In some embodiments, readily understandable information displays are provided to help an operator guide an eye of a subject into an eyebox of a retinal imaging system. In some embodiments, a three-dimensional position of the eye with respect to the retinal imaging system is determined, and an interface that includes a three-dimensional representation of the position of the eye with respect to the eyebox is generated. In some embodiments, the gaze direction may also be determined and presented in the interface, so that the operator can also prompt the subject to correct issues with incorrect gaze direction.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/02 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/08 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing binocular or stereoscopic vision, e.g. strabismus
2.
Transmitting sensitive information securely over unsecured networks without authentication
Methods and apparatus for encrypting and decrypting data for wearable devices that are not based on authentication techniques, such as login/password or handshaking, are provided. A computing device receives a message. The message includes encrypted data and a cryptographic reference. The encrypted data includes physiological data of a wearer of the wearable device. The cryptographic reference includes a reference to a first cryptographic technique. The computing device determines the first cryptographic technique based on the reference to the first cryptographic technique. The computing device determines a cryptographic key. The computing device decrypts the encrypted data using the first cryptographic technique and the cryptographic key to obtain decrypted data. The computing device stores the decrypted data.
Introduced here are approaches to assessing digital images generated during image capture sessions using a machine learning model so as to stratify patients for examination. By applying the machine learning model to the digital images, the patients that are most in need of further examination can be identified to graders. For example, outputs produced by the diagnostic model may trigger the generation and transmission of notifications for patients that are deemed to warrant further examination.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
4.
Systems for detecting carious lesions in teeth using short-wave infrared light
Systems, apparatuses, and methods for detecting carious lesions are described herein. In an example, the systems in an optical interrogator including a single-pixel photodetector responsive to short-wave infrared light and operatively coupled to a controller. In an example the optical interrogator includes a light engine for emitting light, a scanning mirror assembly and a single-pixel photodetector. In an example, the methods include causing the light engine to emit light having wavelengths in a range of about 900 nm to about 1,700 nm; selectively directing the light over different portions of a tooth with a scanning mirror assembly to provide scattered light; and correlating scattered light signals generated by the single-pixel photodetector in response to the scattered light with the portion of the tooth.
Endoscopic systems, non-transitory, machine-readable storage media, and methods for correcting brightness non-uniformity are described. In an embodiment, the endoscopic system includes a light source positioned to emit illumination light onto a scene; a photodetector positioned to receive illumination light reflected off of the scene and configured to generate a scene signal based on the received illumination light; a display; and a controller operatively coupled to the light source, the photodetector, and the display. In an embodiment, the controller including logic that, when executed by the controller, causes the endoscopic system to perform operations including: illuminating the scene with the light source; detecting a scene depth; estimating a scene-specific brightness non-uniformity correction based on the detected scene depth and an endoscopic system brightness non-uniformity profile; and displaying an image of the scene with the display based on the scene signal, the detected scene depth, and the endoscopic system brightness non-uniformity correction.
H04N 5/235 - Circuitry for compensating for variation in the brightness of the object
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
G06T 7/521 - Depth or shape recovery from the projection of structured light
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
6.
Network-connected containers having medication stored therein
Introduced here are containers designed to promote compliance with regimens for administering the medications stored therein. These containers have various features that allow them to be more easily managed by the individuals to whom the medications were prescribed. Some features improve the ease with which containers communicate with individuals. These features may enable information to be more easily input by individuals and/or output for individuals in a comprehensible manner. Other features improve the mechanical or electrical durability of containers. Such features may enable the containers to be used by individuals over the course of several days, weeks, or months without worrying about structural damage or loss of power.
G08B 5/00 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
G08B 5/36 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission using visible light sources
A61J 1/03 - Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
7.
Devices for tracking opening and closing of containers
Systems and devices for tracking the opening and closing of a container are provided. According to an aspect of the invention, a device includes a body that is configured to be inserted between a container and a cap that is configured to seal the container, a sensor that is configured to measure a state of the cap as being opened or closed, a microprocessor that is configured to receive a signal from the sensor that represents the state of the cap, and a transmitter that is configured to send a message that indicates the state of the cap.
Systems and methods are provided for continuously monitoring a user to determine when cardiovascular events are likely occurring and to responsively provide a prompt to a user to engage in additional physiological assessment of the putative cardiovascular event. Additional assessment can include the user engaging an additional sensor to provide signals that are more accurate, lower noise, or otherwise improved relative to a continuously-monitoring sensor used to initially detect the cardiovascular event. Detection of cardiovascular events includes using a cardiovascular classifier to determine, based on the output of such a continuously-monitoring sensor, whether the event is likely occurring. Such a classifier can be received from a cloud computing service or other remote system based on sensor outputs sent to such a system. Use of such a classifier can facilitate reduced false-positive detection of cardiovascular events based on the continuously-monitoring sensor, and thus reduce extraneous prompts to the user.
A system includes a display, and a database including surgical videos, images of organs in a human body obtained from a medical imaging device, and images of disease in a human body obtained from the medical imaging device. A controller including a processor is coupled to memory, the database, and the display, and the memory stores information that when executed by the processor causes the system to perform operations. For example, the processor may determine first organ information from the images of the organs, and first disease information from the images of the disease. The processor my calculate a similarity score between the first organ information and the first disease information and second disease information and second organ information indexed to the surgical videos. The processor selects one or more of the surgical videos based on the similarity score, and displays the surgical videos on the display.
G06F 16/783 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using metadata automatically derived from the content
G06F 16/71 - Indexing; Data structures therefor; Storage structures
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
Systems and methods for detecting determining a volume of urine in an absorbent article such as a diaper. A diaper loading application obtains a first measurement of ambient light received from a photodetector while a light source is off and a second measurement from the photodetector while the light source is transmitting light on an absorbent article. The application determines a normalized measurement of light reflected from an absorbent article by removing an ambient light signal from the second measurement based on the first measurement. The application determines, from the normalized measurement, a presence of urine in the absorbent article. The application further determines an estimated volume of urine in the absorbent article, wherein the determining is based on an elapsed time since the presence of urine and an activity state of an infant wearing the absorbent article.
A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
31 - Agricultural products; live animals
36 - Financial, insurance and real estate services
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software for the detection, monitoring, and management of health and physiological data; downloadable computer software for collecting, processing, analyzing, transmitting, validating and displaying health and physiological data; downloadable computer software used to manage clinical trials; computer hardware for capturing, transmitting and displaying anatomical imaging data; downloadable computer software for clinical trial data collection, storage and analysis; downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care; computer hardware for scientific research, namely, for collecting, processing, and taking anatomical and tissue images in connection with scientific and medical research; computer hardware for capturing, transmitting and displaying images of the eye; wearable devices for the detection, monitoring, and management of health and physiological data Medical instruments and apparatus, namely, medical apparatus for detection, monitoring, and management of health and physiological data; medical apparatus for capturing, transmitting and displaying anatomical imaging data; medical apparatus for capturing, transmitting and displaying imaging data for medical screening and diagnostic purposes Live insects and insect larvae for insect abatement scientific and medical research Providing health data analytics and care delivery data analytics and insights to insurance providers for purposes of health insurance underwriting Insect control services, namely, reducing population of disease-carrying insects through introduction of sterile males into reproducing populations, other than for agriculture, aquaculture, horticulture and forestry purposes Providing online non-downloadable software for use in collecting, analyzing and providing health data, medical data, wellness data, health risk data, and demographic data; medical research; scientific research services, namely, services for discovering, identifying, analyzing and reporting biomarkers of health and disease; drug screening and development services; medical and scientific research services in the field of screening, diagnosing, and characterizing disease based on images of anatomy; laboratory research, analysis and testing services in the fields of oncology and virology; providing temporary use of non-downloadable software for collecting, processing, analyzing, transmitting, validating and displaying data in the medical, scientific and pharmaceutical fields; providing temporary use of non-downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care; platform as a service (PAAS) featuring computer software platforms for researchers to access, share and store clinical research data and biomedical research data, and to run analytical tools; providing data analytics and machine learning services in the fields of drug development, personalized medicine and patient care pathways; providing temporary use of non-downloadable software for data analytics in the fields of drug discovery, personalized medicine and patient care pathways; providing temporary use of non-downloadable software for conducting clinical trials, including software for recruiting clinical trial participants, managing clinical trials, and collecting, storing and analyzing clinical trial data; providing temporary use of non-downloadable software for image-based medical screening, diagnostic and disease characterization purposes; laboratory services for testing wastewater for pathogens; providing information and analysis of epidemiological information and data pertaining to pathogens in wastewater Medical services in the nature of providing health data analytics and care delivery data analytics and insights to patients, doctors, hospitals, and medical professionals for diagnostic and treatment purposes; laboratory testing for diagnostic and population health purposes in the fields of oncology and virology; medical services, namely, screening, diagnosing or grading the severity of a disease or health condition based on image data
12.
Virtual sidekick in a health management platform user interface
A user interface for a health management platform is described that includes a virtual sidekick configured to assist a patient in managing a chronic health condition. The virtual sidekick may represent an individual (not necessarily the patient) that is facing similar challenges as the patient such as the same chronic health condition as the patient. In some embodiments, the virtual sidekick can be presented in a virtual scene that includes one or more reverse augmented realty elements that are indicative of a physical context of the patient. For example, the virtual scene may depict visual elements indicative of the patient's physical location and/or weather conditions at the patient's physical location. Data used to personalize and dynamically animate the virtual sidekick to assist the patient in managing a chronic health condition can come from multiple different sources.
G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Methods and systems are disclosed for image process biological samples to infer biomarker values. An image of a biological sample can be accessed. The image can be segmented into a set of patches. Edge detection performed on each patch can be used to identify one or more biological features represented by the patch. An indication of the one or more features of each patch may be used to generate one or more image level metrics. A value of a biomarker may be inferred using the one or more image level metrics. The value of the biomarker can then be output.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G06V 10/56 - Extraction of image or video features relating to colour
G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
14.
IONIZABLE LIPIDS, LIPID NANOPARTICLES, AND USES THEREOF
Ionizable lipids and lipid nanoparticles comprising ionizable lipids are provided herein. Also provided are methods for making and using the lipid nanoparticles for delivery to a cell one or more payload agents, including polypeptides, mRNAs such as mRNA encoding Cas9 nuclease, and guide RNAs comprising backbone, sugar or base modifications.
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer hardware for scientific research, namely, for collecting, processing, and taking anatomical and tissue images in connection with scientific and medical research; computer hardware for capturing, transmitting and displaying images of the eye Retinal imaging camera for screening and diagnostic purposes Image-based screening and diagnostic services in the field of diabetic retinopathy; image-based screening, diagnostic, grading and characterization services in the field of pathology; genetic screening for research purposes; immunophenotyping services for research purposes; drug screening for research services; pharmaceutical drug development services
17.
DRUG DELIVERY VEHICLES, METHODS OF PRODUCING DRUG DELIVERY VEHICLES, AND METHODS OF USING DRUG DELIVERY VEHICLES
The present disclosure is related to a method of producing a capsule. The method includes providing a mold, depositing parylene on the mold to form a parylene layer, scoring the parylene layer, and coating the parylene layer with a polymer to produce a capsule.
A device comprises a dispenser assembly comprising a frame having a first surface and a second surface. The frame defines a pathway, an inlet opening in the first surface of the frame and a drain opening in the second surface of the frame. The inlet opening and the drain opening may provide access to the pathway. The device also includes a moveable member having at least one bore oriented perpendicular to the pathway. The moveable member may be translatable within the pathway between a first position and a second position.
A medication dispenser apparatus is described. The apparatus includes a container configured to hold medication, a display interface, and a controller configured to perform, in sequence, a learning operation in which the controller learns a medication dispensing regimen of the container, a validation operation in which the controller validates the learned medication dispensing regimen; and a notification operation in which the controller provides on the display interface a status of use of the container for medication dispensing in relation to the learned medication dispensing regimen.
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
Embodiments of the present disclosure can provide an automated mass rearing system for insect larvae. The automated mass rearing system can facilitate hatching, feeding, monitoring the growth and emergence of insect larvae and pupae. In some embodiments, the automated mass rearing system can include a production unit, a transportation unit, a storage unit, a dispensing unit, and a monitoring unit. In some embodiments, this automated mass rearing system can facilitate mass mosquito growth from egg hatching all the way through to full adults or certain stages in between such as the larvae rearing process (i.e., from larvae to pupae) with little or no human intervention. By automating the rearing and transportation of insect eggs, larvae, and pupae, deaths or developmental issues can be minimized. Various techniques and apparatuses are used in this automation that causes minimal disturbance to the insects during development, and thereby maximizing survival rate and fitness of the insects.
Various examples are described for detecting heart rate and respiratory rate by using measurements of light applied to skin through an article. For example, a sensor application obtains a set of measurements of light. The application compensates for a contribution of the article based on one or more known optical properties of the article. The sensor application further determines, from the set of measurements of light, a periodic change in amplitude. The sensor application identifies the periodic change in amplitude as a heart rate having an identical periodicity. The sensor application identifies a respiratory rate as equal to the rate of change of the heart rate.
One example method includes receiving an image of a tissue sample stained with a stain; determining, by a first trained machine learning ("ML") model using the image, a first set of abnormal cells in the tissue sample; receiving an autofluorescence image of the unstained tissue sample; determining, by a second trained ML model using the autofluorescence image and the first set of cells, a second set of abnormal cells, the second set of abnormal cells being a subset of the first set of abnormal cells; and identifying the abnormal cells of the second set of abnormal cells.
A dynamic illuminator includes a central aperture, a ring of inner light sources, a plurality of primary illumination arrays, and a plurality of secondary illumination arrays. The ring of inner light sources is arranged around the central aperture. The plurality of primary illumination arrays extends along radial axes from the central aperture outside of the ring of inner light sources, wherein the primary illumination arrays each includes a plurality of primary light sources. The plurality of secondary illumination arrays is disposed along secondary axes extending from the central aperture outside of the ring of inner light sources. The secondary illumination arrays each includes a plurality of secondary light sources. The secondary axes of the secondary illumination arrays are disposed angularly between adjacent ones of the primary illumination arrays.
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
24.
SYSTEMS AND METHODS FOR DIRECTLY PREDICTING CANCER PATIENT SURVIVAL BASED ON HISTOPATHOLOGY IMAGES
One example method includes obtaining one or more histopathology images of a sample from a cancer patient; selecting a plurality of tissue image patches from the one or more histopathology images; determining, by a deep learning system comprising a plurality of trained machine learning (ML) models, a plurality of image features for the plurality of tissue image patch, wherein each tissue image patch is analyzed by one of the trained ML models; determining, by the deep learning system, probabilities of patient survival based on the determined plurality of image features; and generating, by the deep learning system, a prediction of patient survival based on the determined probabilities.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for clinical trial data collection, storage and analysis. Providing online non-downloadable software for conducting clinical trials, including software for recruiting clinical trial participants, managing clinical trials, and collecting, storing and analyzing clinical trial data; platform as a service (PAAS) featuring computer software platforms for researchers to access, share and store clinical research data and biomedical research data, and to run analytical tools.
26.
DETECTION, IDENTIFICATION, AND VERIFICATION OF PATIENTS INVOLVED IN DIAGNOSTIC SESSIONS
Introduced here are approaches to ensuring that digital images generated during diagnostic sessions are properly associated with the appropriate patients. By implementing these approaches, a diagnostic platform can minimize the time needed to manually input information prior to a diagnostic session and improve the accuracy of this information.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
Devices, systems, and methods for transporting or transferring insect pupae in an aqueous solution are described. The system includes a tank containing a solution with insect pupae, a transfer chamber having an outlet at a bottom portion of the chamber, a solution inlet, an evacuation channel, and a depth measurement system. A tube fluidly connects to tank and the transfer chamber. An evacuation device connected to the evacuation channel removes air from the transfer chamber and generates a vacuum therein to draw the solution through the tube into the transfer chamber.
The present disclosure relates to thin-film lead assemblies and neural interfaces with stent-assisted deployment, and methods of microfabricating thin-film lead assemblies and neural interfaces. Particularly, aspects of the present disclosure are directed to a medical device having a thin-film neural interface, a stent, and a cable. The thin-film neural interface includes a first supporting structure, electrodes formed on the first supporting structure, and an encapsulation material encasing a portion of the first supporting structure. The cable includes a second supporting structure, conducive traces formed on the second supporting structure and electrically connected with the electrodes, and the encapsulation material encasing at least a portion of the second supporting structure. The stent is at least partially embedded in the encapsulation material encasing the portion of the first supporting structure, and the thin-film neural interface is helically wrapped around at least a portion of the stent.
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
29.
SURGICAL WORKFLOW AND ACTIVITY DETECTION BASED ON SURGICAL VIDEOS
One example method for detecting phases of a surgical procedure via video processing includes accessing a video of the surgical procedure and dividing the video into one or more blocks, each of the blocks containing one or more video frames. For each of the blocks, the method includes applying a prediction model on the video frames of the respective block to obtain a phase prediction for each of the video frames. The prediction model is configured to predict, for an input video frame, one of the plurality of phases of the surgical procedure. The method further includes generating an aggregated phase prediction for the respective block by aggregating the phase predictions of the video frames, and modifying the video of the surgical procedure to include an indication of a predicted phase of the respective block based on the aggregated phase prediction.
A device includes a capsule sized to pass through a lumen of a gastrointestinal tract; an enteric coating surround at least a portion of the capsule and configured to protect the capsule form stomach acid while allowing degradation of the capsule in the small intestine of the gastrointestinal tract; a plurality of functionalized particles disposed within the capsule, a plurality of tissue penetrating members configured to puncture a wall of the lumen of the intestinal tract; and an actuator having a first configuration and a second configuration. The actuator is configured to retain the plurality of functionalized particles within the capsule in the first configuration. The actuator is further configured to advance the plurality of functionalized particles from the capsule into a wall of the lumen of the gastrointestinal tract via the plurality of tissue penetrating members by the actuator transitioning from the first configuration to the second configuration.
The present disclosure relates to a monolithic thin-film lead assembly and methods of microfabricating a monolithic thin-film lead assembly. Particularly, aspects of the present disclosure are directed to a monolithic thin-film lead assembly that includes a cable having a proximal end, a distal end, a supporting structure that extends from the proximal end to the distal end, and conductive traces formed on a portion of the supporting structure. The supporting structure includes one or more layers of dielectric material. The monolithic thin-film lead assembly further includes an interface formed on the supporting structure at the distal end of the cable. The interface includes electrodes and/or sensors in electrical connection with the conductive traces, and the supporting structure has at least one curved portion disposed between a first set of electrodes and a second set of electrodes, and/or between a first set of sensors and a second set of sensors.
A computer system may perform an image-related function using segmentation (e.g., an image mask). To begin, the system may receive image data corresponding to a surgical scene including a background that includes an anatomical feature and at least one surgical tool. The system may also generate segmentation data using a first machine learning model based on inputting the first image data to the first machine learning model. The system may also include generating a segmentation of the at least one surgical tool using the segmentation data. Once the segmentation has been generated, the system may perform an image-related function using the segmentation.
A computer system may perform an image-related function using a segmentation (e.g., an image mask) that has been generated by a custom segmentation machine learning model. To begin, the system may receive image data corresponding to a surgical scene including a background that includes an anatomical feature and at least one surgical tool. The system may also generate segmentation data using the custom segmentation machine learning model based on inputting the first image data to the custom segmentation machine learning model. The system may also include generating a segmentation of the at least one surgical tool using the segmentation data. Once the segmentation has been generated, the system may perform an image-related function using the segmentation.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
34.
DYNAMIC SMOKE REDUCTION IN IMAGES FROM A SURGICAL SYSTEM
Systems and methods for de-smoking images of a surgical scene are described. Methods include receiving a video of a surgical scene including an image frame. Methods include determining that the image frame includes a smoke occlusion. Methods include determining an estimated un-occluded color of one or more pixels of the image frame using a lookup table, the lookup table mapping between a color space and a set of color bins including the estimated un-occluded color. Methods include determining a respective estimated true color for the one or more pixels of the subset using the imaged color, the estimated un-occluded color, and the smoke color. Methods also include generating a de-smoked image frame using the respective estimated true colors of the one or more pixels, the de-smoked image exhibiting a reduction of the smoke occlusion relative to the image frame.
Systems and methods for de-smoking images of a surgical scene are described. Methods include receiving a video of a surgical scene including an image frame. Methods include determining that the image frame includes a smoke occlusion. Methods include determining an estimated un-occluded color of one or more pixels of the image frame using a lookup table, the lookup table mapping between a color space and a set of color bins including the estimated un-occluded color. Methods include determining a respective estimated true color for the one or more pixels of the subset using the imaged color, the estimated un-occluded color, and the smoke color. Methods also include generating a de-smoked image frame using the respective estimated true colors of the one or more pixels, the de-smoked image exhibiting a reduction of the smoke occlusion relative to the image frame.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
H04N 23/15 - Image signal generation with circuitry for avoiding or correcting image misregistration
H04N 23/56 - Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
37.
METHODS AND SYSTEMS FOR POINT-OF-CARE SYNTHESIS AND ADMINISTRATION OF PARTICLE-BASED THERAPEUTICS
The present disclosure is related to an apparatus and system for synthesizing and administering particle-based therapeutics at the point-of-care. The apparatus includes a first chamber for receiving a first solution including lipids in a first solvent, a second chamber for receiving a second solution including nucleic acids in a second solvent, a mixing channel in communication with the first chamber and the second chamber, and a delivery system in communication with the to the mixing channel. The first solution in the first chamber and the second solution in the second chamber can be introduced into the mixing channel. The particle-based delivery system form in the mixing channel and the nucleic acids adhere to the particles. The formulated particle-based therapeutics are passed through a delivery system to a subject for administration.
B01F 23/45 - Mixing liquids with liquids; Emulsifying using flow mixing
B01F 23/40 - Mixing liquids with liquids; Emulsifying
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
Introduced here is a digital pill comprised of a capsule, an ingestible sensor, and a slot antenna. The ingestible sensor can be configured to generate a signal indicative of a characteristic of the living body in which the digital pill is located. Biometric data can be stored, at least temporarily, in a memory in the form of signal values. For example, the slot antenna may transmit biometric data to a computing device across a network on a periodic basis (e.g., every 5 minutes, 15 minutes, 60 minutes, etc.). Alternatively, the slot antenna may stream biometric data to a computing device across the network in real time.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
An analyte-sensitive substance is provided that has an optical property related to the concentration of an analyte. The analyte-sensitive substance includes an ionophore or other substance configured to provide a local pH, within the analyte-sensitive substance, that is related to the concentration of the analyte proximate the analyte-sensitive substance. The analyte-sensitive substance further includes a pH-sensitive fluorophore that increases or decreases its intrinsic fluorescence intensity with the local pH across a specified range of pH values. The analyte-sensitive substance further includes a pH-sensitive quencher configured to increase the slope of the change of fluorescence intensity of the pH-sensitive fluorophore across the specified range of pH values. The analyte-sensitive substance may further include an ionic additive configured to adjust the local pH such that the specified range of pH values corresponds to a range of analyte concentration values of interest.
The disclosed embodiments include a computer-implemented method for communications centric care. A caregiver interface serves a patient interface in accordance with a disease management program to collaboratively lead the patient to recover from a disease. The method can include obtaining content items relating to a patient and labeling each content item as either a secure content item or an unsecure content item, and then comparing the labels with identifiers of the patient, the caregiver, and/or a schedule key events of the disease management program. The content items are selectively bifurcated for the patient and/or caregiver interfaces. As such, the interfaces can manage communications in accordance with the disease management program.
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
One example method includes receiving a digital image of a needle core prostate biopsy, displaying, using a display device, a magnified portion of the digital image, obtaining, from a deep learning model, Gleason scores corresponding to patches of the magnified portion of the digital image, and displaying, using the display device, a superimposed overlay on the magnified portion of the digital image based on the Gleason scores and corresponding confidence values of the Gleason scores, the superimposed overlay comprising one or more outlines corresponding one or more Gleason scores associated with the magnified portion of the digital image and comprising image patches having colors based on a Gleason score of the Gleason scores corresponding to an underlying portion of the magnified portion of the digital image and a confidence value of the corresponding Gleason score.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care Providing temporary access to non-downloadable cloud-based software for patient case management for use by healthcare providers for the purpose of viewing and sharing patient health information, performing healthcare data analytics, generating patient insights, and managing patient care
43.
DIFFERENTIAL CHARGE-BALANCING DURING HIGH-FREQUENCY NEURAL STIMULATION
Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.
A male population of mosquito pupae sorted according to a sorting method is described. The sorting method may include adding a mixed population of mosquito pupae into an interior volume of a sieving container including base defining a set of openings enabling movement of mosquito pupae from the interior volume through the set of openings. The mixed population of mosquito pupae may include male mosquito pupae and female mosquito pupae. The method may also include adding a volume of aqueous solution to the interior volume. The method may also include removing a portion of the male pupae from the mixed population of mosquito pupae to by performing a sieving action that causes the portion of the male pupae and a portion of the volume of water to pass from the interior volume through the set of openings. The method may also include capturing the portion of the male pupae as the male population of mosquito pupae after the portion of the male pupae has passed through the set of openings.
A sieving device is described. The sieving device includes an adjustable sieve surface that includes a first sieve surface and a second sieve surface. Openings are formed in each of the first sieve surface and the second sieve surface so as to define a shared pathways extending through the adjustable sieve surface. The shared pathways are defined by a length dimension that is greater than a width dimension. The width dimension can correspond to a cephalothorax width of an insect.
A finger wearable device for monitoring vital signs at a finger includes a housing, a finger cuff, a plurality of vital sign sensors, and an electrocardiogram (ECG) sensor. The housing includes an interface surface for pressing against the finger. The finger cuff attaches to the housing and has a size and a shape to secure the housing to the finger and force the interface surface against the finger when the finger cuff is worn around the finger. The vital sign sensors are disposed in or on the housing and orientated to measure the vital signs from the finger of a wearer. The ECG sensor is disposed in or on the housing and coupled to first and second electrodes to measure ECG signals. The second electrode is disposed on the interface surface.
A61B 5/256 - Wearable electrodes, e.g. having straps or bands
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
Methods, endoscopic systems, and non-transitory, machine-readable storage media for adjusting an exposure of an endoscopic system are described. In an embodiment, the methods include emitting light with a light source into a proximal end of an endoscope light pipe; generating received light signals with a photodetector based on light received through the endoscope light pipe by the photodetector; displaying, with a display module, images based on the received light signals having a current image brightness; monitoring the received light signals for changes to the current image brightness; and adjusting a light source illuminance level, and in some embodiments a photodetector gain and exposure time, based on the current image brightness to maintain a target image brightness of the display module. In an embodiment, a brightness adjustment step size is less than a just-noticeable difference in brightness of an eye and is directly proportional to the current image brightness.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
H04N 5/235 - Circuitry for compensating for variation in the brightness of the object
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
Microfluidic pumps are provided that use electrowetting to manipulate the location of one or more droplets of a working fluid (e.g., water) in order to pump tears, blood, laboratory samples, carrier fluid, or some other payload fluid. The working fluid is separated from the payload fluid by one or more droplets of an isolating fluid that is immiscible with the working fluid. The working fluid is manipulated via electrowetting, by applying voltages to two or more electrodes, to repeatedly move back and forth. Forces, pressures, and/or fluid flows exerted by the working fluid are coupled to the payload fluid via the droplet(s) of isolation fluid and reed valves, diffuser nozzles, or other varieties of valve can act as flow-rectifying elements to convert the coupled forces into a net flow of the payload fluid through the pump.
F04B 39/00 - Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups
F04B 9/10 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid
A computer-implemented method for dynamically reallocating resources to users of a coaching service. The method can include initially allocating resources to users of the coaching service, receiving indications of activities of the users relative to their allocated resources, and comparing the activities relative to a reference value to produce an outcome including a likelihood that a target user will benefit from a target resource. Upon identifying the target user, a dynamic reallocation process deallocates the target resource from another user and reallocates the target resource to the target user.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G09B 5/14 - Electrically-operated educational appliances providing for individual presentation of information to a plurality of student stations with provision for individual teacher-student communication
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G09B 5/12 - Electrically-operated educational appliances providing for individual presentation of information to a plurality of student stations different stations being capable of presenting different information simultaneously
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
42 - Scientific, technological and industrial services, research and design
Goods & Services
Platform as a service (PAAS) featuring computer software platforms for researchers to access, share and store clinical research data and biomedical research data, and to run analytical tools
A wearable blood pressure meter includes a semi-conformable bladder, serving as a reservoir for an incompressible fluid, and a pressure sensor. The semi-conformable bladder includes a rigid housing defining a cavity within which the incompressible fluid is rigidly constrained and an elastic membrane for elastically constraining the incompressible fluid. The elastic membrane extends across an aperture into the cavity through the rigid housing. The elastic membrane conforms to a body part at the aperture when pressed against the body part. The pressure sensor mechanically couples to the incompressible fluid to measure pressure signals emanating from an artery within the body part and which propagate through the conformable membrane and the incompressible fluid to the pressure sensor.
A wearable blood pressure meter includes a semi-conformable bladder, serving as a reservoir for an incompressible fluid, and a pressure sensor. The semi-conformable bladder includes a rigid housing defining a cavity within which the incompressible fluid is rigidly constrained and an elastic membrane for elastically constraining the incompressible fluid. The elastic membrane extends across an aperture into the cavity through the rigid housing. The elastic membrane conforms to a body part at the aperture when pressed against the body part. The pressure sensor mechanically couples to the incompressible fluid to measure pressure signals emanating from an artery within the body part and which propagate through the conformable membrane and the incompressible fluid to the pressure sensor.
A disclosed method includes receiving at least an indication of audio data generated based on sound captured by a microphone of a monitoring device. A set of audio event labels are generated by processing the received audio data with a model that includes audio recognition patterns. Each audio event label is generated by matching an audio pattern in the received audio data with an audio pattern of the audio recognition patterns. The method further includes identifying a hazard event type occurring within a time window of the time period by processing the set of audio event labels with a hazard detection model. In response to detecting the hazard event type, a hazard alert is generated and at least an indication of the hazard alert is communicated to an electronic device other than the monitoring device, which is authorized to receive communications from the monitoring device.
Introduced here are diabetes management platforms able to guide people with diabetes toward a glycemic target. Rather than state the absolute amount of glucose within the blood, the diabetes management platform can instead produce personalized glycemic goals based on the physiological data associated with an individual. For example, if the diabetes management platform determines that the time spent within a first glycemic range exceeds a specified threshold, then the diabetes management platform may recommend that the individual attempt to keep their blood glucose level within a second glycemic range. Generally, the second glycemic range is closer than the first glycemic range to a target glycemic range corresponding to a healthy glycemic state.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
55.
BIOCOMPATIBLE ELECTROMECHANICAL CONNECTION FOR CERAMIC SUBSTRATE ELECTRONICS FOR BIOMEDICAL IMPLANT
A biocompatible electrical connection includes a substrate; a ferrule having a concentric flange at a first end of the ferrule; a first adhesive; and a second adhesive. The first adhesive adheres a first surface of the concentric flange of the ferrule to a surface of the substrate. The second adhesive fills an annular space between a hole in the substrate and the ferrule. The first adhesive or the second adhesive forms a conductive path on the surface of the substrate between the ferrule and a circuit pattern on the substrate.
H01R 4/60 - Connections between or with tubular conductors
H01R 43/02 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for soldered or welded connections
H05K 3/00 - Apparatus or processes for manufacturing printed circuits
H05K 3/32 - Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits
H05K 1/18 - Printed circuits structurally associated with non-printed electric components
H01R 4/04 - Electrically-conductive connections between two or more conductive members in direct contact, i.e. touching one another; Means for effecting or maintaining such contact; Electrically-conductive connections having two or more spaced connecting locations for conductors and using contact members penetrating insulation using electrically conductive adhesives
H01Q 1/27 - Adaptation for use in or on movable bodies
H01Q 23/00 - Antennas with active circuits or circuit elements integrated within them or attached to them
H01R 12/53 - Fixed connections for rigid printed circuits or like structures connecting to cables except for flat or ribbon cables
56.
NETWORKED CONTAINERS DESIGNED TO PROMOTE COMPLIANCE WITH A MEDICATION REGIMEN
Introduced here are containers designed to promote compliance with regimens for administering the medications stored therein. These containers can facilitate the conveyance of information related to a regimen through the use of a non-written medium. A container may include one or more display elements configured to emit/reflect light to indicate when medication stored in the container should be administered. An example of a display element is a light-emitting diode (LED). Emittance/reflectance of the light by the display element(s) may be governed by a different clock signal than the clock signal used to determine whether doses of medication are due to be administered.
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G08B 5/36 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission using visible light sources
57.
COMPUTER IMPLEMENTED PROCESS CONTROL USING A COMPUTER INSTANTIATED MATHEMATICAL MODEL DEFINING SEQUENCE-BASED ANCHORING AND TIME-BASED ANCHORING BETWEEN NODES
A computer method of managing a workflow of scheduled nodes. The method comprises instantiating a computer instantiated mathematical model of workflow paths, wherein the mathematical model defines nodes to be scheduled, defines time-based anchors between the nodes, and sequence-based anchors between the nodes; for each workflow object, determining a workflow schedule for the workflow object by an application executing on a computer system, wherein the workflow schedule comprises a plurality of nodes and wherein the application determines the workflow schedule based on the time-based anchors and sequence-based anchors between nodes defined by the mathematical model; storing by the application context information about completion of the activities performed when performing the node associated with the workflow path of the workflow object; and changing the workflow schedule of the workflow object based on the context information about completion of the activities performed and based on the mathematical model.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
The present invention is directed to a wearable fitness and/or heart rate monitoring device which includes motion detecting sensor(s), a galvanic skin response (GSR) sensor, a user input interface, or any combination thereof. The device accounts for signal noise, produced when an individual passes thru varying exercise states, by filtering out the motion of the individual using a 3-axis accelerometer. The invention also provides for systems and methods of operating the monitor which extracts and/or stores true or correct heart rate values from the heartbeat waveform signal observed from a PPG.
Introduced here are health management platforms able to monitor changes in the health state of a subject based on the context of digital activities performed by, or involving, the subject. Initially, a health management platform can identify a physiological response by examining physiological data associated with a subject. Then, the health management platform can identify a stimulus presented by an electronic device that provoked the physiological response by examining contextual data associated with the subject. The contextual data may be in the form of a screenshot of a computer program in use by the subject during the physiological response. In some embodiments, the health management platform prompts the subject to specify whether the physiological response is a positive physiological response that resulted in an upward shift in health or a negative physiological response that resulted in a downward shift in health.
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
H04W 4/21 - Services signalling; Auxiliary data signalling, i.e. transmitting data via a non-traffic channel for social networking applications
G06V 20/40 - Scenes; Scene-specific elements in video content
G06V 40/20 - Movements or behaviour, e.g. gesture recognition
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for data analytics in the fields of drug discovery, personalized medicine and patient care pathways Providing data analytics and machine learning services in the fields of drug development, personalized medicine and patient care pathways; providing non-downloadable software for data analytics in the fields of drug discovery, personalized medicine and patient care pathways
In some embodiments, features related to inter-beat intervals (IBI) detected by a PPG sensor of a wearable device are extracted and provided to a cardiovascular classifier in order to detect likely instances of a cardiac condition such as atrial fibrillation. Some embodiments use features related to the entropy of the IBI data to improve the predictions generated by the cardiovascular classifier. In some embodiments, co-information between the IBI data and IBI data gathered from healthy and AF populations is determined in order to derive features that represent the probability that a given sample of IBI data represents AF or a normal sinus rhythm. In response to determining likely instances of AF based on these features, the wearable device may obtain clinically acceptable data, such as an ECG, to be transmitted to a separate device for review by a clinician.
A wireless power system for an implantable device is described. The system includes multiple inductive charging coils to increase an effective area for receiving an electromagnetic charging field from a wireless charging device. The multiple inductive charging coils produce different alternating current signals in response to receiving the electromagnetic charging field. The system includes a rectifying circuit for rectifying the alternating current signals into direct current signals. The system also includes a current combination circuit for combining the multiple direct current signals into a single direct current for powering an operation of the implantable device. Methods and devices for implementing the power system in an implantable device are also described.
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
64.
Wearable electronic device including an overlapping communications antenna
A wearable electronic device is described. The wearable electronic device includes two communications antennae. A first antenna of the two is a current-carrying antenna electrically and physically connected to a printed circuit board of the wearable electronic device and housed in a first portion of a housing that is configured for mounting on a person's skin. A second antenna of the two is a scatterer antenna physically connected to an interior surface of a second portion of the housing and configured to overlap a portion of the current-carrying antenna. The second portion of the housing faces away from the person's skin when the wearable device is mounted on the person's skin. Current from the current-carrying antenna is induced in the scatterer antenna to enable communications between the wearable electronic device and one or more other electronic devices.
H01Q 1/27 - Adaptation for use in or on movable bodies
H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop
H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support
H01Q 9/16 - Resonant antennas with feed intermediate between the extremities of the antenna, e.g. centre-fed dipole
H01Q 1/22 - Supports; Mounting means by structural association with other equipment or articles
A method for tagging and organizing data is provided. In one example, physiological data detected from a wearer of a wearable device is received and associated with a tag based, at least in art, on an input by the wearer. The input may be a state of the wearer, such as physical or mental state, or a rule. The collected physiological data may be organized based on the tag and, in some examples, on other types of received data, such as a wearer's personal data. In other example methods, data may be stored in a database based on one or more tags associated with the data.
G06F 16/28 - Databases characterised by their database models, e.g. relational or object models
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
One example method for improving robotic surgical safety via video processing includes identifying, during a robotic surgical procedure, one or more surgical tools using one or more images of the surgical procedure captured by a camera, the robotic surgical procedure employing a robotic surgical device controlling the one or more identified surgical tools; predicting, for at least one of the one or more images, one or more loaded surgical tools that are controlled by the robotic surgical device and should be in a field of view of the camera; comparing the one or more identified surgical tools with the one or more loaded surgical tools; determining that at least one of the one or more loaded surgical tools does not match any of the one or more identified surgical tools; and causing the at least one loaded tool of the robotic surgical device to be disabled.
A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for clinical trial data collection, storage and analysis Providing online non-downloadable software for conducting clinical trials, including software for recruiting clinical trial participants, managing clinical trials, and collecting, storing and analyzing clinical trial data
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for facilitating image capture for medical screening and diagnostic purposes; downloadable computer software for facilitating screening, diagnosis and characterization of disease based on images Medical devices, namely, image capturing devices for screening, diagnosis and characterization of disease Providing online non-downloadable computer software for image-based medical screening, diagnostic and disease characterization purposes
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory services for testing wastewater for pathogens; providing information and analysis of epidemiological information and data pertaining to pathogens in wastewater
42 - Scientific, technological and industrial services, research and design
Goods & Services
Platform as a service (PAAS) featuring computer software for biomedical researchers to process, store and share data, run analysis tools and collaborate; providing temporary use of non-downloadable cloud-based computer software for collecting, processing, analyzing, transmitting, validating and displaying data in the medical, scientific and pharmaceutical fields
71.
Pulsed light imaging using rolling shutter image sensors
An imaging system and method for imaging a scene using a rolling shutter are described. In an embodiment, the method includes illuminating a scene with first and second illumination light; generating frame signals with a photodetector comprising a plurality of pixels arranged in a plurality of rows, wherein the frame signals are based on light received from the scene with sequentially integrated rows of pixels of the plurality of rows, and wherein a frame signal includes signals from pixels of each of the plurality of rows; and generating images of the scene based on an intensity of the frame signals and the proportion of the first illumination light and the second illumination light emitted onto the scene during the first and second frames, wherein a proportion of the first illumination light and the second illumination light in a first frame is different than in a second frame.
The present disclosure is related to a method of producing a microfluidic sorting apparatus. The method includes providing an injection-molded substrate comprising a network of channels; bonding an insulating film to an upper surface of the substrate to cover the network of channels; and depositing a conductive film on the insulating film. The substrate can be separated from the conductive film.
The present disclosure relates to implantable neuromodulation devices and methods of fabrication, and in particular to anatomically contoured spinal cord stimulation leads for high density neural interfaces and methods of microfabricating the stimulation leads. Particularly, aspects are directed to a thin film lead assembly that includes a cable having: a first supporting structure formed of dielectric material, a first set of conductive traces formed on the first supporting structure, a second supporting structure formed of dielectric material, and a second set of conductive traces formed on the second supporting structure. The thin film lead assembly also includes an electrode assembly having: a third supporting structure formed of dielectric material, a first set of electrodes in electrical connection with the first set of conductive traces, and a second set of electrodes in electrical connection with the second set of conductive traces.
A droplet sorting device is described. The droplet sorting device includes a primary channel, a sorting channel, a sorting electrode, a ground film, and an insulating layer. The sorting channel may intersect the primary channel to define a sorting junction. The sorting electrode may be disposed in a first plane adjacent to the sorting junction. The ground film may be disposed in a second plane that is different from the first plane. The insulating layer may be disposed in a third plane that is located between the first and second planes.
Introduced here are health management platforms able to infer the health state of a subject based on behavioral changes reflected in the digital activities performed by a subject. A health management platform can initially acquire contextual data pertaining to digital activities performed by the subject. The health management platform can identify the target(s) of the digital activities by parsing the contextual data, and then compile the digital activities and corresponding activities into a personalized valence index. Thereafter, the health management platform can compare digital activities performed by the subject to the entries included in the personalized valence index. If a matching entry is not discovered, the health management platform can identify an instance of behavior change. These instances of behavior change may be indicative of changes in the subject's health state.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Systems and methods for specular reflection reduction in endoscope visualizations are described. A method includes receiving an image including a region of specular reflection. The method includes detecting the region of specular reflection in the image. The method includes estimating image information for a portion of the region of specular reflection. The method also includes reconstructing the image including the image information populated into the region of specular reflection.
A user-interface for aiding navigation of an endoscope through a lumen of a tubular anatomical structure during an endoscopy procedure includes a video region in which a live video feed received from the endoscope is displayed and an observation location map. The observation location map depicts a point of observation from which the live video feed is acquired within the lumen relative to a cross-sectional depiction of the lumen as the endoscope longitudinally traverses the tubular anatomical structure within the lumen during the endoscopy procedure.
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Embodiments of a system, a machine-accessible storage medium, and a computer-implemented method are described in which operations are performed. The operations comprising receiving a plurality of image frames associated with a video of an endoscopy procedure, generating a probability estimate for one or more image frames included in the plurality of image frames, and identifying a transition in the video when the endoscopy procedure transitions from a first phase to a second phase based, at least in part, on the probability estimate for the one or more image frames. The probability estimate includes a first probability that one or more image frames are associated with a first phase of the endoscopy procedure.
The present disclosure relates to mapping catheters, and in particular to mapping catheters having thin film electrodes used in sensing electrical activity within a patient. Particularly, aspects of the present disclosure are directed to a medical device having a hollow core, a balloon disposed over at least a portion of the hollow core, and a flexible framework having one or more thin film elements formed on at least a portion of the balloon. The one or more thin film elements comprise a plurality of mapping electrodes.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
80.
USER-INTERFACE WITH NAVIGATIONAL AIDS FOR ENDOSCOPY PROCEDURES
A user-interface for aiding navigation of an endoscope through a lumen of a tubular anatomical structure during an endoscopy procedure includes a video region in which a live video feed received from the endoscope is displayed and an observation location map. The observation location map depicts a point of observation from which the live video feed is acquired within the lumen relative to a cross-sectional depiction of the lumen as the endoscope longitudinally traverses the tubular anatomical structure within the lumen during the endoscopy procedure.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
G06T 11/20 - Drawing from basic elements, e.g. lines or circles
A user-interface for visualizing a colonoscopy procedure includes a video region and a navigational map upon which coverage annotations are displayed. A live video feed received from a colonoscope is displayed in the video region. The navigational map depicts longitudinal sections of a colon. The coverage annotations are presented on the navigation map and indicate whether one or more of the longitudinal sections is deemed adequately inspected or inadequately inspected during the colonoscopy procedure.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Embodiments of a system, a machine-accessible storage medium, and a computer-implemented method are described in which operations are performed. The operations comprising receiving a plurality of image frames associated with a video of an endoscopy procedure, generating a probability estimate for one or more image frames included in the plurality of image frames, and identifying a transition in the video when the endoscopy procedure transitions from a first phase to a second phase based, at least in part, on the probability estimate for the one or more image frames. The probability estimate includes a first probability that one or more image frames are associated with a first phase of the endoscopy procedure.
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
83.
SYSTEMS AND METHODS FOR SCENE-ADAPTIVE IMAGE QUALITY IN SURGICAL VIDEO
One example method for scene-adaptive image quality in surgical video includes receiving a first video frame from an endoscope, the first video frame generated from a first raw image captured by an image sensor of the endoscope and processed by an image signal processing (“ISP”) pipeline having a plurality of ISP parameters; recognizing, using a trained machine learning (“ML”) model, a first scene type or a first scene feature type based on the first video frame; determining a first set of ISP parameters based on the first scene type or the first scene feature type; applying the first set of ISP parameters to the ISP pipeline; and receiving a second video frame from the endoscope, the second video frame generated from a second raw image captured by the image sensor and processed by the ISP pipeline using the first set of ISP parameters.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
84.
SPECULAR REFLECTION REDUCTION IN ENDOSCOPE VISUALIZATION
Systems and methods for specular reflection reduction in endoscope visualizations are described. A method includes receiving an image including a region of specular reflection. The method includes detecting the region of specular reflection in the image. The method includes estimating image information for a portion of the region of specular reflection. The method also includes reconstructing the image including the image information populated into the region of specular reflection.
One example method for scene-adaptive image quality in surgical video includes receiving a first video frame from an endoscope, the first video frame generated from a first raw image captured by an image sensor of the endoscope and processed by an image signal processing ("ISP") pipeline having a plurality of ISP parameters; recognizing, using a trained machine learning ("ML") model, a first scene type or a first scene feature type based on the first video frame; determining a first set of ISP parameters based on the first scene type or the first scene feature type; applying the first set of ISP parameters to the ISP pipeline; and receiving a second video frame from the endoscope, the second video frame generated from a second raw image captured by the image sensor and processed by the ISP pipeline using the first set of ISP parameters.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
H04N 5/445 - Receiver circuitry for displaying additional information
86.
Separable High Density Connectors For Implantable Device
The present disclosure relates to implantable neuromodulation devices and methods of fabrication, and in particular to a separable high density connectors for implantable neuromodulation devices. Particularly, aspects of the present disclosure are directed to a medical device comprising an electronics module and a header for connecting the electronics module to a lead assembly. The header includes: a housing that includes (i) a cavity having a central axis or plane and an internal surface, and (ii) an opening aligned with the central axis or plane of the cavity, an array of retractable contacts extending from the internal surface towards the central axis or plane of the cavity, and an array of connection terminals on the housing, where each connection terminal of the array of connection terminals is: (i) electrically connected to the electronics module, and (ii) electrically connectable to a retractable contact of the array of retractable contacts.
Eye cups and retinal imaging systems including an eye cup are described. In an embodiment, the eye cup is shaped to couple with an eyepiece lens assembly. In an embodiment, the eye cup includes a concave socket shaped to couple to a periorbital region of an eye, the concave socket defining a viewing aperture positioned to align with a pupil of the eye along a longitudinal axis of the viewing aperture when the concave socket is coupled to the periorbital region; and a flange extending from the concave socket away from the longitudinal axis and shaped to couple with a lateral margin of the periorbital region when the concave socket is coupled to the periorbital region. In an embodiment, an outer edge of the flange extends farther from the longitudinal axis than an outer edge of portion of the concave socket.
A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
88.
Systems And Methods For Sealing And Providing Wireless Power To Wearable Or Implantable Devices
One example device includes a first housing portion defining a first coupling surface; a second housing portion defining a second coupling surface, the first housing portion coupled to the second housing portion to form a housing, the first housing portion and the second housing portion defining an opening, the opening intersecting the first coupling surface and the second coupling surface; a first gasket positioned between the first coupling surface and the second coupling surface, the first gasket providing a first seal between the first housing portion and the second housing portion, a printed circuit board (“PCB”) disposed within the housing and coupled to at least one of the first or second housing portions; an electrical connector electrically coupled to the printed circuit board and positioned within the opening; and a second gasket positioned between the electrical connector and the housing, the second gasket providing a second seal between the electrical connector and the housing, wherein the first gasket is positioned to abut the second gasket and wherein compression of the first gasket between the first and second housing portions provides a third seal between the first gasket and the second gasket. Another example device includes a wireless field driver comprising a first antenna coil and an electrical current source electrically coupled to the first antenna coil; an electromagnetic field (“EMF”) sensor comprising a second antenna coil, wherein the EMF sensor is configured to generate a sensor signal indicative of a signal strength from the first antenna coil; a non-transitory computer-readable medium; and a processor in communication with the non-transitory computer-readable medium, the processor configured to execute processor-executable instructions stored in the non-transitory computer-readable medium to: cause the electrical current source to output a current to the first antenna coil to generate a first EMF; estimate the signal strength of the first EMF based on the sensor signal; and adjust the current to the first antenna coil based on an estimated signal strength of the first EMF to maintain a power characteristic and generate a second EMF at the first antenna coil.
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/60 - Circuit arrangements or systems for wireless supply or distribution of electric power responsive to the presence of foreign objects, e.g. detection of living beings
89.
Two-phase deployment-initiated wakeup mechanism for body-mountable electronic device
The technology described herein is related to a two-phase deployment-initiated wakeup mechanism for a body-mountable electronic device. During a first phase of the two-phase wakeup mechanism, a motion sensor detects an acceleration event indicative of deployment of the device onto the body of the user. During a second phase of the two-phase mechanism, control circuitry can be adapted to be enabled by the acceleration event. Once enabled, the control circuitry can verify that the device has been launched onto the body of a user via a deployment applicator in which the device is retained until deployment. Once verified, the control circuitry can wake up the body-mountable electronic device by transitioning the device from a sleep state to a functional (or operational) state.
The present disclosure relates to implantable neuromodulation devices, and in particular to a wireless power coil in a low profile environment such as with a neurostimulator. Particularly, aspects of the present disclosure are directed to a medical device that comprises a lossy housing surrounding a power supply, and a receiving coil configured to exchange power wirelessly via a wireless power transfer signal and deliver the power to the power supply. The receiving coil is adjacent the lossy housing. The receiving coil is a helical structure with a total rise that is less than or equal to a height of the lossy housing.
A retinal camera system comprises an eyepiece lens disposed within a housing, a retinal image sensor, and a visual guidance indicator. The retinal image sensor is adapted to acquire a retinal image of an eye through the eyepiece lens. The visual guidance indicator is disposed in or on the housing peripherally about the eyepiece lens. The visual guidance indicator is positioned and oriented relative to the eyepiece lens to emit a visual cue along an optical path that does not pass through the eyepiece lens. The visual cue is adapted to facilitate alignment of the eye to the eyepiece lens.
A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
A61B 3/18 - Arrangement of plural eye-testing or -examining apparatus
92.
SYSTEMS AND METHODS FOR REMOTE CLINICAL EXAMS AND AUTOMATED LABELING OF SIGNAL DATA
A user device may automatically identify activities that correspond to virtual motor exam tasks and clinical tasks and auto annotate sensor data based on previous annotations and machine-learning models trained using the same. The annotations may describe context, performance, subjective, and objective information related to the performance of the activity for tracking disease or treatment progression.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
A retinal imaging system includes an eyepiece lens assembly, an image sensor, a dynamic fixation target viewable through the eyepiece lens assembly, and a controller coupled to the image sensor and the dynamic fixation target. The controller includes logic that causes the retinal imaging system to perform operations including: acquiring a first image of the eye, analyzing the first image to determine whether a misalignment between the eye and the eyepiece lens assembly is present; in response to determining the misalignment is present, adjusting a visual position of the dynamic fixation target to encourage the eye to rotate in a direction that compensates for the misalignment, and acquiring the retinal image of the eye after adjusting the visual position of the dynamic fixation target.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
Techniques are disclosed for detecting a presence of a biological substance through an article such as a diaper. For example, a detection system causes a light source to transmit light through the article. The light includes a peak wavelength that corresponds to an excitation wavelength of a biological substance that may be present in the article. The detection system detects a measurement of light intensity within a range of emission wavelengths of the biological substance. By comparing the measurement of light intensity to a threshold, the detection system identifies a presence of the biological substance on the article.
A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
G01V 8/12 - Detecting, e.g. by using light barriers using one transmitter and one receiver
The present disclosure relates to branched proximal connectors for high density neural interfaces and methods of microfabricating the branched proximal connectors. Particularly, aspects of the present disclosure are directed to a branched connector that includes a main body having a base portion of a supporting structure and a plurality of conductive traces formed on the base portion, and a plurality of plugs extending from the main body. Each plug of the plurality of plugs include an end portion of the supporting structure comprised of the one or more layers of dielectric material, and a subset of conductive traces from the plurality of conductive traces. Each trace from the subset of conductive traces terminates at a bond pad exposed on a surface of the end portion of the supporting structure.
An apparatus, system and process for guiding a surgeon during a medical procedure to prevent surgical mistakes are described. The system may include a machine learning medical procedure server that generates one or more machine learning medical procedure models using, at least, medical procedure data captured during medical procedures performed at a plurality of different medical procedure systems. The system may also include a medical procedure system communicably coupled with the machine learning medical procedure server that receives a selected machine learning medical procedure model from the machine learning medical procedure server, and utilizes the selected machine learning medical procedure model during a corresponding medical procedure to control one or more operations of the medical procedure system.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
Introduced here are diabetes management platforms able to make annotations to physiological data of a subject whose glycemic health state is being monitored. These annotations can be used to classify excursions detected in the physiological data to facilitate the identification of a therapeutic behavior change intended to improve the glycemic health state of the subject. For example, a health coach may review the annotation(s) associated with the subject before generating a recommendation for improving the glycemic health state. As another example, the diabetes management platform can automatically identify an appropriate recommendation based on the annotation(s).
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
Image guided surgery includes capturing a primary modality image of a surgical field of a patient with a camera system, obtaining a secondary modality image of the surgical field registered to the primary image, generating a surgical guidance image based at least in part upon the secondary modality image, and projecting the surgical guidance image onto the patient. The surgical guidance image presents visual augmentations on or over the patient to inform a medical practitioner during a surgical procedure.
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
99.
Virtual health coach based insulin titration platform
The disclosed embodiments include a computer-implemented method for improving efficacy of diabetes self-management with automated personalized computer engagement that reliably obtains a measurement message and/or contextual information used to determine a suitable insulin dosage of an insulin titration process to treat the diabetic patient. The method includes causing display of a messaging interface that couples the user of the computing device to a chat bot simulating a health coach in a natural conversation to obtain a measurement of the diabetic patient's blood-glucose level. The method includes determining an insulin dosage recommendation to treat the diabetic patient by processing the measured blood-glucose level with an insulin titration algorithm that is personalized for the diabetic patient, and generating an electronic signal configured to cause a corresponding action to be performed by a computing device (e.g., display message of recommended insulin dosage).
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
H04L 51/02 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
An insect sortation system includes a first puff system in a puff-back region for moving insects toward an inlet of an insect pathway and a second puff system in a puff-forward region for moving insects toward an outlet of the pathway. The first puff system is configured to singulate the insects. The second puff system is configured to sort the insects.
