systems for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Leong, Jiacheng, Andrew
Adiwahono, Albertus, Hendrawan
You, Yangwei
Chuah, Meng Yee
Chen, Tai Pang
Chan, Jian Le
Chan, Chee Leong, Raymond
Ng, Kam Pheng
Wan, Kong Wah
Yau, Wei Yun
Abstract
A method and system for navigating a robot 100 are provided herein. In an embodiment, the method comprises: detecting on-site reference features of the robot's location when the robot is traversing in an environment; identifying objects of interest 180 from the detected on-site reference features; deriving a semantic data for each object of interest 180 from the on-site reference features; generating a semantic cost map 166 based on the semantic data of the objects of interest 180, the semantic cost map 166 representing cost of traversing in the environment; and navigating the robot 100 based on the semantic cost map 166.
G05D 1/02 - Control of position or course in two dimensions
G01C 21/00 - Navigation; Navigational instruments not provided for in groups
G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestrians; Recognition of traffic objects, e.g. traffic signs, traffic lights or roads
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Grűber, Gerhard
Bates, Roderick Wayland
Ng, Shuyi Pearly
Abstract
Disclosed herein is a combination that includes a F1F0-ATP synthase inhibitor or a pharmaceutically acceptable salt or solvate thereof that selectively binds to the F1 domain of the F1F0-ATP synthase in combination with one or more of the compounds selected from: (a) an NADH dehydrogenase inhibitor or a pharmaceutically acceptable salt or solvate thereof; (b) a cytochrome-bcc:aa3 inhibitor or a pharmaceutically acceptable salt or solvate thereof; and (c) a F1F0-ATP synthase inhibitor or a pharmaceutically acceptable salt or solvate thereof that selectively binds to the F0 domain of the F1F0-ATP synthase.
A61P 31/06 - Antibacterial agents for tuberculosis
A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/451 - Non-condensed piperidines, e.g. piperocaine having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
99.
A SYSTEM AND METHOD OF DETECTING A DIRECTION OF ARRIVAL OF ONE OR MORE TARGET SIGNALS USING AN ANTENNA ARRAY
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
Inventor
Tang, Xinyi
Qing, Xianming
Abstract
There is provided a system and method of detecting a direction of arrival of one or more target signals using an antenna array, the method comprising, i) generating a map representing a ratio of a co-polarization (Co-pol) pattern received by the first beam to a cross- polarization (X-pol) pattern received by the second beam; ii) obtaining Co-pol and X-pol signal strengths of the one or more target signals received by the first and second beams in step (i); iii) obtaining the Co-pol to X-pol ratio of each of the one or more target signals; iv) normalizing the generated map; v) normalizing the Co-pol to X-pol ratios of the one or more target signals; and vi) for each target signal: finding area(s), within the normalized generated map, which substantially match the normalized Co-pol to X-pol ratio of the target signal; and identifying said area(s) of the normalized generated map as potential direction(s) of arrival of the target signal.
G01S 3/04 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using radio waves - Details
H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
Agency for Science, Technology and Research (Singapore)
Nanyang Technological University (Singapore)
Inventor
Becker, David
Chin, Jiah Shin
Madden, Leigh
Tan, Li Ling Mandy
Abstract
The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine