A method of compressing and detecting target features of a medical video is presented herein. In some embodiments, the method may include receiving an uncompressed medical video comprising at least one target feature, compressing the uncompressed medical video to generate a compressed medical video based on a predicted location of the at least one target feature using a first pretrained machine learning model, and detecting the location of the at least one target feature of the compressed medical video using a second pretrained machine learning model. In some embodiments, the first pretrained machine learning model and the second pretrained machine learning model may be trained in tandem using domain-specific medical videos.
H04N 19/50 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using predictive coding
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/40 - Scenes; Scene-specific elements in video content
H04N 19/136 - Incoming video signal characteristics or properties
H04N 19/147 - Data rate or code amount at the encoder output according to rate distortion criteria
H04N 19/184 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being bits, e.g. of the compressed video stream
H04N 19/436 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals - characterised by implementation details or hardware specially adapted for video compression or decompression, e.g. dedicated software implementation using parallelised computational arrangements
2.
SYSTEMS AND METHODS FOR BIOMARKER DETECTION IN DIGITIZED PATHOLOGY SAMPLES
One example method for biomarker detection in digitized pathology samples includes receiving a plurality of image patches corresponding to an image of a pathology slide having a hematoxylin and eosin-stained (“H&E”) stained sample of tissue, each image patch representing a different portion of the image; for each image patch, determining, using a first trained machine learning (“ML”) model, a patch biomarker status; and determining, using a second trained ML model, a tissue sample biomarker status for the sample of tissue based on the patch biomarker statuses of the image patches.
A machine learning framework for breast cancer histologic grading is described herein. In an example, a method involves accessing a whole slide image of a specimen. The image is processed using a first, second, third, and fourth machine learning process. A first output of the first machine learning process indicates portions of the image predicted to depict tumor cells. A second output of the second machine learning process corresponds to a mitotic count predicted score for a mitotic count depicted in the image, a third output of the third machine learning process corresponds to a nuclear pleomorphism predicted score for nuclear pleomorphism depicted in the image, and a fourth output of the fourth machine learning process corresponds to a tubule formation predicted score for tubule formation depicted in the image. A combined score of a predicted histologic grade of a disease in the image is generated based on the outputs.
Described herein is a front-end for a neural recording system that boosts input impedance of the front-end circuit. The front-end includes an amplifier and two choppers. A first input terminal of the first chopper may be coupled to a first output terminal from one or more signal sensors. A first input terminal of the second chopper may be coupled to a second output terminal from the signal sensors. A second input terminal of the first chopper may be coupled to a first output terminal of a feedback subsystem. A second input terminal of the second chopper may be coupled to a second output terminal of the feedback subsystem. The output terminals of each chopper may each be coupled to a different capacitor such that after switching, the voltage of each capacitor remains substantially the same, improving the input impedance of the circuit.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory services for testing wastewater for pathogens; providing information and analysis of epidemiological information and data pertaining to pathogens in wastewater
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for patient case management for use by
healthcare providers for the purpose of viewing and sharing
patient health information, performing healthcare data
analytics, generating patient insights, and managing patient
care. Providing temporary use of non-downloadable cloud-based
software for patient case management for use by healthcare
providers for the purpose of viewing and sharing patient
health information, performing healthcare data analytics,
generating patient insights, and managing patient care.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wearable devices for the detection, monitoring, and
management of health and physiological data, not for medical
use, namely, wearable activity and biometric data trackers,
and wearable computers in the nature of smartwatches not for
medical use. Wearable devices for the detection, monitoring, and
management of health and physiological data, namely,
wearable activity and biometric data trackers, wearable
computers in the nature of smartwatches, and medical
apparatus and instruments for monitoring vital signs, blood
properties and respiratory properties and events; all the
foregoing for medical use.
8.
BODY-MOUNTABLE TEMPERATURE MONITOR ACCOUNTING FOR AMBIENT CONDITIONS
A method of monitoring an internal body temperature of a patient includes detecting a skin temperature of the patient using a temperature sensor in a body-mountable temperature monitor attached to the patient; calculating, using the temperature sensor, a heat flux associated with the body-mountable temperature monitor based on selectively activating a heater in the body-mountable temperature monitor; and determining the internal body temperature of the patient using the skin temperature and the heat flux.
G01K 13/20 - Clinical contact thermometers for use with humans or animals
G01K 1/14 - Supports; Fastening devices; Arrangements for mounting thermometers in particular locations
G01K 1/143 - Supports; Fastening devices; Arrangements for mounting thermometers in particular locations for measuring surface temperatures
G01K 1/20 - Compensating for effects of temperature changes other than those to be measured, e.g. changes in ambient temperature
G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor
9.
Integrating applications in a surgeon console user interface of a robotic surgical system
One example method for improving the efficiency of robotic surgical procedures by integrating applications into the surgeon console user interface is presented. The method includes generating a surgeon console user interface for displaying at a surgeon console associated with a robotic surgical device during a robotic surgical procedure. The surgeon console user interface includes a main region configured for displaying a video signal of the robotic surgical procedure, a left side region for displaying data related to the surgical tools controlled by a left hand controller; and a right side region for displaying data related to the surgical tools controlled by a right hand controller. The method further includes displaying the graphical user interface on a display device of the surgeon console and integrating applications into the surgeon console user interface in response to determining that the surgeon console switches to an application mode.
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
10.
Health status change detection using anomaly detection in latent spaces
Individual-specific changes in health conditions are detected using a latent space mapping generated from baseline physiological data collected in a longitudinal study of the individual. Historical baseline data in an n-dimensional input space is modeled into a k-dimensional latent space, where k
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G06N 3/088 - Non-supervised learning, e.g. competitive learning
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer hardware for scientific research, namely, for
collecting, processing, and taking anatomical and tissue
images in connection with scientific and medical research;
computer hardware for capturing, transmitting and displaying
images of the eye. Retinal imaging camera for medical screening and medical
diagnostic purposes. Image-based screening services in the field of diabetic
retinopathy for medical research purposes; image-based
screening, grading and characterization services in the
field of pathology for medical research purposes; providing
diagnostic research services not for medical purposes in the
field of diabetic retinopathy research; providing
image-based diagnostic research services not for medical
purposes in the field of diabetic retinopathy research;
genetic screening for research purposes; immunophenotyping
services for research purposes; drug screening for research
services; pharmaceutical drug development services. Medical diagnostic testing, namely, image-based screening
and diagnostic services in the field of diabetic
retinopathy; medical diagnostic testing, namely, image-based
screening, diagnostic, grading and characterization services
in the field of pathology.
12.
RETINAL CAMERAS HAVING VARIABLY SIZED OPTICAL STOPS THAT ENABLE SELF-ALIGNMENT
Introduced here are retinal cameras having optical stops whose size can be adjusted to enable self-alignment by naturally guiding an eye toward a specified location. Generally, a retinal camera will constrict the bounds of an optical stop until the optical stop is aligned with the eye. In some embodiments, the optical stop is mechanically resized as a subject shifts their eye. In some embodiments, the optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack. In such embodiments, the size of the optical stop can be varied by changing which LCD layer(s) are active at a given point in time.
A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
13.
Integrating applications in a surgeon console user interface of a robotic surgical system
One example method for improving the efficiency of robotic surgical procedures by integrating applications into the surgeon console user interface is presented. The method includes generating and displaying a first graphical user interface at a surgeon console associated with a robotic surgical device during a robotic surgical procedure, and detecting a combination of user actions through control devices of the surgeon console. The method further includes responsive to detecting the combination of the user actions, causing surgical tools of the robotic surgical device to be locked and generating and displaying a second graphical user interface at the surgeon console which includes user interfaces of applications and is configured to be interactive through the control devices. The method further includes detecting a user action to exit the application mode, causing the surgical tools to be unlocked, and updating and displaying the first graphical user interface at the surgeon console.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
G05B 19/4155 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
14.
Context-aware recommendations in a health management platform user interface
A technique for generating and presenting context-aware recommendations to assist a patient in managing a chronic health condition. A health management platform provides various services that are accessible to a patient via a graphical user interface (GUI). Input data are received from various services and processed to generate contextual data associated with the patient such as a health state of the patient. Using the contextual data, a recommendation to access a particular service is generated and presented to the patient via the GUI. For example, in response to determining a health state of a patient, a recommendation to access a service to improve the health state of the patient can be automatically presented via the GUI to encourage the patient to access the service.
G06F 16/2457 - Query processing with adaptation to user needs
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
G06F 9/451 - Execution arrangements for user interfaces
G06F 16/9535 - Search customisation based on user profiles and personalisation
G06F 16/9537 - Spatial or temporal dependent retrieval, e.g. spatiotemporal queries
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
15.
SYSTEMS AND METHODS FOR DYNAMIC RELEASE PLANNING FOR INSECT RELEASE
The disclosure relates to systems and methods for dynamic release planning for insect release. One example method includes receiving information indicating a population of wild insects within a geographic region; determining a number of wild insects per unit area within the geographic region; placing, based on the number of wild insects per unit area, one or more insect release points based on the number of wild insects per unit area, each insect release point indicating a release of a predefined quantity of insects; and generating an insect release route through the geographic region, the insect release route passing through each insect release point.
A system includes an acoustic lure and a sensor package disposed within an interior volume of an insect trapping container and a computing device in communication with the acoustic lure and the sensor package configured to instruct the acoustic lure to output an acoustic tone. The computer device is further configured to receive sensor data from the sensor package, the sensor data representative of insects within the interior volume. Responsive to receiving the sensor data, the computing device is configured to instruct an imaging device to capture image data representative of the insects within the interior volume or determine insect count data based on the sensor data. The computing device is configured to then transmit output data to a remote computing system, the output data including at least one of a first portion of the image data or a second portion of the insect count data.
The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.
A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/032 - Devices for presenting test symbols or characters, e.g. test chart projectors
A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
Systems and methods for using a prediction model jointly with a normalization model to provide prediction results are provided. One example method includes receiving an input image of a tissue sample of a patient and generating a normalized image by applying a normalization model on the input image. The normalization model is configured to generate normalized data using input data for a prediction model, and the prediction model is configured to generate prediction results using normalized data generated by the normalization model. The normalization model and the prediction model are jointly trained. The method further includes generating a prediction of disease severity for the patient by applying the prediction model on the normalized image.
Provided herein are compositions and methods for assaying target proteins on extracellular vesicles in plasma. In some methods, the responsiveness of a subject to immunotherapy is determined.
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for data analytics in the fields of
drug discovery, personalized medicine and patient care
pathways. Providing data analytics and machine learning services in
the fields of drug development, personalized medicine and
patient care pathways (term considered too vague by the
International Bureau - Rule 13 (2) (b) of the Regulations);
providing non-downloadable software for data analytics in
the fields of drug discovery, personalized medicine and
patient care pathways.
21.
GENERATING IMAGES OF VIRTUALLY STAINED BIOLOGICAL SAMPLES
One example method for generating images of virtually stained biological samples includes receiving a first image pair comprising a first image of a biological sample and a second image of the biological sample, the first image captured using a first imaging technique and the biological sample being unstained, the second image captured using a second imaging technique different from the first imaging technique and the biological sample being stained; receiving a proposed alignment of the first image and the second image; generating alignment quality information corresponding to the first image pair, the alignment quality information indicating an alignment confidence of the first and second images; training a machine learning ("ML") model, using the first image pair and the alignment quality information, to generate an output image of the biological sample having a virtual stain according to the second imaging technique from the first image; receiving, by the ML model, a first input image of a first biological sample captured using the first imaging technique, the first biological sample being unstained; and generating, by the ML model, a first output image according to the second imaging technique, the first output image comprising a virtually stained image of the first biological sample.
A retinal imaging system and a retinal imaging adaptor and related methods of use are described. In an embodiment, the retinal imaging system comprises a monocular image sensor adapted to acquire a retinal image of an eye; and a binocular eye piece configured to slide relative to the monocular image sensor and shaped to couple to a face of a user. In an embodiment, the monocular image sensor is positioned to acquire a first retinal image of a first eye of the user in a first position of the binocular eye piece and to acquire a second retinal image of a second eye of the user in a second position of the binocular eye piece. In an embodiment, the retinal imaging system includes a sliding bracket coupled to a housing of the retinal imaging system and slidably coupled to the binocular eye piece.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
23.
Use of intermediate frames to capture and adjust low frame-rate, single-light source images
Systems, methods, and non-transitory, machine-readable storage media for imaging a scene are described. In an embodiment, the method includes repeatedly illuminating a scene with illumination light from a plurality of light sources; generating video feed of the scene based on the scene illuminated by the illumination light; illuminating the scene with only individual light sources of the plurality of light sources between illuminating the scene with the plurality of light sources; generating a composite image of the scene based on the scene illuminated by only the individual light sources; and adjusting the composite image based upon input received from the user interface.
Introduced here are retinal cameras having optical stops whose size and/or position can be modified to increase the size of the space in which an eye can move while being imaged. In some embodiments, an optical stop is mechanically moved to recover retinal image quality as the subject shifts their eye. In some embodiments, an optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack, and each LCD layer within the variable transmission stack may be offset from the other LCD layers. In such embodiments, the optical stop can be moved by changing which LCD layer is active at a given point in time.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
To better understand the impact of glycemic events, some entities have begun examining the relationship between the blood glucose level and another physiological parameter. However, this relationship can be difficult to understand. Introduced here are computer programs and associated computer-implemented techniques for discovering glycemic events in a series of data values representative of blood glucose measurements and then altering the measurement schedule of a sensor capable of generating measurements in a dimension other than blood glucose based on the glycemic events. By altering the measurement schedule of the sensor, a diabetes management platform can better understand how, if at all, dimensions other than blood glucose are related to the glycemic health state of a subject whose blood glucose level is being monitored.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
26.
Bi-layered neural interface with nerve-facing drug eluting structure
A implantable neural electrode assembly is described. The implantable neural electrode assembly includes a plurality of open-ended rings alternatingly connected to a spine. An inner layer of the open-ended rings is formed from a drug-loaded material (e.g., silicone that has been loaded with a steroid) and an outer layer is formed from a drug-free material. One or more electrode assemblies are connected to the inner layer and oriented towards a center of a cylinder defined by the plurality of open-ended rings.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A portable photo studio system includes a portable photo studio and an electronic device such as a camera-enabled smartphone. A computer system is provided that interacts with the electronic device. The computer system requests an image capture system. In response, the electronic device captures image data and shares it with the computer system. The computer system then analyzes the image data to identify areas of interest.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
H04N 23/54 - Mounting of pick-up tubes, electronic image sensors, deviation or focusing coils
H04N 23/56 - Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
Systems and methods for authenticating surgical tools for use in a surgical operation by a robotic surgical system are described herein. The authentication systems and methods include status lists for surgical tools associated with surgical systems. The status lists indicate an allowed or disallowed status of each surgical tool. The status list is stored on a cloud-computing system and shared with various surgical systems at different geographic locations. Prior to performing a surgical operation or at other times, the surgical systems decrypt tool data received from a surgical tool to access identifying information and access a tool status from the status list based on the tool data. The surgical systems then proceed based on the status of the surgical tool in the status list.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
The technology described herein is related to a two-phase deployment-initiated wakeup mechanism for a body-mountable electronic device. During a first phase of the two-phase wakeup mechanism, a motion sensor detects an acceleration event indicative of deployment of the device onto the body of the user. During a second phase of the two-phase mechanism, control circuitry can be adapted to be enabled by the acceleration event. Once enabled, the control circuitry can verify that the device has been launched onto the body of a user via a deployment applicator in which the device is retained until deployment. Once verified, the control circuitry can wake up the body-mountable electronic device by transitioning the device from a sleep state to a functional (or operational) state.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Wearable devices for the detection, monitoring, and management of health and physiological data, not for medical use, namely, wearable activity and biometric data trackers, and wearable computers in the nature of smartwatches not for medical use.
(2) Wearable devices for the detection, monitoring, and management of health and physiological data, namely, wearable activity and biometric data trackers, wearable computers in the nature of smartwatches, and medical apparatus and instruments for monitoring vital signs, blood properties and respiratory properties and events; all the foregoing for medical use.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer hardware for scientific research, namely, for collecting, processing, and taking anatomical and tissue images in connection with scientific and medical research; computer hardware for capturing, transmitting and displaying images of the eye.
(2) Retinal imaging camera for medical screening and medical diagnostic purposes. (1) Image-based screening services in the field of diabetic retinopathy for medical research purposes; image-based screening, grading and characterization services in the field of pathology for medical research purposes; providing diagnostic research services not for medical purposes in the field of diabetic retinopathy research; providing image-based diagnostic research services not for medical purposes in the field of diabetic retinopathy research; genetic screening for research purposes; immunophenotyping services for research purposes; drug screening for research services; pharmaceutical drug development services.
(2) Medical diagnostic testing, namely, image-based screening and diagnostic services in the field of diabetic retinopathy; medical diagnostic testing, namely, image-based screening, diagnostic, grading and characterization services in the field of pathology.
32.
Distinguishing artifacts from pathological features in digital images
Introduced here are approaches to assessing whether digital features (or simply “features”) detected in digital images by detection models are representative of artifacts that can obscure actual pathologies. A diagnostic platform may characterize each digital feature detected in a digital image based on its likelihood of being an artifact. For instance, a digital feature could be characterized as being representative of an artifact caused by improper illumination, an artifact caused by a physical element that is adhered to the lens through which light is collected by an imaging device, or a pathological feature indicative of a disease.
G06T 7/80 - Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
Systems are provided for detecting the flow of blood in vasculature by illuminating the blood with a source of coherent illumination and detecting one or more time-varying properties of a light speckle pattern that results from the scattering of the coherent illumination by tissue and blood. The movement of blood cells and other light-scattering elements in the blood causes transient, short-duration changes in the speckle pattern. High-frequency sampling or other high-bandwidth processing of a detected intensity at one or more points in the speckle pattern could be used to determine the flow of blood in the vasculature. Such flow-measuring systems are also presented as wearable devices that can be operated to detect the flow in vasculature of a wearer. Systems and methods provided herein can additionally be applied to measure flow in other scattering fluid media, for example in a scattering industrial, medical, pharmaceutical, or environmental fluid.
The present disclosure relates to activity monitoring systems and methods for gating whether or not steps should be counted in an observation window based on whether a decision tree concludes there are consecutive step activities (versus no activity or other activities) in the observation window. Particularly, certain aspects are directed to a method that includes obtaining acceleration data for an observation window of an accelerometer, inputting two or more characteristics of the acceleration data into a decision tree to determine activity occurring within the observation window, assigning a first class to the observation window when the determined activity is associated with consecutive steps, assigning a second class to the observation window when the determined activity is not associated with consecutive steps, and when the first class is assigned to the observation window, determining a step count for the observation window using frequency analysis.
The present disclosure relates to implantable neuromodulation devices, and in particular to a wireless power coil for a neuromodulation device that is to be implanted in a minimally invasive manner, for example, through a trocar or cannula. Particularly, aspects of the present disclosure are directed to a medical device that includes a lossy housing surrounding a power supply, and a receiving coil configured to exchange power wirelessly via a wireless power transfer signal and deliver the power to the power supply. The receiving coil is spaced a predetermined distance from the lossy housing. The medical device further includes a gap provided between the lossy housing and the receiving coil on a vertical plane, and a spacer that fills in at least a portion of the gap to maintain the lossy housing a predetermined distance from the receiving coil.
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
36.
Variable content customization for coaching service
A computer-implemented method of a coaching service with variable content objects. The method can include invoking a content flow including an ordered sequence of content objects. The content flow is arranged in accordance with a coaching protocol for a user of a user device. The user accesses a coaching service through the user device. The method further includes causing the user device to present a first content object. The first content object is prearranged in the ordered sequence of content objects based on information associated with the user. The method further includes dynamically selecting a second content object to replace a next content object of the ordered sequence of content objects and advancing the content flow to the second content object in lieu of the next content object and in accordance with the coaching protocol.
G09B 19/00 - Teaching not covered by other main groups of this subclass
G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
G09B 5/04 - Electrically-operated educational appliances with audible presentation of the material to be studied
G09B 5/06 - Electrically-operated educational appliances with both visual and audible presentation of the material to be studied
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
H04N 21/466 - Learning process for intelligent management, e.g. learning user preferences for recommending movies
H04N 21/482 - End-user interface for program selection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
37.
Artificial neural network model for prediction of mass spectrometry data of peptides or proteins
The present invention relates to proteomics, and techniques for predicting of mass spectrometry data of chains of amino acids, such as peptides, proteins, or combinations thereof. Particularly, aspects of the present invention are directed to a computer implemented method that includes obtaining a digital representation of a peptide sequence, the digital representation including a plurality of container elements, each container element of the plurality of container elements representing an amino acid residue; encoding, using a bidirectional recurrent neural network of long short term memory cells, each container element as an encoded vector; and decoding, using a fully-connected network, each of the encoded vectors into a theoretical output spectrum. The theoretical output spectra are represented as a one-dimensional data set or a multi-dimensional data set including intensity values for each fragment ion including one or more of the amino acid residues in the theoretical output spectra.
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.
Described herein are systems and methods of collecting, processing, and analyzing breath exhaled from a subject. Specifically, described herein are systems and methods for minimizing the amount of breath needed for analysis. Further disclosed herein are systems and methods to analyze compounds contained in a subject's breath that are indicative of certain ailments and/or present in a low concentration in the subject's breath. The systems can include a reaction chamber, a breath inlet, a reactant inlet, a fluid atomizer, and a receiving substrate for analyzing the process subject's breath. The methods can include reacting a subject's breath with a reactant to analyze the contents of the subject's breath.
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 5/08 - Measuring devices for evaluating the respiratory organs
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
40.
METHOD FOR COMPARING VIDEOS OF SURGICAL TECHNIQUES
A method for comparing videos of a surgical procedure is disclosed. The method comprising selecting a plurality of videos from a surgical video database. Each of the plurality of videos including video data of a first surgical procedure comprising a plurality of surgical steps. The method further including identifying a first surgical step included in the plurality of surgical steps within a first video segment in each of the plurality of videos. The method also including warping the first video segment to standardize a dimension of the first video segment in each of the plurality of videos.
Systems and methods for transporting live insects in a secure and environmentally controlled manner. The systems include containers and packaging for transporting the live insects at a controlled temperature and pressure.
A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
B65D 81/38 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
B65D 85/50 - Containers, packaging elements or packages, specially adapted for particular articles or materials for living organisms, articles or materials sensitive to changes of environment or atmospheric conditions, e.g. land animals, birds, fish, water plants, non-aquatic plants, flower bulbs, cut flowers or foliage
B65B 31/00 - Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
B65D 81/20 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
A system for imaging a retina of an eye includes a first lens for positioning proximate to the eye; a light source positioned to illuminate the eye when the system is aligned with the eye; an image sensor adapted to capture a retinal image of the retina through the first lens; an aperture disposed along an optical path extending from the image sensor and passing through the first lens; and a processing apparatus communicatively coupled to the image sensor and the light source, wherein the processing apparatus includes logic that when executed by the processing apparatus causes the system to perform operations including: illuminating the eye with the light source and capturing the retinal image with the image sensor.
G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
43.
COMBINED VISION AND LANGUAGE LEARNING MODELS FOR AUTOMATED MEDICAL REPORTS GENERATION
A method of generating a medical report is presented herein. In some embodiments, the method includes receiving a medical image and at least one natural language medical question, extracting at least one image feature from the image; extracting at least one text feature from the question; and fusing the at least one image feature with the at least one text feature to form a combined feature. Some embodiments further include encoding, by an encoder, the combined feature to form a transformed combined feature; computing a set of prior context features based on a similarity between the transformed combined feature and each of a set of transformed text features derived from a set of training natural language answers; and generating, by a decoder, a first natural language answer conditioned on the transformed combined feature and the set of prior context features.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G06F 40/40 - Processing or translation of natural language
G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
44.
PATHOLOGY AND/OR EYE-SIDED DEPENDENT ILLUMINATION FOR RETINAL IMAGING
A retinal imaging system includes an eyepiece lens assembly, an image sensor adapted to acquire a retinal image of an eye through the eyepiece lens assembly, and a controller communicatively coupled to the image sensor. The controller including logic that when executed causes the retinal imaging system to perform operations including: obtaining an indication of a pathology of interest (POI) related to the eye or an eye sidedness, selecting an eyebox location for an eyebox of the retinal imaging system based at least in part on the POI or an eye sidedness, and acquiring the retinal image of the eye when the eye is determined to be positioned within the eyebox. The eyebox corresponds to a bound region in space defined relative to the eyepiece lens assembly.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A system and method of identifying an adverse event using a video of a surgery and a two-stage surgical phase recognition module. The method includes receiving, by the module, a video of the surgery, where the video comprises a sequence of video frames. The module comprises a first stage that includes a neural network and a second stage that includes a multi-stage temporal convolution network. The method includes extracting, using the first stage, visual information content of a single frame based on the single frame; identifying, using the second stage, surgical phases captured in the frames of the video based on the visual information content from the first stage; and identifying, using the identified surgical phases, an adverse event during the surgery. An adverse event includes the omission of a surgical phase and an injury to the patient. The identification can occur in real-time or near-real-time.
Introduced here is a method, a system, a device, etc. for displaying health-related data (e.g., blood glucose measurements) relevant to user's selection. The method, the system, the device, etc. can be based on: receiving healthcare-related data from data streams associated with a profile of a patient; identifying, based on a least a subset of the data streams, a time window corresponding to a contextual event indicative of a patient activity that has a potential of affecting metabolism of the patient; determining a graphical representation of the contextual event; generating a graph of blood glucose level over time for display; detecting a user indication of a user interest in a time point along the graph of the blood glucose level; and highlighting the graphical representation of the contextual event in response to the time point falling within the identified time window.
G06F 3/04817 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance using icons
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G06F 9/451 - Execution arrangements for user interfaces
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
An imaging system includes an endoscope tube, an illumination system, first and second image sensors, and a controller. The illumination system is coupled to the endoscope tube and configured to emit first illumination light having a first wavelength profile and excitation light having an excitation wavelength profile outside of the first wavelength profile. The first image sensor is aligned with a first filter configured to pass first image light, received in response to the first illumination light, to the first image sensor and to block the excitation light. The second image sensor is aligned with a second filter configured to pass fluorescence light, emitted in response to the excitation light, to the second image sensor. The controller includes logic to simultaneously illuminate a scene with the first illumination light and the excitation light and capture first image data and fluorescence image data with the first and second image sensors.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
Insect storage and dispensing system are described. An example system may include a dispensing container including at least one wall defining an interior volume for retaining a plurality of adult insects. The system may also include a piston that extends through a first opening of the dispensing container so as to expose a top face of the piston to the interior volume. Longitudinal movement of the piston toward a second opening of the dispensing container may dispense a portion of the plurality of insects from the dispensing container when the plurality of insects is retained in the dispensing container.
An insect dispensing system is described. The insect dispensing system includes a plate diverting structure supported by a frame. A first plate of the structure includes a set of channels and a second plate of the structure includes a set of apertures. The plates are aligned such that one end of each channel is aligned with one of the apertures. A population of insect pupae suspended in a liquid is dispensed into the set of channels via an inlet. As the liquid flows through the system, it is distributed among the set of channels, ultimately exiting via the apertures into a set of catch basins.
An insect separating apparatus may include a sensor positioned to detect one or more insects when present within a test chamber. For example, the sensor may emit signals into the test chamber and receive reflected signals indicative of Doppler shifts caused by movement of the one or more insects. Based on information from the sensor, a computing device may determine a characteristic of the one or more insects in the chamber, such as a wing beat frequency, sex, or other characteristic. The computing device may instruct different responses based on the characteristic determined, such as activating an air mover to divert detected mosquitos out of the test chamber in response to the determined characteristics matching those of female mosquitos, or deactivating or maintaining the air mover in an inactive condition in response to the determined characteristics matching those of male mosquitos, for example, to allow passage through the chamber into a collection receptacle.
Systems and methods for continuous insects sensing are described. One example method includes receiving a flow at a singulator, the flow comprising one or more insects; singulating the insects into a single-file flow of insects; sensing, using a sensor, insects within the single-file flow of insects; and incrementing a counter based on each sensed insects in the single-file flow of insects. One example system includes a channel defining a flow path for a flow of insects; a singulator positioned within the flow path and arranged to receive the flow of insects within the channel, the singulator configured to singulate the insects into a single-file flow of insects; a sensor positioned and arranged to sense insects in the single-file flow; and a processor in communication with the sensor and a non-transitory computer-readable medium, the processor configured to execute processor-executable instructions stored in the non-transitory computer-readable medium to receive sensor signals from the sensor; and count a number of insects based on the received sensor signals.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care. (1) Providing temporary use of non-downloadable cloud-based software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care.
53.
Transforming multispectral images to enhanced resolution images enabled by machine learning
Systems and methods for predicting images with enhanced spatial resolution using a neural network are provided herein. According to an aspect of the invention, a method includes accessing an input image of a biological sample, wherein the input image includes a first spatial resolution and a plurality of spectral images, and wherein each spectral image of the plurality of spectral images includes data from a different wavelength band at a different spectral channel; applying a trained artificial neural network to the input image; generating an output image at a second spatial resolution, wherein the second spatial resolution is higher than the first spatial resolution, and wherein the output image includes a fewer number of spectral channels than the plurality of spectral images included in the input image; and outputting the output image.
In some embodiments, readily understandable information displays are provided to help an operator guide an eye of a subject into an eyebox of a retinal imaging system. In some embodiments, a three-dimensional position of the eye with respect to the retinal imaging system is determined, and an interface that includes a three-dimensional representation of the position of the eye with respect to the eyebox is generated. In some embodiments, the gaze direction may also be determined and presented in the interface, so that the operator can also prompt the subject to correct issues with incorrect gaze direction.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/02 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/08 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing binocular or stereoscopic vision, e.g. strabismus
55.
Transmitting sensitive information securely over unsecured networks without authentication
Methods and apparatus for encrypting and decrypting data for wearable devices that are not based on authentication techniques, such as login/password or handshaking, are provided. A computing device receives a message. The message includes encrypted data and a cryptographic reference. The encrypted data includes physiological data of a wearer of the wearable device. The cryptographic reference includes a reference to a first cryptographic technique. The computing device determines the first cryptographic technique based on the reference to the first cryptographic technique. The computing device determines a cryptographic key. The computing device decrypts the encrypted data using the first cryptographic technique and the cryptographic key to obtain decrypted data. The computing device stores the decrypted data.
Introduced here are approaches to assessing digital images generated during image capture sessions using a machine learning model so as to stratify patients for examination. By applying the machine learning model to the digital images, the patients that are most in need of further examination can be identified to graders. For example, outputs produced by the diagnostic model may trigger the generation and transmission of notifications for patients that are deemed to warrant further examination.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
57.
Systems for detecting carious lesions in teeth using short-wave infrared light
Systems, apparatuses, and methods for detecting carious lesions are described herein. In an example, the systems in an optical interrogator including a single-pixel photodetector responsive to short-wave infrared light and operatively coupled to a controller. In an example the optical interrogator includes a light engine for emitting light, a scanning mirror assembly and a single-pixel photodetector. In an example, the methods include causing the light engine to emit light having wavelengths in a range of about 900 nm to about 1,700 nm; selectively directing the light over different portions of a tooth with a scanning mirror assembly to provide scattered light; and correlating scattered light signals generated by the single-pixel photodetector in response to the scattered light with the portion of the tooth.
Endoscopic systems, non-transitory, machine-readable storage media, and methods for correcting brightness non-uniformity are described. In an embodiment, the endoscopic system includes a light source positioned to emit illumination light onto a scene; a photodetector positioned to receive illumination light reflected off of the scene and configured to generate a scene signal based on the received illumination light; a display; and a controller operatively coupled to the light source, the photodetector, and the display. In an embodiment, the controller including logic that, when executed by the controller, causes the endoscopic system to perform operations including: illuminating the scene with the light source; detecting a scene depth; estimating a scene-specific brightness non-uniformity correction based on the detected scene depth and an endoscopic system brightness non-uniformity profile; and displaying an image of the scene with the display based on the scene signal, the detected scene depth, and the endoscopic system brightness non-uniformity correction.
H04N 5/235 - Circuitry for compensating for variation in the brightness of the object
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
G06T 7/521 - Depth or shape recovery from the projection of structured light
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
59.
Network-connected containers having medication stored therein
Introduced here are containers designed to promote compliance with regimens for administering the medications stored therein. These containers have various features that allow them to be more easily managed by the individuals to whom the medications were prescribed. Some features improve the ease with which containers communicate with individuals. These features may enable information to be more easily input by individuals and/or output for individuals in a comprehensible manner. Other features improve the mechanical or electrical durability of containers. Such features may enable the containers to be used by individuals over the course of several days, weeks, or months without worrying about structural damage or loss of power.
G08B 5/00 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
G08B 5/36 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission using visible light sources
A61J 1/03 - Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
60.
Devices for tracking opening and closing of containers
Systems and devices for tracking the opening and closing of a container are provided. According to an aspect of the invention, a device includes a body that is configured to be inserted between a container and a cap that is configured to seal the container, a sensor that is configured to measure a state of the cap as being opened or closed, a microprocessor that is configured to receive a signal from the sensor that represents the state of the cap, and a transmitter that is configured to send a message that indicates the state of the cap.
Systems and methods are provided for continuously monitoring a user to determine when cardiovascular events are likely occurring and to responsively provide a prompt to a user to engage in additional physiological assessment of the putative cardiovascular event. Additional assessment can include the user engaging an additional sensor to provide signals that are more accurate, lower noise, or otherwise improved relative to a continuously-monitoring sensor used to initially detect the cardiovascular event. Detection of cardiovascular events includes using a cardiovascular classifier to determine, based on the output of such a continuously-monitoring sensor, whether the event is likely occurring. Such a classifier can be received from a cloud computing service or other remote system based on sensor outputs sent to such a system. Use of such a classifier can facilitate reduced false-positive detection of cardiovascular events based on the continuously-monitoring sensor, and thus reduce extraneous prompts to the user.
A system includes a display, and a database including surgical videos, images of organs in a human body obtained from a medical imaging device, and images of disease in a human body obtained from the medical imaging device. A controller including a processor is coupled to memory, the database, and the display, and the memory stores information that when executed by the processor causes the system to perform operations. For example, the processor may determine first organ information from the images of the organs, and first disease information from the images of the disease. The processor my calculate a similarity score between the first organ information and the first disease information and second disease information and second organ information indexed to the surgical videos. The processor selects one or more of the surgical videos based on the similarity score, and displays the surgical videos on the display.
G06F 16/783 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using metadata automatically derived from the content
G06F 16/71 - Indexing; Data structures therefor; Storage structures
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
Systems and methods for detecting determining a volume of urine in an absorbent article such as a diaper. A diaper loading application obtains a first measurement of ambient light received from a photodetector while a light source is off and a second measurement from the photodetector while the light source is transmitting light on an absorbent article. The application determines a normalized measurement of light reflected from an absorbent article by removing an ambient light signal from the second measurement based on the first measurement. The application determines, from the normalized measurement, a presence of urine in the absorbent article. The application further determines an estimated volume of urine in the absorbent article, wherein the determining is based on an elapsed time since the presence of urine and an activity state of an infant wearing the absorbent article.
A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
31 - Agricultural products; live animals
36 - Financial, insurance and real estate services
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software for the detection, monitoring, and management of health and physiological data; downloadable computer software for collecting, processing, analyzing, transmitting, validating and displaying health and physiological data; downloadable computer software used to manage clinical trials; computer hardware for capturing, transmitting and displaying anatomical imaging data; downloadable computer software for clinical trial data collection, storage and analysis; downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care; computer hardware for scientific research, namely, for collecting, processing, and taking anatomical and tissue images in connection with scientific and medical research; computer hardware for capturing, transmitting and displaying images of the eye; wearable devices for the detection, monitoring, and management of health and physiological data, not for medical use, namely, wearable activity and biometric data trackers, and wearable computers in the nature of smartwatches not for medical use Medical instruments and apparatus, namely, medical apparatus for detection, monitoring, and management of health and physiological data, namely, wearable activity and biometric data trackers, wearable computers in the nature of smartwatches, and medical apparatus and instruments for monitoring vital signs, blood properties and respiratory properties and events; all the foregoing for medical use Live insects and insect larvae for insect abatement scientific and medical research Providing health data analytics and care delivery data analytics and insights to insurance providers for purposes of health insurance underwriting Insect control services, namely, reducing population of disease-carrying insects through introduction of sterile males into reproducing populations, other than for agriculture, aquaculture, horticulture and forestry purposes Providing online non-downloadable software for use in collecting, analyzing and providing health data, medical data, wellness data, health risk data, and demographic data; medical research; scientific research services, namely, services for discovering, identifying, analyzing and reporting biomarkers of health and disease; drug screening and development services, namely drug screening for scientific research purposes, and pharmaceutical drug development services; medical and scientific research services in the field of screening, diagnosing, and characterizing disease based on images of anatomy; laboratory research, analysis and testing services in the fields of oncology and virology; providing temporary use of non-downloadable software for collecting, processing, analyzing, transmitting, validating and displaying data in the medical, scientific and pharmaceutical fields; providing temporary use of non-downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care; platform as a service (PAAS) featuring computer software platforms for researchers to access, share and store clinical research data and biomedical research data, and to run analytical tools; providing data analytics and machine learning services, namely analyzing and organizing clinical, laboratory and genomic data, data mining, scientific research, and machine software and artificial intelligence programing and consulting in the fields of drug development, personalized medicine and patient care pathways; providing temporary use of non-downloadable software for data analytics in the fields of drug discovery, personalized medicine and patient care pathways; providing temporary use of non-downloadable software for conducting clinical trials, including software for recruiting clinical trial participants, managing clinical trials, and collecting, storing and analyzing clinical trial data; providing temporary use of non-downloadable software for image-based medical screening, diagnostic and disease characterization purposes; laboratory services for testing wastewater for pathogens; providing information and analysis of epidemiological information and data pertaining to pathogens in wastewater for scientific research purposes and medical research purpose Medical services in the nature of providing health data analytics and care delivery data analytics and insights to patients, doctors, hospitals, and medical professionals for diagnostic and treatment purposes; laboratory testing for diagnostic and population health purposes in the fields of oncology and virology; medical services, namely, screening, diagnosing or grading the severity of a disease or health condition based on image data
65.
Virtual sidekick in a health management platform user interface
A user interface for a health management platform is described that includes a virtual sidekick configured to assist a patient in managing a chronic health condition. The virtual sidekick may represent an individual (not necessarily the patient) that is facing similar challenges as the patient such as the same chronic health condition as the patient. In some embodiments, the virtual sidekick can be presented in a virtual scene that includes one or more reverse augmented realty elements that are indicative of a physical context of the patient. For example, the virtual scene may depict visual elements indicative of the patient's physical location and/or weather conditions at the patient's physical location. Data used to personalize and dynamically animate the virtual sidekick to assist the patient in managing a chronic health condition can come from multiple different sources.
G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Methods and systems are disclosed for image process biological samples to infer biomarker values. An image of a biological sample can be accessed. The image can be segmented into a set of patches. Edge detection performed on each patch can be used to identify one or more biological features represented by the patch. An indication of the one or more features of each patch may be used to generate one or more image level metrics. A value of a biomarker may be inferred using the one or more image level metrics. The value of the biomarker can then be output.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G06V 10/56 - Extraction of image or video features relating to colour
G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
67.
IONIZABLE LIPIDS, LIPID NANOPARTICLES, AND USES THEREOF
Ionizable lipids and lipid nanoparticles comprising ionizable lipids are provided herein. Also provided are methods for making and using the lipid nanoparticles for delivery to a cell one or more payload agents, including polypeptides, mRNAs such as mRNA encoding Cas9 nuclease, and guide RNAs comprising backbone, sugar or base modifications.
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer hardware for scientific research, namely, for collecting, processing, and taking anatomical and tissue images in connection with scientific and medical research; computer hardware for capturing, transmitting and displaying images of the eye Retinal imaging camera for medical screening and medical diagnostic purposes Image-based screening services in the field of diabetic retinopathy for medical research purposes; image-based screening, grading and characterization services in the field of pathology for medical research purposes; providing diagnostic research services not for medical purposes in the field of diabetic retinopathy research; providing image-based diagnostic research services not for medical purposes in the field of diabetic retinopathy research; genetic screening for research purposes; immunophenotyping services for research purposes; drug screening for research services; pharmaceutical drug development services Medical diagnostic testing, namely, image-based screening and diagnostic services in the field of diabetic retinopathy; Medical diagnostic testing, namely, image-based screening, diagnostic, grading and characterization services in the field of pathology
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wearable devices for the detection, monitoring, and management of health and physiological data, not for medical use, namely, wearable activity and biometric data trackers, and wearable computers in the nature of smartwatches not for medical use Wearable devices for the detection, monitoring, and management of health and physiological data, namely, wearable activity and biometric data trackers, wearable computers in the nature of smartwatches, and medical apparatus and instruments for monitoring vital signs, blood properties and respiratory properties and events; all the foregoing for medical use
70.
DRUG DELIVERY VEHICLES, METHODS OF PRODUCING DRUG DELIVERY VEHICLES, AND METHODS OF USING DRUG DELIVERY VEHICLES
The present disclosure is related to a method of producing a capsule. The method includes providing a mold, depositing parylene on the mold to form a parylene layer, scoring the parylene layer, and coating the parylene layer with a polymer to produce a capsule.
A device comprises a dispenser assembly comprising a frame having a first surface and a second surface. The frame defines a pathway, an inlet opening in the first surface of the frame and a drain opening in the second surface of the frame. The inlet opening and the drain opening may provide access to the pathway. The device also includes a moveable member having at least one bore oriented perpendicular to the pathway. The moveable member may be translatable within the pathway between a first position and a second position.
A medication dispenser apparatus is described. The apparatus includes a container configured to hold medication, a display interface, and a controller configured to perform, in sequence, a learning operation in which the controller learns a medication dispensing regimen of the container, a validation operation in which the controller validates the learned medication dispensing regimen; and a notification operation in which the controller provides on the display interface a status of use of the container for medication dispensing in relation to the learned medication dispensing regimen.
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
Embodiments of the present disclosure can provide an automated mass rearing system for insect larvae. The automated mass rearing system can facilitate hatching, feeding, monitoring the growth and emergence of insect larvae and pupae. In some embodiments, the automated mass rearing system can include a production unit, a transportation unit, a storage unit, a dispensing unit, and a monitoring unit. In some embodiments, this automated mass rearing system can facilitate mass mosquito growth from egg hatching all the way through to full adults or certain stages in between such as the larvae rearing process (i.e., from larvae to pupae) with little or no human intervention. By automating the rearing and transportation of insect eggs, larvae, and pupae, deaths or developmental issues can be minimized. Various techniques and apparatuses are used in this automation that causes minimal disturbance to the insects during development, and thereby maximizing survival rate and fitness of the insects.
Various examples are described for detecting heart rate and respiratory rate by using measurements of light applied to skin through an article. For example, a sensor application obtains a set of measurements of light. The application compensates for a contribution of the article based on one or more known optical properties of the article. The sensor application further determines, from the set of measurements of light, a periodic change in amplitude. The sensor application identifies the periodic change in amplitude as a heart rate having an identical periodicity. The sensor application identifies a respiratory rate as equal to the rate of change of the heart rate.
One example method includes receiving an image of a tissue sample stained with a stain; determining, by a first trained machine learning ("ML") model using the image, a first set of abnormal cells in the tissue sample; receiving an autofluorescence image of the unstained tissue sample; determining, by a second trained ML model using the autofluorescence image and the first set of cells, a second set of abnormal cells, the second set of abnormal cells being a subset of the first set of abnormal cells; and identifying the abnormal cells of the second set of abnormal cells.
A dynamic illuminator includes a central aperture, a ring of inner light sources, a plurality of primary illumination arrays, and a plurality of secondary illumination arrays. The ring of inner light sources is arranged around the central aperture. The plurality of primary illumination arrays extends along radial axes from the central aperture outside of the ring of inner light sources, wherein the primary illumination arrays each includes a plurality of primary light sources. The plurality of secondary illumination arrays is disposed along secondary axes extending from the central aperture outside of the ring of inner light sources. The secondary illumination arrays each includes a plurality of secondary light sources. The secondary axes of the secondary illumination arrays are disposed angularly between adjacent ones of the primary illumination arrays.
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
77.
SYSTEMS AND METHODS FOR DIRECTLY PREDICTING CANCER PATIENT SURVIVAL BASED ON HISTOPATHOLOGY IMAGES
One example method includes obtaining one or more histopathology images of a sample from a cancer patient; selecting a plurality of tissue image patches from the one or more histopathology images; determining, by a deep learning system comprising a plurality of trained machine learning (ML) models, a plurality of image features for the plurality of tissue image patch, wherein each tissue image patch is analyzed by one of the trained ML models; determining, by the deep learning system, probabilities of patient survival based on the determined plurality of image features; and generating, by the deep learning system, a prediction of patient survival based on the determined probabilities.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for clinical trial data collection, storage and analysis. Providing online non-downloadable software for conducting clinical trials, including software for recruiting clinical trial participants, managing clinical trials, and collecting, storing and analyzing clinical trial data; platform as a service (PAAS) featuring computer software platforms for researchers to access, share and store clinical research data and biomedical research data, and to run analytical tools.
79.
DETECTION, IDENTIFICATION, AND VERIFICATION OF PATIENTS INVOLVED IN DIAGNOSTIC SESSIONS
Introduced here are approaches to ensuring that digital images generated during diagnostic sessions are properly associated with the appropriate patients. By implementing these approaches, a diagnostic platform can minimize the time needed to manually input information prior to a diagnostic session and improve the accuracy of this information.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
The present disclosure relates to thin-film lead assemblies and neural interfaces with stent-assisted deployment, and methods of microfabricating thin-film lead assemblies and neural interfaces. Particularly, aspects of the present disclosure are directed to a medical device having a thin-film neural interface, a stent, and a cable. The thin-film neural interface includes a first supporting structure, electrodes formed on the first supporting structure, and an encapsulation material encasing a portion of the first supporting structure. The cable includes a second supporting structure, conducive traces formed on the second supporting structure and electrically connected with the electrodes, and the encapsulation material encasing at least a portion of the second supporting structure. The stent is at least partially embedded in the encapsulation material encasing the portion of the first supporting structure, and the thin-film neural interface is helically wrapped around at least a portion of the stent.
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
Devices, systems, and methods for transporting or transferring insect pupae in an aqueous solution are described. The system includes a tank containing a solution with insect pupae, a transfer chamber having an outlet at a bottom portion of the chamber, a solution inlet, an evacuation channel, and a depth measurement system. A tube fluidly connects to tank and the transfer chamber. An evacuation device connected to the evacuation channel removes air from the transfer chamber and generates a vacuum therein to draw the solution through the tube into the transfer chamber.
One example method for detecting phases of a surgical procedure via video processing includes accessing a video of the surgical procedure and dividing the video into one or more blocks, each of the blocks containing one or more video frames. For each of the blocks, the method includes applying a prediction model on the video frames of the respective block to obtain a phase prediction for each of the video frames. The prediction model is configured to predict, for an input video frame, one of the plurality of phases of the surgical procedure. The method further includes generating an aggregated phase prediction for the respective block by aggregating the phase predictions of the video frames, and modifying the video of the surgical procedure to include an indication of a predicted phase of the respective block based on the aggregated phase prediction.
A device includes a capsule sized to pass through a lumen of a gastrointestinal tract; an enteric coating surround at least a portion of the capsule and configured to protect the capsule form stomach acid while allowing degradation of the capsule in the small intestine of the gastrointestinal tract; a plurality of functionalized particles disposed within the capsule, a plurality of tissue penetrating members configured to puncture a wall of the lumen of the intestinal tract; and an actuator having a first configuration and a second configuration. The actuator is configured to retain the plurality of functionalized particles within the capsule in the first configuration. The actuator is further configured to advance the plurality of functionalized particles from the capsule into a wall of the lumen of the gastrointestinal tract via the plurality of tissue penetrating members by the actuator transitioning from the first configuration to the second configuration.
The present disclosure relates to a monolithic thin-film lead assembly and methods of microfabricating a monolithic thin-film lead assembly. Particularly, aspects of the present disclosure are directed to a monolithic thin-film lead assembly that includes a cable having a proximal end, a distal end, a supporting structure that extends from the proximal end to the distal end, and conductive traces formed on a portion of the supporting structure. The supporting structure includes one or more layers of dielectric material. The monolithic thin-film lead assembly further includes an interface formed on the supporting structure at the distal end of the cable. The interface includes electrodes and/or sensors in electrical connection with the conductive traces, and the supporting structure has at least one curved portion disposed between a first set of electrodes and a second set of electrodes, and/or between a first set of sensors and a second set of sensors.
A computer system may perform an image-related function using segmentation (e.g., an image mask). To begin, the system may receive image data corresponding to a surgical scene including a background that includes an anatomical feature and at least one surgical tool. The system may also generate segmentation data using a first machine learning model based on inputting the first image data to the first machine learning model. The system may also include generating a segmentation of the at least one surgical tool using the segmentation data. Once the segmentation has been generated, the system may perform an image-related function using the segmentation.
A computer system may perform an image-related function using a segmentation (e.g., an image mask) that has been generated by a custom segmentation machine learning model. To begin, the system may receive image data corresponding to a surgical scene including a background that includes an anatomical feature and at least one surgical tool. The system may also generate segmentation data using the custom segmentation machine learning model based on inputting the first image data to the custom segmentation machine learning model. The system may also include generating a segmentation of the at least one surgical tool using the segmentation data. Once the segmentation has been generated, the system may perform an image-related function using the segmentation.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
87.
DYNAMIC SMOKE REDUCTION IN IMAGES FROM A SURGICAL SYSTEM
Systems and methods for de-smoking images of a surgical scene are described. Methods include receiving a video of a surgical scene including an image frame. Methods include determining that the image frame includes a smoke occlusion. Methods include determining an estimated un-occluded color of one or more pixels of the image frame using a lookup table, the lookup table mapping between a color space and a set of color bins including the estimated un-occluded color. Methods include determining a respective estimated true color for the one or more pixels of the subset using the imaged color, the estimated un-occluded color, and the smoke color. Methods also include generating a de-smoked image frame using the respective estimated true colors of the one or more pixels, the de-smoked image exhibiting a reduction of the smoke occlusion relative to the image frame.
Systems and methods for de-smoking images of a surgical scene are described. Methods include receiving a video of a surgical scene including an image frame. Methods include determining that the image frame includes a smoke occlusion. Methods include determining an estimated un-occluded color of one or more pixels of the image frame using a lookup table, the lookup table mapping between a color space and a set of color bins including the estimated un-occluded color. Methods include determining a respective estimated true color for the one or more pixels of the subset using the imaged color, the estimated un-occluded color, and the smoke color. Methods also include generating a de-smoked image frame using the respective estimated true colors of the one or more pixels, the de-smoked image exhibiting a reduction of the smoke occlusion relative to the image frame.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
H04N 23/15 - Image signal generation with circuitry for avoiding or correcting image misregistration
H04N 23/56 - Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
90.
METHODS AND SYSTEMS FOR POINT-OF-CARE SYNTHESIS AND ADMINISTRATION OF PARTICLE-BASED THERAPEUTICS
The present disclosure is related to an apparatus and system for synthesizing and administering particle-based therapeutics at the point-of-care. The apparatus includes a first chamber for receiving a first solution including lipids in a first solvent, a second chamber for receiving a second solution including nucleic acids in a second solvent, a mixing channel in communication with the first chamber and the second chamber, and a delivery system in communication with the to the mixing channel. The first solution in the first chamber and the second solution in the second chamber can be introduced into the mixing channel. The particle-based delivery system form in the mixing channel and the nucleic acids adhere to the particles. The formulated particle-based therapeutics are passed through a delivery system to a subject for administration.
B01F 23/45 - Mixing liquids with liquids; Emulsifying using flow mixing
B01F 23/40 - Mixing liquids with liquids; Emulsifying
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
Introduced here is a digital pill comprised of a capsule, an ingestible sensor, and a slot antenna. The ingestible sensor can be configured to generate a signal indicative of a characteristic of the living body in which the digital pill is located. Biometric data can be stored, at least temporarily, in a memory in the form of signal values. For example, the slot antenna may transmit biometric data to a computing device across a network on a periodic basis (e.g., every 5 minutes, 15 minutes, 60 minutes, etc.). Alternatively, the slot antenna may stream biometric data to a computing device across the network in real time.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
One example system includes a biosensor applicator having a housing defining a cavity configured to receive and physically couple to a biosensor device, and to apply the biosensor device to a wearer; an applicator coil antenna oriented around a first axis; and a biosensor device including a biosensor coil antenna; a first wireless transceiver electrically coupled to the biosensor coil antenna; a Bluetooth antenna; and a second wireless transceiver coupled to the Bluetooth antenna; wherein the biosensor device is physically coupled to the biosensor applicator and positioned at least partially within the cavity; and wherein the applicator coil antenna is configured to wirelessly receive electromagnetic (“EM”) energy from a remote coil antenna and wirelessly provide at least a first portion of the received EM energy to the biosensor coil antenna.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
H01Q 1/36 - Structural form of radiating elements, e.g. cone, spiral, umbrella
H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop
93.
Method for increasing sensor resolution by spectrally stacking responsive dyes
An analyte-sensitive substance is provided that has an optical property related to the concentration of an analyte. The analyte-sensitive substance includes an ionophore or other substance configured to provide a local pH, within the analyte-sensitive substance, that is related to the concentration of the analyte proximate the analyte-sensitive substance. The analyte-sensitive substance further includes a pH-sensitive fluorophore that increases or decreases its intrinsic fluorescence intensity with the local pH across a specified range of pH values. The analyte-sensitive substance further includes a pH-sensitive quencher configured to increase the slope of the change of fluorescence intensity of the pH-sensitive fluorophore across the specified range of pH values. The analyte-sensitive substance may further include an ionic additive configured to adjust the local pH such that the specified range of pH values corresponds to a range of analyte concentration values of interest.
The disclosed embodiments include a computer-implemented method for communications centric care. A caregiver interface serves a patient interface in accordance with a disease management program to collaboratively lead the patient to recover from a disease. The method can include obtaining content items relating to a patient and labeling each content item as either a secure content item or an unsecure content item, and then comparing the labels with identifiers of the patient, the caregiver, and/or a schedule key events of the disease management program. The content items are selectively bifurcated for the patient and/or caregiver interfaces. As such, the interfaces can manage communications in accordance with the disease management program.
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
One example method includes receiving a digital image of a needle core prostate biopsy, displaying, using a display device, a magnified portion of the digital image, obtaining, from a deep learning model, Gleason scores corresponding to patches of the magnified portion of the digital image, and displaying, using the display device, a superimposed overlay on the magnified portion of the digital image based on the Gleason scores and corresponding confidence values of the Gleason scores, the superimposed overlay comprising one or more outlines corresponding one or more Gleason scores associated with the magnified portion of the digital image and comprising image patches having colors based on a Gleason score of the Gleason scores corresponding to an underlying portion of the magnified portion of the digital image and a confidence value of the corresponding Gleason score.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care Providing temporary use of non-downloadable cloud-based software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care
97.
DIFFERENTIAL CHARGE-BALANCING DURING HIGH-FREQUENCY NEURAL STIMULATION
Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.
A male population of mosquito pupae sorted according to a sorting method is described. The sorting method may include adding a mixed population of mosquito pupae into an interior volume of a sieving container including base defining a set of openings enabling movement of mosquito pupae from the interior volume through the set of openings. The mixed population of mosquito pupae may include male mosquito pupae and female mosquito pupae. The method may also include adding a volume of aqueous solution to the interior volume. The method may also include removing a portion of the male pupae from the mixed population of mosquito pupae to by performing a sieving action that causes the portion of the male pupae and a portion of the volume of water to pass from the interior volume through the set of openings. The method may also include capturing the portion of the male pupae as the male population of mosquito pupae after the portion of the male pupae has passed through the set of openings.
A sieving device is described. The sieving device includes an adjustable sieve surface that includes a first sieve surface and a second sieve surface. Openings are formed in each of the first sieve surface and the second sieve surface so as to define a shared pathways extending through the adjustable sieve surface. The shared pathways are defined by a length dimension that is greater than a width dimension. The width dimension can correspond to a cephalothorax width of an insect.
A finger wearable device for monitoring vital signs at a finger includes a housing, a finger cuff, a plurality of vital sign sensors, and an electrocardiogram (ECG) sensor. The housing includes an interface surface for pressing against the finger. The finger cuff attaches to the housing and has a size and a shape to secure the housing to the finger and force the interface surface against the finger when the finger cuff is worn around the finger. The vital sign sensors are disposed in or on the housing and orientated to measure the vital signs from the finger of a wearer. The ECG sensor is disposed in or on the housing and coupled to first and second electrodes to measure ECG signals. The second electrode is disposed on the interface surface.
A61B 5/256 - Wearable electrodes, e.g. having straps or bands
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
