Abrégé

Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.

Classes IPC  ?

• C08F 222/12 - Esters de phénols ou d'alcools saturés
• C08F 122/20 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle
• C07C 57/04 - Acide acrylique; Acide méthacrylique
• C07C 69/54 - Esters d'acide acrylique; Esters d'acide méthacrylique
• A61K 31/78 - Polymères contenant de l'oxygène d'acide acrylique ou de ses dérivés

Abrégé

Disclosed is a laser system including a first laser and a second laser. The first laser includes a laser cavity, and a gas phase molecular gain medium disposed in the laser cavity, the gain medium having an absorption band. The second laser is a solid state laser configured to be continuously tunable, with respect to an emission wavelength of the second laser, over the absorption band of the gain medium, and the second laser is tuned to pump rotational vibrational transitions in the gain medium to achieve a rotational population inversion.

Classes IPC  ?

• H01S 3/0941 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p.ex. par une diode laser
• H01S 3/14 - Lasers, c. à d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet caractérisés par le matériau utilisé comme milieu actif
• H01S 3/22 - Lasers, c. à d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet caractérisés par le matériau utilisé comme milieu actif à gaz
• H01S 3/223 - Lasers, c. à d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet caractérisés par le matériau utilisé comme milieu actif à gaz le gaz actif étant polyatomique, c. à d. contenant plusieurs atomes
• H01S 5/00 - Lasers à semi-conducteurs

Abrégé

A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end and a non-contact optical connection arranged at an end of the rail body and configured to interface with a corresponding non-contact optical interface. A low speed data bus segment extends between the receiver end and the muzzle end of the rail body. A high speed data spoke is connected to the non-contact optical connection for high speed data communication with a high speed data accessory through the non-contact optical connection and the corresponding noncontact optical interface. Tactical rail systems and firearm assemblies having tactical rails are also described.

Classes IPC  ?

• F41G 11/00 - APPAREILS DE VISÉE; POINTAGE - Parties constitutives des appareils de pointage ou de visée; Accessoires
• F41C 27/00 - ARMES À FEU INDIVIDUELLES; ACCESSOIRES POUR CES ARMES - Détails ou organes adaptables, non prévus ailleurs

Abrégé

222 measurements are transformed into a novel metric known as Accumulated Hypoxic Debt (AHD). The AHD metric is used as the independent variable in a longitudinal generalized linear mixed model to calculate the probability D that the subject is at risk of AMS. Based on the probability D, appropriate courses of action may be communicated to the subject via the output device of a wearable or portable monitor.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale
• A61B 5/22 - Ergométrie; Mesure de la force musculaire ou de la force d'un coup musculaire
• A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents

Abrégé

Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components.

Classes IPC  ?

• C22C 21/00 - Alliages à base d'aluminium
• E21B 23/06 - Appareils pour déplacer, mettre en place, verrouiller, libérer ou retirer, les outils, les packers ou autres éléments dans les trous de forage pour le montage des packers
• E21B 33/12 - Packers; Bouchons

Abrégé

An apparatus for improving dexterity of the bare hands in cold temperatures includes heating pads 10 disposed on the forehead, cheeks and forearms. The heating pads 10a, 10b, 10c on the forehead and cheeks stimulate the trigeminal nerve area to increase blood flow to the fingers. The heating pads 10d, 10d on the forearms 24, 24 increase the temperature of the blood flowing to the hands. Thermocouples 32 in each heating pad 10 are connected to a set- point controller 28.

Classes IPC  ?

• A41D 13/005 - Vêtements protecteurs de travail ou de sport, p.ex. blouses de chirurgien ou vêtements protégeant des coups ou des chocs avec des conditions d'environnement interne qui sont commandées avec une température commandée
• A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain

Abrégé

Disclosed herein are methods of making attenuated Arenaviruses, compositions comprising the attenuated Arenaviruses, and methods of using the attenuated Arenaviruses. As disclosed herein, the attenuated Arenaviruses have a deletion of at least a portion of the intergenic region (IGR) of one or both genome segments.

Classes IPC  ?

• C12R 1/92 - Virus
• C07K 14/08 - Virus à ARN
• C12N 15/86 - Vecteurs viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C12N 7/01 - Virus, p.ex. bactériophages, modifiés par l'introduction de matériel génétique étranger
• A61K 35/76 - Virus; Particules sous-virales; Bactériophages

Abrégé

An apparatus (8) for isolating corneal endothelial cells (34) (CECs) includes a base portion (10) having an interior recessed opening (14) with a bottom surface (16). A convex projection (18) is centrally located on the bottom surface (16) and is configured to receive an inverted cornea (32). A top portion (12) is configured to mate with the base portion (10). The top portion (12) includes a fluid chamber (24) with a lower surface (20). The lower surface (20) has an opening (22) therein in which the convex projection (18) projects when the top portion (12) is mated with the base portion (10).

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

An airway management device (10) for a human or animal subject (20) includes an airway tube (101) having a first end for disposal external to the subject (20) and a second end (102) for disposal in a portion of an airway of the subject (20). A light emitting element (108) and a photosensing element (109) may be disposed at the second end (102) of the airway tube (101). The light emitting element (108) may be configured to transmit light to tissue adjacent to the light emitting element (108). The photosensing element (109) may be configured to receive reflectance spectra (204) from the tissue. The location of the second end (102) of the airway tube (101) may be determined from characteristics of the reflectance spectra (204) of the tissue.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
• A61B 1/267 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments pour les voies respiratoires, p.ex. laryngoscopes, bronchoscopes
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires

Abrégé

Brain impairment, for example due to stroke, is corrected in order to improve body movement. An fNIRS device is positioned over the motor cortex of non-impaired individuals, and blood oxygen in locations of the brain is analyzed to determine brain activity corresponding to a particular body movement. The movements are statistically analyzed, and are compared with fNIRS data gathered from a movement impaired individual attempting the same movement. A weighted value corresponding to the desired brain activity is generated using the statistical analysis, and is graphically displayed to the movement impaired individual during the attempts. This produces a feedback loop relating to the movement which can be repeated to produce brain plasticity in the impaired individual to facilitate the movement. Additionally, correct brain activity can be used to cause the application of an electrical signal to muscles of the body to produce the desired movement.

Classes IPC  ?

• A61B 5/0482 - Electro-encéphalographie utilisant une rétroaction biologique
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
• A63B 21/00 - Appareils de gymnastique pour développer ou fortifier les muscles ou les articulations du corps en surmontant des résistances, avec ou sans dispositifs de mesure
• A63B 24/00 - Commandes électriques ou électroniques pour les appareils d'exercice des groupes
• G01N 21/35 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• G06K 9/40 - Filtrage du bruit

Abrégé

Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL).

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The invention relates to a method for preventing, ameliorating or treating disease caused by dengue vims in a subject in need thereof comprising administering to the subject a dengue vaccine formulation in combination with a NS3 helicase polypeptide and/or fragment(s) thereof, wherein said method comprises stimulating humoral as well as cell- mediated immunity to the dengue virus in the subject,

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• C07K 1/00 - Procédés généraux de préparation de peptides
• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide

Abrégé

The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/12 - Antigènes viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

An apparatus (18) for mounting surgical rails (40, 42) to a litter (10) having a pair of parallel poles (12) includes a pair of longitudinal members (20, 22) fixed to outboard sides of respective ones of the pair of poles (12). A pair of surgical rails (40, 42) is fixed to outboard surfaces of respective ones of the pair of longitudinal members (20, 22). Clamps (24, 26, 28, 30) at each end of each longitudinal member (20, 22) fix the longitudinal members (20, 22) to the pair of poles (12). A pair of cross bars (36, 38) extend between and are fixed to opposing clamps (24, 26, 28, 30) at each end of each longitudinal member (20, 22).

Classes IPC  ?

• A61G 1/04 - Brancards - Parties constitutives, détails ou accessoires, p.ex. appuis-tête, repose-pied, éléments d'appui ou analogues, spécialement adaptés aux brancards

Abrégé

An arthropod trap (10) includes a source (60) of CO2 gas. The CO2 gas is released proximate the arthropod trap (10). The source (60) of the CO2 gas includes an inflatable bladder (42) filled with breath (46) that was exhaled by a human being (100).

Classes IPC  ?

• A01M 1/02 - Systèmes fixes pour capturer ou détruire les insectes avec dispositifs pour attirer les insectes
• A01M 1/10 - Pièges

Abrégé

A computer-assisted surgical system can include a donor sub-system and a recipient sub¬ system. The donor sub-system includes a first reference unit having a first trackable element, a fragment reference unit having a second trackable element, and a first detector configured to provide at least one of a first signal corresponding to a detected location of one or more of the first trackable element and the second trackable element. The recipient sub-system includes a second reference unit having a third trackable element, and a second detector configured to provide at least one of a second signal corresponding to a detected location of at least the third trackable element.

Classes IPC  ?

• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
• A61B 17/16 - Ostéoclastes; Forets ou ciseaux pour os; Trépans
• A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
• A61F 2/28 - Os

Abrégé

Provided herein is a computer-implemented method, system, computer-readable medium operable to perform the method for cephalometry for orthognathic and craniomaxillofacial surgery. The method can include transforming a set of cephalometric landmarks from a donor or mobile skeletal fragment in a first reference frame to a second reference frame based on a registration process that maps coordinates from the first reference frame to coordinates in the second reference frame; tracking movement, based on one or more signals from one or more sensors, during surgery, of one or more of the cephalometric landmarks in the set of cephalometric landmarks associated with the donor or mobile skeletal fragment with respect to one or more of the cephalometric landmarks in the set of cephalometric landmarks associated with a recipient or second skeletal portion in the second reference frame; calculating one or more cephalometry metrics; and providing an update of the one or more cephalometry metrics.

Classes IPC  ?

• A61B 17/56 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulations; Dispositifs spécialement adaptés à cet effet
• A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
• A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic

Abrégé

A pelvic trauma device for emergency treatment of pelvic fracture includes two parallel elongated straps or belts that are connected, but are adjusted independently of each other. The two parallel belts include a lower belt and an upper belt. The two parallel belts are independently tensioned to provide: 1) pelvic fracture stabilization (lower belt); and 2) compression over the sacrum and anterior abdomen (upper belt).

Classes IPC  ?

• A61F 5/01 - Dispositifs orthopédiques, p.ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
• A61F 5/02 - Corsets orthopédiques
• A61F 13/02 - Emplâtres ou pansements adhésifs

Abrégé

his invention relates generally to the discovery of improved food-grade protein matrices with reduced allergeiiicity and uses thereof including immunotherapy.

Classes IPC  ?

• A23L 1/29 - Modification de la qualité nutritive des aliments; Produits diététiques ( A23L 1/09 a priorité;substituts diététiques du sel A23L 1/22)
• A23L 1/20 - Traitement des légumineuses, c. à d. des fruits de plantes légumineuses, pour l'obtention de fourrages ou d'aliments; Préparation de produits à partir de légumineuses; Moyens chimiques pour accélérer la cuisson de ces aliments, p.ex. traitement aux phosphates

Abrégé

A method and a system of estimating core temperatures of battery cells in a battery pack can include several steps. In one step, a surface temperature of one or more battery cell(s) is received, a current of the one or more battery cell(s) is received, an inlet temperature of coolant provided to the battery pack is received, and a flow rate or velocity of the coolant is received. In another step, estimations are made including those of a cell-lumped internal electrical resistance of the battery cell(s), a cell-lumped conduction resistance between a core and a surface of the battery cell(s), and a cell- lumped convection resistance between the surface and the coolant. In yet another step, an estimation is made of a core temperature of the battery cell(s) based upon the received and estimated values of previous steps.

Classes IPC  ?

• H01M 10/48 - Accumulateurs combinés à des dispositions pour mesurer, tester ou indiquer l'état des éléments, p.ex. le niveau ou la densité de l'électrolyte
• H01M 10/50 - Chauffage, refroidissement ou régulation de la température (commande de température en général G05D 23/00)

Abrégé

Methods for the synthesis of toeofiexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material

Classes IPC  ?

• A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle  avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle

Abrégé

A two person portable apparatus (10) for reducing the core temperature of one or more human beings includes a trough (14) made of a waterproof, flexible fabric (56) and a generally rectangular frame (12). Portions (68, 70, 72, 74) of the fabric (56) are looped over sides (24, 26, 28, 30) of the frame (12) so that the trough is supported by and suspended from the frame. The apparatus includes four legs (16, 18, 20, 22) hinged to corners of the frame and pivotable inwardly under the trough. Cooling water is placed in the trough and the hands and forearms of human beings are immersed in the cooling water.

Classes IPC  ?

• A47K 3/06 - Baignoires pliantes
• A61H 35/00 - Bains pour parties déterminées du corps, p.ex. douches pour la poitrine
• E04H 4/00 - Piscines ou pataugeoires

Abrégé

A macro photographic apparatus for creating focus stacked images of a specimen may include a rigid longitudinal member having a longitudinal axis and including a camera mount thereon. A translation device may be fixed to the member for translating the specimen along the member toward and away from the camera mount. A rotation device may be mounted on the translation device. The rotation device may support the specimen and enable rotation of the specimen around first and second axes that are perpendicular to the longitudinal axis of the member. At any single position of the translation device along the longitudinal axis of the member, as the specimen is rotated around the first and second axes, the spatial location of the specimen remains substantially the same.

Classes IPC  ?

• G02B 27/22 - Autres systèmes optiques; Autres appareils optiques pour produire des effets stéréoscopiques ou autres effets de relief
• G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette

Abrégé

This invention describes the preparation of a series of compounds that can be used as co-solvents, solutes or additives in non-aqueous electrolytes and their test results in various electrochemical devices. The inclusion of these novel compounds in electrolyte systems can enable rechargeable chemistries at high voltages that are otherwise impossible with state-of-the-art electrolyte technologies. These compounds are so chosen because of their beneficial effect on the interphasial chemistries formed at high potentials, such as 5.0 V class cathodes for new Li ion chemistries. The potential application of these compounds goes beyond Li ion battery technology and covers any electrochemical device that employs non-aqueous electrolytes for the benefit of high energy density resultant from high operating voltages.

Classes IPC  ?

• H01M 4/52 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer
• C01G 51/04 - Oxydes; Hydroxydes

Abrégé

Functionalized polymer matrix and/or reinforcement materials that are capable of a thermoreversible Diels-Alder reaction are useful for making composite materials. Also disclosed is a composite material which includes one or both of functionalized reinforcement materials and functionalized polymer matrix materials, as well as a method for repairing a composite material including the step of thermally treating the composite material at a temperature sufficient to react a functionality on one of the reinforcement material and the polymer matrix material with another functionality via a Diels-Alder reaction. A method of making a composite material including functionalizing one or both of a reinforcing material and a polymer matrix material with a first reactive group, providing a second reactive group capable of undergoing a Diels-Alder reaction with the first reactive group and reacting the first and second reactive groups to form a composite material, is also described.

Classes IPC  ?

• C08K 5/3415 - Cycles à cinq chaînons
• C08L 71/02 - Oxydes des polyalkylènes
• C08G 65/20 - Tétrahydrofuranne
• C08G 73/06 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale de la macromolécule; Polyhydrazides; Polyamide-acides ou précurseurs similaires de polyimides
• C07D 307/52 - Radicaux substitués par des atomes d'azote ne faisant par partie d'un radical nitro 

Abrégé

A hazardous materials protective garment may use a two-stage evaporative cooling process to ease heat strain on the wearer of the garment. The garment may include an impermeable inner layer and a wicking outer layer. One or more reservoirs may be disposed interior to the inner layer for collecting condensed and/or unevaporated sweat. One or more pumps may move the sweat to the exterior of the impermeable layer for distribution in the wicking layer and evaporation from the garment.

Classes IPC  ?

• A41D 13/005 - Vêtements protecteurs de travail ou de sport, p.ex. blouses de chirurgien ou vêtements protégeant des coups ou des chocs avec des conditions d'environnement interne qui sont commandées avec une température commandée
• A41D 13/02 - Combinaisons de travail ou de sport
• A41D 13/00 - Vêtements protecteurs de travail ou de sport, p.ex. blouses de chirurgien ou vêtements protégeant des coups ou des chocs

Abrégé

The present invention relates to an isolated anaerobic bacterium Bacteroides sp. for use as a fϊbro-biotic for livestock. More specifically, the fibro-biotic supplements a fiber diet to Sus scrofa scrofa with the fibro-biotic improving fiber digestion and decreasing fecal output in these livestock. The present invention also relates to the use of the isolated bacterium as a food composition to improve the health of monogastric livestock and as a feed supplement to livestock.

Classes IPC  ?

• C12N 1/20 - Bactéries; Leurs milieux de culture
• C12N 11/02 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique
• A23K 1/16 - additionnés d'éléments nutritifs accessoires; Blocs de sel
• C12R 1/01 - Bactéries ou actinomycètes

Abrégé

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Classes IPC  ?

• A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p.ex. de remèdes, dans les cavités du corps
• A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio

Abrégé

Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.

Classes IPC  ?

• A61K 31/47 - Quinoléines; Isoquinoléines
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p.ex. azélastine, pentylènetétrazole
• A61K 31/7052 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides 
• A61P 33/00 - Agents antiparasitaires
• A61P 33/02 - Antiprotozoaires, p.ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
• A61P 33/06 - Antipaludéens
• C07D 215/14 - Radicaux substitués par des atomes d'oxygène
• C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques

Abrégé

The present invention relates to a lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen derived from Hepatitis B.

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p.ex. antigènes de Plasmodium
• A61K 39/29 - Virus de l'hépatite

Abrégé

The present invention relates to a hybrid/ fusion protein derived from the CS protein of Plasmodium vivax (P. vivax), methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, for example those caused by P. vivax, compositions/vaccines containing the protein or antibodies against the protein such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. The invention also extends to lipoprotein particles of said hybrid protein and formulations/vaccines comprising the same and use thereof. In particular it relates to an immunogenic hybrid fusion protein comprising: a. at least one repeat unit derived from the repeating region of a type I circumsporozoite protein of P. vivax, b. at least one repeat unit derived from the repeating region of a type II circumsporozoite protein of P. vivax, and surface antigen S derived from Hepatitis B virus, or a fragment thereof

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p.ex. antigènes de Plasmodium
• A61K 39/29 - Virus de l'hépatite

Abrégé

A KE rod warhead for artillery rockets contains a multiplicity of KE rod penetrators (202) packaged into tier packs (104A, 104B, 104C) that are stacked and positioned around a center column (102) of the warhead. The warhead has a skin (105) that is severed when the rocket enters its target area. The KE rods (202) are situated and housed in such a manner that they experience a minimum of pitching or tumbling as they are released from the rocket and enter the airstream. As a result, the rods have optimum lethality against their target. The KE rod artillery rocket warhead contains no explosive munitions, so it can be used without contaminating the target area with unexploded ordnance.

Classes IPC  ?

• F42B 12/60 - Munitions en grappes ou munitions-cargo, c. à d. projectiles portant un seul ou plusieurs sous-projectiles les sous-projectiles étant éjectés radialement

Abrégé

Disclosed are lipids, annexin, and lipid-annexin complexes for use in the prevention and/or treatment of ischemia-reperfusion injury and reperfusion injury associated with a variety of diseases and conditions. Also disclosed are therapeutic targets and compositions for the prevention and treatment of ischemia-reperfusion injury and diseases and conditions associated with ischemia-reperfusion injury.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire

Abrégé

The Trajectory Correction Kit (101) is a completely self-contained retrofit kit that is externally and fixedly mounted as an add-on to the rear of an existing, unguided rocket. The TCK continuously measures the pitch and yaw of the rocket as it is released from the launch tube and during the initial seconds of the flight and calculates the trajectory correction that is necessary to eliminate the measured pitch and yaw. Then it activates selected thrusters among the thrusters (301, 401) that are positioned around the circumference of the rocket body (100) so as to steer the rocket in a direction until the measured pitch and yaw are eliminated.

Classes IPC  ?

• F41G 7/00 - Systèmes de commande de guidage pour missiles autopropulsés
• F42B 10/00 - Moyens pour influencer, p.ex. pour améliorer, les propriétés aérodynamiques de projectiles; Dispositions sur les projectiles pour la stabilisation, le pilotage, le freinage de la chute, la réduction ou l'augmentation de la portée

Abrégé

The present invention comprises a device which utilizes catalytic microcombustion for the production of heat or power and which exhibits a low pressure drop and has a high catalytic surface area. The catalytic microcombustor includes catalyst inserts in the reaction chamber separated by a sub millimeter distance. Thermal spreaders ensure temperature uniformity and maximum thermal efficiency. A mixing zone is prior to the combustion zone. Thermally conductive and/or insulating inserts are in the vicinity of the reaction zone.

Classes IPC  ?

• F02B 71/00 - Moteurs à pistons libres; Moteurs sans arbre principal rotatif

Abrégé

The invention relates to transcutaneous and/or transdermal transport of materials, such as antigens, drugs, drugs, nucleic acids, (e.g., DNA and RNA), proteins, other therapeutic agents, dyes, and the like, into the skin and/or the body. The material is transported transcutaneously and/or transdermally using an antigen presenting cell (APC) by applying the APC and the material on to the surface of the skin.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/38 - Antigènes de serpents
• A01N 1/02 - Conservation de parties vivantes
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/02 - Propagation de cellules individuelles ou de cellules en suspension; Leur conservation; Milieux de culture à cet effet