Abstract

The present disclosure concerns compounds and methods thereof for treating proliferative diseases, fibrosis, inflammatory diseases and/or immune inflammatory 5 diseases. The present disclosure also concerns methods of inhibiting NF-κB-inducing kinase in a cell.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 35/00 - Antineoplastic agents
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

This disclosure relates to method and system for inspection of rotational components based on video frames of the rotational components in motion. Based on the property of projective single axis motion, motion trajectories of defects on the rotational components are modeled in a conic pattern. The defects are clustered according to their spatial information around a rotation axis of the rotational components to ascertain distinct defects. Undetected defects may be recovered by rotating their previous locations along their trajectory conics by a predetermined rotation angle. Based on the distinct defects, including the recovered defect, a modified video frame which includes an identification of the distinct defects, including the recovered defect, may be generated.

Abstract

This disclosure relates to method and system for inspection of rotational components based on video frames having different camera views of defects on rotational components. Using optical flow to ascertain motion vectors of pixels of the video frames, the video frames are partitioned based on motion vectors. The partitioned regions are paired with corresponding regions in a subsequent video frame, and their features are matched. For video frames having at least camera motion, a transformation matrix is ascertained which is applied to map defect trajectories of each camera view to a subsequent camera view.

Abstract

An epidermal biosensor (10) is provided. The epidermal biosensor (10) includes a diffusion layer (12) operable to dissolve a solid-phase epidermal analyte, an enzymatic bioreceptor (14) operable to oxidise the dissolved epidermal analyte from the diffusion layer (12), a transducer (16) having an interface with the diffusion layer (12), a processor (18) configured to process electrochemical data from the transducer (16), and a substrate (20) to which the enzymatic bioreceptor (14) and the transducer (16) are attached.

Abstract

According to embodiments of the present invention, an optical sensor is provided. The optical sensor includes a single piece of optical fiber including a modified fiber tip and a distal end opposite to the modified fiber tip. The distal end may be configured to optically communicate with an external light source and an external detector. The modified fiber tip may be configured to be positioned within a turbid medium to deliver light from the external light source to particles in the turbid medium, at least minimize the light being back reflected at the modified fiber tip and receive backscattered light from the particles for determining a real-time fluid property of the particles in the turbid medium by the external detector. According to further embodiments of the present invention, an optical apparatus, an optical arrangement, and a method for determining a real-time fluid property of the particles are also provided.

IPC Classes  ?

• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 21/85 - Investigating moving fluids or granular solids
• G02B 6/02 - Optical fibres with cladding
• A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Abstract

There is provided a bioink for bioprinting a porous three-dimensional hydrogel structure, the bioink comprising an aqueous medium; and granular crosslinkable hydrogel precursor particles suspended in the aqueous medium, wherein the granular crosslinkable hydrogel precursor particles have an average size of from 100 microns to 500 microns, and wherein under suitable crosslinking conditions, the granular crosslinkable hydrogel precursor particles crosslink and adhere to one another, to form the porous three-dimensional hydrogel structure having pore diameters in the range of from 20 microns to 200 microns. There is also provided a method of forming a porous three-dimensional hydrogel structure using the bioink disclosed herein and a porous three-dimensional hydrogel structure obtained from said method.

Abstract

There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber; a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.

Abstract

There is provided an array antenna and a method of generating circularly polarized beams using an array antenna, the array antenna comprising, a plurality of sub-arrays, each of the plurality of sub-arrays comprising, a plurality of antenna elements, each antenna element comprising a first feeding port and a second feeding port; a physical integrated circuit (IC) comprising a plurality of first and second output channels; a first feeding network comprising a plurality of first feed lines communicatively coupling each of the first output channels of the physical IC to a first feeding port of each of the plurality of antenna elements; and a second feeding network comprising a plurality of second feed lines communicatively coupling each of the second output channels of the physical IC to a second feeding port of each of the plurality of antenna elements; wherein the physical IC is configured to excite the plurality of antenna elements via the first feeding network to generate a first circularly polarized (CP) beam and to excite the plurality of antenna elements via the second feeding network to generate a second CP beam, and wherein the respective first CP beams from each of the plurality of sub-arrays form a first combined CP beam; and the respective second CP beams from each of the plurality of sub-arrays form a second combined CP beam.

Abstract

The present invention relates to host cells comprising genes of the mevalonate and Nudix pathways, engineered fusion proteins of enzymes of the mevalonate and Nudix pathways, methods as well as kits for producing geraniol and geranyl acetate.

Abstract

A semiconductor package for flip chip integration is described. In an embodiment, the semiconductor package 100 comprises an assembly 104 and a casing 118. The assembly 104 comprises: a first semi conductor die comprising a first semi conductor layer having one or more first devices on a front side and a first conductive layer 114 electrically connected to the one or more first devices on a back side; a first buffer 110 formed on the back side to electrically and thermally connect the first conductive layer 114 to an electrical contact 126 on the substrate 102; an insulating mold 108 adapted to encapsulate the first semiconductor die 106 and the first buffer 110 apart from a portion of a back surface of the first buffer 110 and a front surface of the first semiconductor die 106; and one or more redistribution layers 112 formed at the front surface to electrically connect the one or more first devices to one or more first electrical connections on a substrate 102. The casing 118 is adapted to electrically and thermally connect the first buffer 110 to the electrical contact 126, wherein the casing 118 is configured to at least partially enclose the assembly 104. Embodiments in relation to a method for forming the semiconductor package is also described.

Abstract

The present invention relates to host cells comprising genes of the mevalonate, lycopene and α-ionone pathways and the hydroperoxide reductase or catalase genes. The present invention also relates to methods of producing apocarotenoids as well as kits for producing apocarotenoids comprising the host cells.

Abstract

Method and systems for defect detection in images by processing the target image using a reinforcement learning agent (RL agent) provided in a memory accessible to the processor to identify a coarse defect region in the target image, processing each coarse defect region using an object detection model (OD model) provided in the memory to identify a sub-region of the coarse defect region corresponding to a defect; wherein the OD model is trained using a low-resolution image dataset; and the RL agent is trained using a high-resolution image dataset.

Abstract

Various embodiments may relate to an acoustic transducer. The acoustic transducer may include a substrate including a cavity extending from a surface of the substrate, wherein the substrate further includes one or more acoustic channels, each of the one or more acoustic channels having a depth extending form the surface of the substrate and a length, the length greater than the depth, extending at least partially around the cavity. The acoustic transducer may also include a layered arrangement suspended over the cavity. The one or more acoustic channels may be configured to include an acoustic medium having a specific acoustic impedance lower than a specific acoustic impedance of the substrate.

Abstract

A computer-implemented method (10) for determining depth and location of localised thinning in a plate structure is provided. The computer-implemented method (10) for determining depth and location of localised thinning in the plate structure includes executing on one or more processors the steps of: selecting (12) a high-order symmetric Lamb wave mode; generating (14) the selected high-order symmetric Lamb wave mode in the plate structure using one or more first ultrasonic transducers attached to the plate structure; detecting (16) the generated high-order symmetric Lamb wave mode using the 0 one or more first ultrasonic transducers or one or more second ultrasonic transducers attached to the plate structure; comparing (18) arrival times of the detected high-order symmetric Lamb wave mode with a set of baseline signals to determine the depth of the localised thinning in the plate structure; and analysing (20) the arrival times of the detected high-order symmetric Lamb wave mode reflected from an edge of the localised thinning to determine the location of the localised thinning in the plate structure.

Abstract

The present invention relates to host cells comprising genes of the mevalonate and linalool pathways, methods as well as kits for producing linalool.

Abstract

The invention relates generally to the field of virology. In particular, the invention is directed to a co-culture system, and a method of screening for at least one agent against HBV infection using the co-culture system.

Abstract

In some aspects, a computer-implemented method using a chameleon hash function is provided. The chameleon hash function includes one or more modular exponentiations and one or more modular multiplications. The method includes, at a signature-verification phase: precomputing, at an offline phase of the signature-verification phase, at least partially each of the one or more modular exponentiations of the chameleon hash function; and evaluating, at an online phase of the signature-verification phase, the chameleon hash function based on the precomputed one or more modular exponentiations and one or more modular multiplications.

Abstract

There is provided a composition comprising at least one epoxy precursor, at least one cross-linker, at least one chain extender, and an electrolyte, wherein the at least one epoxy precursor comprises at least three glycidyl groups per molecule. There are also provided a composite material, a method of forming the same and a capacitor comprising the same.

Abstract

The present invention relates to the use of a compound of formula (I): to extend the chronological lifespan of a cell, a. method for extending the chronological lifespan of a cell, the compound for use in extending the chronological lifespan of a cell and the use of the compound in the manufacture of a. medicament for extending the chronological lifespan of a cell.

Abstract

An ultrasonic transducer (10, 12) for structural health monitoring, a method (200) for producing an ultrasonic transducer (10, 12) for structural health monitoring, and a method (300) for structural health monitoring are provided. The ultrasonic transducer (10, 12) includes a piezoelectric film (14), a first electrode (16) on a first surface of the piezoelectric film (14), and a second electrode on a second surface of the piezoelectric film (14). The piezoelectric film (14) includes polylactic acid having aligned molecular chain orientation.

Abstract

The present invention refers to a method for high-throughput screening of viability of cells, the method comprising the steps of: a) treating, in a well of a first multi-well plate, a sample containing cells with a condition that modulates lifespan; b) transferring a portion of the cells in the well of the first multi-well plate into a well of a second multi-well plate; c) mixing, in a well of the second multi-well plate, the portion of cells with a fluorescent viability dye to stain the cells; d) measuring fluorescence intensity of the stained cells in a plate reader to obtain a fluorescence intensity value; e) measuring optical density of the cells in the plate reader to obtain an optical density value; and f) normalizing the fluorescence intensity value with the optical density value, wherein the normalized fluorescence intensity value directly correlates with the viability of the cells.

Abstract

The present invention relates generally to the field of molecular biology. In particular, the specification teaches methods of preventing or treating an RNA viral infection in a subject, comprising administering at a dose of 5x1011 to 5x1013 vgs/kg of a recombinant adeno-associated virus (AAV) to the subject, wherein the AAV comprises at least one heterologous nucleic acid sequence encoding a Cast 3 nuclease and one or more guide RNAs. In one embodiment, the RNA virus infection is an infection by Enterovirus 71.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 31/14 - Antivirals for RNA viruses

Abstract

There is provided a method of forming a catalyst precursor, including the steps of: (a) forming a precipitate from a slurry, wherein the slurry comprises (i) a mixture of an iron precursor, at least one promotor precursor and a solvent and (ii) a solution of an alkali base; and (b) calcining the precipitate to form the catalyst precursor. There is also provided a catalyst precursor; a method of forming a catalyst; and a catalyst.

IPC Classes  ?

• B01J 27/22 - Carbides
• B01J 23/745 - Iron
• B01J 23/08 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of gallium, indium or thallium
• B01J 23/04 - Alkali metals
• B01J 23/75 - Cobalt
• B01J 27/224 - Silicon carbide
• B01J 37/03 - Precipitation; Co-precipitation
• B01J 37/18 - Reducing with gases containing free hydrogen
• B01J 37/08 - Heat treatment
• C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen

Abstract

Disclosed herein is a process for solubilizing a protein comprising the step of subjecting a dispersion of an untreated protein to a pressure in the range of 250 MPa to 650 MPa and a pH in the range of 1 to 3 or 9 to 14 to solubilize the untreated protein to form the solubilized protein. Disclosed herein is also a process of forming a food composition from the solubilized protein as described herein.

Abstract

Described herein is a method of imaging an inanimate structural implant in a tissue. The method includes positioning a magnetic particle imaging device proximal to the inanimate structural implant in the tissue, the inanimate structural implant coupled to at least one magnetic particle; exciting the at least one magnetic particle with a generated magnetic field from the magnetic particle imaging device; receiving a signal from the excited at least one magnetic particle; and constructing an image of the inanimate structural implant based on the signal. A method of heating an inanimate structural implant is also described, the method includes positioning a device proximal to the inanimate structural implant in the tissue, the device configured to generate alternating magnetic fields, the inanimate structural implant coupled to at least one magnetic particle; generating alternating magnetic fields with the device; and heating the inanimate structural implant with the generated alternating magnetic fields.

Abstract

Describe herein is a polyolefin composite and a method of preparation. The method includes blending a mixture comprising 50 to 94.9 weight percent (wt%) of a matrix polymer, 5 to 40 wt% of a reinforcement polymer; and 1 to 20 wt% of a crosslinked molecule and/or 0.1 to 10 wt% of a nanofiller to provide a blended mixture, wherein the weight percent of each component is with respect to the polyolefin composite; and forming the polyolefin composite from the blended mixture, wherein the matrix polymer is a first polyolefin with a number average molecular weight of at most 300,000, and the reinforcement polymer is a second polyolefin with a number average molecular weight of at least 1,500,000. The polyolefin composite includes the matrix polymer, the reinforcement polymer, and the crosslinked molecule and/or the nanofiller as described aforementioned.

IPC Classes  ?

• C08L 23/06 - Polyethene
• C08K 3/013 - Fillers, pigments or reinforcing additives
• D01F 6/46 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyolefins
• D01F 1/10 - Other agents for modifying properties

Abstract

invitrovitro 3D intestinal epithelial tissue model; (ii) dissociating tissues of the 3D intestinal epithelial tissue model into a single cell suspension culture; (iii) fixing cells of the single cell suspension culture with a fixative; and (iv) measuring a proportion of cells having micronuclei (MN) in the cells from step (iii) and measuring a proportion of cells having micronuclei in a control population of cells not exposed to the test compound, wherein an elevated proportion of cells from step (iii) having micronuclei relative to the control population of cells indicates that the test compound is genotoxic.

Abstract

The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method. Finally, the present invention also refers to an in vivo method of detecting the survival rate of a retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in a subject and an in vitro method of determining the immunogenicity of said retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in said subject, to whom said differentiated RPE cell has been pre-delivered.

Abstract

There is provided a convolution engine configured to perform neural network computations. The convolution engine including: a plurality of convolution processing blocks, each convolution processing block being configured to perform convolution based on a 2D array of first feature map data stored therein to produce a set of first convolution outputs, each set of first convolution outputs including a plurality of channels; and a plurality of weight memory blocks communicatively coupled to the convolution processing blocks. Each weight memory block is configured to store and supply weight parameters to the corresponding convolution processing blocks to perform convolution. Each convolution processing block further comprises a plurality of processing element blocks and each processing element block can further comprise a plurality of sub-blocks and corresponding weight memory sub-blocks.

IPC Classes  ?

• G06F 17/15 - Correlation function computation
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Herein disclosed is an ex vivo method of identifying a state of a tumor margin in a sample. The method comprises operating a system to generate an ultrasound image and a photoacoustic image, wherein the system comprises: a probe configured to deliver a pulsed laser from a laser source to a sample, wherein the laser source is operable to generate the pulsed laser; arrays coupled to the probe, wherein one of the arrays comprises transducing elements arranged thereon which are operable to transmit and collect ultrasound signals, and wherein one of the arrays comprises transducing elements arranged thereon which are operable to collect photoacoustic signals; and a data acquisition module which converts the ultrasound signals and the photoacoustic signals into the ultrasound image and the photoacoustic image, respectively, identifying from the photoacoustic image the presence or absence of lipids and observing for a pattern and distribution of the lipids, identifying from the photoacoustic image the presence or absence of collagen and observing for a pattern and distribution of the collagen; identifying from the photoacoustic image the presence or absence of hemoglobin and observing for a pattern and distribution of the hemoglobin; and comparing from the photoacoustic image an intensity of the collagen and/or hemoglobin, if present, with an intensity of tissue proximal to the collagen and/or hemoglobin. Herein disclosed is a method of determining a state of a tumor.

IPC Classes  ?

• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The present invention relates generally to genomics. In particular, the specification teaches a method of predicting subjects at risk of rheumatoid arthritis and the responsiveness of a subject towards methotrexate (MTX) treatment.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

The present invention relates to a core-shell capsule comprising maslinic acid embedded in a hydrophobic core comprising a polysorbate with a polyethylene glycol (PEG) moiety, cross-linked with a polyacid or a salt of polyacid to provide a polyethylene glycol-containing hydrophilic shell surrounding the hydrophobic core.

IPC Classes  ?

• C07J 63/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
• A61K 9/50 - Microcapsules
• A61K 8/90 - Block copolymers

Abstract

This technology relates to the production of lactose and human milk oligosaccharides (HMOs) in cells.

Abstract

An Advanced Encryption Standard (AES) cryptographic system and a method of performing Advanced Encryption Standard (AES) cryptography. The method comprises the steps of performing multiplicative inversion for SubBytes transformation using two forward-reverse linear-feedback shift registers, LFSRs, pairs; and using different respective initialization seeds for the pairs of forward-reverse LFSRs.

IPC Classes  ?

• H04L 9/06 - Arrangements for secret or secure communications; Network security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• G06F 7/58 - Random or pseudo-random number generators

Abstract

A decoder for decoding a codeword of a Tunstall code is provided, including: a sub-decoder configured to receive an input codeword of the Tunstall code to the decoder and output a decoded symbol of the input codeword; a symbol memory configured to receive and store the decoded symbol of the input codeword from the sub-decoder; and a controller configured to control the symbol memory to output one or more decoded symbols stored in the symbol memory. The sub-decoder includes: a node memory configured to store, for a plurality of nodes of a Tunstall tree of the Tunstall code corresponding to a first level of the Tunstall tree, a plurality of codewords of the Tunstall code assigned to the plurality of nodes, respectively; and a comparator configured to compare the input codeword with the plurality of codewords assigned to the plurality of nodes corresponding to the first level of the Tunstall tree received from the node memory and produce the decoded symbol of the input codeword with respect to the first level of the Tunstall tree based on the comparison. Another decoder for decoding a codeword of a Tunstall code is also provided, including: a symbol memory comprising a plurality of memory entries, each memory entry having stored therein one or more decoded symbols of a codeword of the Tunstall code corresponding to the memory entry; and a controller configured to receive an input codeword of the Tunstall code to the decoder and control the symbol memory to output the one or more decoded symbols stored in one of the plurality of memory entries corresponding to the input codeword.

IPC Classes  ?

• H03M 7/30 - Compression; Expansion; Suppression of unnecessary data, e.g. redundancy reduction
• H03M 7/26 - Conversion to or from stochastic codes
• G06N 3/02 - Neural networks

Abstract

Disclosed are p53 peptidomimetic macrocycles, each p53 peptidomimetic macrocycle comprising an i, i + 4 olefin staple and a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; an i, i + 7 olefin staple and a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; or, an i, i + 7 di-alkyne staple and optionally a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; wherein the p53 peptidomimetic macrocycle comprises all D-configuration amino acids and the polypeptide tail comprises three to nine amino acids, each amino acid of the polypeptide tail independently having a D-configuration or an L-configuration. The p53 peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX, thereby antagonizing MDM2 and MDMX binding to p53. These p53 peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

IPC Classes  ?

• C07K 7/52 - Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
• A61K 38/12 - Cyclic peptides
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• A61K 38/10 - Peptides having 12 to 20 amino acids
• C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Abstract

A neurosynaptic core and a method of operating a neurosynaptic core with improved fanout limits. The method comprises the steps of generating an output spike form a neuronal circuit; processing the output spike from the neuronal circuit to generate a first group of multicast spikes for sending via a network interface; processing the output spike from the neuronal circuit to generate an internal multicast request; processing the internal multicast request to generate a second group of multicast spikes for sending via the network interface; processing the output spike or the internal multicast request to generate a multicast request for sending via the network interface; and processing a multicast request received from another neurosynaptic core via the network interface to generate a third group of multicast spikes for sending via the network interface.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

There is provided a method of oxidizing a saturated carbon atom of a polyolefin backbone, the method comprising: providing i) a polyolefin comprising the polyolefin backbone and ii) a metal catalyst; adding a peroxycarboxylic acid; and allowing an oxidation reaction to occur of the saturated carbon atom of the polyolefin for obtaining a modified polyolefin having hydroxy, keto and halo substituents on its polyolefin backbone; wherein the oxidation reaction is carried out substantially without dilution in a solvent. There is also provided a modified polyolefin obtained from the method.

IPC Classes  ?

• C08F 8/06 - Oxidation
• C08L 23/30 - Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by oxidation
• C08F 10/00 - Homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
• C08F 255/02 - Macromolecular compounds obtained by polymerising monomers on to polymers of hydrocarbons as defined in group on to polymers of olefins having two or three carbon atoms

Abstract

There is provided a genetically modified cell wherein at least one gene has been deleted from the cell and the gene is selected from the group consisting of p50, p52, p65, c-Rel, and RelB. Also disclosed are methods of identifying a target for treating acute myeloid leukemia (AML) in a subject, methods of treating acute myeloid leukemia (AML) in a subject in need thereof, comprising inhibiting the activity of an NF-KB pathway. Also provided is an ATP13A2 inhibiting agent for use in therapy or medicine, for use in treating AML, and in the manufacture of a medicament for treating AML.

IPC Classes  ?

• C12N 5/16 - Animal cells
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Various embodiments may relate to a method of forming a silicon carbide epitaxial wafer. The method may include providing a silicon carbide substrate with a predetermined negative substrate bow, and forming a silicon carbide epitaxial layer on a front surface of the silicon carbide substrate.

IPC Classes  ?

• H01L 21/20 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth
• C30B 29/36 - Carbides
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

There is provided a method of sorting and / or characterising a heterogenous macrophage population into subpopulations wherein the method comprises clustering the heterogenous population into subpopulations based on their gene expressions, wherein the subpopulations comprise one or more of: Disease Inflammatory Macrophage (DIM), dysregulated microglia, Disease Associated Microglia (DAM), microglia, border-associated macrophages (BAMs), MHCII- BAMs, MHCII+ BAMs, and CD11a+ cells. Also provided is a method of diagnosing a condition in a subject, a method of evaluating progression of a condition in a subject, a method of distinguishing DIM from DAM, a method of treating a condition, and a method of screening for an agent / composition for treating a condition.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

According to embodiments of the present invention, a sweat sensing device is provided. The sweat sensing device includes a continuous piece of hydrophilic paper including a first region for receiving sweat, a second region opposite the first region, and a third region therebetween; a flexible hydrophobic film having an opening; and a sensor unit. The hydrophobic film and the hydrophilic paper are arranged adjacent to each other with the opening aligned to and exposing the second region. The sensor unit is configured to facilitate a measurement based on the diffused sweat. The hydrophobic film and the hydrophilic paper are collectively folded in a stacked manner such that the sensor unit is sandwiched between the third and second regions. The hydrophilic paper is adapted for the received sweat to diffuse laterally along the hydrophilic paper. According to further embodiments, a method for forming the sweat sensing device is also provided.

IPC Classes  ?

• G01N 33/487 - Physical analysis of biological material of liquid biological material
• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value

Abstract

The invention relates to nucleic acids encoding dominant negative polypeptides comprising the a3 helix of CC2 region and the SUN domain of a SUN domain-containing protein that inhibit the LING complex. The specific embodiment relates to polypeptides of varying lengths derived from amino acids 404-812 of SUN1 with a KDEL signal sequence. It also relates to methods of identifying a LING complex inhibitor and the use of said polypeptides for treating and preventing laminopathies, and diseases characterised by hyperlipidaemia.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• A61K 38/16 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• A61P 3/06 - Antihyperlipidemics
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

Herein disclosed is a flame retardant synergist comprising a repeating unit comprising a backbone represented by a formula of: wherein moiety A is derived from a substituted triazine having at least two amino groups, wherein moiety B is derived from a dialdehyde having a terminal aldehyde, wherein moiety A and moiety B are bonded via a -C-N- linkage formed from having one of the at least two amino groups reacted with the terminal aldehyde, wherein n ranges from 5 to 1000, and one or more side units extending from the backbone, wherein the one or more side units are derived from 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide or a derivative thereof. A flame retardant polymer composite comprising a polymer, the flame retardant synergist, and a flame retardant additive, is also disclosed herein. Methods of forming the flame retardant synergist and the flame retardant polymer composite are further disclosed herein.

IPC Classes  ?

• C08G 12/30 - Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with heterocyclic compounds with substituted triazines
• C08G 12/40 - Chemically modified polycondensates
• C09K 21/14 - Macromolecular materials
• C08L 79/04 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors

Abstract

Method and system for detecting a lane are provided herein. In an embodiment, the method comprises: receiving one or more source detecting images captured by an image capturing device (102) at step S302, the or each of the source detecting images including a source road region having lane features; generating a translated source image corresponding to each of the one or more source detecting images by using a lane feature enhancement module (122) at step S304, with the lane features of the source road region being enhanced in the translated source image; and detecting the lane from the translated source image at S306; wherein the lane feature enhancement module (122) is trained by a plurality of training images and comprises a generator network, to: identify a road region (136) of a corresponding training image of the plurality of training images, translate the road region (136) of the corresponding training image to a translated road region to minimize a loss function that quantifies a dissimilarity between the road region (136) and the translated road region to generate the translated source image. A method of training the lane feature enhancement module (122) is also disclosed.

IPC Classes  ?

• G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
• G06F 18/24 - Classification techniques
• G06N 20/00 - Machine learning
• B60W 30/12 - Lane keeping
• G08G 1/16 - Anti-collision systems

Abstract

Embodiments of the invention provide for a multimodal microscopy system. The multimodal microscopy system may include an illumination module configured to provide a light beam to a sample under test via a delivery path; and an optical arrangement configured to receive the light beam from the sample through a detection path to generate a microscopy image of the sample. The optical arrangement may be operable to switch among a plurality of imaging modalities using the detection path shared by the plurality of imaging modalities. The plurality of imaging modalities may include brightfield microscopy, fluorescent microscopy, and endoscopic microscopy. The multimodal microscopy system may be a multimodal hyperspectral microscopy system.

IPC Classes  ?

• G02B 21/00 - Microscopes
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

The present invention relates generally to the field of biotechnology. In particular, the invention relates to methods of using aptamer or antibody to detect for the presence of Vibrio spp. in a sample.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C -terminal tail. These crosslinked peptidomimetic macrocycles have improved binding to MDM2 and MDMX (aka MDM4), are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

IPC Classes  ?

• C07K 4/00 - Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
• A61K 38/03 - Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
• A61P 35/00 - Antineoplastic agents
• A61K 38/12 - Cyclic peptides
• C07K 7/64 - Cyclic peptides containing only normal peptide links

Abstract

The present invention relates to an inhalable dry powder formulation comprising a recombinant alpha-1-antitrypsin protein, a force control agent comprising di-leucine and tri-leucine in combination thereof, wherein the force control agent is present in an amount of at least 50% by weight of the formulation, and pharmaceutically acceptable excipients including a sodium salt and a non-reducing sugar or a sugar alcohol or a combination thereof.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 38/57 - Protease inhibitors from humans
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

A beamforming transmission system and a method of controlling an output power of a beamforming transmission system are disclosed, the system comprising one or more transmission elements, the one or more transmission elements each comprising a power amplifier; an antenna coupled to the power amplifier; and a power detector coupled to the antenna; a power controller coupled to the power amplifier; a system processing module coupled to the one or more transmission elements, the system processing module further coupled to the power controller, the system processing module being arranged to instruct the power controller to control an output power of the power amplifier; wherein the system processing module is arranged to determine a desired beam scanning angle of the one or more transmission elements and to obtain a present output power of the power amplifier from the power detector; and further wherein the system processing module is arranged to instruct the power controller to control the output power of the power amplifier based on both the desired beam scanning angle and the present output power of the power amplifier.

IPC Classes  ?

• H04B 1/04 - Circuits
• H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The present invention relates to a salt-based antifungal powder platform formulation comprising a sodium salt and L-leucine as excipients to be formulated alongside an antifungal agent to obtain a salt-based antifungal powder formulation, wherein the sodium salt is at a concentration of 5% w/w or less and the L-leucine is at a concentration of 30% w/w.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/10 - Antimycotics

Abstract

A catalyst, a catalyst synthesis method (10) and a catalytic plastic conversion method (50) are provided. The catalyst includes a single metal oxide on a catalyst support. 5 The catalyst synthesis method (10) includes dissolving (12) a single metal precursor in deionised water to form a precursor-containing solution, mixing (14) a catalyst support into the precursor-containing solution to impregnate the catalyst support with the precursor-containing solution, drying (18) the impregnated catalyst support, and calcining (20) the dried impregnated catalyst support to form a supported single metal oxide catalyst.

IPC Classes  ?

• B01J 23/745 - Iron
• B01J 23/755 - Nickel
• B01J 21/04 - Alumina
• B01J 21/08 - Silica
• B01J 21/10 - Magnesium; Oxides or hydroxides thereof
• C01B 32/162 - Preparation characterised by catalysts

Abstract

Disclosed are optical detection device, system, and method which increase photodetection area and enables omnidirectional and self-aligning photodetection through the use of a fluorescent lens. An optical detection device comprises a fluorescent lens having a light collecting area being a spherical, hemispherical, or cylindrical surface of the fluorescent lens, and a light outcoupling area; and a fluorophore dispersed throughout the light collection area and the fluorescent lens, wherein the fluorophore is excitable by a light beam, which is incident at any position or angle in relation to the spherical surface, to produce a light emission, wherein the light outcoupling area is arranged to allow an extraction of the light emission from the fluorescent lens, wherein the light collecting area is larger than the light outcoupling area.

IPC Classes  ?

• F21V 3/08 - Globes; Bowls; Cover glasses characterised by materials, surface treatments or coatings characterised by the material the material comprising photoluminescent substances
• F21V 5/10 - Refractors for light sources comprising photoluminescent material
• G02B 6/00 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
• G01N 21/64 - Fluorescence; Phosphorescence
• F21V 5/04 - Refractors for light sources of lens shape

Abstract

The Invention relates to methods and compositions for Inhibiting telomerase activity In cells. In an aspect of the present Invention, there Is provided a use of a moiety that inhibits MED12 in the manufacture of a medicament for treating cancer. In another aspect of the present invention, there is provided a method for inhibiting telomerase activity in a cell comprising a mutant hTERT promoter, the method comprising contacting the cell with an inhibitor of MED12.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

Spray-dried Compositions and Methods of Preparation Spray-dried compositions that may be used in food products, the methods of preparing the compositions and food products containing the compositions are described. The spray-dried composition contains 5 to 50 weight percent (wt. %) of a prebiotic, 10 to 65 wt.% of a probiotic, and 30 to 80 wt. % of a coating material. The prebiotic may be a polysaccharide, an oligosaccharide, a polyol, whey protein, and any combinations thereof. The probiotic may be Lacticaseibacillus, Lactobacillus, Lactiplantibacillus, Levilactobacillus, Ligilactobacillus, Limosilactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Pediococcus, Leuconostoc, Bacillus, Escherichia, Saccharomyces, and any combinations thereof. The coating material may be a synthetic polymer, a natural polymer, and any combinations thereof. The spray-dried compositions are prepared by providing at least one solution containing the composition components and spray drying the at least one solution.

IPC Classes  ?

• A23P 10/30 - Encapsulation of particles, e.g. foodstuff additives
• A23L 29/00 - Foods or foodstuffs containing additives; Preparation or treatment thereof
• A23P 20/18 - Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23L 3/46 - Spray-drying

Abstract

There is provided a method for preparing a polymer having ester functionality in the backbone of the polymer, the method comprising a step of reacting a mixture of monomers that comprises: (i) at least one first acrylate and/or methacrylate monomer; (ii) at least one cyclic ketene acetal monomer; and (iii) at least one additional monomer selected from the group consisting of a second acrylate and/or methacrylate monomer that is functionalized with hydrophilic groups, a vinylic monomer that is functionalized with hydrophilic groups, and combinations thereof in aqueous media to obtain the polymer. There is also provided a polymer having ester functionality in the backbone of the polymer obtained from said method.

IPC Classes  ?

• C08F 216/38 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical by an acetal or ketal radical
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08G 63/00 - Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
• C08G 63/81 - Preparation processes using solvents
• C08F 2/30 - Emulsion polymerisation with the aid of emulsifying agents non-ionic

Abstract

There is provided a system and a method of non-contact measurement of one or more mechanical properties of a material, the system comprising an ultrasonic module comprising an ultrasonic applicator configured to apply ultrasonic pressure on a target region of the material; a detection module comprising an electromagnetic wave emitter and an electromagnetic wave detector, said electromagnetic wave emitter being configured to emit an incident beam of electromagnetic waves towards the target region of the material, and said electromagnetic wave detector being configured to detect an emergent beam of electromagnetic waves reflected from the target region and/or transmitted through the target region; and a processing module configured to determine one or more measures corresponding to the one or more mechanical properties of the material, based on changes in the emergent beam of electromagnetic waves.

IPC Classes  ?

• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

An external illuminator for a microscope, a microscope, and a microscopy method is described. The external illuminator includes a light source; at least one optical fibre optically coupled to the light source, the at least one optical fibre configured to deliver and direct light from the light source along an illumination path to a sample being observed through an objective lens of the microscope, the objective lens having a working distance of 2mm or less; and an adjustment module couplable to a portion of the microscope and arranged to support the at least one optical fibre, wherein the adjustment module is configured to adjust the at least one optical fibre spatially and/or angularly relative to the objective lens in a manner such that the illumination path is separate from a detection path of the objective lens, and the objective lens is movable to the working distance of the objective lens.

IPC Classes  ?

• G02B 21/06 - Means for illuminating specimen
• G02B 21/18 - Arrangements with more than one light-path, e.g. for comparing two specimens

Abstract

The invention relates to recombinant mutated angiotensin converting enzyme 2 (ACE2) comprising one or more amino acid substitutions at amino acid positions T27, F28, K31, H34, Y41 and Q42 which have improved binding affinity to SARS-CoV-1 and/or SARS-CoV-2. It also relates to combinatorial mutant ACE2 comprising T27Y/K31 H/H34A, T27YZ K31 H/H34V and T27Y/K31 Y/H34V and the use of said mutant ACE2 for treating and preventing coronavirus infection.

IPC Classes  ?

• C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
• C12N 15/62 - DNA sequences coding for fusion proteins
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A microfluidic chip for sample preparation and a sample preparation system thereof, wherein the microfluidic chip includes a chip body, a first chamber configured to receive a sample via a first injection port and a reducing agent via a second injection port, a first mixer in fluid communication with the first chamber and operable to mix the sample and a reducing agent from the first chamber to produce a denatured and reduced sample, a second chamber in fluid communication with the first mixer and configured to receive an alkylating agent via a third injection port, a second mixer in fluid communication with the second chamber and operable to mix the denatured and reduced sample with an alkylating agent to produce an alkylated sample, a third chamber in fluid communication with the second mixer and configured to receive a protein precipitation solution via a fourth injection port, a third mixer in fluid communication with the third chamber and operable to mix the alkylated sample with the protein precipitation solution to produce a precipitated sample, a reaction chamber in fluid communication with the third mixer and configured to receive a washing buffer via a fifth injection port, a digestion buffer via a sixth injection port and an elution buffer via a seventh injection port, a depth filter received in the reaction chamber, a first discharge port and a second discharge port in fluid communication with the reaction chamber.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• C07K 1/36 - Extraction; Separation; Purification by a combination of two or more processes of different types
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

Several cell-permeable macrocyclic peptides that bind eIF4E on the cap-binding site via its "apo" form rather than its "closed" form which small molecules prefer, have been designed. These macrocyclic peptides were observed to effectively serve as m7GTP mimics, which inhibit eIF4E by preventing its phosphorylation, thus attenuating the translation of 'eIF4E-sensitive mRNAs' into proteins involved in the oncogenic pathways.

IPC Classes  ?

• C07K 7/50 - Cyclic peptides containing at least one abnormal peptide link
• A61P 35/00 - Antineoplastic agents
• A61K 38/12 - Cyclic peptides

Abstract

Herein disclosed is a portable device operable to identify photosynthetic activity and contents of compounds in a plant part, the portable device may comprise: a light source comprising light-emitting diodes operable to irradiate the plant part with light comprising more than one wavelength; a control module operable to (i) have the light-emitting diodes emit the light as pulse signals and (ii) modulate amplitude and width of the pulse signals; a focus-adjustable lens and a filter optically coupled to the light source, wherein the adjustable lens and the filter are co-operable to consolidate light reflected from the plant part which may be irradiated by light from the light-emitting diodes; and a detector optically positioned to receive from the focus-adjustable lens and the filter the light reflected from the plant part, wherein the light reflected from the plant part corresponds to the photosynthetic activity and contents of compounds in the plant part, and the light reflected is transmitted as fluorescence. A method of identifying photosynthetic activity and contents of compounds in a plant part using the portable device is also disclosed herein.

IPC Classes  ?

• G01J 3/46 - Measurement of colour; Colour measuring devices, e.g. colorimeters
• G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/84 - Systems specially adapted for particular applications
• A01G 7/04 - Electric or magnetic treatment of plants for promoting growth
• G01J 3/00 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

There is provided a method of coating a gel particle, the method comprising heterocoagulating nanoparticles onto a gel microparticle to form a coating layer over the gel microparticle. Also provided is a coated gel particle comprising a gel microparticle; and a coating layer over the gel microparticle, wherein said coating layer comprises a heterocoagulated form of nanoparticles on the gel microparticle.

IPC Classes  ?

• C08J 7/04 - Coating
• B01J 13/10 - Complex coacervation, i.e. interaction of oppositely charged particles
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• C01B 33/14 - Colloidal silica, e.g. dispersions, gels, sols
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Abstract

Provided herein is a copolymeric material comprising one or more random copolymers having have a number average molecular weight of from 800 to 10,000 Daltons, where each of the one or more copolymers comprises each of a constitutional unit derived from caprolactone, a constitutional unit derived from polyethylene glycol and a constitutional unit derived from oxalic acid, where each of the constitutional units are connected via an ester linkage. The copolymers may comprise acrylate capping units, and such copolymers may be useful as an additive in a gel nail polish formulation, whereby a gel nail polish prepared using said formulation may be removed from a user's nail by ultrasonic irradiation.

IPC Classes  ?

• C08G 63/08 - Lactones or lactides
• C08G 63/16 - Dicarboxylic acids and dihydroxy compounds
• C08G 63/672 - Dicarboxylic acids and dihydroxy compounds
• C08G 63/91 - Polymers modified by chemical after-treatment
• C08L 67/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08L 67/07 - Unsaturated polyesters having terminal carbon-to-carbon unsaturated bonds
• A61K 8/85 - Polyesters
• A61Q 3/02 - Nail coatings

Abstract

There is provided a method of programming a synaptic memory array of a neural processing core configured to perform neural network computations for a neural network. The method includes: writing an intended synaptic weight value for a group of synaptic memory cells of the synaptic memory array to a first synaptic memory cell of the group of synaptic memory cells of the synaptic memory array; obtaining a first residual synaptic weight value associated with the group of synaptic memory cells based on the intended synaptic weight value and an obtained first synaptic weight value of the group of synaptic memory cells, the obtained first synaptic weight value being obtained based on a written state value of the first synaptic memory cell from the above-mentioned writing the intended synaptic weight value to the first synaptic memory cell; and writing a first intended residual synaptic weight value determined based on the obtained first residual synaptic weight value to a second synaptic memory cell of the group of synaptic memory cells, the second synaptic memory cell being immediately succeeding the first synaptic memory cell in the group of synaptic memory cells. There is also provided a corresponding neural processing core and a corresponding method of performing neural network inference thereon.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron

Abstract

Herein discloses a flame retardant polyamide composite comprising a polyamide, a synergist, wherein the synergist comprises a polymer having a backbone and a side unit of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide bonded thereto, wherein the backbone of the polymer comprises at least one heterocyclic moiety, and a flame retardant agent, wherein the synergist and the flame retardant agent are present in an amount ranging from more than 0 to 10 wt%. Herein also discloses a method of forming the flame retardant polyamide composite, the method comprising cryogenic milling a synergist, mixing the synergist with a flame retardant agent to obtain a mixture, and compounding the mixture with a polyamide to obtain the flame retardant polyamide composite. No suitable figure to be published with abstract

IPC Classes  ?

• C08G 79/04 - Phosphorus linked to oxygen or to oxygen and carbon
• C08L 85/02 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon; Compositions of derivatives of such polymers containing phosphorus
• C08L 77/00 - Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
• C09K 21/14 - Macromolecular materials

Abstract

The present invention relates to a method of encapsulating a water-soluble active compound. The method comprises mixing an aqueous solution comprising a water-soluble active compound with an oil in the presence of a surfactant under high shear condition to form a water-in-oil emulsion; adding an aqueous solution of octenyl succinic anhydride (OSA)-modified starch to the water-in-oil emulsion and homogenizing further to obtain a water-in-oil-in-water double emulsion; and mixing an aqueous solution comprising a cross-linker selected from the group consisting of adipic acid dihydrazide and methylglyoxal with the thus formed double emulsion for cross-linking the OSA- modified starch, thereby forming starch microcapsules with the water-soluble active compound encapsulated within the starch microcapsules.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking
• A23L 29/219 - Chemically modified starch; Reaction or complexation products of starch with other chemicals
• A23L 29/10 - Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
• A23P 10/35 - Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate

Abstract

A method of controlling intensity of visible light, the method comprising: passing visible light through an optical plastic film, the optical plastic film comprising at least one functional surface that interacts with incident visible light to control the intensity of the incident visible light by transmitting 50-90% of the incident visible light without the use of electricity.

IPC Classes  ?

• G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
• A01G 7/04 - Electric or magnetic treatment of plants for promoting growth
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor

Abstract

The present invention relates to a composition comprising a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises one or more active agent physically bound to one or more conjugate, wherein each conjugate comprises one or more flavonoid molecule and a first water-soluble polymer, and the nanocomplex is at least partially encapsulated by a second water-soluble polymer. The present invention also relates to a method of preparing the composition and uses thereof. The present invention also relates to a method of treating an eye disease caused by angiogenesis, comprising administering a composition to a subject in need thereof, wherein the composition comprises a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises an ophthalmic anti-angiogenesis drug physically bound to one or more conjugate, each conjugate comprising one or more flavonoid molecule and a first water- soluble polymer.

IPC Classes  ?

• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 39/44 - Antibodies bound to carriers
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 27/02 - Ophthalmic agents
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A paint thickness measuring device (10) and a computer-implemented method (50) for measuring paint thickness using the same are provided. The paint thickness measuring device (10) includes a first continuous-wave (cw) laser (12), a second continuous-wave laser (14), a photomixer (15), one or more computer processors (22), and a non-transitory computer-readable memory (24). The photomixer (15) includes an optical coupler (26) configured to mix laser lights emitted by the first and second continuous-wave lasers (12, 14) and generate a terahertz (THz) wave, a photomixer emitter (16) configured to emit the terahertz wave, and a photomixer receiver (18) configured to detect the terahertz wave reflected off a painted surface (20). The non-transitory computer-readable memory (24) stores computer program instructions executable by the one or more computer processors (22) to perform operations for paint thickness measurement. The operations include: comparing (52) the detected terahertz wave (54) to simulation results (56), identifying (58) a minimum difference between the detected terahertz wave (54) and the simulation results (56), and determining (60) a paint thickness of the painted surface (20) from the simulation results (56) with the minimum difference.

IPC Classes  ?

• G01B 11/06 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness for measuring thickness
• G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
• G01N 21/55 - Specular reflectivity

Abstract

The present invention relates to the field of cell differentiation. In particular, the invention relates to a method for generating retinal ganglion cells (RGCs), the method comprising the steps of: (a) overexpressing KLF7 in eye field progenitor cells; and (b) culturing the KLF7-overexpressed eye field progenitor cells in a medium under conditions suitable for RGC formation.

IPC Classes  ?

• C12N 5/079 - Neural cells

Abstract

Disclosed is a method for treating a liver disease in a subject comprising administering a Tjp1 inhibitor the subject. The Tjp1 inhibitor may be a siRNA or shRNA that targets Tjp1. Also disclosed are a kit and nucleic acid encoding a Tjp1 inhibitor.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides a method of removing gossypol from one or more plant parts, comprising incubating a mixture of the one or more plant parts with an acidified amino acid solution, wherein amino acid comprises more than one nitrogen-containing functionality. The acidified amino acid solution comprises an acid, an amino acid and a solvent. In an embodiment, the solvent is an organic solvent. In another embodiment, the plant is cotton. In a further embodiment, the amino acid is selected from the group consisting of lysine, arginine, methionine, serine, histidine and mixtures thereof. There is also provided a protein isolate having a total gossypol content of less than 250 ppm.

IPC Classes  ?

• A23L 5/20 - Removal of unwanted matter, e.g. deodorisation or detoxification
• A23K 10/10 - Animal feeding-stuffs obtained by microbiological or biochemical processes
• A23J 1/00 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites

Abstract

There is provided an ion selective membrane comprising a polymer matrix and an ionic lipophilic additive covalently bonded to the polymer matrix. There are also provided a method of preparing the ion selective membrane, an ion selective electrode comprising the ion selective membrane and a method of preparing the ion selective electrode.

IPC Classes  ?

• G01N 27/333 - Ion-selective electrodes or membranes

Abstract

There is provided a method of detecting a population of macrophage in a sample comprising detecting and/or determining the expression of Cdh5 in the macrophage in the sample. Also disclosed is a kit for detecting and/or separating and/or depleting a population of a macrophage, a method of depleting a population of a macrophage, a method of improving the health of an obese and/or overweight subject, a method of determining the risk of obesity and/or a metabolic impairment related to obesity in a subject, and an animal model thereof.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• A01K 67/027 - New breeds of vertebrates

Abstract

There is provided a method of producing a bioactive polymer filament, the method comprising: providing a base polymer powder and a bioactive copolymer; mixing the base polymer powder with the bioactive copolymer to obtain a mixture; and extruding a bioactive polymer filament from the mixture at an extrusion temperature profile that is based on a predetermined melt/softening temperature and a predetermined onset degradation temperature of the bioactive polymer; and performing a post-extrusion thermal analysis on the extruded bioactive polymer filament to assess onset degradation of the bioactive copolymer in the filament. There is also provided a bioactive polymer filament obtained from said method and a fused filament fabrication (FFF) or fused deposition modelling (FDM) based three-dimensional printing method.

IPC Classes  ?

• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• C08L 45/00 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring system; Compositions of derivatives of such polymers
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08F 232/08 - Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings

Abstract

A connector system including a pair of connector components. Each including a connector housing having a mating surface with an opening and a door moveable to close and open the opening, and a connector assembly therein and moveable towards or away from the opening. The connector assembly including a base member having a fluid port; an engagement piece having a pusher portion; and a valve unit therebetween, the valve unit having a resilient deformable valve member. The pusher portion being in abutment with the resilient deformable valve member and moveable to cause the pusher portion to urge open the resilient deformable valve member for enabling the fluid flow. When the pair of connector components are interlocked, the doors open and the connector assemblies move and engage with each other through the openings causing the resilient deformable valve members to open for establishing a fluid connection.

IPC Classes  ?

• A61M 39/16 - Tube connectors or tube couplings having provision for disinfection or sterilisation
• A61M 39/26 - Valves closing automatically on disconnecting the line and opening on reconnection thereof
• F16L 37/35 - Couplings of the quick-acting type with fluid cut-off means with fluid cut-off means in each of two pipe-end fittings at least one of two lift valves being opened automatically when the coupling is applied at least one of the valves having an axial bore communicating with lateral apertures
• F16K 7/20 - Diaphragm cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage with a compressible solid closure member
• A61M 39/00 - Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
• F16L 37/00 - Couplings of the quick-acting type

Abstract

Herein disclosed includes a biocompatible SERS-active polymer membrane configured to detect biomarkers in a sample, comprising: a flexible and porous polymer membrane; and SERS-active nanoparticles formed on the flexible and porous polymer membrane, wherein the flexible and porous polymer membrane comprises cellulose or an elastomeric polymer. Also disclosed herein is a method of forming the biocompatible SERS-active polymer membrane and a method of determining a state of wound healing in a diabetic individual involving the use of the biocompatible SERS-active polymer membrane.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01J 3/44 - Raman spectrometry; Scattering spectrometry
• C23C 14/20 - Metallic material, boron or silicon on organic substrates
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• C08J 7/04 - Coating
• C08L 1/02 - Cellulose; Modified cellulose
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Abstract

Described herein is a hydrogel comprising a peptide and gelatin. The peptide comprises a sequence having at least 8 amino acids with alternating hydrophobic amino acids (X) and hydrophilic amino acids (Y), wherein each hydrophobic amino acid is independently selected from isoleucine (I), valine (V) and leucine (L), each hydrophilic amino acid is independently selected from arginine (R), lysine (K), glutamic acid (E), and aspartic acid (D), wherein the hydrophilic amino acids are selected such that there is at least one arginine and at least one lysine. A kit and method for preparing the hydrogel is described as well. The hydrogel may be used to culture cells and determine an effect of a compound on a cell cultured in the hydrogel.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The disclosure concerns bacterial cell counting devices, systems and methods thereof. The bacterial cell counting device comprises at least one cartridge for containing reagents; an inlet for introducing a sample containing bacterial cells into the device; an optofluidic chip separately in fluid communication with the cartridge and the inlet; a filter strip passing through the optofluidic chip and in fluid communication with the cartridge and the inlet, the filter strip for trapping or retaining bacterial cells on its surface such that the bacterial cells can interact with the reagents as they flow through the filter strip; and a controller for controlling a sequential flow of reagents and sample to the filter strip via the optofluidic chip. The optofluidic chip is capable of detecting a colorimetric and/or fluorescence output emitted from the bacterial cells modified by the reagents in order for the bacterial cells to be quantified relative to a control.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• C12Q 1/06 - Quantitative determination
• G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

There is provided a method of detecting and/or determining the presence of one or more thyroid-specific nucleic acid, the method comprising annealing the one or more thyroid-specific nucleic acid in the presence of a control nucleic acid, and subjecting each of the one or more thyroid-specific nucleic acid to one or more amplification step in the presence of a mixture comprising a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the one or more thyroid-specific nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3' end. Also disclosed are methods of detecting and/or determining thyroid cancer recurrence and/or metastasis and thyroid-specific nucleic acid detection mixtures, and kits thereof.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Abstract

This disclosure relates to a method of assessing/monitoring the health of a subject, the method comprising subjecting a pancreas-associated polynucleotide to one or more amplification step in the presence of a mixture comprising a control nuclei acid, a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the target nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3' end. In one embodiment, the pancreas-associated polynucleotide is cell-free RNA and the method comprises annealing the target nucleic acid and performing a reverse transcription prior to the one or more amplification step. Also disclosed are primer and/or primer sets as disclosed herein and kits for use thereof.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6851 - Quantitative amplification
• C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

There is provided a pH-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a pH-responsive composition, the composition comprising, a copolymer comprising, a backbone moiety; and a plurality of side moieties grafted to the backbone moiety, the plurality of side moieties comprising at least one adenine-rich (A-rich) oligonucleotide and at least one cytosine-rich (C-rich) oligonucleotide; wherein the copolymer is configured to form a hydrogel when exposed to an environment with a pH falling in a first range of pH values, thereby facilitating encapsulation of the cargo within the hydrogel; and wherein the copolymer is configured to form a solution when exposed to an environment with a pH falling in a second range of pH values different from the first range of pH values, thereby facilitating release of the cargo.

IPC Classes  ?

• A61K 9/06 - Ointments; Bases therefor
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 38/28 - Insulins
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• C08F 220/56 - Acrylamide; Methacrylamide
• C08J 3/075 - Macromolecular gels

Abstract

The invention relates to a method for decellularization of tissue samples to produce decellularized extracellular matrix (dECM) by performing one or more wash cycles in a reactor using a reagent after at least partially submerging the tissue sample in the reagent, wherein the reactor comprising a tissue chamber in fluid communication with a reactor chamber. The method further comprising the steps of agitating the tissue sample and/or the reagent such that the tissue sample circulates in the reagent while retaining the tissue sample in a tissue chamber or a decellularization reactor, monitoring at least one parameter of the reagent and/or at least one parameter of the tissue sample, and adjusting one or more wash cycles based on said monitoring. The invention further relates to a decellularization reactor and a decellularization system for decel lu larizing a tissue sample.

IPC Classes  ?

• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Abstract

This disclosure relates to a method of amplification of a target nucleic acid, the method comprising subjecting the target nucleic acid to one or more amplification step in the presence of a mixture comprising a control nuclei acid, a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the target nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3' end. In one embodiment, the target nucleic acid is cell-free RNA and the method comprises annealing the target nucleic acid and performing a reverse transcription prior to the one or more amplification step. Also disclosed are nucleic acid amplification mixtures, kits for amplifications, and methods of detecting and/or determining the presence and/or the amount of a target nucleic acid.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6851 - Quantitative amplification
• C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

There is provided an anti-angiogenic agent comprising: a multi-block copolymer in the form of one or more micelles, wherein the copolymer comprises a first poly (alkylene glycol) block, a second poly (alkylene glycol) block and a polyester block. There is also provided a method of preparing said anti-angiogenic agent and medical uses of said anti-angiogenic agent.

IPC Classes  ?

• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C08G 18/48 - Polyethers
• A61P 27/02 - Ophthalmic agents

Abstract

A data collection apparatus (10) and a computer-implemented data collection method (50) using the same are provided. The data collection apparatus (10) includes a first linear stage (12) and a second linear stage (14). A sample carriage (16) is attached to the first linear stage (12), the first linear stage (12) being operable to move the sample carriage (16) along a first axis. A probe carriage (18) is attached to the second linear stage (14), the second linear stage (14) being operable to move the probe carriage (18) along a second axis. A third linear stage (20) is attached to the probe carriage (18). In use, the third linear stage (20) is operable to receive a detachable characterisation probe (22) and to move the characterisation probe (22) along a third axis. A camera (24) is attached to the probe carriage (18). In use, the camera (24) is configured to capture an image of one or more samples on the sample carriage (16).

IPC Classes  ?

• G01R 1/02 - General constructional details
• G01N 21/88 - Investigating the presence of flaws, defects or contamination
• G06T 7/00 - Image analysis
• G01R 31/00 - Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
• G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means

Abstract

The present disclosure generally relates to a flow reactor system (100) and a flow reaction method (200). The flow reactor system (100) comprises liquid pumps (110) for communicating liquid reagents based on a set of flow conditions, a fluid pump (200) for communicating a carrier fluid that is immiscible with the liquid reagents; a fluidic mixer (130) for mixing the liquid reagents into a liquid mixture, a measurement device (150) for measuring properties of liquid plugs (140) discharged from an outlet (136) of the fluidic mixer (130); and a control module configured for controlling the liquid pumps (110) and adjusting the flow conditions based on the measured properties of the liquid plugs (140), wherein the liquid plugs (140) are representative of different flow conditions.

IPC Classes  ?

• B01J 19/24 - Stationary reactors without moving elements inside
• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• B01J 14/00 - Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
• B29C 64/20 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering - Details thereof or accessories therefor
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• G01F 1/661 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters using light
• G06N 20/00 - Machine learning

Abstract

The present disclosure relates to functionalised polypeptides, nanoparticles and their 5 uses thereof. The functionalised polypeptide comprises polylysine functionalised with guanidinium moieties, wherein the polypeptide is about 50% to about 98% functionalised. The number of guanidinium functionalised lysine monomeric units is 5 to 100, and the number of lysine monomeric units is 1 to 50. The functionalised polypeptides and nanoparticles can be used for treating a microbial infection or for 10 treating cancer.

IPC Classes  ?

• C08G 69/10 - Alpha-amino-carboxylic acids
• C08G 69/48 - Polymers modified by chemical after-treatment
• A61K 31/785 - Polymers containing nitrogen
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents

Abstract

A screen-printing ink, a method (10) of manufacturing the screen-printing ink, a 5 method (50) of producing a screen-printed electrode, and a screen-printed electrode are provided. The screen-printing ink includes graphite, an electrically conductive binder to bind the graphite, a cross-linking agent to cross-link the binder, and at least one of a conductivity modifier and a hydrophobicity modifier.

IPC Classes  ?

• C09D 11/52 - Electrically conductive inks
• C09D 11/102 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions other than those only involving unsaturated carbon-to-carbon bonds
• C09D 11/106 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C09D 125/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
• C09D 201/00 - Coating compositions based on unspecified macromolecular compounds
• C08K 3/04 - Carbon
• H01M 4/04 - Processes of manufacture in general
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds

Abstract

A quantizer device and a method of quantizing a signal may be provided, the quantizer device comprising, a plurality of comparators for coupling to an integrator output of an integrator stage of a signal modulator, the plurality of comparators to perform multi-bit quantization of the integrator output; a feedback loop connection coupled to outputs of the plurality of comparators and coupled to an input of the integrator stage, the feedback loop connection for transmitting quantized outputs of the plurality of comparators as a comparator feedback signal to the input of the integrator stage; a digital-to-analog converter disposed within the feedback loop connection to perform digital-to-analog conversion of the quantized outputs of the plurality of comparators to generate the comparator feedback signal; and a gain stage disposed within the feedback loop connection to provide a gain to the comparator feedback signal.

IPC Classes  ?

• H03M 3/00 - Conversion of analogue values to or from differential modulation

Abstract

This invention relates to a method of isolating animal adipose-derived cell lines; the isolated cell lines thereof; a method of and a composition for obtaining animal adipocytes from animal adipose-derived cell lines; and a food product comprising the adipocytes and a lipid composition obtained from the adipocytes. In one embodiment, the animal is fish.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• A23L 13/00 - Meat products; Meat meal; Preparation or treatment thereof

Abstract

Various embodiments relate generally to the field of nucleic acid amplification and detection, in particular isothermal nucleic acid amplification and the detection of the amplicons using designated detection probes. Moreover, various embodiments also relate to methods for determining the presence or quantity of a target nucleic acid molecule in a sample using isothermal amplification. The detection probe is a single-stranded probe that recognises a probe binding site within target amplicons. The detection probe comprises at least one 3'end nucleotide mismatch and a quencher- fluorophore pair at the opposite ends of the probe. Following hybridization of the detection probe to the target amplicons, a DNA polymerase with 3'-5' exonuclease activity can cleave the detection probe at the 3' end nucleotide mismatch to release a 3'-terminal probe fragment comprising the quencher or fluorophore, thus generating signals.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

There is provided herein a paper-based sensor for simultaneously determining a plurality of biomarkers present in a biological sample comprising a plurality of detection zones in fluid communication with a sampling zone, wherein said plurality of detection zones comprises sensing material specific to each of said plurality of biomarkers. There is also provided herein a method of manufacturing the paper-based sensor, a use of a paper-based sensor for wound diagnosis, a kit comprising the paper-based sensor and a method of diagnosing wound health.

IPC Classes  ?

• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase

Abstract

There is provided a method of producing metal nitride particles. There are also provided core-shell particles having a sulfur-containing core and a metal nitride outer shell. There is further provided a positive electrode material comprising the core-shell particles. There are further provided a positive electrode comprising the positive electrode material and a method of preparing the same. There are further provided an electrochemical cell comprising the positive electrode as described herein and a battery comprising at least one electrochemical cell as described herein.

IPC Classes  ?

• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/1397 - Processes of manufacture of electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 10/052 - Li-accumulators
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Devices and method for synchronized light and sound emission are disclosed. The device comprises: a first electrode layer; a second electrode layer; and a composite material layer disposed between the first electrode layer and the second electrode layer, the composite material layer having an electromechanical active matrix and an electroluminescent component; and wherein the electroluminescent component comprises a plurality of particle sets dispersed in the electromechanical active matrix, each particle set being continuous and having two ends each in contact with a respective one of the first and second electrode layers.

IPC Classes  ?

• H05B 33/00 - Electroluminescent light sources
• H01L 41/083 - Piezo-electric or electrostrictive elements having a stacked or multilayer structure
• H01L 41/277 - Manufacturing multilayered piezo-electric or electrostrictive devices or parts thereof, e.g. by stacking piezo-electric bodies and electrodes by stacking bulk piezo-electric or electrostrictive bodies and electrodes
• H01L 41/193 - Macromolecular compositions
• H01L 41/45 - Organic materials

Abstract

The present invention relates, in general terms, to coronavirus 3CL protease enzyme modulators, their methods of synthesis and uses thereof. In particular, the enzyme modulators can be used for inhibiting coronavirus 3CL protease and thereby prevent replication of the virus.

IPC Classes  ?

• C07K 5/023 - Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link in which at least a beta-amino acid is involved
• C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61K 38/05 - Dipeptides
• A61K 38/06 - Tripeptides

Abstract

Discloses herein is an activated metal-organic framework of formula I as defined in the application, and the metal organic framework has a BET surface area of from 250 to 1,000 m22 333).

IPC Classes  ?

• C01F 7/00 - Compounds of aluminium
• B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C01B 32/50 - Carbon dioxide
• C01B 13/02 - Preparation of oxygen

Abstract

Herein disclosed includes a panel system operable to modulate transmission of light, which comprises, a panel comprising a cavity defined by two optically pervious conductive electrodes to house an electrolyte, a liquid reservoir, one or more pumps operable to transfer (i) the electrolyte from the cavity into the liquid reservoir so as to remove the electrolyte from the cavity and (ii) the electrolyte from the liquid reservoir back into the cavity, wherein the panel maintains a second optical state after removal of the electrolyte from the cavity and in the absence of any voltage applied to the two optically pervious conductive electrodes, and wherein the panel changes from the second optical state to a first optical state after the electrolyte is transferred from the liquid reservoir back into the cavity. Herein disclosed also includes a method of forming the panel system.

IPC Classes  ?

• G02B 5/08 - Mirrors
• G02F 1/161 - Gaskets; Spacers; Sealing of cells; Filling or closing of cells
• G02F 1/1506 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on an electrochromic effect based on electrodeposition, e.g. electrolytic deposition of an inorganic material on or close to an electrode
• E06B 5/18 - Doors, windows, or like closures for special purposes; Border constructions therefor for other protective purposes against harmful radiation

Abstract

A liquid sensor for a diaper and method of manufacturing the same are provided. The liquid sensor includes a flexible substrate, a first electrode disposed on the substrate and a plurality of second electrodes disposed on the substrate. The substrate is made of an electrically insulating material. Each of the plurality of second electrodes is electrically insulated from the first electrode and the other second electrodes. Each of the second electrodes defines a detection point for receiving a liquid. Each second electrode is configured to provide an output signal indicating a presence of the liquid at the respective detection point. The output signal comprises a potential difference between said second electrode and the first electrode. A wetness level of the diaper is determined based on the output signal of each of the second electrodes.

IPC Classes  ?

• A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
• A61F 13/49 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the shape specially adapted to be worn around the waist, e.g. diapers, nappies
• A61F 5/48 - Devices for preventing wetting or pollution of the bed