The present disclosure provides a compound function prediction method based on a neural network and a connectivity map (CMAP) algorithm. The compound function prediction method is used to predict an efficacy of a compound, and the compound function prediction method includes the following steps: constructing a compound molecule—encoding vector neural network; constructing and training an encoding vector—marker gene expression variation deep neural network; constructing and training a marker gene expression level or gene expression variation—whole genome gene expression level or gene expression variation neural network; constructing upregulated and downregulated gene sets of a disease or a phenotype; and evaluating a correlation between the compound and the disease or the phenotype.
A quantitative source apportionment method based on nontarget high-resolution mass spectrometry (HRMS) data of pollution sources and pollution receptors includes: acquiring samples of pollution sources and receptors, pre-processing samples to extract trace organic pollutants; acquiring chromatography-HRMS nontarget data; pre-processing raw data to obtain a HRMS dataset including a mass-to-charge ratio, a retention time, and a peak area; determining a source-sink relationship based on positions of pollution sources and receptors; constructing an input matrix by combining the HRMS dataset and using each sink as a group; adopting an expectation-maximization method or a Bayesian method to calculate contribution of each source based on a standardized input matrix. Beneficial effects at least include the follows. (1) The HRMS is used to acquire data to, information of the pollution source chemical fingerprint is rich and accurate; (2) contributions of different pollution sources to the receptor are quantitatively evaluated by using statistical algorithms.
A device and method for preparing a thermosetting bonded magnet are provided, the device includes a compressed air glue feeding tank and a composite-function mold. A feeding end of the compressed air glue feeding tank is connected to the composite-function mold. The composite-function mold includes a housing, the housing is disposed at an upper end and a lower end of the composite-function mold, and the housing includes a polytetrafluoroethylene upper cover and a polytetrafluoroethylene lower cover; the polytetrafluoroethylene upper cover and the polytetrafluoroethylene lower cover are respectively disposed at the upper end and the lower end of composite-function mold. The method uses a silica gel material as a binder for anisotropic magnets, and the selected raw materials and process are suitable for quickly obtaining a uniform magnet slurry. The curing process is controllable, and there is no organic solvent or heating during the mixing process.
H01F 41/02 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateurs; Appareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants
4.
Natural gas separation and purification and mercury collection system for oil and gas wells, and method of use thereof
A natural gas separation and purification and mercury collection system for oil and gas wells includes a cyclone separator, a condensation purification and separation mechanism, pressure buffer mechanisms, mercury collection and separation mechanisms, and natural gas storage tanks. An inlet end of the cyclone separator is communicated with an external gas source through a pressure buffer mechanism, and an outlet end of the cyclone separator is communicated with the condensation purification and separation mechanism through a pressure buffer mechanism. The condensation purification and separation mechanism is communicated with the mercury collection and separation mechanism through a pressure buffer mechanism. The mercury collection and separation mechanism is communicated with the natural gas storage tank through a guide tube. A method of use of the natural gas separation and purification and mercury collection system includes gas collection, gas purification, mercury separation, and mercury analysis.
B01D 45/16 - Séparation de particules dispersées dans des gaz ou des vapeurs par gravité, inertie ou force centrifuge en utilisant la force centrifuge produite par le mouvement hélicoïdal du courant gazeux
B01D 53/00 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols
B01D 53/30 - Commande par appareil d'analyse des gaz
C10L 3/10 - Post-traitement de gaz naturel ou de gaz naturel de synthèse
5.
FLEXIBLE PERMANENT MAGNETIC MATERIAL, PREPARATION METHOD AND APPLICATION THEREOF IN MAGNETIC BIOLOGICAL EFFECT PRODUCTS
A flexible permanent magnetic material, a preparation method and an application thereof in magnetic biological effect products are provides, relating to the technical field of medical equipment. Raw materials of the flexible permanent magnetic material of the application include the following components in parts by weight: 0-70 parts of anisotropic neodymium iron boron powder and 0-40 parts of anisotropic samarium iron nitrogen powder and 3-20 parts of binder.
H01F 1/057 - Alliages caractérisés par leur composition contenant des métaux des terres rares et des métaux de transition magnétiques, p.ex. SmCo5 et des éléments IIIa, p.ex. Nd2Fe14B
B22F 3/00 - Fabrication de pièces ou d'objets à partir de poudres métalliques, caractérisée par le mode de compactage ou de frittage; Appareils spécialement adaptés à cet effet
B22F 3/087 - Compactage seul utilisant des impulsions de haute énergie, p.ex. des impulsions de champ magnétique
H01F 41/00 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateurs; Appareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques
6.
PROCESS FOR PREPARING CARBOXYL CYCLIC ACID ANHYDRIDE
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).
The present disclosure provides a method for improving stability of an electrochemical sensor. The method includes the following steps: S1, manufacturing an electrochemical sensor; S2, immobilizing a biosensitive molecular enzyme on a working electrode of the electrochemical sensor; S3, setting a immobilization agent on a surface of the biosensitive molecular enzyme; and S4, adding a protective film on a surface of the immobilization agent, such that the protective film is deposited on the working electrode to improve the stability of the electrochemical sensor. In the present disclosure, glutaraldehyde (GA), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), or polyaniline (PANI), the GA, the PVA, the PEG, and polyurethane (PU) are arranged on a surface of the biosensitive molecular enzyme. Therefore, the surface of the biosensitive molecular enzyme forms a composite protective film, which reduces a probability of direct exposure of an enzyme layer to the air.
C08L 29/04 - Alcool polyvinylique; Homopolymères ou copolymères d'esters partiellement hydrolysés d'alcools non saturés avec des acides carboxyliques saturés
C08L 79/00 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant uniquement de l'azote, avec ou sans oxygène ou carbone, non prévues dans les groupes
Disclosed are a GaN power device and a manufacturing method thereof. The GaN power device includes a substrate, and a buffer layer, a GaN channel layer and a barrier layer sequentially stacked on the substrate from bottom to top. The barrier layer is provided with a p-GaN cap layer and a p-GaN thin layer, and the p-GaN thin layer is configured to cover the surface of the barrier layer and is connected to the p-GaN cap layer; the upper surface of the barrier layer is also provided with an input electrode and an output electrode, and a control electrode is provided on the upper surface of the p-GaN cap layer. The control electrode and the p-GaN thin layer are located between the input electrode and the output electrode.
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 29/739 - Dispositifs du type transistor, c.à d. susceptibles de répondre en continu aux signaux de commande appliqués commandés par effet de champ
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
9.
AUTOMATIC MONITORING SYSTEM FOR SOLUTION-PHASE SYNTHESIS
Disclosed is an automatic monitoring system for solution-phase synthesis, including a new type reactor, a sampling module, a power module, a monitoring analysis module and an upper computer, where the sampling module is connected to a pipe of the power module, the power module is connected to a pipe of the monitoring analysis module, the sampling module, the power module and the monitoring analysis module are electrically connected to the upper computer; the sampling module sucks a reaction solution contained in the new type reactor, the power module provides suction force for the sampling module according to suction instruction from the upper computer, injects the reaction solution into the monitoring analysis module, the monitoring analysis module generates a monitoring report according to the reaction solution, transmit the monitoring report to the upper computer, and the upper computer generates an analysis result according to the monitoring report.
An assistant system for solution-phase synthesis is disclosed. The assistant system for solution-phase synthesis includes: a reactor (1), a mixing device (2), a temperature control device (3) and a host computer (4). The reactor (1) is arranged on the mixing device (2), the mixing device (2) and the temperature control device (3) are both electrically connected to the host computer (4), so as to implement programmed temperature control over the entire assistant system for solution-phase synthesis. A bottle body (15) of the reactor (1) is arranged to include a reaction inner container (151), a temperature circulating layer (152) and a vacuum layer (153) from inside to outside in sequence.
B01J 19/18 - Réacteurs fixes avec éléments internes mobiles
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaire; Appareils à cet usage utilisant des radiations électromagnétiques
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
11.
AUTOMATIC PREPARATION METHOD OF FONDAPARINUX SODIUM PENTOSACCHARIDE INTERMEDIATE
An automatic preparation method of a fondaparinux sodium pentosaccharide intermediate is provided via an automatic preparation device. In the preparation method, the automatic preparation of three components (D+EF+GH) is realized through automatic sampling and monitoring, and a fully-protected fondaparinux sodium pentosaccharide intermediate (shown in formula I) is obtained. In this way, automatic synthesis of the fondaparinux sodium pentosaccharide intermediate is realized, which saves manpower and improves efficiency and productivity, and has high safety and reproducibility. The preparation method can be directly monitored online, which is convenient for optimizing and monitoring a real-time status of reactions. Furthermore, automatic temperature control can better meet the needs of the reactions for temperature rise and fall. The preparation method adopts a “pre-activation” one-pot mode, which reduces the number of separations and is easy to operate. Moreover, the method selects commonly-used ester protecting groups, has higher stereoselectivity and yield, and can use general-purpose deprotection measures.
An automated solution-phase synthesizer is provided with an automatic sample injection system, an assisting system for solution-phase synthesis, an automatic online monitoring system for solution-phase synthesis and a master computer. The automatic sample injection system completes an automatic sample injection operation according to a sample injection instruction from the master computer. The assisting system for solution-phase synthesis controls temperature and illumination of a solution to undergo reaction according to a temperature control instruction and an illumination control instruction from the master computer. The automatic online monitoring system for solution-phase synthesis monitors a reaction solution and generates a monitoring report. And, the master computer generates an experimental analysis result according to the monitoring report. In this way, an automatic process from sample injection to report generation in a solution-phase experiment process is completed, and further experimental labor cost is reduced and experimental efficiency is improved.
An automatic sample injection system is disclosed. The system includes: an inert gas conveying module (1), a sampling channel switching module (2), a quantification module (3), a disposal module (4), a liquid storage module (5), and a host computer. The host computer controls the sampling channel switching module (2) and the quantification module (3), so as to achieve accurate control of a sample injection amount. In addition, all reaction liquids can be independently conveyed separately by the sampling channel switching module (2) and the inert gas conveying module (1), such that stability and accuracy of sample injection are further improved, and accuracy of experimental reactions is ensured.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p.ex. dispositifs d'aspiration, dispositifs d'injection
14.
SVM MODEL TRAINING METHOD AND APPARATUS, DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM
The embodiments of the present disclosure provide a method and apparatus for training an SVM model, a device and a computer-readable storage medium. The method comprises steps of: acquiring a dataset; loading the dataset; predicting the best storage format of the dataset online through an automatic tuning framework, and performing format conversion; and, executing an SMO algorithm to train an SVM model. In this way, the best data storage format and algorithm can be automatically selected according to the input dataset; in a global loop level, a large number of more efficient matrix multiplication operations are performed on the basis of the best data storage format to calculate a kernel matrix; and, in a local SMO solver level, finer memory optimization is performed by the register communication technology and the combined memory access method of the GPU, and the calculation resources of the hardware platform are fully utilized.
The present disclosure provides an application of RNA-dependent RNA polymerase (RDR) in treatment of cell proliferative diseases. The RDR can be widely used for inhibiting cell proliferation, apoptosis and migration of various tumors, thereby providing a new choice for clinical treatment of tumors.
Provided is a Pt(IV) complex. As a prodrug, the Pt(IV) complex is activated by irradiation to release a Pt(II) complex for the treatment of tumors. Also provided is a pharmaceutical composition including the Pt(IV) complex, and the use of the Pt(IV) complex in the preparation of a drug for treating tumors by means of irradiation activation. Further provided is a kit including the Pt(IV) complex and the description, wherein the description indicates that radiotherapy is performed after administration to treat tumors.
Peking University Ordos Research Institute of Energy (Chine)
Inventeur(s)
Wang, Jianxiao
He, Guannan
Gao, Feng
Huang, Jingsi
Song, Jie
Abrégé
A method for coordinated control of an electro-hydrogen integrated system includes: constructing a clearing model for the integrated system having a fuel cell facility and a P2H production facility; introducing Lagrange multipliers into a power balance constraint and a hydrogen energy balance constraint in the clearing model; decomposing the clearing model into a first clearing model of a power subsystem and a second clearing model of a hydrogen subsystem based on a decomposition algorithm, solving the first and second clearing models to obtain interaction information; storing the interaction information in a blockchain smart contract, exchanging the blockchain smart contract for multiple rounds and adjusting strategies of each subsystem to obtain an optimal solution of the clearing model; and controlling the integrated system based on the optimal solution to provide a target electric quantity and a target hydrogen amount.
H01M 8/22 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible dans lesquels le combustible est à base de matériaux comprenant uniquement des éléments autres que le carbone, l'oxygène ou l'hydrogène
18.
RADIATION-ACTIVATED TETRAVALENT PLATINUM COMPLEX AND USE THEREOF
The present disclosure provides a complex of general formula (I), wherein M is tetravalent platinum; L is independently a neutral ligand or an anionic ligand when appearing each time; x is an integer of 1-5; P is a precursor ligand, the precursor ligand being a ligand of a tetravalent platinum ion which can be released from the complex after irradiation and converted into a functional molecule D to achieve functions such as medicine, fluorescence detection, or a functional material.
The present disclosure provides a complex of general formula (I), wherein M is tetravalent platinum; L is independently a neutral ligand or an anionic ligand when appearing each time; x is an integer of 1-5; P is a precursor ligand, the precursor ligand being a ligand of a tetravalent platinum ion which can be released from the complex after irradiation and converted into a functional molecule D to achieve functions such as medicine, fluorescence detection, or a functional material.
Lx-M-P (I)
A drug injection device based on an electrochemical reaction and a fabrication method for a drug injection pump, belonging to the technical field of medical devices are provided. A driving force is generated based on electrochemical reaction, and drug solution is automatically driven by the driving force to administer a drug to a patient. Meanwhile, three specific structures of the drug injection device based on the electrochemical reaction are provided, namely, a first drug injection pump based on electrochemical reaction, an insulin injection system, and a closed-loop control system, which can achieve the automation of the drug administration process.
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte électriques ou électroniques
A61M 5/142 - Perfusion sous pression, p.ex. utilisant des pompes
20.
LIQUID CRYSTAL/POLYMER COMPOSITE ELECTRICALLY CONTROLLED DIMMING FILMS AND PREPARATION METHODS THEREOF
A liquid crystal/polymer composite electrically controlled dimming film is provided, including a liquid crystal material, a polymer matrix, and two layers of conductive substrates. The polymer matrix is sandwiched between the two layers of conductive substrates, and the polymer matrix has a porous microstructure. The liquid crystal material is dispersed in the polymer matrix to form liquid crystal microdroplets, and the liquid crystal microdroplets have vertically oriented polymer networks. The liquid crystal/polymer composite electrically controlled dimming film has a unique composite microstructure. In this composite microstructure, the polymer matrix of the porous microstructure gives the film with good mechanical processing performance. In addition, the vertically oriented polymer networks in the liquid crystal microdroplets further reduces the orientation difficulty of liquid crystal molecules, which is conducive to reducing the driving voltage of the liquid crystal/polymer composite electrically controlled dimming film, and is suitable for large area processing and production.
G02F 1/1334 - Dispositions relatives à la structure basées sur des cristaux liquides dispersés dans un polymère, p.ex. cristaux liquides micro-encapsulés
G02F 1/137 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des cristaux liquides, p.ex. cellules d'affichage individuelles à cristaux liquides caractérisés par l'effet électro-optique ou magnéto-optique, p.ex. transition de phase induite par un champ, effet d'orientation, interaction entre milieu récepteur et matière additive ou diffusion dynamique
G02F 1/1341 - Remplissage ou fermeture des cellules
C09K 19/54 - Additifs n'ayant pas de mésophase spécifique
21.
Device and method for testing effective diffusion coefficient of helium in helium-bearing natural gas
A device and method for testing an effective diffusion coefficient of helium in helium-bearing natural gas solves the problem that there is currently no systematic method or supporting experimental device to quantitatively characterize the diffusion behavior of helium in helium-bearing natural gas. The device includes a diffusion system and a gas sampling and analysis system. The diffusion system includes an upstream diffusion chamber, a downstream diffusion chamber, and a true triaxial apparatus, and is configured to simulate a gas diffusion process. The gas sampling and analysis system includes an upstream gas sample retention chamber, a downstream gas sample retention chamber, and a chromatographic analyzer, and is configured to sample a diffusing gas and analyze composition of the gas. By performing diffusion process simulation, gas sampling and analysis, and data calculation and fitting, the effective diffusion coefficient of helium in the helium-bearing natural gas is finally acquired.
G01N 13/00 - Recherche des effets de surface ou de couche limite, p.ex. pouvoir mouillant; Recherche des effets de diffusion; Analyse des matériaux en déterminant les effets superficiels, limites ou de diffusion
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
22.
SIRNA, MEDICAL COMPOSITIONS, AND METHODS FOR TREATING DIABETES USING THE SAME
Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5′-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.
A method for fabricating a vertical channel nanowire transistor with asymmetric stress distribution includes: (A) growing epitaxially a single-crystal material on a substrate; forming a laminate of a bottom source-drain material and a channel material; and generating a vertical uniaxial stress in the lightly-doped channel layer; (B) forming an inter-device isolation in an active layer; (C) forming a vertical channel by patterning; (D) depositing a dielectric layer to form a bottom gate isolation; (E) depositing a dummy gate layer followed by patterning to form a dummy gate pattern; (F) depositing a dielectric layer to form a top gate isolation; (G) patterning the top gate isolation; and forming a top source-drain by epitaxy growth; (H) removing a dummy gate; and forming a gate oxide layer and a metal gate; and (I) forming metal contact at individual ends of the device.
H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
H01L 29/423 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative ne transportant pas le courant à redresser, à amplifier ou à commuter
A method for fabricating a gate-all-around (GAA) structure, including: etching a superlattice laminate to form active regions; performing selective epitaxy growth of a silicon germanium (SiGe) layer to form a SiGe-wrapped Si nanosheet stacked structure, where the SiGe layer and the SiGe/Silicon (Si) periodic superlattice laminate have the same germanium (Ge) content; after silicon oxide is backfilled and chemical mechanical polishing (CMP) is performed on the active regions, performing an amorphous-silicon dummy-gate process on a top of the active regions; removing dummy gate, and selectively etching the SiGe layer; and forming hole-trench structures connected with trenches of the dummy gate around the Si nanosheet stacked structure.
The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.
A computer-implemented method for data processing based on a data value includes: calculating a value of each piece of original data based on a utility function associated with a service revenue; acquiring pieces of high-value data from the original data based on the value of each piece of original data; and performing a service prediction on the pieces of high-value data.
A method for constructing a real-geographic-space scene in real time based on a panoramic-video technique is provided. By using a measuring robot and the attitude sensors, accurately determining the geographic coordinates and the attitudes of the cameras, where the cameras may be installed in a fixed or stringing manner, where in the fixing type a plurality of neighboring videos at the same moment undergo orthographic correction and splicing, and in the stringing type the cameras are installed to a guiding device and may locally, independently and quickly move and shoot, and the videos of the neighboring cameras are spliced in real time; and fusing the videos, the geographic coordinates and the environment sounds that satisfy the delay time, to form a scene video streaming.
H04N 23/661 - Transmission des signaux de commande de la caméra par le biais de réseaux, p. ex. la commande via Internet
H04N 23/695 - Commande de la direction de la caméra pour modifier le champ de vision, p. ex. par un panoramique, une inclinaison ou en fonction du suivi des objets
G06T 5/50 - Amélioration ou restauration d'image en utilisant plusieurs images, p.ex. moyenne, soustraction
28.
CONTEXTUAL INSTANCE DECOUPLING-BASED MULTI-PERSON POSE ESTIMATION METHOD AND APPARATUS
The present application relates to the technical field of deep learning and pose estimation, and more particularly, to a contextual instance decoupling (CID)-based multi-person pose estimation (MPPE) method and apparatus. The method includes: acquiring a preset number of images containing multiple persons; inputting the images containing multiple persons, as a training sample, into a CID-based MPPE model for training; and performing pose estimation on a target image using the trained CID-based MPPE model, the CID-based MPPE model being provided with an instance information abstraction module, a global feature decoupling module and a heatmap estimation module. The method and apparatus of the present application can explore context clues over a greater range, thus being robust to spatial detection errors and superior in both accuracy and efficiency.
Provided is a method for biosynthesis of a protein heterocatenane. The basic structure of a protein precursor sequence of the protein heterocatenane comprises form an N-terminal to a C-terminal: L1-1-X-L1-2-(in situ enzyme cutting site)-L2-1-X-L2-2, wherein the Xs represent entangled motifs for forming dimers, the two Xs can be the same or different, L1-1/L1-2 and L2-1/L2-2 represent two pairs of cyclization motifs that undergo an orthogonal coupling reaction in cellulo, and the two pairs of cyclization motifs can be two orthogonal peptide-protein reactive pairs, or combinations of peptide-protein reactive pairs and split inteins, or two orthogonal split inteins. When the peptide-protein reactive pair and the split intein are combined for use, biosynthesis of branched protein heterocatenanes can be achieved; and when the two orthogonal split inteins are combined for use, the protein heterocatenane having a completely cyclized main chain can be obtained.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p.ex. glutathion
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
The present application provides circular RNAs (circRNAs) encoding therapeutic polyeptides (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein). In some embodiments, the present application provides circRNA vaccines against a coronavirus such as SARS-CoV-2. In some embodiments, the circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike (S) protein or a fragment thereof of a coronavirus. Also provided are methods of treating or preventing a disease or condition using the circRNAs or compositions thereof.
A61K 39/215 - Coronaviridae, p.ex. virus de la bronchite infectieuse aviaire
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
31.
NEAR-INFRARED EMITTING PORPHYRIN COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention provides a porphyrin compound and its preparation method and uses, and also provides a pharmaceutical composition comprising the porphyrin compound as the active ingredient. The porphyrin compound according to the present invention has a novel modified structure, and can be derived and modified at multiple sites to achieve the biocompatibility modification and functional changes. The porphyrin compound has the absorption wavelength located in the near infrared region, which is contributed to realize the deeper tissue penetration and excellent photodynamic therapy activity.
C07D 491/22 - Composés hétérocycliques contenant dans le système cyclique condensé, à la fois un ou plusieurs cycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, et un ou plusieurs cycles comportant des atomes d'azote comme uniques hétéro- dans lesquels le système condensé contient au moins quatre hétérocycles
C07D 498/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
32.
ELECTROOSMOTIC PUMP, INSULIN PUMP AND INSULIN PUMP SYSTEM
The present disclosure relates to the technical field of electroosmotic pumps (EOPs) and wearable medical equipment, and in particular, to an EOP, an insulin pump and an insulin pump system. The EOP of the present disclosure is cost-effective and has low power consumption, and can replace an existing mechanical pump device as a driving device in the insulin pump to achieve miniaturization of the insulin pump and lower the price of the insulin pump. In addition, when the EOP adopts a modified flexible membrane with penetrating pores, the EOP can pump and infuse a high-concentration insulin solution to achieve miniaturization and high efficiency of the insulin pump, which is conducive to the integration of wearable medical devices for treating diabetes.
An embodiment of the present application provides a manufacturing method of a microneedle biosensor, and relates to the technical field of medical instruments. The method includes: providing a mold, where a microneedle array is formed on the mold; casting a liquid polymer material on the mold, and drying and then demolding to form a sensor substrate, where a hollow microneedle array is provided on the sensor substrate; penetrating through a tip of each microneedle in the hollow microneedle array; and forming a working electrode and a counter electrode on the sensor substrate, where the working electrode and the counter electrode each cover a part of the hollow microneedle array.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
34.
CHEMICAL TAGGING-BASED METHOD FOR MODIFIED NUCLEOSIDE SEQUENCING, ENRICHMENT, AND MEASUREMENT
Provided is a chemical tagging-based method for modified nucleoside sequencing, enrichment, and measurement, comprising reacting a thiol compound with an N-hydroxymethyl chemically modified nucleoside, then using a chemical tag such as biotin to perform tagging, and then enriching and sequencing or measuring. In the method of the present invention, selective chemical tagging is used, and the selectivity of the chemical reaction ensures result specificity and reduces false positive results.
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le ribosyle comme radical saccharide
C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
35.
Method for implementing adaptive stochastic spiking neuron based on ferroelectric field effect transistor
Disclosed is a method for implementing an adaptive stochastic spiking neuron based on a ferroelectric field effect transistor, relating to the technical field of spiking neurons in neuromorphic computing. Hardware in the method includes a ferroelectric field effect transistor (fefet), an n-type mosfet, and an l-fefet formed by enhancing a polarization degradation characteristic of a ferroelectric material for the ferroelectric field-effect transistor, wherein a series structure of the fefet and the n-type mosfet adaptively modulates a voltage pulse signal transmitted from a synapse. The l-fefet has a gate terminal connected to a source terminal of the fefet to receive the modulated pulse signal, and simulates integration, leakage, and stochastic spike firing characteristics of a biological neuron, thereby implementing an advanced function of adaptive stochastic spike firing of the neuron.
The present invention relates to a boron carrying agent for integrated tumor diagnosis and treatment, and a preparation method therefor and use thereof. Provided is a compound represented by formula I: wherein an R group is hydrogen or alkyl. A boron atom connected to the benzene ring may be 10B or natural boron, and at least one fluorine atom in —BF 3- is radiolabeled. The present invention generally relates to the fields of radiopharmaceuticals and nuclear medicine. The compound in the present invention can be used for a drug for integrated diagnosis and treatment in tumor diagnosis and BNCT treatment, and by means of the same chemical structure, a reliable distribution result of a drug in vivo is provided.
The present disclosure relates to a silicon-based fan out package structure including embedded manifold type microchannels, which includes: a chip, which includes a substrate and embedded microchannels located on a back of the substrate; a silicon-based adapter plate, which includes a groove for burying the chip, a manifold channel located below the groove and communicated with the groove, a liquid inlet and a liquid outlet; a low temperature sealing layer for sealingly communicating the embedded microchannels with the manifold channel, the low temperature sealing layer being located between the chip and the silicon-based adapter plate; and a rewiring layer at a top of the chip. The present disclosure also relates to a preparation method for a silicon-based fan out package structure including embedded manifold type microchannels. The silicon-based fan out package structure of the present disclosure has both low temperature process compatibility and packaging compatibility and high heat dissipation efficiency. The embedded manifold type microchannels of the present disclosure have the advantages of short flow distance, small flow resistance and small thermal resistance, and are more suitable for being integrated in high-power chips for efficient heat dissipation.
H01L 23/473 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température impliquant le transfert de chaleur par des fluides en circulation par une circulation de liquides
H01L 23/427 - Refroidissement par changement d'état, p.ex. caloducs
H01L 21/48 - Fabrication ou traitement de parties, p.ex. de conteneurs, avant l'assemblage des dispositifs, en utilisant des procédés non couverts par l'un uniquement des groupes
The present invention relates to a relay device based on multi-path scheduling, at least comprising: at least one communication-receiving module, at least one hardware interface module, and at least one data-processing module, wherein the data-processing module, according to a specific type of target data, distributes the user data received through the communication-receiving module to a first processing path that processes the data in a predetermined manner and a second processing path that is independent of the first processing path and bypasses a kernel protocol stack. The data-processing module employs a multi-stage continuous scheduling manner to drive the user data in the second processing path to be transmitted in at least two mutually independent communication paths, thereby realizing multi-path transmission between the plural clients and the plural servers. This configuration not only lifts the logic of packet scheduling to the application layer, but also ensures path quality, QoE, and fairness while maintaining the multi-connection, multi-path, application-independent nature.
H04W 72/542 - Critères d’affectation ou de planification des ressources sans fil sur la base de critères de qualité en utilisant la qualité mesurée ou perçue
H04W 72/543 - Critères d’affectation ou de planification des ressources sans fil sur la base de critères de qualité sur la base de la qualité demandée, p.ex. QdS [QoS]
H04W 72/56 - Critères d’affectation ou de planification des ressources sans fil sur la base de critères de priorité
39.
METHOD FOR LOW FREQUENCY SOMATIC CELL MUTATION IDENTIFICATION AND QUANTIFICATION
A method for low frequency somatic cell mutation identification and quantification, relating specifically to a method for transposon copy number and genome location identification. Specific sites of different transposon families are used, transposon insertion sequences are specifically enriched via library construction, high-throughput sequencing and bioinformatics analysis are used, and genome locations, copy numbers and types of transposons within samples are accurately identified. The method economically and accurately identifies copy numbers and genome locations of transposons.
The present disclosure relates to a system and method for capturing movement trajectories of particulate matter. The system includes: micro lidar measurement equipment and a camera. The micro lidar measurement equipment includes: a laser device, a pitching platform, and a protective casing for the laser device, and the laser device is located on the pitching platform. The laser device is configured to emit a laser. The camera is configured to shoot the laser, determine particulate matter concentrations according to a grayscale of pixels and a height of the pixels in a photo shoot, and compare differences in spatial distribution of particulate matter concentrations at different time to obtain the movement trajectories of the particulate matter. The above system and method in the present disclosure can dynamically display 3D temporal and spatial dynamic changes of particulate matter concentrations in real time, can capture the movement trajectories of the particulate matter, and can improve the detection accuracy.
A direct structured illumination microscopy (dSIM) reconstruction method is provided. First, a time domain modulation signal is extracted through a wavelet. Then, an incoherent signal is converted into a coherent signal. Next, an accumulation amount at each pixel is calculated. Finally, a super-resolution image is generated by using a correlation between signals at different spatial positions. An autocorrelation algorithm of dSIM is insensitive to an error of a reconstruction parameter. dSIM bypasses a complex frequency domain operation in structured illumination microscopy (SIM) image reconstruction, and prevents an artifact caused by the parameter error in the frequency domain operation. The dSIM algorithm has high adaptability and can be used in laboratory SIM, nonlinear SIM imaging systems, or commercial systems.
A method for preparing an antibody, relating to the field of immunology and the field of molecular virology, in particular to the field of diagnosis, prevention and treatment of novel coronavirus. Specifically, provided are a monoclonal antibody against novel coronavirus, and a composition (e.g., a diagnostic agent and a therapeutic agent) containing the antibody. Also provided are the preparation, screening, and use of the antibody.
The present invention relates to the fields of immunology and molecular virology, and in particular, to the field of diagnosis, prevention and treatment of a novel coronavirus. Specifically, the present invention relates to an anti-novel coronavirus monoclonal antibody and a composition (for example, a diagnostic agent and a therapeutic agent) containing same. In addition, the present invention also relates to use of the antibody. The antibody of the present invention can be used for diagnosing, preventing and/or treating novel coronavirus infections and/or diseases (for example, novel coronavirus pneumonia) caused by the infections.
C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
A61P 31/14 - Antiviraux pour le traitement des virus ARN
44.
ENERGY FLOW OPTIMIZATION IN MULTI-ENERGY SYSTEM BASED ON SPATIOTEMPORAL NETWORK FLOWS
A method for energy flow optimization in a multi-energy system based on spatiotemporal network flows is disclosed. The multi-energy system includes M energy storage devices, photovoltaic power generators and N micro gas turbines (MGTs). The method includes: obtaining an objective function of the network flows in the multi-energy system; determining constraints of the network flows, where the constraints include a power balance constraint, an energy storage period constraint, an energy storage capacity constraint, an energy storage charging and discharging constraint, a generator power constraint, and an energy storage charge quantity constraint; establishing a network flow model with the objective function and constraints; solving the network flow model with a shortest-path and max-flow algorithm, to obtain an optimal power flow (OPF) in the multi-energy system; operating the multi-energy system by adjusting parameters of the energy storage devices and the MGTs based on the OPF.
A method for forming a nanostructure array and a field effect transistor device on a substrate are provided. The method for forming the nanostructure array includes: providing a template solution comprising template nanostructures; depositing at least one template nanostructure onto the substrate by contacting the template solution with the substrate; and forming on the substrate at least one fixation structure each intersecting with all or a portion of the at least one template nanostructure to fix all or a portion of the at least one template nanostructure on the substrate.
A sensor array device includes a substrate and electrodes. The electrodes include a power electrode located in a first region of the substrate and a plurality of working electrodes located in a second region of the substrate. Surfaces of the working electrodes have various specific enzymes, respectively, and the specific enzymes on the surfaces of the working electrodes are different. The plurality of working electrodes are located in different sub-regions of the second region, respectively. The sensor array device further includes a guide layer or a hydrophilic layer. The guide layer is located above the electrodes and covers the first region and the second region. An edge of the guide layer extends to an edge of the substrate. The hydrophilic layer is arranged on the substrate and covers the first region and the second region, and an edge of the hydrophilic layer extends to the edge of the substrate.
A processing method of a flexible hybrid electronic system is provided and includes the following steps: etching out embedded grooves on a front surface of a silicon-based substrate embedding a plurality of heterogeneous chips into corresponding embedded grooves, wherein front surfaces of the embedded chips are flush with the front surface of the silicon-based substrate; then gradually realize the polymer flexible connection, electrical interconnection, insulation protection, and polymer flexible coverage between chips. The processing method processes the flexible hybrid electronic system based on the method of embedding chips, which can reduce material loss and processing steps, and is beneficial to realizing large-scale manufacturing.
H01L 23/538 - Dispositions pour conduire le courant électrique à l'intérieur du dispositif pendant son fonctionnement, d'un composant à un autre la structure d'interconnexion entre une pluralité de puces semi-conductrices se trouvant au-dessus ou à l'intérieur de substrats isolants
H01L 21/56 - Capsulations, p.ex. couches de capsulation, revêtements
H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
H01L 21/48 - Fabrication ou traitement de parties, p.ex. de conteneurs, avant l'assemblage des dispositifs, en utilisant des procédés non couverts par l'un uniquement des groupes
48.
METHOD, SYSTEM, DEVICE AND STORAGE MEDIUM FOR NON-CONTACT VELOCITY ESTIMATION OF A MOVING TARGET
The present disclosure relates to a method, a system, a device and a storage medium for non-contact velocity estimation of a moving target. The method comprises the following steps: acquiring channel state information or other information that includes motion information of a moving target through at least two receiving devices, eliminating a random phase offset of the channel state information or other information to acquire newly constructed signals, and performing a denoising and filtering process on the newly constructed signals; identifying a motion state of the target according to the newly constructed signals, and dynamically selecting two optimal receiving devices if the target is moving; respectively extracting a Doppler frequency shift caused by the motion of the target from the two selected optimal receiving devices, and calculating a velocity of the moving target according to the Doppler frequency shifts.
G01S 13/58 - Systèmes de détermination de la vitesse ou de la trajectoire; Systèmes de détermination du sens d'un mouvement
G01S 7/28 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe - Détails des systèmes à impulsions
49.
METHOD FOR DEPOSITING NANOSTRUCTURES ON SUBSTRATE AND NANOSTRUCTURE ARRAYS
A method for depositing nanostructures on a substrate comprises: forming a patterned alignment layer on a surface of the substrate, wherein the patterned alignment layer has one or more cavities each having a main region for accommodating at least one template nanostructure therein and a plurality of extension regions extending from the main region and in fluid communication with the main region, and wherein the plurality of extension regions are sized and shaped to not accommodate the at least one template nanostructure; and diffusing template nanostructures into the one or more cavities of the patterned alignment layer.
A method for training a feature quantization model includes: obtaining a plurality of source data domains; obtaining feature information and labeling information of each of the plurality of source data domains; decomposing the feature information of each of the plurality of source data domains, so as to obtain common feature information and domain-specific feature information of the plurality of source data domains, the common feature information being feature information common to the plurality of source data domains; and training a feature quantization model according to the common feature information of all the source data domains, and domain-specific feature information and the labeling information of each of the plurality of source data domains, so as to obtain a common feature quantization model.
An image inpainting method includes: acquiring an image to be inpainted based on depth information and texture information of a reference image, the image to be inpainted including at least one region to be inpainted; determining at least one reference block matching the at least one region to be inpainted respectively in the reference image; and inpainting the at least one region to be inpainted by using the at least one reference block to obtain a composite image.
Disclosed are a method and an apparatus for designing a magnetic shielding apparatus and a magnetic shielding apparatus. The method includes: determining a region of interest inside the magnetic shielding apparatus, the region of interest being a region where a magnetic shielding effect is expected to be achieved, and the magnetic shielding apparatus including N layers of shields disposed in a nested manner; determining a complete parameter set; and obtaining, based on the complete parameter set, a set of result parameters for describing the geometric structure, the set of result parameters that enables magnetic flux density in the region of interest to meet a preset threshold. This method not only greatly improves optimized magnetic shielding performance compared with an equal-spacing solution, but also resolves a problem that an analytical method cannot be used to optimize a magnetic shielding apparatus with a non-concentric structure.
The present invention relates to a location-awareness-based network intermediate device, at least comprising a scheduling module, which is configured to fuse short-term historical data about short-term and/or real-time network performance and location-awareness-based multi-day network performance data, so as to generate context data for predicting network performance, and acquire a deterministic connectivity mode in a mobile network environment based on the context data so as to enhance performance of end-to-end transmission. With this configuration, the concept of location-awareness-based packet scheduling can be translated into an actual system for end-to-end multi-path transmission. From the location-awareness-based long-term multi-day network performance data, the deterministic connectivity pattern of trains in the high-speed mobile network environment can be acquired, and after being fused with the short-term historical data observed in a short time period, a good basis for calibration of prediction of network performance can be provided, thereby enhancing robustness of network connectivity in a high-speed movement scene.
H04W 40/18 - Sélection d'itinéraire ou de voie de communication, p.ex. routage basé sur l'énergie disponible ou le chemin le plus court sur la base des événements prévus
H04L 67/562 - Courtage des services de mandataires
H04L 41/147 - Analyse ou conception de réseau pour prédire le comportement du réseau
A pharmacological composition contains a complex having a structurally modified RGD polypeptide a radionuclide. This pharmacological composition is useful for diagnosis or treatment of the integrin αvβ3-positive tumors. The pharmacological composition may further contain an immunotherapeutic medicament and an optional nanoantibody molecular imaging probe. Treatment with a PD-L1 blockade after the targeted radioactive therapy can archive the optimal synergic efficacy. Moreover, with administration of PD-1 or PD-L1 nanoantibody molecular imaging probe, expression of PD-1 or PD-L1 in the tumor after targeted radiotherapy can be observed.
Provided are a monoclonal antibody against a novel coronavirus and a composition that comprises said antibody. The antibody can be used to diagnose, prevent and/or treat novel coronavirus infections and/or diseases caused by an infection.
C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61P 31/14 - Antiviraux pour le traitement des virus ARN
G01N 33/577 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des anticorps monoclonaux
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
56.
USE OF BILE ACIDS AND DERIVATIVES THEREOF IN PREPARATION OF GPR39 AGONIST
A use of the bile acids represented by Formula (1) and derivatives thereof in the preparation of a GPR39 agonist, as well as a drug composite which contains such bile acids and the derivatives thereof as the active ingredient, the drug composite being used to prevent, treat and/or relieve diseases associated with GPR39 activity.
A use of the bile acids represented by Formula (1) and derivatives thereof in the preparation of a GPR39 agonist, as well as a drug composite which contains such bile acids and the derivatives thereof as the active ingredient, the drug composite being used to prevent, treat and/or relieve diseases associated with GPR39 activity.
A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p.ex. cholane, cholestane, ergostérol, sitostérol
Provided is a preparation method for an ultrahigh-conductivity multilayer single-crystal laminated copper material, where multiple layers of single-crystal copper foils are laminated together to form a laminate, and the laminate is pressurized and annealed as one piece by performing pressurizing and high-temperature annealing at the same time, or the laminate is pressed as one piece by means of direct hot rolling, thereby obtaining an ultrahigh-conductivity multi-layer single-crystal laminated copper material, whereby, according to the method, multiple layers of single-crystal copper foils are used as raw materials, an ultrahigh-conductivity multi-layer single-crystal laminated copper material is prepared by means of hot rolling or pressing and annealing, and the conductivity of the copper material is greater than or equal to 105% IACS.
B32B 15/01 - Produits stratifiés composés essentiellement de métal toutes les couches étant composées exclusivement de métal
C22F 1/08 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du cuivre ou de ses alliages
B21B 3/00 - Laminage des matériaux faits d'alliages particuliers dans la mesure où la nature de l'alliage exige ou permet l'emploi de méthodes ou de séquences particulières
A microneedle biosensor includes a microneedle and a substrate. One end of the microneedle is connected to the substrate, an outer surface of the microneedle is provided with a working electrode and a first electrode, an outer surface of the working electrode is provided with an enzyme, and an outer surface of the microneedle biosensor is covered with a biocompatible film. A method for manufacturing a microneedle biosensor includes: manufacturing the substrate and the microneedle in an additive mode simultaneously; spray-printing and curing the working electrode and the first electrode on the outer surface of the microneedle; spray-printing and drying the enzyme on the outer surface of the working electrode; and using biocompatible liquid for spray-printing, and drying the biocompatible liquid to form the biocompatible film. The substrate, the microneedle, the working electrode, the first electrode, the enzyme and the biocompatible film are all manufactured through a full printing method.
The present disclosure relates to the technical field of microwave absorption, and in particular, to a multi-layer wave absorber structure and use thereof. The multi-layer wave absorber structure has a sandwich structure, and an intermediate layer of the sandwich structure is an electromagnetic loss-free dielectric layer. The electromagnetic loss-free dielectric layer includes a vacuum layer, an air layer, a paraffin layer, or a polytetrafluoroethylene layer. The added electromagnetic loss-free dielectric layer enhances impedance matching by modulating phases of electromagnetic waves, such that loss of the electromagnetic waves in a composite wave absorbing layer of the multi-layer wave absorber structure is enhanced, and an effective absorption bandwidth is further improved. The multi-layer wave absorber structure provided by the present disclosure has higher universality and operability, and has an effect of improving an effective absorption bandwidth for wave absorbing devices made of various composite wave absorbing materials.
H05K 9/00 - Blindage d'appareils ou de composants contre les champs électriques ou magnétiques
H01Q 17/00 - Dispositifs pour absorber les ondes rayonnées par une antenne; Combinaisons de tels dispositifs avec des éléments ou systèmes d'antennes actives
60.
METHOD FOR PREDICTING CELL SPATIAL RELATION BASED ON SINGLE-CELL TRANSCRIPTOME SEQUENCING DATA
A method for predicting the cell spatial relation based on single-cell transcriptome sequencing data includes the steps of obtaining a probability matrix P of a cell-cell interaction strength matrix A based on single-cell transcriptome sequencing data; reconstructing, according to the obtained probability matrix P of the cell-cell interaction strength matrix A, a three-dimensional spatial structure in which cells interact with each other; and for each cell in the reconstructed three-dimensional spatial structure in which cells interact with each other, determining the intercellular distance threshold for each cell to interact with h cells on average to obtain an intercellular interaction network. The method requires only the single-cell transcriptome sequencing data to predict the interaction of the cells in three-dimensional space, which breaks the limitation of the existing technology that needs to obtain the spatial relationship of cells through imaging.
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
Disclosed are a hypertext transfer protocol (HTTP) request transmission method and device. The HTTP request transmission method and device resolve a problem that data finally obtained through splicing is invalid because dividing an original HTTP request into a plurality of HTTP requests to pull data from different content distribution network (CDN) servers may cause inconsistency of the pulled data. When an electronic device needs to download data from a plurality of CDN servers, an overlapping range may be designed for byte ranges allocated to the different CDN servers. This means that the electronic device downloads data in the overlapping range from all the different CDN servers. Therefore, this part of data is used to check consistency of the data pulled from the different CDN servers. When determining that the data pulled from the different CDN servers is consistent, the electronic device may splice the data to obtain finally required data.
H04N 21/238 - Interfaçage de la voie descendante du réseau de transmission, p.ex. adaptation du débit de transmission d'un flux vidéo à la bande passante du réseau; Traitement de flux multiplexés
H04N 21/2665 - Rassemblement de contenus provenant de différentes sources, p.ex. Internet et satellite
H04N 21/41 - Structure de client; Structure de périphérique de client
H04N 21/4363 - Adaptation du flux vidéo à un réseau local spécifique, p.ex. un réseau IEEE 1394 ou Bluetooth®
H04N 21/61 - Structure physique de réseau; Traitement de signal
H04N 21/845 - Structuration du contenu, p.ex. décomposition du contenu en segments temporels
H04L 67/02 - Protocoles basés sur la technologie du Web, p.ex. protocole de transfert hypertexte [HTTP]
62.
Delta debugging method and system based on probability model
A delta debugging method and system based on a probability model which includes: acquiring an initial probability model and historical test data; optimizing and iterating the initial probability model through the historical test data to obtain an optimized and iterated probability model; and performing delta debugging on a target program containing multiple lines of code based on the optimized and iterated probability model to obtain a debugging result that meets a first preset condition. Therefore, by adopting the embodiment of the present application, the initial probability model can be continuously optimized and iterated through the historical test data, and the target program can be debugged based on the optimized and iterated probability model, so that the debugging result can be improved, or the compression amount of the size of the target program can reach a target compression amount, or the debugging time can be greatly reduced.
Disclosed are an electronic apparatus, and a method for displaying an image on a display device. The electronic apparatus comprises: a display device; an image acquisition device, which is configured to acquire a surrounding image of the display device; and a processor, which is configured to determine a background image of the display device according to the surrounding image, acquire a target range, and a target object in the background image, determine a target image according to the background image, the target range and the target object, and control the display device to display the target image, wherein the target image does not include the target object.
G06F 3/14 - Sortie numérique vers un dispositif de visualisation
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
G06V 40/10 - Corps d’êtres humains ou d’animaux, p.ex. occupants de véhicules automobiles ou piétons; Parties du corps, p.ex. mains
G06T 7/194 - Découpage; Détection de bords impliquant une segmentation premier plan-arrière-plan
G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
G06T 3/40 - Changement d'échelle d'une image entière ou d'une partie d'image
G09G 3/00 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques
64.
SPIKING CONVOLUTIONAL NEURAL NETWORK BASED ON FLASH STORAGE AND COMPUTING ARRAY
A spiking convolutional neural network based on a FLASH storage and computing array, including: a sampling module, a FLASH-based storage and computing array and a corresponding neuron module, and a counter module; the sampling module is used to sample an input image to obtain an input spike; the FLASH-based storage and computing array stores a weight matrix, and is used to perform a vector matrix multiplying operation on the input spike and the weight matrix, and an operation result is output in a form of current; the neuron module is used to integrate the operation result of the FLASH-based storage and computing array so as to generate an output spike; the counter module is used to count a number of spikes generated by the neuron module of an output layer, and determine the number of spikes of the neuron module with a largest number of spikes as a recognition result.
The present disclosure discloses a defect location method and device based on coverage information, the method including: characterizing program structure information and test case coverage information of a target program in a graph to obtain a graph-characterized structure; generating a node attribute sequence and an adjacency matrix based on the graph-characterized structure; and inputting the node attribute sequence and the adjacency matrix to a trained graph neural network model, so that the graph neural network model outputs a suspicious degree list of the target program based on the node attribute sequence and the adjacency matrix. Through the graph-based unified information characterization, the coverage information can be saved without loss and compression, and the structure information may also be considered, thereby improving the accuracy of defect location.
A human-cyber-physical resource-oriented adaptive construction method and apparatus for a structured peer-to-peer (P2P) network are provided. The structured P2P network is a point-to-point network with physical perception information and can be effectively used in a human-cyber-physical fusion scenario. The method includes: using a grid aggregation algorithm to calculate the latitude and longitude coordinates of a new node to acquire a position hash value of the new node; determining, according to the position hash value, a registration node of the new node from the existing nodes of the structured P2P network; and completing, according to the information returned by the registration node to the new node, registration of the new node, thereby resulting adding of the registered new node into the structured P2P network.
G06F 15/16 - Associations de plusieurs calculateurs numériques comportant chacun au moins une unité arithmétique, une unité programme et un registre, p.ex. pour le traitement simultané de plusieurs programmes
Senolytic and anti-inflammatory prodrugs are provided, which are designed from a cytotoxic agent, by chemically modifying the cytotoxic agent to incorporate a site cleavable by SA-β-gal following delivery of the prodrug in vivo, to release the active parent drug. The prodrug includes a galactose-based moiety, which is preferably acetylated, and benzyl oxy carboxy group and a cytotoxic agent moiety. The selenolytic prodrug is used to selectively kill one or more senescent cells and/or reduce an acute or chronic inflammatory response in a subject in need thereof, by administering to the subject therapeutically effective amount of the senolytic prodrugs. The disclosed compositions can be used to reduce one or more symptoms associated with a Senescence-associated disease or disorder or an inflammatory disorder, for example, a virus-mediated inflammation, in a subject.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p.ex. cytidine, acide cytidylique
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
68.
Method and system for accessing digital object in human-cyber-physical environment
A method and system for accessing a digital object in a Human-Cyber-Physical environment are provided. A P2P network is established based on a distributed hash table (DHT); a Kademlia algorithm is used to establish a forward routing table corresponding to each node; and an index binary tree is established according to a logical distance between each node in the forward routing table and a target node. In a process of transmitting a message from a node of a storage digital object to a root node, all nodes that the message passes establish backward routing tables for the digital object, so that in a data query stage, target data may be found from any node through the forward routing table and the backward routing table, and a data identifier of a data entity in the DHT-based P2P network from a storage location of the data identifier may be decoupled.
H04L 67/1061 - Réseaux de pairs [P2P] en utilisant des mécanismes de découverte de pairs basés sur les nœuds
H04L 45/02 - Mise à jour ou découverte de topologie
H04L 67/1095 - Réplication ou mise en miroir des données, p.ex. l’ordonnancement ou le transport pour la synchronisation des données entre les nœuds du réseau
69.
PIXEL UNIT AND SIGNAL PROCESSING METHOD FOR PIXEL UNIT
The present application discloses a pixel unit and a signal processing method for a pixel unit. The pixel unit includes at least one pixel, and the pixel includes: an N-type main pixel, a P-type main pixel, and a sub-pixel; and the sub-pixel is located between the N-type main pixel and the P-type main pixel; or the pixel includes at least a first pixel and a second pixel that are adjacent to each other; the first pixel includes an N-type main pixel, and the second pixel includes a P-type main pixel; the first pixel and the second pixel share one sub-pixel; the sub-pixel is configured to generate and output a signal difference between the N-type main pixel and the P-type main pixel according to the current. By adding a sub-pixel between two main pixels, the sub-pixel generates and outputs the signal difference between the N-type main pixel and the P-type main pixel according to the current sent by the two main pixels, so that the received signal can be efficiently processed directly to reduce the amount of output data. Since there is no need to increase a circuit, the pixel area will not increase due to a complicated circuit.
H04N 5/3745 - Capteurs adressés, p.ex. capteurs MOS ou CMOS ayant des composants supplémentaires incorporés au sein d'un pixel ou connectés à un groupe de pixels au sein d'une matrice de capteurs, p.ex. mémoires, convertisseurs A/N, amplificateurs de pixels, circuits communs ou composants communs
H04N 5/369 - Transformation d'informations lumineuses ou analogues en informations électriques utilisant des capteurs d'images à l'état solide [capteurs SSIS] circuits associés à cette dernière
A topological bulk laser includes a topological photonic crystal (32) having an energy band inversion between dipole mode and quadrupole mode near the center of Brillouin zone and a trivial photonic crystal (31) not having band inversion for splicing to each other. The reflection and confinement of an optical field occurs at the interface; and the interface encloses to form a closed contour, thereby forming a laser cavity with an effective cavity feedback for lasing at the interior of the interface. This band-inversion-induced reflection mechanism induces single-mode lasing with directional vertical emission. At room temperature, the topological bulk laser can achieve low threshold, narrow linewidth, and a high side-mode suppression ratio, reduce the fabrication difficulty and costs, and improve heat dissipation and electrical injection efficiency, hence improving lifetime and stability of devices.
Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5′-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.
A deep neural network based on analog FLASH computing array, includes a number of computing arrays, a number of subtractors, a number of activation circuit units and a number of integral-recognition circuit units. The computing array includes a number of computing units, a number of word lines, a plurality number of bit lines and a number of source lines. Each of the computing units includes a FLASH cell. The gate electrodes of the FLASH cells in the same column are connected to the same word line. The source electrodes of the FLASH cells in the same column are connected to the same source line, and the drain electrodes of the FLASH cells in the same row are connected to the same bit line. Each of the subtractors includes a positive terminal, a negative terminal and an output terminal.
G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
A system and a method for compressing an image based on a FLASH in-memory computing array are provided. The system includes: a convolutional neural network for encoding of the FLASH in-memory computing array, a convolutional neural network for decoding based on the FLASH in-memory computing array, and a quantization module; the convolutional neural network for encoding based on the FLASH in-memory computing array is configured to encode an original image to obtain a feature image; the quantization module is configured to quantize the feature image to obtain a quantized image; the convolutional neural network for decoding based on the FLASH in-memory computing array is configured to decode the quantized image to obtain a compressed image.
H04N 19/423 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques - caractérisés par les détails de mise en œuvre ou le matériel spécialement adapté à la compression ou à la décompression vidéo, p.ex. la mise en œuvre de logiciels spécialisés caractérisés par les dispositions des mémoires
H04N 19/127 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’élément, le paramètre ou la sélection affectés ou contrôlés par le codage adaptatif Établissement des priorités des ressources en matériel ou en calcul
74.
METHOD FOR MULTIPLEXING HTTP CHANNELS AND TERMINAL
This application provides a method for multiplexing HTTP channels. The method includes: sending, by the terminal, a first HTTP request to a first server through a first HTTP channel, to request first data; after receiving a first HTTP response returned by the first server, receiving, through the first HTTP channel, a first part that is of the first data and that is sent by the first server; and if a size that is of the first data and that is carried in the first HTTP response is greater than a first threshold, generating a second HTTP request, and sending a second HTTP request to a second server through a second HTTP channel, to request a second part of the first data; and after receiving the first part of the first data, sending control signaling to the first server, to disconnect the first HTTP channel.
Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
The present disclosure discloses a conflict detection method for Internet of Things (IoT) device scheduling, relating to the technical field of the IoT, and specific steps include: acquiring data of a device model; converting a device scheduling instruction into a conditional instruction according to the data of the device model; determining a scheduling conflict rule according to device scheduling conflicts in historical data; detecting whether the conditional instruction is in a conflict state based on the scheduling conflict rule; if the conditional instruction is in a conflict state, performing a first conflict resolution, or if the conditional instruction is in a non-conflict state or after a conflict is resolved, performing a second detection; converting, in the second detection, the conditional instruction into an SMT formula, inputting the SMT formula into an SMT solver for detection, and determining whether the conditional instruction is in a conflict state; and if the conditional instruction is in a conflict state, performing second conflict resolution, or if the conditional instruction is in a non-conflict state or after a conflict is resolved, executing the conditional instruction. The present disclosure ensures consistency between different services of the IoT, and a rule-based method and an SMT solver-based method are adopted to perform conflict detection.
An image processing method and apparatus, and a device and a computer-readable storage medium. The method comprises: acquiring an image data set, wherein the image data set includes an image and accompanying text related to an unknown category in the image (S101); and generating a probability and/or distribution of the unknown category by means of an unknown category acquisition model (S102); wherein the probability and/or distribution of the unknown category comprises the probability of each pixel in the image being from the unknown category, the probability of the unknown category being present in the image, and a partitioning probability after the image is subdivided into a plurality of areas. By means of the method, a large amount of human labor costs and time can be saved on.
G06V 10/26 - Segmentation de formes dans le champ d’image; Découpage ou fusion d’éléments d’image visant à établir la région de motif, p.ex. techniques de regroupement; Détection d’occlusion
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p.ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersections; Analyse de connectivité, p.ex. de composantes connectées
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
G06N 7/00 - Agencements informatiques fondés sur des modèles mathématiques spécifiques
78.
Method for characterizing fluctuation induced by single particle irradiation in a device and application thereof
A method for characterizing a fluctuation induced by single particle irradiation in a device. A plurality of devices varying in size are tested respectively before and after irradiation to obtain threshold voltage distribution, such that a threshold voltage fluctuation induced by irradiation is obtained and used to correct a process fluctuation model, so as to correct a design margin of the devices working under the irradiation.
G01R 31/28 - Test de circuits électroniques, p.ex. à l'aide d'un traceur de signaux
G06F 30/367 - Vérification de la conception, p.ex. par simulation, programme de simulation avec emphase de circuit intégré [SPICE], méthodes directes ou de relaxation
G06F 119/02 - Analyse de fiabilité ou optimisation de fiabilité; Analyse de défaillance, p.ex. performance dans le pire scénario, analyse du mode de défaillance et de ses effets [FMEA]
79.
METHOD FOR QUASI-SYNCHRONOUS CODE DIVISION MULTIPLE ACCESS BASED ON SYNCHRONIZATION CLOCK BY PILOTING
A method for quasi-synchronous code division multiple access based on synchronization clock by piloting can make CDMA operate in quasi-synchronous conditions, so it is suitable for open wireless channels with relay nodes, such as satellite communication systems, and open wireless channels without relay nodes. The method includes: adopting a mode of CDMA spread spectrum transmission to share power resources to transmit signals at multiple transmitting stations in open wireless channels; adopting an external pilot signal to provide synchronization clock for the CDMA signals transmitted by multiple terminal stations in the open wireless channels, eliminating path delay differences from the multiple terminal stations to a relay node or receiving station, and making multi-channel CDMA signals received at the relay node or receiving station clock synchronized and phase aligned. The method can realize the quasi-synchronous reception of multi-channel CDMA signals.
H04B 7/06 - Systèmes de diversité; Systèmes à plusieurs antennes, c. à d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission
80.
RESISTIVE RANDOM ACCESS MEMORY OPERATION CIRCUIT AND OPERATION METHOD
An operating circuit and an operating method of a resistive random-access memory are provided, the operating circuit includes: at least one capacitance connected in series with the resistive random-access memory, so that the resistive random-access memory is grounded through the at least one capacitance. The operating method includes: connecting at least one capacitance in series with a resistive random-access memory, so that the resistive random-access memory is grounded through the capacitance; applying a forming pulse voltage or a set pulse voltage on the resistive random-access memory to achieve a forming operation or a set operation of the resistive random-access memory.
A method for allocating resource and accessing in open wireless channels includes: covering multiple types of user terminal stations in open wireless channels; making dynamic adaptive matching according to comprehensive change factors of a transmitting end and a receiving end in each communication process. The factors of the transmitting end mean that a type and transmitting capacity of a transmitting station are changed, a current state of the wireless channel between the transmitting station and a relay node is changed, a working state of a receiving end of the relay node is changed, and user services to be transmitted are changed; the factors of the receiving end mean that a type and receiving capacity of a receiving station are changed, a current state of the channel from the relay node to the receiving station is changed, and a working state of a transmitting end of the relay node is changed.
A microfluidic chip capable of being used for capturing target particles, the chip comprising a convergence and shunt unit, the convergence and shunt unit being capable of converging target particles in a liquid sample to the centre of a liquid flow, and simultaneously splitting off a certain proportion of the liquid flow that does not contain target particles, thereby effectively reducing the flow and speed of the liquid flow inputted to the chip; when used for capturing target particles, the chip also comprises a capturing unit, and implements capture of the target particles by means of the capturing unit.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
The present application discloses a UTBB photodetector pixel unit, array and method, including: a silicon film layer, a buried oxide layer, a charge collection layer and a substrate, the silicon film layer, the buried oxide layer, the charge collection layer and the substrate being arranged in sequence from top to bottom; the silicon film layer includes NMOS transistors or PMOS transistors; the charge collection layer includes charge collection control regions and charge accumulation regions; and the substrate includes an N-type substrate or a P-type substrate. A centripetal electric field is formed around the charge accumulation regions, and photo-generated charges are accumulated in the corresponding pixel units under the action of the centripetal electric field. The existence of the centripetal electric field improves the photoelectric conversion efficiency, suppresses the crosstalk between pixels, saves the area of shallow trench isolation, reduces the size, and makes it more suitable for sub-micron pixels.
Provided are methods of treating or preventing Ca2+/calmodulin-dependent kinase II (CaMKII)-mediated diseases, methods of alleviating cardiac injury, methods of stimulating the activity of ubiquitin-conjugating enzyme, methods of preventing degradation of ubiquitin-conjugating enzyme, methods of preventing cardiomyocyte death, methods of reducing DNA damage in a cell, methods for diagnosing CaMKII-mediated diseases, kits for diagnosing CaMKII-mediated diseases, biomarkers for diagnosing a CaMKII-mediated disease, and use of CaMKIIδ9 as a biomarker for diagnosing a CaMKII-mediated disease. Also provided herein are methods for identifying molecules, isolated polypeptides, isolated nucleic acids, and antagonists thereof.
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une transférase
85.
TARGETED RNA EDITING BY LEVERAGING ENDOGENOUS ADAR USING ENGINEERED RNAS
Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
A method for piloting from bypass in a network with open wireless channels is disclosed. The method includes: 1) selecting a terminal station as a reference in open wireless channels, and sending a pilot signal, in which all or some frequency bands of open wireless channels occupied by the pilot signal are pilot frequency bands, and the proportion of power of the pilot signal to the total power of the pilot frequency bands is 0.1‰-5%; 2) spreading the pilot signal with a spread spectrum code when it is transmitted, and then superimposing on a communication signal in the pilot frequency bands in a low power spectrum signal mode similar with noise; and 3) providing pilot, carrier wave and clock synchronization, standard timing and indication information for network construction and mutual communication of multiple types of terminal stations in channels by the pilot signal.
A method for piloting from bypass in a network based on a satellite load platform can unify the influence of distance change and Doppler frequency shift of satellite ground stations in the whole network, and realize accurate quasi synchronization between the clock of the whole network and the clock of the satellite. The method includes transmitting a pilot signal from bypass based on a satellite load platform in a satellite communication system, taking a spaceborne high stability timing clock source as a reference, and transmitting the pilot signal to all downlink beams to provide the pilot signal for all satellite stations covered by the satellite.
A method for processing time series data comprises: dividing time series data into a plurality of data fragments according to an objective function, the plurality of data fragments having a greatest similarity; in response to determining that at least one data fragment does not satisfy an iteration termination condition, performing following iteration operations on the at least one data fragment; and constructing a time series base pattern library by using a plurality of time series base patterns. The iteration operations includes: using the at least one data fragment as at least one update time series fragment; dividing each update time series fragment into a plurality of update data fragments; using each update data fragment that does not satisfy the iteration termination condition as a new update time series fragment; and using each update data fragment that satisfies the iteration termination condition as a time series base pattern.
Provided is a method for detecting the chemical modification of a target RNA site X, comprising the steps as follows: (1) acquiring an RNA sample and selecting in the RNA sample a target RNA segment comprising the target RNA site X; (2) SELECT; (3) PCR amplification; (4) comprising the PCR cycle threshold value with a reference PCR cycle threshold value, or comparing the PCR amplification product quantity with a reference PCR amplification product quantity, so as to determine whether there is a target chemical modification in the target RNA site X. Further provided are a method for identifying a substrate target site of RNA modification enzyme or RNA demodification enzyme and a method for quantifying an RNA modification rate in a transcript.
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une oxydoréductase
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une transférase
90.
ELECTRICAL CONDUCTORS AND METHODS OF CONDUCTING IONS USING CALSEQUESTRIN PROTEINS
An in vitro electrical conductor is provided. The in vitro electrical conductor may include a plurality of Calsequestrin (CSQ) protein molecules. The CSQ protein molecules may be connected to form a tendril, a network structure, or a biological tunnel structure. An electrical device including the in vitro electrical conductor is provided. An ionic transistor including the in vitro electrical conductor is provided. An in vitro method of conducting ions from an ion source to an ion sink is further provided. The method may include providing an electrical conductor including a plurality of CSQ protein molecules and conducting ions through the electrical conductor to the ion sink. The CSQ protein molecules may be connected to form a tendril, a network structure, or a biological tunnel structure.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C08L 89/00 - Compositions contenant des protéines; Compositions contenant leurs dérivés
G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
An immune enhancement composition and a vaccine composition comprising newly precipitated manganese and/or colloid manganese, a preparation method therefor, and use thereof for immunization and/or vaccination enhancement.
Institute of Biophysics, Chinese Academy of Sciences (Chine)
Institute of Laboratory Animal Science, Chinese Academy of Medical Science (Chine)
Inventeur(s)
You, Fuping
Wang, Xiangxi
Qin, Chuan
Abrégé
The present disclosure relates to a method for preventing and treating or diagnosing coronavirus infection. SARS-CoV2 lung infection animal models are established using rhesus macaques and human ACE2 transgenic mice, innate immune characteristics that occur in the body in the early stage of SARS-CoV2 infection are explored, and S100A8 protein is found as the root cause initiating the inflammatory storm and becomes an immune indicator for early diagnosis of a patient with SARS-CoV2 infection. Then inhibition of the function of S100A8/S100A9 dimer finally inhibits the virus titer in tissues, thereby decreasing the inflammation level, which proves that a dimer inhibitor can be used as an effective drug for preventing and treating coronavirus infection.
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61P 31/14 - Antiviraux pour le traitement des virus ARN
This application provides a data transmission method. The method includes: An electronic device first establishes an MPTCP connection to an application server, where the MPTCP connection includes two TCP connections. Then, the electronic device receives indication information from an application server, where the indication information includes a type identifier and a parameter. When the type identifier indicates a low data transmission delay requirement, the electronic device receives, in a first time period after the electronic device receives the indication information, the data stream by using a first TCP connection. When an accumulated data amount actually received by the electronic device in the first time period is less than a product of the parameter and duration corresponding to the first time period, the electronic device receives the data stream in a second time period by using both the two TCP connections.
This application relates to an image recognition technology in the artificial intelligence field, and provides an image classification method and apparatus, and an image classification model training method and apparatus. This application relates to the artificial intelligence field, and more specifically, to the computer vision field. The method includes: obtaining a to-be-processed image; and classifying the to-be-processed image based on a preset global class feature, to obtain a classification result of the to-be-processed image. The global class feature includes a plurality of class features obtained through training based on a plurality of training images in a training set. The plurality of class features in the global class feature are used to indicate visual features of all classes in the training set.
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
A method for clonal-growth of a single-crystal metal, including: using copper as an example, placing an existing small-sized single-crystal copper foil with a plane of any index on a copper foil that needs to be single-crystallized, and performing annealing to obtain, by cloning, a large-area (in meters) single-crystal copper foil with the same surface index as that of the parent facet. The method solves the difficult problem of large-area single-crystal copper foil preparation. By performing annealing, a parent single-crystal copper foil with a very small size (˜0.25 cm2) can be cloned to produce a large-area (˜700 cm2) single-crystal copper foil, which is an increase in area of about 3000 times.
Provided are compositions for long-term maintenance of functional hepatocytes in culture, a method for improved maintenance of functional hepatocytes in vitro, and functional hepatocytes cultures according to the methods. The culture compositions include at least: one activator of adenylate cyclase, one TGFβ inhibitor, one Notch inhibitor, one Wnt inhibitor, and/or one BMP inhibitor. The combinations of compounds are added to any hepatocyte cell culture medium in an effective amount to maintain functional hepatocyte function in vitro, long term. The hepatocytes can be used for in vitro drug research and to model liver disease.
A method for inducing non-hepatocytes into hepatocyte-like cells, wherein the non-hepatocytes are induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte expansion culture medium and 2C medium for a sufficient period of time to convert the non-hepatocyte cell into cells with hepatocyte-like properties, are provided. The iHeps induced according to the methods are also provided.
C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
99.
METHOD FOR RECONSTRUCTING COMPLEX BIOLOGICAL SYSTEM ON THE BASIS OF POLYPROTEIN, AND USE THEREOF IN HIGH ACTIVITY SUPER SIMPLIFIED NITROGEN FIXATION SYSTEM CONSTRUCTION
An expression method, a vector and a vector composition are provided. In particular, a method for exogenously expressing a complex biological system in host cells, as well as a vector and a vector composition for the method are provided.
C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
brevets
