The present disclosure refers to a homogeneous method, apparatus and device for detection of target nucleic acids in a sample. In one aspect, the device includes a magnetic bead. Further, the device includes one or more oligonucleotides bound to the magnetic bead. Additionally, the device includes at least one reporter molecule linked to the one or more oligonucleotides.
Diagnostic immunoassay reagent compositions are disclosed that include liposomes having analyte-specific binding element(s) associated therewith. In particular, the analyte-specific binding element(s) includes a transmembrane domain that anchors the element(s) in the lipid bilayer of the liposome; the analyte-specific binding element(s) further includes an extracellular/extramembrane domain that is exposed on the outer surface of the liposome and that comprises a domain that specifically binds to the target analyte. Also disclosed are kits, devices, and systems that contain the diagnostic immunoassay reagent compositions, as well as methods of producing and using the diagnostic immunoassay reagent compositions.
An automated diagnostic analysis system includes a system controller for system-wide workflow planning and execution of sample analyses and also includes decentralized processing capabilities (e.g., one or more second controllers) for determining a work-around, where possible, to a detected fault affecting an analysis of a particular sample. The system controller communicates with system components via a first communication channel, while the second controller communicates with a subset of the system components via a second communication channel. Where a work-around for a detected fault cannot be determined by the second controller, the detected fault is communicated to the system controller for resolution. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
4.
DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF UPDATING
Diagnostic laboratory systems, methods of operating diagnostic laboratory systems, and methods of updating diagnostic laboratory systems are disclosed. A method of operating a diagnostic laboratory system includes identifying data in the system as identified data; identifying change in a data distribution of the identified data; aggregating data instances pertaining to the change in the data distribution; selecting a subset of the aggregated data to update a processing algorithm in the system; and updating the processing algorithm using the subset of the aggregated data. Other systems and methods are disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
5.
DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF IMAGING TUBE ASSEMBLIES
A method of synthesizing an image of a tube assembly includes capturing an image of the tube assembly, wherein the capturing generates a captured image. The captured image is decomposed into a plurality of features in latent space using a trained image decomposition model. One or more of the features in the latent space is manipulated into one or more manipulated features. A synthesized tube assembly image is generated with at least one of the manipulated features using a trained image composition model. Other methods and systems are disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A method of detecting a level of a liquid in a well of a container. The method includes looking up an expected liquid level of the liquid in the well of a container; measuring and recording a measured liquid level of the liquid in the well; changing a level of the liquid in the well based upon an expected amount of the liquid to be added or removed; and calculating a next expected liquid level at least in part based on multi-point filtering. Apparatus for carrying out the method are provided, as are other aspects.
An apparatus, a method and a device for calibrating the apparatus is disclosed. The apparatus comprises one or more light sources, at least one image acquisition device for acquiring images; and a device. The device comprises a processing unit, a memory coupled to the processing unit. The memory comprising a calibration module configured to obtain a value of current flowing through each of one or more light sources in real-time, compare the value of current flowing through each of the one or more light sources with a predefined threshold current value, and calibrate color gain value associated with at least one image acquisition device, if the determined value of current for each of the one or more light sources is above the predefined threshold current value.
A system (100) and a method (200) for predicting presence of a disease in a subject is disclosed. In one aspect, the system (100) includes one or more processing units (101), a medical database (112) coupled to the one or more processing units (101), and a disease prediction module (110). The module (110) is configured to receive a plurality of parameters associated with the subject. Additionally, the module (110) is configured to determine a threshold for sensitivity and/or specificity associated with a trained machine learning model. Further, the module (110) is configured to predict using the trained machine learning model the presence of the disease in the subject based on the desired sensitivity and specificity and the plurality of parameters associated with the subject and output the prediction on an output unit (105).
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
Goods & Services
Computer software for use with clinical diagnostic
instruments used to analyze and interpret data and generate
reports; communications software for connecting laboratories
to a proprietary computer network providing proprietary
laboratory test data; communications software for providing
medical diagnostic information; computer hardware for
medical diagnostic testing in the field of immunoassays. Diagnostic systems used to generate diagnostic test results
and to measure and test blood and other biological samples,
comprised of analyzers for medical diagnostic testing in the
field of immunoassays; medical and clinical diagnostic
analyzers and instruments for use in testing biological
samples for testing in the field of human in-vitro
diagnostics for clinical purposes; medical apparatus for
clinical and medical diagnostic use, namely, sample
processing and analysis of information related thereto for
testing in the field of human in-vitro diagnostics for
clinical purposes. Providing on-line courses in the field of medical laboratory
testing, equipment software usage and laboratory management;
educational and training services, namely, courses in the
field of medical laboratory testing, equipment, software
usage and laboratory management.
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software for use with clinical diagnostic
instruments used to analyze and interpret data and generate
reports; communications software for connecting laboratories
to a proprietary computer network providing proprietary
laboratory test data; communications software for providing
medical diagnostic information. Compilation of information into computer databases through
the Internet relating to the conducting transactions for
business purposes, namely, for material ordering and
shipping, inventory management and maintenance, and for
generation of related business reports for clinical and
medical laboratories; business management services. Scientific technological and research services in the field
of human in-vitro diagnostics for clinical purposes in the
field of laboratory testing; providing technical information
in the field of laboratory testing; providing technical
information regarding clinical laboratory instrument usage
and efficiency accessible via a computer database. Medical analysis services for diagnostic and treatment
purposes provided by medical laboratories of persons in the
field of human in-vitro diagnostics; clinical medical
services, namely, technical consultation in the field of
medical testing for diagnostic or treatment purposes.
11.
ESTIMATING PATIENT RISK OF CYTOKINE STORM USING BIOMARKERS
Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A vector representing a state of the patient is generated based on the input medical data. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A method of patient-centric load planning for a diagnostic laboratory having a plurality of instruments includes receiving a list of patient samples, a list of requested tests to be performed for each of the patient samples, and patient-centric information for the patient providing each patient sample. The received data is used to determine a load plan for the instruments, the load plan including a menu of selected tests assigned to each instrument and an ordering of patient samples according to a priority score based on at least a portion of the electronic health record (EHR) of the patient providing the patient sample. A system for patient-centric load planning includes a plurality of instruments controlled by a system controller and computer server to formulate and execute the load plan.
G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
G06Q 10/0637 - Strategic management or analysis, e.g. setting a goal or target of an organisation; Planning actions based on goals; Analysis or evaluation of effectiveness of goals
13.
ESTIMATING PATIENT RISK OF CYTOKINE STORM USING KNOWLEDGE GRAPHS
Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A knowledge graph is computed based on the input medical data. A vector representing a state of the patient is generated based on the knowledge graph. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
14.
SEALING SYSTEM BETWEEN A MANIFOLD AND A LIQUID CONTAINER
A sealing system is provided that includes a liquid container configured to hold a liquid. The liquid container defines an opening having an inner circumferential sealing surface surrounding the opening, a manifold through which liquid is supplied to and/or removed from the liquid container. The manifold includes a sealing protrusion having an outer circumferential sealing surface, which is curved along a longitudinal axis. In a connected state, the manifold is located on the opening to supply liquid to, or to remove liquid from, the liquid container. The sealing protrusion extends into the opening, and the outer circumferential sealing surface contacts the inner circumferential sealing surface to form a seal between the manifold and the liquid container. In an unconnected state, a circumferential length of the outer circumferential sealing surface is larger than a circumferential length of the inner circumferential sealing surface.
A tiltable display screen assembly of a diagnostic analyzer. The tiltable display screen assembly includes a tiltable support interconnectable to a hand-held device including a display screen, a multi-angle adjuster having adjustment features, and a tilting screen mechanism pivotable relative to the tiltable support. The tilting screen mechanism includes a shaft, one or more moveable paddles coupled to the shaft, an adjustment member depending from the shaft configured to engage with the adjustment features of the multi-angle adjuster in order to adjust a tilt angle of the tiltable support and the display screen of the hand-held device. Diagnostic analyzers including the tiltable display screen assembly and methods for adjusting tilt angle of a display screen of a diagnostic analyzer are described, as are other aspects.
F16M 13/00 - Other supports for positioning apparatus or articles; Means for steadying hand-held apparatus or articles
E04G 3/00 - Scaffolds essentially supported by building constructions, e.g. adjustable in height
F16M 11/14 - Means for attachment of apparatus; Means allowing adjustment of the apparatus relatively to the stand allowing pivoting in more than one direction with ball-joint
16.
Portion of a display screen with a graphical user interface having a progress indicator
An assembly for use in a medical diagnostic device and system for analysis of one or more samples is disclosed. In one aspect of the invention, the assembly includes at least one extendable sample tray configured to hold the one or more samples. Additionally, the assembly includes at lease one holding unit coupled to the at least one extendable sample tray, wherein the holding unit is configured to hold a calibration marker. Furthermore, the extendable sample tray and the holding unit are arranged in the same plane and when the extendable sample tray is extended, the at least one holding unit is brought in a field of view of an image capturing unit.
A reagent strip and a reagent analyzer for reading the reagent strip is described. The reagent strip includes a substrate, at least one reagent pad positioned on the substrate, and a photo luminescent phosphor spot positioned at a fixed location on the substrate. The photo luminescent phosphor spot is formulated to exhibit a predetermined addressable attribute.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
21.
DEVICES AND METHODS FOR PLASMA SEPARATION AND METERING
Devices, assemblies, and kits are disclosed for separating and/or metering a plasma sample from a patient's liquid test sample. Also disclosed are methods of producing and using same.
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
G01N 33/547 - Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
Analyzers and methods of use are disclosed, including a blood analyzer comprising a light source to transmit an optical signal; a detector to generate data indicative of optical signal intensity; a transparent sample vessel between the light source and the detector; a dispensing device to pass a first portion of the blood sample comprising whole blood or lysed blood into the vessel at a first instance of time, and to pass a plasma portion of the blood sample into the vessel at a second instance of time; a controller to cause a processor to obtain first and second data generated by the detector, the first data indicative of the optical signal passing through the first portion of the blood sample and the second data indicative of the optical signal passing through the plasma, to determine a total absorbance spectrum in which the first data is adjusted by the second data.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Non-limiting embodiments of a methodology of validating accuracy and precision determinations of a new urine sediment analyzer, and method(s) related thereto.
A method and biological sample analyzer is described that adjusts airflow within a housing based upon altitude. A first volume of air is moved by at least one fan within a housing of a biological sample analyzer. A temperature of the first volume of air is measured within the biological sample analyzer with a temperature sensor within the housing of the biological sample. Power output of at least one heater positioned within the housing of the biological sample analyzer is measured. The measured power output of the at least one heater is analyzed at the measured temperature within the biological sample analyzer. And, the fan is adjusted to move a second volume of air different from the first volume of air by comparing the measured power output of the at least one heater and expected power output of the at least one heater.
A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
27.
AUTOMATIC LIQUID ANALYTICAL REAGENT DISPENSING APPARATUS, ANALYTICAL ASSAY REACTION CARTRIDGES AND KITS, AND METHODS OF USE RELATED THERETO
Analytical assay reaction cartridges are disclosed that include a reagent tray containing a liquid reagent disposed therein and a flexible cover removably attached thereto. The flexible cover has a portion that extends beyond the reagent tray and that forms a tab portion extends through an opening in a lid member of the cartridge in order to facilitate removal of at least a portion of the cover and release of the liquid reagent. Also disclosed are analytical assay reaction kits that include the cartridges and diagnostic instruments for use with the analytical assay reaction cartridges/kits, as well as methods of making and using the cartridges/kits.
A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.
A wash station for use in a clinical analyzer of an in vitro diagnostics (IVD) environment for cleaning a probe comprises a basin, a vertically-elongated conduit, an inlet port, and a helix insert. The vertically-elongated conduit is attached to the interior of the basin. The inlet port is connected to a bottom portion of the basin. The inlet port is sized to receive and secure a wash feed line that propels a wash fluid upward through the vertically-elongated conduit. The helix insert is positioned within the vertically-elongated conduit and sized to allow insertion of the probe through a center portion of the helix insert for cleaning. The helix insert causes the wash fluid to flow in a helical shape around the probe as it is transported through the vertically-elongated conduit, thereby cleaning the probe.
Methods for determining if a patient is positive for COVID-19 infection are provided, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 total immunoglobulin antibodies (tAb) and anti-SARS-CoV-2 IgG antibodies in a patient sample. The two results are combined to provide optimal sensitivity and specificity for the COVID-19 assay. Also disclosed are kits and microfluidic devices for use in the methods.
A sensor assembly for a bodily fluid analyzer includes a reference electrode container containing a reference electrode, a membrane capable or configured to be in fluid communication with the reference electrode container; and a wicking member capable or configured to be in fluid communication with the reference electrode container. The wicking member is configured to draw a reference fluid contained in the reference electrode container towards the membrane when the membrane and the wicking member are exposed to the reference fluid.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
Kits, microfluidics devices, and methods are disclosed for determining if a patient is positive for COVID-19 infection, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 antibodies in a patient sample. The kits, microfluidics devices, and methods incorporate the use of a reflex test within the reagent cartridge for the major anti-SARS-CoV-2 antibody assay, wherein the minor assay of the reflex test is employed when the result obtained in the major assay is above a baseline index. The reflex test (i.e., minor assay) utilizes at least one reagent that is different from the reagents utilized in the major assay.
Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.
Embodiments provide a fluid metering device, including: a first fluid supply port for receiving a first fluid; a first fluid dispense port for dispensing the first fluid; a second fluid supply port for receiving a second fluid; a second fluid dispense port for dispensing the second fluid; a waste discharge port for discharging a mixture of the first fluid and the second fluid; a valve assembly including a plurality of valves; a manifold connected to the metering pump, wherein the manifold includes a plurality of fluid channels, and the manifold is used for communicating between the valve assembly and each port; a first tube connected between the second valve and the third valve for accommodating the mixture or the first fluid; and a second tube connected between the third valve and the fourth valve for accommodating the second fluid.
G01F 15/00 - MEASURING VOLUME, VOLUME FLOW, MASS FLOW, OR LIQUID LEVEL; METERING BY VOLUME - Details of, or accessories for, apparatus of groups insofar as such details or appliances are not adapted to particular types of such apparatus
G01F 15/18 - Supports or connecting means for meters
G01F 11/12 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
36.
QUANTITATION OF FUNCTIONAL GROUPS ON SOLID SUPPORTS
Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.
A computer implemented method, an imaging device, an image reconstruction system and a computer program product, for calibrating system parameters of the image reconstruction system are provided, and include obtaining low resolution captured images by illuminating a sample with light source(s), obtaining a high resolution representation of the captured images based on the system parameters and the captured images, generating an approximate function based on the high resolution representation and the captured images, wherein the approximate function is a function of system parameters, and generating an updated set of system parameters by optimizing the approximate function. The computer implemented method, the imaging device, the image reconstruction system, and the computer program product enhance speed of calibration of the image reconstruction system by orders of magnitude, thereby, enabling noise and artifact free microscopic imaging in a robust way for the lifetime of the microscope.
Biotin-trap compositions are disclosed that contain particles having an inner polymer coating layer disposed on at least a portion of an outer surface thereof and a biotin-specific binding partner conjugated to the inner polymer coating layer. The biotin-trap compositions may further include an outer polymer coating layer disposed about the biotin-specific binding partner. The biotin-trap compositions specifically bind to free biotin but do not substantially bind to biotin conjugated to other moieties, such as biotinylated assay reagents. Also disclosed are kits and microfluidics devices that include the biotin-trap compositions, as well as methods of producing and using the biotin-trap compositions.
A biological sample preparation and reverse crosslink treatment reagent is disclosed in which all molecular pre-analytical and sample preparation steps can be performed on the biological sample in the single reagent. Also disclosed are kits containing the treatment reagent and methods of producing and using the treatment reagent.
Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
Calibration and/or quality control reagents are disclosed for use in serology immunoassays for antibodies to a microorganism. In the reagents, antibodies specific to an antigen of the microorganism are complexed with anti-human Ig antibody to form a complex. Kits and microfluidics devices containing the reagents are also disclosed, along with methods of producing and using the reagents.
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
Disclosed herein are immunoassay methods and reagents for detecting anti-Zika IgM antibody in a biological sample from a subject and/or diagnosing Zika virus infection in a subject. Also disclosed are algorithms for implementing the disclosed methods. The disclosed immunoassay methods, reagents, and algorithms enable efficient and reliable qualitative detection of anti-Zika virus antibodies and rapid determination of presumptive positive results for Zika virus infection in human subjects.
Reagents, kits, and microfluidics devices are disclosed for detecting the presence and/or concentration of antibodies directed to microorganisms in human biological samples. Also disclosed are methods of production and use of the reagents, kits, and microfluidics devices. Anti-human immunoglobulin antibodies are utilized to enhance the signal produced by the assay.
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/544 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
A clinical diagnostics system provides at least one biochemical analyzer and a track with one or more carriers for clinical samples, wherein the track and carriers are configured to effect carrier motion in a horizontal plane and the biochemical analyzer is arranged above the track and the one or more carriers.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
48.
ELECTROMAGNETIC PCB CROSSROADS TOPOLOGIES FOR AUTOMATION TRACK SYSTEMS
A vessel transport system in a liquid handler system includes vessel movers that transport a sample vessel using a magnetic base. A track provides a selective magnetic field to propel the magnetic base of each vessel mover along the track using a plurality of multilayer printed circuit boards (PCB) arranged along a transport path. Each PCB has a plurality of multi-layer conductive coils within layers of the PCB and each coil has a plurality of single-layer spirals electrically coupled with one another to form a multilayer coil. A processor is configured to control selective application of currents to the plurality of multi-layer coils to create the selective magnetic field. At least a subset of the multi-layer conductive coils are stacked relative to one another below a surface of the track, such that the selective application of currents selects one of a plurality of branching paths along the track.
Compositions, devices, kits, and methods for calibrating at least one oxygen sensor in a blood gas, electrolyte, and/or metabolite instrument utilizing a calibration fluid comprising a pyrogallol oxygen scavenger.
A transport track for selectively routing magnetic vessel movers includes a plurality of multilayer printed circuit boards (PCB) arranged adjacent to one another such that a surface of each PCB provides a track surface along which the magnetic vessel movers ride. A plurality of conductive coils are formed within one of the PCBs and include a plurality of single-layer spirals electrically coupled in a stack with one another to form a multilayer coil. A processor is configured to control selective application of currents to the plurality of multi-layer coils to create a magnetic field to propel the magnetic vessel movers along the track. The plurality of conductive coils are arranged adjacent to one another in each PCB to create at least one continuous path for the magnetic vessel movers to move along.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
H02K 1/12 - Stationary parts of the magnetic circuit
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A sample insertion apparatus enabling a sample to be inserted into a diagnostic analyzer in a hands-free manner. The sample insertion apparatus includes an insertion head having a coupler configured to couple to a sample container having an insertion member, an arm containing a sample probe positioned stationary relative to the arm, and a retraction assembly coupled to the insertion head and configured to cause the sample container to move towards the sample probe to insert the sample probe into the insertion member. Sample insertion and operating methods for hands-free insertion of a sample into a diagnostic analyzer are described, as are other aspects.
A sample transport system has a carrier configured to hold a sample tube for a sample to be transported and mixed, a transporter configured to support the carrier, a guide portion configured to impart motion to the carrier on the transporter and deliver the carrier to a destination location, and a controller. The controller is configured to identify instructions associated with the sample, the instructions including a movement profile configured to cause mixing of the sample, communicate with the guide portion to cause the carrier to follow the movement profile on the transporter to cause the mixing of the sample, and deliver the sample to the destination location.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
A fluidic tubing assembly and method for a blood analyzer comprising a base, a first tube, and a second tube. The base is connectable to the blood analyzer and has a front side, a rear side, a first side, a second side, a top side, and a bottom side. A first connector is supported by the first side. The first end of the first tube is connected to the first connector. A second connector is supported by the top side. The second end of the first tube is connected to the second connector. A third connector is supported by the top side. The first end of the second tube is connected to the third connector. A fourth connector is supported by the bottom side. The second end of the second tube is connected to the fourth connector.
A random access automated molecular testing system and method is used with a planar polymerase chain reaction (PCR) chip to provide molecular detection covering a wide variety of assays/tests in a small footprint. An automated transport mechanism moves the PCR chip between a pipette loading station, a sealing station and an amplification and detection module to provide batchless and random-access amplification and detection of a biological sample fluid. The PCR chip a planar rectangular body, a U-shaped channel for receiving sample fluid from an inlet port and a gripping feature laterally extending from an upper surface of the body above the inlet port for use by the automated transport mechanism. An amplification and detection module includes a heating block, a clip with a viewing window for retaining the PCR chip and a detection platform for identifying a content characteristic of interest of the sample fluid.
A transport medium is disclosed that can be utilized for both sample collection and molecular diagnostic applications. The transport medium can be utilized with multiple types of biological samples and maintains the stability of nucleic acid present in the biological samples so that one or more nucleic acid assay target(s) present in the biological sample is not substantially degraded during storage and shipping. Also disclosed are kits containing the transport medium, mixtures that include a biological sample disposed in the transport medium, and methods of producing and using the medium.
Immunoassay reagents are disclosed that contain a dehydroepiandrosterone sulphate-fluorescein (DHEAS-FITC) conjugate or a dehydroepiandrosterone sulphate-carboxymethoxylamino-dimethyl acridinium ester (DHEAS-CMO-DMAE) conjugate. Also disclosed are immunoassay kits and devices that contain one or more of the DHEAS conjugates. Methods of making and using the DHEAS conjugates are further disclosed.
A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing control information, such as an authentication code, encoded as a part of a non-visible code. The authentication code may be used to determine if the reagent strip is authentic before testing is done or results are produced.
G06K 7/12 - Methods or arrangements for sensing record carriers by corpuscular radiation using a selected wavelength, e.g. to sense red marks and ignore blue marks
G01N 21/84 - Systems specially adapted for particular applications
G01N 33/487 - Physical analysis of biological material of liquid biological material
A computer-implemented method for analyzing log files generated by complex physical equipment includes receiving one or more log file generated by one or more components of physical equipment. Each of the log files comprises one or more log entries. A plurality of templates are extracted from each log file describing fixed portions of the log entries. The log entries are grouped in log files into a plurality of instances. Each instance corresponds to one of a plurality of partitions along one or more dimensions describing data in the log entries. A representation of each instance is created that describes a set of the templates included in the instance. A plurality of clusters are generated by applying a clustering process to the representations of the instances. A visual depiction of the clusters and the instances may then be created in a graphical user interface (GUI).
G06F 16/14 - File systems; File servers - Details of searching files based on file metadata
G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
The invention relates to a method for detecting a dengue infection in a patient blood sample, comprising the steps: a) Performing an analysis of prespecified parameters of blood platelets and prespecified types of blood cells in the sample and determining parameter values for the prespecified parameters of the platelets and the prespecified types of cells; b) Obtaining sample parameters from the values determined in step a); and c) Evaluating the sample parameters in relation to a prespecified criterion, wherein, if the criterion is fulfilled, a dengue infection is present.
A method and system for replenishing refrigerated consumables by a mobile connected autonomous refrigerator includes receiving a notification triggered by a laboratory instrument that a refrigerated consumable used by the laboratory instrument is depleted; autonomously navigating to a refrigerated storage; retrieving the refrigerated consumable and placing it in the mobile refrigerated unit; autonomously moving to the laboratory instrument that triggered the notification; and alerting an operator to retrieve the refrigerated consumable from mobile refrigerated unit and load it into the laboratory instrument.
A connector system providing a releasable, liquid-tight seal for a fluid system is provided. The system includes a female connector, having a cylindrical opening, and a male connector, having a tubular end section, which is to be inserted in an insertion direction into the cylindrical opening. Inside the tubular end section, a fluid passage is formed. On an outer circumferential surface of the tubular end section, annular protrusions are integrally formed. When the tubular end section with the annular protrusions is inserted into the cylindrical opening, the intermediate protrusion and the rear protrusion each form a press-fit with the inner circumferential surface of the cylindrical opening, whereby a liquid-tight seal between the male connector and the female connector is generated.
Disclosed herein are compositions and methods for using modified liposomes comprising (i) an encapsulated hydrophilic acridinium ester (AE), and (ii) a first agent encapsulated by the liposomes and/or (iii) a second agent on the surface of the liposomes. Specifically, the disclosed methods provide methods of labeling a target of interest, assaying a biological sample for a target antigen, and detecting a target antigen in a biological sample. Further disclosed herein are methods for increasing the strength of a signal detected by an imaging modality.
A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups
Lateral flow devices, kits, and methods for detecting the presence and/or concentration of anti‐SARS‐CoV‐2 antibodies in a sample are disclosed. In certain non‐limiting embodiments, the lateral flow devices, kits, and methods can distinguish between anti‐SARS‐CoV‐2 antibodies generated in response to vaccination from anti‐SARS‐CoV‐2 antibodies generated in response to infection.
Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of anti-SARS-CoV-2 antibodies in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths. In certain non-limiting embodiments, the kits, microfluidics devices, and methods can distinguish between anti-SARS-CoV-2 antibodies generated in response to vaccination from anti-SARS-CoV-2 antibodies generated in response to infection.
The disclosure relates to a method (100) of optically analyzing a blood cell from a blood sample with a device for optically analyzing a blood cell from a blood sample, the device (1) comprising a microfluidic chamber with at least one fluidic flow-through channel, a first inlet (6) port configured to introduce at least a part of the blood sample into the fluidic channel, a first outlet (7) port configured to discharge at least a part of the blood sample from the fluidic channel, a flow generating and stopping device configured to generate a flow of the sample through the channel and to stop the flow while a least a part of the sample comprising at least one blood cell is situated within the channel and wherein after stopping the flow the sample is only influenced by gravity and inertial forces such that blood cells within the sample sediment on a first area of a lower surface of the channel, wherein cells sedimented within the first area of the lower surface can be optically analyzed in the chamber, and to a hematology analyzer.
Embodiments provide a tube retainer system, including: an outer body; a diaphragm having a circular opening; a valve including a valve head and a valve stem attached to the valve head; a cam; a camshaft extending through the cam; a drive gear attached to the camshaft; a restraint gear attached to the camshaft; a push bar located below the diaphragm; and a pawl. The diaphragm, the cam, the drive gear, the restraint gear, the push bar, and the pawl are all provided in the outer body, when a bottom of a tube is inserted into the circular opening and a downward pressure is applied on the diaphragm, the cam is oriented to close the valve to form a partial vacuum in the outer body to secure the bottom of the tube within the circular opening.
The disclosure provides a computer-implemented method for detecting a failure of a device, wherein the device is connected to a sensor, the method comprising: receiving, by a machine learning model, a trace signal from the sensor indicating a status of the device; encoding, by the machine learning model, the trace signal into a plurality of vector representations; and determining, by the machine learning model, whether the trace signal is valid or invalid based on the plurality of vector representations.
A method and a kit for detecting one or more analytes in a sample is disclosed. In one aspect, the method includes introducing the sample to a surface bound to at least one portion of a first antibody to form a first antibody-analyte complex. The method further includes incubating the first antibody-analyte complex with a set of second antibodies to form a first antibody-analyte-second antibody complex, wherein one second antibody is conjugated with a nucleic acid fragment comprising an exposed 3′ hydroxyl group and another second antibody is conjugated with an exposed 5′ phosphate group. Additionally, the method includes ligating the nucleic acid fragment comprising the exposed 3′ hydroxyl group and the nucleic acid fragment comprising the exposed 5′ phosphate group. Furthermore, the method includes separating the ligated nucleic acid fragments from the first antibody-analyte-second antibody complex.
C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups
Disclosed herein are methods for using modified liposomes or carrier proteins comprising (i) an acridinium ester (AE), and (ii) a first agent encapsulated by the liposomes and/or (iii) a second agent on the surface of the liposomes or the carrier proteins. Specifically, the disclosed methods provide methods of labeling a target of interest, assaying a biological sample for a target antigen, and detecting a target antigen in a biological sample. Further disclosed herein are methods for increasing the strength of a signal detected by an imaging modality.
The present disclosure provides methods and kits for identifying and treating individuals at risk of or suffering from amyloid transthyretin cardiomyopathy. In general, detection or measurement of one or more biomarkers, such as TnI, PKM1, PKM2, NT-proBNP, RBP4, DCN, TIMP2, SMOC-2, NfL, or combinations thereof, assists in the identification of amyloid transthyretin cardiomyopathy. The present disclosure also provides methods for selecting patients for treatment of amyloid transthyretin cardiomyopathy, such as with transthyretin stabilizing agents.
A method of performing a study using one or more laboratory analyzers includes displaying on a display one or more evaluation studies performable on the one or more laboratory analyzers; receiving a selected evaluation study to be performed on the one or more laboratory analyzers from the one or more evaluation studies; generating, by a processor, instructions configured to operate the one or more laboratory analyzers to perform the evaluation study; and executing the instructions in the one or more laboratory analyzers. The instructions cause the one or more laboratory analyzers to perform an analysis using one or more test materials in response to the selected evaluation study. Other methods and apparatus are disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
An optical discrimination apparatus adapted for use in PCR testing and the like. The apparatus includes a multi-color light emitter to emit excitation light, a sample holder configured to hold dye-marked nucleic acid fragments in a PCR solution at a position configured to receive the excitation light along a first direction, light emission collection optics configured to collect scattered excitation light and light emission (fluorescent emission) from the sample holder along a second direction that is approximately orthogonal to the first direction, a spectrally-dispersive element configured to spectrally disperse scattered light and emission light, and a spectral detector configured to receive the separated emission light and excitation light on different photosites of the spectral detector. Systems and methods are provided, as are other aspects.
The invention relates to a method for digitally staining a cell and/or a medical preparation, the method comprising the following steps: determining three-dimensional information of a cell and/or of a medical preparation by means of an analyser for analysing a medical sample, the analyser comprising an apparatus for determining the three-dimensional information of the cell and/or of the medical preparation; digitally staining the cell and/or the medical preparation according to a predetermined correlation between the three-dimensional information of the cell and/or of the medical preparation and the staining of a corresponding cell and/or medical preparation and/or cellular and/or sub-cellular structures of the cell and/or of the medical preparation by means of a staining protocol; representing the digitally stained cell and/or the preparation, the representation involving a predetermined defocus region, and regions of the cell and/or of the preparation being represented by means of different digital staining in the area of the defocus region as corresponding modulations of colour intensities and/or as mixed colour.
A sample holder for PCR processing. The sample holder includes a body with an inlet and outlet grooves formed alongside each other, a detection recess that is connected to the inlet and outlet grooves, and a fill port interconnected to both the inlet and outlet grooves, and a cover interfacing with the body to form an inlet channel interconnected to the fill port, a detection region interconnected to the inlet channel, and an outlet channel interconnected to the detection region and the fill port. The detection region is configured to receive a PCR solution from the fill port and replication occurs within the detection region via heating and cooling cycles. Thereafter, fluorescent emissions from tagged replicated DNA/RNA in the detection region are detected and measured. PCR stations, PCR station assemblies, PCR testing systems, and methods of operating a PCR testing systems are provided, as are other aspects.
An apparatus, vortex generator assembly and method for automated cell lysis and nucleic acid purification and processing. The vortex generator assembly includes sample holder having a lysis well, at least one wash well, and an elution well. The vortex generator assembly also includes a sample holder cover having a plurality of vibration rods for creating a vortex in the wells of the sample holder. The apparatus includes motor operating a rotating cam to cause the vibration rods to vibrate and create the vortex in a well holding fluid and magnetic beads, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and disperse the beads in solution, to collect nucleic acids such as DNA.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01F 31/441 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
B01F 31/44 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
B01F 33/452 - Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
An apparatus and method for removing bubbles from a fluid sample. The apparatus has a barrel and a filter member. The barrel has a first end, a second end, a sidewall, and an inner surface defining an internal chamber. The first side has an inlet opening and the second side has an outlet opening. The filter member is disposed within the internal chamber and defines an inlet side and an outlet side of the internal chamber. The filter member has a gas-permeable, liquid-impermeable membrane which permits the gas portion of the fluid sample to pass across the filter member from the inlet side to the outlet side. The gas-permeable, liquid-impermeable membrane provides a fluid-tight seal across the filter member. The filter member is pierceable so a probe may be passed through the filter member to withdraw the liquid portion of the fluid sample from the internal chamber.
A dynamometer includes a torque measuring device configured to measure torque applied to the torque measuring device; a clutch having a clutch input and a clutch output, the clutch output coupled to the torque measuring device and the clutch input configured to be coupled to a motor under test; wherein friction between the clutch input and the clutch output is variable; and a dampening mechanism configured to dampen the friction between the clutch input and the clutch output. Other dynamometers and methods of measuring torque are disclosed.
F16F 9/00 - Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
G01L 3/14 - Rotary-transmission dynamometers wherein the torque-transmitting element is other than a torsionally-flexible shaft
G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
G01L 5/26 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for determining the characteristic of torque in relation to revolutions per unit of time
G01L 3/00 - Measuring torque, work, mechanical power, or mechanical efficiency, in general
84.
A HEMATOLOGY ANALYZER COMPRISING A SINGLE HARDWARE MODULE AND INTEGRATED WORKFLOW
The disclosure relates to a device and method for analyzing a blood sample, particularly including pre-analytical (qualification), analytical and post-analytical (verification) testing. More particularly the disclosure relates in certain embodiments to a device configured for collecting, imaging and lysing blood cells in a sample vessel by means of ultrasonic acoustic waves, generated in the vessel by an acoustic transducer driven at one particular excitation frequency or more particular excitation frequencies, or one range of frequency or ranges of frequencies. In some non-limiting embodiments, the ultrasonic acoustic waves are generated by a single acoustic transducer. Further on, according to certain embodiments, the device and workflow are configured for three analytical steps in single device, comprising pre-analytical (qualification), analytical and post-analytical (verification) testing.
An apparatus and method for removing bubbles from a fluid sample. The apparatus has a barrel and a filter member. The barrel has a first end, a second end, a sidewall, and an inner surface defining an internal chamber. The first side has an inlet opening and the second side has an outlet opening. The filter member is slidably disposed within the internal chamber and defines an inlet side and an outlet side of the internal chamber. The filter member has a gas-permeable, liquid-impermeable membrane which permits the gas portion of the fluid sample to pass across the filter member. The barrel has a second gas-permeable, liquid-impermeable membrane which provides a fluid-tight seal across the outlet opening.
An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, and an inner surface defining an internal chamber. The first end has an inlet opening and the second end having an outlet opening. The first end of the barrel has a barrel connection portion engageable with a portion of the fluid sample collection apparatus and the second end of the barrel has a tubular portion configured to engage with the liquid sample analyzer so a combination of the fluid sample collection apparatus and the barrel is attachable to the liquid sample analyzer with no additional support.
An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, an inner surface defining an internal chamber, and an external surface defining at least a portion of a chromatographic assay chamber in fluid communication with the internal chamber. The first end has an inlet opening with a clot catcher extending across the inlet opening upstream of the passage and the second end has an outlet opening. A chromatographic assay assembly is housed in the chromatographic assay chamber for detecting presence of free hemoglobin in the fluid sample.
Liquid supply system for an analyzer. Liquid supply system includes a liquid-containing container and a spout support tool. Liquid-containing container is made up of a rectangular parallelepiped box comprising a wall with an opening therein, and a collapsible insert including a liquid-containing portion received inside the rectangular parallelepiped box. The collapsible insert includes a spout with a flange wherein both are retractable through the opening. The support tool has a body having an engaging portion and a grasping portion, the engaging portion includes a first engagement surface engaged with a surface of the wall, a second engagement surface, and a spout receiver formed in the engaging portion that is configured to be received under the flange to support the spout. pout support tools and retaining methods of a liquid supply system are provided, as are other aspects.
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
B65D 25/44 - Telescopic or retractable nozzles or spouts
F16L 3/123 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets substantially surrounding the pipe, cable or protective tubing comprising a member substantially surrounding the pipe, cable or protective tubing and extending along the attachment surface
89.
COMPOSITIONS, KITS, AND METHODS FOR PERFORMING RAPID POLYMERASE CHAIN REACTIONS
Compositions, kits, and methods for performing rapid polymerase chain reaction (PCR) to amplify a target nucleic acid in a biological sample are disclosed. The methods include the use of at least one hybridization stabilizer and/or the adjustment of the thermocycling profiles between initiation and propagation phases of the amplification process. Also disclosed are methods of detecting the target nucleic acid following amplification thereof, as well as reaction mixtures that may be utilized in said methods.
A method for backlash compensation in motion control systems includes homing a payload of a motion control system, and performing a tooth-pitch non-uniformity procedure on the motion control system to identify a non-uniformity correction. A backlash lookup table is generated for use in backlash correction during normal operation of the motion control system. The backlash lookup table is generated using a training process that includes selecting a move sequence for operating the motion control system, and executing the move sequence with the non-uniformity correction. The training process further includes computing a backlash measurement describing backlash of one or more components of the motion control system during the move sequence, and storing the backlash measurement in the backlash lookup table.
G05B 19/404 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control arrangements for compensation, e.g. for backlash, overshoot, tool offset, tool wear, temperature, machine construction errors, load, inertia
H02P 8/00 - Arrangements for controlling dynamo-electric motors rotating step by step
The invention relates to a medical diagnosis assistance system, a medical diagnosis assistance method, and a training method for training an artificial intelligence entity. The medical diagnosis assistance system (100) comprises:
an input interface (110) configured to receive medical image data (1) of a patient;
a computing device (150) configured to implement:
a classification module (151) configured to classify parts of interest, POI (10, 11, 12, 13, 14, 15, 20, 30), comprising objects of interest, OOI, and/or regions of interest, ROI, within the received medical image data (1), and to assign a corresponding reliability metric to each of the classified POI (10, 11, 12, 13, 14, 15, 20, 30);
an analysis module (152) configured to determine, based on the POI (10, 11, 12, 13, 14, 15, 20, 30) and the assigned reliability metric, an analysis of the medical image data (1);
and
an output interface (190) configured to output an output signal (71) indicating the analysis.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
92.
PERFORMANCE VISUALIZATION METHODS AND DIAGNOSTIC LABORATORY SYSTEMS INCLUDING SAME
Methods of visualizing performance of a diagnostic laboratory system are provided. The methods include displaying on a display, an image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and overlaying the image with a dynamically-changeable color overlay that indicates a performance for the plurality of laboratory analyzers over a period of time via using changeable colors. Systems including color-changeable overlays are provided as are other aspects.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
An apparatus configured to receive particles in a liquid includes: a housing comprising a housing inlet and a housing outlet; and a mesh located in the housing between the housing inlet and the housing outlet, the mesh having spaces greater than a greatest transverse dimension of the particles. The apparatus operates to break up agglomerates of the particles, such as agglomerates of magnetic particles. Other systems and methods of receiving and transferring liquids containing particles having a propensity to agglomerate are disclosed, as are other aspects.
Methods of early real-time detection or prediction of aspiration faults in an automated diagnostic analysis system include an artificial intelligence algorithm configured to use either cluster analysis or probabilistic graphical modeling based on an aspiration pressure measurement signal waveform. Aspiration faults may include short-volume aspiration and unwanted gel pick-up. These methods may allow for timely termination of an aspiration process so as to avoid or minimize possible detrimental downstream consequences such as faulty sample test results and/or instrument downtime for servicing and cleanup. Apparatus for early real-time detection or prediction of aspiration faults are provided as are other aspects.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Methods of real-time detection of short-sample aspiration faults in an automated diagnostic analysis system include spectral analysis of a pressure slope waveform based on aspiration pressure measurement signals. The spectral analysis may include using a moving average filter or a wavelet transform, such as, e.g., a continuous wavelet transform (CWT) or a discrete wavelet transform (DWT), to identify distinct transient behavior in the pressure slope waveform. These methods accurately identify short-sample aspiration faults such that an automated diagnostic analysis system can timely terminate an analysis of a detected short sample to avoid a possibly erroneous sample test result. Apparatus for real-time detection of short-sample aspiration faults is also provided, as are other aspects.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
96.
MAGNETIC MANIPULATION THROUGH SOLID-STATE METHOD AND APPARATUS
An apparatus and method for extracting nucleic acids such as DNA molecules from biological samples uses solid-state magnetic manipulation. A fluid sample and magnetic beads are placed in a vessel. The vessel is placed in a housing with an array of electromagnets mounted therein. The electromagnets are energized sequentially or in groups to move the magnetic beads through the fluid sample in a variety of patterns. The apparatus disclosed herein may be used as a measurement device to measure bead number density and modify magnetic patterns in order to deliver consistent dosages in bead number.
B01F 33/451 - Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
97.
DETECTION OF ABNORMAL HEAT EXCHANGER OPERATING CONDITION
A method for detecting an abnormal operating condition of a heat exchanger is provided. The method includes determining the actual current through a heat exchanger, using the actual current to indicate an abnormal operating condition, and declaring a fault state. A step of comparing the baseline current to the actual current includes normalizing the actual current, calculating a difference between the normalized actual current and the baseline current, and determining that difference is less than zero.
A quality control method for a diagnostic analyzer includes performing a quality control test or a plurality of specimen tests; determining, with a controller, that a result of the quality control test or a plurality of specimen test results is outside of a threshold; monitoring one or more mechanical devices of the diagnostic analyzer with the controller; receiving, by the controller, an error code indicating an error in a mechanical device of the one or more mechanical devices; and initiating a calibration procedure in response to the result of the quality control test or the plurality of specimen test results being outside of the threshold and receiving the error code. Other apparatus and methods are disclosed.
A method (200), and a system (100) for processing medical images is provided. In one aspect, the method (200) includes receiving the medical image, wherein the medical image comprises a plurality of objects, wherein the medical image is a low-resolution image. Further, the method (200) includes segmenting at least one object from the plurality of objects from the medical image. Additionally, the method (200) includes identifying at least one region of interest in the medical image, wherein the region of interest comprises the at least one object, wherein the at least one object is clinically relevant. Furthermore, the method (200) includes generating a high-resolution image of the region of interest. The method also includes displaying the high-resolution image of the region of interest on a display unit.
Methods of characterizing a sample container or a biological sample in an automated diagnostic analysis system using an artificial intelligence (AI) algorithm include retraining of the AI algorithm in response to characterization confidence levels determined to be unsatisfactory. The AI algorithm is retrained with data (including image data and/or non-image data) having features prevalent at the site where the automated diagnostic analysis system is operated, which were not sufficiently or at all included in training data used to initially train the AI algorithm. Systems for characterizing a sample container or a biological sample using an AI algorithm are also provided, as are other aspects.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
