Provided are methods of cleaning an electrode sub-system. In some embodiments the method of cleaning an electrode sub-system involves providing a cleaning composition comprising: (i) one or more cleaning enzymes; (ii) one or more pH modulators; (iii) one or more matrix components; (iv) one or more buffer components; and (v) one or more preservatives, where the cleaning composition has a pH range of from about 7.2 to about 7.4. This method further involves flowing the cleaning composition through the electrode sub-system, wherein the electrode sub-system comprises an inlet port, one or more sensors, an outlet port, and a fluid flow channel connecting the inlet port, the one or more sensors, and the outlet port.
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
In some embodiments, a method of operating a plurality of diagnostic engines is provided. The method of operating includes receiving, via an instrument data manager (IDM) in communication with a plurality of diagnostic engines, a selection of one of the plurality of diagnostic engines for testing a sample of a patient; employing the IDM to disable at least one of the plurality of diagnostic engines that was not selected; prior to displaying a test result from the selected diagnostic engine for the sample of the patient, requiring entry of at least one of patient information and sample information; and after receiving entry of the patient information or sample information, employing the IDM to enable any disabled diagnostic engine. Numerous other embodiments are provided.
G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
G16H 40/00 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
3.
APPARATUS AND METHOD FOR TRANSFERRING A FLUID SAMPLE FROM A FLUID SAMPLE COLLECTION APPARATUS TO A LIQUID SAMPLE ANALYZER
An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, an inner surface defining an internal chamber, and an external surface defining at least a portion of a chromatographic assay chamber in fluid communication with the internal chamber. The first end has an inlet opening with a clot catcher extending across the inlet opening upstream of the passage and the second end has an outlet opening. A chromatographic assay assembly is housed in the chromatographic assay chamber for detecting presence of free hemoglobin in the fluid sample.
The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences are also provided assembled as kits that can be used to amplify and detect or sequence HCV NS3.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
5.
DERIVATIVES, IMMUNOGENS, AND ANTIBODIES AND USE OF THE SAME IN DETECTION OF ECSTASY-CLASS COMPOUNDS
Haptens and immunogens for ecstasy-class compounds (enactogens) and antibodies raised against the haptens and immunogens are provided herein. The haptens and immunogens include MDA or derivatives thereof conjugated via a linker to an immunogenic carrier or a label. The antibodies raised against the haptens and immunogens recognize MDA and MDMA with the same or similar efficiency and do not cross-react or exhibit limited cross-reactivity to non-ecstasy-class compounds. Also provided are kits including the haptens or immunogens and antibodies raised against the compounds as well as methods for detecting ecstasy-class compounds in a sample.
A method and system for replenishing refrigerated consumables by a mobile connected autonomous refrigerator includes receiving a notification triggered by a laboratory instrument that a refrigerated consumable used by the laboratory instrument is depleted; autonomously navigating to a refrigerated storage; retrieving the refrigerated consumable and placing it in the mobile refrigerated unit; autonomously moving to the laboratory instrument that triggered the notification; and alerting an operator to retrieve the refrigerated consumable from mobile refrigerated unit and load it into the laboratory instrument.
A sensor assembly enabling hemolysis detection with a diagnostic analyzer. The sensor assembly can be included in a diagnostic cartridge that may be coupled to the diagnostic analyzer and a sample fluid can be delivered thereto. The sensor assembly includes a main oxygen sensor configured to provide a first measurement and a modified oxygen sensor including an oxidant configured to oxidize hemoglobin iron to methemoglobin and configured to provide a second measurement. A hemolysis detection module of the diagnostic analyzer provides a level of hemolysis in the sample based on a difference between the first measurement and the second measurement. Numerous other diagnostic analyzers, diagnostic cartridges, and detection methods are provided.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
8.
LAMINATE URINALYSIS ASSAY STRIP AND METHODS OF PRODUCING AND USING SAME
A laminated test strip device for detecting the presence of a plurality of target analytes in a biological sample is disclosed. The laminated test strip device is formed of a plurality of laminated layers of material that control sample flow and sample metering. Methods of producing and using the laminated test strip device are also disclosed.
A method of determining coding patterns for light sources of an FPM system is provided that includes determining a coding matrix that specifies light source patterns for multiplexed low resolution images. Multiplexed low resolution images are generated using the coding matrix. High resolution amplitude and phase reconstruction is performed using an FPM algorithm and the multiplexed low resolution images. A total loss function that includes an exclusivity coupling regularization term that promotes diversity of light source patterns and sparse groupings of light sources within light source patterns of the coding matrix is computed. The method also includes determining if coding matrix optimization is complete. If the coding matrix optimization is complete, the method includes storing the optimized coding matrix for use by the FPM system and/or employing the optimized coding matrix during use of the FPM system.
A method of analyzing inventory in a diagnostic laboratory system includes capturing an image of a plurality of inventory items used in a diagnostic laboratory system, wherein the capturing generates image data; analyzing the image data to identify one or more inventory items; and generating instructions to cause a printer to print one or more identification tags in response to the analyzing, wherein each of the one or more identification tags includes identification data that identifies one of the one or more inventory items. Other methods and systems are disclosed.
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G06K 17/00 - Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups , e.g. automatic card files incorporating conveying and reading operations
An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 1/00 - Sampling; Preparing specimens for investigation
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
12.
NANOPARTICLES COMPRISING POLYMERIZED GAMMA GLOBULIN AND METHODS OF PRODUCTION AND USE THEREOF
Diagnostic immunoassay reagent compositions are disclosed that include nanoparticles formed of polymerized gamma globulin. The nanoparticles have at least one functional moiety on a surface thereof, and at least one analyte-specific binding partner is attached to the nanoparticles through the at least one functional moiety. Also disclosed are kits, devices, and systems that contain the diagnostic immunoassay reagent compositions, as well as methods of producing and using the diagnostic immunoassay reagent compositions.
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
An apparatus comprises a barrel and a colorimetric assay assembly. The barrel has a sidewall defining a portion of a colorimetric chamber that is in fluid communication with an internal chamber defined by an inner surface. The colorimetric assay assembly, housed in the colorimetric chamber, comprises a sample application pad to receive a fluid sample and a colorimetric detection pad to visualize a presence of free hemoglobin. The sample application pad is formed of a prefiltration layer and a filtration layer. The prefiltration layer comprises a distal surface having a first wetting property and a hydrophilic receiving surface having a second wetting property less than the first wetting property and is configured to receive the fluid sample and convey at least a portion of the fluid sample to the filtration layer. The filtration layer is porous to plasma and the free hemoglobin and not porous to red blood cells.
Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.
Methods of predicting failures of in vitro diagnostic instruments include monitoring, with one or more monitoring devices associated with one or more components of the in vitro diagnostic instrument, one or more condition-based maintenance (CBM) parameters of the in vitro diagnostic instrument, providing the one or more condition-based maintenance parameters to a local database, transmitting condition-based maintenance data to a remote service location, storing the condition-based maintenance data at the remote service location, analyzing the condition-based maintenance data according to a failure prediction engine including failure prediction criteria, and performing an action based on predefined deviation from the failure prediction criteria. Apparatus configured to carry out the methods are provided, as are other aspects.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A method (200), and a device (100) for determining onset of sepsis is provided. In one aspect, the method (200) includes receiving at least one medical dataset associated with the patient, wherein the medical dataset comprises a plurality of features. Further, the method (200) includes extracting one or more features from the medical dataset, wherein the one or more features comprises parameters associated with the patient which are indicators of sepsis. Additionally, the method (200) includes imputing at least one missing value in the medical dataset, wherein the missing value is associated with the features in the medical dataset. The method (200) also includes determining an output parameter indicative of the onset of sepsis in the patient by using the one or more features and the at least one missing value in the medical dataset as an input for one or more trained machine learning model (700). Furthermore, the method (200) includes generating an alert (ALT) indicating the onset of sepsis in the patient if the output parameter fulfills a pre-defined criterion associated with sepsis.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
17.
COMPREHENSIVE ACTION PLAN RECOMMENDATIONS FOR MEDICAL MACHINES USING TRANSFORMER NETWORKS
Systems and methods for generating a predicted event log are provided. A time series resulting from a test of a medical machine is received. The time series is encoded using an encoder of a transformer network. A predicted event log for the medical machine is generated based on the encoded time series using a decoder of the transformer network. The predicted event log comprises predicted events and associated action plan recommendations. The predicted event log is output.
G06N 3/04 - Architecture, e.g. interconnection topology
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
18.
METHODS AND APPARATUS ADAPTED TO IDENTIFY 3D CENTER LOCATION OF A SPECIMEN CONTAINER USING A SINGLE IMAGE CAPTURE DEVICE
A method of determining a 3D center location of a specimen container on a track. The method includes providing a calibration object on the track; providing an initially calibrated image capture device adjacent to the track; moving the calibration object to at least two different longitudinal positions along the track; capturing a first image with the calibration object located at the first longitudinal position; capturing a second image with the calibration object located at the second longitudinal position; and determining a three-dimensional path trajectory of a center location along the track based at least upon the first image and the second image. The method can be used to determine a 3D center location of a specimen container imaged anywhere within a viewing area. Characterization apparatus and specimen testing apparatus adapted to carry out the methods are described, as are other aspects.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
A method of aligning a component to a structure in a diagnostic laboratory system. The method includes aligning a position sensor to the structure; sensing a position of the component using the position sensor; and calculating the position of the component relative to the structure based at least in part on the sensing. Other methods, apparatus, and systems are disclosed.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
The present disclosure includes compounds, kits, and assay procedures for use in determining the levels of certain types of drugs in samples that contain specific binding proteins for the drugs. The present disclosure includes analog compounds useful for displacing the drugs from their endogenous binding proteins, and kits including same, as well as methods that utilize these displacers as binding competitors in pharmaceutical assays.
Compositions are disclosed that include acridinium esters of Cyclosporine A or C. Also disclosed are kits containing same and methods of producing and using same.
A method of Fourier ptychography microscopy (FPM) that includes obtaining images of a sample using an FPM system is provided. The method includes storing the images in a memory, uploading the images to a graphics processing unit (GPU), and performing FPM reconstruction using the GPU to generate a reconstructed image. The FPM reconstruction includes performing portions of the FPM reconstruction in parallel on the GPU to reduce FPM reconstruction time.
The present disclosure provides workflows, methods, and systems for performing syndromic polymerase chain reaction (PCR) testing with random and on demand access to both patient samples and assays. The embodiments described herein enable flexible and customized testing of multiple, individual targets for different individual patients. The present embodiments also provide for eluate harvesting and storage for parallel and/or reflex testing. The methods and systems in the present disclosure may enable greater flexibility, faster turnaround times and higher efficiency with lower costs for PCR testing.
An automated analyzer is described. The analyzer includes a housing, a consumable insert, a consumable support device, a reader and a control system. The housing has a sample port. The consumable insert has a consumable insert type and an identification component and receives a consumable. The consumable support device is disposed within the sample port, supports the consumable insert, and is moveable to a testing position within the internal cavity. The consumable support device has an identifier component configured to identify the consumable insert type based in part on the identification component and configured to output a first data signal indicative of the consumable insert type. The reader outputs a second data signal indicative of a reading from the consumable. The control system receives the first and second data signals, and interprets the second data signal based on the first data signal.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
25.
DIAGNOSTIC INSTRUMENTS HAVING MULTIPLE ILLUMINATION SOURCES AND METHODS THEREOF
A method of operating a diagnostic instrument includes illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first period and capturing a first image of the imaging location illuminated by the first light. The method further includes illuminating the imaging location of the diagnostic instrument with second light having a second spectrum for a second period, the second spectrum being more destructive to a chemical configured to be received in the diagnostic instrument than the first spectrum; and capturing a second image of the imaging location illuminated by the second light. Other methods and diagnostic instruments are disclosed.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
G01N 33/487 - Physical analysis of biological material of liquid biological material
26.
DIAGNOSTIC INSTRUMENTS HAVING SORTING CAPABILITY AND SORTING METHODS THEREOF
Diagnostic instruments and methods of operating diagnostic instruments are provided. Methods of operating a diagnostic instrument includes providing the diagnostic instrument having one or more modules, wherein the one or more modules are configured to analyze specimens; providing a specimen sorter coupled to the diagnostic instrument; and sorting specimens into at least first group and a second group, wherein specimens in the first group are to be analyzed by at least one of the one or more modules, and specimens in the second group are not to be analyzed by any of the one or more modules. Other sorting methods and diagnostic instruments are provided.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
27.
MONOVALENT ION SELECTIVE ELECTRODE SENSORS, MEMBRANE COMPOSITIONS, AND METHODS TO REDUCE BENZALKONIUM INTERFERENCE FOR DIAGNOSTIC ANALYZERS
A polymeric ion selective electrode (ISE) sensor for use in blood gas analyzers for blood gas testing, as well as polymeric membranes for same, are disclosed. The polymeric ion selective electrode sensor comprises a polymeric membrane that is selective for a monovalent cation and that has a chemical composition containing a boron-containing salt and at least one monovalent selective ionophore. Also disclosed are polymeric ion selective membranes and methods of minimizing benzalkonium (BK) interference in an ion selective electrode sensor are provided, as are other aspects.
Systems and methods of generating an optimal physical layout of an automated laboratory diagnostic system may include generating a tentative physical layout based on laboratory requirements, simulating sample testing in the automated laboratory diagnostic system using the tentative physical layout, repeating the generating of a tentative physical layout in response to the simulating not meeting one or more laboratory objectives, and outputting a final physical layout in response to the simulating meeting the laboratory requirements and the one or more laboratory objectives. Numerous other aspects are provided.
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G06N 5/00 - Computing arrangements using knowledge-based models
A method of characterizing a specimen to be analyzed in an automated diagnostic analysis system provides an HILN classification (hemolysis, icterus, lipemia, normal) of the specimen along with a basis for that determination. The method includes assigning a hash code to each training image of a sample specimen used in the characterization training process. In response to an HILN determination for a test specimen, the method can retrieve via the hash code one or more of the closest matching training images upon which the HILN classification is based. The one or more of the closest matching training images can be displayed alongside of the one or more images of the test specimen. Quality check modules and systems configured to carry out the method are also described, as are other aspects.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
30.
DEVICES AND METHODS FOR TRANSPORTING SAMPLE CONTAINERS IN DIAGNOSTIC LABORATORY SYSTEMS
A method of operating a diagnostic laboratory system for analyzing a biological sample is provided. The method includes providing a track in the diagnostic laboratory system, wherein the track extends between a plurality of instruments; providing a plurality of sample carriers movable on the track; and modeling in software the track as a plurality of blocks, wherein each block limits the number of sample carriers therein and includes a movement pattern that indicates permitted directions in which sample carriers may move into and out of the block. The method includes communicating a vacancy of a first block and then moving a sample carrier to the first block from a second adjacent block in response to the communicated vacancy. Other methods and systems are disclosed.
Reagents, kits, and microfluidics devices are disclosed for detecting the presence and/or concentration of antibodies directed to microorganisms in human biological samples. Also disclosed are methods of production and use of the reagents, kits, and microfluidics devices. Anti-human immunoglobulin antibodies are utilized as a reagent in a bridging immunoassay for detection of the microorganisms.
A method of characterizing a specimen and specimen container to be analyzed in an automated diagnostic analysis system. The method can provide a segmentation determination and/or an HILN determination (hemolysis, icterus, lipemia, or normal) of the specimen while protecting patient information. The method includes capturing an image of a specimen container via an image capture device, identifying a label affixed to the specimen container in the captured image via an anonymization network, and editing the captured image via the anonymization network to mask some or all information present in the label so that it is removed from the captured image. Quality check modules and systems configured to carry out the method are also described, as are other aspects.
A method of characterizing a specimen to be analyzed in an automated diagnostic analysis system provides a segmentation determination and/or an HILN (hemolysis, icterus, lipemia, normal) determination of the specimen while providing characterization training updates based on the accuracy and/or confidence in the determinations. The method includes identifying an incorrect or low confidence segmentation or HILN determination, forwarding the incorrect or low confidence determination from the HILN network to a database, and providing one or more training images to the HILN network based on the incorrect or low confidence determination. Quality check modules and systems configured to carry out the method are also described, as are other aspects.
A method of operating a diagnostic laboratory system for analyzing a biological sample includes modeling in software a track in the diagnostic laboratory system as a plurality of blocks. At least one test to be performed on a biological sample is identified. A first software module is used to identify one or more instruments in the diagnostic laboratory system to perform the test, wherein the first software module is part of a program comprising a plurality of individual software modules in communication with each other. A second software module of the program is used to generate transport instructions to transport the biological sample via a sample container to the one or more instruments, wherein the transport instructions include instructions to transport the sample container through adjacent blocks. The sample container is transported to the one or more instruments in response to the transport instructions. Other methods and apparatus are disclosed.
In some embodiments, a method of classifying components of a blood sample is provided that includes digitally staining an image of a blood sample using a trained machine-learning model so as to generate a digitally-stained image; extracting one or more intermediate features generated by the trained machine-learning model during digital staining of the image; providing the one or more extracted intermediate features to a trained multi-class classifier; and employing the trained multi-class classifier to classify at least one component within the blood sample based on the one or more extracted intermediate features. Numerous other embodiments are provided.
Methods are disclosed for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,500. The method comprises the use of a first antibody that binds to the small molecule and a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a hapten that is not the small molecule or a derivative of the small molecule wherein the hapten comprises a moiety that is structurally similar to that of the second portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
A calibration method is provided including identifying the imaging area on each light panel with respect to each imaging device. A center position of the imaging area of each light panel for each imaging device is determined. An optimal optical center of the imaging apparatus using the center position of the imaging area of each imaging device is determined. A tube calibration tool is installed in a carrier on a track, and the carrier is moved on the track so that a center of the tube calibration tool is located at a closest location to the optimal optical center of the imaging apparatus. The center of the tube calibration tool is used to determine a center of a region of interest (ROI) for backlight calibration. Methods for heath checking the calibration and apparatus used to carry out the calibration are provided as well as other aspects.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
38.
DEVICE AND METHODS FOR ISOLATING MICROORGANISMS FROM BIOLOGICAL SAMPLES FOR DIAGNOSTIC ANALYSIS
A method of isolating microorganisms present in a biological sample for diagnostic analysis, such as a diagnostic assay for sepsis. The method involves the use of filtration and acoustophoresis to substantially lyse any blood cells present in the biological sample and isolate any microorganisms present in the biological sample from the lysed cellular debris. Also disclosed are microfluidic devices, kits, and systems that can be utilized in the method.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
39.
METHOD AND DEVICE FOR DETERMINING ONSET OF SEPSIS IN EMERGENCY SET-UPS
A method (200) and a device (100) for determining onset of sepsis are provided. In one aspect, the method (200) includes receiving a medical dataset associated with the patient. Further, the method (200) includes determining if the plurality of medical parameters includes at least one sepsis specific parameter. Additionally, the method (200) includes determining a first output parameter if the plurality of medical parameters does not include at least one sepsis specific parameter. The method (200) also includes determining a second output parameter indicative of onset of sepsis in the patient if the plurality of medical parameters include at least one sepsis specific parameter, wherein the medical parameters associated with the patient are obtained for at least one time instance.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
Chemiluminescent acridinium conjugates and compounds capable of forming conjugates are disclosed. These chemiluminescent acridinium conjugates may be used as chemiluminescent tracers in immunoassays for the quantification and identification of certain analytes.
Apparatus for robotic arm alignment in an automated sample analysis system includes a robotic arm, a sample tube carrier, a plurality of optical components (including, e.g., one or more cameras), and a controller. The controller is operative to process images received from the optical components to determine a first set of coordinates of a first marker relative to the sample tube carrier and determine a second set of coordinates of a second marker relative to the robotic arm. The controller is further operative to adjust the position of the robotic arm and/or the sample tube carrier in response to an excessive offset between the first and second sets of coordinates. In some embodiments, a positioning tool includes the first and second markers thereon. Methods of robotic arm alignment with a sample tube carrier in an automated sample analysis system are also provided, as are other aspects.
Methods of predicting a fault in a diagnostic laboratory system include providing one or more sensors; generating data using the one or more sensors; inputting the data into an artificial intelligence algorithm, the artificial intelligence algorithm configured to predict at least one fault in the diagnostic laboratory system in response to the data; and predicting at least one fault in the diagnostic laboratory system using the artificial intelligence algorithm. Other methods, systems, and apparatus are also disclosed.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
B01L 99/00 - Subject matter not provided for in other groups of this subclass
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
43.
METHOD FOR DETECTING TOTAL 25-HYDROXYVITAMIN D USING ANTIBODIES TO 25-HYDROXYVITAMIN D2 AND D3
Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25-hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.
33) sensor. Kits and systems containing the electrochemical sensor modules are also disclosed, as well as methods of using the electrochemical sensor modules.
The present disclosure includes certain steps in immunoassays, such as immunoassays based on chemiluminescence, which increase assay sensitivity as based on a variety of metrics including increasing signal to noise and decreasing limits of detection. One strategy for these enhancements involves movement, and potential sequestration, of solid phases in one triggering reagent prior to addition of a second triggering reagent for chemiluminescence..
A self-tuning optical bubble detector assembly for diagnostic analyzers. The bubble detector assembly has a light emitter operated at a plurality of inputs (i.e., generating a plurality of light intensities) for dry supply line tubing (i.e., having no liquid) and for a wet supply line tubing (i.e., having liquid therein). A plurality of outputs representing light detected through the dry supply line tubing and the wet supply line tubing are generated. Based on the received outputs, a final calibrated setting (e.g., a % duty setting or an I_LED) and a threshold are determined at which to accurately and repeatedly determine if the supply line tubing has liquid or air therein. Further provided are methods of self-tuning an optical bubble detector for diagnostic analyzers and computer program products, as are other aspects.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Diagnostic reagents and chemicals for clinical and medical use. Computer software for use with medical diagnostic instruments; computer hardware and computer software for use in operating medical diagnostic instruments for the analysis of body fluids and for use in analyzing the data generated by medical diagnostic instruments for the analysis of body fluids, sold as a unit. Medical diagnostic instruments.
48.
SYSTEMS AND METHODS FOR DETERMINING TEST RESULT ACCURACIES IN DIAGNOSTIC LABORABORY SYSTEMS
A method of determining the accuracy of a test performed by a diagnostic laboratory system includes obtaining one or more first measurements during a first operation of the test performed by the diagnostic laboratory system. One or more second measurements are obtained during a second operation of the test performed by the diagnostic laboratory system. The first measurements and the second measurements are collectively analyzed using a trained model that calculates an uncertainty score for the test based on learned correlations between the first operation and the second operation. The uncertainty score may be used to determine whether the test results can be relied upon or whether the test should be rerun. Other methods and systems are disclosed.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G06N 3/04 - Architecture, e.g. interconnection topology
G06N 5/00 - Computing arrangements using knowledge-based models
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
49.
DEVICES AND METHODS FOR TRAINING SAMPLE CONTAINER IDENTIFICATION NETWORKS IN DIAGNOSTIC LABORATORY SYSTEMS
A method of training a sample container identification network of a diagnostic laboratory system includes obtaining a plurality of data subsets, wherein each data subset is smaller than a full training data set used to train the sample container identification network and includes a plurality of images of one or more sample containers. The sample container identification network is trained on each of the plurality of data subsets to generate a plurality of trained sample container identification networks. Each of the trained sample container identification networks are testing using testing data that includes test images of sample containers, wherein the testing includes identifying the sample containers in the test images. A core data set is selected from one of the plurality of data subsets based on the testing, the core data set for use in training a deployed sample container identification network. Other methods and systems are disclosed.
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G06N 3/04 - Architecture, e.g. interconnection topology
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
G06V 10/84 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using probabilistic graphical models from image or video features, e.g. Markov models or Bayesian networks
50.
METHOD, DEVICE AND SYSTEM FOR ENHANCING IMAGE QUALITY
A method, device and system for enhancing image quality of an image is provided. In one aspect, the method includes illuminating a sample with a light source associated with an imaging device. Further, the method includes simulating a transmission wave at a sensor plane of the imaging device for a light wave from illuminating the sample. Additionally, the method includes determining a phase and amplitude information associated with the light wave based on the transmission wave. The method also includes determining at least one microscope transfer function associated with the imaging device based on the phase and amplitude information. Furthermore, the method includes generating a modified mi-croscope transfer function using a Zernike function based on the at least one microscope transfer function in an iterative procedure and enhancing the image quality associated with the im-age using the modified microscope transfer function.
Disclosed is a blood contamination detection apparatus. The blood contamination detection apparatus comprises a computer-based contamination determining module configured to receive: one or more baseline quantified test results on an uncontaminated blood sample obtained from a patient; one or more quantified test results for one or more analytes of a blood sample or a blood component; and data input on a type of IV fluid infusion that the patient has received that is able to affect the one or more quantified test results. The computer-based contamination determining module comprises a contamination determining routine executable on a computer and configured to compare differences between the one or more baseline quantified test results and the one or more quantified test results against preset threshold difference values and/or directions and provide a contamination output. Sample contamination detection method are provided, as are other aspects.
G01N 21/88 - Investigating the presence of flaws, defects or contamination
G01N 15/05 - Investigating sedimentation of particle suspensions in blood
G01N 1/00 - Sampling; Preparing specimens for investigation
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
A system and method of tracking vessel movers within a liquid handler system using sparse sensor assemblies. The method includes mapping received sensor signals to pre-characterized functions and determining the positions of the vessel movers with respect to a single sensor from the sensor assembly accordingly. The sensors in the sparse sensor assembly can be positioned to have no or minimal overlap between their sensing ranges.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
54.
HYBRIDIZED CONTROL ARCHITECTURE FOR VESSEL MOVER MOVEMENT CONTROL
A system and method for a hybridized control architecture for a liquid handler system. The hybridized control system can control the movement of the vessel movers of the liquid handler system using a hybridized movement control approach that incorporates both position, velocity and current-based control outputs. The control system can further dynamically control the relative degree to which velocity or position-based control is applied to the vessel movers based on the vessel movers' relative positions along the track system.
B65G 43/08 - Control devices operated by article or material being fed, conveyed, or discharged
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
55.
PIPETTE TIPS, PIPETTE ASSEMBLIES, ASPIRATION AND DISPENSE SYSTEMS, AND METHODS OF PREVENTING PIPETTE TIP STICTION
A pipette tip configured to aspirate and dispense liquids. The pipette has a tip comprising an opening, wherein the pipette has one or more blades having a length extending at least partway from the tip, and at least some of the one or more blades include an acute-angled cutting edge along the length. In some embodiments, the pipette tip is part of a detachable pipette tip having a tip body with a first end configured to detachably couple to a pipette. Other detachable pipette tips, pipette tips, pipette assemblies, aspiration and dispense systems, testing apparatus, and methods of accessing a well through a well cover are disclosed.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Methods and systems for detecting an obstruction on a sensor of a fluid analyzer, including a method comprising causing a first calibration fluid to contact the sensor to generate signals indicative of a first electric potential of the first calibration fluid; causing a second calibration fluid to contact the sensor to generate signals indicative of a second electric potential of the second calibration fluid; storing a first response slope; causing the first calibration fluid to contact the sensor to generate signals indicative of a third electric potential of the first calibration fluid; causing the second calibration fluid to contact the sensor to generate signals indicative of a fourth electric potential of the second calibration fluid; storing a second response slope; and storing data indicative of an obstruction on the sensor in response to a difference between the first response slope and the second response slope being beyond a threshold.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
57.
VIBRATING PIPETTE TIPS AND METHODS OF PREVENTING PIPETTE TIP STICTION
A pipette assembly configured to aspirate liquid from a well having a cover includes: a pipette including a terminal end; a pipette tip detachably coupled to the terminal end; and a vibration inducer configured to vibrate the pipette tip when at least a portion of the pipette tip is located in the well thus reducing stiction between the cover and the pipette tip. This minimizes the pipette tip from getting detached from the pipette and stuck in the cover. Other systems and methods including vibrating a pipette tip are disclosed.
A tray insert for use with an apparatus configured to analyze a sample is disclosed. The tray insert includes a first surface comprising an elongated channel adapted to receive a reagent strip for sample analysis. Further, the insert includes a second surface, wherein the second surface is in a direction opposite to the first surface. Additionally, the insert includes a hollow enclosure between the first surface and the second surface, wherein the elongated channel on the first surface comprises a plurality of slots and wherein the slots comprise an opening on each end, wherein the opening enters the hollow enclosure.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Reagents for research purposes; chemical reagents for non-medical purposes; kits composed primarily of reagents for in vitro scientific and research use Medical diagnostic reagents; diagnostic reagents for medical use; chemical and biological compounds used as standards or calibrators for clinical medical or medical laboratory uses for the purpose of maintaining and ensuring the accuracy of test results Medical diagnostic test kit comprising one or more diagnostic test assays and a diagnostic test calibrator for diagnostic identification of one or more biomarkers in humans.
60.
HIGH-SENSITIVITY CHEMILUMINESCENCE DETECTION SYSTEMS AND METHODS
A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.
Methods of identifying a defect in a machine vision system. Embodiments of the method include providing a first imaging device having a first field of view; moving a reflective tool through the first field of view; capturing a plurality of images of the reflective tool at different locations in the first field of view using the first imaging device; and analyzing at least one of the plurality of images to identify one or more defects in the machine vision system. Systems and apparatus configured to carry out the methods are provided, as are other aspects.
A method (100) of extracting nucleic acids is disclosed. The method includes receiving a sample containing nucleic acids to be extracted. The method (100) includes lysing cells in the sample to release the nucleic acids. The method (100) also includes introducing the released nucleic acids to a substrate, wherein the nucleic acids bind to the substrate. The method (100) includes washing the substrate bound to the nucleic acids and eluting the nucleic acids from the substrate. The introducing of the released nucleic acids to the substrate, the washing of the substrate bound to the nucleic acids, and the eluting of the nucleic acids are performed in a pipette tip.
Non-limiting embodiments of a system(s) of generating interfering flags to reduce false diagnosis due to interfering conditions present in urinalysis results, and method(s) related thereto.
Systems and methods for dynamic route planning for use with modular liquid handler systems. A route planning algorithm can be utilized to plan routes for the vessel movers of the liquid handler systems in a dynamic manner, without the need for hardcoded routes, so that a route planning system can efficiently transport samples between modules of the liquid handler systems while minimizing risks of collisions and jams. The route planning algorithm can be configured to receive a representation of the liquid handler system configuration and plan routes for the vessel movers accordingly.
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
G05B 15/02 - Systems controlled by a computer electric
Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.
A method of receiving an image of a test device through a transparent shield not associated with an imaging system, wherein the transparent shield is positioned within a housing of a reagent analyzer; comparing pixel data of the received image of the test device through the transparent shield to determine a degree of occlusion of the transparent shield; determining whether the degree of occlusion exceeds a baseline value indicative of potential occlusion; and responsive to the degree of occlusion exceeding the baseline value, causing an action selected from a group consisting of: initiating an alert in a form perceivable by a human; storing data indicative of the degree of occlusion detected within the image exceeding the baseline value; initiating a cleaning process configured to clean the transparent shield; and replacing the transparent shield with a replacement transparent shield having a degree of occlusion less than the baseline value.
Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G06F 16/31 - Indexing; Data structures therefor; Storage structures
G06F 16/36 - Creation of semantic tools, e.g. ontology or thesauri
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
68.
SCALABLE DEPLOYMENT OF ONTOLOGY-BASED DECISION TREES FOR CLINICAL DECISION SUPPORT AND AUTOMATED CLINICAL WORKFLOWS
Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
69.
DEVICES AND METHODS FOR TRAINING SAMPLE CHARACTERIZATION ALGORITHMS IN DIAGNOSTIC LABORATORY SYSTEMS
A method of updating training of an annotation generator of a diagnostic laboratory system includes providing an imaging device in the diagnostic laboratory system, wherein the imaging device is controllably movable within the diagnostic laboratory system; capturing a first image within the diagnostic laboratory system using the imaging device, the first image captured with at least one imaging condition; performing an annotation of the first image using the annotation generator to generate a first annotated image; and updating training of the annotation generator using the first annotated image. Other methods and systems are disclosed.
Methods of troubleshooting non-event malfunctions include providing a database including pre-populated non-event issues and associated corrective actions, receiving search criteria regarding a particular non-event issue via entry of a search string at a user interface, parsing and normalizing the search string into a meta-data schema to produce a normalized search string, searching the database with the normalized search string to generate a listing of one or more particular corrective actions, and receiving the listing of one or more particular corrective actions that are associated with the normalized search string. Apparatus configured to carry out the methods are provided, as are other aspects.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G06F 16/907 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually
Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and/or conjugates are also disclosed, along with microfluidics devices containing same.
C09B 62/12 - Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to a pyridazine ring
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Fluid analyzation devices, methods, and systems are disclosed including an analyzation device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an piezo transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the piezo transducer configured to emit ultrasonic acoustic waves having a first frequency, a second frequency, and a third frequency into and/or to a blood sample within the microchannel, the first frequency configured to begin separation of red blood cells and plasma in the blood sample, the second frequency configured to complete separation of the red blood cells and plasma, and the third frequency configured to rupture cell walls of the blood cells producing a lysed blood sample.
An acoustophoresis device having a sample vessel and a piezo transducer is described. The sample vessel has an outer surface, a microchannel within confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel, such that a blood sample is insertable through the first port into the microchannel. The sample vessel has conductive traces on the outer surface. The piezo transducer is bonded to the outer surface of the sample vessel to form a monolithic structure. The piezo transducer contacts at least one of the conductive traces, the piezo transducer is configured to generate ultrasonic waves inside a sample in the microchannel. The piezo transducer has an excitation signal input and response signal output electrically connected to the at least one of the conductive traces.
Chromatographic assay devices for detecting the presence of free hemoglobin in a liquid biological sample are disclosed. The device comprises a sample application pad and a chromatographic detection pad, wherein the sample application pad is formed of two layers of material. Medical diagnostics devices for use with the chromatographic assay devices are also disclosed, as well as kits and methods of using the chromatographic assay device and/or medical diagnostics device.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. hemoglobin, bilirubin
75.
SAMPLE COLLECTION APPARATUS AND METHODS FOR IMMUNOASSAY TESTING
A method of increasing a concentration of an antigen of a respiratory virus is provided. The method includes preparing a sample containing a first concentration of the antigen; contacting the sample containing the first concentration of the antigen to a first material having a negatively-charged surface, thereby capturing an amount of the antigen with the first material; contacting a second material to the first material to transfer the antigen from the first material to the second material, the second material having an ionic strength sufficient to release the captured antigen from the first material into the second material; and obtaining a resulting solution containing the antigen in a second concentration. The second concentration of the antigen in the resulting solution is higher than the first concentration of the antigen in the sample. Numerous other aspects in accordance with this and other embodiments are provided.
The present disclosure relates to a method of determining antibiotic susceptibility of a micro-organism in a sample, the method including: receiving the sample containing the micro-organisms; incubating at least one first portion of the sample with at least one antibiotic and at least one second portion of the sample with no antibiotic; extracting nucleic acid from the at least one first portion of the sample and the at least one second portion of the sample, wherein the nucleic acid is associated with the micro-organisms present in the sample; amplifying the extracted nucleic acid from the at least one first portion and the at least one second portion of the sample; and obtaining the antibiotic susceptibility information associated with the micro-organism from the amplified nucleic acid from the at least one first portion and the at least one second portion of the sample.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 1/00 - Sampling; Preparing specimens for investigation
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
A microfluidic device has a first substrate, a resilient diaphragm, an actuator, and a second substrate. The first substrate has an opening extending therethrough. The resilient diaphragm is secured to a second side and surrounds the opening. The actuator is secured to a first side and surrounds the opening. The first substrate, the resilient diaphragm, and the actuator cooperate to form a gas-tight chamber. The second substrate has a channel formed therein having a first end and a second end. The second substrate is secured to the first substrate. A volume of gas disposed in the gas-tight chamber pressurizes the gas-tight chamber and expands the resilient diaphragm such that the resilient diaphragm is disposed in the channel between the first end and the second end. The resilient diaphragm retracts from the channel to open the channel from the first end and the second when the gas-tight chamber is depressurized.
In some embodiments, a method of determining a viewpoint for optically inspecting a sample within a sample container is provided that includes ( a ) employing a sensor to capture image data of a sample container including a sample, wherein a portion of the sample container includes a label having first and second ends; (b) rotating at lea st one of the sample container and the sensor about a central axis of the sample container so that the sensor capture s image data including at least the first and second ends of the label; ( c ) employing the captured image data to generate an unwrapped image of the sample container; (d) processing the unwrapped image to characterize the label and produce label characterization information; and ( e ) employing the label characterization information to identify a viewpoint through which to optically inspect the sample within the sample container. Numerous other aspects are provided.
H04N 19/167 - Position within a video image, e.g. region of interest [ROI]
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
79.
SYSTEM, METHOD AND POINT OF CARE DEVICE FOR IMAGE ANALYSIS OF DIAGNOSTIC ASSAYS
An image analysis system, a method and a point of care device are provided for determining, from an image of a cassette containing a sample, a concentration of one or more target analytes in the sample. The method includes identifying a region of interest (ROI) from the image corresponding to a result viewing area of the cassette, generating a unidimensional (1D) profile of the ROI, and probabilistically determining from the 1D profile, the concentration of the target analyte(s) in the sample based on a statistical model having one or more parameters of the 1D profile varying with respect to time and/or the concentration of the target analyte(s) in the sample.
A sample handler of a diagnostic laboratory system includes a plurality of holding locations configured to receive sample containers. An imaging device is movable within the sample handler and is configured to capture images of the holding locations and sample containers received therein. A controller is configured to generate instructions that cause the imaging device to move within the sample handler and capture images. A classification algorithm is implemented in computer code, and includes a trained model configured to classify objects in the captured images. Other sample handlers and methods of handling sample containers are disclosed.
G01N 1/00 - Sampling; Preparing specimens for investigation
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups.
Methods of troubleshooting non-event malfunctions. The methods include providing a database including pre-populated non-event issues and associated corrective actions, inputting search criteria regarding a particular non-event issue via entry of a search string at the user interface, parsing and normalizing the search string into a meta-data schema to produce a normalized search string, searching the database with the normalized search string to generate a listing of one or more particular corrective actions, and receiving the listing of one or more particular corrective actions that are associated with the normalized search string. Apparatus configured to carry out the methods are provided, as are other aspects.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A diagnostic laboratory system includes one or more instruments and a transport system configured to transport sample containers to and from the one or more instruments, wherein each of the sample containers contains a biological sample. A computer is configured to execute a program to control operation of the diagnostic laboratory system. The program has an architecture comprising a plurality of individually replaceable software modules, wherein one or more software modules identify at least one test or plan at least one phase thereof to be performed on the biological sample. Another software module generates instructions to cause one or more of the sample containers to move to or from the one or more instruments in accordance with the at least one test or the at least one phase thereof. Methods of operating a diagnostic laboratory system are also disclosed.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
B65G 47/52 - Devices for transferring articles or materials between conveyors, i.e. discharging or feeding devices
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A docking assembly for a point-of-care analyzer. The docking assembly comprises an adapter and interface clip. Adapter includes an adapter body attachable to the point-of-care analyzer, the adapter body having an opening and adapter electrical connector. The interface clip is receivable in the opening and includes a clip body and clip electrical connector. Clip electrical connector includes a clip interface member electrically interfaceable with a data and power port of a handheld computing device, and a clip data and power member configured to electrically connect with an adapter interface member. The adapter electrical connector and the clip electrical connector are configured to facilitate charging of the handheld computing device through an electrical connection between at least one adapter charging contact and the clip interface member. Adapters, interface clips, point-of-care assemblies using the docking assemblies, and methods of operating such point-of-care assemblies are provided, as are other aspects.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 33/483 - Physical analysis of biological material
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing an authentication code. The authentication code has a lot value and a secondary value related to the lot value by a predetermined function assigned to the lot value.
A method for determining an amount of alkylphenol ethoxylate compounds in an aqueous sample is provided. The aqueous sample is subjected to an extraction technique to produce a purified sample, the purified sample is subjected to a chemical cleavage technique to convert alkylphenol ethoxylate compounds in the purified sample to their corresponding alkylphenol compounds and produce a cleaved sample. The cleaved sample is subjected to a liquid chromatography technique to obtain a fraction enriched in alkylphenol compounds from the cleaved sample. The fraction enriched in alkylphenol compounds is ionized under conditions suitable to generate fragment ions detectable by mass spectrometry. The amount of the fragment ions is determined using mass spectrometry, and the amount of the fragment ions is related to the amount of alkylphenol ethoxylate compounds in the aqueous sample.
Methods for determining the presence, severity, and/or predisposition of Idiopathic Pulmonary Fibrosis (IPF) in an individual are disclosed. The methods utilize at least one diagnostic marker of a dynamic process of extracellular matrix synthesis and/or extracellular matrix degradation from said sample. The at least one diagnostic marker may be selected from the group consisting of tissue metallopeptidase inhibitor 1 (TIMP1), hyaluronan (HA), and/or Procollagen Type III N-terminal propeptide (PIIINP).
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A sensor array is disclosed. The sensor array includes a fluid inlet, a fluid outlet, a flow path extending between the fluid inlet and the fluid outlet; and at least one optimization sensor positioned outside of the flow path of the sensor array and configured to provide at least one performance parameter of the sensor array. The at least one performance parameter having performance data of the sensor array.
Lateral flow assay devices and kits for use in the detection of creatinine and in the detection of hemolysis in a biological fluid sample are disclosed. Methods of making and using the lateral flow assay devices and kits are also disclosed.
Embodiments provide a fitting for tubing connection, a male fitting assembly, and a torque adaptor. The fitting for tubing connection includes a head including a plurality of first gripping portions, each first gripping portion extending from a top of the head; and a shaft attached to the head, wherein the shaft comprises a plurality of external threads.
F16L 19/025 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member the pipe ends having integral collars or flanges
F16L 19/02 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member
B25B 13/50 - Spanners; Wrenches for special purposes for operating on work of special profile, e.g. pipes
91.
COMPUTATIONALLY-EFFICIENT LOAD PLANNING SYSTEMS AND METHODS OF DIAGNOSTIC LABORATORIES
Systems and methods include an optimization-based load planning module including a data-reduction scheme for analyzers of bio-fluid samples. The optimization-based load planning module is executable on a computer server and is configured to optimize assay type assignments across a large number of analyzers based on one or more objectives, such as: load balancing, efficient reagent usage, reduced turn-around-time, reduced quality assurance costs, and/ or improved system robustness. The optimization-based load planning module uses a data-reduction scheme to generate a load plan comprising computer-executable instructions configured to cause a system controller of a diagnostic laboratory system to assign each of the requested test types to be performed over the planning period to one or more selected analyzers in accordance with the one or more preferences or priorities. Other aspects are also described.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A reagent analyzer comprising an imaging system having a first field of view of a reagent test device and a second field of view of a fluid sample information indicator, and configured to capture a first image depicting the reagent test device and a second image depicting the information indicator; a mirror moveable between a first position outside the first field of view and a second position inside the first field of view and located between the imaging system and the reagent test device, the mirror in the second position reflecting light to produce the second field of view; and a processor executing instructions to: receive the first and second images; analyze the first image to determine calibration information from the information indicator; and analyze the second image to determine constituent presence/absence in the fluid sample applied to the reagent test device, using, in part, the determined calibration information.
A reagent analyzer having a circuit board, an imaging system and a processor is disclosed. The circuit board has a substrate, and a plurality of conductive leads. The substrate has a first and a second major surface. The first major surface is opposite the second major surface. The substrate has an opening extending between the first major surface and the second major surface. The reagent analyzer also includes an imaging system having a field of view extending through the opening formed in the substrate and configured to capture an image of a wet reagent test device positioned at a read position in the field of view, the image having a plurality of pixels. The processor is configured to receive the image, and to analyze pixels of the image to determine a presence or an absence of a target constituent being in a sample applied to the wet reagent pad.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
F21V 19/00 - Fastening of light sources or lamp holders
H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
H04N 23/56 - Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
G06T 7/90 - Determination of colour characteristics
Methods of visualizing sample status within a diagnostic laboratory system are provided. The methods include displaying on a display screen, a visual image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and further to display on the visual image, for a particular selected sample scheduled for testing, status indicators located proximate to the visual images of the analyzers on which the tests are scheduled. The status indicators denote: the testing is completed on one or more analyzers (processed), the testing is currently being conducted on one or more analyzers (current), or the testing has not yet been received on the one or more analyzers (to do). Systems including such sample status indicators are provided as are other aspects.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
Methods of controlling diagnostic laboratory systems include providing one or more modules, each of the one or more modules configured to process a specimen container and/or analyze a specimen; providing middleware configured to communicate with the one or more modules, wherein the middleware is configured to generate instructions to change an operational state of at least one of the one or more modules to enabled or disabled; generating, by the middleware, one or more instructions to change the operational state of at least one of the one or more modules; and changing the operational state of at least one of the one or more modules in response to one or more instructions generated by the middleware. Systems including a middleware server configured to carry out the methods are provided as are other aspects.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G05B 15/02 - Systems controlled by a computer electric
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
96.
VORTEX GENERATOR FOR AGITATION OF FLUIDS DURING SAMPLE PREPARATION
An apparatus, vortex generator assembly and method for automated cell lysis and nucleic acid purification and processing. The vortex generator assembly includes sample holder having a lysis well, at least one wash well, and an elution well. The vortex generator assembly also includes a sample holder cover having a plurality of vibration rods for creating a vortex in the wells of the sample holder. The apparatus includes motor operating a rotating cam to cause the vibration rods to vibrate and create the vortex in a well holding fluid and magnetic beads, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and disperse the beads in solution, to collect nucleic acids such as DNA.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
B01F 33/452 - Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
B01F 33/81 - Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
B01F 31/44 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
B01F 31/441 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
An automated diagnostic analysis system includes a plurality of modules for processing and analyzing biological samples, a sample transport system for transporting sample containers to and from each of the modules, and a system controller for workflow planning and execution of sample analyses. To increase functionality of the automated diagnostic analysis system without increasing the floor space of the system, one or more of the modules may be configured to receive one or more functional units each operative to perform an additional action in connection with the sample analyses. The functional unit does not require separate access to the sample transport system, and the system controller is configured to dynamically include the functional unit in the workflow planning and execution of the sample analyses. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.
Systems and methods for passively redirecting liquid contaminants from the active region of riding surfaces of track systems for liquid handler systems, including surface energy gradient, channels, and roughness gradients. The described techniques redirect liquids in a passive manner, without requiring any additional electromechanical components or active control systems that would draw additional power and require additional layers of control architecture to manage.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
B65G 54/02 - Non-mechanical conveyors not otherwise provided for electrostatic, electric, or magnetic
G01N 21/13 - Moving of cuvettes or solid samples to or from the investigating station
99.
ABSORBANCE SPECTROSCOPY ANALYZER AND METHOD OF USE
Absorbance spectroscopy methods and systems are disclosed including a spectroscopy analyzer, comprising: an optical element device positioned to receive an analysis light that passes through a sample of a fluid specimen from an illumination unit, the analysis light including first light in a first light range and second light in a second light range different than the first light range, the optical element device comprising: a housing assembly that defines an internal space; and a dichroic mirror-reflector within the internal space positioned to receive the analysis light, the dichroic mirror-reflector configured to filter the analysis light such that a first portion of the analysis light in the first light range is reflected off the dichroic mirror-reflector as a spectrometer light, and such that a second portion of the analysis light in the second light range passes through the dichroic mirror-reflector as a detector light.
The invention relates to a calibration target (1) for a Fourier ptychographic imaging system (100), comprising at least a first plane (2) and a second plane (4), wherein the first plane (2) and the second plane (4) are parallel to each other and comprise a predefined distance (d, 2a) between each other, wherein the first plane (2) comprises a first calibration structure (22) and the second plane (4) comprises a second calibration structure (24), wherein the first calibration structure (22) is configured to be suitable for centering itself in relation to an optical component (14) and/or a ccaammeerraa (12) of the Fourier ptychographic imaging system (100), and wherein the second calibration structure (24) is configured to be suitable for determining, directly or in projection onto the first plane (2), a position of at least one characteristic or predetermined feature of the first calibration structure (22).
