A method of determining a 3D center location of a specimen container on a track. The method includes providing a calibration object on the track; providing an initially calibrated image capture device adjacent to the track; moving the calibration object to at least two different longitudinal positions along the track; capturing a first image with the calibration object located at the first longitudinal position; capturing a second image with the calibration object located at the second longitudinal position; and determining a three-dimensional path trajectory of a center location along the track based at least upon the first image and the second image. The method can be used to determine a 3D center location of a specimen container imaged anywhere within a viewing area. Characterization apparatus and specimen testing apparatus adapted to carry out the methods are described, as are other aspects.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
A method of aligning a component to a structure in a diagnostic laboratory system. The method includes aligning a position sensor to the structure; sensing a position of the component using the position sensor; and calculating the position of the component relative to the structure based at least in part on the sensing. Other methods, apparatus, and systems are disclosed.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
Chemiluminescent acridinium conjugates and compounds capable of forming conjugates are disclosed. These chemiluminescent acridinium conjugates may be used as chemiluminescent tracers in immunoassays for the quantification and identification of certain analytes.
Methods of predicting a fault in a diagnostic laboratory system include providing one or more sensors; generating data using the one or more sensors; inputting the data into an artificial intelligence algorithm, the artificial intelligence algorithm configured to predict at least one fault in the diagnostic laboratory system in response to the data; and predicting at least one fault in the diagnostic laboratory system using the artificial intelligence algorithm. Other methods, systems, and apparatus are also disclosed.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
5.
APPARATUS AND METHODS FOR ALIGNING A ROBOTIC ARM WITH A SAMPLE TUBE CARRIER
Apparatus for robotic arm alignment in an automated sample analysis system includes a robotic arm, a sample tube carrier, a plurality of optical components (including, e.g., one or more cameras), and a controller. The controller is operative to process images received from the optical components to determine a first set of coordinates of a first marker relative to the sample tube carrier and determine a second set of coordinates of a second marker relative to the robotic arm. The controller is further operative to adjust the position of the robotic arm and/or the sample tube carrier in response to an excessive offset between the first and second sets of coordinates. In some embodiments, a positioning tool includes the first and second markers thereon. Methods of robotic arm alignment with a sample tube carrier in an automated sample analysis system are also provided, as are other aspects.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25-hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.
G01N 33/82 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des vitamines
C07K 16/44 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
7.
METHODS OF DETECTING BLOOD CLOTS/DEPOSITS ON BLOOD GAS ANALYZER SENSORS
33) sensor. Kits and systems containing the electrochemical sensor modules are also disclosed, as well as methods of using the electrochemical sensor modules.
The present disclosure includes certain steps in immunoassays, such as immunoassays based on chemiluminescence, which increase assay sensitivity as based on a variety of metrics including increasing signal to noise and decreasing limits of detection. One strategy for these enhancements involves movement, and potential sequestration, of solid phases in one triggering reagent prior to addition of a second triggering reagent for chemiluminescence..
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
9.
SELF-TUNING BUBBLE DETECTOR ASSEMBLIES, CALIBRATION METHODS, AND COMPUTER PROGRAM PRODUCTS FOR DIAGNOSTIC ANALYZERS
A self-tuning optical bubble detector assembly for diagnostic analyzers. The bubble detector assembly has a light emitter operated at a plurality of inputs (i.e., generating a plurality of light intensities) for dry supply line tubing (i.e., having no liquid) and for a wet supply line tubing (i.e., having liquid therein). A plurality of outputs representing light detected through the dry supply line tubing and the wet supply line tubing are generated. Based on the received outputs, a final calibrated setting (e.g., a % duty setting or an I_LED) and a threshold are determined at which to accurately and repeatedly determine if the supply line tubing has liquid or air therein. Further provided are methods of self-tuning an optical bubble detector for diagnostic analyzers and computer program products, as are other aspects.
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G16Z 99/00 - Matière non prévue dans les autres groupes principaux de la présente sous-classe
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic reagents and chemicals for clinical and medical use. Computer software for use with medical diagnostic instruments; computer hardware and computer software for use in operating medical diagnostic instruments for the analysis of body fluids and for use in analyzing the data generated by medical diagnostic instruments for the analysis of body fluids, sold as a unit. Medical diagnostic instruments.
11.
SYSTEMS AND METHODS FOR DETERMINING TEST RESULT ACCURACIES IN DIAGNOSTIC LABORABORY SYSTEMS
A method of determining the accuracy of a test performed by a diagnostic laboratory system includes obtaining one or more first measurements during a first operation of the test performed by the diagnostic laboratory system. One or more second measurements are obtained during a second operation of the test performed by the diagnostic laboratory system. The first measurements and the second measurements are collectively analyzed using a trained model that calculates an uncertainty score for the test based on learned correlations between the first operation and the second operation. The uncertainty score may be used to determine whether the test results can be relied upon or whether the test should be rerun. Other methods and systems are disclosed.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
12.
DEVICES AND METHODS FOR TRAINING SAMPLE CONTAINER IDENTIFICATION NETWORKS IN DIAGNOSTIC LABORATORY SYSTEMS
A method of training a sample container identification network of a diagnostic laboratory system includes obtaining a plurality of data subsets, wherein each data subset is smaller than a full training data set used to train the sample container identification network and includes a plurality of images of one or more sample containers. The sample container identification network is trained on each of the plurality of data subsets to generate a plurality of trained sample container identification networks. Each of the trained sample container identification networks are testing using testing data that includes test images of sample containers, wherein the testing includes identifying the sample containers in the test images. A core data set is selected from one of the plurality of data subsets based on the testing, the core data set for use in training a deployed sample container identification network. Other methods and systems are disclosed.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
G06V 10/84 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les modèles graphiques de probabilités à partir de caractéristiques d’images ou de vidéos, p.ex. les modèles de Markov ou les réseaux bayésiens
13.
METHOD, DEVICE AND SYSTEM FOR ENHANCING IMAGE QUALITY
A method, device and system for enhancing image quality of an image is provided. In one aspect, the method includes illuminating a sample with a light source associated with an imaging device. Further, the method includes simulating a transmission wave at a sensor plane of the imaging device for a light wave from illuminating the sample. Additionally, the method includes determining a phase and amplitude information associated with the light wave based on the transmission wave. The method also includes determining at least one microscope transfer function associated with the imaging device based on the phase and amplitude information. Furthermore, the method includes generating a modified mi-croscope transfer function using a Zernike function based on the at least one microscope transfer function in an iterative procedure and enhancing the image quality associated with the im-age using the modified microscope transfer function.
Disclosed is a blood contamination detection apparatus. The blood contamination detection apparatus comprises a computer-based contamination determining module configured to receive: one or more baseline quantified test results on an uncontaminated blood sample obtained from a patient; one or more quantified test results for one or more analytes of a blood sample or a blood component; and data input on a type of IV fluid infusion that the patient has received that is able to affect the one or more quantified test results. The computer-based contamination determining module comprises a contamination determining routine executable on a computer and configured to compare differences between the one or more baseline quantified test results and the one or more quantified test results against preset threshold difference values and/or directions and provide a contamination output. Sample contamination detection method are provided, as are other aspects.
G01N 21/88 - Recherche de la présence de criques, de défauts ou de souillures
G01N 15/05 - Recherche de la sédimentation des suspensions de particules dans du sang
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
G16B 40/00 - TIC spécialement adaptées aux biostatistiques; TIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p.ex. extraction de connaissances ou détection de motifs
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G01N 15/00 - Recherche de caractéristiques de particules; Recherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
A system and method of tracking vessel movers within a liquid handler system using sparse sensor assemblies. The method includes mapping received sensor signals to pre-characterized functions and determining the positions of the vessel movers with respect to a single sensor from the sensor assembly accordingly. The sensors in the sparse sensor assembly can be positioned to have no or minimal overlap between their sensing ranges.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01R 33/07 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs à effet Hall
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
17.
HYBRIDIZED CONTROL ARCHITECTURE FOR VESSEL MOVER MOVEMENT CONTROL
A system and method for a hybridized control architecture for a liquid handler system. The hybridized control system can control the movement of the vessel movers of the liquid handler system using a hybridized movement control approach that incorporates both position, velocity and current-based control outputs. The control system can further dynamically control the relative degree to which velocity or position-based control is applied to the vessel movers based on the vessel movers' relative positions along the track system.
B65G 43/08 - Dispositifs de commande actionnés par l'alimentation, le déplacement ou le déchargement des objets ou matériaux
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
18.
PIPETTE TIPS, PIPETTE ASSEMBLIES, ASPIRATION AND DISPENSE SYSTEMS, AND METHODS OF PREVENTING PIPETTE TIP STICTION
A pipette tip configured to aspirate and dispense liquids. The pipette has a tip comprising an opening, wherein the pipette has one or more blades having a length extending at least partway from the tip, and at least some of the one or more blades include an acute-angled cutting edge along the length. In some embodiments, the pipette tip is part of a detachable pipette tip having a tip body with a first end configured to detachably couple to a pipette. Other detachable pipette tips, pipette tips, pipette assemblies, aspiration and dispense systems, testing apparatus, and methods of accessing a well through a well cover are disclosed.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
Methods and systems for detecting an obstruction on a sensor of a fluid analyzer, including a method comprising causing a first calibration fluid to contact the sensor to generate signals indicative of a first electric potential of the first calibration fluid; causing a second calibration fluid to contact the sensor to generate signals indicative of a second electric potential of the second calibration fluid; storing a first response slope; causing the first calibration fluid to contact the sensor to generate signals indicative of a third electric potential of the first calibration fluid; causing the second calibration fluid to contact the sensor to generate signals indicative of a fourth electric potential of the second calibration fluid; storing a second response slope; and storing data indicative of an obstruction on the sensor in response to a difference between the first response slope and the second response slope being beyond a threshold.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 37/00 - RECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES - Détails non couverts par les autres groupes de la présente sous-classe
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
20.
VIBRATING PIPETTE TIPS AND METHODS OF PREVENTING PIPETTE TIP STICTION
A pipette assembly configured to aspirate liquid from a well having a cover includes: a pipette including a terminal end; a pipette tip detachably coupled to the terminal end; and a vibration inducer configured to vibrate the pipette tip when at least a portion of the pipette tip is located in the well thus reducing stiction between the cover and the pipette tip. This minimizes the pipette tip from getting detached from the pipette and stuck in the cover. Other systems and methods including vibrating a pipette tip are disclosed.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A tray insert for use with an apparatus configured to analyze a sample is disclosed. The tray insert includes a first surface comprising an elongated channel adapted to receive a reagent strip for sample analysis. Further, the insert includes a second surface, wherein the second surface is in a direction opposite to the first surface. Additionally, the insert includes a hollow enclosure between the first surface and the second surface, wherein the elongated channel on the first surface comprises a plurality of slots and wherein the slots comprise an opening on each end, wherein the opening enters the hollow enclosure.
C12M 1/14 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens fournissant des couches minces ou avec des plateaux à niveaux multiples
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 1/28 - Préparation d'échantillons pour l'analyse
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Reagents for research purposes; chemical reagents for non-medical purposes; kits composed primarily of reagents for in vitro scientific and research use Medical diagnostic reagents; diagnostic reagents for medical use; chemical and biological compounds used as standards or calibrators for clinical medical or medical laboratory uses for the purpose of maintaining and ensuring the accuracy of test results Medical diagnostic test kit comprising one or more diagnostic test assays and a diagnostic test calibrator for diagnostic identification of one or more biomarkers in humans.
23.
HIGH-SENSITIVITY CHEMILUMINESCENCE DETECTION SYSTEMS AND METHODS
A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
24.
APPARATUS AND METHODS OF DETECTING DEFECTS IN MACHINE VISION SYSTEMS
Methods of identifying a defect in a machine vision system. Embodiments of the method include providing a first imaging device having a first field of view; moving a reflective tool through the first field of view; capturing a plurality of images of the reflective tool at different locations in the first field of view using the first imaging device; and analyzing at least one of the plurality of images to identify one or more defects in the machine vision system. Systems and apparatus configured to carry out the methods are provided, as are other aspects.
A method (100) of extracting nucleic acids is disclosed. The method includes receiving a sample containing nucleic acids to be extracted. The method (100) includes lysing cells in the sample to release the nucleic acids. The method (100) also includes introducing the released nucleic acids to a substrate, wherein the nucleic acids bind to the substrate. The method (100) includes washing the substrate bound to the nucleic acids and eluting the nucleic acids from the substrate. The introducing of the released nucleic acids to the substrate, the washing of the substrate bound to the nucleic acids, and the eluting of the nucleic acids are performed in a pipette tip.
Non-limiting embodiments of a system(s) of generating interfering flags to reduce false diagnosis due to interfering conditions present in urinalysis results, and method(s) related thereto.
Systems and methods for dynamic route planning for use with modular liquid handler systems. A route planning algorithm can be utilized to plan routes for the vessel movers of the liquid handler systems in a dynamic manner, without the need for hardcoded routes, so that a route planning system can efficiently transport samples between modules of the liquid handler systems while minimizing risks of collisions and jams. The route planning algorithm can be configured to receive a representation of the liquid handler system configuration and plan routes for the vessel movers accordingly.
G05B 13/02 - Systèmes de commande adaptatifs, c. à d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
G05B 15/02 - Systèmes commandés par un calculateur électriques
Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
G01N 33/60 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées faisant intervenir des substances marquées radioactives
29.
ANALYZER HAVING A TRANSPARENT SHIELD FOR PROTECTING AN IMAGING SYSTEM
A method of receiving an image of a test device through a transparent shield not associated with an imaging system, wherein the transparent shield is positioned within a housing of a reagent analyzer; comparing pixel data of the received image of the test device through the transparent shield to determine a degree of occlusion of the transparent shield; determining whether the degree of occlusion exceeds a baseline value indicative of potential occlusion; and responsive to the degree of occlusion exceeding the baseline value, causing an action selected from a group consisting of: initiating an alert in a form perceivable by a human; storing data indicative of the degree of occlusion detected within the image exceeding the baseline value; initiating a cleaning process configured to clean the transparent shield; and replacing the transparent shield with a replacement transparent shield having a degree of occlusion less than the baseline value.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
30.
Scalable deployment of ontology-based decision trees for clinical decision support and automated clinical workflows
Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G06F 16/31 - Indexation; Structures de données à cet effet; Structures de stockage
G06F 16/36 - Création d’outils sémantiques, p.ex. ontologie ou thésaurus
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
31.
SCALABLE DEPLOYMENT OF ONTOLOGY-BASED DECISION TREES FOR CLINICAL DECISION SUPPORT AND AUTOMATED CLINICAL WORKFLOWS
Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.
G06N 5/01 - Techniques de recherche dynamique; Heuristiques; Arbres dynamiques; Séparation et évaluation
G06N 5/022 - Ingénierie de la connaissance; Acquisition de la connaissance
G06N 5/025 - Extraction de règles à partir de données
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
32.
DEVICES AND METHODS FOR TRAINING SAMPLE CHARACTERIZATION ALGORITHMS IN DIAGNOSTIC LABORATORY SYSTEMS
A method of updating training of an annotation generator of a diagnostic laboratory system includes providing an imaging device in the diagnostic laboratory system, wherein the imaging device is controllably movable within the diagnostic laboratory system; capturing a first image within the diagnostic laboratory system using the imaging device, the first image captured with at least one imaging condition; performing an annotation of the first image using the annotation generator to generate a first annotated image; and updating training of the annotation generator using the first annotated image. Other methods and systems are disclosed.
Methods of troubleshooting non-event malfunctions include providing a database including pre-populated non-event issues and associated corrective actions, receiving search criteria regarding a particular non-event issue via entry of a search string at a user interface, parsing and normalizing the search string into a meta-data schema to produce a normalized search string, searching the database with the normalized search string to generate a listing of one or more particular corrective actions, and receiving the listing of one or more particular corrective actions that are associated with the normalized search string. Apparatus configured to carry out the methods are provided, as are other aspects.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G06F 16/907 - Recherche caractérisée par l’utilisation de métadonnées, p.ex. de métadonnées ne provenant pas du contenu ou de métadonnées générées manuellement
Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and/or conjugates are also disclosed, along with microfluidics devices containing same.
C09B 62/12 - Colorants réactifs, c. à d. colorants formant des liaisons de covalence avec les substrats ou se polymérisant sur eux-mêmes le groupe réactif est directement lié à un hétérocycle à un cycle pyridazine
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
Fluid analyzation devices, methods, and systems are disclosed including an analyzation device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an piezo transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the piezo transducer configured to emit ultrasonic acoustic waves having a first frequency, a second frequency, and a third frequency into and/or to a blood sample within the microchannel, the first frequency configured to begin separation of red blood cells and plasma in the blood sample, the second frequency configured to complete separation of the red blood cells and plasma, and the third frequency configured to rupture cell walls of the blood cells producing a lysed blood sample.
An acoustophoresis device having a sample vessel and a piezo transducer is described. The sample vessel has an outer surface, a microchannel within confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel, such that a blood sample is insertable through the first port into the microchannel. The sample vessel has conductive traces on the outer surface. The piezo transducer is bonded to the outer surface of the sample vessel to form a monolithic structure. The piezo transducer contacts at least one of the conductive traces, the piezo transducer is configured to generate ultrasonic waves inside a sample in the microchannel. The piezo transducer has an excitation signal input and response signal output electrically connected to the at least one of the conductive traces.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 1/28 - Préparation d'échantillons pour l'analyse
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
37.
DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC ASSAY DEVICE
Chromatographic assay devices for detecting the presence of free hemoglobin in a liquid biological sample are disclosed. The device comprises a sample application pad and a chromatographic detection pad, wherein the sample application pad is formed of two layers of material. Medical diagnostics devices for use with the chromatographic assay devices are also disclosed, as well as kits and methods of using the chromatographic assay device and/or medical diagnostics device.
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
G01N 33/558 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet utilisant la diffusion ou la migration de l'anticorps ou de l'antigène
G01N 33/72 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir les pigments du sang, p.ex. l'hémoglobine, la bilirubine
38.
SAMPLE COLLECTION APPARATUS AND METHODS FOR IMMUNOASSAY TESTING
A method of increasing a concentration of an antigen of a respiratory virus is provided. The method includes preparing a sample containing a first concentration of the antigen; contacting the sample containing the first concentration of the antigen to a first material having a negatively-charged surface, thereby capturing an amount of the antigen with the first material; contacting a second material to the first material to transfer the antigen from the first material to the second material, the second material having an ionic strength sufficient to release the captured antigen from the first material into the second material; and obtaining a resulting solution containing the antigen in a second concentration. The second concentration of the antigen in the resulting solution is higher than the first concentration of the antigen in the sample. Numerous other aspects in accordance with this and other embodiments are provided.
The present disclosure relates to a method of determining antibiotic susceptibility of a micro-organism in a sample, the method including: receiving the sample containing the micro-organisms; incubating at least one first portion of the sample with at least one antibiotic and at least one second portion of the sample with no antibiotic; extracting nucleic acid from the at least one first portion of the sample and the at least one second portion of the sample, wherein the nucleic acid is associated with the micro-organisms present in the sample; amplifying the extracted nucleic acid from the at least one first portion and the at least one second portion of the sample; and obtaining the antibiotic susceptibility information associated with the micro-organism from the amplified nucleic acid from the at least one first portion and the at least one second portion of the sample.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
A microfluidic device has a first substrate, a resilient diaphragm, an actuator, and a second substrate. The first substrate has an opening extending therethrough. The resilient diaphragm is secured to a second side and surrounds the opening. The actuator is secured to a first side and surrounds the opening. The first substrate, the resilient diaphragm, and the actuator cooperate to form a gas-tight chamber. The second substrate has a channel formed therein having a first end and a second end. The second substrate is secured to the first substrate. A volume of gas disposed in the gas-tight chamber pressurizes the gas-tight chamber and expands the resilient diaphragm such that the resilient diaphragm is disposed in the channel between the first end and the second end. The resilient diaphragm retracts from the channel to open the channel from the first end and the second when the gas-tight chamber is depressurized.
In some embodiments, a method of determining a viewpoint for optically inspecting a sample within a sample container is provided that includes ( a ) employing a sensor to capture image data of a sample container including a sample, wherein a portion of the sample container includes a label having first and second ends; (b) rotating at lea st one of the sample container and the sensor about a central axis of the sample container so that the sensor capture s image data including at least the first and second ends of the label; ( c ) employing the captured image data to generate an unwrapped image of the sample container; (d) processing the unwrapped image to characterize the label and produce label characterization information; and ( e ) employing the label characterization information to identify a viewpoint through which to optically inspect the sample within the sample container. Numerous other aspects are provided.
H04N 19/167 - Position dans une image vidéo, p.ex. région d'intérêt [ROI]
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
42.
SYSTEM, METHOD AND POINT OF CARE DEVICE FOR IMAGE ANALYSIS OF DIAGNOSTIC ASSAYS
An image analysis system, a method and a point of care device are provided for determining, from an image of a cassette containing a sample, a concentration of one or more target analytes in the sample. The method includes identifying a region of interest (ROI) from the image corresponding to a result viewing area of the cassette, generating a unidimensional (1D) profile of the ROI, and probabilistically determining from the 1D profile, the concentration of the target analyte(s) in the sample based on a statistical model having one or more parameters of the 1D profile varying with respect to time and/or the concentration of the target analyte(s) in the sample.
A sample handler of a diagnostic laboratory system includes a plurality of holding locations configured to receive sample containers. An imaging device is movable within the sample handler and is configured to capture images of the holding locations and sample containers received therein. A controller is configured to generate instructions that cause the imaging device to move within the sample handler and capture images. A classification algorithm is implemented in computer code, and includes a trained model configured to classify objects in the captured images. Other sample handlers and methods of handling sample containers are disclosed.
G01N 1/00 - Echantillonnage; Préparation des éprouvettes pour la recherche
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups.
Methods of troubleshooting non-event malfunctions. The methods include providing a database including pre-populated non-event issues and associated corrective actions, inputting search criteria regarding a particular non-event issue via entry of a search string at the user interface, parsing and normalizing the search string into a meta-data schema to produce a normalized search string, searching the database with the normalized search string to generate a listing of one or more particular corrective actions, and receiving the listing of one or more particular corrective actions that are associated with the normalized search string. Apparatus configured to carry out the methods are provided, as are other aspects.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G06F 16/907 - Recherche caractérisée par l’utilisation de métadonnées, p.ex. de métadonnées ne provenant pas du contenu ou de métadonnées générées manuellement
G06N 5/02 - Représentation de la connaissance; Représentation symbolique
G06F 11/07 - Réaction à l'apparition d'un défaut, p.ex. tolérance de certains défauts
46.
MULTI-LAYER SOFTWARE ARCHITECTURE FOR OPERATING DIAGNOSTIC LABORATORY SYSTEMS
A diagnostic laboratory system includes one or more instruments and a transport system configured to transport sample containers to and from the one or more instruments, wherein each of the sample containers contains a biological sample. A computer is configured to execute a program to control operation of the diagnostic laboratory system. The program has an architecture comprising a plurality of individually replaceable software modules, wherein one or more software modules identify at least one test or plan at least one phase thereof to be performed on the biological sample. Another software module generates instructions to cause one or more of the sample containers to move to or from the one or more instruments in accordance with the at least one test or the at least one phase thereof. Methods of operating a diagnostic laboratory system are also disclosed.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
B65G 47/52 - Dispositifs pour transférer objets ou matériaux entre transporteurs, p.ex. pour décharger ou alimenter
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
A docking assembly for a point-of-care analyzer. The docking assembly comprises an adapter and interface clip. Adapter includes an adapter body attachable to the point-of-care analyzer, the adapter body having an opening and adapter electrical connector. The interface clip is receivable in the opening and includes a clip body and clip electrical connector. Clip electrical connector includes a clip interface member electrically interfaceable with a data and power port of a handheld computing device, and a clip data and power member configured to electrically connect with an adapter interface member. The adapter electrical connector and the clip electrical connector are configured to facilitate charging of the handheld computing device through an electrical connection between at least one adapter charging contact and the clip interface member. Adapters, interface clips, point-of-care assemblies using the docking assemblies, and methods of operating such point-of-care assemblies are provided, as are other aspects.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
G01N 33/483 - Analyse physique de matériau biologique
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
H04W 4/80 - Services utilisant la communication de courte portée, p.ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 10/65 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients stockées sur des supports d’enregistrement portables, p.ex. des cartes à puce, des étiquettes d’identification radio-fréquence [RFID] ou des CD
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing an authentication code. The authentication code has a lot value and a secondary value related to the lot value by a predetermined function assigned to the lot value.
A method for determining an amount of alkylphenol ethoxylate compounds in an aqueous sample is provided. The aqueous sample is subjected to an extraction technique to produce a purified sample, the purified sample is subjected to a chemical cleavage technique to convert alkylphenol ethoxylate compounds in the purified sample to their corresponding alkylphenol compounds and produce a cleaved sample. The cleaved sample is subjected to a liquid chromatography technique to obtain a fraction enriched in alkylphenol compounds from the cleaved sample. The fraction enriched in alkylphenol compounds is ionized under conditions suitable to generate fragment ions detectable by mass spectrometry. The amount of the fragment ions is determined using mass spectrometry, and the amount of the fragment ions is related to the amount of alkylphenol ethoxylate compounds in the aqueous sample.
Methods for determining the presence, severity, and/or predisposition of Idiopathic Pulmonary Fibrosis (IPF) in an individual are disclosed. The methods utilize at least one diagnostic marker of a dynamic process of extracellular matrix synthesis and/or extracellular matrix degradation from said sample. The at least one diagnostic marker may be selected from the group consisting of tissue metallopeptidase inhibitor 1 (TIMP1), hyaluronan (HA), and/or Procollagen Type III N-terminal propeptide (PIIINP).
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
A sensor array is disclosed. The sensor array includes a fluid inlet, a fluid outlet, a flow path extending between the fluid inlet and the fluid outlet; and at least one optimization sensor positioned outside of the flow path of the sensor array and configured to provide at least one performance parameter of the sensor array. The at least one performance parameter having performance data of the sensor array.
Lateral flow assay devices and kits for use in the detection of creatinine and in the detection of hemolysis in a biological fluid sample are disclosed. Methods of making and using the lateral flow assay devices and kits are also disclosed.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/70 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir la créatine ou la créatinine
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
Embodiments provide a fitting for tubing connection, a male fitting assembly, and a torque adaptor. The fitting for tubing connection includes a head including a plurality of first gripping portions, each first gripping portion extending from a top of the head; and a shaft attached to the head, wherein the shaft comprises a plurality of external threads.
F16L 19/025 - Extrémités de tuyaux pourvues de colliers ou de brides formant corps ou non avec les tuyaux, maintenues en contact par un organe vissé les colliers ou les brides formant partie intégrante des extrémités du tuyau
F16L 19/02 - Extrémités de tuyaux pourvues de colliers ou de brides formant corps ou non avec les tuyaux, maintenues en contact par un organe vissé
B25B 13/50 - Clés à écrous; Clés anglaises pour des applications particulières pour travailler des pièces de forme particulière, p.ex. des tubes
54.
COMPUTATIONALLY-EFFICIENT LOAD PLANNING SYSTEMS AND METHODS OF DIAGNOSTIC LABORATORIES
Systems and methods include an optimization-based load planning module including a data-reduction scheme for analyzers of bio-fluid samples. The optimization-based load planning module is executable on a computer server and is configured to optimize assay type assignments across a large number of analyzers based on one or more objectives, such as: load balancing, efficient reagent usage, reduced turn-around-time, reduced quality assurance costs, and/ or improved system robustness. The optimization-based load planning module uses a data-reduction scheme to generate a load plan comprising computer-executable instructions configured to cause a system controller of a diagnostic laboratory system to assign each of the requested test types to be performed over the planning period to one or more selected analyzers in accordance with the one or more preferences or priorities. Other aspects are also described.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
A reagent analyzer comprising an imaging system having a first field of view of a reagent test device and a second field of view of a fluid sample information indicator, and configured to capture a first image depicting the reagent test device and a second image depicting the information indicator; a mirror moveable between a first position outside the first field of view and a second position inside the first field of view and located between the imaging system and the reagent test device, the mirror in the second position reflecting light to produce the second field of view; and a processor executing instructions to: receive the first and second images; analyze the first image to determine calibration information from the information indicator; and analyze the second image to determine constituent presence/absence in the fluid sample applied to the reagent test device, using, in part, the determined calibration information.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
A reagent analyzer having a circuit board, an imaging system and a processor is disclosed. The circuit board has a substrate, and a plurality of conductive leads. The substrate has a first and a second major surface. The first major surface is opposite the second major surface. The substrate has an opening extending between the first major surface and the second major surface. The reagent analyzer also includes an imaging system having a field of view extending through the opening formed in the substrate and configured to capture an image of a wet reagent test device positioned at a read position in the field of view, the image having a plurality of pixels. The processor is configured to receive the image, and to analyze pixels of the image to determine a presence or an absence of a target constituent being in a sample applied to the wet reagent pad.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
F21V 19/00 - Montage des sources lumineuses ou des supports de sources lumineuses sur ou dans les dispositifs d'éclairage
H04N 23/74 - Circuits de compensation de la variation de luminosité dans la scène en influençant la luminosité de la scène à l'aide de moyens d'éclairage
H04N 23/56 - Caméras ou modules de caméras comprenant des capteurs d'images électroniques; Leur commande munis de moyens d'éclairage
G06T 7/90 - Détermination de caractéristiques de couleur
Methods of visualizing sample status within a diagnostic laboratory system are provided. The methods include displaying on a display screen, a visual image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and further to display on the visual image, for a particular selected sample scheduled for testing, status indicators located proximate to the visual images of the analyzers on which the tests are scheduled. The status indicators denote: the testing is completed on one or more analyzers (processed), the testing is currently being conducted on one or more analyzers (current), or the testing has not yet been received on the one or more analyzers (to do). Systems including such sample status indicators are provided as are other aspects.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
G06F 3/14 - Sortie numérique vers un dispositif de visualisation
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
58.
DIAGNOSTIC LABORATORY SYSTEMS, ANALYZER INSTRUMENTS, AND CONTROL METHODS
Methods of controlling diagnostic laboratory systems include providing one or more modules, each of the one or more modules configured to process a specimen container and/or analyze a specimen; providing middleware configured to communicate with the one or more modules, wherein the middleware is configured to generate instructions to change an operational state of at least one of the one or more modules to enabled or disabled; generating, by the middleware, one or more instructions to change the operational state of at least one of the one or more modules; and changing the operational state of at least one of the one or more modules in response to one or more instructions generated by the middleware. Systems including a middleware server configured to carry out the methods are provided as are other aspects.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G05B 15/02 - Systèmes commandés par un calculateur électriques
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
59.
VORTEX GENERATOR FOR AGITATION OF FLUIDS DURING SAMPLE PREPARATION
An apparatus, vortex generator assembly and method for automated cell lysis and nucleic acid purification and processing. The vortex generator assembly includes sample holder having a lysis well, at least one wash well, and an elution well. The vortex generator assembly also includes a sample holder cover having a plurality of vibration rods for creating a vortex in the wells of the sample holder. The apparatus includes motor operating a rotating cam to cause the vibration rods to vibrate and create the vortex in a well holding fluid and magnetic beads, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and disperse the beads in solution, to collect nucleic acids such as DNA.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01F 33/452 - Mélangeurs magnétiques; Mélangeurs avec agitateurs à entraînement magnétique en utilisant des éléments d'agitation flottants indépendants
B01F 33/81 - Combinaisons de mélangeurs similaires, p.ex. avec des dispositifs d'agitation rotatifs dans plusieurs récipients
B01F 31/44 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants avec des agitateurs effectuant un mouvement oscillatoire, vibratoire ou de secousses
B01F 31/441 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants avec des agitateurs effectuant un mouvement oscillatoire, vibratoire ou de secousses effectuant un mouvement rectiligne de va-et-vient
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
An automated diagnostic analysis system includes a plurality of modules for processing and analyzing biological samples, a sample transport system for transporting sample containers to and from each of the modules, and a system controller for workflow planning and execution of sample analyses. To increase functionality of the automated diagnostic analysis system without increasing the floor space of the system, one or more of the modules may be configured to receive one or more functional units each operative to perform an additional action in connection with the sample analyses. The functional unit does not require separate access to the sample transport system, and the system controller is configured to dynamically include the functional unit in the workflow planning and execution of the sample analyses. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
61.
AUTOMATION TRACK CONFIGURATIONS FOR MITIGATING SPILLS AND CONTAMINATION
Systems and methods for passively redirecting liquid contaminants from the active region of riding surfaces of track systems for liquid handler systems, including surface energy gradient, channels, and roughness gradients. The described techniques redirect liquids in a passive manner, without requiring any additional electromechanical components or active control systems that would draw additional power and require additional layers of control architecture to manage.
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
B65G 54/02 - Transporteurs non mécaniques, non prévus ailleurs électrostatiques, électriques ou magnétiques
G01N 21/13 - Transport des cuvettes ou des échantillons solides vers ou à partir de l'emplacement de recherche
62.
ABSORBANCE SPECTROSCOPY ANALYZER AND METHOD OF USE
Absorbance spectroscopy methods and systems are disclosed including a spectroscopy analyzer, comprising: an optical element device positioned to receive an analysis light that passes through a sample of a fluid specimen from an illumination unit, the analysis light including first light in a first light range and second light in a second light range different than the first light range, the optical element device comprising: a housing assembly that defines an internal space; and a dichroic mirror-reflector within the internal space positioned to receive the analysis light, the dichroic mirror-reflector configured to filter the analysis light such that a first portion of the analysis light in the first light range is reflected off the dichroic mirror-reflector as a spectrometer light, and such that a second portion of the analysis light in the second light range passes through the dichroic mirror-reflector as a detector light.
The invention relates to a calibration target (1) for a Fourier ptychographic imaging system (100), comprising at least a first plane (2) and a second plane (4), wherein the first plane (2) and the second plane (4) are parallel to each other and comprise a predefined distance (d, 2a) between each other, wherein the first plane (2) comprises a first calibration structure (22) and the second plane (4) comprises a second calibration structure (24), wherein the first calibration structure (22) is configured to be suitable for centering itself in relation to an optical component (14) and/or a ccaammeerraa (12) of the Fourier ptychographic imaging system (100), and wherein the second calibration structure (24) is configured to be suitable for determining, directly or in projection onto the first plane (2), a position of at least one characteristic or predetermined feature of the first calibration structure (22).
The present disclosure refers to a homogeneous method, apparatus and device for detection of target nucleic acids in a sample. In one aspect, the device includes a magnetic bead. Further, the device includes one or more oligonucleotides bound to the magnetic bead. Additionally, the device includes at least one reporter molecule linked to the one or more oligonucleotides.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
65.
LIPOSOME-CONTAINING DIAGNOSTIC REAGENTS AND METHODS OF PRODUCTION AND USE THEREOF
Diagnostic immunoassay reagent compositions are disclosed that include liposomes having analyte-specific binding element(s) associated therewith. In particular, the analyte-specific binding element(s) includes a transmembrane domain that anchors the element(s) in the lipid bilayer of the liposome; the analyte-specific binding element(s) further includes an extracellular/extramembrane domain that is exposed on the outer surface of the liposome and that comprises a domain that specifically binds to the target analyte. Also disclosed are kits, devices, and systems that contain the diagnostic immunoassay reagent compositions, as well as methods of producing and using the diagnostic immunoassay reagent compositions.
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
66.
INTEGRATED CENTRALIZED AND DECENTRALIZED OPERATION OF AUTOMATED DIAGNOSTIC ANALYSIS SYSTEMS AND METHODS THEREOF
An automated diagnostic analysis system includes a system controller for system-wide workflow planning and execution of sample analyses and also includes decentralized processing capabilities (e.g., one or more second controllers) for determining a work-around, where possible, to a detected fault affecting an analysis of a particular sample. The system controller communicates with system components via a first communication channel, while the second controller communicates with a subset of the system components via a second communication channel. Where a work-around for a detected fault cannot be determined by the second controller, the detected fault is communicated to the system controller for resolution. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/04 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse - Détails du transporteur
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
67.
DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF UPDATING
Diagnostic laboratory systems, methods of operating diagnostic laboratory systems, and methods of updating diagnostic laboratory systems are disclosed. A method of operating a diagnostic laboratory system includes identifying data in the system as identified data; identifying change in a data distribution of the identified data; aggregating data instances pertaining to the change in the data distribution; selecting a subset of the aggregated data to update a processing algorithm in the system; and updating the processing algorithm using the subset of the aggregated data. Other systems and methods are disclosed.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p.ex. pour analyser les cas antérieurs d’autres patients
68.
DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF IMAGING TUBE ASSEMBLIES
A method of synthesizing an image of a tube assembly includes capturing an image of the tube assembly, wherein the capturing generates a captured image. The captured image is decomposed into a plurality of features in latent space using a trained image decomposition model. One or more of the features in the latent space is manipulated into one or more manipulated features. A synthesized tube assembly image is generated with at least one of the manipulated features using a trained image composition model. Other methods and systems are disclosed.
A method of detecting a level of a liquid in a well of a container. The method includes looking up an expected liquid level of the liquid in the well of a container; measuring and recording a measured liquid level of the liquid in the well; changing a level of the liquid in the well based upon an expected amount of the liquid to be added or removed; and calculating a next expected liquid level at least in part based on multi-point filtering. Apparatus for carrying out the method are provided, as are other aspects.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
70.
APPARATUS, METHOD FOR CALIBRATING AN APPARATUS AND DEVICE THEREFOR
An apparatus, a method and a device for calibrating the apparatus is disclosed. The apparatus comprises one or more light sources, at least one image acquisition device for acquiring images; and a device. The device comprises a processing unit, a memory coupled to the processing unit. The memory comprising a calibration module configured to obtain a value of current flowing through each of one or more light sources in real-time, compare the value of current flowing through each of the one or more light sources with a predefined threshold current value, and calibrate color gain value associated with at least one image acquisition device, if the determined value of current for each of the one or more light sources is above the predefined threshold current value.
A system (100) and a method (200) for predicting presence of a disease in a subject is disclosed. In one aspect, the system (100) includes one or more processing units (101), a medical database (112) coupled to the one or more processing units (101), and a disease prediction module (110). The module (110) is configured to receive a plurality of parameters associated with the subject. Additionally, the module (110) is configured to determine a threshold for sensitivity and/or specificity associated with a trained machine learning model. Further, the module (110) is configured to predict using the trained machine learning model the presence of the disease in the subject based on the desired sensitivity and specificity and the plurality of parameters associated with the subject and output the prediction on an output unit (105).
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p.ex. de la grippe
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Computer software for use with clinical diagnostic
instruments used to analyze and interpret data and generate
reports; communications software for connecting laboratories
to a proprietary computer network providing proprietary
laboratory test data; communications software for providing
medical diagnostic information; computer hardware for
medical diagnostic testing in the field of immunoassays. Diagnostic systems used to generate diagnostic test results
and to measure and test blood and other biological samples,
comprised of analyzers for medical diagnostic testing in the
field of immunoassays; medical and clinical diagnostic
analyzers and instruments for use in testing biological
samples for testing in the field of human in-vitro
diagnostics for clinical purposes; medical apparatus for
clinical and medical diagnostic use, namely, sample
processing and analysis of information related thereto for
testing in the field of human in-vitro diagnostics for
clinical purposes. Providing on-line courses in the field of medical laboratory
testing, equipment software usage and laboratory management;
educational and training services, namely, courses in the
field of medical laboratory testing, equipment, software
usage and laboratory management.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Computer software for use with clinical diagnostic
instruments used to analyze and interpret data and generate
reports; communications software for connecting laboratories
to a proprietary computer network providing proprietary
laboratory test data; communications software for providing
medical diagnostic information. Compilation of information into computer databases through
the Internet relating to the conducting transactions for
business purposes, namely, for material ordering and
shipping, inventory management and maintenance, and for
generation of related business reports for clinical and
medical laboratories; business management services. Scientific technological and research services in the field
of human in-vitro diagnostics for clinical purposes in the
field of laboratory testing; providing technical information
in the field of laboratory testing; providing technical
information regarding clinical laboratory instrument usage
and efficiency accessible via a computer database. Medical analysis services for diagnostic and treatment
purposes provided by medical laboratories of persons in the
field of human in-vitro diagnostics; clinical medical
services, namely, technical consultation in the field of
medical testing for diagnostic or treatment purposes.
74.
ESTIMATING PATIENT RISK OF CYTOKINE STORM USING BIOMARKERS
Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A vector representing a state of the patient is generated based on the input medical data. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
A method of patient-centric load planning for a diagnostic laboratory having a plurality of instruments includes receiving a list of patient samples, a list of requested tests to be performed for each of the patient samples, and patient-centric information for the patient providing each patient sample. The received data is used to determine a load plan for the instruments, the load plan including a menu of selected tests assigned to each instrument and an ordering of patient samples according to a priority score based on at least a portion of the electronic health record (EHR) of the patient providing the patient sample. A system for patient-centric load planning includes a plurality of instruments controlled by a system controller and computer server to formulate and execute the load plan.
G06Q 10/06 - Ressources, gestion de tâches, des ressources humaines ou de projets; Planification d’entreprise ou d’organisation; Modélisation d’entreprise ou d’organisation
G06Q 10/0631 - Planification, affectation, distribution ou ordonnancement de ressources d’entreprises ou d’organisations
G06Q 10/0637 - Gestion ou analyse stratégiques, p. ex. définition d’un objectif ou d’une cible pour une organisation; Planification des actions en fonction des objectifs; Analyse ou évaluation de l’efficacité des objectifs
76.
ESTIMATING PATIENT RISK OF CYTOKINE STORM USING KNOWLEDGE GRAPHS
Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A knowledge graph is computed based on the input medical data. A vector representing a state of the patient is generated based on the knowledge graph. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
77.
SEALING SYSTEM BETWEEN A MANIFOLD AND A LIQUID CONTAINER
A sealing system is provided that includes a liquid container configured to hold a liquid. The liquid container defines an opening having an inner circumferential sealing surface surrounding the opening, a manifold through which liquid is supplied to and/or removed from the liquid container. The manifold includes a sealing protrusion having an outer circumferential sealing surface, which is curved along a longitudinal axis. In a connected state, the manifold is located on the opening to supply liquid to, or to remove liquid from, the liquid container. The sealing protrusion extends into the opening, and the outer circumferential sealing surface contacts the inner circumferential sealing surface to form a seal between the manifold and the liquid container. In an unconnected state, a circumferential length of the outer circumferential sealing surface is larger than a circumferential length of the inner circumferential sealing surface.
A tiltable display screen assembly of a diagnostic analyzer. The tiltable display screen assembly includes a tiltable support interconnectable to a hand-held device including a display screen, a multi-angle adjuster having adjustment features, and a tilting screen mechanism pivotable relative to the tiltable support. The tilting screen mechanism includes a shaft, one or more moveable paddles coupled to the shaft, an adjustment member depending from the shaft configured to engage with the adjustment features of the multi-angle adjuster in order to adjust a tilt angle of the tiltable support and the display screen of the hand-held device. Diagnostic analyzers including the tiltable display screen assembly and methods for adjusting tilt angle of a display screen of a diagnostic analyzer are described, as are other aspects.
F16M 13/00 - Autres supports ou appuis pour positionner les appareils ou les objets; Moyens pour maintenir en position les appareils ou objets tenus à la main
E04G 3/00 - Echafaudages essentiellement supportés par le bâtiment, p.ex. réglables en hauteur
F16M 11/14 - Moyens pour la fixation des appareils; Moyens permettant le réglage des appareils par rapport au banc permettant la rotation dans plus d'une direction avec articulation à rotule
79.
Portion of a display screen with a graphical user interface having a progress indicator
An assembly for use in a medical diagnostic device and system for analysis of one or more samples is disclosed. In one aspect of the invention, the assembly includes at least one extendable sample tray configured to hold the one or more samples. Additionally, the assembly includes at lease one holding unit coupled to the at least one extendable sample tray, wherein the holding unit is configured to hold a calibration marker. Furthermore, the extendable sample tray and the holding unit are arranged in the same plane and when the extendable sample tray is extended, the at least one holding unit is brought in a field of view of an image capturing unit.
A reagent strip and a reagent analyzer for reading the reagent strip is described. The reagent strip includes a substrate, at least one reagent pad positioned on the substrate, and a photo luminescent phosphor spot positioned at a fixed location on the substrate. The photo luminescent phosphor spot is formulated to exhibit a predetermined addressable attribute.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
84.
DEVICES AND METHODS FOR PLASMA SEPARATION AND METERING
Devices, assemblies, and kits are disclosed for separating and/or metering a plasma sample from a patient's liquid test sample. Also disclosed are methods of producing and using same.
G01N 33/80 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir les groupes ou les types sanguins
G01N 33/547 - Résine synthétique avec un antigène ou un anticorps liés au support par l'intermédiaire d'un agent de pontage
Analyzers and methods of use are disclosed, including a blood analyzer comprising a light source to transmit an optical signal; a detector to generate data indicative of optical signal intensity; a transparent sample vessel between the light source and the detector; a dispensing device to pass a first portion of the blood sample comprising whole blood or lysed blood into the vessel at a first instance of time, and to pass a plasma portion of the blood sample into the vessel at a second instance of time; a controller to cause a processor to obtain first and second data generated by the detector, the first data indicative of the optical signal passing through the first portion of the blood sample and the second data indicative of the optical signal passing through the plasma, to determine a total absorbance spectrum in which the first data is adjusted by the second data.
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
Non-limiting embodiments of a methodology of validating accuracy and precision determinations of a new urine sediment analyzer, and method(s) related thereto.
G01N 33/493 - Analyse physique de matériau biologique de matériau biologique liquide d'urine
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet
G01N 15/14 - Recherche par des moyens électro-optiques
88.
BIOLOGICAL SAMPLE ANALYZER WITH AUTOMATIC THERMAL COOLING ADJUSTMENT FOR ALTITUDE
A method and biological sample analyzer is described that adjusts airflow within a housing based upon altitude. A first volume of air is moved by at least one fan within a housing of a biological sample analyzer. A temperature of the first volume of air is measured within the biological sample analyzer with a temperature sensor within the housing of the biological sample. Power output of at least one heater positioned within the housing of the biological sample analyzer is measured. The measured power output of the at least one heater is analyzed at the measured temperature within the biological sample analyzer. And, the fan is adjusted to move a second volume of air different from the first volume of air by comparing the measured power output of the at least one heater and expected power output of the at least one heater.
A61K 31/7012 - Composés ayant un groupe carboxyle libre ou estérifié, lié directement ou par une chaîne carbonée, à un atome de carbone du radical saccharide, p.ex. acide glucuronique, acide neuraminique
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
90.
AUTOMATIC LIQUID ANALYTICAL REAGENT DISPENSING APPARATUS, ANALYTICAL ASSAY REACTION CARTRIDGES AND KITS, AND METHODS OF USE RELATED THERETO
Analytical assay reaction cartridges are disclosed that include a reagent tray containing a liquid reagent disposed therein and a flexible cover removably attached thereto. The flexible cover has a portion that extends beyond the reagent tray and that forms a tab portion extends through an opening in a lid member of the cartridge in order to facilitate removal of at least a portion of the cover and release of the liquid reagent. Also disclosed are analytical assay reaction kits that include the cartridges and diagnostic instruments for use with the analytical assay reaction cartridges/kits, as well as methods of making and using the cartridges/kits.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 33/72 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir les pigments du sang, p.ex. l'hémoglobine, la bilirubine
A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.
A wash station for use in a clinical analyzer of an in vitro diagnostics (IVD) environment for cleaning a probe comprises a basin, a vertically-elongated conduit, an inlet port, and a helix insert. The vertically-elongated conduit is attached to the interior of the basin. The inlet port is connected to a bottom portion of the basin. The inlet port is sized to receive and secure a wash feed line that propels a wash fluid upward through the vertically-elongated conduit. The helix insert is positioned within the vertically-elongated conduit and sized to allow insertion of the probe through a center portion of the helix insert for cleaning. The helix insert causes the wash fluid to flow in a helical shape around the probe as it is transported through the vertically-elongated conduit, thereby cleaning the probe.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
B08B 3/04 - Nettoyage impliquant le contact avec un liquide
93.
COMBINED TOTAL IG AND IGG IMMUNOASSAYS FOR SARS-COV-2
Methods for determining if a patient is positive for COVID-19 infection are provided, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 total immunoglobulin antibodies (tAb) and anti-SARS-CoV-2 IgG antibodies in a patient sample. The two results are combined to provide optimal sensitivity and specificity for the COVID-19 assay. Also disclosed are kits and microfluidic devices for use in the methods.
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
94.
SENSOR ASSEMBLY WITH WICKING MEMBER FOR LIQUID JUNCTION WET UP
A sensor assembly for a bodily fluid analyzer includes a reference electrode container containing a reference electrode, a membrane capable or configured to be in fluid communication with the reference electrode container; and a wicking member capable or configured to be in fluid communication with the reference electrode container. The wicking member is configured to draw a reference fluid contained in the reference electrode container towards the membrane when the membrane and the wicking member are exposed to the reference fluid.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
G01N 27/403 - Ensembles de cellules et d'électrodes
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
95.
REFLEX TEST FOR IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
Kits, microfluidics devices, and methods are disclosed for determining if a patient is positive for COVID-19 infection, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 antibodies in a patient sample. The kits, microfluidics devices, and methods incorporate the use of a reflex test within the reagent cartridge for the major anti-SARS-CoV-2 antibody assay, wherein the minor assay of the reflex test is employed when the result obtained in the major assay is above a baseline index. The reflex test (i.e., minor assay) utilizes at least one reagent that is different from the reagents utilized in the major assay.
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
G01N 33/541 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec séparation du complexe immunologique de l'antigène ou de l'anticorps non liés faisant intervenir un réactif de précipitation faisant intervenir un double ou un deuxième anticorps
Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
98.
Fluid metering device with reduced cross contamination
Embodiments provide a fluid metering device, including: a first fluid supply port for receiving a first fluid; a first fluid dispense port for dispensing the first fluid; a second fluid supply port for receiving a second fluid; a second fluid dispense port for dispensing the second fluid; a waste discharge port for discharging a mixture of the first fluid and the second fluid; a valve assembly including a plurality of valves; a manifold connected to the metering pump, wherein the manifold includes a plurality of fluid channels, and the manifold is used for communicating between the valve assembly and each port; a first tube connected between the second valve and the third valve for accommodating the mixture or the first fluid; and a second tube connected between the third valve and the fourth valve for accommodating the second fluid.
G01F 15/00 - MESURE DES VOLUMES, DES DÉBITS VOLUMÉTRIQUES, DES DÉBITS MASSIQUES OU DU NIVEAU DES LIQUIDES; COMPTAGE VOLUMÉTRIQUE - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p.ex. pour l'indication à distance
G01F 11/12 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte avec chambres de mesure se déplaçant au cours de l'opération du type à soupapes, c. à d. que la séparation est effectuée par des mouvements étanches aux fluides ou aux poudres
G01F 15/12 - Dispositions pour le nettoyage; Filtres
G01F 15/18 - Supports ou moyens de raccordement pour les compteurs
99.
QUANTITATION OF FUNCTIONAL GROUPS ON SOLID SUPPORTS
Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.
G01N 33/531 - Production de matériaux de tests immunochimiques
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
G01N 33/536 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide
100.
SYSTEM AND METHOD FOR CALIBRATING SYSTEM PARAMETERS FOR IMAGE RECONSTRUCTION
A computer implemented method, an imaging device, an image reconstruction system and a computer program product, for calibrating system parameters of the image reconstruction system are provided, and include obtaining low resolution captured images by illuminating a sample with light source(s), obtaining a high resolution representation of the captured images based on the system parameters and the captured images, generating an approximate function based on the high resolution representation and the captured images, wherein the approximate function is a function of system parameters, and generating an updated set of system parameters by optimizing the approximate function. The computer implemented method, the imaging device, the image reconstruction system, and the computer program product enhance speed of calibration of the image reconstruction system by orders of magnitude, thereby, enabling noise and artifact free microscopic imaging in a robust way for the lifetime of the microscope.
