Introduced here is an approach to autofocusing in which an iterative scheme for performing pairwise comparison of digital images is performed in order to identify the optimal position for the focusing lens. This approach relies on the fact that digital images generated in rapid succession are not fully independent, but are of the same subject with different degrees of blur or defocus. In accordance with this approach, a retinal camera can proceed through a series of steps, analyzing pairs of the digital images, until the optimal position for the focusing lens is found.
2.
LOCAL NAVIGATION AIDS TO ASSIST ENDOSCOPISTS FINDING LOST POLYPS
A user-interface for visualizing a colonoscopy procedure includes a video region, a polyp annotation and identification graphic, and a lost polyp navigational aid. A live video feed received from a colonoscope is displayed in the video region. The polyp annotation depicts a location of a polyp within a colon and is presented on the live video feed. When the polyp is lost from the field of view (e.g., as a result of surgical tool insertion), the lost polyp navigation aid displays directions and/or signals to guide the endoscopist back to the lost polyp.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
3.
DETECTING AND ANALYZING SCANNING GAPS IN COLONOSCOPY VIDEOS
Methods and systems of detecting and analyzing gaps in medical videos are presented herein. Some methods may include the steps of: receiving a medical video; detecting at least one gap using a pre-trained gap detector comprising at least one neural network; and analyzing the at least one gap to determine whether one or more of the at least one gaps result in a loss of coverage using a pre-trained gap analyzer comprising at least one neural network.
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 10/96 - Management of image or video recognition tasks
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G06T 7/70 - Determining position or orientation of objects or cameras
G06V 10/98 - Detection or correction of errors, e.g. by rescanning the pattern or by human intervention; Evaluation of the quality of the acquired patterns
H04N 23/55 - Optical parts specially adapted for electronic image sensors; Mounting thereof
H04N 23/611 - Control of cameras or camera modules based on recognised objects where the recognised objects include parts of the human body
4.
ENDOSCOPIC SYSTEMS AND METHODS TO RE-IDENTIFY POLYPS USING MULTIVIEW INPUT IMAGES
An endoscopic system, methods, and a machine-learned model trained to represent an area of interest in a body, such as a polyp, are described. In an embodiment, the machine-learned model uses data comprising multiple images of the area of interest as a vector in a latent space. In an embodiment, the methods include comparing a first plurality of images of a portion of a body and a second plurality of images of a portion of the body to determine a likelihood that the first portion is the second portion.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
5.
MULTI-FRAME ANALYSIS FOR CLASSIFYING TARGET FEATURES IN MEDICAL VIDEOS
Methods, systems, and devices for classifying a target feature in a medical video are presented herein. Some methods may include the steps of: receiving a plurality of frames of the medical video, where the plurality of frames include the target feature; generating, by a first pretrained machine learning model, an embedding vector for each frame of the plurality of frames, each embedding vector having a predetermined number of values; and generating, by a second pretrained machine learning model, a classification of the target feature using the plurality of embedding vectors, where the second pretrained machine learning model analyzes the plurality of embedding vectors jointly.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
6.
ENDOSCOPIC SYSTEMS AND METHODS WITH LARGE FIELD OF VIEW AND ARTIFICIAL INTELLIGENCE SUPPORT
Methods and systems of analyzing and displaying medical videos are described herein. In some embodiments, the methods and systems may be used during an endoscopy procedure using a multi-camera endoscope having a first camera and a second camera. A method according to the present disclosure may include: receiving a first medical video from a first camera; receiving a second medical video from a second camera; detecting one or more target features of the second medical video using a pre-trained target feature detector comprising a neural network; generating an alert indicating the detection of the one or more target features in the second medical video; and displaying the first medical video and the alert on a display.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
7.
FIELD EMISSION SOURCE FOR ION MOBILITY SPECTROMETRY
In one aspect, a field emission source is disclosed herein. The field emission source may include a field emission layer having at least one structure configured to emit electrons, a spacer contacting the field emission layer, and a window layer contacting the spacer and positioned opposed the at least one structure. The window layer may be transparent to electrons. Moreover, the field emission layer, the spacer, and the window layer may form an airtight cavity. In some cases, the field emission source may be used in an ion mobility spectrometer (IMS) system.
H01J 49/06 - Electron- or ion-optical arrangements
H01J 49/08 - Electron sources, e.g. for generating photo-electrons, secondary electrons or Auger electrons
H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
8.
SYSTEMS AND METHODS FOR INGRESS SEALING OF ELECTRICAL CONTACTS FOR WEARABLE OR IMPLANTABLE DEVICES
Systems and methods for ingress sealing of electrical contacts for wearable or implantable devices are provided herein. An example device may include a housing portion defining a depression having one or more openings. The device may also include one or more electrical contacts configured to provide an electrical pathway between an external surface and an interior surface of the housing portion. The device may include an insulator disposed within the depression, the insulator including one or more apertures configured to receive the electrical contacts. The insulator may electrically isolate the electrical contacts from the housing portion and from each other. The electrical contacts may be each positioned within a respective aperture of the insulator and extend through a respective opening of the openings. The device may include an anisotropic conductive film (ACF) positioned over the electrical contacts to seal the apertures and the openings to prevent ingress of contaminants.
The present disclosure relates to systems and methods for detecting when a wearable device is being worn by a user. The systems and methods include receiving signal data from a first set of biosensors of a plurality of biosensors in a wearable device, determining an on-body or an offbody state of the wearable device based on the signal data, responsive to determining the onbody state, and enabling all of the plurality of biosensors on-body to record signal data from the plurality of biosensors. The system and methods also include, responsive to determining the offbody state, disabling a second set of the plurality of biosensors to stop recording signal data from the second of the plurality of biosensors, providing the on-body state or the off-body state to a data analysis engine, and providing the recorded signal data from the plurality of biosensors to the data analysis engine.
One example method for gene expression prediction from whole slide images includes receiving one or more images of stained tissue; generating a set of image segments from the one or more images, each image segment comprising a group of pixels from an image of the one or more images; determining, for each image segment and using a first trained machine learning ("ML") model, a vector of feature values; determining, using a second trained ML model and based on each of the vectors of feature values, a predicted gene expression; and outputting the predicted gene expression.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
11.
ESTABLISHING OPTIMAL AGGREGATION OF DATA IN SIGNALS GENERATED IN FREE-LIVING SCENARIOS
Introduced here is a computer program and associated computer-implemented techniques for establishing the optimal scope for aggregating data collected in free-living scenarios and evaluating the test-retest reliability of the data. At a high level, the computer program can serve as an end-to-end system for measuring test-retest reliability of data that is collected in free-living settings, informing the appropriate level of aggregation of the data for a given digital measurement to determine accurate reliability.
Introduced here is an ingestible device that is able to deliver medication directly into tissue along the gastrointestinal tract. Administration of a medication stored in the ingestible device can be effected by a combination of features. The ingestible device can include a plunging mechanism to which a needle is connected and a dissolvable trigger mechanism that holds the plunging mechanism in a first position. Following ingestion, the trigger mechanism may be exposed to body fluids to provoke dissolution. When the trigger mechanism dissolves, the plunging mechanism may move from the first position to a second position, thereby causing the needle to extend into tissue against which the ingestible device is lodged. Second, the needle may also be dissolved through exposure to body fluids, so as to ensure safe passage of the ingestible device through the gastrointestinal tract.
Introduced here is an ingestible device (that is able to deliver medication directly into tissue along the gastrointestinal tract. Administration of a medication stored in the ingestible device may require that the ingestible device orient itself against the tissue. To accomplish this, the ingestible device may have an asymmetrically weighted formfactor. For example, the ingestible device may be weighted along an end (also called the "weighted end") through which the needle extends in order to promote self-orientation.
Introduced here is an ingestible device that is able to deliver medication directly into tissue along the gastrointestinal tract. By designing the needle to partially or fully dissolve following exposure to body fluids, the risk of destruction and obstruction of the gastrointestinal tract can be addressed without requiring a separate retraction system. Dissolution can be achieved by constructing the needle using one or more water-soluble materials - or a combination of one or more water-soluble materials and one or more water-insoluble materials - having known dissolution properties.
A computer system may enable an end-to-end platform for evaluating digital pathology information. An example process that uses the platform may include receiving first image data corresponding to a tissue sample. The process may also include generating second image data from the first image data by applying at least one virtual stain to the first image data, where at least one virtual stain is selected based on a target clinical diagnosis. The process may also include generating, by a predictive modeling suite, third image data from the second image data by identifying a plurality of histologic features present in the second image data in accordance with the target clinical diagnosis. The process may also include generating, by the predictive modeling suite and using the third image data, a clinical prediction relating to the target clinical diagnosis. The process may also include providing information associated with the clinical prediction for presentation.
Systems and methods for determining a position of an endoscope in a portion of a body are described. In an embodiment, the system includes an endoscope comprising an endoscope body shaped to enter a portion of a body, the endoscope body defining a proximal end and a distal end opposite the proximal end; an insertion depth sensor configured to generate an insertion depth signal based on an insertion depth of the endoscope body within the portion of the body; and an inertial measurement unit disposed at the distal end of the endoscope body, the inertial measurement unit configured to generate an orientation signal based upon an orientation of the inertial measurement unit. In an embodiment, the system is configured to generate positional information of the distal end of the endoscope body within the portion of the body based upon the insertion depth signal and the orientation signal.
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A machine learning framework for breast cancer histologic grading is described herein. In an example, a method involves accessing a whole slide image of a specimen. The image is processed using a first, second, third, and fourth machine learning process. A first output of the first machine learning process indicates portions of the image predicted to depict tumor cells. A second output of the second machine learning process corresponds to a mitotic count predicted score for a mitotic count depicted in the image, a third output of the third machine learning process corresponds to a nuclear pleomorphism predicted score for nuclear pleomorphism depicted in the image, and a fourth output of the fourth machine learning process corresponds to a tubule formation predicted score for tubule formation depicted in the image. A combined score of a predicted histologic grade of a disease in the image is generated based on the outputs.
One example method for generating images of virtually stained biological samples includes receiving a first image pair comprising a first image of a biological sample and a second image of the biological sample, the first image captured using a first imaging technique and the biological sample being unstained, the second image captured using a second imaging technique different from the first imaging technique and the biological sample being stained; receiving a proposed alignment of the first image and the second image; generating alignment quality information corresponding to the first image pair, the alignment quality information indicating an alignment confidence of the first and second images; training a machine learning ("ML") model, using the first image pair and the alignment quality information, to generate an output image of the biological sample having a virtual stain according to the second imaging technique from the first image; receiving, by the ML model, a first input image of a first biological sample captured using the first imaging technique, the first biological sample being unstained; and generating, by the ML model, a first output image according to the second imaging technique, the first output image comprising a virtually stained image of the first biological sample.
A retinal imaging system and a retinal imaging adaptor and related methods of use are described. In an embodiment, the retinal imaging system comprises a monocular image sensor adapted to acquire a retinal image of an eye; and a binocular eye piece configured to slide relative to the monocular image sensor and shaped to couple to a face of a user. In an embodiment, the monocular image sensor is positioned to acquire a first retinal image of a first eye of the user in a first position of the binocular eye piece and to acquire a second retinal image of a second eye of the user in a second position of the binocular eye piece. In an embodiment, the retinal imaging system includes a sliding bracket coupled to a housing of the retinal imaging system and slidably coupled to the binocular eye piece.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
20.
PATHOLOGY AND/OR EYE-SIDED DEPENDENT ILLUMINATION FOR RETINAL IMAGING
A retinal imaging system includes an eyepiece lens assembly, an image sensor adapted to acquire a retinal image of an eye through the eyepiece lens assembly, and a controller communicatively coupled to the image sensor. The controller including logic that when executed causes the retinal imaging system to perform operations including: obtaining an indication of a pathology of interest (POI) related to the eye or an eye sidedness, selecting an eyebox location for an eyebox of the retinal imaging system based at least in part on the POI or an eye sidedness, and acquiring the retinal image of the eye when the eye is determined to be positioned within the eyebox. The eyebox corresponds to a bound region in space defined relative to the eyepiece lens assembly.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A system and method of identifying an adverse event using a video of a surgery and a two-stage surgical phase recognition module. The method includes receiving, by the module, a video of the surgery, where the video comprises a sequence of video frames. The module comprises a first stage that includes a neural network and a second stage that includes a multi-stage temporal convolution network. The method includes extracting, using the first stage, visual information content of a single frame based on the single frame; identifying, using the second stage, surgical phases captured in the frames of the video based on the visual information content from the first stage; and identifying, using the identified surgical phases, an adverse event during the surgery. An adverse event includes the omission of a surgical phase and an injury to the patient. The identification can occur in real-time or near-real-time.
An imaging system includes an endoscope tube, an illumination system, first and second image sensors, and a controller. The illumination system is coupled to the endoscope tube and configured to emit first illumination light having a first wavelength profile and excitation light having an excitation wavelength profile outside of the first wavelength profile. The first image sensor is aligned with a first filter configured to pass first image light, received in response to the first illumination light, to the first image sensor and to block the excitation light. The second image sensor is aligned with a second filter configured to pass fluorescence light, emitted in response to the excitation light, to the second image sensor. The controller includes logic to simultaneously illuminate a scene with the first illumination light and the excitation light and capture first image data and fluorescence image data with the first and second image sensors.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
23.
WORKFLOW ENHANCEMENT IN SCREENING OF OPHTHALMIC DISEASES THROUGH AUTOMATED ANALYSIS OF DIGITAL IMAGES ENABLED THROUGH MACHINE LEARNING
Introduced here are approaches to assessing digital images generated during image capture sessions using a machine learning model so as to stratify patients for examination. By applying the machine learning model to the digital images, the patients that are most in need of further examination can be identified to graders. For example, outputs produced by the diagnostic model may trigger the generation and transmission of notifications for patients that are deemed to warrant further examination.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
24.
IONIZABLE LIPIDS, LIPID NANOPARTICLES, AND USES THEREOF
Ionizable lipids and lipid nanoparticles comprising ionizable lipids are provided herein. Also provided are methods for making and using the lipid nanoparticles for delivery to a cell one or more payload agents, including polypeptides, mRNAs such as mRNA encoding Cas9 nuclease, and guide RNAs comprising backbone, sugar or base modifications.
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
25.
DRUG DELIVERY VEHICLES, METHODS OF PRODUCING DRUG DELIVERY VEHICLES, AND METHODS OF USING DRUG DELIVERY VEHICLES
The present disclosure is related to a method of producing a capsule. The method includes providing a mold, depositing parylene on the mold to form a parylene layer, scoring the parylene layer, and coating the parylene layer with a polymer to produce a capsule.
One example method includes receiving an image of a tissue sample stained with a stain; determining, by a first trained machine learning ("ML") model using the image, a first set of abnormal cells in the tissue sample; receiving an autofluorescence image of the unstained tissue sample; determining, by a second trained ML model using the autofluorescence image and the first set of cells, a second set of abnormal cells, the second set of abnormal cells being a subset of the first set of abnormal cells; and identifying the abnormal cells of the second set of abnormal cells.
A computer system may perform an image-related function using segmentation (e.g., an image mask). To begin, the system may receive image data corresponding to a surgical scene including a background that includes an anatomical feature and at least one surgical tool. The system may also generate segmentation data using a first machine learning model based on inputting the first image data to the first machine learning model. The system may also include generating a segmentation of the at least one surgical tool using the segmentation data. Once the segmentation has been generated, the system may perform an image-related function using the segmentation.
Systems and methods for de-smoking images of a surgical scene are described. Methods include receiving a video of a surgical scene including an image frame. Methods include determining that the image frame includes a smoke occlusion. Methods include determining an estimated un-occluded color of one or more pixels of the image frame using a lookup table, the lookup table mapping between a color space and a set of color bins including the estimated un-occluded color. Methods include determining a respective estimated true color for the one or more pixels of the subset using the imaged color, the estimated un-occluded color, and the smoke color. Methods also include generating a de-smoked image frame using the respective estimated true colors of the one or more pixels, the de-smoked image exhibiting a reduction of the smoke occlusion relative to the image frame.
The present disclosure is related to an apparatus and system for synthesizing and administering particle-based therapeutics at the point-of-care. The apparatus includes a first chamber for receiving a first solution including lipids in a first solvent, a second chamber for receiving a second solution including nucleic acids in a second solvent, a mixing channel in communication with the first chamber and the second chamber, and a delivery system in communication with the to the mixing channel. The first solution in the first chamber and the second solution in the second chamber can be introduced into the mixing channel. The particle-based delivery system form in the mixing channel and the nucleic acids adhere to the particles. The formulated particle-based therapeutics are passed through a delivery system to a subject for administration.
B01F 23/45 - Mixing liquids with liquids; Emulsifying using flow mixing
B01F 23/40 - Mixing liquids with liquids; Emulsifying
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
A wearable blood pressure meter includes a semi-conformable bladder, serving as a reservoir for an incompressible fluid, and a pressure sensor. The semi-conformable bladder includes a rigid housing defining a cavity within which the incompressible fluid is rigidly constrained and an elastic membrane for elastically constraining the incompressible fluid. The elastic membrane extends across an aperture into the cavity through the rigid housing. The elastic membrane conforms to a body part at the aperture when pressed against the body part. The pressure sensor mechanically couples to the incompressible fluid to measure pressure signals emanating from an artery within the body part and which propagate through the conformable membrane and the incompressible fluid to the pressure sensor.
A droplet sorting device is described. The droplet sorting device includes a primary channel, a sorting channel, a sorting electrode, a ground film, and an insulating layer. The sorting channel may intersect the primary channel to define a sorting junction. The sorting electrode may be disposed in a first plane adjacent to the sorting junction. The ground film may be disposed in a second plane that is different from the first plane. The insulating layer may be disposed in a third plane that is located between the first and second planes.
Systems and methods for specular reflection reduction in endoscope visualizations are described. A method includes receiving an image including a region of specular reflection. The method includes detecting the region of specular reflection in the image. The method includes estimating image information for a portion of the region of specular reflection. The method also includes reconstructing the image including the image information populated into the region of specular reflection.
A user-interface for aiding navigation of an endoscope through a lumen of a tubular anatomical structure during an endoscopy procedure includes a video region in which a live video feed received from the endoscope is displayed and an observation location map. The observation location map depicts a point of observation from which the live video feed is acquired within the lumen relative to a cross-sectional depiction of the lumen as the endoscope longitudinally traverses the tubular anatomical structure within the lumen during the endoscopy procedure.
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Embodiments of a system, a machine-accessible storage medium, and a computer-implemented method are described in which operations are performed. The operations comprising receiving a plurality of image frames associated with a video of an endoscopy procedure, generating a probability estimate for one or more image frames included in the plurality of image frames, and identifying a transition in the video when the endoscopy procedure transitions from a first phase to a second phase based, at least in part, on the probability estimate for the one or more image frames. The probability estimate includes a first probability that one or more image frames are associated with a first phase of the endoscopy procedure.
One example method for scene-adaptive image quality in surgical video includes receiving a first video frame from an endoscope, the first video frame generated from a first raw image captured by an image sensor of the endoscope and processed by an image signal processing ("ISP") pipeline having a plurality of ISP parameters; recognizing, using a trained machine learning ("ML") model, a first scene type or a first scene feature type based on the first video frame; determining a first set of ISP parameters based on the first scene type or the first scene feature type; applying the first set of ISP parameters to the ISP pipeline; and receiving a second video frame from the endoscope, the second video frame generated from a second raw image captured by the image sensor and processed by the ISP pipeline using the first set of ISP parameters.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
H04N 5/445 - Receiver circuitry for displaying additional information
37.
SYSTEMS AND METHODS FOR REMOTE CLINICAL EXAMS AND AUTOMATED LABELING OF SIGNAL DATA
A user device may automatically identify activities that correspond to virtual motor exam tasks and clinical tasks and auto annotate sensor data based on previous annotations and machine-learning models trained using the same. The annotations may describe context, performance, subjective, and objective information related to the performance of the activity for tracking disease or treatment progression.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
Apparatuses, machine-accessible storage media, and methods for noninvasively measuring a heart performance metric, such as left ventricular filling pressure, are described. In an embodiment, the apparatus includes a housing shaped to be grasped by a hand; a tower protruding from a surface of the housing positioned to conform to a finger of the hand when grasping the housing; a tactile sensor disposed on a curved surface of the tower and adapted to measure blood pressure pulsatility in a digital artery of the finger and output pulsatility signals indicative of the blood pressure pulsatility; a graphical user interface for orchestrating a test of the performance metric of the heart and displaying results of the test.
A user device may machine segment sensor measurements by determining a context window. The context window may include a beginning and an end. The context window may be used to define the time period in which measurements of the sensor measurements are to be segmented.
One example method for biomarker detection in digitized pathology samples includes receiving a plurality of image patches corresponding to an image of a pathology slide having a hematoxylin and eosin-stained ("H&E") stained sample of tissue, each image patch representing a different portion of the image; for each image patch, determining, using a first trained machine learning ("ML") model, a patch biomarker status; and determining, using a second trained ML model, a tissue sample biomarker status for the sample of tissue based on the patch biomarker statuses of the image patches.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
41.
PULSED LIGHT IMAGING USING ROLLING SHUTTER IMAGE SENSORS
An imaging system and method for imaging a scene using a rolling shutter are described. In an embodiment, the method includes illuminating a scene with first and second illumination light; generating frame signals with a photodetector comprising a plurality of pixels arranged in a plurality of rows, wherein the frame signals are based on light received from the scene with sequentially integrated rows of pixels of the plurality of rows, and wherein a frame signal includes signals from pixels of each of the plurality of rows; and generating images of the scene based on an intensity of the frame signals and the proportion of the first illumination light and the second illumination light emitted onto the scene during the first and second frames, wherein a proportion of the first illumination light and the second illumination light in a first frame is different than in a second frame.
An apparatus, system, and method for fluorescence imaging with stray light reduction is described. The system including a light source to provide a first illumination of a scene to induce fluorescence from the scene, an image sensor to capture a fluorescence image of the scene during the first illumination, and a controller coupled to the light source, the image sensor, and memory that includes instructions that when executed by the controller causes the system to perform operations. The operations including comparing a first color channel value to a second color channel value of a given pixel included in the fluorescence image to identify one or more pixels of the fluorescence image as being affected by stray light. The operations further including generating a stray light image mask based, at least in part, on the one or more pixels of the fluorescence image identified as being affected by the stray light.
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
43.
METHODS FOR ASSAYING TARGET PROTEINS ON EXTRACELLULAR VESICLES IN PLASMA
Provided herein are compositions and methods for assaying target proteins on extracellular vesicles in plasma. In some methods, the responsiveness of a subject to immunotherapy is determined.
One disclosed example method includes receiving sensor data from a biosensor; determining an event using a first analysis based on the sensor data, the first analysis having a first power cost; determining to perform a second analysis based on the event; in response to determining to perform the second analysis, performing the second analysis based on the sensor data, the second analysis having a second power cost greater than the first power cost; and wirelessly transmitting results of the second analysis to a remote device.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
G06F 1/3206 - Monitoring of events, devices or parameters that trigger a change in power modality
45.
ARTIFICIAL INTELLIGENCE PREDICTION OF PROSTATE CANCER OUTCOMES
One example method for AI prediction of prostate cancer outcomes involves receiving an image of prostate tissue; assigning Gleason pattern values to one or more regions within the image using an artificial intelligence Gleason grading model, the model trained to identify Gleason patterns on a patch-by-patch basis in a prostate tissue image; determining relative areal proportions of the Gleason patterns within the image; assigning at least one of a risk score or risk group value to the image based on the determined relative areal proportions; and outputting at least one of the risk score or the risk group value.
One example method for detecting events during a surgery includes receiving surgical video of a surgery comprising a plurality of video frames; identifying, by a first trained machine-learning (ML) model, an event during a surgical procedure based on the surgical video; determining, by the first trained ML model, a subset of the plurality of video frames, the subset of the plurality of video frames corresponding to the event; determining, by a second trained ML model, a characteristic of the event based on the subset of the plurality of video frames; and generating metadata corresponding to event based on the characteristic of the event.
One example method includes obtaining, from an endoscope and between first and second video frames of a real-time video having a frame rate, a preliminary image of a scene during a surgical procedure, the first image comprising a plurality of pixels, wherein the first and second video frames are consecutive video frames in the real-time video; determining, for each pixel of the plurality of pixels, a depth within the scene; determining first image capture parameters for the scene based on a scene illumination setting and a first set of pixels within a first range of depths in the scene; capturing, between the first and second consecutive output video frames, a first image using the first image capture parameters; determining an illumination correction for a second set of pixels at a second range of depths within the scene; capturing, between the first and second consecutive output video frames, a second image using the illumination correction; generating a composite image based on the first and second images; and outputting the composite image as the second output video frame.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
An insect dispensing system is described. The insect dispensing system includes a plate diverting structure supported by a frame. A first plate of the structure includes a set of channels and a second plate of the structure includes a set of apertures. The plates are aligned such that one end of each channel is aligned with one of the apertures. A population of insect pupae suspended in a liquid is dispensed into the set of channels via an inlet. As the liquid flows through the system, it is distributed among the set of channels, ultimately exiting via the apertures into a set of catch basins.
Systems and methods for transporting live insects in a secure and environmentally controlled manner. The systems include containers and packaging for transporting the live insects at a controlled temperature and pressure.
A biopotential measurement device including a plurality of sensing electrodes and a controller is described. The plurality of sensing electrodes is adapted to measure one or more biopotential signals when the plurality of sensing electrodes is worn. The controller is coupled to the plurality of sensing electrodes and memory that stores instructions that when executed by the controller cause the biopotential measurement device to perform operations. The operations include collecting electrical signals over a first time period, each of the electrical signals associated with at least one of the plurality of sensing electrodes, mixing the electrical signals to generate a biopotential dataset that includes permutations of the electrical signals, and identifying a target biopotential signal included in the one or more biopotential signals based, at least in part, on the biopotential dataset.
A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.
One example method includes obtaining one or more histopathology images of a sample from a cancer patient; selecting a plurality of tissue image patches from the one or more histopathology images; determining, by a deep learning system comprising a plurality of trained machine learning (ML) models, a plurality of image features for the plurality of tissue image patch, wherein each tissue image patch is analyzed by one of the trained ML models; determining, by the deep learning system, probabilities of patient survival based on the determined plurality of image features; and generating, by the deep learning system, a prediction of patient survival based on the determined probabilities.
The present disclosure relates to thin-film lead assemblies and neural interfaces with stent-assisted deployment, and methods of microfabricating thin-film lead assemblies and neural interfaces. Particularly, aspects of the present disclosure are directed to a medical device having a thin-film neural interface, a stent, and a cable. The thin-film neural interface includes a first supporting structure, electrodes formed on the first supporting structure, and an encapsulation material encasing a portion of the first supporting structure. The cable includes a second supporting structure, conducive traces formed on the second supporting structure and electrically connected with the electrodes, and the encapsulation material encasing at least a portion of the second supporting structure. The stent is at least partially embedded in the encapsulation material encasing the portion of the first supporting structure, and the thin-film neural interface is helically wrapped around at least a portion of the stent.
Introduced here are approaches to ensuring that digital images generated during diagnostic sessions are properly associated with the appropriate patients. By implementing these approaches, a diagnostic platform can minimize the time needed to manually input information prior to a diagnostic session and improve the accuracy of this information.
One example method includes receiving a digital image of a needle core prostate biopsy, displaying, using a display device, a magnified portion of the digital image, obtaining, from a deep learning model, Gleason scores corresponding to patches of the magnified portion of the digital image, and displaying, using the display device, a superimposed overlay on the magnified portion of the digital image based on the Gleason scores and corresponding confidence values of the Gleason scores, the superimposed overlay comprising one or more outlines corresponding one or more Gleason scores associated with the magnified portion of the digital image and comprising image patches having colors based on a Gleason score of the Gleason scores corresponding to an underlying portion of the magnified portion of the digital image and a confidence value of the corresponding Gleason score.
The present disclosure relates to a monolithic thin-film lead assembly and methods of microfabricating a monolithic thin-film lead assembly. Particularly, aspects of the present disclosure are directed to a monolithic thin-film lead assembly that includes a cable having a proximal end, a distal end, a supporting structure that extends from the proximal end to the distal end, and conductive traces formed on a portion of the supporting structure. The supporting structure includes one or more layers of dielectric material. The monolithic thin-film lead assembly further includes an interface formed on the supporting structure at the distal end of the cable. The interface includes electrodes and/or sensors in electrical connection with the conductive traces, and the supporting structure has at least one curved portion disposed between a first set of electrodes and a second set of electrodes, and/or between a first set of sensors and a second set of sensors.
A temperature measurement device for determining a body temperature of a subject includes a first temperature sensor configured to measure a plurality of skin temperatures of the subject at a plurality of time instants, a second temperature sensor spaced apart from the first temperature sensor and configured to measure a plurality of ambient temperatures at the plurality of time instants, a thermal insulation material between the first temperature sensor and the second temperature sensor, a memory device configured to store the plurality of skin temperatures and the plurality of ambient temperatures, and a controller configured to estimate, using a prediction model, the body temperature of the subject based on the plurality of skin temperatures and the plurality of ambient temperatures.
The present disclosure is directed towards systems and methods that leverage machine-learned models to decrease the rate at which abnormal sites are missed during a gastroenterological procedure. In particular, the system and methods of the present disclosure can use machine-learning techniques to determine the coverage rate achieved during a gastroenterological procedure. Measuring the coverage rate of the gastroenterological procedure can allow medical professionals to be alerted when the coverage output is deficient and thus allow an additional coverage to be achieved and as a result increase in the detection rate for abnormal sites (e.g., adenoma, polyp, lesion, tumor, etc.) during the gastroenterological procedure.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
A system includes a temperature measurement device configured to measure a plurality of body temperatures of a subject at a plurality of time instants in a time window, and a memory device configured to store the plurality of body temperatures. The system also includes a controller configured to obtain the plurality of body temperatures, determine a percentile value of the plurality of body temperatures at a first percentile, and generate an alert signal indicating that the percentile value of the plurality of body temperatures at a first percentile is greater than a threshold temperature value. The system further includes a user interface device configured to generate, based on the alert signal, a notification signal to a user of the system.
Described herein are methods and systems for containing and releasing insects in a selective manner. An example system may include a container that defines and inner volume, the container open at one end, a lid, and a roosting panel. The lid includes a port defining a load-release pathway that interfaces with an insect sorting device and enables release of insects from within the container. The roosting panel may be coupled to the lid and extend into the inner volume when the lid is secured to the container. The roosting panel includes surface for insects to grasp onto within the inner volume.
Systems and methods of improving alignment in dense prediction neural networks are disclosed. A method includes identifying, at a computing system, an input data set and a label data set with one or more first parts of the input data set corresponding to a label. The computing system processes the input data set using a neural network to generate a predicted label data set that identifies one or more second parts of the input data set predicted to correspond to the label. The computing system determines an alignment result using the predicted label data set and the label data set and a transformation of the one or more first parts, including a shift, rotation, scaling, and/or deformation, based on the alignment result. The computing system computes a loss score using the transformation, label data and the predicted label data set and updates the neural network based on the loss score.
Introduced here are containers designed to promote compliance with regimens for administering the medications stored therein. These containers can facilitate the conveyance of information related to a regimen through the use of a non-written medium. A container may include one or more display elements configured to emit/reflect light to indicate when medication stored in the container should be administered. An example of a display element is a light-emitting diode (LED). Emittance/reflectance of the light by the display element(s) may be governed by a different clock signal than the clock signal used to determine whether doses of medication are due to be administered.
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
A portable photo studio apparatus is described. The portable photo studio apparatus is configured to mount an electronic device such as a camera-enabled smartphone for capturing images of a subject in the portable photo studio without a photographer. The portable photo studio includes a bottom section on which the subject stands while being imaged. The portable photo studio also includes a background section that includes three walls. The subject stands in front of the background section while being imaged. To enable transportation and storage, the photo studio apparatus may be collapsed and assembled quickly and easily (e.g., may be assembled by a single person in a home).
E04B 1/344 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport with hinged parts
A47F 5/11 - Adjustable or foldable display stands made of cardboard, paper, or the like
B65D 5/42 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper - Details of containers or of foldable or erectable container blanks
E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport
E04H 1/12 - Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
E04H 3/22 - Theatres; Concert halls; Studios for broadcasting, cinematography, television or similar purposes
64.
EYE CUP FOR PASSIVE FEEDBACK FOR FUNDUS CAMERA ALIGNMENT
Eye cups and retinal imaging systems including an eye cup are described. In an embodiment, the eye cup is shaped to couple with an eyepiece lens assembly. In an embodiment, the eye cup includes a concave socket shaped to couple to a periorbital region of an eye, the concave socket defining a viewing aperture positioned to align with a pupil of the eye along a longitudinal axis of the viewing aperture when the concave socket is coupled to the periorbital region; and a flange extending from the concave socket away from the longitudinal axis and shaped to couple with a lateral margin of the periorbital region when the concave socket is coupled to the periorbital region. In an embodiment, an outer edge of the flange extends farther from the longitudinal axis than an outer edge of portion of the concave socket.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
Systems and methods for depth detection and virtual modeling using surgical robots during a surgical procedure are described. The robotic surgical systems include robotic arms with interchangeable surgical tools. An endoscope at the end of one of the robotic arms includes a depth sensor for detecting a distance from the camera to patient anatomy. The depth data and image data are used to generate a feature model of the patient anatomy for reference by a surgeon. The feature model is displayed to the surgeon in an augmented reality view with preoperative and intraoperative images mapped thereon for reference and guidance of a surgical procedure.
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
66.
ANATOMICALLY CONTOURED STIMULATION LEADS FOR HIGH DENSITY NEURAL INTERFACE
The present disclosure relates to implantable neuromodulation devices and methods of fabrication, and in particular to anatomically contoured spinal cord stimulation leads for high density neural interfaces and methods of microfabricating the stimulation leads. Particularly, aspects are directed to a thin film lead assembly that includes a cable having: a first supporting structure formed of dielectric material, a first set of conductive traces formed on the first supporting structure, a second supporting structure formed of dielectric material, and a second set of conductive traces formed on the second supporting structure. The thin film lead assembly also includes an electrode assembly having: a third supporting structure formed of dielectric material, a first set of electrodes in electrical connection with the first set of conductive traces, and a second set of electrodes in electrical connection with the second set of conductive traces.
A retinal camera system comprises an eyepiece lens disposed within a housing, a retinal image sensor, and a visual guidance indicator. The retinal image sensor is adapted to acquire a retinal image of an eye through the eyepiece lens. The visual guidance indicator is disposed in or on the housing peripherally about the eyepiece lens. The visual guidance indicator is positioned and oriented relative to the eyepiece lens to emit a visual cue along an optical path that does not pass through the eyepiece lens. The visual cue is adapted to facilitate alignment of the eye to the eyepiece lens.
A wearable electronic device is described. The wearable electronic device includes two communications antennae. A first antenna of the two is a current-carrying antenna electrically and physically connected to a printed circuit board of the wearable electronic device and housed in a first portion of a housing that is configured for mounting on a person's skin. A second antenna of the two is a scatterer antenna physically connected to an interior surface of a second portion of the housing and configured to overlap a portion of the current-carrying antenna. The second portion of the housing faces away from the person's skin when the wearable device is mounted on the person's skin. Current from the current- carrying antenna is induced in the scatterer antenna to enable communications between the wearable electronic device and one or more other electronic devices.
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H01Q 1/52 - Means for reducing coupling between antennas; Means for reducing coupling between an antenna and another structure
A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
Smart labels having electronic indicators are provided. According to an aspect of the invention, a label may include a first layer having a printable surface. A symbol may be printed on the printable surface. The label may also include a second layer having a flexible circuit board that includes a memory, a processor, a sensor, and an electronic indicator. The electronic indicator may be aligned with the symbol. The flexible circuit board may be configured to have a first pathway to control the electronic indicator as a function of information stored in the memory and/or a second pathway to control the electronic indicator as a function of a measurement obtained by the sensor.
G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
G09F 9/33 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements being semiconductor devices, e.g. diodes
71.
OIL-RESISTANT LENS MATERIAL AND ELECTROWETTING OPHTHALMIC DEVICES
Lens materials and ophthalmic devices including lens materials that are oxygen permeable and resistant to oil absorption are described. In an embodiment, the lens material includes a copolymer composed of repeating units including: a fluorinated acrylate repeating unit; and a silicon-containing repeating unit, wherein a mass:mass ratio of the fluorinated acrylate repeating unit to the silicon-containing repeating unit is greater than or equal to 2:1.
G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
The present disclosure relates to implantable neuromodulation devices and methods of fabrication, and in particular to a separable high density connectors for implantable neuromodulation devices. Particularly, aspects of the present disclosure are directed to a medical device comprising an electronics module and a header for connecting the electronics module to a lead assembly. The header includes: a housing that includes (i) a cavity having a central axis or plane and an internal surface, and (ii) an opening aligned with the central axis or plane of the cavity, an array of retractable contacts extending from the internal surface towards the central axis or plane of the cavity, and an array of connection terminals on the housing, where each connection terminal of the array of connection terminals is: (i) electrically connected to the electronics module, and (ii) electrically connectable to a retractable contact of the array of retractable contacts.
Systems and kits for replenishing an electrowetting ophthalmic device are described. In an embodiment, the system includes an electrowetting ophthalmic device including a lens material defining a cavity encasing an aqueous electrowetting solution; a replenishing solution having an osmolarity approximately equal to an osmolarity of the aqueous electrowetting solution; and a container shaped to carry the electrowetting ophthalmic device and the replenishing solution and to position the electrowetting ophthalmic device in contact with the replenishing solution when the electrowetting ophthalmic device and the replenishing solution are carried by the container. In an embodiment, the osmolarity of the aqueous electrowetting solution is higher than an osmolarity of a tear fluid of an eye.
G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A dynamic illuminator includes a central aperture, a ring of inner light sources, a plurality of primary illumination arrays, and a plurality of secondary illumination arrays. The ring of inner light sources is arranged around the central aperture. The plurality of primary illumination arrays extends along radial axes from the central aperture outside of the ring of inner light sources, wherein the primary illumination arrays each includes a plurality of primary light sources. The plurality of secondary illumination arrays is disposed along secondary axes extending from the central aperture outside of the ring of inner light sources. The secondary illumination arrays each includes a plurality of secondary light sources. The secondary axes of the secondary illumination arrays are disposed angularly between adjacent ones of the primary illumination arrays.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
75.
VERTICALLY POLARIZED FIELD ENHANCER FOR WEARABLE DEVICES
Disclosed herein is a wearable device having a horizontally polarized antenna and a vertically polarized antenna to gain the benefit of both types of polarization resulting in optimal signal transmission to and reception by a users smartphone or mobile device. The wearable device includes a printed circuit board on a first plane along which plane the signal from the horizontally polarized signal will propagate. The printed circuit board includes a conductive ground plane and a trace antenna conductively coupled on one end of the trace to the conductive ground plane between which the horizontally polarized field is generated when the trace antenna is excited. A vertical field enhancer, parallel to the first plane and a distance from the trace antenna, is coupled to the ground plane, such that when the trace antenna is excited, a vertically polarized field is generated between the trace antenna and the vertical field enhancer.
H01Q 1/27 - Adaptation for use in or on movable bodies
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H01Q 9/42 - Resonant antennas with feed to end of elongated active element, e.g. unipole with folded element, the folded parts being spaced apart a small fraction of the operating wavelength
H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction
H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns
H01Q 1/22 - Supports; Mounting means by structural association with other equipment or articles
76.
SYSTEMS AND METHODS FOR USING CHARACTERISTICS OF PHOTOPLETHYSMOGRAPHY (PPG) DATA TO DETECT CARDIAC CONDITIONS
In some embodiments, features are extracted from a waveform generated by a photoplethysmograph (PPG) sensor of a wearable device. These features are used to train and use classifier models to detect likely instances of cardiovascular conditions that affect blood flow during a cardiac cycle, including but not limited to atrial fibrillation. In some embodiments, the features are extracted based on the shape of the waveform, including one or more of an amplitude, an upslope rate, a downslope rate, and differentials thereof over time. In some embodiments, data from an inertial measurement unit (IMU) is used to filter and/or compensate for motion artifacts in the PPG data. The use of data generated by PPG sensors allows long-term, non-invasive monitoring for cardiovascular conditions without requiring further actions to be taken by the user to obtain data using other means.
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
77.
DETERMINING A PRESENCE OF AUTO-FLUORESCENT BIOLOGICAL SUBSTANCES THROUGH AN ARTICLE
Techniques are disclosed for detecting a presence of a biological substance through an article such as a diaper. For example, a detection system causes a light source to transmit light through the article. The light includes a peak wavelength that corresponds to an excitation wavelength of a biological substance that may be present in the article. The detection system detects a measurement of light intensity within a range of emission wavelengths of the biological substance. By comparing the measurement of light intensity to a threshold, the detection system identifies a presence of the biological substance on the article.
In some embodiments, features related to inter-beat intervals (IBI) detected by a PPG sensor of a wearable device are extracted and provided to a cardiovascular classifier in order to detect likely instances of a cardiac condition such as atrial fibrillation. Some embodiments use features related to the entropy of the IBI data to improve the predictions generated by the cardiovascular classifier. In some embodiments, co-information between the IBI data and IBI data gathered from healthy and AF populations is determined in order to derive features that represent the probability that a given sample of IBI data represents AF or a normal sinus rhythm. In response to determining likely instances of AF based on these features, the wearable device may obtain clinically acceptable data, such as an ECG, to be transmitted to a separate device for review by a clinician.
A blood extraction system can include a first lancet, a first lancet driver, a second lancet, a second lancet driver, and a blood collection vessel. A flow conduit network may extend from adjacent the first lancet and the second lancet and allow blood routing to the blood collection vessel. A sensor may be arranged to obtain information about an amount or rate of blood routed through the flow conduit network. A controller may cause the first lancet driver to drive the first lancet and receive from the sensor the information about the amount of blood routed through the flow conduit network. The controller may also cause the second lancet driver to drive the second lancet if the amount or rate of blood routed through the flow conduit network is below a threshold volume or rate after a threshold time.
A device for implanting into, or mounting onto, a body includes an enclosure, an inductive loop antenna disposed on a surface within the enclosure, and an integrated circuit (IC) disposed within the enclosure and coupled to the inductive loop antenna. The inductive loop antenna includes one or more distributed reactive loads disposed along the inductive loop antenna that adjust a reactance of the inductive loop antenna. The one or more distributed reactive loads include signal trace sections that run along, or adjacent to, the surface upon which the inductive loop antenna is disposed. The IC includes communication circuitry coupled to the inductive loop antenna to wirelessly communicate over the inductive loop antenna. The one or more distributed reactive loads adjust the reactance of the inductive loop antenna to improve conjugate reactance matching of the inductive loop antenna to the IC.
H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop
Injection device needle positioning is controlled with a needle movable in response to piston movement. A chamber with first and second ends contains the piston for travel along a travel path including first and second travel path positions. An extender proximate the first chamber end includes an extension propellant activatable to produce a first pressure at the first chamber end to move the piston from the first travel path position toward the second travel path position to cause the needle to extend. A retractor positioned proximate the second end of the chamber generates retracting movement of the piston from the second travel path position toward the first travel path position to cause the needle to retract. A vent defined through a chamber wall between the first travel position and the first chamber end dissipates at least a portion of the first pressure to facilitate the retraction.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
Devices, systems, and methods for isolating an insect pupa from an aqueous solution including a plurality of insect pupae. An isolation device may include a primary channel through which the aqueous solution and insect pupae travel, an outlet, and a secondary channel that intersects the primary channel. The secondary channel may transport a fluid to add it to the primary channel between an inlet and the outlet. When the sealable outlet is closed, an insect pupa located downstream of the intersection of the primary and secondary channels remains stationary while any insect pupae upstream of the intersection are pushed towards the inlet. The systems and methods described herein may also provide for identifying and sorting insect pupae.
An implantable medical device is described. The implantable medical device includes an enclosure for receiving and hermitically sealing active components. A header is connected to the enclosure and encloses other components of the device. A communications antenna is encapsulated in a bio-compatible material and connected to an exterior surface of the enclosure. The communications antenna is electrically connected to the active components via an access window of the header. The access window is backfilled after the connections are made.
One example device for injecting a substance into a patient includes a chamber comprising a propellant; a receiver coil arranged to activate the propellant in response to current travel through the receiver coil; a transmitter coil inductively coupled with the receiver coil; and a power source electrically coupled to the transmitter via a control circuit. In use, the control circuit applies power to the transmitter coil to induce current travel through the receiver coil for activating the propellant to trigger an action within a sequence for performing an injection.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
A61M 5/155 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons pressurised by gas
A61M 5/32 - Syringes - Details - Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
85.
ENABLING THIRD-PARTY APPLICATION EXECUTION ON ROBOTIC SURGICAL SYSTEMS
Enabling third-party application execution on robotic surgical systems are disclosed. One disclosed example computing device includes a processor; and a non-transitory computer readable medium configured to store at least executable instructions, wherein the executable instructions, when executed by the processor, cause the computing device to: receive a request to execute an application from a robotic surgical system; obtain a cryptographic signature associated with a manifest, the manifest associated with the application; in response to verification of the manifest or the application based on the cryptographic signature, determine at least one configuration setting for the application based on the manifest, the at least one configuration setting comprising a permission; configure an execution environment based on the at least one configuration setting, the at least one configuration setting enabling the application to interact with the robotic surgical system; and execute the application in the execution environment.
G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine
One example device includes a first housing portion defining a first coupling surface; a second housing portion defining a second coupling surface, the first housing portion coupled to the second housing portion to form a housing, the first housing portion and the second housing portion defining an opening, the opening intersecting the first coupling surface and the second coupling surface; a first gasket positioned between the first coupling surface and the second coupling surface, the first gasket providing a first seal between the first housing portion and the second housing portion, a printed circuit board ("PCB") disposed within the housing and coupled to at least one of the first or second housing portions; an electrical connector electrically coupled to the printed circuit board and positioned within the opening; and a second gasket positioned between the electrical connector and the housing, the second gasket providing a second seal between the electrical connector and the housing, wherein the first gasket is positioned to abut the second gasket and wherein compression of the first gasket between the first and second housing portions provides a third seal between the first gasket and the second gasket. Another example device includes a wireless field driver comprising a first antenna coil and an electrical current source electrically coupled to the first antenna coil; an electromagnetic field ("EMF") sensor comprising a second antenna coil, wherein the EMF sensor is configured to generate a sensor signal indicative of a signal strength from the first antenna coil; a non-transitory computer-readable medium; and a processor in communication with the non-transitory computer-readable medium, the processor configured to execute processor-executable instructions stored in the non-transitory computer-readable medium to: cause the electrical current source to output a current to the first antenna coil to generate a first EMF; estimate the signal strength of the first EMF based on the sensor signal; and adjust the current to the first antenna coil based on an estimated signal strength of the first EMF to maintain a power characteristic and generate a second EMF at the first antenna coil.
The present disclosure relates to mapping catheters, and in particular to mapping catheters having thin film electrodes used in sensing electrical activity within a patient. Particularly, aspects of the present disclosure are directed to a medical device having a hollow core, a balloon disposed over at least a portion of the hollow core, and a flexible framework having one or more thin film elements formed on at least a portion of the balloon. The one or more thin film elements comprise a plurality of mapping electrodes.
The present disclosure relates to connectors for high density neural interfaces and methods of microfabricating the connectors. Particularly, aspects of the present disclosure are directed to a connector having a main body, a first plug extending from the main body, a flexible bridge extending from the main body or the first plug, and a second plug extending from the flexible bridge. This structure allows for the main body, the first plug, and the second plug to be arranged in tandem on a longitudinal axis of the main body, which enables the connector to be passed through a narrow diameter cannula. This structure also allows for the first plug and the second plug to be arranged in a spread out orientation, which enables the connector to be electrically connected with a neurostimulator.
A device (100) comprising a dispenser assembly (102) comprising a frame (106) having a first surface (106a) and a second surface (106b), wherein the frame (106) defines a pathway (110) to enable movement of a movable member (108) within the frame (106), an inlet opening (112) in the first surface (106a) of the frame (106) and a drain opening (114) in the second surface (106b) of the frame (106), the inlet opening (112) and the drain opening (114) providing access to the pathway (110), wherein the frame (106) further comprises a filter (118) overlaying the drain opening (114); and a moveable member (108) translatable within the pathway (110) between a first position and a second position, the movable member (108) defining at least one bore (120), wherein at least one of the at least one bore (120) is aligned with the inlet opening (112) at the first position; and a reservoir container (104) coupled to the dispenser assembly (102), the reservoir container (104) defining a dispensing opening (122), the dispensing opening (122) aligned with the inlet opening (112) of the frame (106).
A wearable device that includes a monitoring device; and an adhesive layer stack for adhering the monitoring device to the skin of a user. The adhesive layer stack includes a first adhesive layer comprising seam(s) forming a first pattern; and a second adhesive layer comprising seam(s) forming a second pattern; wherein the second adhesive layer is configured to be stacked vertically below the monitoring device and above the first adhesive layer; wherein the first adhesive layer is configured to be stacked vertically below the second adhesive layer and the monitoring device; and wherein: the first pattern is different from the second pattern; the first pattern is offset from the second pattern; and/or the first pattern has a first size and the second pattern has a second size that is different from the first size.
An intraocular micro-display (IOMD) implant includes an enclosure shaped for implantation into an eye, a micro-display, a base lens, and an adjustable lens. The micro-display is disposed in the enclosure and oriented to emit an image towards a retina of the eye. The base lens has a fixed optical power, is attached to the enclosure, and is positioned relative to the micro-display to reside in an optical path extending between the micro-display and the retina. The base lens is configured to apply the fixed optical power to the image. The adjustable lens is disposed in the optical path between the micro-display and the retina. The adjustable lens has an adjustable optical power that is adjustable in-situ to adjust a focal distance of the image projected by the IOMD implant after the IOMD implant has been implanted into the eye.
H04N 13/344 - Displays for viewing with the aid of special glasses or head-mounted displays [HMD] with head-mounted left-right displays
H04N 13/383 - Image reproducers using viewer tracking for tracking with gaze detection, i.e. detecting the lines of sight of the viewer's eyes
G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
92.
SYSTEMS, DEVICES AND METHODS FOR OPTICAL INTERROGATION OF AN IMPLANTABLE INTRAOCULAR PRESSURE SENSOR
According to one embodiment, an intraocular pressure measurement system includes a pressure sensor implantable in an eye and comprising an optical cavity with an optical cavity depth that varies based on an intraocular pressure of the eye. The system further includes an external device for emitting light and measuring intraocular pressure based on reflected light. In an embodiment, the external device includes a light source configured to emit a plurality of beams, and a spectrometer configured to receive light reflected from at least two beams and produce an output based on the light reflected from the at least two beams. The output varies based on the depth of the optical cavity. The external device further includes a processor configured to receive the output and, based on the output, estimate the intraocular pressure of the eye.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
93.
AUTHORIZING PROGRAMMING OF AN IMPLANTED DEVICE USING SECOND FACTOR
Described herein are techniques to ensure a user using an external device is authorized to connect and connecting to a correct implantable medical device using a wireless communication protocol. A request for authorization is sent to the external device from the implantable medical device, and the authorization can be provided by an authorization pulse sent using the implantable medical device charger over the inductive link between the charging device and the implanted device. The authorization pulse can be trusted because the inductive link is short range, ensuring the patient is aware of the connection to the implanted device. Once the implanted device receives the authorization pulse, it may finalize the pairing over the first connection.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04W 12/00 - Security arrangements; Authentication; Protecting privacy or anonymity
An intraocular micro-display (IOMD) system includes an auxiliary head unit. The auxiliary head unit includes a frame for mounting to a head of a user, a scene camera module mounted in or on the frame in a forward-facing orientation, a gaze tracking module disposed in or on the frame and configured to monitor an eye of the user, and an auxiliary controller. The auxiliary controller includes for: acquiring a scene image with the scene camera module, determining a gazing direction of the eye based upon gaze direction data from the gaze tracking module, identifying a sub-portion of the scene image based upon the gazing direction, and wirelessly relaying the sub-portion of the scene image to an IOMD implant within the eye for displaying to a retina of the eye.
An intraocular micro-display system includes an intraocular micro-display (IOMD) implant and an auxiliary head unit for delivering power and image data to the IOMD implant. The IOMD implant includes an enclosure shaped for implantation into an eye, a micro-display to emit images towards a retina, an energy storage unit to power the micro-display, a charging antenna for wireless charging of the energy storage unit via a power signal incident upon the first charging antenna, and a data antenna to wirelessly receive the image data for driving the micro-display to emit the images. The charging antenna and the data antenna are implantable into the eye with the IOMD implant.
Devices, systems, and associated methods for detecting drops dispensed by a dropper are provided. For example, a drop detection device may include a light source and a light detector configured to be coupled to a drop dispenser such that the light source and light detector are disposed proximal of a distal dispensing tip of the drop dispenser. The light detector may be configured to receive a reflected portion of a beam of light from the light source, which is reflected by a drop dispensed through the dispensing tip of the drop dispenser. In some embodiments, a processing circuit is configured to analyze a signal provided by the light detector to detect the dispensed drop.
A shunt valve for removing biofluid from an eye of a user, the valve including a tubular body defining an inlet and a plurality of outlets formed through a wall of the tubular body; a plunger accommodated within the tubular body and fluidically coupled to the inlet; wherein the plunger is movable relative to the plurality of outlets; and an energized material coupled to the plunger and the tubular body; wherein the energized material is compressible to expose a portion of the plurality of outlets dependent on the pressure applied to the energized material.
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
Disclosed is a headset for monitoring periocular humidity, the headset including a housing configured to be positioned on a user's face and defining a periocular air space. The headset includes a humidity sensor configured to measure a humidity of air within the periocular air space, and an ophthalmic testing unit configured to measure a physiological parameter of an eye of the user. The headset further includes a processor coupled to the humidity sensor and the ophthalmic testing unit. The processor is configured to receive the measured humidity and the measured physiological parameter, and determine an ophthalmic condition based on the measured humidity and the measured physiological parameter.
According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.
A system for treating dry eye is presented. According to some aspects, the system includes an underlid device having an anterior surface and a posterior surface, wherein the anterior surface is configured to contact a portion of an eyelid, and wherein the posterior surface is configured to contact a portion of an eyeball. The underlid device further includes a Peltier heat pump. The Peltier heat pump includes a first surface configured to heat the eyelid when the device is positioned between the eyelid and the eyeball, and a second surface configured to cool a portion of a surface of the eyeball when the device is positioned between the eyelid and the eyeball. The underlid device further includes an energy storage element coupled to the Peltier heat pump and configured to supply power to the Peltier heat pump.
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