Abstract

The present invention relates to methods of treating diseases or conditions associated with abnormal levels of lamin B1 protein. Disclosed herein are methods of treating pathologies of lamin B1 accumulation, such as Adult-onset Autosomal Dominant Leukodystrophy (ADLD), using farnesyltransferase inhibitors (FTIs), such as FTI-277, lonafarnib or Tipifarnib.

IPC Classes  ?

• A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

There is provided a method of preparing a meat analogue. In one embodiment, the method comprises the steps of : (a) blending a mixture comprising wheat gluten and a protein source at a weight ratio in the range of 50:50 to 70:30; (b) heating the mixture of the blending step (a) in the presence of water at a temperature in the range of 100 °C to 140 °C to form a dough; and (c) cutting the dough of the heating step (b) to form the meat analogue. There is also provided a meat analogue prepared by the method.

IPC Classes  ?

• A23J 3/18 - Vegetable proteins from wheat

Abstract

The invention relates to a method of separating protein fractions from a protein sample comprising the steps of dispersing the protein sample in a deep eutectic solvent to form a dispersion, treating the dispersion with elevated temperature to form a first protein fraction and a supernatant, and followed by treating the supernatant with elevated pressure or precipitating via pH adjustment to form a second protein fraction. The method may also be carried out by the steps of treating the dispersion at an elevated pressure to form the second protein fraction and a supernatant, and followed by treating the supernatant at an elevated temperature or precipitating via pH adjustment to form the first protein fraction. The invention further relates to protein fractions obtained from the method.

IPC Classes  ?

• C07K 1/14 - Extraction; Separation; Purification
• C07K 1/02 - General processes for the preparation of peptides in solution

Abstract

There is provided a method of obtaining at least one protein fraction from a protein sample. There is also provided a protein fraction obtained from the method as provided herein.

IPC Classes  ?

• A23J 3/14 - Vegetable proteins
• A23J 1/14 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from press-cake or oil-bearing seeds
• A23L 33/185 - Vegetable proteins

Abstract

A method and apparatus for penetrating a cell with a particle are described. The method includes providing a layer of cells at or proximal to a bottom end of a vessel; adding a plurality of particles to the vessel; and applying a force to move the plurality of particles towards the bottom end of the vessel to cause at least some of the plurality of particles to penetrate at least some of the cells. The apparatus includes a vessel having a bottom end for containing a layer of cells at the bottom end; and a force exerting component configured to apply a force to move a plurality of magnetic particles within the vessel towards the bottom end of the vessel to penetrate at least some of the cells with at least some of the plurality of magnetic particles.

IPC Classes  ?

• A61K 49/06 - Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
• A61B 5/0515 - Magnetic particle imaging
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The present disclosure relates to methods of generating induced pluripotent stem cell (iPSC)-derived Kupffer cells (iKCs), where the method comprises contacting iPSC-derived macrophages with iPSC-derived hepatocytes (iHeps), kits for generating iKCs, iKCs derived by the methods as described herein, combined cell populations comprising iKCs and iHeps. Methods of detecting immune-mediated responses to an agent using the iKCs, methods of treating a disease using the iKCs or the combined cell population comprising iKCs and iHeps are also described herein.

IPC Classes  ?

• C12N 5/0786 - Monocytes; Macrophages
• A61K 35/14 - Blood; Artificial blood
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates, in general terms, to cancer biomarkers. Disclosed herein are methods of identifying cancers that are suitable for NF-κB inhibition therapy, and methods of selecting subjects for the same, comprising detecting an indicator that is indicative of a level or activity of Protein polybromo-1 (PB1) in a sample obtained from the subject, wherein the cancer is identified as being likely to be responsive to the inhibitor of NF-κB signalling when the level or activity of PB1 indicated by the indicator corresponds to an absence or decreased level or activity of PB1 in the sample as compared to a control.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• A61K 31/69 - Boron compounds
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein are a method of identifying therapeutically potent mesenchymal stem cells (MSCs) and a method of distinguishing MSCs from human fibroblasts, comprising detecting HOXA9 expression in the cell. Also disclosed is a method of treating diseases in a subject in need of MSCs, comprising modifying MSCs to overexpress HOXA9 and administering the modified MSCs to the subject in need.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 19/00 - Drugs for skeletal disorders

Abstract

In some aspects, a hand-held probe for a Raman spectroscopy system is provided. The hand-held probe includes an excitation module, configured to emit a light beam along a light path; a beam splitter, oriented to reflect the light beam along the observation axis; an objective module, configured to receive the reflected light beam and transmit the reflected light beam to an object so as to generate a scattered light beam by the object, and configured to receive and transmit the scattered light beam to the beam splitter; a focusing mirror, configured to focus the refracted light beam from the beam splitter to a focus so as to generate a focused light beam; and an emission module, disposed at the focus and configured to receive the focused light beam, wherein the emission module is disposed at a same side as the excitation module with respect to the observation axis.

IPC Classes  ?

• G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
• G01J 3/44 - Raman spectrometry; Scattering spectrometry
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 21/65 - Raman scattering

Abstract

The present invention relates to cell biology. In particular, the present invention teaches methods of contacting the cells with a LING complex inhibitor to inhibit durotaxis and, in consequence, reduce fibrosis and metastasis. Methods of treating wound healing are also disclosed herein.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 11/16 - Central respiratory analeptics
• A61P 3/04 - Anorexiants; Antiobesity agents
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

There is provided a method detecting the presence of a nucleic acid in a sample, the method comprises performing an amplification reaction on the sample in the presence of a proofreading polymerase and a primer with a 2'-sugar modification. Also provided is a method of identifying a disease in subject and a kit for detecting a nucleic acid in a sample.

IPC Classes  ?

• C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection

Abstract

There are provided a method of treating a solid contact and a solid contact obtained from the method. There are also provided a method of preparing an ion-selective electrode and an ion-selective electrode prepared by the method. There is further provided a method of sensing an ion in a sample.

IPC Classes  ?

• G01N 27/333 - Ion-selective electrodes or membranes
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
• H01G 11/48 - Conductive polymers
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule

Abstract

The present disclosure concerns a method of biosynthesizing an antimicrobial compound of Formula (I), the method comprising culturing a microbial cell that is engineered to overexpress fatty-acyl CoA synthase (FAS) or RedD; and isolating the antimicrobial compound of Formula (I) that is produced by the microbial cell; wherein the biosynthesis of antimicrobial compound of Formula (I) is upregulated by at least about 2-fold compared to a tetramic acid analogue derived from a wild type microbial cell. The present disclosure also concerns a compound of Formula (I) and their use in treating a microbial disease or condition.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61P 31/04 - Antibacterial agents
• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces

Abstract

A leaching device (10) is provided. The leaching device (10) includes a motor (12) and a receptacle (14) rotatably coupled to the motor (12), the receptacle (14) being configured to receive a sample container. A plurality of ultrasonic transducers (16) is 5 attached to the receptacle (14). An ultrasonic generator (18) is coupled to the ultrasonic transducers (16). When in use, the ultrasonic generator (18) is configured to energise the ultrasonic transducers (16) to radiate ultrasonic waves to sonicate a sample in the sample container received in the receptacle (14). A controller (20) is configured to control operation of the motor (12) and the ultrasonic generator (18), the motor (12) and the 0 ultrasonic generator (18) being simultaneously operable.

IPC Classes  ?

• B01F 29/00 - Mixers with rotating receptacles
• B01F 31/80 - Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
• G01N 33/24 - Earth materials
• G01N 1/28 - Preparing specimens for investigation

Abstract

There is provided an antigen binding protein that specifically binds to yellow fever virus wherein the antigen binding protein comprises (1) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 1-3 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 7-9; or (2) CDRL1-CDRL3 respectively comprising sequences of SEQ ID NOs: 4-6 and CDRH1-CDRH3 respectively having sequences of SEQ ID NOs: 10-12. Also disclosed are polynucleotides, vectors, and host cells expressing the antigen binding protein thereof. Also disclosed are methods of detecting, kits, and methods of preventing or treating a yellow fever virus infection in a subject in need thereof.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present disclosure provides antigen-binding molecules that bind to CD30, having novel biophysical and/or functional properties as compared to antigen-binding molecules disclosed in the prior art. Also provided is a chimeric antigen receptor (CAR) comprising the novel CD30-specific antigen-binding molecules. Also provided is a nucleic acid or plurality of nucleic acids encoding said antigen-binding molecule or CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

MalasseziaMalassezia species.

IPC Classes  ?

• C12P 7/24 - Preparation of oxygen-containing organic compounds containing a carbonyl group
• C12N 1/16 - Yeasts; Culture media therefor
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
• C12R 1/645 - Fungi

Abstract

Disclosed are modified galactose oxidase variants with enhanced protein expression, solubility, thermal stability, and enzymatic activity, and reduced enantioselectivity compared to wild-type galactose oxidase or galactose oxidase variants known in the art, and methods of producing the same.

IPC Classes  ?

• C12P 7/26 - Ketones
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 15/52 - Genes encoding for enzymes or proenzymes

Abstract

The present disclosure provides an antigen-binding molecule comprising a single domain antibody sequence that binds to B7-H3. It also discloses a chimeric antigen receptor (CAR) construct comprising said antigen-binding molecule, encoding nucleic acid/expression vector and T cells expressing said CAR and the use of the CAR-expressing T cells in a method of medical treatment, prophylaxis, and treatment of cancer.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• G01N 33/563 - Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
• A61P 35/00 - Antineoplastic agents

Abstract

The present application describes novel chimeric antigen receptor (CAR) constructs comprising novel spacer region sequences. Also provided are cells comprising the CAR, a nucleic acid or a plurality of nucleic acids encoding the CAR, an expression vector or a plurality of expression vectors comprising said nucleic acids, methods of making such molecules, and the use of such molecules in a method of medical treatment or prophylaxis.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

This invention relates to microbiome markers for healthy aging. There is provided, inter alia, a method of predicting or determining healthy aging in an individual, the method comprising: (a) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1A, wherein an enrichment of said microorganisms is indicative of healthy aging; and/or (b) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1 B, wherein a depletion of said microorganisms is indicative of healthy aging.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

A photovoltachromic device is provided. The photovoltachromic device may include a photovoltaic cell, and a transparent-reflective switchable device in light communication with the photovoltaic cell. The transparent-reflective switchable device may be operable between a reflective mode in which light falling thereon is reflected to the photovoltaic cell, and a transmission mode in which light falling thereon is directed through the transparent-reflective switchable device.

IPC Classes  ?

• H02S 40/22 - Light-reflecting or light-concentrating means
• H02S 20/20 - Supporting structures directly fixed to an immovable object
• G02F 1/157 - Structural association of cells with optical devices, e.g. reflectors or illuminating devices
• A01G 9/24 - Devices for heating, ventilating, regulating temperature, or watering, in greenhouses, forcing-frames, or the like
• A01G 9/22 - Shades or blinds for greenhouses, or the like

Abstract

actinomycetesactinomycetesactinomycetes bacterium. In one embodiment, the metabolite is valinomycin, daidzein, fluvirucin, demethyllydicamycin, or TPU-0037 analogues A, C and D.

IPC Classes  ?

• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
• C12R 1/465 - Streptomyces

Abstract

Various embodiments refer to a light modulating device. The device may include a first support comprising a first photovoltaic cell on a surface and a first light-reflector on an opposing surface, and a second support comprising a second photovoltaic cell on a surface and second light-reflector on an opposing surface. The first support and the second support may be pivotably coupled to each other along an edge portion of the respective support, and movable between a collapsed position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell are opposed and inwardly facing and an extended position in which the surfaces comprising the first photovoltaic cell and the second photovoltaic cell lie substantially in the same plane, to modulate transmission of light.

IPC Classes  ?

• H02S 20/30 - Supporting structures being movable or adjustable, e.g. for angle adjustment
• H02S 30/20 - Collapsible or foldable PV modules
• F24S 30/48 - Arrangements for moving or orienting solar heat collector modules for rotary movement with three or more rotation axes or with multiple degrees of freedom
• A01G 9/24 - Devices for heating, ventilating, regulating temperature, or watering, in greenhouses, forcing-frames, or the like
• A01G 9/22 - Shades or blinds for greenhouses, or the like

Abstract

There is provided a method of converting polypropylene (PP) to oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures, the method comprising: oxidizing a PP containing source in the presence of a catalyst to obtain OPP; dissolving the OPP in a first liquid to obtain a dissolved solution of OPP; and precipitating OPP micro-sized particles having hierarchical nanostructures from the dissolved solution of OPP by adding the dissolved solution of OPP to a second liquid. Also provided is a material comprising oxidized polypropylene (OPP) micro-sized particles having hierarchical nanostructures.

IPC Classes  ?

• C08F 10/06 - Propene
• C08J 11/08 - Recovery or working-up of waste materials of polymers without chemical reactions using selective solvents for polymer components
• C08J 3/14 - Powdering or granulating by precipitation from solutions
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The invention relates generally to field of cancer biology. Provided herein are methods of inhibiting epithelial- mesenchymal transition (EMT) and for inhibiting or preventing metastasis in a cancer cell, the methods comprising contacting the cancer cell with an effective amount of a histone deacetylase 6 (HDAC6) inhibitor and a glycogen synthase kinase-3[3 (GSK30) inhibitor. Methods of screening for an inhibitor of EMT comprising a reporter cell line, which comprises a ZEB1 inducible construct, and an epithelial gene reporter construct are also provided herein.

IPC Classes  ?

• A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61P 35/00 - Antineoplastic agents

Abstract

A sound absorption material and a method (10) of fabricating a sound absorption material are provided. The method (10) includes preparing (12) a first precursor solution or suspension of one of a first triboelectric material and a second triboelectric material; and forming (16) a porous structure by using the first precursor solution or suspension in one of a templating technique with a second precursor solution or suspension of the other one of the first and second triboelectric material, an immersion technique with the other one of the first and second triboelectric materials, and an electrospinning technique with the other one of the first and second triboelectric materials. The porous structure includes a hybrid composite of the first triboelectric material having a first charge affinity and the second triboelectric material having a second charge affinity, wherein the first charge affinity is greater than the second charge affinity.

IPC Classes  ?

• G10K 11/162 - Selection of materials
• G10K 11/165 - Particles in a matrix
• E04B 1/84 - Sound-absorbing elements

Abstract

Various embodiments may relate to an optical system. The optical system may include a plurality of color filters, a first color filter of the plurality of color filters configured to select light of different wavelength ranges representing different color channels. The optical system may also include a plurality of metalenses, each of the plurality of metalenses associated with a respective color channel of the plurality of color channels. Each of the plurality of metalenses may have a focal length, the plurality of metalenses having equal focal lengths such that the different color channels are combined on a common focal plane to form a multi-color image. Each of the plurality of metalenses may include a plurality of nanostructures, have a (FOV) field of view of more than 30 degrees, and a desired working spectral bandwidth dependent on an extended depth of focus, a central wavelength of the associated color channel, and the focal length at the central wavelength.

IPC Classes  ?

• G02B 1/00 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements
• H04N 23/10 - Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• H04N 23/55 - Optical parts specially adapted for electronic image sensors; Mounting thereof

Abstract

A neural processing core for a neural network is provided, which includes: a synaptic memory array including synaptic memory cells arranged in a plurality of memory cell rows and columns; a plurality of first input activation lines connected to the plurality of memory cell rows, respectively, of the synaptic memory array and configured to receive a plurality of first input activation signals, respectively, to the plurality of memory cell rows; and a plurality of first sensing lines connected to the plurality of memory cell columns, respectively, of the synaptic memory array and configured to output a plurality of first analog electrical signals, respectively, from the plurality of memory cell columns. In particular, the neural processing core is configured to control the synaptic memory cells of the synaptic memory array in a column-wise manner. There is also provided a corresponding method of operating the neural processing core for a neural network.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron

Abstract

Antigen binding molecules capable of binding to calnexin (CNX) are disclosed herein. Also disclosed are chimeric antigen receptors, antibody-drug conjugates, and compositions comprising such antigen binding molecules, as well as nucleic acids, vectors and cells. Uses and methods involving antigen binding molecules capable of binding to calnexin (CNX) are also disclosed.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

Various embodiments may relate to an optical system. The optical system may include a laser source for emitting one or more laser beams. The optical system may also include a metalens, a first stage mounting the metalens, a first motor configured to move the first stage, a second stage for holding a sample, and a second motor configured to move the second stage. The optical system may include an objective, a third stage configured to hold the objective, and a third motor configured to move the third stage. The optical system may also include a detector and a screen including or defining a pinhole, the screen arranged between the objective and the detector. The optical system may also include a processor in electrical communication with the first motor, the second motor and the third motor.

IPC Classes  ?

• G03F 7/20 - Exposure; Apparatus therefor
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor

Abstract

BRD4BRD4CHEK1CHEK1CHEK1 gene. The invention also relates to the use of SSOs as therapeutic candidates for treating Myc-driven cancers.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

A method of identifying one or more bacteria from a sample, wherein the one or more bacteria is suspected to be present in the sample, is provided. The method may include providing an aqueous suspension comprising a bacteria-SERS nanoparticle complex, wherein the bacteria-SERS nanoparticle complex comprises (i) a SERS nanoparticle and (ii) the one or more bacteria suspected to be present in the sample; depositing the aqueous suspension comprising the bacteria-SERS nanoparticle complex on a substrate having structures coated with a SERS-active material to dispose the bacteria-SERS nanoparticle complex on the substrate; irradiating the bacteria-SERS nanoparticle complex disposed on the substrate with laser to generate one or more SERS signals; having a SERS-spectroscopic module operable to render one or more SERS spectral data corresponding to the one or more SERS signals; and having a process module operable to identify the presence or absence of the one or more bacteria from the one or more SERS spectral data.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• G01N 21/65 - Raman scattering

Abstract

The present invention relates to splice-switching oligonucleotides (SSOs) capable of altering the slicing of a pre-mRNA encoding a variant of the SLC25A13 gene, as well as the use of the same SSOs for treating citrin deficiency. In an embodiment, a SSO that binds to a site within a target region present on a pre-mRNA transcript of the SLC25A13 gene, wherein the binding of the SSO induces the exclusion of SLC25A13-PE5 from a mature mRNA transcript of the SLC25A13 gene. In another embodiment, the target region having at least 95% sequence identity to SEQ ID NO: 28.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 3/00 - Drugs for disorders of the metabolism

Abstract

An analyser (10, 100) for pollutant detection and a computer-implemented method (200) for pollutant detection are provided. The analyser (10, 100) includes one 5 or more electrochemical detection units (12, 102), one or more processors (14), a non-transitory computer-readable memory (16) and a display (18). Each of the one or more electrochemical detection units (12, 102) is configured to receive a control voltage signal according to a pollutant-specific detection protocol and output a measured current signal based on a measured electrical current from an electrode chip (20). The non-transitory 0 computer-readable memory (16) stores a detection protocol for each of a plurality of pollutants, a characterisation curve for each of the pollutants and computer program instructions executable by the one or more processors (14) to perform operations for pollutant detection, the operations comprising: identifying a current peak in the measured current signal; determining a peak intensity corresponding to the identified current peak; 5 and determining a concentration of a selected pollutant from the characterisation curve of the selected pollutant based on the determined peak intensity. The display (18) is configured to display the concentration of the selected pollutant.

IPC Classes  ?

• G01N 27/416 - Systems
• G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells

Abstract

A system for classification of basal cell carcinoma (BCC) and a method of classifying basal cell carcinoma (BCC) may be provided, the system comprising a processing module configured to receive an input image sequence comprising a plurality of images; and a prediction module coupled to the processing module, the prediction module comprising a hierarchical ensemble structure of a plurality of classification models; wherein the processing module is configured to process each image as a whole image to obtain a plurality of first sub-sections and to further process each first sub-section to obtain a corresponding plurality of second sub-sections; further wherein the processing module is configured to transmit the each first sub-section to a first classification model of the prediction module trained to process the first sub-sections and to transmit each of the corresponding plurality of second sub- sections to a second classification model of the prediction module trained to process the second sub-sections, further wherein the prediction module is configured to determine a probability of BCC of the each image of the input image sequence based on a plurality of respective block prediction results corresponding to the first sub-sections of the each image; and further wherein the prediction module is configured to determine a BCC classification of the input image sequence based on the determined probability of BCC of each image of the input image sequence.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06N 20/20 - Ensemble learning
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; iincubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The disclosure relates to methods of treatment and methods of identifying subjects for such treatment based on levels of pirin and/or iron in samples from the subject. In one embodiment, the subject is suffering from cancer, such as colorectal cancer, hemochromatosis or anaemia. In one embodiment, the treatment includes administration of iron chelator or pirin inhibitor.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 33/84 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61P 35/00 - Antineoplastic agents

Abstract

There is provided a nucleic acid construct comprising one or more internal ribosome entry site (IRES), one or more gene of interest, and a pair of site-specific recombinase, wherein the gene of interest is a heparan sulfate variant gene, a heparan sulfate modification enzyme gene, and/or a heparan sulfate scaffold protein gene. Also disclosed are a vector, a host cell and / or cell line, recombinant heparan sulfates, methods, kits for use thereof.

IPC Classes  ?

• C08B 37/00 - Preparation of polysaccharides not provided for in groups ; Derivatives thereof
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

The present invention relates to a koji mold fermentation product of a cereal-derived material which has an arabinan concentration of 5 mg/g or less. The present invention also relates to a method for producing a koji mold fermentation product of a cereal-derived material, said method comprising treating the cereal-derived material with an arabinase and a cellulase and fermenting the thus treated material using koji mold.

IPC Classes  ?

• C12P 1/02 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymes; General processes for the preparation of compounds or compositions by using microorganisms or enzymes by using fungi
• C12N 1/14 - Fungi ; Culture media therefor
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase

Abstract

The present disclosure concerns enzymes and their uses in biocatalytic halogenation of pyrrolic heterocycles thereof. The method of halogenating a 2', 3' and/or 5' substituted N-heteroaryl or a derivative thereof comprises contacting the N-heteroaryl or derivative thereof with a halogen and a flavin-dependent halogenase under co-enzyme regeneration conditions in order for the halogen to be substituted at a 4' position on the N-heteroaryl or derivative thereof.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12P 13/00 - Preparation of nitrogen-containing organic compounds

Abstract

The present invention relates, in general terms, to TEAD targeting compounds and 5 methods thereof.

IPC Classes  ?

• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07D 213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• C07D 231/40 - Acylated on said nitrogen atom
• C07D 249/06 - 1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
• A61K 31/10 - Sulfides; Sulfoxides; Sulfones
• A61K 31/415 - 1,2-Diazoles
• A61K 31/426 - 1,3-Thiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure provides an anti-bacterial peptide comprising ENOS or SPARCL1, or partial sequences thereof. The present disclosure also provides a conditioned cell culture media comprising the anti-bacterial peptide, wherein the conditioned cell culture media is made by culturing adipose-derived mesenchymal stem cells. The technology also relates to a method of treating infections using the peptides.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 31/04 - Antibacterial agents

Abstract

Described herein are compositions containing branched polyethylenimine and polypropylene glycol covalently bonded to the branched polyethyleneimine, where a molar ratio of the propylene glycol to the branched polyethylenimine is more than 3.35:1, and the polypropylene glycol is hydrophobic. The compositions may be used as a hydrogel and changes between a solution phase and a gel phase by changes in pH or temperature.

IPC Classes  ?

• C08G 71/00 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a ureide or urethane link, otherwise than from isocyanate radicals
• C08J 3/075 - Macromolecular gels
• C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
• C08L 75/08 - Polyurethanes from polyethers
• C08L 75/12 - Polyurethanes from compounds containing nitrogen and active hydrogen, the nitrogen atom not being part of an isocyanate group
• C08G 73/04 - Polyamines derived from alkyleneimines
• C08G 65/02 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring

Abstract

There is provided a ribozyme comprising: a) one or more catalytic domains capable of switching between an active state and an inactive state; b) one or more releasable RNA segments, wherein each of said releasable RNA segments is flanked by two ribozyme cleavage sites, wherein cleavage at each cleavage site is catalysed by at least one of the one or more catalytic domains in an active state; c) one or more trigger-binding domains, each of which is for the binding of a trigger nucleic acid molecule; wherein each of the one or more catalytic domains is linked to one of the one or more trigger-binding domains; wherein the catalytic domain is in an inactive state when the trigger-binding domain linked to said catalytic domain is not bound by the trigger nucleic acid molecule, and wherein the catalytic domain is in an active state when the trigger-binding domain linked to said catalytic domain is bound by the trigger nucleic acid molecule; and wherein when both cleavage sites flanking a releasable RNA segment are cleaved when catalysed by the one or more catalytic domains, the one or more releasable RNA segment is released from the ribozyme. Also disclosed are methods of detecting presence of a trigger nucleic acid molecule in a sample, methods of detecting presence of a sequence or mutation of interest on an nucleic acid of interest in a sample, and kits comprising the ribozymes thereof.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention relates to a method comprising the detection of LOC105375914 RNA in a glioma sample obtained from a subject, wherein an elevated level of LOC105375914 RNA as compared to a reference indicates that the subject has a high grade glioma, has a likelihood of resistance to chemotherapy, has a likelihood of recurrence, and/or is likely to have a poor prognosis. The present invention also relates to a method of treating a glioma expressing LOC105375914 RNA in a subject by administering an inhibitor of the LOC-DEAH-box helicase 15 (DHX15) complex to the subject.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/404 - Indoles, e.g. pindolol
• A61P 35/00 - Antineoplastic agents

Abstract

There is provided a regenerative material for skin, bone and/or cartilage tissue regeneration, the material comprising, a hyaluronic acid-based synthetic copolymer having one or more repeating units represented by general formula (Vlll-a). Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, hyaluronic acid-based macromolecule, and a method of preparing said hyaluronic acid-based macromolecule.

IPC Classes  ?

• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• A61K 31/728 - Hyaluronic acid
• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
• A61L 15/28 - Polysaccharides or their derivatives

Abstract

Immune cells comprising modification to increase the expression or activity of SERPINB9 are disclosed. Also disclosed are compositions comprising such cells and methods of using such cells and compositions.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• C07K 14/81 - Protease inhibitors

Abstract

Various embodiments may relate to a fluid extraction apparatus. The fluid extraction apparatus may include a syringe holder configured to hold one or more syringes, and a first linear actuator configured to move the syringe holder into a position for loading of a syringe of the one or more syringes. The fluid extraction apparatus may also include a stand, a rotary platform on the stand, and a vial holder on the rotary platform. The fluid extraction apparatus may also include a cap gripper on the rotary platform, a rotary actuator configured to rotate the rotary platform between a first configuration and a second configuration, a second linear actuator configured to actuate a plunger of the syringe such that the syringe extracts at least the portion of the fluid, and a controller configured to control the first linear actuator, the second linear actuator, and the rotary actuator.

IPC Classes  ?

• B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars

Abstract

Methods and systems for facilitating analysis of a skin condition are provided. The methods apply a deep neural network (DNN) to a digital skin image to identify or prepare a digital lesion skin image for further processing. Further processing can involve calculating an asymmetry (A) score based on a feature vector produced by combining feature vectors derived from the digital lesion skin image, calculating a border score based on the regularity of a lesion or skin condition, calculating a colour score based on colours detected in the digital lesion skin image, calculating a dermatoscopic score based on a presence of dermatoscopic features or structures in a digital skin lesion image, and finally calculating a final score based on the asymmetry, border, colour and dermatoscopic scores, the final score indicating a likelihood of the skin condition.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/28 - Quantising the image, e.g. histogram thresholding for discrimination between background and foreground patterns
• G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
• G06V 10/56 - Extraction of image or video features relating to colour

Abstract

Disclosed herein a method of treating a BAP1 -related tumour in a subject, the method comprising determining whether BAP1 in the sample is functional or non-functional, and administering to the subject a therapeutically effective amount of a PARP inhibitor and a LSD1 inhibitor if BAP1 in the sample is non-functional. Also disclosed herein is a method screening and identifying an anti-proliferative compound, the method comprising obtaining a population of BAP1-deficient cells, treating said BAP1 -deficient cell population with the anti-proliferative compound, and determining a change in proliferative activity of the population of BAP1 -deficient cells compared to a population of cells producing functional BAP1 protein.

IPC Classes  ?

• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/502 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

The invention relates to generally to the field of molecular biology. In particular, the invention is directed to a vector for generating a circular RNA. Methods for generating circular RNA from a precursor RNA transcribed from the vector are also provided herein.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

The present invention relates generally to the field of pluripotent stem cell. In particular, the invention relates to a serum- free method for differentiating pluripotent stem cells into multipotent mesenchymal stem cells (MSCs). The invention also relates to serum-free composition for differentiating pluripotent stem cells into multipotent MSCs, the composition comprising Dulbecco's Modified Eagle Medium (DMEM), KnockOut™ serum (KOSR), and GlutaMAX.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

A method and system for navigating a robot 100 in a designated environment are provided herein. In an embodiment, the method comprises: selectively identifying reference features from a scale plan of the designated environment; generating a topometric map 178 of the designated environment, the topometric map 178 being associated with the identified reference features; generating an initial navigation path 176 of a local region 174 from the topometric map 178; as the robot 100 navigates along the initial navigation path 176 of the local region 174, detecting on-site reference features of the local region 174 that correspond to the identified reference features of the scale plan; and updating the topometric map 178 based on the correspondence to generate a regional path plan 188 to guide the robot's direction in the local region 174.

IPC Classes  ?

• G01C 21/30 - Map- or contour-matching
• G05D 1/02 - Control of position or course in two dimensions

Abstract

Method and system for localising a robot 100 using a scale plan of a designated environment are provided herein. In an embodiment, the method comprises: identifying reference features from the scale plan 136; generating a predicted pose 156 of the robot's current location on the scale plan 136 based on the identified reference features; scanning on-site reference features 186 of the current location; generating a map 158 for the current location to localise the robot 100, based on the scanned on-site reference features 186 of the current location and last N frames of historical scans of previous on-site reference features 186 of a plurality of locations in the designated environment that the robot traversed through before reaching the current location; the last N frames being fewer than total frames of the historical scans of the previous on-site reference features 186.

IPC Classes  ?

• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G01C 21/30 - Map- or contour-matching
• G16Y 40/60 - Positioning; Navigation

Abstract

There is provided an implant configured to be deployed in an eye by a deployer tool to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, the implant comprising, an elongate member having a proximal segment configured to be disposed in the posterior chamber of the eye and a distal segment configured to be disposed in the suprachoroidal space of the eye, wherein the elongate member is configured to maintain a bent configuration that substantially complies with anatomical curvatures of the posterior chamber and the suprachoroidal space, when deployed in the eye. There is also provided a deployer tool for inserting an implant as disclosed herein into an eye to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, and a system for facilitating the conduction of fluid from a posterior chamber to a suprachoroidal space of an eye.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery

Abstract

A method for tracking one or more living objects using at least one processor is provided. The method includes: receiving, via a plurality of receiving antennas, signals transmitted from a plurality of transmitting antennas; identifying a location of each of the one or more living objects with respect to a discrete time based on the signals received in a number of a sampling periods; determining a movement of each of the one or more living objects based on the identified location; determining one or more vital signs of each of the one or more living objects based on the movement of each of the one or more living objects; and tracking collectively the location and the one or more vital signs of each of the one or more living objects.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
• G01S 13/36 - Systems for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/113 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing

Abstract

A method and system for navigating a robot 100 are provided herein. In an embodiment, the method comprises: detecting on-site reference features of the robot's location when the robot is traversing in an environment; identifying objects of interest 180 from the detected on-site reference features; deriving a semantic data for each object of interest 180 from the on-site reference features; generating a semantic cost map 166 based on the semantic data of the objects of interest 180, the semantic cost map 166 representing cost of traversing in the environment; and navigating the robot 100 based on the semantic cost map 166.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions
• G01C 21/00 - Navigation; Navigational instruments not provided for in groups
• G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestrians; Recognition of traffic objects, e.g. traffic signs, traffic lights or roads

Abstract

Disclosed herein is a combination that includes a F1F0-ATP synthase inhibitor or a pharmaceutically acceptable salt or solvate thereof that selectively binds to the F1 domain of the F1F0-ATP synthase in combination with one or more of the compounds selected from: (a) an NADH dehydrogenase inhibitor or a pharmaceutically acceptable salt or solvate thereof; (b) a cytochrome-bcc:aa3 inhibitor or a pharmaceutically acceptable salt or solvate thereof; and (c) a F1F0-ATP synthase inhibitor or a pharmaceutically acceptable salt or solvate thereof that selectively binds to the F0 domain of the F1F0-ATP synthase.

IPC Classes  ?

• A61P 31/06 - Antibacterial agents for tuberculosis
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/451 - Non-condensed piperidines, e.g. piperocaine having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

There is provided a system and method of detecting a direction of arrival of one or more target signals using an antenna array, the method comprising, i) generating a map representing a ratio of a co-polarization (Co-pol) pattern received by the first beam to a cross- polarization (X-pol) pattern received by the second beam; ii) obtaining Co-pol and X-pol signal strengths of the one or more target signals received by the first and second beams in step (i); iii) obtaining the Co-pol to X-pol ratio of each of the one or more target signals; iv) normalizing the generated map; v) normalizing the Co-pol to X-pol ratios of the one or more target signals; and vi) for each target signal: finding area(s), within the normalized generated map, which substantially match the normalized Co-pol to X-pol ratio of the target signal; and identifying said area(s) of the normalized generated map as potential direction(s) of arrival of the target signal.

IPC Classes  ?

• G01S 3/04 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using radio waves - Details
• H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

This document describes a two-dimensional discrete Fourier transform (DFT) hardware accelerator comprising an ultrasonic transmitter configured to convert input signals to I/Q ultrasonic waves which are then transmitted to a lens, and an ultrasonic receiver configured to receive and convert ultrasonic waves to baseband signals, whereby the lens is provided between the transmitter and the receiver, and whereby the I/Q ultrasonic waves transmitted by the transmitter will superimpose on the lens before being received by the receiver.

IPC Classes  ?

• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

There is provided an antenna system and a method of forming an antenna system, the antenna system comprising, a base member having a cavity defined on a surface thereof; a tunable material layer disposed within the cavity of the base member; a substantially planar substrate coupled to the base member such that a first side of the substrate is in contact with the tunable material layer; and a radiator coupled to a second side of the substrate such that the substrate is between the radiator and the base member, said radiator comprising an array of grid cells configured to generate a beam upon excitation thereof; wherein the tunable material layer comprises a tunable material capable of changing its dielectric constant in response to a variable biasing voltage applied between the radiator and the base member, such that one or more properties of the beam changes according to the dielectric constant of the tunable material.

IPC Classes  ?

• H01Q 3/44 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the electric or magnetic characteristics of reflecting, refracting, or diffracting devices associated with the radiating element
• C09K 19/02 - Liquid crystal materials characterised by optical, electrical or physical properties of the components, in general
• H01Q 19/09 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using refracting or diffracting devices, e.g. lens wherein the primary active element is coated with or embedded in a dielectric or magnetic material
• H01Q 21/00 - Antenna arrays or systems

Abstract

The present disclosure relates to Brillouin Optical Time Domain Analysis (BOTDA) based method and system for improving dynamic strain measurements in distributed fiber optical sensor which involve application of a total variation (TV) filter on a raw image to produce a denoised image which includes a numeral solution. The present disclose also relates to ascertaining two or more evaluation parameters selected from the group consisting of image peak signal to noise ratio (PSNR), similarity structure index metrics (SSIM), and strain vector correlation coefficient (corr_coef) and mean square error (MSE), and also the evaluation performance indicator based on a combination thereof for comparing performance of various denoising approaches.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G01D 5/353 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre

Abstract

A system and a method for incremental learning in machine translation may be provided, the system comprises an input module for obtaining a source language input to be translated into a target language output; an ensemble model module coupled to the input module, the ensemble model module comprising a baseline model trained using a first dataset, the baseline model arranged to receive the source language input to generate a baseline model target language output with associated one or more baseline model probability scores; at least one first adapted model trained using a second dataset, the second dataset being smaller than the first dataset, the at least one first adapted model arranged to receive the source language input to generate a first adapted model target language output with associated one or more first adapted model probability scores; and a determination module coupled to the ensemble model module for receiving the one or more baseline model probability scores and the one or more first adapted model probability scores, the determination module arranged to generate a system target language output based on the received one or more baseline model probability scores and the received one or more first adapted model probability scores.

IPC Classes  ?

• G06F 40/44 - Statistical methods, e.g. probability models
• G06N 20/20 - Ensemble learning

Abstract

There is provided a polymerizable composition comprising at least one monomer of a thermoplastic polymer and at least one monomer of thermosetting resin. There is also provided a three-dimensional printed article comprising a plurality of thermoplastic structures embedded within a thermosetting resin, wherein the thermoplastic structures are comprised of monomers of a thermoplastic polymer. There is also provided a method of making the composition and a method of forming a three-dimensional printed article using the composition.

IPC Classes  ?

• C08L 33/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
• C08L 33/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• C08L 75/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds
• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• A61C 5/70 - Tooth crowns; Making thereof
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

Aspects concern a method for configuring a process comprising converting a neural network trained to map process inputs to process outputs to operate on data in encrypted domain of a predetermined encryption and decryption scheme such that the encryption of the encryption and decryption scheme is homomorphic with respect to the operation of the converted neural network, determining a desired process output in encrypted domain, determining an input in encrypted domain to the converted neural network leading to an output of the converted neural network approximating the desired process output in encrypted domain and providing the determined input for configuration of the process.

IPC Classes  ?

• G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
• G06N 3/084 - Backpropagation, e.g. using gradient descent
• H01L 21/00 - Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof

Abstract

Clinical decision support systems and methods for microorganism identification in a sample by determining long-read nucleic acid fragment sequence data (LRS data) originating from a plurality of species in the sample; performing taxonomic classification of the LRS data; determining an abundance levels of a plurality of reference genomes based on taxonomic identifiers of the LRS data; aligning the LRS data with a subset of the reference genomes; performing coverage analysis to determine an identity of one or more microorganism present in the sample based on the coverage analysis.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• C12Q 1/6869 - Methods for sequencing
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Systems and methods for outbreak analysis by performing taxonomic classification of the first LRS data to assign one or more taxonomic identifiers to each record in the first LRS data; identifying a plurality of species-specific candidate genomes from a reference genome database based on the assigned taxonomic identifiers; aligning the first LRS data with each of the plurality of species-specific candidate genomes to determine a first species identity of a microorganism species present in the sample; identifying a first nearest strain of the identified microorganism species present in the first sample by aligning the first LRS data with a plurality of strain-specific candidate genome dataset.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• C12Q 1/6869 - Methods for sequencing
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The present invention relates to methods of engineering and identifying a peptide aptamer using a library of peptide aptamers presented in an antibody variable domain (VH) that binds to a target protein of interest. In a specific embodiment, a library of VH-based peptide aptamers containing different linkers flanking the elF4E cap-interaction motif is screened against elF4E using phage and yeast surface displays. Several constrained macrocyclic peptide aptamers are identified to bind to elF4E cap-binding site. A live cell screening method using NanoBIT and the use of peptide aptamers for treating cancer are also disclosed.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• C12P 21/00 - Preparation of peptides or proteins
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure concerns compounds and methods thereof for treating proliferative diseases, fibrosis, inflammatory diseases and/or immune inflammatory 5 diseases. The present disclosure also concerns methods of inhibiting NF-κB-inducing kinase in a cell.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 35/00 - Antineoplastic agents
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

This disclosure relates to method and system for inspection of rotational components based on video frames of the rotational components in motion. Based on the property of projective single axis motion, motion trajectories of defects on the rotational components are modeled in a conic pattern. The defects are clustered according to their spatial information around a rotation axis of the rotational components to ascertain distinct defects. Undetected defects may be recovered by rotating their previous locations along their trajectory conics by a predetermined rotation angle. Based on the distinct defects, including the recovered defect, a modified video frame which includes an identification of the distinct defects, including the recovered defect, may be generated.

IPC Classes  ?

• G01N 21/89 - Investigating the presence of flaws, defects or contamination in moving material, e.g. paper, textiles
• G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries

Abstract

This disclosure relates to method and system for inspection of rotational components based on video frames having different camera views of defects on rotational components. Using optical flow to ascertain motion vectors of pixels of the video frames, the video frames are partitioned based on motion vectors. The partitioned regions are paired with corresponding regions in a subsequent video frame, and their features are matched. For video frames having at least camera motion, a transformation matrix is ascertained which is applied to map defect trajectories of each camera view to a subsequent camera view.

IPC Classes  ?

• G01N 21/89 - Investigating the presence of flaws, defects or contamination in moving material, e.g. paper, textiles
• G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries

Abstract

An epidermal biosensor comprising a diffusion layer operable to dissolve a solid-phase epidermal analyte, an enzymatic bioreceptor operable to oxidise the dissolved epidermal analyte from the diffusion layer, a transducer having an interface with the diffusion layer, a processor configured to process electrochemical data from the transducer, and a substrate to which the enzymatic bioreceptor and the transducer are attached. The solid-phase epidermal analyte may include water¬ insoluble cholesterol and water-soluble lactate. The diffusion-solvation layer may comprise agarose hydrogel and additives including glycerol and/or gelatin to improve mechanical robustness and reduce water evaporation rate of the hydrogel, and ethanol and/or Triton X-100 to facilitate solvation and transportation of hydrophobic analytes.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

According to embodiments of the present invention, an optical sensor is provided. The optical sensor includes a single piece of optical fiber including a modified fiber tip and a distal end opposite to the modified fiber tip. The distal end may be configured to optically communicate with an external light source and an external detector. The modified fiber tip may be configured to be positioned within a turbid medium to deliver light from the external light source to particles in the turbid medium, at least minimize the light being back reflected at the modified fiber tip and receive backscattered light from the particles for determining a real-time fluid property of the particles in the turbid medium by the external detector. According to further embodiments of the present invention, an optical apparatus, an optical arrangement, and a method for determining a real-time fluid property of the particles are also provided.

IPC Classes  ?

• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 21/85 - Investigating moving fluids or granular solids
• G02B 6/02 - Optical fibres with cladding
• A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Abstract

There is provided a bioink for bioprinting a porous three-dimensional hydrogel structure, the bioink comprising an aqueous medium; and granular crosslinkable hydrogel precursor particles suspended in the aqueous medium, wherein the granular crosslinkable hydrogel precursor particles have an average size of from 100 microns to 500 microns, and wherein under suitable crosslinking conditions, the granular crosslinkable hydrogel precursor particles crosslink and adhere to one another, to form the porous three-dimensional hydrogel structure having pore diameters in the range of from 20 microns to 200 microns. There is also provided a method of forming a porous three-dimensional hydrogel structure using the bioink disclosed herein and a porous three-dimensional hydrogel structure obtained from said method.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• B29C 64/10 - Processes of additive manufacturing
• B29C 64/40 - Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber; a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.

IPC Classes  ?

• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
• B29C 64/218 - Rollers
• A61F 2/10 - Hair or skin implants

Abstract

There is provided an array antenna and a method of generating circularly polarized beams using an array antenna, the array antenna comprising, a plurality of sub-arrays, each of the plurality of sub-arrays comprising, a plurality of antenna elements, each antenna element comprising a first feeding port and a second feeding port; a physical integrated circuit (IC) comprising a plurality of first and second output channels; a first feeding network comprising a plurality of first feed lines communicatively coupling each of the first output channels of the physical IC to a first feeding port of each of the plurality of antenna elements; and a second feeding network comprising a plurality of second feed lines communicatively coupling each of the second output channels of the physical IC to a second feeding port of each of the plurality of antenna elements; wherein the physical IC is configured to excite the plurality of antenna elements via the first feeding network to generate a first circularly polarized (CP) beam and to excite the plurality of antenna elements via the second feeding network to generate a second CP beam, and wherein the respective first CP beams from each of the plurality of sub-arrays form a first combined CP beam; and the respective second CP beams from each of the plurality of sub-arrays form a second combined CP beam.

IPC Classes  ?

• H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic
• H01Q 3/30 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase
• H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction

Abstract

The present invention relates to host cells comprising a first vector comprising a polynucleotide sequence encoding mevalonate pathway genes, and a second vector comprising a polynucleotide sequence encoding a geraniol diphosphate synthase (GPPS) and a Nudix hydrolase. In an embodiment, the host cell is an E. coli cell; the mevalonate pathway genes are HMG-CoA synthase (hmgS), acetoacetyl-CoA thiolase (afoB), HMG-CoA reductase (hmgR), mevalonate kinase (mevK), phosphomevalonate kinase (pirk), mevalonate pyrophosphate decarboxylase (pmd) and (isopentenyl diphosphate) IPP isomerase (/d/); the GPPS is E. coli IspA comprising a S80F mutation (ispA_S80F); and the Nudix hydrolase is RhNUDXI isolated from Rosa hybrida. Also disclosed are methods and kits for producing geraniol and geranyl acetate comprising culturing the host cells thereof. Furthermore, engineered fusion proteins comprising RhNUDXI and ispA_S80F are disclosed.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12P 7/02 - Preparation of oxygen-containing organic compounds containing a hydroxy group

Abstract

A semiconductor package for flip chip integration is described. In an embodiment, the semiconductor package 100 comprises an assembly 104 and a casing 118. The assembly 104 comprises: a first semi conductor die comprising a first semi conductor layer having one or more first devices on a front side and a first conductive layer 114 electrically connected to the one or more first devices on a back side; a first buffer 110 formed on the back side to electrically and thermally connect the first conductive layer 114 to an electrical contact 126 on the substrate 102; an insulating mold 108 adapted to encapsulate the first semiconductor die 106 and the first buffer 110 apart from a portion of a back surface of the first buffer 110 and a front surface of the first semiconductor die 106; and one or more redistribution layers 112 formed at the front surface to electrically connect the one or more first devices to one or more first electrical connections on a substrate 102. The casing 118 is adapted to electrically and thermally connect the first buffer 110 to the electrical contact 126, wherein the casing 118 is configured to at least partially enclose the assembly 104. Embodiments in relation to a method for forming the semiconductor package is also described.

Abstract

Escherichia coliEscherichia coli is catalase G (KatG).

IPC Classes  ?

• C12P 7/24 - Preparation of oxygen-containing organic compounds containing a carbonyl group
• C12N 1/21 - Bacteria; Culture media therefor modified by introduction of foreign genetic material
• C12R 1/19 - Escherichia coli

Abstract

Method and systems for defect detection in images by processing the target image using a reinforcement learning agent (RL agent) provided in a memory accessible to the processor to identify a coarse defect region in the target image, processing each coarse defect region using an object detection model (OD model) provided in the memory to identify a sub-region of the coarse defect region corresponding to a defect; wherein the OD model is trained using a low-resolution image dataset; and the RL agent is trained using a high-resolution image dataset.

IPC Classes  ?

• G06N 3/092 - Reinforcement learning
• G06V 10/84 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using probabilistic graphical models from image or video features, e.g. Markov models or Bayesian networks
• G06V 10/98 - Detection or correction of errors, e.g. by rescanning the pattern or by human intervention; Evaluation of the quality of the acquired patterns

Abstract

Various embodiments may relate to an acoustic transducer. The acoustic transducer may include a substrate including a cavity extending from a surface of the substrate, wherein the substrate further includes one or more acoustic channels, each of the one or more acoustic channels having a depth extending form the surface of the substrate and a length, the length greater than the depth, extending at least partially around the cavity. The acoustic transducer may also include a layered arrangement suspended over the cavity. The one or more acoustic channels may be configured to include an acoustic medium having a specific acoustic impedance lower than a specific acoustic impedance of the substrate.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• B06B 1/02 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy

Abstract

A computer-implemented method (10) for determining depth and location of localised thinning in a plate structure is provided. The computer-implemented method (10) for determining depth and location of localised thinning in the plate structure includes executing on one or more processors the steps of: selecting (12) a high-order symmetric Lamb wave mode; generating (14) the selected high-order symmetric Lamb wave mode in the plate structure using one or more first ultrasonic transducers attached to the plate structure; detecting (16) the generated high-order symmetric Lamb wave mode using the 0 one or more first ultrasonic transducers or one or more second ultrasonic transducers attached to the plate structure; comparing (18) arrival times of the detected high-order symmetric Lamb wave mode with a set of baseline signals to determine the depth of the localised thinning in the plate structure; and analysing (20) the arrival times of the detected high-order symmetric Lamb wave mode reflected from an edge of the localised thinning to determine the location of the localised thinning in the plate structure.

IPC Classes  ?

• G01N 29/07 - Analysing solids by measuring propagation velocity or propagation time of acoustic waves
• G01N 29/04 - Analysing solids
• G01N 29/44 - Processing the detected response signal

Abstract

Escherichia coliEscherichia coli cell.

IPC Classes  ?

• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12N 1/21 - Bacteria; Culture media therefor modified by introduction of foreign genetic material
• C12R 1/19 - Escherichia coli

Abstract

This invention relates to a co-culture system comprising a first population of cells and a second population of HBV producing cells separated from the first population of cells, wherein the first population of cells is capable of being continuously infected by the HBV continuously produced by the second population of HBV producing cells. The co-culture system is used for screening for at least one agent against HBV infection and identifying at least one agent as a HBV cccDNA-directed agent. In addition, methods for preventing or inhibiting cccDNA formation of HBV or HBV infection in a subject using compound selected from the group consisting of Bilastine, Pitolisant and Nizatidine, or a derivative thereof, are also provided.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
• A61K 31/426 - 1,3-Thiazoles
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 31/20 - Antivirals for DNA viruses

Abstract

In some aspects, a computer-implemented method using a chameleon hash function is provided. The chameleon hash function includes one or more modular exponentiations and one or more modular multiplications. The method includes, at a signature-verification phase: precomputing, at an offline phase of the signature-verification phase, at least partially each of the one or more modular exponentiations of the chameleon hash function; and evaluating, at an online phase of the signature-verification phase, the chameleon hash function based on the precomputed one or more modular exponentiations and one or more modular multiplications.

IPC Classes  ?

• H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
• G06F 21/64 - Protecting data integrity, e.g. using checksums, certificates or signatures
• H04W 12/106 - Packet or message integrity

Abstract

There is provided a composition comprising at least one epoxy precursor, at least one cross-linker, at least one chain extender, and an electrolyte, wherein the at least one epoxy precursor comprises at least three glycidyl groups per molecule. There are also provided a composite material, a method of forming the same and a capacitor comprising the same.

IPC Classes  ?

• H01B 1/20 - Conductive material dispersed in non-conductive organic material
• H01G 9/035 - Liquid electrolytes, e.g. impregnating materials
• C08G 59/50 - Amines
• C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08G 59/32 - Epoxy compounds containing three or more epoxy groups

Abstract

The present invention relates to the use of a compound of formula (I): to extend the chronological lifespan of a cell, a. method for extending the chronological lifespan of a cell, the compound for use in extending the chronological lifespan of a cell and the use of the compound in the manufacture of a. medicament for extending the chronological lifespan of a cell.

IPC Classes  ?

• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/282 - Platinum compounds
• A61K 31/295 - Iron group metal compounds
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/401 - Proline; Derivatives thereof, e.g. captopril
• A61P 39/00 - General protective or antinoxious agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

An ultrasonic transducer (10, 12) for structural health monitoring, a method (200) for producing an ultrasonic transducer (10, 12) for structural health monitoring, and a method (300) for structural health monitoring are provided. The ultrasonic transducer (10, 12) includes a piezoelectric film (14), a first electrode (16) on a first surface of the piezoelectric film (14), and a second electrode on a second surface of the piezoelectric film (14). The piezoelectric film (14) includes polylactic acid having aligned molecular chain orientation.

IPC Classes  ?

• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
• G01M 5/00 - Investigating the elasticity of structures, e.g. deflection of bridges or aircraft wings
• H01N 30/06 -
• H01N 30/098 -
• H01N 30/857 -
• G01L 1/16 - Measuring force or stress, in general using properties of piezoelectric devices

Abstract

The present invention relates generally to the field of molecular biology. In particular, the specification teaches methods of preventing or treating an RNA viral infection in a subject, comprising administering at a dose of 5x1011 to 5x1013 vgs/kg of a recombinant adeno-associated virus (AAV) to the subject, wherein the AAV comprises at least one heterologous nucleic acid sequence encoding a Cast 3 nuclease and one or more guide RNAs. In one embodiment, the RNA virus infection is an infection by Enterovirus 71.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention refers to a method for high-throughput screening of viability of cells, the method comprising the steps of: a) treating, in a well of a first multi-well plate, a sample containing cells with a condition that modulates lifespan; b) transferring a portion of the cells in the well of the first multi-well plate into a well of a second multi-well plate; c) mixing, in a well of the second multi-well plate, the portion of cells with a fluorescent viability dye to stain the cells; d) measuring fluorescence intensity of the stained cells in a plate reader to obtain a fluorescence intensity value; e) measuring optical density of the cells in the plate reader to obtain an optical density value; and f) normalizing the fluorescence intensity value with the optical density value, wherein the normalized fluorescence intensity value directly correlates with the viability of the cells.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper

Abstract

There is provided a method of forming a catalyst precursor, including the steps of: (a) forming a precipitate from a slurry, wherein the slurry comprises (i) a mixture of an iron precursor, at least one promotor precursor and a solvent and (ii) a solution of an alkali base; and (b) calcining the precipitate to form the catalyst precursor. There is also provided a catalyst precursor; a method of forming a catalyst; and a catalyst.

IPC Classes  ?

• B01J 27/22 - Carbides
• B01J 23/745 - Iron
• B01J 23/08 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of gallium, indium or thallium
• B01J 23/04 - Alkali metals
• B01J 23/75 - Cobalt
• B01J 27/224 - Silicon carbide
• B01J 37/03 - Precipitation; Co-precipitation
• B01J 37/18 - Reducing with gases containing free hydrogen
• B01J 37/08 - Heat treatment
• C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen

Abstract

Disclosed herein is a process for solubilizing a protein comprising the step of subjecting a dispersion of an untreated protein to a pressure in the range of 250 MPa to 650 MPa and a pH in the range of 1 to 3 or 9 to 14 to solubilize the untreated protein to form the solubilized protein. Disclosed herein is also a process of forming a food composition from the solubilized protein as described herein.

IPC Classes  ?

• A23J 3/14 - Vegetable proteins
• A23L 33/185 - Vegetable proteins

Abstract

Described herein is a method of imaging an inanimate structural implant in a tissue. The method includes positioning a magnetic particle imaging device proximal to the inanimate structural implant in the tissue, the inanimate structural implant coupled to at least one magnetic particle; exciting the at least one magnetic particle with a generated magnetic field from the magnetic particle imaging device; receiving a signal from the excited at least one magnetic particle; and constructing an image of the inanimate structural implant based on the signal. A method of heating an inanimate structural implant is also described, the method includes positioning a device proximal to the inanimate structural implant in the tissue, the device configured to generate alternating magnetic fields, the inanimate structural implant coupled to at least one magnetic particle; generating alternating magnetic fields with the device; and heating the inanimate structural implant with the generated alternating magnetic fields.

IPC Classes  ?

• A61B 5/0515 - Magnetic particle imaging
• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
• A61N 2/00 - Magnetotherapy

Abstract

Describe herein is a polyolefin composite and a method of preparation. The method includes blending a mixture comprising 50 to 94.9 weight percent (wt%) of a matrix polymer, 5 to 40 wt% of a reinforcement polymer; and 1 to 20 wt% of a crosslinked molecule and/or 0.1 to 10 wt% of a nanofiller to provide a blended mixture, wherein the weight percent of each component is with respect to the polyolefin composite; and forming the polyolefin composite from the blended mixture, wherein the matrix polymer is a first polyolefin with a number average molecular weight of at most 300,000, and the reinforcement polymer is a second polyolefin with a number average molecular weight of at least 1,500,000. The polyolefin composite includes the matrix polymer, the reinforcement polymer, and the crosslinked molecule and/or the nanofiller as described aforementioned.

IPC Classes  ?

• C08L 23/06 - Polyethene
• C08K 3/013 - Fillers, pigments or reinforcing additives
• D01F 6/46 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyolefins
• D01F 1/10 - Other agents for modifying properties

Abstract

invitrovitro 3D intestinal epithelial tissue model; (ii) dissociating tissues of the 3D intestinal epithelial tissue model into a single cell suspension culture; (iii) fixing cells of the single cell suspension culture with a fixative; and (iv) measuring a proportion of cells having micronuclei (MN) in the cells from step (iii) and measuring a proportion of cells having micronuclei in a control population of cells not exposed to the test compound, wherein an elevated proportion of cells from step (iii) having micronuclei relative to the control population of cells indicates that the test compound is genotoxic.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method. Finally, the present invention also refers to an in vivo method of detecting the survival rate of a retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in a subject and an in vitro method of determining the immunogenicity of said retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in said subject, to whom said differentiated RPE cell has been pre-delivered.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/12 - Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
• A61P 27/00 - Drugs for disorders of the senses

Abstract

There is provided a convolution engine configured to perform neural network computations. The convolution engine including: a plurality of convolution processing blocks, each convolution processing block being configured to perform convolution based on a 2D array of first feature map data stored therein to produce a set of first convolution outputs, each set of first convolution outputs including a plurality of channels; and a plurality of weight memory blocks communicatively coupled to the convolution processing blocks. Each weight memory block is configured to store and supply weight parameters to the corresponding convolution processing blocks to perform convolution. Each convolution processing block further comprises a plurality of processing element blocks and each processing element block can further comprise a plurality of sub-blocks and corresponding weight memory sub-blocks.

IPC Classes  ?

• G06F 17/15 - Correlation function computation
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Herein disclosed is an ex vivo method of identifying a state of a tumor margin in a sample. The method comprises operating a system to generate an ultrasound image and a photoacoustic image, wherein the system comprises: a probe configured to deliver a pulsed laser from a laser source to a sample, wherein the laser source is operable to generate the pulsed laser; arrays coupled to the probe, wherein one of the arrays comprises transducing elements arranged thereon which are operable to transmit and collect ultrasound signals, and wherein one of the arrays comprises transducing elements arranged thereon which are operable to collect photoacoustic signals; and a data acquisition module which converts the ultrasound signals and the photoacoustic signals into the ultrasound image and the photoacoustic image, respectively, identifying from the photoacoustic image the presence or absence of lipids and observing for a pattern and distribution of the lipids, identifying from the photoacoustic image the presence or absence of collagen and observing for a pattern and distribution of the collagen; identifying from the photoacoustic image the presence or absence of hemoglobin and observing for a pattern and distribution of the hemoglobin; and comparing from the photoacoustic image an intensity of the collagen and/or hemoglobin, if present, with an intensity of tissue proximal to the collagen and/or hemoglobin. Herein disclosed is a method of determining a state of a tumor.

IPC Classes  ?

• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The present invention relates generally to genomics. In particular, the specification teaches a method of predicting subjects at risk of rheumatoid arthritis and the responsiveness of a subject towards methotrexate (MTX) treatment.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis