A data processing method, applied to adversarial training of a model. The method comprises: acquiring a first disturbance, wherein the rank of the first disturbance is less than the rank of training data, and the first disturbance is fused with the training data to obtain first data; and according to the first data, obtaining a loss by means of a machine learning model, wherein the loss is used for updating the first disturbance to obtain a second disturbance, the second disturbance is fused with the training data to obtain second data, and the second data is used for updating the machine learning model. According to the present application, a low-rank structure is introduced into a disturbance, such that low-rank false information (or can be called false features) can be better captured and filtered out, and a disturbance can be effectively applied to false features in a training sample, such that the robustness of a trained model to the false features in data can be improved, and then good OOD performance is achieved.
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
2.
METHODS FOR CHEMICAL REPROGRAMMING AND PLURIPOTENT STEM CELLS
Provided herein, in some aspects, are methods and compositions for cell conversion. The methods may convert a cell population comprising one cell type to another cell population comprising another cell type. The converted cell types may have increased cell differentiation potential. The converted cell types can comprise pluripotent stem cells. The compositions provided herein may comprise chemical reprogramming factors for converting cells. The compositions provided herein may comprise chemical reprogramming factors and cells. Also provided herein are reagents for carrying out the methods for converting cells. Additionally, provided herein are methods and compositions for using various cell types obtained by the methods and/or compositions provided herein.
Disclosed in the present invention are an inverse halftoning method and apparatus based on a conditional diffusion network. The method comprises: calculating an image grayscale level and Laplacian prior of a halftone image; under the image grayscale level and the Laplacian prior, performing reverse dithering diffusion for T time steps on at least one initial state (aa), so as to generate a halftone distribution; and under the halftone distribution, performing inverse halftoning diffusion for T' time steps on at least one initial state (bb), so as to obtain an inverse halftoning result of the halftone image. By means of the present invention, the inpainting quality of a print is improved.
The present invention belongs to the technical field of oligosaccharides and glycoconjugates thereof, and specifically relates to a sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, a glycoconjugate and a preparation method therefor. Provided are a nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, which has a structure as shown in formula 1. Experiments in mice show that the nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof can be coupled with a carrier protein or a polypeptide via different linkers to obtain a glycoprotein (glycopeptide) conjugate, which generates a more effective immune response, and can specifically recognize tumor cells expressing STn, thereby achieving an anti-tumor effect. The present invention provides a new skeleton structure for the research on and development of anti-tumor carbohydrate vaccines, and is expected to promote the development of anti-tumor carbohydrate vaccines.
C07K 14/34 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/385 - Haptens or antigens, bound to carriers
It relates to immune cells (e.g., T cells such as CAR-T cells, NK cells such as CAR-NK cells) modified to have no or reduced expression and/or function of one or more target proteins selected from the group consisting of: Signal Peptide Peptidase Like 3 (SPPL3), FADD, FAS, CASP8, ARID1A, BAK1, BID, ETS1, IKZF2, and HIST1H1B (such as SPPL3), uses thereof, and methods for generating thereof. Also provided are uses of the one or more target proteins (e.g., SPPL3) as a biomarker.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 35/04 - Antineoplastic agents specific for metastasis
Provided herein, in some aspects, are methods and compositions for cell conversion. The methods may convert a cell population comprising one cell type to another cell population comprising another cell type. The converted cell types may have increased cell differentiation potential. The converted cell types can comprise pluripotent stem cells. The compositions provided herein may comprise chemical reprogramming factors for converting cells. The compositions provided herein may comprise chemical reprogramming factors and cells. Also provided herein are reagents for carrying out the methods for converting cells. Additionally, provided herein are methods and compositions for using various cell types obtained by the methods and/or compositions provided herein.
A device and method for preparing a thermosetting bonded magnet are provided, the device includes a compressed air glue feeding tank and a composite-function mold. A feeding end of the compressed air glue feeding tank is connected to the composite-function mold. The composite-function mold includes a housing, the housing is disposed at an upper end and a lower end of the composite-function mold, and the housing includes a polytetrafluoroethylene upper cover and a polytetrafluoroethylene lower cover; the polytetrafluoroethylene upper cover and the polytetrafluoroethylene lower cover are respectively disposed at the upper end and the lower end of composite-function mold. The method uses a silica gel material as a binder for anisotropic magnets, and the selected raw materials and process are suitable for quickly obtaining a uniform magnet slurry. The curing process is controllable, and there is no organic solvent or heating during the mixing process.
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
8.
IMAGE PROCESSING MODEL TRAINING METHOD AND APPARATUS, IMAGE PROCESSING METHOD AND APPARATUS, AND DEVICE AND MEDIUM
An image processing model training method and apparatus, an image processing method and apparatus, and a device and a medium, which belong to the technical field of computer vision. The image processing model training method comprises: acquiring a sample image (401); inputting the sample image into a teacher image processing model to acquire a first image feature (402); inputting the sample image into a student image processing model to acquire a second image feature, and aligning the second image feature with the first image feature to obtain an aligned image feature (403); by using a first feature transformation model, transforming the aligned image feature to obtain a third image feature (404); on the basis of the difference between the first image feature and the third image feature, acquiring a feature difference loss, and acquiring a training loss on the basis of the feature difference loss (405); and by using the training loss, updating a parameter of the student image processing model to obtain a target image processing model (406).
G06V 10/77 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06N 3/04 - Architecture, e.g. interconnection topology
Methods are provided for determining a transcription factor binding site on genomic double stranded (ds) DNA of a eukaryotic cell or cells by contacting the genomic dsDNA with a dsDNA deaminase under conditions to convert cytosine of the genomic dsDNA to uracil, thereby creating treated genomic dsDNA, and identifying unconverted cytosine on the treated genomic dsDNA as a transcription factor binding site.
C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
10.
HIGH-AFFINITY PD1 PROTEIN CONJUGATE AND USE THEREOF
Provided is a high-affinity PD1 protein conjugate, which comprises an elastin-like polypeptide and a high-affinity PD1 protein connected to the elastin-like polypeptide. The conjugate significantly improves the biological half-life and bioavailability of the high-affinity PD1 protein and has tumor targeting and permeability and tumor microenvironment temperature responsiveness.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A natural gas separation and purification and mercury collection system for oil and gas wells includes a cyclone separator, a condensation purification and separation mechanism, pressure buffer mechanisms, mercury collection and separation mechanisms, and natural gas storage tanks. An inlet end of the cyclone separator is communicated with an external gas source through a pressure buffer mechanism, and an outlet end of the cyclone separator is communicated with the condensation purification and separation mechanism through a pressure buffer mechanism. The condensation purification and separation mechanism is communicated with the mercury collection and separation mechanism through a pressure buffer mechanism. The mercury collection and separation mechanism is communicated with the natural gas storage tank through a guide tube. A method of use of the natural gas separation and purification and mercury collection system includes gas collection, gas purification, mercury separation, and mercury analysis.
B01D 45/16 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces generated by the winding course of the gas stream
B01D 53/00 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
B01D 53/30 - Controlling by gas-analysis apparatus
C10L 3/10 - Working-up natural gas or synthetic natural gas
13.
METHOD FOR REALIZING CONTENT-ADDRESSABLE MEMORY BASED ON FIELD EFFECT TRANSISTORS HAVING BIPOLAR CHARACTERISTICS
A method of realizing a content-addressable memory (CAM) based on field effect transistors having bipolar characteristics. By inserting a storage layer between a gate dielectric layer and a control gate of a field effect transistor having a bipolar characteristic and a source-drain symmetry, the threshold voltage is adjusted for information storage; further, a non-monotonic transfer characteristic of said field effect transistor is used for an input search, thus implementing a linearly inseparable comparison operation required by a CAM unit on a single field effect transistor having a bipolar characteristic adjustable threshold. Compared with the CAM designs based on traditional MOSFETs, the present invention has remarkably reduced unit area and a simpler programming and search operation process, accordingly realizing higher energy efficiency and extra wide application space.
G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using ferroelectric elements
G11C 5/06 - Arrangements for interconnecting storage elements electrically, e.g. by wiring
14.
ADIPOSE TISSUE ADHESIVE FOR REPLACING ABSORBABLE SUTURE, PREPARATION METHOD, AND USE THEREOF
The present disclosure provides an adipose tissue adhesive for replacing an absorbable suture, a preparation method, and use thereof, and belongs to the technical field of hydrogel adhesives. The adipose tissue adhesive comprises a natural polymer, a cross-linking agent, and a topological small molecule. Using the natural polymer as a main network, the adipose tissue adhesive is formed by means of physical crosslinking. By means of the present disclosure, high-strength adhesion to a subcutaneous adipose tissue can be realized with a strength of up to 100 kPa, and it is expected to replace an absorbable suture for subcutaneous adipose closure, thereby solving the problem that it is difficult for a biological adhesive to adhere to a grease tissue. Different from existing adhesion means, an adhesion interface formed by the hydrogel can be gradually strengthened over time, and can maintain the stability and effectiveness of wound closure in a hypersaline environment or under the change of a physiological pH value. The hydrogel is easy to operate, and can be injected into affected parts of various shapes to realize instantaneous closure, thereby further improving the efficiency of wound treatment in first aid, reducing the cost of surgery and the degree of wound infection, and having clinical popularization value.
BEIJING BIOTUNE MEDICAL TECHNOLOGY CO., LTD (China)
PEKING UNIVERSITY (China)
Inventor
Guo, Yuxuan
Chen, Zhan
Abstract
Disclosed are a nucleic acid molecule comprising an alternative splicing regulatory element and a target gene located at the 3' terminus of the alternative splicing regulatory element, a transcript of the nucleic acid molecule, a vector comprising the nucleic acid molecule or the transcript, a recombinant virus, a cell, a pharmaceutical composition, a method for using the same in regulating the expression level of the target gene, and use thereof in gene therapy.
A flexible permanent magnetic material, a preparation method and an application thereof in magnetic biological effect products are provides, relating to the technical field of medical equipment. Raw materials of the flexible permanent magnetic material of the application include the following components in parts by weight: 0-70 parts of anisotropic neodymium iron boron powder and 0-40 parts of anisotropic samarium iron nitrogen powder and 3-20 parts of binder.
H01F 1/057 - Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5 and IIIa elements, e.g. Nd2Fe14B
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor
B22F 3/087 - Compacting only using high energy impulses, e.g. magnetic field impulses
H01F 41/00 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties
17.
PROCESS FOR PREPARING CARBOXYL CYCLIC ACID ANHYDRIDE
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. The disclosed method includes the steps of reacting a compound of formula (I) with a cyclization reagent to produce the compound of formula (II) and an acid, and using an epoxy compound as an acid scavenger. The disclosed method is low in cost, and has low requirements for reagents, places and equipment required for experiments, mild conditions, a wide application range of substrates and a high tolerance of functional groups. The synthesis route can recycle some solvents and other high value-added by-products, with less waste liquid discharge and easy amplification. It also has extremely high industrial and academic value, and can greatly promote the rapid mass production and application of products such as polyamino acid, polyhydroxy acid (polyester), and polymercaptic acid (polysulfide).
An unsupervised low-illumination-domain adaptive training method and a detection method. The detection method comprises: 1) collecting labeled normal illumination training data, unlabeled low illumination training data and a pre-training model, and connecting a multi-layer perceptron behind a feature extractor of the pre-training model to obtain a first model; 2) training the multi-layer perceptron in the first model by using the normal illumination data; 3) constructing a depth concave curve model, and placing the depth concave curve model in front of a feature extractor in the first model to obtain a second model; 4) training the depth concave curve model in the second model by using the low illumination data; 5) brightening the low illumination data by using the depth concave curve model, inputting the low illumination data into the pre-training model, and taking the predicted label as a pseudo label of the low illumination data; 6) performing training and fine-tuning on the pre-training model by using the normal illumination data and the low illumination data with the pseudo label; and 7) brightening a low illumination image to be processed, inputting the brightened low illumination image to the fine-tuned pre-training model, and outputting a corresponding detection result.
The present disclosure provides a method for improving stability of an electrochemical sensor. The method includes the following steps: S1, manufacturing an electrochemical sensor; S2, immobilizing a biosensitive molecular enzyme on a working electrode of the electrochemical sensor; S3, setting a immobilization agent on a surface of the biosensitive molecular enzyme; and S4, adding a protective film on a surface of the immobilization agent, such that the protective film is deposited on the working electrode to improve the stability of the electrochemical sensor. In the present disclosure, glutaraldehyde (GA), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), or polyaniline (PANI), the GA, the PVA, the PEG, and polyurethane (PU) are arranged on a surface of the biosensitive molecular enzyme. Therefore, the surface of the biosensitive molecular enzyme forms a composite protective film, which reduces a probability of direct exposure of an enzyme layer to the air.
C08L 79/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups
A digital printing device calibration method, comprising: loading the current calibration function to output test data under specific output conditions; measuring a color value of each output color block in a device-independent color space by using a measurement device; calculating the color difference between adjacent color blocks of each colorant; and regenerating a new calibration function. By using the method, the calibration of any colorant can be realized, and the actual imaging effect of an individual colorant is visually approximately uniform.
An in-situ infrared dynamic sensing and in-sensor computing array based on a ferroelectric capacitor. The array is formed by several pixels, and each pixel is composed of several in-sensor computing devices, wherein in-sensor computing devices at the same position in different pixels are connected in parallel by means of connecting lines; and the in-sensor computing device is a deep-trench ferroelectric capacitor that is formed by a bottom electrode, a top electrode and a ferroelectric dielectric material between the two electrodes on an insulating substrate having a deep trench, and the ferroelectric dielectric material changes with temperature to produce a pyroelectric charge response related to the intensity of polarization. The present invention realizes zero-power-consumption in-situ infrared dynamic sensing, and reduces the power consumption and delay overhead of a system, and realizes weighted information sensing, realizes four-quadrant multiplication of sensed information and a weight within a single device, and achieves a complex in-sensor computing function.
Disclosed are a GaN power device and a manufacturing method thereof. The GaN power device includes a substrate, and a buffer layer, a GaN channel layer and a barrier layer sequentially stacked on the substrate from bottom to top. The barrier layer is provided with a p-GaN cap layer and a p-GaN thin layer, and the p-GaN thin layer is configured to cover the surface of the barrier layer and is connected to the p-GaN cap layer; the upper surface of the barrier layer is also provided with an input electrode and an output electrode, and a control electrode is provided on the upper surface of the p-GaN cap layer. The control electrode and the p-GaN thin layer are located between the input electrode and the output electrode.
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
The present invention relates to ionic liquids based on non-natural amino acids, a preparation method therefor, and use thereof, and particularly provides a substance combination for preparing a protein containing non-natural amino acids. The substance combination comprises: (1) one or more aminoacyl-tRNA synthetases, which can bind to mutated tRNAs; (2) one or more mutated tRNAs, in which the anticodon loop is mutated into a complementary sequence of the termination codon; and (3) a variety of ionic liquids based on non-natural amino acids. The substance combination can be used for recombination and expression of the protein containing non-natural amino acids. The ionic liquids based on non-natural amino acids can improve the read-through efficiency of genetic codon expansion systems for premature termination codons (PTCs) and/or the efficiency of inserting the non-natural amino acids.
NINGBO INSTITUTE OF MARINE MEDICINE, PEKING UNIVERSITY (China)
PEKING UNIVERSITY (China)
Inventor
Zhou, Demin
Ji, Dezhong
Zhang, Yuanjie
Abstract
The present invention belongs to the field of medicines and relates to a mutated influenza virus, a pharmaceutical composition, and use. Specifically, the present invention relates to a replication-defective influenza virus, a pharmaceutical composition, and use. More specifically, the present invention relates to a mutated influenza virus, wherein nucleic acid encoding HA protein and/or nucleic acid encoding NA protein of the influenza virus comprises one or more UAG codons. The replication-defective influenza virus or the pharmaceutical composition of the present invention can effectively treat or prevent tumors and has good application prospects.
The present invention relates to the field of biomedicine, in particular to the field of regenerative medicine. Specifically, the present invention relates to a compound for preparing myocardial cells and use thereof, and a method for differentiating pluripotent stem cells, such as induced pluripotent stem cells, into myocardial cells by using the compound.
A method for preparing a single crystal nitride Micro-LED array based on a non-single crystal substrate. A two-dimensional material mask layer is prepared to obtain a dislocation filter layer having a dislocation density less than 1×109cm-2, and to further obtain a single crystal nitride thin film having a dislocation density less than 1×108cm-2, so that an ultra-high quality single crystal nitride functional structure can be implemented on a non-single crystal substrate having large lattice mismatch and large coefficient of thermal expansion mismatch. In addition to being used for preparing a Micro-LED device, the method can further be used for preparing a radio frequency device, a power device, a light emitting device, a detection device, and the like, and has process universality. The interface bonding between an epitaxial structure and the non-single crystal substrate is destroyed by using a laser, so that nondestructive separation of the epitaxial structure and repeated utilization of the non-single crystal substrate can be realized, and the method is energy-saving, environment-friendly, and simple, and is suitable for batch production.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
27.
IMAGE-SENSING OPERATION UNIT AND METHOD FOR OPERATING SAME, AND IMAGE-SENSING ARITHMETIC UNIT AND ELECTRONIC DEVICE
Provided in the present disclosure are an image-sensing operation unit and a method for operating same, and an image sensing arithmetic unit and an electronic device. The image-sensing operation unit comprises a first photosensitive unit and a second photosensitive unit, wherein the second photosensitive unit is connected in series to the first photosensitive unit, and the changing direction of a first threshold voltage of the first photosensitive unit when receiving light is opposite to the changing direction of a second threshold voltage of the second photosensitive unit when receiving light, such that an in-situ logical operation is realized between optical input signals. Therefore, compared with the prior art, the image-sensing operation unit in the embodiments of the present disclosure can directly implement an in-situ logical processing function while performing photoelectric conversion, and therefore the image-sensing operation unit directly outputs an electrical signal representing a corresponding logical operation result. Thus, a traditional signal processing module for logical processing can be omitted, thereby effectively reducing the complexity of a system and improving the efficiency of optical-signal processing.
Disclosed is an automatic monitoring system for solution-phase synthesis, including a new type reactor, a sampling module, a power module, a monitoring analysis module and an upper computer, where the sampling module is connected to a pipe of the power module, the power module is connected to a pipe of the monitoring analysis module, the sampling module, the power module and the monitoring analysis module are electrically connected to the upper computer; the sampling module sucks a reaction solution contained in the new type reactor, the power module provides suction force for the sampling module according to suction instruction from the upper computer, injects the reaction solution into the monitoring analysis module, the monitoring analysis module generates a monitoring report according to the reaction solution, transmit the monitoring report to the upper computer, and the upper computer generates an analysis result according to the monitoring report.
An assistant system for solution-phase synthesis is disclosed. The assistant system for solution-phase synthesis includes: a reactor (1), a mixing device (2), a temperature control device (3) and a host computer (4). The reactor (1) is arranged on the mixing device (2), the mixing device (2) and the temperature control device (3) are both electrically connected to the host computer (4), so as to implement programmed temperature control over the entire assistant system for solution-phase synthesis. A bottle body (15) of the reactor (1) is arranged to include a reaction inner container (151), a temperature circulating layer (152) and a vacuum layer (153) from inside to outside in sequence.
B01J 19/18 - Stationary reactors having moving elements inside
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
30.
AUTOMATIC PREPARATION METHOD OF FONDAPARINUX SODIUM PENTOSACCHARIDE INTERMEDIATE
An automatic preparation method of a fondaparinux sodium pentosaccharide intermediate is provided via an automatic preparation device. In the preparation method, the automatic preparation of three components (D+EF+GH) is realized through automatic sampling and monitoring, and a fully-protected fondaparinux sodium pentosaccharide intermediate (shown in formula I) is obtained. In this way, automatic synthesis of the fondaparinux sodium pentosaccharide intermediate is realized, which saves manpower and improves efficiency and productivity, and has high safety and reproducibility. The preparation method can be directly monitored online, which is convenient for optimizing and monitoring a real-time status of reactions. Furthermore, automatic temperature control can better meet the needs of the reactions for temperature rise and fall. The preparation method adopts a “pre-activation” one-pot mode, which reduces the number of separations and is easy to operate. Moreover, the method selects commonly-used ester protecting groups, has higher stereoselectivity and yield, and can use general-purpose deprotection measures.
A method for preparing a large-size nitride bulk single crystal by using a single crystal two-dimensional material. A carrier nitride substrate is obtained by combining polycrystalline nitride primitives, a single crystal expansion layer and a single crystal cut-off layer are prepared on a two-dimensional material transferred from the upper surface and the lower surface of the carrier nitride substrate, a large-size nitride bulk single crystal having a centimeter-level thickness and a diameter of more than one hundred micrometers may be prepared by constructing a high-temperature high-pressure temperature gradient field to induce a single crystallization process from a single crystal AlN inducer to the whole nitride structure, and different nitride bulk single crystals such as GaN or AlN are prepared; a nitride bulk single crystal having extremely high crystal quality may be obtained by inducing recrystallization by means of a super high-quality single crystal AlN inducer, which features low process complexity and is suitable for mass production. The described method is applicable to the production industry of nitride semiconductor single crystal substrates; after a nitride bulk single crystal is cut, same may be used as a substrate for manufacturing high-performance light-emitting devices and electronic devices, and has important applications in various fields, such as laser illumination, radio frequency communication, and the like.
A method for nitride LED preparation and non-destructive interface separation. An atomic irradiation technology is used to modify a two-dimensional atomic crystal layer on a transparent substrate to obtain an irradiation region; a nitride LED structure is prepared on the modified two-dimensional atomic crystal layer, and then a support substrate is fixed by means of a metal functional layer; and visible laser light is incident from the back surface of the transparent substrate to directionally destroy the irradiation region of the two-dimensional atomic crystal layer, so as to obtain the overall structure of the nitride LED structure, the metal functional layer and the support substrate separated from the transparent substrate. The present invention can realize non-destructive interfacial separation and reuse of a transparent substrate, is compatible with nitride LED and Micro-LED epitaxial and machining processes, and is applied to manufacturing and separation of a wafer-level nitride LED and a micron-scale Micro-LED array, a nitride sacrificial layer is not required to be provided in advance, and an additional grinding and polishing process is not needed. The present invention is energy-saving and environmentally friendly, has a simple process and is suitable for mass production.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
An automated solution-phase synthesizer is provided with an automatic sample injection system, an assisting system for solution-phase synthesis, an automatic online monitoring system for solution-phase synthesis and a master computer. The automatic sample injection system completes an automatic sample injection operation according to a sample injection instruction from the master computer. The assisting system for solution-phase synthesis controls temperature and illumination of a solution to undergo reaction according to a temperature control instruction and an illumination control instruction from the master computer. The automatic online monitoring system for solution-phase synthesis monitors a reaction solution and generates a monitoring report. And, the master computer generates an experimental analysis result according to the monitoring report. In this way, an automatic process from sample injection to report generation in a solution-phase experiment process is completed, and further experimental labor cost is reduced and experimental efficiency is improved.
An automatic sample injection system is disclosed. The system includes: an inert gas conveying module (1), a sampling channel switching module (2), a quantification module (3), a disposal module (4), a liquid storage module (5), and a host computer. The host computer controls the sampling channel switching module (2) and the quantification module (3), so as to achieve accurate control of a sample injection amount. In addition, all reaction liquids can be independently conveyed separately by the sampling channel switching module (2) and the inert gas conveying module (1), such that stability and accuracy of sample injection are further improved, and accuracy of experimental reactions is ensured.
A monolithic integration preparation method for a full-color nitride semiconductor Micro-LED array. The method comprises: firstly preparing a composite conductive substrate; then, covering the composite conductive substrate with an insulating template to prepare a template substrate; covering the template substrate with monocrystalline graphene in a completely aligned manner so as to obtain a customized template graphene substrate, which comprises graphene array elements, wherein a blue-region graphene array element, a green-region graphene array element and a red-region graphene array element of each graphene array element have different surface properties; performing one-step in-situ epitaxial growth of all nitrides of a vertical structure to obtain a full-color Micro-LED array epitaxial wafer in situ in one step; and finally, packaging and preparing a transparent electrode so as to obtain a full-color nitride Micro-LED array, which has a vertical structure and emits light from the top face. The present invention does not need an additional micro-nano machining process, is energy-saving and environmentally friendly, is suitable for batch production, and is applied in display chips for enhanced/virtual reality, 8K super-definition display, etc.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
36.
SVM MODEL TRAINING METHOD AND APPARATUS, DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM
The embodiments of the present disclosure provide a method and apparatus for training an SVM model, a device and a computer-readable storage medium. The method comprises steps of: acquiring a dataset; loading the dataset; predicting the best storage format of the dataset online through an automatic tuning framework, and performing format conversion; and, executing an SMO algorithm to train an SVM model. In this way, the best data storage format and algorithm can be automatically selected according to the input dataset; in a global loop level, a large number of more efficient matrix multiplication operations are performed on the basis of the best data storage format to calculate a kernel matrix; and, in a local SMO solver level, finer memory optimization is performed by the register communication technology and the combined memory access method of the GPU, and the calculation resources of the hardware platform are fully utilized.
The present application relates to the technical field of artificial intelligence, and discloses an image processing method and apparatus, an electronic device, and a computer-readable storage medium. The image processing method comprises: acquiring a first watermark generated for a deepfake model and a second watermark carrying target information; acquiring a target coding model, the target coding model being used for performing watermark embedding on an image; and embedding the first watermark and the second watermark into an initial image by means of the target coding model to obtain a target image, a difference between the initial image and the target image being less than a reference threshold.
A heterogeneous multi-agent networking cooperative scheduling planning method based on autonomous obstacle bypassing. The method comprises: performing system configuration and transportation task management for multi-agent networking cooperative scheduling planning; performing cooperative path searching on each agent, which is about to execute a transportation task, in a system to obtain a corresponding path list; the agent performing motion planning to obtain an execution path; performing calculation according to the execution path to obtain a traveling speed; the agent performing autonomous obstacle bypassing during an operation process; and adjusting a time window. By using a time window algorithm and introducing the autonomous obstacle bypassing technology of agents, the present invention realizes the cooperative resolution of conflicts between the agents and autonomous obstacle bypassing, is more efficient, flexible and robust, and can involve more agents that can be accommodated in a system.
The present disclosure provides an application of RNA-dependent RNA polymerase (RDR) in treatment of cell proliferative diseases. The RDR can be widely used for inhibiting cell proliferation, apoptosis and migration of various tumors, thereby providing a new choice for clinical treatment of tumors.
Provided is a Pt(IV) complex. As a prodrug, the Pt(IV) complex is activated by irradiation to release a Pt(II) complex for the treatment of tumors. Also provided is a pharmaceutical composition including the Pt(IV) complex, and the use of the Pt(IV) complex in the preparation of a drug for treating tumors by means of irradiation activation. Further provided is a kit including the Pt(IV) complex and the description, wherein the description indicates that radiotherapy is performed after administration to treat tumors.
Peking University Ordos Research Institute of Energy (China)
Inventor
Wang, Jianxiao
He, Guannan
Gao, Feng
Huang, Jingsi
Song, Jie
Abstract
A method for coordinated control of an electro-hydrogen integrated system includes: constructing a clearing model for the integrated system having a fuel cell facility and a P2H production facility; introducing Lagrange multipliers into a power balance constraint and a hydrogen energy balance constraint in the clearing model; decomposing the clearing model into a first clearing model of a power subsystem and a second clearing model of a hydrogen subsystem based on a decomposition algorithm, solving the first and second clearing models to obtain interaction information; storing the interaction information in a blockchain smart contract, exchanging the blockchain smart contract for multiple rounds and adjusting strategies of each subsystem to obtain an optimal solution of the clearing model; and controlling the integrated system based on the optimal solution to provide a target electric quantity and a target hydrogen amount.
H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elements; Fuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
42.
RADIATION-ACTIVATED TETRAVALENT PLATINUM COMPLEX AND USE THEREOF
The present disclosure provides a complex of general formula (I), wherein M is tetravalent platinum; L is independently a neutral ligand or an anionic ligand when appearing each time; x is an integer of 1-5; P is a precursor ligand, the precursor ligand being a ligand of a tetravalent platinum ion which can be released from the complex after irradiation and converted into a functional molecule D to achieve functions such as medicine, fluorescence detection, or a functional material.
The present disclosure provides a complex of general formula (I), wherein M is tetravalent platinum; L is independently a neutral ligand or an anionic ligand when appearing each time; x is an integer of 1-5; P is a precursor ligand, the precursor ligand being a ligand of a tetravalent platinum ion which can be released from the complex after irradiation and converted into a functional molecule D to achieve functions such as medicine, fluorescence detection, or a functional material.
Lx-M-P (I)
A drug injection device based on an electrochemical reaction and a fabrication method for a drug injection pump, belonging to the technical field of medical devices are provided. A driving force is generated based on electrochemical reaction, and drug solution is automatically driven by the driving force to administer a drug to a patient. Meanwhile, three specific structures of the drug injection device based on the electrochemical reaction are provided, namely, a first drug injection pump based on electrochemical reaction, an insulin injection system, and a closed-loop control system, which can achieve the automation of the drug administration process.
xy22, where 0.6 ≤ x ≤ 1, and 0 ≤ y ≤ 0.1. Lithium ions and adjacent oxygen ions form tetrahedral coordination; and in an X-ray diffraction spectrum thereof, a main peak occurs between 17.9º and 18.1º, and a strong 131 crystal plane diffraction peak occurs within 67.0º-67.5º, which is a characteristic peak of the space group Cmca. The preparation method comprises: first synthesizing a precursor, i.e., P2-phase layered sodium cobalt oxide, by means of a solid-phase ball milling method or a coprecipitation method, and then subjecting same to ion exchange to obtain a T2-type lithium cobalt oxide layered positive electrode material.
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
Provided in the description is a liquid crystal/polymer composite electrically-controlled switchable film. The liquid crystal/polymer composite electrically-controlled switchable film comprises a liquid crystal material, a polymer matrix, and two layers of an ITO conductive film. The polymer matrix is sandwiched between the two layers of the ITO conductive film and is of a porous microstructure. The liquid crystal material is dispersed in the polymer matrix to form liquid crystal microdroplets, and the liquid crystal microdroplets have a vertically-oriented polymer network. The liquid crystal/polymer composite electrically-controlled switchable film has a unique composite microstructure; and in the composite microstructure, the polymer matrix of the porous microstructure endows the film with good mechanical processing performance, and moreover the vertically-oriented polymer network in the liquid crystal microdroplets further reduces the orientation difficulty of liquid crystal molecules, such that the driving voltage of the liquid crystal/polymer composite electrically-controlled switchable film is reduced, and the liquid crystal/polymer composite electrically-controlled switchable film is suitable for large-scale processing and production.
G02F 1/137 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering
G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
C08L 29/10 - Homopolymers or copolymers of unsaturated ethers
The present disclosure provides an operating method, apparatus, and device for an in-memory computing architecture for use in a neural network. The operating method comprises: generating a single pulse input signal encoded on the basis of discrete time; inputting the single pulse input signal into a memory array of an in-memory computing architecture so as to generate a bit line current signal corresponding to the memory array; and controlling a neuron circuit of the in-memory computing architecture to output, according to the bit line current signal, a single pulse output signal encoded on the basis of discrete time, the single pulse output signal acting as a single pulse input signal in a next in-memory calculation cycle of the memory array of a next layer of a neural network. Therefore, a single pulse input into the in-memory calculation architecture can be implemented by means of the single pulse input signal encoded on the basis of discrete time, thereby greatly reducing the number of input pulses and greatly reducing dynamic power consumption of the memory array and the neuron circuit.
Provided in the present invention are a video transmission quality evaluation and optimization method and system based on user behavior indexes. The method comprises: establishing an exit rate model according to a session duration of a user watching a video, and a playing state of each second; calculating a state transition probability according to playing states of every two adjacent seconds; according to the transition probability and the exit rate, calculating mathematical expectation values of stay durations corresponding to positions, network connection types, CDNs and bitrates within different time periods; and according to a stay duration expectation, for the position and a network connection type of a given user, selecting a bitrate and a CDN which allow the longest stay duration expectation. By means of the present invention, a model is established on the basis of two user behavior indexes, i.e. an exit rate and a stay duration, and video transmission quality scores corresponding to different bitrates and CDNs are evaluated for the specific positions and network connection types of different users, such that a bitrate and a CDN which can optimize the viewing experience of a user are accurately given, and the video transmission quality can be greatly improved.
H04N 21/44 - Processing of video elementary streams, e.g. splicing a video clip retrieved from local storage with an incoming video stream or rendering scenes according to MPEG-4 scene graphs
The present invention relates to the technical field of genetic engineering, and in particular to an anti-senescent drug screening method. The screening method comprises: treating a GFP-progerin protein overexpressing cell by using a drug to be screened; comparing the treated GFP-progerin protein overexpressing cell with a GFP-progerin protein overexpressing cell that is not treated by the drug to be screened; and determining, according to a change in cell morphology, an anti-senescent function of the drug to be screened. The present invention finds that a progerin protein positioned on a nuclear membrane can cause a cell to show obvious characteristics of senescence, including nuclear membrane shrinkage and nuclear membrane budding. However, a progerin protein positioned in a cell nucleus would not cause a cell to show obvious characteristics of senescence. If a drug has an anti-senescent effect, a progerin protein positioned on a nuclear membrane would be transferred into a cell nucleus. On this basis, the present invention provides an anti-senescent drug screening method, capable of accurately and efficiently screening out an anti-senescent drug.
Disclosed is use of chaetocin in anti-aging. The present invention adopts an aging cell model and an aging mouse model to screen and obtain a drug, chaetocin, which has the effect of anti-aging. By means of cell and mouse experiment verification, chaetocin not only can effectively inhibit alopecia, weight loss, cardiac fibrosis, liver fibrosis, renal fibrosis, spleen fibrosis, pulmonary fibrosis, adventitial fibrosis, and smooth muscle loss, but can also prolong the life span, increase abdominal fat, and alleviate cardiac inflammation, renal inflammation, liver inflammation, pulmonary inflammation, spleen inflammation, small intestine inflammation, and skin inflammation. Chaetocin provided by the present invention can be used as an anti-aging drug, and is applied to research and development of various drugs for treating aging-related diseases.
A61K 31/548 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame having two or more sulfur atoms in the same ring
A61P 39/00 - General protective or antinoxious agents
A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
A61P 43/00 - Drugs for specific purposes, not provided for in groups
50.
USE OF IMMUNE EFFICACY OR CLINICAL RELATIVE IMMUNE EFFICACY IN EVALUATION OF VACCINE RESPONSE STRENGTH OF SUBJECT
A liquid crystal/polymer composite electrically controlled dimming film is provided, including a liquid crystal material, a polymer matrix, and two layers of conductive substrates. The polymer matrix is sandwiched between the two layers of conductive substrates, and the polymer matrix has a porous microstructure. The liquid crystal material is dispersed in the polymer matrix to form liquid crystal microdroplets, and the liquid crystal microdroplets have vertically oriented polymer networks. The liquid crystal/polymer composite electrically controlled dimming film has a unique composite microstructure. In this composite microstructure, the polymer matrix of the porous microstructure gives the film with good mechanical processing performance. In addition, the vertically oriented polymer networks in the liquid crystal microdroplets further reduces the orientation difficulty of liquid crystal molecules, which is conducive to reducing the driving voltage of the liquid crystal/polymer composite electrically controlled dimming film, and is suitable for large area processing and production.
G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
G02F 1/137 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering
Disclosed is use of an RPN11 marker in the detection of myeloma and disease risk thereof, prognosis analysis and a treatment medicament, comprising: a detection reagent and a kit for detecting smoldering myeloma, multiple myeloma and disease risk thereof, molecular typing of patients with multiple myeloma, prognosis analysis of the patients with multiple myeloma, and predicting the treatment reactivity to bortezomib of multiple myeloma patients, and use of an RPN11 inhibitor in the preparation of a pharmaceutical composition for treating drug-resistant t(4; 14) translocation and RPN11 high-expression multiple myeloma. In particular, combining the RPN11 and histone methyltransferase MMSET provides more sensitive and accurate detection performance, avoids situations of patient genotype not matching disease development predictions, while total survival and prognosis conditions of MM patients with t(4;14) translocation can be effectively predicted. Furthermore, the pharmaceutical composition has a synergistic effect, thereby effectively promoting the apoptosis of the multiple myeloma cells with t(4;14) translocation.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 31/00 - Medicinal preparations containing organic active ingredients
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Disclosed in the present invention is a low-illumination image enhancement method using long-exposure compensation. The method comprises: 1) collecting a low-illumination training data set, wherein each training sample in the low-illumination training data set comprises a low-illumination image and a normal-illumination image of the same scene, and generating, according to each training sample, a group of a short-exposure image, a long-exposure image and a real-illumination image, which correspond to each other, so as to obtain a synthetic data set S; 2) training a low-illumination enhancement model by using the synthetic data set S, wherein the low-illumination enhancement model comprises M-1 feature alignment modules and M-1 brightening modules; and 3) inputting a short-exposure image to be brightened and a corresponding blurred long-exposure image into the trained low-illumination enhancement model, so as to obtain a corresponding low-illumination enhanced image. The present invention can significantly improve the performance of low-illumination image enhancement.
The present invention relates to a trifunctional compound, comprising at least one covalent warhead capable of forming a reversible or irreversible covalent linkage with a protein or tissue. The present invention further relates to a pharmaceutical composition and kit comprising the trifunctional compound, and use of the trifunctional compound in the diagnosis or treatment of diseases.
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61P 25/00 - Drugs for disorders of the nervous system
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
55.
Device and method for testing effective diffusion coefficient of helium in helium-bearing natural gas
A device and method for testing an effective diffusion coefficient of helium in helium-bearing natural gas solves the problem that there is currently no systematic method or supporting experimental device to quantitatively characterize the diffusion behavior of helium in helium-bearing natural gas. The device includes a diffusion system and a gas sampling and analysis system. The diffusion system includes an upstream diffusion chamber, a downstream diffusion chamber, and a true triaxial apparatus, and is configured to simulate a gas diffusion process. The gas sampling and analysis system includes an upstream gas sample retention chamber, a downstream gas sample retention chamber, and a chromatographic analyzer, and is configured to sample a diffusing gas and analyze composition of the gas. By performing diffusion process simulation, gas sampling and analysis, and data calculation and fitting, the effective diffusion coefficient of helium in the helium-bearing natural gas is finally acquired.
BEIJING SUPERSTRING ACADEMY OF MEMORY TECHNOLOGY (China)
PEKING UNIVERSITY (China)
Inventor
Huang, Qianqian
Yang, Mengxuan
Huang, Ru
Abstract
A ferroelectric memory and a ferroelectric capacitor thereof and a preparation method therefor, belonging to the field of semiconductor storage devices. A layer of antiferroelectric dielectric layer is introduced before a ferroelectric dielectric layer in the ferroelectric capacitor grows,. When the antiferroelectric layer is used as a seed layer, a crystallization template is provided for the ferroelectric dielectric layer, so that the proportion of a ferroelectric phase is increased, the residual polarization intensity is improved, and the storage window is further improved. In addition, when the antiferroelectric layer is used as an interface layer, said layer has lower surface energy and a more stable electrode contact interface than other phases, interface defects and leakage currents are reduced, the oxygen vacancy concentration is reduced, generation of oxygen vacancies during an electrical circulation process is inhibited, the durability is improved, and the reliability of the memory is improved. The present invention facilitates the low-power-consumption, high-performance and high-reliability use of the ferroelectric random access memory.
Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5′-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.
A method for fabricating a vertical channel nanowire transistor with asymmetric stress distribution includes: (A) growing epitaxially a single-crystal material on a substrate; forming a laminate of a bottom source-drain material and a channel material; and generating a vertical uniaxial stress in the lightly-doped channel layer; (B) forming an inter-device isolation in an active layer; (C) forming a vertical channel by patterning; (D) depositing a dielectric layer to form a bottom gate isolation; (E) depositing a dummy gate layer followed by patterning to form a dummy gate pattern; (F) depositing a dielectric layer to form a top gate isolation; (G) patterning the top gate isolation; and forming a top source-drain by epitaxy growth; (H) removing a dummy gate; and forming a gate oxide layer and a metal gate; and (I) forming metal contact at individual ends of the device.
H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors
59.
METHOD FOR FABRICATING GATE-ALL-AROUND (GAA) STRUCTURE
A method for fabricating a gate-all-around (GAA) structure, including: etching a superlattice laminate to form active regions; performing selective epitaxy growth of a silicon germanium (SiGe) layer to form a SiGe-wrapped Si nanosheet stacked structure, where the SiGe layer and the SiGe/Silicon (Si) periodic superlattice laminate have the same germanium (Ge) content; after silicon oxide is backfilled and chemical mechanical polishing (CMP) is performed on the active regions, performing an amorphous-silicon dummy-gate process on a top of the active regions; removing dummy gate, and selectively etching the SiGe layer; and forming hole-trench structures connected with trenches of the dummy gate around the Si nanosheet stacked structure.
The present application relates to the technical field of semiconductors, and provides a Schottky transistor, a diode, and a cold source semiconductor structure and a preparation method therefor. The cold source semiconductor structure comprises a heavily doped P-type region, a metal region, and a lightly doped N-type region. The metal region is connected between the heavily doped P-type region and the lightly doped N-type region, and the metal region is platinum silicide, and the end of the lightly doped N-type region adjacent to the metal region is doped with sulfide ions. The present application can lower a Schottky barrier in contact with a semiconductor structure, thereby improving an on-state current.
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 21/336 - Field-effect transistors with an insulated gate
H01L 21/329 - Multistep processes for the manufacture of devices of the bipolar type, e.g. diodes, transistors, thyristors the devices comprising one or two electrodes, e.g. diodes
61.
ENCODING METHOD, DECODING METHOD, AND ELECTRONIC DEVICE
Provided in the embodiments of the present application are an encoding method, a decoding method, and an electronic device. The encoding method comprises: firstly, acquiring data to be encoded; then, performing feature transformation on said data according to a preset network, so as to obtain a latent feature corresponding to said data; next, performing wavelet decomposition on the latent feature, so as to obtain N wavelet coefficient groups, wherein N is an integer greater than 1; and then respectively performing vector quantization on the N wavelet coefficient groups, so as to obtain a code stream of said data. Compared with directly performing vector quantization on a latent feature, vector quantization is performed after the latent feature is decomposed into a plurality of wavelet coefficient groups of smaller size, such that the size of a codebook which is used for vector quantization is smaller under the same code rate, and thus the storage space which is occupied by the codebook can be reduced.
H04N 19/63 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using transform coding using sub-band based transform, e.g. wavelets
62.
CELL DIFFERENTIATION BASED ON MACHINE LEARNING USING DYNAMIC CELL IMAGES
The present invention relates to the field of biomedicine, in particular to a cell differentiation method based on machine learning using dynamic cell images, and more particularly to a method and apparatus for obtaining differentiated target cells (such as cardiomyocytes) from starting cells such as pluripotent stem cells (such as induced pluripotent stem cells) under the assistance of machine learning using dynamic cell images.
The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.
Provided in the embodiments of the present application are a transaction processing method and apparatus, and an electronic device. The method comprises: detecting whether target data, which a first transaction targets, is occupied by a second transaction, wherein the first transaction comprises an operation for processing the target data, and the second transaction is another transaction, which is in parallel with the first transaction; and in response to the target data being occupied by the second transaction and according to the type of occupation of the target data by the second transaction and the type of the operation that is comprised in the first transaction and is used for processing the target data, executing the operation comprised in the first transaction, so as to process the target data. By means of the embodiments of the present application, system calling is not required to control parallel first and second transactions with regard to a scenario in which the same target data is processed, thereby avoiding frequent involvement in a kernel mode of an operating system, improving the transaction processing efficiency, and increasing the throughput of the system.
Provided herein pertains to the biomedical field, and particularly relates to a method for activating N-oxide prodrugs with radiation, and a method of treating or suppressing a cancer, reducing its severity, lowering its risk or inhibiting its metastasis in an individual. The method comprises administering to the individual a therapeutically effective amount of an N-oxide prodrug, and radiating the individual with a therapeutically effective amount of radiotherapy.
A computer-implemented method for data processing based on a data value includes: calculating a value of each piece of original data based on a utility function associated with a service revenue; acquiring pieces of high-value data from the original data based on the value of each piece of original data; and performing a service prediction on the pieces of high-value data.
A method for constructing a real-geographic-space scene in real time based on a panoramic-video technique is provided. By using a measuring robot and the attitude sensors, accurately determining the geographic coordinates and the attitudes of the cameras, where the cameras may be installed in a fixed or stringing manner, where in the fixing type a plurality of neighboring videos at the same moment undergo orthographic correction and splicing, and in the stringing type the cameras are installed to a guiding device and may locally, independently and quickly move and shoot, and the videos of the neighboring cameras are spliced in real time; and fusing the videos, the geographic coordinates and the environment sounds that satisfy the delay time, to form a scene video streaming.
The present application relates to the technical field of deep learning and pose estimation, and more particularly, to a contextual instance decoupling (CID)-based multi-person pose estimation (MPPE) method and apparatus. The method includes: acquiring a preset number of images containing multiple persons; inputting the images containing multiple persons, as a training sample, into a CID-based MPPE model for training; and performing pose estimation on a target image using the trained CID-based MPPE model, the CID-based MPPE model being provided with an instance information abstraction module, a global feature decoupling module and a heatmap estimation module. The method and apparatus of the present application can explore context clues over a greater range, thus being robust to spatial detection errors and superior in both accuracy and efficiency.
Provided are a diazo compound, a preparation method therefor, and a use thereof. The diazo compound has a structure as shown in formula (I), wherein R1 represents H, an alkyl, a halogen, an alkoxy or an alkylamino; and R2 represents an aryl. On the basis of using the diazo compound as a derivatization reagent, after derivatization treatment, the mass spectrometry response of a small molecule carboxylic acid can be clearly enhanced, the detection sensitivity is improved, and therefore the detection accuracy is improved. Moreover, the derivatized small molecule carboxylic acid does not need to be provided with a special chromatographic column and does not need to be provided with a special mobile phase, the optimal separation effect can be achieved in a shorter time with a lower cost, high-throughput sample detection is better facilitated, and the detection accuracy is improved. In particular, on the basis of using the diazo compound as a derivatization reagent, the beneficial effects of in-situ derivative cell samples can be effectively achieved.
C07D 215/14 - Radicals substituted by oxygen atoms
C07C 245/18 - Diazo compounds, i.e. compounds having the free valencies of N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
Provided is a method for biosynthesis of a protein heterocatenane. The basic structure of a protein precursor sequence of the protein heterocatenane comprises form an N-terminal to a C-terminal: L1-1-X-L1-2-(in situ enzyme cutting site)-L2-1-X-L2-2, wherein the Xs represent entangled motifs for forming dimers, the two Xs can be the same or different, L1-1/L1-2 and L2-1/L2-2 represent two pairs of cyclization motifs that undergo an orthogonal coupling reaction in cellulo, and the two pairs of cyclization motifs can be two orthogonal peptide-protein reactive pairs, or combinations of peptide-protein reactive pairs and split inteins, or two orthogonal split inteins. When the peptide-protein reactive pair and the split intein are combined for use, biosynthesis of branched protein heterocatenanes can be achieved; and when the two orthogonal split inteins are combined for use, the protein heterocatenane having a completely cyclized main chain can be obtained.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
The present application provides circular RNAs (circRNAs) encoding therapeutic polyeptides (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein). In some embodiments, the present application provides circRNA vaccines against a coronavirus such as SARS-CoV-2. In some embodiments, the circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike (S) protein or a fragment thereof of a coronavirus. Also provided are methods of treating or preventing a disease or condition using the circRNAs or compositions thereof.
A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
72.
NEAR-INFRARED EMITTING PORPHYRIN COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention provides a porphyrin compound and its preparation method and uses, and also provides a pharmaceutical composition comprising the porphyrin compound as the active ingredient. The porphyrin compound according to the present invention has a novel modified structure, and can be derived and modified at multiple sites to achieve the biocompatibility modification and functional changes. The porphyrin compound has the absorption wavelength located in the near infrared region, which is contributed to realize the deeper tissue penetration and excellent photodynamic therapy activity.
C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
73.
SRAM STORAGE AND COMPUTING INTEGRATED CHIP BASED ON CAPACITIVE COUPLING
Provided in the present disclosure is an SRAM storage and computing integrated chip based on capacitive coupling. The SRAM storage and computing integrated chip comprises an input module, a bitwise multiplication module, a capacitance attenuation module and an output module, wherein the input module is used to receive input data; the bitwise multiplication module is used to realize a multiplication operation on the input data and storage data, so as to obtain a multiplication operation result; and the capacitance attenuation module is used to layer the structure of a capacitance attenuator to realize layered accumulation of multiplication operation results. The structure is simpler, and the calculation time is also shorter such that a number accumulation result can be quickly obtained, thereby improving the energy efficiency of a multiplication accumulation operation, and increasing the computation throughput.
A double-stranded DNA deaminase mutant for constructing a mitochondrial base editor, a base editor for mitochondrial DNA base editing, and a method for base editing.
Provided in the embodiments of the present disclosure are a Linux kernel optimization processing method and apparatus, and a storage medium and an electronic apparatus. The method comprises: generating a fine optimization configuration table according to a user configuration table; performing targeted interpolation on a kernel source code, and running a target program, so as to obtain kernel feedback information; and performing optimization processing on the kernel source code according to the fine optimization configuration table and the kernel feedback information, so as to obtain an optimized kernel. Therefore, the problems in the related art of the granularity of an object on which kernel source code optimization acts being relatively large, it being impossible to fully exert a compilation optimization capability of a modern compiler, and it being impossible to flexibly control the range of compilation optimization can be solved; and an optimization process is automatically completed by using a compiler plug-in, such that an action range of Linux kernel feedback type optimization can be freely controlled, and the running performance of an application program is additionally improved without modifying the application program.
The present disclosure provides a position prediction method and apparatus, an electronic device, and a storage medium. The method comprises: determining coordinates of three trajectory points at equal time intervals in a historical trajectory; activating a first spiking neuron in a position prediction model on the basis of the coordinates of the three trajectory points, to obtain spikes corresponding to each of the three trajectory points, output by the activated first spiking neuron; on the basis of the spikes corresponding to each of the three trajectory points and a connection strength between the first spiking neuron and a second spiking neuron in the position prediction model, activating the second spiking neuron, to obtain a position prediction result outputted by the activated second spiking neuron. In the present method, a position prediction model constructed using a spiking neural network is used, and the model activates a spiking neuron and outputs a position prediction result according to coordinate information of three input trajectory points, thereby reducing calculation complexity, shortening a delay from input to output, improving the effect of the prediction result, and further improving a real-time response effect.
A compound of a GPR132 regulator, a pharmaceutically acceptable salt or ester, a prodrug, a stereoisomer, a hydrate, a solvate, a crystal form, or a metabolite form thereof, as well as a preparation method therefor and medicinal use thereof.
C07D 307/85 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 333/70 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
NINGBO INSTITUTE OF MARINE MEDICINE, PEKING UNIVERSITY (China)
PEKING UNIVERSITY (China)
Inventor
Zhou, Demin
Ji, Dezhong
Sun, Jiaqi
Zhang, Bo
Abstract
A combination of PEGylated IL-2 variants with different receptor biases is provided. The combination inhibits the amplification of immunosuppressive lymphocytes and reduces the terminal differentiation and depletion of effector lymphocytes by means of a synergistic effect, possessing a synergistic anti-tumor effect, so that the combination can be used for enhancing immune response and treating proliferative diseases such as tumors. In addition, the combination can also be used for in vitro culture of immune cells in adoptive cell immunotherapy, reducing the aging and depletion of immune cells, thereby leading the fate of the immune cells in the adoptive cell immunotherapy to long-term immunity. Also provided are a combined therapy for enhancing immune response and treating proliferative diseases such as tumors, and an in vitro method for preparing or culturing immune cells for adoptive cell therapy.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
The present invention relates to a GPCR regulator and use thereof, and particularly provides a compound represented by formula (I), or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a pharmaceutically acceptable ester of the compound.
C07D 307/79 - Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 333/62 - Benzo [b] thiophenes; Hydrogenated benzo [b] thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 209/10 - Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
Disclosed are an FXR regulator and use thereof, and specifically disclosed are a compound represented by formula I, or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a pharmaceutically acceptable ester of the compound.
C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 307/82 - Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07C 309/76 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
An automatic design method for a storage-calculation module interconnection circuit of a hardware accelerator. An expected behavior of data in a storage module of a hardware accelerator is analyzed by means of space-time transformation (STT), data reuse in the storage module is calculated and classified, an optimal storage-calculation module interconnection circuit mode is further automatically selected, and multicast interconnection or rotary interconnection is achieved. The present method can effectively improve the interconnection efficiency of a hardware storage-calculation module, and reduce the consumption of storage resources.
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
82.
ELECTROOSMOTIC PUMP, INSULIN PUMP AND INSULIN PUMP SYSTEM
The present disclosure relates to the technical field of electroosmotic pumps (EOPs) and wearable medical equipment, and in particular, to an EOP, an insulin pump and an insulin pump system. The EOP of the present disclosure is cost-effective and has low power consumption, and can replace an existing mechanical pump device as a driving device in the insulin pump to achieve miniaturization of the insulin pump and lower the price of the insulin pump. In addition, when the EOP adopts a modified flexible membrane with penetrating pores, the EOP can pump and infuse a high-concentration insulin solution to achieve miniaturization and high efficiency of the insulin pump, which is conducive to the integration of wearable medical devices for treating diabetes.
An embodiment of the present application provides a manufacturing method of a microneedle biosensor, and relates to the technical field of medical instruments. The method includes: providing a mold, where a microneedle array is formed on the mold; casting a liquid polymer material on the mold, and drying and then demolding to form a sensor substrate, where a hollow microneedle array is provided on the sensor substrate; penetrating through a tip of each microneedle in the hollow microneedle array; and forming a working electrode and a counter electrode on the sensor substrate, where the working electrode and the counter electrode each cover a part of the hollow microneedle array.
Provided is a chemical tagging-based method for modified nucleoside sequencing, enrichment, and measurement, comprising reacting a thiol compound with an N-hydroxymethyl chemically modified nucleoside, then using a chemical tag such as biotin to perform tagging, and then enriching and sequencing or measuring. In the method of the present invention, selective chemical tagging is used, and the selectivity of the chemical reaction ensures result specificity and reduces false positive results.
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
Disclosed in the present invention is a gradient field-based point cloud repair method. Firstly, a distributed global gradient field is estimated from an input degenerated point cloud; then gradient ascent is carried out by using the estimated gradient field, and points are converged to a potential surface, so as to complete point cloud repair.
The present disclosure provides a method of preventing or treating virus infection by inhibiting Lipin1, wherein the virus infection is caused by a positive strand RNA virus. Also provided are use of Lipin1 inhibitor in treating positive strand RNA virus infection, as well as a combined use of the Lipin1 inhibitor and an additional antiviral treatment.
A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A method for growing a large-area high-performance hole conductive tungsten diselenide single crystal on a silicon-based insulating layer. A molten salt reacts with a tungsten source to generate an intermediate product having lower melting point and higher vapor pressure, such that a tungsten diselenide single crystal is more easily grown on a silicon oxide or high-dielectric-constant insulating layer on a silicon substrate on the basis of the principle of chemical vapor deposition, and meanwhile, large-area growth of tungsten diselenide is achieved by changing a substrate placing mode. The method may effectively achieve layer number controlled growth of large-area multi-layer tungsten diselenide single crystals, thus a silicon-based compatible high-mobility hole conductive two-dimensional material can be obtained, the operation is easy, transfer is not needed, and the material quality is higher.
Provided are an amino acid polymer, and a preparation method therefor and the use thereof as a natural gas hydrate kinetic inhibitor. The provided amino acid polymer structure contains an isopropyl side chain group. The isopropyl has relatively strong hydrophobicity, whereby the hydrophobic isopropyl can solidify the structure of water molecules, such that water molecules around the isopropyl can be bound, and the cage-shaped water structure of a natural gas hydrate is not easy to form, thereby inhibiting the nucleation of the natural gas hydrate. Therefore, the nucleation of the natural gas hydrate can be effectively delayed and the generation rate of the natural gas hydrate can be reduced under the condition of a low dosage concentration and a high supercooling degree environment, and the present invention has the advantages of a good inhibition effect, a small dosage, a low cost, wide applicability, etc.
The present invention belongs to the technical field of chemical production, and particularly relates to an amino acid polymer, and a preparation method therefor and the use thereof as a natural gas hydrate kinetic inhibitor. An S=O bond on a side chain of the provided amino acid polymer can form a hydrogen bond with water molecules, such that water molecules around the S=O bond are interfered, and the cage-shaped water structure of a natural gas hydrate is not easy to form, thereby inhibiting the nucleation of the natural gas hydrate. In addition, the main chain of the polymerization unit as shown in formula 1 contains an amide group, and N and O atoms in the amide group can be adsorbed on the surface of the natural gas hydrate by means of hydrogen bonds, such that further growth of natural gas hydrate crystals is inhibited. Therefore, the provided amino acid polymer can effectively delay the nucleation of the natural gas hydrate and reduce the generation rate of the natural gas hydrate under the condition of a low dosage concentration and a high supercooling degree environment, and has the advantages of a good inhibition effect, a small dosage, a low cost, wide applicability, etc.
A method for highly orienting platinum on the basis of vertical heteroepitaxy of single crystal tungsten diselenide, comprising: using single crystal tungsten diselenide as an epitaxial substrate; depositing a polycrystalline platinum thin film on the epitaxy of the epitaxial substrate; and then, longitudinally inducing, by means of oxygen annealing, platinum to form a highly oriented platinum thin film along tungsten diselenide, wherein a gap between the platinum and the tungsten diselenide is smaller than the Van der Waals distance, so that a better two-dimensional material is formed to contact a metal, thereby reducing the Schottky barrier height for a metal-semiconductor contact. According to the method, the problem that a highly oriented metal thin film is difficult to prepare, limited in size and high in costs is solved. A tungsten diselenide field effect transistor is a PMOS, and achieves high-quality contact between a tungsten diselenide semiconductor and a metal by means of the method, thereby reducing contact resistance, being complementary to an NMOS field effect transistor, and improving the performance of a nanosheet CMOS device.
Disclosed is a method for implementing an adaptive stochastic spiking neuron based on a ferroelectric field effect transistor, relating to the technical field of spiking neurons in neuromorphic computing. Hardware in the method includes a ferroelectric field effect transistor (fefet), an n-type mosfet, and an l-fefet formed by enhancing a polarization degradation characteristic of a ferroelectric material for the ferroelectric field-effect transistor, wherein a series structure of the fefet and the n-type mosfet adaptively modulates a voltage pulse signal transmitted from a synapse. The l-fefet has a gate terminal connected to a source terminal of the fefet to receive the modulated pulse signal, and simulates integration, leakage, and stochastic spike firing characteristics of a biological neuron, thereby implementing an advanced function of adaptive stochastic spike firing of the neuron.
G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron
G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using ferroelectric elements
92.
BORON CARRYING AGENT FOR INTEGRATED TUMOR DIAGNOSIS AND TREATMENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
The present invention relates to a boron carrying agent for integrated tumor diagnosis and treatment, and a preparation method therefor and use thereof. Provided is a compound represented by formula I: wherein an R group is hydrogen or alkyl. A boron atom connected to the benzene ring may be 10B or natural boron, and at least one fluorine atom in —BF 3- is radiolabeled. The present invention generally relates to the fields of radiopharmaceuticals and nuclear medicine. The compound in the present invention can be used for a drug for integrated diagnosis and treatment in tumor diagnosis and BNCT treatment, and by means of the same chemical structure, a reliable distribution result of a drug in vivo is provided.
The present disclosure relates to a silicon-based fan out package structure including embedded manifold type microchannels, which includes: a chip, which includes a substrate and embedded microchannels located on a back of the substrate; a silicon-based adapter plate, which includes a groove for burying the chip, a manifold channel located below the groove and communicated with the groove, a liquid inlet and a liquid outlet; a low temperature sealing layer for sealingly communicating the embedded microchannels with the manifold channel, the low temperature sealing layer being located between the chip and the silicon-based adapter plate; and a rewiring layer at a top of the chip. The present disclosure also relates to a preparation method for a silicon-based fan out package structure including embedded manifold type microchannels. The silicon-based fan out package structure of the present disclosure has both low temperature process compatibility and packaging compatibility and high heat dissipation efficiency. The embedded manifold type microchannels of the present disclosure have the advantages of short flow distance, small flow resistance and small thermal resistance, and are more suitable for being integrated in high-power chips for efficient heat dissipation.
H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
H01L 23/427 - Cooling by change of state, e.g. use of heat pipes
H01L 21/48 - Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups
94.
METABOLIC DISEASE THERAPEUTIC AGENT OR PREVENTIVE AGENT
The present invention relates to a use of a compound and an extract derived from natural fungus Antrodia camphorata in the preparation of an FGF21 agonist and/or an RDH10 agonist.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/00 - Drugs for disorders of the cardiovascular system
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 17/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta[a]hydrophenanthrene skeleton
95.
INDUCED TOTIPOTENT POTENTIAL STEM CELLS, METHODS OF MAKING AND USING
Factors for deriving totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos are provided. A cell culture media composition for deriving cell totipotency in vitro of isolated cells and an isolated chemically induced totipotent potential stem cells(ciTPSCs) obtained by using the composition are provided. The composition comprises chemical derivers of totipotency (CDTs) from each of the following groups (l) an HDAC inhibitor, (2) a Dot1L inhibitor, (3) an RARy agonist, and (4) optionally, a GSK inhibitor, in amounts effective to induce an untreated cell into a totipotent potential stem (TPS) cell. The ciTPSCs can be used in, e.g., cell therapy and tissue engineering.
A charging base station network system, comprising: a plurality of unmanned aerial vehicle base stations and a central command center (U0); the unmanned aerial vehicle base stations are distributed in a preset area according to a preset distance, the preset distance being the distance between any two adjacent unmanned aerial vehicle base stations; and the central command center (U0) and the unmanned aerial vehicle base stations perform signal communication. Each unmanned aerial vehicle base station comprises: a power generation and storage platform, an unmanned aerial vehicle group (U3), a charging platform (U5), and a base station console (U6). The power generation and storage platforms are configured to supply power to the unmanned aerial vehicle base stations, the power supply amount of the power generation and storage platforms being regulated on the basis of the power consumption requirements of the charging base station network system; the base station consoles (U6) transmit signals to and receive signals from the central command center (U0) and the unmanned aerial vehicle base stations, and acquire information such as the location, environment and working conditions of the unmanned aerial vehicle base stations; each unmanned aerial vehicle group (U3) comprises at least two unmanned aerial vehicles which leave the unmanned aerial vehicle base station to execute a flight task; and the charging platforms (U5) are electrically connected to the unmanned aerial vehicles to charge the unmanned aerial vehicles. The charging base station network system solves the problem of on-site charging of unmanned aerial vehicles which are sent to an area far away from a populated area to carry out investigation work.
The present invention relates to a relay device based on multi-path scheduling, at least comprising: at least one communication-receiving module, at least one hardware interface module, and at least one data-processing module, wherein the data-processing module, according to a specific type of target data, distributes the user data received through the communication-receiving module to a first processing path that processes the data in a predetermined manner and a second processing path that is independent of the first processing path and bypasses a kernel protocol stack. The data-processing module employs a multi-stage continuous scheduling manner to drive the user data in the second processing path to be transmitted in at least two mutually independent communication paths, thereby realizing multi-path transmission between the plural clients and the plural servers. This configuration not only lifts the logic of packet scheduling to the application layer, but also ensures path quality, QoE, and fairness while maintaining the multi-connection, multi-path, application-independent nature.
The present invention relates to a polyethylene glycol modified zwitterionic fluorescent probe. A core luminous group of the fluorescent probe of the present invention is a heptamethine chain which is connected to a phenoxy bridge and is of a rigid ring structure in the center; two ends of the heptamethine chain are two sulfonic acid indole groups; two polyethylene glycol chains are connected to the indole groups; a tumor targeting ligand is connected to the luminous group by means of a polyethylene glycol chain and a basic amino acid linking group; and the probe of the present invention can be connected to polypeptide, small molecules, and an antibody which have a tumor targeting function, so that tumor targeting near-infrared fluorescence imaging is realized. The probe of the present invention is simple in synthesis method, high in fluorescence quantum yield, low in non-specific fluorescence signal, and high in tumor imaging signal-to-noise ratio, and therefore, the probe has very good druggability and is very suitable for industrial production and clinical popularization.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 9/19 - Particulate form, e.g. powders lyophilised
A method for low frequency somatic cell mutation identification and quantification, relating specifically to a method for transposon copy number and genome location identification. Specific sites of different transposon families are used, transposon insertion sequences are specifically enriched via library construction, high-throughput sequencing and bioinformatics analysis are used, and genome locations, copy numbers and types of transposons within samples are accurately identified. The method economically and accurately identifies copy numbers and genome locations of transposons.
Disclosed are a neural unit circuit, a spiking neural network and an intelligent Internet of Things chip. The neural unit circuit comprises: a dendritic circuit, a synaptic circuit comprising a membrane potential capacitor, a cell body circuit, and a time planning module. According to an input pulse signal or an output pulse signal of a neuron cell body circuit of a previous layer, the dendritic circuit generates a reset signal and a calculation signal that does not overlap with the reset signal. The synaptic circuit stores a weight, and performs a potential accumulation operation of the membrane potential capacitor according to the stored weight and an output of the dendritic circuit. The cell body circuit compares the membrane potential of the membrane potential capacitor with a threshold voltage to determine whether to output a pulse signal. The time planning module is used for generating a time sequence according to the input pulse signal or an enable signal outputted by a neural unit of the previous layer, so that the threshold voltage is stored in a threshold capacitor before a cell body performs a comparison operation, and the cell body is triggered to perform the comparison operation. According to the present invention, a final event driving circuit having a system level and a module level to a circuit level is achieved.
