A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.
A method for minimizing the dead volume (Vd) in a vial (10) presenting a liquid (L) for aspiration is provided. The method comprises, after determining that the liquid volume (Vi) indicated to be available in the vial (10) is not sufficient for a further aspiration step, moving downward in direction towards the bottom of the vial (10) by means of a pipetting arm (20) presenting a pipetting tip (21) and along the z-axis of the pipetting arm (20) until the pipetting arm (20) comes to a stop in a first stop position (S1z). Then, the actual available liquid volume (Va) is calculated based i.a. on said first stop position (S1z). In case the calculated actual available liquid volume (Va) is sufficient, a further aspiration step can be executed. Furthermore, a liquid handling system for minimizing dead volume (Vd), a computer-implemented method for controlling a pipetting arm (20) of such a liquid handling system, and the use of a hysteresis determination method for minimizing dead volume (Vd) are provided.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A method is described of operating a pipetting system (10) that has a worktable (12), at least one manipulator arm (18), and first and second Z-rods (20′,20″) arranged on the at least one manipulator arm (18). The method involves receiving by the second Z-rod (20″) a tool (24) via an adapter attached to the second Z-rod (20″), wherein the tool (24) has a central axis and a working area, the working area being defined by a circle which center is located on the central axis of the tool (24) and which radius being a distance between the central axis and a largest extension of an outline of the tool (24) in a projection.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A method for aspirating a first liquid medium from a sample container with a laboratory automation device, wherein the first liquid medium is above a second liquid medium, which has a higher density and/or viscosity as the first liquid medium comprises: detecting a surface position of a surface of the first liquid medium; calculating an estimated interface position of an interface between the first liquid medium and the second liquid medium from the surface position and calculating a safety position between the surface position and the estimated interface position by adding a safety offset to the estimated interface position; and lowering a pipette of the laboratory automation device into the sample container and aspirating the first liquid medium from the sample container with the pipette by generating an underpressure in the pipette until a pipette tip of the pipette reaches the safety position.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
6.
LOG FILE EVALUATION OF LABORATORY AUTOMATION DEVICE WITH STATE MACHINES
A method for determining states of a laboratory automation device includes: receiving a log file from the laboratory automation device, the log file including entries of events that occurred during a procedure performed by the laboratory automation device, wherein the events have been created by components of the laboratory automation device and each entry includes at least an event time and an event type; providing a state machine of the laboratory automation device, the state machine encoding states of the laboratory automation device and transitions between the states, wherein each transition is starting at a state and points to another state and wherein each transition is associated with an entry scheme in the log file, the entry scheme including at least an event type; setting a current state of the laboratory automation device to a beginning state; moving through the entries of the log file along increasing event time and associating the entries with the current state; during the moving, when an entry scheme associated with a transition starting at the current state is identified in the log file, changing the current state to the state to which the transition (60) is pointing.
A method for generating a control program for a laboratory automation device includes receiving configuration data of the laboratory automation device, generating a three-dimensional model of the components of the laboratory automation device from the configuration data, the three-dimensional model additionally including a virtual pipette; displaying the three-dimensional model with a virtual reality headset; receiving movement data of a motion sensing controller controlled by a user wearing the virtual reality headset, the movement data indicating a three-dimensional movement of the motion sensing controller in space; determining a movement of the virtual pipette in the three-dimensional model from the movement data and updating the three-dimensional model according to the movement of the virtual pipette; and generating a control program for the laboratory automation device from the movement data.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A pipette tip extension attachable to a pipette tip with the pipette tip extension having a proximal end, a distal end, and exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall having an outer side and inner side and forming at the proximal end a reception aperture for inserting a pipette tip, and at a distal end a dispense aperture. An inner cavity is enclosed by the inner side of the exterior wall and one or more distance elements connected to the inner side of the exterior wall. The distance element(s) being configured to position a pipette tip within the inner cavity and to establish fluid uptake area adjacent the inner side of the exterior wall with the fluid uptake area extending from the dispense aperture towards the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture.
A rotary valve comprises a stator member with a stator face, the stator member having at least two stator channels for conducting a fluid and opening into the stator face; a rotor member with a rotor face facing and in contact with the stator face, the rotor member having a rotor channel in the rotor face, wherein the rotor member is rotatable with respect to the stator member about a rotation axis, such that in a conducting position, the rotor channel interconnects the at least two stator channels to be in fluid communication; and a rotary encoder assembly adapted for determining a rotary position of the rotor member, the rotary encoder assembly comprising an encoder member and an encoder module, which is adapted to sense a rotary position of the encoder member. The encoder member is rigidly connected to the rotor member and surrounds the rotor member.
F16K 37/00 - Moyens particuliers portés par ou sur les soupapes ou autres dispositifs d'obturation pour repérer ou enregistrer leur fonctionnement ou pour permettre de donner l'alarme
F16K 31/04 - Moyens de fonctionnement; Dispositifs de retour à la position de repos magnétiques utilisant un moteur
F16K 11/08 - Soupapes ou clapets à voies multiples, p.ex. clapets mélangeurs; Raccords de tuyauteries comportant de tels clapets ou soupapes; Aménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont toutes les faces d'obturation se déplacent comme un tout comportant uniquement des robinets à boisseau
A robotic sample handling system (100) may be provided for performing sample handling tasks in a laboratory environment. The system may comprise at least one robotic arm (140), (142) which is controllable to be positioned in a plane parallel to a work area and along a Z-axis perpendicular to the work area, and a controller (180) configured to control the robotic arm to position and operate the robotic arm as part of a sample handling task. The work area may comprise a module (204) for use with one or more of the samples, wherein the module comprises a mechanism which is actuatable by downward force, and wherein the controller is configured to control the robotic arm to actuate the mechanism by pushing downward in Z-direction. For example, the module may be a stand (204) for a sample container which comprise a push-push mechanism which may be operated by the robotic arm to bring the sample in the sample container in a vicinity of an effector, such as a magnet or a heat source.
A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.
The invention relates to a multi-channel head (100) of a liquid handling apparatus for aspirating and dispensing a metered amount of liquid, comprising:
an array of connectors (130) for picking up an array of disposable tips, whereby a peripheral end of each connector is provided with an elastomeric seal (140);
an alignment plate (150) that is moveable in a z-direction and has a plurality of openings through which the connectors (130) extend,
a linear displacement mechanism (170b, 175), driven by a motor (180), for moving the alignment plate (150) in z-direction relative to the connectors, and a controller for controlling the motor.
The multi-channel head is configured to attach the array of disposable tips in a pick-up action, in which the multi-channel head (100) is lowered relative to the disposable tips so as to insert each connector into an internal passageway of a corresponding disposable tip by an amount sufficient to bring an upper collar of the disposable tips into contact with an underside (150s) of the alignment plate. This insertion deforms the elastomeric seal against the tip internal passageway so as to form a sealing contact therewith. The controller of the multi-channel head (100) is programmed such that once the pick-up action is complete, an alignment action is performed in which the alignment plate (150) is moved relative to connectors (130) by an amount sufficient to close any gap between the underside (150s) of the alignment plate and the upper surface of the tip collars that arises due to e.g. relaxation of the deformed seals (140).
A laboratory automation device comprises a workspace with liquid containers and a pipetting arm for moving liquids between the liquid containers; a housing enclosing the workspace; a door of the housing for accessing the workspace, wherein the door comprises a transparent display for displaying information and for allowing a person to view into the workspace and a tracking sensor for tracking an eye position of the person. The laboratory automation device is adapted for determining the eye position of the person from sensor data acquired with the tracking sensor; and for displaying information for a notification area in the workspace on the transparent display, such that the information is displayed from a perspective of the person in front of the notification area.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
A method of measuring the alignment of one or more pipetting tips in an automated pipetting system where the one or more pipetting tips are mounted on one or more adapters of a pipetting head approximately perpendicular to the pipetting head mounting surface is disclosed. The orifices at the end of the one or more pipetting tips are mapped with an image capture device having a sensor placed in face and distant of the orifices. The method sends the acquired data from mapping the orifices of the one or more pipetting tips to the data processor, generating an image of the orifices of the one or more pipetting tips, determining the center positions of orifices, and delivering alignment information for the one or more pipetting tips.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
16.
METHOD AND DEVICE FOR DETECTING CONTACT OF A PIPETTE TIP WITH A LIQUID AS WELL AS A LABORATORY SYSTEM WITH SUCH A DEVICE
A method for detecting contact of a pipette tip with a surface of a liquid in a pipetting device is disclosed. The method consists of moving the pipette tip in the direction of the surface of the liquid thereby measuring an absolute capacitance between the pipette tip and a reference potential and generating a sampled output signal. A predicted momentary sample value of the output signal is generated based on a plurality of past sample values of the output signal. A contact signal indicative of the pipette tip being in contact with the surface of the liquid is generated based on comparing a momentary sample value of the output signal with the predicted momentary sample value of the output signal. A corresponding pipetting device capable of performing the method as a laboratory system, in particular an automated liquid processing system, with one or more such pipetting devices are proposed.
Some embodiments are directed to a method for tracking lysis progress in an automated lysing device. For example, the lysing device may be configured to execute multiple iterations of lysing at a defined location on the tissue section and imaging the defined location on the tissue section using a camera. From the images a lysing parameter may be determined to improve lysing.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
18.
IMAGE REGISTRATION WITH APPLICATION IN TISSUE TREATMENT
Some embodiments are directed to image registration. A rotation angle is determined and subsequently a translation vector. The rotation angle and translation vector together defining an alignment transformation between a first image and a second image. Determining the rotation angle may include iterating over multiple potential rotation angles, and determining alignment.
G06T 3/00 - Transformation géométrique de l'image dans le plan de l'image
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c. à d. recalage des images utilisant des procédés basés sur les caractéristiques
An incubation cassette for reducing liquid evaporation from wells of a microplate with a frame for receiving a microplate with wells, the frame having a central first opening surrounded by an inner wall, the dimensions are designed for inserting a microplate, and the frame having an outer wall that runs essentially parallel to the inner wall and which is attached to the inner wall connects so that a liquid reservoir surrounding the first central opening for receiving a liquid is formed by the two walls and the intermediate base is disclosed. The incubation cassette also includes a float provided in the liquid reservoir that can be brought into fluid contact with the liquid held in the liquid reservoir in such a way that the float is in relation to the liquid level of the liquid in the liquid reservoir absorbed liquid experiences buoyancy.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
G01F 23/68 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme par des flotteurs du type à flotteur libre en utilisant des moyens d'indication actionnés électriquement
A pipette includes an end section, a first section, a second section and a third section aligned along a central axis of the pipette tip. The end section comprises an orifice for aspirating and dispensing a fluid. A first kink is formed in an inner surface of the pipette tip between the first section and the second section, such that an angle between the inner surface of the first section and the central axis is smaller than an angle between the inner surface of the second section and the central axis. A second kink is formed in the inner surface of the pipette tip between the second section and the third section, such that the angle between the inner surface of the second section and the central axis is smaller than an angle between the inner surface of the third section and the central axis.
A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.
A cover for a fluid container having an essentially plane cover plate for closing at least one opening of at least one fluid container and at least two ports, and each port has a through channel extending through the entire thickness of the cover plate and a fluid impermeable first membrane is arranged over the entire cross section of the through channel of the first port and an at least gas permeable second membrane is arranged over the entire cross section of the through channel of the second port is disclosed.
A rotary valve includes a stator member with a planar stator face, the stator member having a plurality of stator channels for conducting a fluid; and a rotor member with a planar rotor face facing and in contact with the stator face, the rotor member having a rotor channel; wherein the rotor member is rotatable with respect to the stator member about a rotation axis, such that in a conducting position, the rotor channel interconnects two of the stator channels and the two stator channels are in fluid communication; wherein at least one of the stator channels has a transverse channel section opening into the stator face and running transversely with respect to the rotation axis; wherein the rotor channel has a bottom, which at an intersection end of the rotor channel is inclined with respect to the rotation axis, such that the rotor channel elongates an inner surface of the stator channel, when the rotor member is in the conducting position.
F16K 11/074 - Soupapes ou clapets à voies multiples, p.ex. clapets mélangeurs; Raccords de tuyauteries comportant de tels clapets ou soupapes; Aménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont toutes les faces d'obturation se déplacent comme un tout comportant uniquement des tiroirs à éléments de fermeture articulés à pivot à faces d'obturation planes
A method is disclosed for controlling at least one of aspirating and of dispensing a liquid dose or of producing a liquid dose in a pipette or in receptacle, the method having the steps of first loading a first pipette with a first working medium at a first pressure having a first sign with respect to a reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the first pipette, second loading a second pipette with a second working medium at a second pressure having a second sign with respect to the reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the second pipette, discharging a pressure in the first working medium through a controlled valve arrangement to the reference pressure between first and second loadings. A pipetting device is also disclosed.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
25.
DISPLACEMENT DEVICE AND METHOD FOR DISPLACING FLUID VOLUMES
A displacement device for displacing a displacement volume is disclosed. The device has a first fluid space and a second fluid space. A first piston is arranged in a movable manner within the first fluid space. The first fluid space is connectable to a pipetting device. The first piston is actuatable by an actuation volume of air or of liquid provided by the pipetting device. A second piston is arranged in a movable manner within the second fluid space. The second piston is constructed to displace a displacement volume of a fluid located within the second fluid space when the second piston is actuated. The second piston is actuated in dependence on the first piston that is actuated by the actuation volume. The actuation volume is different from the displacement volume, and a pipetting system has a displacement device and a method of displacing a displacement volume.
A door for a laboratory workstation is disclosed. The laboratory workstation has a horizontally extending work surface for providing a working area. The door is movable in relation to the work surface in a vertical direction perpendicular to the work surface between a safety position, in which the door closes the working area for manual access of a user, an access position in which the working area is open for manual access of a user, and a loading position.
A method for aspirating a first liquid medium of two liquid media of different density from a sample container comprises: lowering a pipette of the laboratory automation device into the sample container until a pipette tip of the pipette has passed a lowering distance from the surface of the first liquid medium in the sample container, wherein the lowering distance is chosen, such that the pipette tip passes at least an aspiration volume in the sample container; aspirating liquid from the sample container during the lowering of the pipette by generating an underpressure in the pipette, wherein the first liquid medium is aspirated, and after the interface and the pipette tip pass each other, the second liquid medium of the two liquid media is aspirated; measuring a pressure in the pipette during the lowering of the pipette and detecting a position of the interface, when a slope of the pressure changes; when the lowering distance has been passed and no interface is detected, aspirating the aspiration volume from the first liquid medium and dispensing the aspiration volume of the first liquid medium into a further sample container.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
28.
Receiving frame for receiving a support plate for pipette tips
A receiving frame for a support plate for pipette tips that is formed from two opposing longitudinal walls and two opposing transverse walls, each has an upper side and a lower side and laterally enclose an interior space is disclosed. The upper sides of the longitudinal walls and transverse walls together form a circumferential support surface on which a support plate for pipette tips can be reversibly placed. The receiving frame has a footprint on the lower side of the longitudinal walls and the transverse walls.
The invention relates to an arrangement of a gripper finger and a clamp for use in an automated parallel gripper comprising first and second gripper fingers that are moveable in a direction of translation (y), whereby the clamp is connected to the gripper finger at an underside thereof, so as to be rotational about a vertical axis of rotation (135). The clamp has a front face with a contact surface for engagement with a lateral edge of an item to be gripped and has a default orientation in which the front face is parallel to a lateral direction (x) that is perpendicular to the direction of translation (y) and to the vertical rotation axis (135). The arrangement is additionally provided with a self-alignment feature which comprises first and second biasing mechanisms arranged at either side of the rotation axis (135) in lateral direction (x). Each biasing mechanism has a first part (151, 152) connected to the finger and a second part (131, 132) connected to the clamp and is configured to exert a centering force that urges the first and second parts of each biasing mechanism into alignment with each other. When the clamp is in the default orientation, each biasing mechanism is preloaded to exert an equal moment load on the clamp in the direction of translation (y).
A robotic arm of an automated pipetting system has a pipetting tip adapter and a slide switch to detect the presence of pipetting tips on the pipetting tip adapter is disclosed. The slide switch has first support member and second support member configured to slide relative to one another between first and second positions along a movement axis, an electrically conducting contact pad arranged on the first support member, an electrically conducting terminal physically attached to second support member in physical contact with the contact pad when support members are in first position, where the terminal is a first resilient wiping member expanding along the movement axis, first wiping member is not in physical contact with the contact pad when support members are in second position, and an electric current can flow between first wiping member and the contact pad when support members are in first position.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
H01H 1/40 - Contact monté de façon que sa surface de contact soit de niveau avec l'isolation contiguë
H01H 3/16 - Organes moteurs, c. à d. pour actionner le mécanisme d'entraînement par une force mécanique extérieure à l'interrupteur adaptés pour être actionnés dans une position limite ou autre position prédéterminée dans le trajet d'un corps, le mouvement relatif de l'interrupteur et du corps ayant principalement un autre but que d'actionner l'interrupteur, p.ex. un interrupteur
A robotic liquid handling system may be provided comprising a robotic arm and a controller configured to control the robotic arm to position and operate the robotic arm in a workspace of the robotic liquid handling system. The controller may be configured to, as part of a liquid handling task, control the robotic arm to open a reagent reservoir, wherein the reagent reservoir has an opening which is sealed by a foil. The controller may be configured to control the robotic arm to open the foil by controlling the robotic arm to, using a cutting tip (260), cut at least two flaps in the foil, and using a blunt protrusion, push the at least two flaps downwards into the reagent reservoir to clear at least part of the opening of the reagent reservoir. Further aspects of the invention relate to a computer-implemented method for controlling a robotic arm and to an opening tool (200) comprising the cutting tip and the blunt protrusion.
A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.
A multichannel pipetting plate comprises a plurality of connectors arranged in a lattice; wherein each connector is fluidically connectable to a pipetting tip; wherein each connector comprises an interface at which a friction contact between the connector and a foot of the pipetting tip is established; wherein the interfaces of the connectors are arranged in different planes, such that, at least at a border region of the pipetting plate, along each row and along each column of the lattice, at least three consecutive interfaces are arranged in at least two different planes.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
B03C 1/32 - Séparation magnétique agissant sur le milieu qui contient la substance à séparer, p.ex. séparation magnéto-gravimétrique, magnéto-hydrostatique ou magnéto- hydrodynamique
A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.
A method for classifying liquid handling procedures comprises includes receiving measurement data encoding a measurement curve of measurements over time during at least a part of a liquid handling procedure; inputting the measurement data into a neural network; and calculating at least one quality value for the liquid handling procedure with the neural network.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension further has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, and a coating for interacting with a fluid present in a fluid uptake area.
B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
B03C 1/32 - Séparation magnétique agissant sur le milieu qui contient la substance à séparer, p.ex. séparation magnéto-gravimétrique, magnéto-hydrostatique ou magnéto- hydrodynamique
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
39.
PIPETTE TIP EXTENSION, PIPETTE TIP, ASSEMBLY OF PIPETTE TIP AND PIPETTE TIP EXTENSION, AND METHOD OF USE
A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.
A centrifugal processing unit for directing the movement of substances within a sample processing cartridge has a rotor with an accommodation for receiving the sample processing cartridge, the accommodation only allowing a free pivoting motion of the cartridge about a respective pivot axis, wherein each pivot axis is orthogonal to the rotor axis and to a respective force vector of a centrifugal force, a rotor drive to create the centrifugal force, a blocking element, allowing the free pivoting motion of the cartridge in a release position and preventing the free pivoting motion in a blocking position, wherein the blocking element is arranged on the rotor spaced apart above the accommodation is disclosed.
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p.ex. butyromètres
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
42.
CARTRIDGE, DIGITAL MICROFLUIDICS SYSTEM AND METHOD OF CONTROL AND MANIPULATION OF LIQUIDS
A cartridge configured to control and manipulate liquids and to be positioned at a cartridge accommodation site of a digital microfluidics system is disclosed. The digital microfluidics system has a number or array of individual electrodes attached to a first substrate or PCB, a central control unit in operative contact with individual electrodes for controlling selection and for providing a number of individual electrodes that define a path of individual electrodes with voltage for manipulating liquid portions or liquid droplets by electrowetting, and a cartridge accommodation site that is configured for taking up the cartridge.
Devices and corresponding methods for capacitive foam detection in liquid containers are disclosed. The device has a sensor with a measurement electrode having a plurality of sub-electrodes, a bottom plate that is used as a counter electrode for arranging a liquid container, a sensor electronic unit that is connected to the measurement electrode and the bottom plate and is adapted to determine an impedance, in particular a capacitance, between the measurement electrode and the bottom plate, and an evaluation unit, the measurement electrode being arranged substantially perpendicularly to the bottom plate.
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
44.
MIXING APPARATUS, MIXING SYSTEM AND METHOD FOR MIXING SUBSTANCES IN CLOSED CONTAINERS
A mixing apparatus containing a drive unit having a drive and a shaft that is pivotable about a pivot axis and is operatively connected to the drive. A pivotable receptacle is arranged on the shaft, where the pivot axis is oriented essentially horizontally, and the pivotable receptacle has a base plate and at least one retainer spaced therefrom, and the pivotable receptacle is configured in such a way that holders for containers can be inserted between the base plate and the at least one retainer in the direction of the pivot axis.
The invention relates to a pipetting device having tube with an opening at one end for suctioning or discharging a sample fluid, and can be operatively connected to a pressure generation device at the other end. A first electrode is formed on the pipetting device that forms a measuring capacitor together with a second electrode formed by at least one part of the sample fluid and that can be received in the tube and the measuring capacitor is operatively connected to a measuring unit, and the measuring unit is designed to determine a volume of the suctioned or discharged sample fluid according to the capacity of the measuring capacitor. The invention also relates to a fluid processing system having a pipetting device of this type, as well as a method for determining a processed fluid volume during pipetting with a pipetting device of this type.
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01F 22/00 - Procédés ou appareils pour la mesure du volume des fluides ou des matériaux solides fluents, non prévus ailleurs
Pipetting device for pipetting a liquid driven by a gaseous working medium, the pipetting device having at least one pipette connector adapted to attach a pipette at a connection opening at least one pressurizing and/or suctioning pressure source, a gas flow connection between said connection opening and at least one pressure source, a flow restriction defining at least a section of said gas flow connection, a first sensor configured to measure a quantity indicative of the temperature of the flow restriction. The invention is further directed to a gas flow connection element for a pipetting device and to a method of pipetting a liquid volume.
An incubation cassette for reducing liquid evaporation from wells of a microplate that has a frame for receiving a microplate having wells. The frame has a central first opening that is surrounded by an inner wall and the dimensions are designed for the placement of the microplate therein, and an outer wall extends substantially parallel to the inner wall and adjoins the inner wall via an intermediate bottom such that a liquid reservoir for holding a liquid is formed by the two walls and the intermediate bottom, the liquid reservoir surrounding the first central opening. At least a portion of the incubation cassette that forms the liquid reservoir is provided at least in part with at least one transparent portion (TA).
A combinable cavity tray for liquid handling is provided. The combinable cavity tray has at least one cavity for receiving a fluid and at least one passage for leading through a cavity of a second combinable cavity tray and/or for connecting to a pipetting apparatus. The at least one cavity of the combinable cavity tray is formed integrally. An assembly of combinable cavity trays having at least two combinable cavity trays, a method of manufacturing a combinable cavity tray and the use of a combinable cavity tray or of an assembly of combinable cavity trays for liquid handling are provided.
A device for determining a position and/or an extension of a drop in a position determination space, where the device has a camera having an objective and a beam splitter in the recording area of the camera, and the device is designed in such a way that light coming from the position determination space can enter the objective of the camera along a first light path as well as along a second light path, where light along the first light path can be reflected at a first reflector element in the direction of the beam splitter and can be transmitted through the beam splitter towards the objective, and where light along the second light path can be reflected at a second reflector element in the direction of the beam splitter and can be reflected at the beam splitter towards the objective.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A device for controlling an optical recognition unit with the help of a capacitive filling level measurement in liquid containers having a sensor with a measuring electrode, a conductive base plate suitable for arranging at least one liquid container or a carrier unit having at least one receptacle for receiving a liquid container, a sensor electronics unit that is connected to the measuring electrode and the base plate adapted to determine a capacitance between the measuring electrode and base plate, an evaluation unit, and a control unit for controlling the optical recognition unit, is disclosed.
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
A microplate processing device having at least one carriage with a first receptacle for microplates where the at least one carriage is movable in a first horizontal direction, and having at least one lift that is movable in a vertical direction, where the microplates can be removed from and supplied to the carriage, the carriage has a through-opening, the periphery, in the vertical projection, can at least in part be situated horizontally within the periphery of a microplate held in the carriage, and the lift has a second receptacle for microplates, the periphery, in the vertical projection, is situated within the periphery of the through-opening, where the second receptacle can be moved unhindered through the through-opening in the vertical direction.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
54.
Pipetting apparatus with a pipette tube and method for detecting a liquid within an intermediate section of a pipette tube
A pipetting apparatus and method capable of detecting a liquid within an intermediate section of a pipette tube of the pipetting apparatus. The intermediate section is located between an upper section of the pipette tube at which a first electrode is arranged and a lower section at which a second electrode is arranged. The first and second electrodes form a measurement capacitor and are operationally connected to an impedance measurement unit, which is adapted to detect whether liquid, such as a portion of a sample liquid or system liquid, is present within the intermediate section based on the measured impedance or change of impedance, e.g. an increase of the capacitance and/or a decrease of the resistance, of the measurement capacitor caused by a presence of the liquid within the intermediate section.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
55.
Pipetting apparatus, a liquid handling system and a method of controlling pipetting
A pipetting apparatus having a pipette tube with a first end provided with an opening for aspirating and/or dispensing of a sample fluid and a second end operationally connected to a pressure generating means. The pipetting apparatus has at least one measuring unit adapted to determine at least one measurement value of the sample fluid based on the aspirating and/or dispensing of the sample fluid and to provide a sample fluid measurement signal representative thereof to an output of the measuring unit. The pipetting apparatus also has a control circuit operationally coupled to the output of the measuring unit and the input of the pressure generating means, the control circuit is configured to control said pressure generating device based on the sample fluid measurement signal.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 11/04 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p.ex. un tube, une ouverture
G01N 13/02 - Recherche de la tension superficielle des liquides
56.
LABORATORY AUTOMATION DEVICE CONTROL PROGRAM GENERATION WITH OBJECT DETECTION
A method for generating a control program for a laboratory automation device includes: receiving video data displaying a work area of a laboratory assistant, the work area containing a hand-held pipette and containers for receiving a liquid; detecting openings of the containers in the video data and determining positions of the openings; detecting a pipette tip of the hand-held pipette in the video data and determining a movement of the tip; and generating the control program for the laboratory automation device from the movement of the pipette tip with respect to the positions of the openings, wherein the control program is adapted for moving a pipetting arm with a robot pipette of the laboratory automation device with respect to containers of the laboratory automation device accordingly to the movement of the hand-held pipette in the work area.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G05B 19/042 - Commande à programme autre que la commande numérique, c.à d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
A position detector for generating 3D position information of an object in a position determination space for the object. The position detector has a camera with a lens and an image sensor that defines an imaging area with one first light deflecting element arranged in the imaging area as the camera and the at least one light deflecting element are adapted to simultaneously produce on the image sensor at least two images of the position determination space, a first image being produced by light beams deflected at the first light deflecting element, the at least two images differ with respect to the viewing direction of the position determination space.
G01B 11/00 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques
G01B 11/02 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur
G01B 11/03 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur en mesurant les coordonnées de points
A rotary valve comprises a stator member with a planar stator face, the stator member having a plurality of stator channels for conducting a fluid and a rotor member with a planar rotor face facing and in contact with the stator face, the rotor member having at least one rotor channel. The rotor member is rotatable with respect to the stator member, such that in specific rotor positions, the rotor channel interconnects two of the stator channels, such that the stator channels are in fluid communication. One of the stator member and the rotor member is made of ceramics material, wherein the other one of the stator member and the rotor member is made of a polymer material. The ceramics material is coated with a diamond-like carbon (DLC).
F16K 11/074 - Soupapes ou clapets à voies multiples, p.ex. clapets mélangeurs; Raccords de tuyauteries comportant de tels clapets ou soupapes; Aménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont toutes les faces d'obturation se déplacent comme un tout comportant uniquement des tiroirs à éléments de fermeture articulés à pivot à faces d'obturation planes
F16K 25/00 - SOUPAPES; ROBINETS; VANNES; COMMANDES À FLOTTEURS; DISPOSITIFS POUR VENTILER OU AÉRER - Détails constitutifs relatifs au contact entre corps de soupapes ou de clapets et leurs sièges
F16K 31/04 - Moyens de fonctionnement; Dispositifs de retour à la position de repos magnétiques utilisant un moteur
A gripper having a mechanical coupling that can be connected to a pipetting tube, at least one fluid channel extends from the coupling and a negative pressure can be transmitted, the gripper having at least one suction cup that is connected to the coupling through the at least one fluid channel as a result of which the negative pressure can be transmitted from the coupling to the at least one suction cup, and the at least one suction cup in the intended use position of the gripper is aligned such that a rim of a suction cup of the at least one suction cup is aligned in a substantially vertical plane.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
A hollow needle for piercing a closure of a sample vessel, wherein the hollow needle has a cylindrical hollow profile extending along a longitudinal axis and having a tip at a first end thereof, where the hollow needle has a first section that has a tip and a second section that has a larger diameter than the first section, and a transition between the first section and the second section has at least one cutting edge that extends from the first section to the second section.
A transmission module for transmitting torques having a base, a first drive shaft, a second drive shaft parallel thereto, a first output shaft and a second output shaft, both rotatable about a common axis, the axes of the drive shafts are arranged parallel to the axis of the output shafts, a gear unit, where the two drive shafts, the gear unit and the first output shaft are rotatably supported in the base, and the second output shaft is rotatably supported in the first output shaft and the gear unit is designed in such a way that a synchronous rotary movement of the two output shafts can be effected by a rotary movement of the first drive shaft and a relative rotary movement of the two output shafts can be effected by a rotary movement of the second drive shaft.
F16H 37/06 - Combinaisons de transmissions mécaniques non prévues dans les groupes comportant essentiellement et uniquement des transmissions à engrenages ou à friction avec dispositions pour répartir le couple entre plusieurs arbres intermédiaires
B66C 1/44 - Organes de saisie engageant uniquement les faces externes ou internes des objets et leur appliquant des forces de friction
B66C 17/00 - Ponts roulants à chariot transbordeur comportant une ou plusieurs poutres principales sensiblement horizontales dont les extrémités reposent directement sur des roues ou des rouleaux se déplaçant sur une voie soutenue par des supports espacés
F16H 1/36 - Transmissions à engrenages pour transmettre un mouvement rotatif avec engrenages à mouvement orbital à deux engrenages centraux couplés par des engrenages orbitaux
F16H 19/04 - Transmissions comportant essentiellement et uniquement des engrenages ou des organes de friction et qui ne peuvent transmettre un mouvement rotatif indéfini pour convertir un mouvement rotatif en mouvement alternatif et vice versa comportant une crémaillère et pignon
A centrifugal processing unit for directing the movement of substances within a sample processing cartridge having a rotor for receiving the sample processing cartridge, a rotor drive to create a centrifugal force, the centrifugal processing unit having a pivot accommodation and a fix accommodation for receiving the sample processing cartridge that are arranged on the rotor, where each pivot accommodation being adapted to allow a free pivoting motion of the received sample processing cartridge about a respective pivot axis, and each pivot axis being orthogonal to the rotor axis to the respective force vector of the centrifugal force.
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p.ex. butyromètres
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B04B 13/00 - Systèmes de commande spécialement conçus pour les centrifugeurs; Commande à programme des centrifugeurs
65.
Identification device and method for identifying identifiers on and/or features of laboratory objects and/or of samples located therein, and laboratory device having such an identification device
An identification device for identifying identifiers on and/or features of laboratory objects and/or of samples located therein in conjunction with automated laboratory systems or facilities, for example, medical, chemical, or pharmaceutical analysis devices. Barcodes on sample containers, for example, sample tubes, reagent tubs, or microplates are used, for example, as identifiers. An optical recording unit and a mirror are used, the spacing is variable for the detection of laboratory objects, each at different distances, from a recording distance by the optical recording unit is within a depth of field of the optical recording unit. The mirror is used for imaging the laboratory object to be detected on the optical axis. The identification device is substantially simplified, more reliable, and more cost-effective in comparison to known devices that use a zoom lens together with an autofocus unit.
G06F 17/00 - TRAITEMENT ÉLECTRIQUE DE DONNÉES NUMÉRIQUES Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des fonctions spécifiques
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G06K 7/14 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire utilisant la lumière sans sélection des longueurs d'onde, p.ex. lecture de la lumière blanche réfléchie
66.
Centrifugal processing unit including a blocking element
A centrifugal processing unit for directing the movement of substances within a sample processing cartridge, the centrifugal processing unit having a rotor at least one accommodation for receiving the sample processing cartridge, and a rotor drive for rotating the at least one rotor about a respective rotor axis to create the centrifugal force. The centrifugal processing unit has a blocking element allowing the free pivoting motion of the at least one accommodation in a release position when the rotor is rotated in a first direction and preventing the free pivoting motion in a blocking position, when the rotor is rotated in the opposite direction.
A tube guidance means (36) for a laboratory automation system (10) comprises a plate (40) with a guide opening (38); wherein the guide opening (38) has two partial openings (42) which are separated by a land (46) and which are connected by a slot (44); and wherein the partial openings (42) have cutouts (54) for guiding a tube (32), the cutouts (54) being located opposite each other on edges (52) which face away from each other.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
A mixing apparatus, comprising a drive unit (1) with a drive (10) and a shaft (11) which is pivotable about a pivot axis (A) and which is operatively connected to the drive (10), a pivot receptacle (2) which is arranged on the shaft (11), wherein the pivot axis (A) is substantially horizontally aligned, wherein the pivot receptacle (2) comprises a base (20) on which receptacles (21, 22) are provided which extend away from the base (20) and into which holders (3) for containers (7) are insertable.
B01F 11/00 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants
B01F 3/12 - Mélange, p.ex. dispersion, émulsion, selon les phases à mélanger de liquides avec des solides
B01F 15/02 - Mécanismes d'alimentation ou d'évacuation
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
The present invention defines a positioning assembly including a base part (110) and a holder part (120) for holding a device, whereby the assembly further includes a motor (160) for driving a displacement mechanism (150) mounted to the base part. The base part and the holder part are arranged parallel to each other and are connected via a displaceable slide link (140), which is configured to slide on a first guide rail (111) provided on the base part and on a second guide rail (122) provided on the holder part, whereby each guide rail extends in longitudinal direction (z). The slide link (140) is coupled to the displacement mechanism (150), which causes displacement of the slide link relative to the base part in longitudinal direction. Furthermore, the holder part (120) is moveably coupled to the base part (110) via a coupling arrangement which has a first element (115) provided on the base part, a second element (125) provided on the holder part and a third element provided on the slide link (140). The first, second and third elements of the coupling arrangement are configured to engage with each other such that linear displacement of the slide link (140) relative to the base part (110) in one direction causes linear displacement of the holder part (120) relative to the slide link in the same linear direction.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
B25B 11/00 - Porte-pièces ou dispositifs de mise en position non couverts par l'un des groupes , p.ex. porte-pièces magnétiques, porte-pièces utilisant le vide
72.
Cartridge, electrowetting sample processing system and bead manipulation method
A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.
A storage box for plastic pipette tips that has a frame part with two longitudinal walls and two transverse walls that enclose an interior space laterally. The storage box has a support plate arranged on the upper side of the frame part with a large number of bearing openings that plastic pipette tips can be inserted. The storage box also includes a pipette tip contact piece on the underside of the frame part for contacting a plastic pipette tip inserted into one of the bearing openings.
A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.
A method is disclosed for controlling at least one of aspirating and of dispensing a liquid dose or of producing a liquid dose in a pipette or in receptacle, the method having the steps of first loading a first pipette with a first working medium at a first pressure having a first sign with respect to a reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the first pipette, second loading a second pipette with a second working medium at a second pressure having a second sign with respect to the reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the second pipette, discharging a pressure in the first working medium through a controlled valve arrangement to the reference pressure between first and second loadings. A pipetting device is also disclosed.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
The invention relates to a pipetting device having an exchangeable pipette tip for suctioning and discharging fluid volumes for use in automated laboratory systems. The invention relates to a pipetting device having a pipette tip detection unit and for detecting a pipette tip on a pipette device of this type. A detection unit detects whether a pipette tip is connected to the pipette tube or determines a characteristic feature of the connected pipette tip. The pipette tip forms at least one portion of a first electrode when the pipette tip is in electrical operative contact with the pipette tube and, e.g., a pipette tip holder, a contact for setting down the pipette tip holder or a working table over which the pipette tube can be moved forms at least one portion of a second electrode.
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
A connecting element with a screw-in element and a contact element. The screw-in element is pin-shaped and extends along a longitudinal axis, has a thread on its first free end, a drive profile and a reception on its second free end, wherein the contact element is arranged in the reception with its first free end and has a connecting pin on its second free end that extends beyond the screw-in element in the direction of the longitudinal axis, wherein the contact element has a spring that is arranged between the screw-in element and the connecting pin.
H01R 13/10 - Alvéoles destinés à coopérer avec des broches ou lames
H01R 43/20 - Appareils ou procédés spécialement adaptés à la fabrication, l'assemblage, l'entretien ou la réparation de connecteurs de lignes ou de collecteurs de courant ou pour relier les conducteurs électriques pour assembler les pièces de contact avec le socle isolant, le boîtier ou le manchon ou pour les en désassembler
H01R 4/48 - Connexions par serrage; Connexions par ressort utilisant un ressort, un clip, ou un autre organe élastique
A pipetting system having at least one pipette tip receptacle with a pipette tip arranged therein that extends along a vertical axis and at least one gripper having a mechanical coupling, the gripper is coupled to the at least one pipette tip receptacle with the coupling and at least one grip element. The at least one grip element has at least one substantially vertical portion and at least one substantially horizontal portion and the coupling has a body having a through channel that extends along the vertical axis over the entire length of the coupling and the pipette tip extends along the through channel of the coupling.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion
A worktable for a laboratory automation system can include a worktop with a level surface and a support profile for supporting the worktop, bent from a metal sheet The support profile can include a facing edge, and an underside of the worktop can lie directly on the facing edge. The support profile can include at least one reception lug. The worktable can include a bolt-shaped fastener for attaching the worktop on the support profile. The bolt-shaped fastener can project through the worktop and be received in the reception lug.
A47B 13/16 - Supports pour verres, cendriers, lampes, bougies faisant partie des tables
B01L 9/02 - Paillasses ou tables de laboratoire; Leurs garnitures
F16B 5/02 - Jonction de feuilles ou de plaques soit entre elles soit à des bandes ou barres parallèles à elles par organes de fixation utilisant un filetage
F16B 12/30 - Jointure des meubles ou objets similaires, p.ex. masquée de l'extérieur par chevilles, boulons, tenons, brides, clips ou dispositifs similaires pour éléments de meubles métalliques utilisant des écrous filetés
A47B 13/00 - TABLES; BUREAUX; MOBILIER DE BUREAU; MEUBLES À TIROIRS; TIROIRS; PARTIES CONSTITUTIVES GÉNÉRALES DES MEUBLES - Parties constitutives des tables ou des bureaux
A47B 37/00 - Tables destinées à d'autres usages particuliers
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
F16B 19/02 - Chevilles ou manchons pour positionner les parties de machines, p.ex. goupilles coniques à encoche, goupilles de montage, manchons, bagues excentriques d'ajustement
F16B 5/06 - Jonction de feuilles ou de plaques soit entre elles soit à des bandes ou barres parallèles à elles par brides ou clips
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
80.
Cartridge, kit and method for manipulating liquids having biological samples
A cartridge has a container with at least one well, protrusions distributed on the container base side, and a flat polymer film having a lower surface and a hydrophobic upper surface kept at a distance (d) to the container base side by the protrusions. The container and the film are reversibly attachable to a liquid droplet manipulation instrument so that the lower surface of the film abuts at least one electrode array of the instrument. The container enables displacement of at least one liquid droplet from a well onto the hydrophobic upper surface of the flat polymer film and above the electrode array. The liquid droplet manipulation instrument has a control unit with a voltage control and an electrode selector for individually selecting each electrode of the electrode array and for providing the selected electrode with a voltage.
A pipetting device having a lube has an opening al one end for suctioning or discharging a sample fluid and can be operatively connected to a pressure generation device at the other end, a first electrode is formed on the pipetting device and forms a measuring capacitor together with a second electrode formed by at least one part of the sample fluid that can be received in the tube and that measuring capacitor is operatively connected to a measuring unit, and the measuring unit is designed to determine a volume of the suctioned or discharged sample fluid according to the capacity of the measuring capacitor, as well as having a first electrical contact that is designed to create an electrical connection with the working fluid, the first electrical contact can be electrically connected to the measuring unit via a low-resistance converter circuit.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
A method for generating a control program (54) for a laboratory automation device (12) comprises: receiving configuration data (46) of the laboratory automation device (12), the configuration data (46) encoding positions of components (22) in the laboratory automation device (12); generating a three-dimensional model (58) of the components (22) of the laboratory automation device (12) from the configuration data (46), the three-dimensional model (22) additionally including a virtual pipette (60); displaying the three-dimensional model (58) with a virtual reality headset (14); receiving movement data (50) of a motion sensing controller (16) controlled by a user wearing the virtual reality headset (14), the movement data (50) indicating a three-dimensional movement of the motion sensing controller (16) in space; determining a movement of the virtual pipette (60) from the movement data (50) in the three-dimensional model (58) and updating the three-dimensional model (58) according to the movement of the virtual pipette (60); and generating a control program (54) for the laboratory automation device (12) from the movement data (50), wherein the control program (54) is adapted for moving a pipetting arm (30) with a pipette (32) of the laboratory automation device (12) with respect to the components (22) accordingly to the movement of the virtual pipette (60) in the three-dimensional model (58).
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G05B 19/418 - Commande totale d'usine, c.à d. commande centralisée de plusieurs machines, p.ex. commande numérique directe ou distribuée (DNC), systèmes d'ateliers flexibles (FMS), systèmes de fabrication intégrés (IMS), productique (CIM)
The present invention relates to pipette tips for connecting to a pipette tube of a pipetting device that is used for taking up and dispensing fluids. A pipette tip is shaped as a long tube that forms a pipette body with an opening on one of its ends and the other end is designed to connect to the pipette tube. The pipette tip is characterised in that it has an electrode as a volume measuring electrode of a measuring capacitor. The present invention further relates to pipetting devices with a pipette tip, methods for determining the volume of a fluid sample in such a pipette tip, methods for recognising such a pipette tip on a pipetting device, methods for producing such a pipette tip, uses for such a pipette tip and a set of pipette tips.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01F 22/00 - Procédés ou appareils pour la mesure du volume des fluides ou des matériaux solides fluents, non prévus ailleurs
A laboratory automation device (10) includes a plurality of device components (14, 16), which are controlled by digital control commands (26). The digital control commands (26) are generated by a controller (20) of the laboratory automation device (10) from assay definition data (38) defining an assay procedure for the laboratory automation device (10).
G06F 30/33 - Vérification de la conception, p.ex. simulation fonctionnelle ou vérification du modèle
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G05B 17/02 - Systèmes impliquant l'usage de modèles ou de simulateurs desdits systèmes électriques
G06F 30/20 - Optimisation, vérification ou simulation de l’objet conçu
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
85.
Measuring device with injector and spray deflector
A measuring device for the measurement of light signals emitted from samples in wells of a microplate, in particular to a luminescence measuring device for measuring luminescence signals. The luminescence measuring device has a first injector with an injector needle having an outlet end for dispensing a reagent into a well, and a luminescence optical device having an optical axis extending substantially perpendicularly to the microplate and a measuring region surrounding the optical axis. The injector needle extends to below the luminescence optical device and opens with its outlet end into the measuring region. The luminescence measuring device has further a spray deflector arranged between the outlet end of the injector and the luminescence optical device.
G01N 21/15 - Prévention de la souillure des éléments du système optique ou de l'obstruction du chemin lumineux
G01N 21/25 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
The invention concerns pipette tips for connecting to a pipette tube of a pipetting device are used for taking up and discharging fluids. The pipette tip is in the shape of an elongated tube forming a pipette body that has an opening at one end and is designed for connecting to the pipette tube at the other end. The pipette tip has a first electrode as a volume measuring electrode of a measuring capacitor and a second electrode as an immersion detector electrode. The first electrode is located on an outer surface of the pipette body or is embedded in the pipette body, and the second electrode is located at least partially on an inner surface of the pipette body.
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
G01F 22/00 - Procédés ou appareils pour la mesure du volume des fluides ou des matériaux solides fluents, non prévus ailleurs
The present invention relates to a method for determining the position of a robotic arm in an automatic liquid handling system in which a measurement probe with a first electrode is arranged on the robotic arm and, together with a second electrode formed by at least part of a working area or at least part of a container or container carrier forms a measurement capacitor that is operatively connected to a measurement unit for measuring an impedance, in particular a capacitance of the measurement capacitor. The method involves moving the measurement probe along a first path, detecting a first change in the impedance, in particular in the capacitance of the measurement capacitor at a first point on the first path, and defining at least one first reference spatial coordinate for a control unit of the robotic arm on the basis of the first point on the first path.
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01D 5/241 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension en faisant varier la capacité par mouvement relatif d'électrodes de condensateur
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
B01L 9/00 - Dispositifs de support; Dispositifs de serrage
A system 100 and method are provided for imaging a sample in a sample holder. For providing autofocus, a 2D pattern is projected onto the sample holder 050 via an astigmatic optical element 120. Image data 172 of the sample is acquired by an image sensor 140 via magnification optics 150. A difference in sharpness of the two-dimensional pattern in the image data is measured along a first axis and a second axis. Based on the difference, a magnitude and direction of defocus of the camera subsystem is determined with respect to the sample holder. This enables the sample holder, and thereby the sample, to be brought into focus in a fast and reliable manner.
G02B 7/36 - Systèmes pour la génération automatique de signaux de mise au point utilisant des techniques liées à la netteté de l'image
G02B 7/32 - Systèmes pour la génération automatique de signaux de mise au point utilisant un triangle parallactique avec une ligne de base utilisant des moyens actifs, p.ex. un émetteur de lumière
G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
89.
Method for the automated classification of a liquid as well as method for the automated adaption of presettings for a capacitive liquid level measurement
A device which has a deliverable sensor, a container for receiving a liquid, a container environment and a signal processing circuit, the input side of which can be connected circuitry-wise to the sensor. The device is designed to perform a capacitive liquid level measurement in normal operation using the sensor, wherein a threshold value can be predefined for the signal processing circuit for normal operation. The device has a classification module which can be connected with an input side or line connection circuitry-wise to the sensor, is designed to make a capacitive measurement of the liquid in the container using the sensor and can be connected circuitry-wise to the signal processing circuit in order to trigger the specification of a threshold value using the sensor for capacitive measurement of the liquid.
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01F 25/00 - Test ou étalonnage des appareils pour la mesure du volume, du débit volumétrique ou du niveau des liquides, ou des appareils pour compter par volume
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
90.
Transport tool for transporting a laboratory article
A transport tool for transporting a laboratory article using a pipette of a pipetting system, and having a plug-in sleeve at a top end, an article holder at a bottom end, and a connecting part which connects the plug-in sleeve to the article holder. The plug-in sleeve has a side sleeve wall and a bottom which surround an interior space of the plug-in sleeve having a cylindrical or conically tapering shape. The plug-in sleeve further has an upward-facing opening for receiving an end of a pipette of an automated pipetting system. The article holder has a holding element oriented downward away from the connecting part. The holding element having at least two elongated projections which has one or more snap hooks protruding outwards to hook under a storage opening of a pipette tip carrier.
B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
An imaging system and method are provided in which a well of a microplate 050 is imaged by a camera 110 comprising magnification optics 112. The camera is controlled to acquire a series of images of the well with different exposures. The series of images comprise a base image with a base exposure and at least one further image with a larger exposure than the base exposure. The series of images are then merged into an output image which comprises in a center region of the well image content from the base image and at a peripheral region of the well image content from the at least one further image. Advantageously, the output image may allow for better assaying or analysis of the samples in the well than any of the individual images.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.
A transport tool for transporting a laboratory article using a pipette of a pipetting system and having a plug-in sleeve at a top end, an article holder at a bottom end, and a connecting part which connects the plug-in sleeve to the article holder. The plug-in sleeve has a side sleeve wall and a bottom which surround an interior space of the plug-in sleeve having a cylindrical and conically tapering shape. The plug-in sleeve further has an upward-facing opening for receiving an end of a pipette of an automated pipetting system. The connecting part has a top surface which defines the bottom of the plug-in sleeve, is positioned between the interior space of the plug-in sleeve and the article holder. The article holder has a holding plate which is flat and faces downward away from the plug-in sleeve, and further has a flatly acting magnet on the holding plate.
B25J 15/06 - Têtes de préhension avec moyens de retenue magnétiques ou fonctionnant par succion
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
94.
Method and device for detecting a fluid contacting
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
95.
Automated system for maintenance and differentiation of pluripotent stem cells
The present invention relates to the automated maintenance of cells particularly reprogrammed somatic cells into iPSCs to enable the large-scale culture and passaging of human pluripotent stem cells (PSCs) that can be adapted to a Freedom EVO®.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
96.
Pipetting arrangement and method of controlling a pipetting arrangement or of producing liquid product doses
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.
Aspiration of a pipette arrangement is initiated. A sensor arrangement senses a least one prevailing first parameter that is dependent from the effect in the pipette arrangement during initiating and upholding the suctioning action. This at least one parameter is analyzed in an analyzing stage. From a result of this analysis and in a determining stage at least one test criterium TC for at least one further parameter as sensed by the sensor arrangement is determined. In a checking stage there is checked whether this further parameter fulfills the at least one test criterium.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 11/08 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p.ex. un tube, une ouverture en mesurant la pression nécessaire à la production d'un écoulement connu
99.
System for manipulating samples in liquid droplets
A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.
A method for determining the presence or absence of disposable pipette tips in pipette tip carriers on the work area of a laboratory workstation. Each of the pipette tip carriers has a support panel with receiving holes into each of which a disposable pipette tip can be inserted. The laboratory workstation for carrying out the method has a robot arm with at least one pipette which is designed to receive and dispose of disposable pipette tips. The laboratory workstation has a digital camera which is arranged on a support device and is operatively connected to an analyzing unit. The work area of the laboratory workstation can be completely imaged in at least one first direction using the digital camera.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01V 8/00 - Prospection ou détection par des moyens optiques
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