Abrégé

The inventors report in the present application the results of applying this innovative analytical approach on three independent EWASs for deriving and validating an epigenome score that exhibited a high diagnostic accuracy for detecting hepatocellular carcinoma (HCC). Indeed, they have performed in silico replication studies on two independent DNA methylome datasets using the 105 CpG probes of the HCC Epigenome Score. All the 13 loci were significantly associated with the HCC phenotype in both replication studies. Consistently, the random effect meta-analysis confirmed the significance of the 13 top loci. The inventors performed dose-response probit regression analysis to assess the association between the HCC Epigenome Score using the 586 samples. The HCC Epigenome score was significantly associated with the risk of HCC with a gradual increase in the risk of HCC according to the increase in the HCC Epigenome Score. Accordingly, the present invention relates to the use of a DNA methylation signature for diagnosing hepatocellular carcinoma in a subject.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The invention relates to a method for generating nanoparticles on the surface of a substrate, said method comprising: - a step of providing the substrate made of a material comprising at least one element from columns 4, 5, 13 and 14 of the periodic table, and at least one noble or transition metal; - a step of laser-irradiating the substrate with a pulse duration of between 1 fs and 100 ps, a fluence per pulse of between 0.01 J/cm2 and 100 J/cm2, a wavelength of between 100 nm and 5000 nm, and a number of pulses per point of between 1 and 1000; and - a step of generating at least one nanoparticle on the surface of the substrate, the at least one nanoparticle comprising at least the noble or transition metal, and having a chemical composition different from that of the substrate. The invention also relates to a part comprising such nanoparticles.

Classes IPC  ?

• B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaire; Appareils à cet usage utilisant des radiations électromagnétiques
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• B23K 26/062 - Mise en forme du faisceau laser, p.ex. à l’aide de masques ou de foyers multiples par commande directe du faisceau laser
• B23K 26/082 - Systèmes de balayage, c. à d. des dispositifs comportant un mouvement relatif entre le faisceau laser et la tête du laser
• B23K 26/352 - Travail par rayon laser, p.ex. soudage, découpage ou perçage  pour le traitement de surface
• B23K 26/00 - Travail par rayon laser, p.ex. soudage, découpage ou perçage 
• C21D 10/00 - Modification des propriétés physiques autrement que par traitement thermique ou déformation
• C22F 3/00 - Modification de la structure physique des métaux ou alliages non ferreux par des méthodes physiques particulières, p.ex. traitement par les neutrons
• C23C 14/14 - Matériau métallique, bore ou silicium
• C23C 14/16 - Matériau métallique, bore ou silicium sur des substrats métalliques, en bore ou en silicium
• C23C 14/35 - Pulvérisation cathodique par application d'un champ magnétique, p.ex. pulvérisation au moyen d'un magnétron
• C23C 14/58 - Post-traitement

Abrégé

The invention relates to a method for manufacturing a porous adsorbent coating, comprising the steps of: - obtaining a homogeneous mixture comprising water, mesoporous particles in which the grains have a diameter of less than 800 ?m and a reinforcement; - covering all or part of a component to be coated with a layer of homogeneous mixture; and - compressing the layer of mixture onto the component to be coated under a pressure of more than 10 bar.

Classes IPC  ?

• B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p.ex. acides humiques ou leurs dérivés
• B01J 20/32 - Imprégnation ou revêtement
• F25B 17/08 - Machines, installations ou systèmes à sorption, à marche discontinue, p.ex. à absorption ou à adsorption l'absorbant ou l'adsorbant étant un solide, p.ex. du sel
• F25B 37/00 - Absorbeurs; Adsorbeurs

Abrégé

The present invention relates to an ocular delivery system useful for the treatment of glaucoma. Especially, the invention provides a mucoadhesive ocular insert comprising a matrix of preactivated thiomer of hyaluronic acid and one or more anti-glaucoma drug.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament
• A61K 9/70 - Bases pour bande, feuille ou filament
• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• A61K 31/5575 - Eicosanoïdes, p.ex. leucotriènes ayant un cycle cyclopentane, p.ex. prostaglandine E2, prostaglandine F2-alpha
• A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine

Abrégé

The present invention relates to copper nanoclusters, characterised in that they: - are covered on their surface by a mixed layer comprising histidine (His), acetate ions (Ac) and optionally ascorbate ions (Asc), - are spherically shaped, - have a hydrodynamic diameter ranging from 0.6 to 2.0 nm, and preferably of 1.3 nm, - have a metal core diameter ranging from 0.5 to 1.5 nm, and preferably of 1.0 nm, - have a stability over time ranging from 5 to 12 weeks when the nanoclusters are in solution, - have a stability over time of at least 12 months, and preferably 12 to 18 months when the nanoclusters are in dry form, - have spectrophotometric properties, with a shoulder peak on the UV-visible spectrum at 325 ± 10 nm and a fluorescence spectrum with excitation wavelengths ranging from 365 to 395 nm and emission wavelengths ranging from 445 to 475 nm, the copper nanoclusters being denoted by the formula "CuNC@HisAc" or "CuNC@HisAcAsc". The invention further relates to a method for preparing copper nanoclusters. The invention further relates to copper nanoclusters for use in the treatment of copper deficiency-related diseases and, in particular, Menkes disease.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 33/34 - Cuivre; Ses composés
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

The invention relates to a facility for detecting at least one characteristic parameter of a medium (M), this detection facility (1) comprising means (3) for illuminating the medium (M) with a visible polychromatic light, means (4) for exciting the medium (M) with a visible-light or infrared monochromatic radiation, first means (5) for collecting and conveying at least a first electromagnetic radiation emitted by the medium (M), second means (6) for collecting and conveying at least a second electromagnetic radiation emitted by the medium (M), at least one visible-band spectrometer (7) for obtaining at least one visible-band spectrum of the medium (M) from said at least a first electromagnetic radiation, at least one Raman spectrometer (8) for obtaining at least one Raman spectrum of the medium (M) from said at least a second electromagnetic radiation, and means (9) for detecting said at least one characteristic parameter from said at least one visible-band spectrum and from said at least one Raman spectrum of the medium (M).

Classes IPC  ?

• G01N 21/65 - Diffusion de Raman

Abrégé

The present invention relates to an isolated double stranded DNA polynucleotide that forms triplex with sequence 5'-GGUGGCAGCAAGAGAAAAAUGAGGAAGAAGCAAAAGCGGAAA-3' (SEQ ID NO : 1) of the long non-coding RNA ANRIL (Antisense Non-coding RNA in the INK4 Locus). It also relates to a vector comprising the double stranded DNA polynucleotide, and to a pharmaceutical composition comprising the double stranded DNA polynucleotide or the vector. The present invention relates as well to the isolated double stranded DNA polynucleotide for use in the treatment of myocardial infarction, aneurysms, stenosis, myocardial infarction, aneurysms, cancers, eye diseases or type 2 diabetes.

Classes IPC  ?

• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

Abrégé

The invention relates to a method and system for assisting learning of endoscopic surgery, in particular endonasal surgery, during exercises each comprising a set of instrument movements of the endoscope (101) and/or of one or more surgical instruments (102), carried out by the operator. The system (1) comprises a hardware simulator (107) including one or more thematic models (100), in particular interchangeable modules (109) on a support head (108). It also comprises a computerised management unit (110) which communicates with the endoscope (101) and/or the instrument (102) and/or the module (109) or model (100). For each exercise, it displays the actions to be performed, and detects various endoscope and/or instrument movements and/or contacts. One module (2) presents targets to be visualised in a framed manner, the display of which is validated by shape recognition in the software. Other modules comprise objects to be dissected or moved, while avoiding obstacles. The prohibited or requested movements of instruments, grippers and/or contacts, are recorded by the software in order to evaluate the exercise.

Classes IPC  ?

• G09B 23/28 - Modèles à usage scientifique, médical ou mathématique, p.ex. dispositif en vraie grandeur pour la démonstration pour la médecine
• G09B 23/30 - Modèles anatomiques
• G09B 23/32 - Modèles anatomiques avec des parties mobiles

Abrégé

The present invention relates to the use of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a marker in a method for identifying a subject suffering from a disease caused by a coronavirus such as COVID-19 at risk of having or developing a severe form and/or a complication or at risk of death, in a method for assessing the severity of a disease caused by a coronavirus such as COVID-19, and in a method for monitoring a subject suffering from a disease caused by a coronavirus such as COVID-19.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present invention concerns new peptides derived from the netrin-like domain of the FRZB protein, that are useful in the prevention or treatment of Wnt/?-catenin and/or Hippo/YAP/TAZ pathway-related diseases, in particular of osteoarthritis.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The present invention relates to a flame retardant treatment of a lignocellulosic material, characterized in that it comprises the following steps: - optionally steam explosion of the lignocellulosic material, - impregnation of the optionally steam-exploded lignocellulosic material, in or with an aqueous solution comprising from 0.5% to 10% of phytic acid and from 1% to 30% of urea, and preferably from 3% to 7% of phytic acid and from 15% to 22% of urea, said percentages being expressed by weight relative to the total weight of the aqueous solution, - optionally drying of the impregnated lignocellulosic material, until it has a moisture content ranging from 5% to 20%, said percentages being expressed by weight relative to the total weight of the impregnated lignocellulosic material, - cooking of the impregnated and optionally dried lignocellulosic material, the resulting flame-retarded lignocellulosic material comprising a content of phosphorus originating from the phytic acid ranging from 0.1% to 10%, preferably ranging from 0.3% to 3%, said percentages being expressed by weight relative to the total weight of the flame-retarded lignocellulosic material. The invention also relates to the resulting flame-retarded lignocellulosic material and the use thereof for manufacturing: - flame-retarded composite materials based on plant fibres, - woven or nonwoven flame-retarded flexible materials based on plant fibres, and particularly textiles, - flame-retarded materials based on wood fibres and/or on wood particles, and particularly flame-retarded wood panels.

Classes IPC  ?

• B27K 3/02 - Procédés; Appareillage
• B27K 3/34 - Agents d'imprégnation organiques
• B27K 3/42 - Composés aromatiques nitrés, ou nitrés et halogénés
• B27K 3/50 - Mélanges de différents agents d'imprégnation organiques
• C07C 273/00 - Préparation d'urée ou de ses dérivés, c. à d. de composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
• C07F 9/117 - Esters des acides phosphoriques avec des alcools cycloaliphatiques
• C08L 97/02 - Matériau lignocellulosique, p.ex. bois, paille ou bagasse
• C09K 21/00 - Substances ignifugeantes
• D06M 13/00 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés organiques non macromoléculaires; Un tel traitement combiné avec un traitement mécanique

Abrégé

The present application relates to a protein capable of converting chlorogenic acid into isochlorogenic acid, said protein comprising or consisting of an amino acid sequence SEQ ID No. 1, a sequence having at least 80% identity with this sequence or a fragment of this sequence. The present application also relates to a process for producing isochlorogenic acid from chlorogenic acid, which comprises producing said protein and bringing it into contact with chlorogenic acid.

Classes IPC  ?

• C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux
• C12N 9/10 - Transférases (2.)
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• C12N 9/20 - Scission des triglycérides, p.ex. au moyen de lipase

Abrégé

The present application relates to strains of Carnobacterium maltaromaticum, a bacterial preparation comprising at least one strain of Carnobacterium maltaromaticum, and their use in the preparation of a food product.

Classes IPC  ?

• A23C 9/12 - Préparations à base de lait fermenté; Traitements utilisant des micro-organismes ou des enzymes
• A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques

Abrégé

The present invention relates to methods and compositions for the diagnostic and for the treatment of nasal intestinal type adenocarcinomas (ITAC). The inventors used a non-invasive brushing technique, which permits to identify transcriptomic and methylation modifications that are consistent with phenotypic profiles and ITACs natural history. Thus, they identified CACNA1C as a new predictive marker of ITAC. In particular, the invention relates to a method of determining whether a subject has or is at risk of having nasal intestinal type adenocarcinoma (ITAC) comprising determining the expression level of CACNA1C in a sample wherein said expression level indicates whether the subject has or is at risk of having a nasal intestinal type adenocarcinoma (ITAC).

Classes IPC  ?

• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a method and a system for a training program for a subject receiving medical attention, where the training program comprises at least one succession of steps associated to objectives to be achieved to reach a target objective.

Classes IPC  ?

• G09B 19/00 - Enseignement non couvert par d'autres groupes principaux de la présente sous-classe
• G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives

Abrégé

The invention relates to a process for producing a sunflower protein isolate, said process comprising the following steps: (a) providing a sunflower seed press cake, preferably a sunflower seed cold press cake; (b) mixing said sunflower seed press cake with an aqueous NaCI solution at a pH ranging from 3 to 4.5, in order to solubilize proteins present in said sunflower seed press cake and to thus obtain a solubilised protein solution, wherein said aqueous NaCI solution has a NaCI concentration ranging from 0.2 to 0.6 mol.L-1; (c) separating said solubilised protein solution from solids therein; (d) subjecting said solubilised protein solution obtained in step c) to one or several membrane filtration(s) to obtain a protein isolate, and optionally drying said protein isolate to obtain a dry sunflower protein isolate. The invention also relates to a sunflower protein isolate and its use and product which incorporate.

Classes IPC  ?

• A23J 1/14 - Préparation des compositions à base de protéines pour l'alimentation; Ouverture des œufs par grandes quantités et séparation du jaune du blanc à partir des tourteaux ou des graines oléagineuses
• A23L 11/30 - Légumes secs, c. à d. fruits de plantes légumineuses, pour l'obtention d'aliments; Produits dérivés de légumineuses; Leur préparation ou leur traitement Élimination des substances indésirables, p.ex. des substances amères
• A23J 3/14 - Protéines végétales
• A23L 2/66 - Protéines
• B01D 61/14 - Ultrafiltration; Microfiltration

Abrégé

The invention relates to a method for concealing data in an image or a video stream inside a compression chain, said method being implemented by a computer and comprising the following steps: - a structuring and processing phase, during which at least one image is structured into blocks comprising coefficients; - a phase of converting and quantifying blocks so as to generate converted and quantified coefficients; - entropic coding intended to code the converted and quantified coefficients. The method according to the invention further comprises a step of concealing data, during which bits of said data are concealed by modifying converted and quantified coefficients located in a high frequency zone of at least some of said blocks that relate to the luminance component of the video stream and that are intra-coded. This modification is performed after the quantification but before the entropic coding.

Classes IPC  ?

• H04N 19/467 - Inclusion d’information supplémentaire dans le signal vidéo pendant le processus de compression caractérisée par le caractère invisible de l’information incluse, p.ex. un filigrane
• H04N 19/11 - Sélection du mode de codage ou du mode de prédiction parmi plusieurs modes de codage prédictif spatial
• H04N 19/132 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’élément, le paramètre ou la sélection affectés ou contrôlés par le codage adaptatif Échantillonnage, masquage ou troncature d’unités de codage, p.ex. ré-échantillonnage adaptatif, saut de trames, interpolation de trames ou masquage de coefficients haute fréquence de transformée
• H04N 19/159 - Type de prédiction, p.ex. prédiction intra-trame, inter-trame ou de trame bidirectionnelle
• H04N 19/18 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c. à d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant un ensemble de coefficients de transformée
• H04N 19/48 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant des techniques de traitement dans le domaine compressé autres que le décodage, p.ex. modification de coefficients de transformées, de données de codage à longueur variable ou de données de codage par longueur de plage
• G06T 1/00 - Traitement de données d'image, d'application générale

Abrégé

The invention relates to a fluidic system for loading a therapeutic or imaging agent into the lumen of extracellular vesicles (EV) from producer cells, comprising at least one container, a liquid medium contained in the container, producer cells, a liquid medium stirrer and means for controlling the speed of the stirrer suitable for the growth of the producer cells, characterized in that it also comprises means for controlling the speed of the stirrer and the stirrer, of which the shape and dimensions of the container are suitable for generating a turbulent flow of the liquid medium in the container for exerting shear stresses on the producer cells in order to carry out the loading of a therapeutic or imaging agent into the lumen of the extracellular vesicles (EV) produced simultaneously by the fluidic system.

Classes IPC  ?

• C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p.ex. avec agitateur à turbine
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

A process for preparing a sunflower seed protein isolate and a protein isolate which is obtainable by such process. The process comprises the following steps: mixing a defatted seed meal with an aqueous NaCl solution at a basic pH; separating said solubilised protein solution from solids; diafiltering said solubilised protein solution through an ultrafiltration membrane system using an aqueous NaCl diafiltration NaCl solution and at least 2 diavolumes of said aqueous NaCl diafiltration solution, diafiltering said NaCl-diafiltered protein; concentrating said purified protein solution; and drying said purified protein concentrate to obtain a protein isolate.

Classes IPC  ?

• A23J 1/14 - Préparation des compositions à base de protéines pour l'alimentation; Ouverture des œufs par grandes quantités et séparation du jaune du blanc à partir des tourteaux ou des graines oléagineuses
• A23L 11/30 - Légumes secs, c. à d. fruits de plantes légumineuses, pour l'obtention d'aliments; Produits dérivés de légumineuses; Leur préparation ou leur traitement Élimination des substances indésirables, p.ex. des substances amères
• A23J 3/14 - Protéines végétales
• B01D 61/14 - Ultrafiltration; Microfiltration
• B01D 61/16 - Prétraitement du courant d'alimentation
• C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux
• A23L 2/66 - Protéines

Abrégé

The present invention relates to the field of crop fertilization and particularly to a biofertilizing bacterial strain. The present invention relates in particular to the bacterial strain deposited on 24 October 2018 at the Collection Nationale de Culture de Micro-organismes (CNCM), 28 rue du Dr. Roux, 75724 PARIS CEDEX 15, by virtue of the Treaty of Budapest, under number CNCM I-5372, as well as to uses of said strain. The invention also relates to a composition comprising the bacterial strain mentioned above and to a fertilization method comprising the application of this composition to a plant or to a soil.

Classes IPC  ?

• C12N 1/20 - Bactéries; Leurs milieux de culture
• A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir d
• C05F 11/08 - Engrais organiques comportant l'addition de cultures bactériennes, de mycélium ou similaires

Abrégé

The invention relates to the non-therapeutic use, as a DNA-demethylating agent, of at least one organometallic compound comprising an iron atom bound to two terpyridine groups. The invention also relates to an organometallic compound comprising an iron atom bound to two terpyridine groups, to be used as a drug.

Classes IPC  ?

• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61K 8/19 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés inorganiques
• A61K 31/295 - Composés de métaux du groupe du fer
• A61P 35/00 - Agents anticancéreux
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
• A61Q 19/00 - Préparations pour les soins de la peau
• A61Q 19/06 - Préparations pour lutter contre la cellulite

Abrégé

The invention relates to a bacteria of the Streptococcus thermophilus species with reference CNRZ160 for use in the prevention and/or treatment of intestinal inflammation in an individual.

Classes IPC  ?

• A61K 35/744 - Bactéries lactiques, p.ex. entérocoques, pédiocoques, lactocoques, streptocoques ou leuconostoques
• A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 1/12 - Antidiarrhéiques
• A61P 37/06 - Immunosuppresseurs, p.ex. médicaments pour le traitement du rejet de greffe

Abrégé

A process for producing a protein isolate from an oilseed meal, and the isolate thus obtained, said isolate comprising proteins and an amount of 4 wt. % or less of phytic acid, said amount of phytic acid being by weight of proteins in said isolate. The process may comprise the following steps: a) providing an oilseed meal; b) mixing the oilseed meal with a first aqueous solvent to form a slurry at a pH ranging from 6 to 7.8, said slurry having a solid phase; c) separating said solid phase from said slurry, d) mixing said separated solid phase with a second aqueous solvent at a pH ranging from 1 to 3.5, preferably from 2 to 3, to form a mixture said mixture having a liquid phase; e) separating said liquid phase from said mixture formed in step d); f) f1) mixing the separated liquid phase to a phytase at a temperature and a pH suitable for phytase activity to obtain a mixture having a liquid phase and a solid phase; and/or f2) mixing the separated liquid to a salt, to obtain a resulting liquid composition having a molar concentration of said salt ranging from 0.05M to 0,5M, at a temperature ranging from 40°C to 70°C, to obtain a mixture having a liquid phase and a solid phase; g) precipitating a solid phase from the liquid of step f) for example by a cooling down step of the mixture to a temperature of 30°C or less; h) separating said solid precipitate from the liquid of step g) said liquid comprising a water-rich liquid phase and an oil-rich liquid phase; i) separating said water-rich liquid phase from said oil-rich liquid phase, j) subjecting said water-rich liquid phase obtained in step i) to one or several membrane filtration(s) to obtain a protein isolate; and k) optionally, drying said protein isolate to obtain a dry protein isolate.

Classes IPC  ?

• A23J 1/00 - Préparation des compositions à base de protéines pour l'alimentation; Ouverture des œufs par grandes quantités et séparation du jaune du blanc
• A23L 5/20 - Préparation ou traitement des aliments ou produits alimentaires en général; Aliments ou produits alimentaires ainsi obtenus; Leurs matériaux Élimination de constituants indésirables, p.ex. désodorisation ou détoxication
• A23L 11/30 - Légumes secs, c. à d. fruits de plantes légumineuses, pour l'obtention d'aliments; Produits dérivés de légumineuses; Leur préparation ou leur traitement Élimination des substances indésirables, p.ex. des substances amères
• A23J 1/14 - Préparation des compositions à base de protéines pour l'alimentation; Ouverture des œufs par grandes quantités et séparation du jaune du blanc à partir des tourteaux ou des graines oléagineuses
• A23J 3/14 - Protéines végétales
• A23J 3/16 - Protéines végétales à partir de soja
• C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux

Abrégé

The invention relates to a compound of formula (I) and to the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compound of formula (I) in the treatment of cancer, particularly by photodynamic therapy.

Classes IPC  ?

• C07D 475/04 - Composés hétérocycliques contenant des systèmes cycliques ptéridine avec un atome d'oxygène lié directement en position 4 avec un atome d'azote lié directement en position 2
• A61K 31/409 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil ayant quatre de ces cycles, p.ex. dérivés de la porphine, bilirubine, biliverdine
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

The invention relates to human mesenchymal stem cells obtained from Wharton's jelly, a process for the preparation thereof, and the therapeutic uses thereof, in particular for the treatment of sepsis.

Classes IPC  ?

• A61K 35/28 - Moelle osseuse; Cellules souches hématopoïétiques; Cellules souches mésenchymateuses de toutes origines, p.ex. cellules souches dérivées de tissu adipeux
• C12N 5/0775 - Cellules souches mésenchymateuses; Cellules souches dérivées du tissu adipeux
• A61K 35/51 - Cordon ombilical; Sang de cordon ombilical; Cellules souches ombilicales
• A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques

Abrégé

The present invention relates to an enzymatic method for removing sulphite. In particular, the present invention relates to a method for converting sulphite present in a composition into thiosulphate, comprising the introduction of 3-mercaptopyruvate sulphurtransferase (3-MST) and a substrate of said 3-mercaptopyruvate sulphurtransferase into said composition. The present invention can be used in particular in the pharmaceutical, cosmetic, food and chemical fields, and any field involving the use of sulphite.

Classes IPC  ?

• C12G 1/04 - Sulfitage du moût; Désulfitage
• C12H 1/00 - Pasteurisation, stérilisation, conservation, purification, clarification ou vieillissement des boissons alcoolisées

Abrégé

The invention relates to a process for extracting tantalum from an acid aqueous phase A1 comprising at least one step comprising the bringing of the aqueous phase A1 into contact with a phase A2 that is not miscible with water, then the separation of the aqueous phase A1 from the phase A2, the phase A2 being formed by an ionic liquid or a mixture of ionic liquids as extractant. The invention also relates to a process for recovering tantalum using this extraction process and also to a use of an ionic liquid or of a mixture of ionic liquids as extractant, for extracting the tantalum from such an aqueous phase A1.

Classes IPC  ?

• C22B 3/26 - Traitement ou purification de solutions, p.ex. de solutions obtenues par lixiviation par extraction liquide-liquide utilisant des composés organiques
• C22B 34/24 - Obtention du niobium ou du tantale

Abrégé

The invention relates to a method for identifying an isthmus in a three-dimensional map of a cardiac cavity by means of a processing unit configured to perform the following steps: a) correlation between a set of stimulated points of the cardiac cavity, each stimulated point being represented by a set of signals that are obtained following surface electrocardiography (ECG), excluding ventricular tachycardia, b) identification of a watershed line on the basis of the above correlation results and of the 3D coordinates of the stimulated points in the 3D map, c) determination of the isthmus based on a 3D corridor substantially transverse to the watershed line.

Classes IPC  ?

• A61B 5/349 - Détection de paramètres spécifiques du cycle de l'électrocardiogramme
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
• A61B 5/35 - Détection de paramètres spécifiques du cycle de l'électrocardiogramme par comparaison à des gabarits
• A61B 5/366 - Détection de complexes QRS anormaux, p.ex. élargissement

Abrégé

A piezoelectric sensor includes: a body (10) with a central cavity (12); and a membrane (11) extending over the cavity (12), which membrane is fastened to the body (10) via its periphery and includes a carrier layer (111) made of polymer and a sensitive layer (113) made of piezoelectric polymer, the membrane (11) being able to deform or vibrate. The sensitive layer (113) is made of a material comprising a polymer filled with inorganic nanomaterials. Instrument including such a sensor.

Classes IPC  ?

• G01H 11/08 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores par détection des changements dans les propriétés électriques ou magnétiques par des moyens électriques utilisant des dispositifs piézo-électriques
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p.ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

The invention relates to a method for discrimination and identification of an object in a complex scene by 3-D imaging. The method comprises the following steps: - generating a sequence of 2-D MIP images of the object from a 3-D voxel volume of the complex scene, said volume being visualized by an operator using an iterative MIP type process, from a projection plane and from an intensity threshold determined by the operator at each iteration, - automatically extracting, from the sequence of images, the coordinates of a reduced volume corresponding to the sequence of images, - selecting one of the intensity thresholds utilized during the iterations, - automatically extracting coordinates from the 3-D volume of the complex scene, and a reduced 3-D volume containing the object from the selected intensity threshold, - automatically generating an optimized intensity threshold and an optimized voxel volume from the reduced volume, by optimization of the intensity threshold, a colour being associated with each intensity, - identifying the object by visualization.

Classes IPC  ?

• G06T 15/08 - Rendu de volume
• G06T 7/11 - Découpage basé sur les zones
• G06T 7/136 - Découpage; Détection de bords impliquant un seuillage

Abrégé

The invention relates to a heat insulation material produced by drying a fibrous matrix impregnated with a solution of pseudo-peptides of formula (I), wherein: R is a side-chain of a natural or synthetic amino acid, R1 is either a linear or branched (C1-C8)alkyl group, or a linear or branched (C1-C8)alcoxy group, or an aryl group, or an aryl(C1-C4)alkyl group, or an aryloxy group, or a saturated or unsaturated heterocycle, n = 1 or 2, and A is an aromatic or heteroaromatic group with at least one cycle.

Classes IPC  ?

• B27K 3/34 - Agents d'imprégnation organiques
• D06M 13/342 - Acides aminocarboxyliques; Bêtaïnes; Acides aminosulfoniques; Sulfobêtaïnes
• D06M 13/35 - Composés hétérocycliques
• D06M 13/422 - Hydrazides
• E04B 1/76 - Isolation thermique ou acoustique, absorption ou réflexion de la chaleur ou du son; Autres méthodes de construction procurant des conditions thermiques ou acoustiques favorables, p.ex. par accumulation de chaleur à l'intérieur des murs spécifiquement relatives à la chaleur uniquement

Abrégé

The invention relates to a method and a circuit for detecting an electric arc in an electric circuit supplied with AC current during a supply period, which comprises measuring at least one input signal (S) among a current (I) and an input voltage (U) of the electric circuit, characterised by supplying a warning signal (Al) to indicate that an electric arc occurs when the input signal (S) is constant over at least one portion of the supply period, digitally sampling the input signal (S) during the measurement thereof according to predetermined levels and, in order to identify that the input signal (S) is constant, determining the frequency at which each level is reached by the input signal (S) over a predetermined time window, comparing the frequency of each level with a predetermined warning threshold, and issuing the warning signal if the frequency of at least one of the levels is higher than the warning threshold. The invention also relates to a switching device including such a circuit.

Classes IPC  ?

• H02H 1/00 - CIRCUITS DE PROTECTION DE SÉCURITÉ - Détails de circuits de protection de sécurité

Abrégé

The present invention relates to a method for diagnosing a cardiovascular event or disease in a subject by measuring sTREM-1 level in a sample.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention concerns a liquid (meth)acrylic syrup for impregnating a fibrous substrate. The invention concerns in particular a viscous liquid syrup primarily containing methacrylic or acrylic components. The invention also concerns a method of producing this syrup. The invention further concerns a method of impregnating a fibrous substrate or long fibres with the viscous liquid syrup. The invention also concerns a fibrous substrate pre-impregnated with the syrup which can be used for manufacturing mechanical or structured products or parts. The invention further concerns a method of manufacturing mechanical or structured parts or articles and three-dimensional mechanical or structured parts obtained by this method. The invention is used for producing mechanical parts or structural elements made of fireproof thermoplastic composite material.

Classes IPC  ?

• C08L 33/12 - Homopolymères ou copolymères du méthacrylate de méthyle
• C08J 5/10 - Renforcement des composés macromoléculaires avec des matériaux fibreux en vrac ou en nappes caractérisé par les additifs utilisés dans le mélange de polymères
• C08K 3/22 - Oxydes; Hydroxydes de métaux
• C08K 5/5313 - Composés phosphiniques, p.ex. R2=P(:O)OR'
• C08K 7/02 - Fibres ou "whiskers"
• D06M 13/285 - Phosphines; Oxydes de phosphine; Sulfures de phosphine; Acides phosphiniques ou phosphineux ou leurs dérivés
• D06M 15/263 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone d'acides carboxyliques non saturés; Leurs sels ou esters

Abrégé

A composition for manufacturing an elastic tannin based foam material comprises tannins according to an amount generally comprised between 10% and 80% by weight, and an isocyanate in an amount comprised between 5% and 80% by weight. The composition further comprises a substance having an aminic functionality and a alkoxylated functionality, which substance includes at least one amino group and at least one alkoxylated group, these groups being part of the same molecule.

Classes IPC  ?

• C08G 18/50 - Polyéthers contenant des hétéro-atomes autres que l'oxygène
• C08G 18/32 - Composés polyhydroxylés; Polyamines; Hydroxyamines
• C08G 18/48 - Polyéthers

Abrégé

The present invention relates to a cooking device (1) including a metal holder (2) supporting a ceramic cooking surface (3), the holder (2) having a hardness no lower than 150 HV. According to the invention, the holder (2) forms a substrate supporting a surface layer made of a transition metal boride or boronitride forming the cooking surface (3). The present invention further relates to a culinary article comprising a cooking device of the type above-mentioned, a household cooking appliance comprising a cooking device of the type above-mentioned, as well as a method for producing a cooking device of the type above-mentioned.

Classes IPC  ?

• A47J 36/02 - Emploi de matériaux spécifiés, p.ex. double-fonds avec une plaque de cuivre ou une plaque isolante

Abrégé

The present invention relates to a peptide comprising at least 6 consecutive amino acid selected from the amino acid sequence SEQ ID NO: 2 and a function-conservative variant. The invention also relates to a peptide comprising at least 6 consecutive amino acid selected from the amino acid sequence SEQ ID NO: 1 or SEQ ID NO: 2 and a function-conservative variant for use in the treatment of a cardiovascular disease.

Classes IPC  ?

• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

The invention relates to a method of controlling a permanent-magnet synchronous machine (3) comprising a stator and a rotor. The method comprises a step of determining an estimated position ($) of the rotor, a step of determining a second direct voltage setpoint (?d2*) which is alternately equal to a first direct voltage setpoint (?d1*) or equal to the first direct voltage setpoint (?d1*) plus a predetermined periodic signal (G). The step of determining an estimated position ($) of the rotor comprises a step of determining a coupling term (???), a step of determining a speed of rotation of the rotor (O5) as a function of said coupling term (???), and a step of determining the estimated position ($) of the rotor by integrating the speed of rotation of the rotor (O5).

Classes IPC  ?

• H02P 6/18 - Dispositions de circuits pour détecter la position sans éléments séparés pour détecter la position
• H02P 21/18 - Estimation de la position ou de la vitesse

Abrégé

The invention relates to a food cooking surface for a cookware item or an electrical household cooking appliance, consisting of a deposit of nitride of metal elements on a substrate, the metal elements of the deposit comprising one or more X transition metals and aluminium. The production of the deposit comprises a nitridation step in order to obtain a coating of type (X,Al)N. According to the invention, the (X,Al)N-type coating is a coating of nitride(s) of the one or more X transition metals, enriched with aluminium, in which niobium and/or zirconium is/are make up the most part of the X transition metal(s), the atomic ratio of aluminium in the metal elements of the deposit being at least equal to 20%. The invention also relates to cookware items and electrical household appliances intended for the cooking of food, comprising the above-mentioned type of cooking surface.

Classes IPC  ?

• C23C 14/06 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le matériau de revêtement
• A47J 36/02 - Emploi de matériaux spécifiés, p.ex. double-fonds avec une plaque de cuivre ou une plaque isolante
• C23C 14/00 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement
• C23C 14/02 - Pré-traitement du matériau à revêtir

Abrégé

Method of stabilizing a DC electric network, this network comprising a DC voltage source (11) powering electric loads (12,18, 24) which are connected in parallel across the terminals of the voltage source (11) and which are each intended to receive a setpoint of the current or the power, characterized in that the network is stabilized by regulating the setpoints applied to the loads (12,18, 24) by means of a virtual stabilization impedance generated across the terminals of each load (12,18, 24), these virtual impedances being dimensioned so as to stabilize the network in various desired operating points and in various given configurations of the network comprising the state where at least one load is inactive or faulty and the state where the stabilization of a load is inactive, each virtual impedance being generated by means of a nonlinear regulating loop acting on the setpoint of the corresponding load.

Classes IPC  ?

• H02J 3/16 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par réglage de puissance réactive
• H02J 1/14 - Circuits pour réseaux principaux ou de distribution, à courant continu Équilibrage de la charge dans un réseau
• H02J 3/24 - Dispositions pour empêcher ou réduire les oscillations de puissance dans les réseaux

Abrégé

The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis.

Classes IPC  ?

• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire

Abrégé

The present invention relates to a food-cooking surface (8) for a culinary article or domestic electrical cooking appliance, consisting in depositing Zr and/or Nb and/or Ti on a substrate (4), the production process including a step of carburizing and/or nitriding at least one of the elements, characterized in that the cooking surface (8) also includes depositing Si so as to produce (Zr/Nb/Ti)-Si-(N/C) coatings (6). The present invention also relates to a culinary article or a domestic electrical cooking appliance comprising such a cooking surface (8).

Classes IPC  ?

• C23C 14/06 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le matériau de revêtement
• A47J 27/00 - Récipients de cuisson

Abrégé

The invention relates to pharmaceutical compositions and food products containing peptides derived from the as1-casein in milk and having benzodiazepine-type activity and particularly, anxiolytic activity.

Classes IPC  ?

• A61K 38/01 - Protéines hydrolysées; Leurs dérivés 
• A01K 67/00 - NÉCESSITÉS COURANTES DE LA VIE ÉLEVAGE; CHASSE; PIÉGEAGE; PÊCHE ÉLEVAGE; AVICULTURE; APICULTURE; PISCICULTURE; PÊCHE; OBTENTION D'ANIMAUX, NON PRÉVUE AILLEURS; NOUVELLES RACES D'ANIMAUX Élevage ou obtention d'animaux, non prévus ailleurs; Nouvelles races d'animaux
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 25/08 - Antiépileptiques; Anticonvulsivants
• A61P 25/20 - Hypnotiques; Sédatifs
• A61P 25/22 - Anxiolytiques
• C12N 15/00 - Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p.ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
• C12N 15/12 - Gènes codant pour des protéines animales

Abrégé

The invention relates to peptides and, in particular, heptapeptides derived from milk casein as1 and having anxiolytic activity. The invention also relates to pharmaceutical and food compositions containing said peptides and to the preparation methods thereof.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A23L 33/19 - Protéines du lait
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 25/22 - Anxiolytiques
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/12 - Gènes codant pour des protéines animales
• C12P 21/06 - Préparation de peptides ou de protéines préparés par hydrolyse d'une liaison peptidique, p.ex. hydrolysats

Abrégé

A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterised by the ability to treat, ameliorate, or lessen the symptoms of sepsis, septic shock or sepsis-like conditions.

Classes IPC  ?

• C12N 15/12 - Gènes codant pour des protéines animales
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 31/04 - Agents antibactériens
• A61P 37/02 - Immunomodulateurs
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus