UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND CORK (Irlande)
Inventeur(s)
Moore, Tom
Waeber, Christian
Abrégé
The invention provides a Pregnancy-specific glycoprotein (for example PSG1) for use in a method of treating neurological disorders or stimulating survival or recovery of tissue damaged by a cerebrovascular event or brain trauma in a subject. The PSG1 may be Fc-tagged PSG1.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p.ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénal
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (Irlande)
Inventeur(s)
Moore, Tom
Clover, Anthony James Peterson
Abrégé
The use of Fc-tagged Pregnancy-specific glycoprotein 1 (PSG1-Fc) in a method of treatment of osteoarthritis or damaged cartilage in a human, in which the PSG1 is administered by intra-articular injection, is described. Also described is the use of CC49 in a method of treatment of osteoarthritis or damaged cartilage in an equine mammal, in which the CC49 is administered by intra-articular injection. (Fig. 3A-C) Also described is the use of PSG1 in a method of treatment of wounds, scarring, burns and diabetic ulcers in a mammal.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p.ex. arthrites, arthroses
3.
METHODS AND COMPOSITIONS USING COMBINATIONS OF LACTOBACILLUS MUCOSAE AND SOLUBLE DIETARY FIBER
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (Irlande)
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC) (Irlande)
Inventeur(s)
Caplice, Noel
Stanton, Catherine
Ross, Paul
Herisson, Florence
Karnik, Kavita
De Souza, Mervyn
Laurie, Ieva
Canene-Adams, Kirstie
Abrégé
The present disclosure provides compositions comprising Lactobacillus mucosae and soluble dietary fiber, and methods treatment related thereto, useful against metabolic syndrome and related diseases, disorders and morbidities.
A23L 29/269 - Aliments ou produits alimentaires contenant des additifs; Leur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine microbienne, p.ex. xanthane ou dextrane
A61K 35/747 - Lactobacilles, p.ex. L. acidophilus ou L. brevis
A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques
A23L 33/21 - Adjonction de substances essentiellement non digestibles, p.ex. de fibres diététiques
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK (Irlande)
Inventeur(s)
O'Toole, Paul
Jeffery, Ian
Ghosh, Tarini
Tan, Huizi
Perez, Marta
Ntemiri, Alexandra
Abrégé
A probiotic composition is provided comprising at least two isolated bacterial species or comprising a purified bacterial preparation comprising at least two bacterial species, wherein the at least two bacterial species are selected from the group consisting of Coprococcus catus, Eubacterium rectale, Alistipes putredinis, Barnesiella intestinihominis, Roseburia hominis, Dorea longicatena and Faecalibacterium prausnitzii. Also provided are specific isolated bacterial strains and use of the composition for treating frailty and/or inflammation related to aging in elderly subjects.
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (Irlande)
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC) (Irlande)
Inventeur(s)
Stanton, Catherine
Ross, Paul
Fitzgerald, Ger
Ryan, Tony
Abrégé
A composition comprises a cohort of at least five isolated unique strains of a single species of bacteria, wherein the species of bacteria is represented in the mammalian microbiome, and wherein the cohort of isolated strains exhibit different and diverse catabolic capability thereby increasing the chances that one or more of the strains in the composition will find a nutritional niche in the infant GI tract.
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND CORK (Irlande)
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC) (Irlande)
Inventeur(s)
Cryan, John
Dinan, Ted
Stanton, Catherine
Schellekens, Harriet
Torres, Cristina
Roy, Bernard
Abrégé
A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND CORK (Irlande)
Inventeur(s)
O'Brien, Peter Andrew
Duperron, Matthieu Francois Gabriel
Burke, Ray
Eason, Cormac James
Manley, Kevin
Nunan, Gerard
Abrégé
A surgical system for penetrating and determining a characteristic of tissue. An instrument generates rotational torque, and a drill bit tool body extends along an axis between a distal end to engage tissue and a proximal end to couple to the instrument. An emitter operatively coupled to the instrument emits light. A detector operatively coupled to the instrument detects light. An emission lightguide within the tool body transmits light emitted by the emitter toward the tissue as the instrument rotates the tool body. A detection lightguide within the tool body is spaced from the emission lightguide and transmit light reflected by the tissue toward the detector as the instrument rotates the tool body. The emitter emits light into the emission lightguide along the axis, and the detector detects light reflected from the tissue exiting the detection lightguide transverse to the axis when the tool body is coupled to the instrument.
A61B 17/16 - Ostéoclastes; Forets ou ciseaux pour os; Trépans
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
B23B 49/00 - Systèmes de mesure ou de calibrage des machines à aléser, pour le positionnement ou le guidage du foret; Dispositif pour indiquer les défauts des forets pendant l'alésage; Dispositifs à centrer les trous à aléser
8.
METHODS OF DETERMINING COLORECTAL CANCER STATUS IN AN INDIVIDUAL
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
brevets
