A quantum computing system is set forth, comprising a photon source for generating short duration single photon pulses, at least one temporal interferometric network for time-bin encoding each short duration single photon pulse in a single spatial mode, wherein the temporal interferometric network includes at least one optical switch, at least one birefringent material and at least one polarization element, and a photon detector for detecting time-of-arrival of photons output from the temporal interferometric network to measure the state of the photons
A photoresin formulation for volumetric additive manufacturing contains a photo-curable mixture of: a monomer (e.g., an acrylate-based monomer); a photoinitiator; a polymerization inhibitor (e.g., molecular oxygen (O2)); and, a reducing agent reactive with a free radical species (e.g., a peroxyl radical) formed from the polymerization inhibitor. The reducing agent permits faster printing of objects from the photoresin formulation in a volumetric additive manufacturing process to produce 3D objects of high fidelity.
C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
B33Y 80/00 - Products made by additive manufacturing
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
3.
TGF-B-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF
The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-β) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
Provided is an adjuvant composition comprising a glycoarchaeol and at least one immunostimulantselected from a Toll-like receptor (TLR) agonist and a saponin. The glycoarchaeol and/orimmunostimulant may be present as a pharmaceutically acceptable salt. The adjuvant compositionmay be comprised together with an antigen in an immunogenic composition, such as a vaccine composition, which may be for use to induce an immune response in a subject. Further provided isuse of the immunogenic composition to induce an immune response in a subject, particularly animmune response that comprises both a cell-mediated response and a humoral response.
The present disclosure relates to a single domain antibody that specifically binds to the epitope in the catalytic domain of carbonic anhydrase IX (CA-IX). The single domain antibody has a dissociation constant (KD) of 1×10−7 or lower for a monomeric form of human CA-IX and/or a dimeric form of human CA-IX.
AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A system for forming an object having a three-dimensional structure, the system comprising: a container for providing a photo-curable material to be polymerized; a rotatable stage for supporting the container; a light source for providing light rays having at least one light pattern to be guided into the container via an optical assembly; a processing unit for determining the light source's degree of non-telecentricity, and determining an optimally pre-distorted set of the at least one light pattern based on at least the photo-curable material's refractive index; correcting at least one distortion of the light rays caused by refraction at the container interface and/or correcting at least one distortion of the light rays caused by non-telecentricity; and whereby the correction of the at least one distortion of the light rays is performed without altering the calibration of the optical assembly.
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
Described are various embodiments of an ultrasonic structural health monitoring device, system and method. In one embodiment, an ultrasonic structural health monitoring device is described to monitor a structure. The device comprises a bottom electrode disposable on the structure; a piezoelectric medium disposed on the bottom electrode; a top electrode disposed on the piezoelectric medium; an acoustic insulation layer; and a connector to bring electrical excitation for the piezoelectric medium and to collect a generated electric response therefrom representative of structural health.
Instituto Nacional de Tecnologia Agropecuaria (Argentina)
National Research Council of Canada (Canada)
Inventor
Mignaqui, Ana Clara
Wigodorovitz, Andres
Durocher, Yves
Abstract
Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.
A device and method of fabricating a device having depletion-mode and enhancement-mode high-electron-mobility transistors (HEMTs) on a single wafer are disclosed. The method of fabrication involves providing semiconductor layers capable of sustaining a two-dimensional electron sheet to enable electrical current to flow through the HEMT, forming a series of trenches and fins in the semiconductor layers over an active area of the semiconductor layers on which a gate contact terminal is to be set down, the fins of respective HEMTs having different widths resulting in different voltage thresholds for the respective depletion-mode HEMTs.
H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
A method and apparatus are provided for effecting an RFID-based finger input sensing system using a transmission line connected to at least two RFID tags, by analyzing a plurality of features relating to the number of spikes in the derivatives of the RSS, timing of maximum RSS and the spikes of the RSS derivatives, relative RSS magnitude between the at least two RFID tags, and increase/decrease trend of the RSS, thereby eliminating the need for calibration and training.
G06F 3/046 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means by electromagnetic means
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
G06F 3/0488 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser using a touch-screen or digitiser, e.g. input of commands through traced gestures
A method and apparatus for inscribing a high-temperature stable Bragg grating in an optical waveguide, comprising the steps of: providing the optical waveguide; providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 micrometers (μm); providing cylindrical focusing optics; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intensive to cause permanent (Type II) change in the index of refraction within multiple Bragg grating planes in the core of the optical waveguide resulting from at least one micropore.
G01D 5/353 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
The use of an unctuous sealing material (high viscosity liquid bordering on, or having, solid behavior at low shear forces) for sealing open pore, highly crushable suction cups allows for increased surface conformation for fast secure vacuum gripping, and maintenance of the pressure differential with lower energy in view of the seal. Furthermore, fast grasping is demonstrated if the unctuous sealing material protrudes from the lip.
There is provided a biosensor for detecting water contaminants. The biosensor has a microbial fuel cell compartment, having (i) at least one opening to allow water into and out of the microbial fuel cell compartment, (ii) an anode comprising electroactive microorganisms, and (iii) a cathode. The anode is electrically and physically separated from the cathode. The anode is anaerobic and comprises electroactive microorganisms. The cathode is aerobic. The biosensor has a storage compartment housing a biodegradable carbon source to supply the biodegradable carbon source to the electroactive microorganisms; an electric impedance load; an electric switch forming an intermittent connection between the microbial fuel cell compartment and the electric impedance load; an electric sensor; and a control system coupled to the electric switch and the electric sensor, receiving a measurement from the electric sensor, and outputting an indication signaling the presence or absence of the water contaminants based on the measurement.
The present invention provides an efficient quantum memory for storing a quantum state of light, such as a photon, for a temporary period of time in a fibre-integrated optical cavity and then recall the quantum state of light and quantum information at a later time with a high probability of success. The present invention uses a nonlinear optical switching mechanism to modify at least one property of the quantum light, or cavity, to trap the quantum light in the optical cavity. Subsequent application of the nonlinear optical switching mechanism switches at least one property of the stored quantum light, or cavity, to release the quantum light from the optical cavity. The present invention also provides quasi-deterministic single-photon generation by temporal multiplexing of a photon pair source integrated within the cavity.
A device and method of fabricating a device having a plurality of depletion-mode high-electron-mobility transistors (HEMTs) on a single wafer are disclosed. The method of fabrication involves providing semiconductor layers capable of sustaining a two-dimensional electron sheet to enable electrical current to flow through the HEMT, forming a series of trenches and fins in the semiconductor layers over an active area of the semiconductor layers on which a gate contact terminal is to be set down, the fins of respective HEMTs having different widths resulting in different voltage thresholds for the respective depletion-mode HEMTs.
An example semiconductor device includes: a first layer comprising a first semiconductor material; a second layer comprising a second semiconductor material; and an interface region disposed between the first layer and the second layer and corresponding to an expected depletion region of an interface between the first semiconductor material and the second semiconductor material, the interface region comprising a gradation from the first semiconductor material to the second semiconductor material; and wherein the interface region is configured to reduce Shockley-Read-Hall recombination in the semiconductor device.
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 31/0304 - Inorganic materials including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
Cellulose particles treated with a bio-based surfactant can be compounded into a polymer composite having improved mechanical properties, such as tensile strength and/or tensile modulus. Treatment can be integrated into an industrial scale continuous cellulose particle production process, and the process provides one or more of reduced environmental impact, reduced energy consumption, reduced chemical consumption, reduced water consumption, reduced processing/operational cost, reduced capital investment, increased output, improved fiber dispersion in the polymer matrix and improved thermal degradation properties of the composite.
There is provided a method for fabricating a corrugated buried heterostructure laser, including patterning a dielectric layer coating a substrate having a <0-11> direction to obtain a hollow corrugated structure. The hollow corrugated structure includes a central portion and regularly spaced-apart tabs laterally extending from the central portion and aligned with the <0-11> direction. The method also includes, in a single metal organic chemical vapour deposition run, forming an active region in the hollow corrugated structure to obtain the corrugated buried heterostructure laser. The single run combines selective area growth, p-dopant diffusion and etching techniques. There is also provided a corrugated buried heterostructure laser including a substrate having a <0-11> direction, a corrugated structure defined in the substrate and including a central portion and regularly spaced-apart tabs laterally extending from the central portion and aligned with the <0-11> direction, and an active region grown in the corrugated structure.
There are provided compositions and methods for lyophilization and/or storage of live vaccine strains of Francisella tularensis. More specifically, there are provided lyophilization media and uses thereof for the preparation and long-term storage of Francisella tularensis vaccines.
An electrical machine, which may be a motor and/or a generator has a rotor mounted to rotate about an axis. A plurality of magnetic poles are spaced circumferentially around the rotor in the bore. The rotor comprises a shell shaped to provide a toroidal bore centered on the axis. A slit extends circumferentially around the rotor. The slit penetrates through the shell into the bore. The electrical machine also includes a stator that is supported in the bore by one or more supports extending through the slit of the rotor. The stator carries plural windings that are spaced apart around the bore.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles located in at least a portion of the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
The present disclosure relates to methods and systems for realization of a reference pressure as well as calibration of devices under test. The techniques leverage the measurement of buoyancy artifacts under vacuum and pressure conditions, and the use of gas law equations and related variables to obtain low uncertainty reference values for pressure among others. The techniques can include measuring an absolute mass difference of buoyancy artifacts under vacuum; measuring effective masses of the buoyancy artifacts under a gas pressure condition, and determining an effective mass difference between the buoyancy artifacts; and determining a low-uncertainty pressure based on the absolute mass difference, effective mass difference, Boltzmann constant, volume difference, molecular weight of the gas at pressure, and temperature of the measurements.
A heterostructure laser is provided comprising an epitaxially grown substrate of first dopant type, an active region and layer of second dopant type, a narrow mesa having less than 20% open area and a side wall slope of less than 85 degrees, wherein said narrow mesa is etched through the active region and layer of second dopant type using in-situ MOCVD, a plurality of current blocking layers, an overclad layer and a contact layer of second dopant type, and an isolation mesa incorporating the narrow mesa, wherein the isolation mesa is etched through the active region, layer of second dopant type and plurality of current blocking layers and wherein the plurality of current blocking layers is grown without exposure to oxygen.
A DC-DC converter for converting a low voltage DC input to a higher voltage DC output, the DC-DC converter comprising: an oscillator comprising a first relatively voltage sensitive and relatively low power transistor and a second relatively voltage insensitive and relatively high power transistor, the oscillator producing an AC signal from the low voltage DC input; a first transformer for converting the AC signal produced by the oscillator to a higher voltage AC signal; an autonomous, synchronous voltage-doubling rectification circuit for converting the higher voltage AC signal to the higher voltage DC output, wherein the autonomous, synchronous voltage-doubling rectification circuit comprises a second transformer, a first shunt switch and a second shunt switch; and wherein current through the second transformer controls the synchronous rectification.
H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
26.
Systems and methods for the production of diphtheria toxin polypeptides
An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
C07K 14/34 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
C12N 15/90 - Stable introduction of foreign DNA into chromosome
27.
PHASE-SHIFTED FIBER BRAGG GRATING SENSOR AND METHOD FOR PRODUCING SAME
T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
28.
MESA AVALANCHE PHOTODIODE WITH SIDEWALL PASSIVATION
A mesa-type avalanche photodiode comprising a first mesa of n-type material, a second mesa having an active region, and a third mesa of p-type material, wherein the second mesa includes a p-type sidewall formed by Zn diffusion for suppressing sidewall leakage current.
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
H01L 31/0304 - Inorganic materials including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 31/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof - Details
29.
LAMINATED ARMOR MATERIALS FOR ENHANCED BALLISTIC PROTECTION
The present disclosure relates to laminated armor materials for enhanced ballistic protection. In particular, the present disclosure relates to laminated armor materials comprising first and second armor materials and a laminated adhesive layer comprising nanomaterial fillers.
F41H 5/04 - Plate construction composed of more than one layer
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 3/14 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material characterised by a face layer formed of separate pieces of material
B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
30.
PIEZOCERAMIC PASTES WITH HIGH CERAMIC CONTENT AND METHOD FOR PRINTING SAME
The present disclosure is directed towards a formulation for piezoelectric materials. The formulation may be printed including 2D or 3D printing. The formulation contains ceramic particles, a sol-gel, a high boiling point solvent and a binder.
An electrochemical device is disclosed, which may include an anode, a cathode, and a molded electrolyte composition disposed between the anode and the cathode. Implementations of the electrochemical device may include where the cathode and/or the anode are disposed in a stacked geometry. The electrolyte composition may include a gel polymer electrolyte, which can include a hydrogel of a copolymer and a salt dispersed in the hydrogel of a copolymer. The electrolyte composition may alternatively include a crosslinker or a photoinitiator. A method of producing an electrolyte layer of an electrochemical device is also disclosed, including preparing a substrate having an electrode for an electrochemical device, preparing a gasket to form a cavity on the substrate for the electrolyte layer, and depositing an electrolyte composition onto the substrate
H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
32.
FUSION PROTEIN COMPRISING A BLOOD-BRAIN BARRIER (BBB)-CROSSING SINGLE DOMAIN ANTIBODY FC5, AN IMMUNOGLOBULIN FC FRAGMENT AND A BETA-AMYLOID BINDING POLYPEPTIDE (ABP)
A brain-penetrating composition of amyloid-β binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-β targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
A61K 9/00 - Medicinal preparations characterised by special physical form
An interface device for performing off-chip coupling in optical waveguides includes an optical waveguide core for propagating light of a particular wavelength or a plurality of wavelengths and an array of radiative elements configured to change the propagation direction of the light. The optical waveguide core is configured to control the effective refractive index of the propagation mode of the light. The device can thus serve as an optical antenna for coupling between a waveguide mode and a free-space propagating beam or a plurality of free-space propagating beams in an arrayed configuration.
A computer-implemented method for detecting attribute value pairs from corpus data using a computer comprising a processor and a computer readable medium comprising instructions executable by the processor to at least: receive the corpus data comprising at least one pair; detect a layout template of the at least one pair; measure the merit of the layout template by determining at least one of (a) relative magnitudes of content probabilities based on a probability of the contents of an attribute cell and a probability of a corresponding value cell, (b) the validity of a name-value pair, or (c) the pointwise mutual information of a frequency matrix M corresponding to a sparse vector capturing context information of a word; and output detected attribute value pairs.
A composite material suitable for use in sensing and catalysis applications with conjugated polymers non-covalently bound to the carbon nanotubes. The conjugated polymers have alternating aromatic (Ar) units and bipyridine (BPy) units. Metal nanoparticles having a size that is between about 0.3 nm and about 5 nm are bound to the conjugated polymers at respective BPy units, thereby anchoring the metal nanoparticles to the carbon nanotubes. Thus, a metal salt solution was added into the polymer/carbon nanotube solution to form a metal-BPy complex, which is in situ photo reduced to metal nanoparticles. Therefore, the formed nanoparticles are tightly anchored to the nanotube and can be self-regenerated by room light to offer the material a high performance and durability.
A laser comprising a narrow linewidth, comprising: a grating along a laser cavity; a laser waveguide having a plurality of waveguide sections corresponding to a plurality of grating sections, each of the plurality of waveguide sections having a ridge/mesa width for detuning the grating in each of the plurality of grating sections; and a plurality of contact electrodes contacting each of the plurality of waveguide sections, the plurality of contact electrodes for applying a different current to each of the plurality of waveguide sections to enable active feedback noise suppression.
H01S 5/22 - Structure or shape of the semiconductor body to guide the optical wave having a ridge or a stripe structure
H01S 5/10 - Construction or shape of the optical resonator
H01S 5/0625 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes in multi-section lasers
37.
ANTI-CD22 SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC CONSTRUCTS
Herein are provided anti-CD22 single domain antibodies (sdAb) prepared by immunizing a llama with the extracellular domain of the predominant human CD22 isoform. By constructing a library of the heavy chain repertoire generated, VHH antibodies specific to the immunogen were isolated. The 27 example antibodies initially produced comprise CDR1, CDR2, and CDR3 sequences corresponding, respectively to SEQNOs: 1-3, 4-6, 7-9, 10-12, 13-15, 16- 18, 19-21, 22-24, 25-27, 28-30, 31-33, 34-36, 37-39, 40-42, 43-45, 46-48, 49-51, 52-54, 55- 57, 58-60, 61-63, 64-66, 67-69, 70-72, 73-75, 75-78, and 79-81; and related sequences. Also provided are multivalent antibodies comprising any one of the sdAbs, including bispecific T-cell engagers, bispecific killer cell engagers (BiKEs), and trispecific killer cell engagers (TriKEs). Also described are chimeric antigen receptors (CARs) for CAR-T therapy comprising any one of the aforementioned sdAbs. Uses of these molecules in the treatment of cancer are also described.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
An example system for co-liquefying feedstock and yellow grease includes: a feedstock container to contain a feedstock; a yellow grease container to contain a yellow grease; a hydrothermal liquefaction system configured to receive feedstock from the feedstock container and to receive yellow grease from the yellow grease container; the feedstock received by the hydrothermal liquefaction system and the yellow grease received by the hydrothermal liquefaction system to become a mixture; a controller connected to the feedstock container and the yellow grease container, the controller configured to control the amount of the feedstock supplied from the feedstock container to the hydrothermal liquefaction system, the controller further configured to control the amount of the yellow grease supplied from the yellow grease container to the hydrothermal liquefaction system to be between 10% to 50% of the mixture; and a collector configured to receive a bio-crude from the hydrothermal liquefaction system.
C10G 1/00 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal
39.
BLOOD-BRAIN BARRIER TRANSMIGRATING COMPOUNDS AND USES THEREOF
A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
An antenna device for performing off-chip light coupling comprising an array of radiating elements whose thickness is larger than λ/2, the radiating elements being chosen such that the length of the array is smaller than 10λ, where λ is the wavelength of light in the material chosen for the radiating elements. An advantage of this method is that, unlike in conventional waveguide grating antenna, by reducing the number of the radiating elements in the array, the dependence of the off-chip emission angle on the wavelength of light can be greatly reduced. Another advantage is that by using thick radiating elements the antenna efficiency can be greatly enhanced, thereby compensating for the reduced efficiency occurring as a consequence of using only a small number of radiating elements in the array.
The present application relates to methods of preparing a coated substrate and coated substrates which can be optionally prepared from such methods. The methods comprise depositing on the substrate a single abrasion resistant layer by magnetron sputtering or depositing on the substrate a dual layer comprising a first abrasion resistant layer deposited by magnetron sputtering and a second abrasion resistant layer deposited by plasma-enhanced chemical vapor deposition.
C23C 28/04 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and only coatings of inorganic non-metallic material
C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
C23C 16/50 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating using electric discharges
A method of monitoring both liner wear and charge impact in an industrial mill uses a sensor mounted on an elongated element deployed through a shell into a liner of the mill. The elongated element wears at a same rate as the liner under conditions within the shell. Liner wear is related to a reduction in length of the elongated element as measured by travel time of an ultrasound wave, while location and strength of charge impact is related to change in amplitude of vibrations caused by the charge impact. Liner wear measurement can be improved by using shear ultrasound waves instead of conventional longitudinal ultrasound waves. A mill monitoring apparatus has a means for acquiring ultrasonic waves and audible sound waves using the same digitizer; a means for determining the angular position of the monitoring apparatus; and a means for supplying electric power to the apparatus.
B02C 17/18 - Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls - Details
A method of fabricating a conductive yarn comprising a plurality of filaments, the method comprising the steps of: (a) applying a reducing agent solution to the treated surface; and (b) applying a metal ion solution to the treated at least one of the lurality of filaments. The method comprising a further step of treating the surface of the at least one of the plurality of filaments with a hydrophilic agent before performing steps (a) and (b).
D06M 11/83 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys
A coated electrode assembly (CEA) comprising: i) a gas diffusion layer (GDE); and ii) a coating. The GDE comprises a gas diffusion layer (GDL) and a catalyst layer. The catalyst layer is disposed between the coating and the GDL. The catalyst layer comprises a hydrophobic polymer and/or an ionomeric polymer and the coating comprises a hydrophobic polymer and/or an ionomeric polymer. A method for making a CEA is provided. The CEA may have improved performance and stability compared to a membrane electrode assembly (MEA).
C25B 11/056 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of textile or non-woven fabric
C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
C25B 11/053 - Electrodes comprising one or more electrocatalytic coatings on a substrate characterised by multilayer electrocatalytic coatings
C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
45.
THERMALLY CURABLE PIEZOELECTRIC COMPOSITES AND USE THEREOF IN ADDITIVE MANUFACTURING
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles and a polymer material comprising at least one thermoplastic polymer and at least one thermally curable polymer precursor. At a sufficient temperature, the at least one thermally curable polymer precursor may undergo a reaction, optionally also undergoing a reaction with the piezoelectric particles, and form an at least partially cured printed part. The piezoelectric particles may be mixed with the polymer material and remain substantially non-agglomerated when combined with the polymer material. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste, which may be utilized in forming printed part by extrusion, layer-by-layer deposition, and thermal curing.
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
A deformable minor system comprising: a deformable mirror surface; a plurality of actuators coupled to the mirror surface to deform the minor surface; and a detector coupled to the actuators to detect, for each actuator, an output signal from a driver of the actuator; and a controller coupled to each of the plurality of actuators, wherein the controller is configured, for each actuator, to: add a test signal to an input signal to form a modified input signal; send the modified input signal to the actuator; receive an indication of the output signal from the driver; determine when a test signal portion of the output signal satisfies a threshold condition; and in response to the test signal portion satisfying the threshold condition, control a subset of adjacent actuators to execute a shutdown sequence.
G01M 11/00 - Testing of optical apparatus; Testing structures by optical methods not otherwise provided for
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
47.
ULTRAFAST TEMPORAL FILTERING FOR QUANTUM COMMUNICATIONS
A quantum communication method comprising: at a sender, preparing photons encoded in a single spatial, spectral, and temporal (SST) mode to form a quantum signal; and introducing the quantum signal into a quantum channel; at a receiver, a detector and filtering system optically processing the quantum signal and rejecting background noise photons in the quantum channel, and performing active temporal filtering by switching the polarization of the quantum signal without substantially adding noise; and wherein the active temporal filtering minimizes saturation of the detector.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions that are extrudable and comprise a plurality of piezoelectric particles and a plurality of carbon nanomaterials dispersed in at least a portion of a polymer material. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further containing at least one polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
C09D 167/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
H10N 30/85 - Piezoelectric or electrostrictive active materials
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (µm); providing cylindrical focusing optics corrected for spherical aberration; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.
A method for detecting and identifying a remote gas, the method comprising the steps of: receiving a light wave associated with the remote gas; coupling the light wave into a single mode fibre; transmitting the light wave via the single mode fibre into a filter comprising a fibre-based tunable cavity; modulating the cavity length of the filter transmission window to cause a detected modulated signal that is proportional to the spectral feature; and processing the signal using a lock-in amplifier capable of low-pass filtering and out-of-frequency noise rejection.
A forming tool with forced thermal fluid-based spatio-temporal temperature control of a surface of the tool has a subsurface manifold underlying at least a part of a forming surface of the tool and a number P of at least 6 ports, each port fluid coupled respectively to the manifold via respective channels, where the ports exit the tool at disparate points, with each pair of ports in fluid communication via the manifold. This structure allows manifold path diversity for varying thermal fluid supply and drainage. The manifold may be reinforced.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles dispersed in at least a portion of a polymer matrix comprising first polymer material and a sacrificial material, the sacrificial material being removable from the polymer matrix to define a plurality of pores in the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The sacrificial material may comprise a second polymer material. The compositions may define a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer and introducing porosity therein.
Methods and systems for determining a change in condition of a rock bolt. Some methods may comprise, at a first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a first time of flight for each of the shear and longitudinal waves, at a second point in time after the first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a second time of flight for each of the shear and longitudinal waves, and using the relative changes of the first and second time of flights, determining the change in condition of the rock bolt section.
A semiconductor high electron mobility transistor (HEMT)-based device configured to detect ionizing radiation, wherein the device comprises: a substrate; a nucleation layer formed on the substrate; a gallium nitride (GaN) buffer layer arranged on the nucleation layer; a GaN channel layer arranged on the GaN buffer layer; an aluminum nitride (A1N) spacer layer arranged on the GaN channel layer; a barrier layer arranged on the A1N spacer layer; a GaN cap layer arranged on the barrier layer; an electrically insulating silicon nitride (SiNx) passivation layer arranged on the GaN cap layer; a source, a drain and a gate, wherein the source and the drain are formed on the GaN cap layer; wherein charge carriers generated by the radiation in the underlying GaN layers are collected in the GaN channel layer and multiplied by impact ionization by a high electric field at the gate edge facing the drain contact.
H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
55.
Use of Human Resistin as a Trimerization Partner for Expression of Trimeric Proteins
Provided is a recombinant polypeptide comprising a resistin trimerization domain and a polypeptide of interest. Further provided is an expression vector encoding the recombinant polypeptide and a method of expressing the recombinant polypeptide. The polypeptide of interest may be a trimeric viral surface antigen or a portion thereof, such as the ectodomain of the SARS-CoV-2 spike protein. Further provided are compositions, such as immunogenic compositions and vaccines, comprising the recombinant polypeptide.
The present disclosure relates to water-soluble formulations containing cannabinoids. In particular, the formulations comprise at least one isolated cannabinoid, cannabinoid oil or cannabinoid resin, and a solubilizing agent of Formula (I), where the group X is a residue of a hydrophobic moiety selected from sterols, tocopherols, and derivatives thereof, and the group Y is a residue of a hydrophilic moiety selected from polyalcohols, polyethers, and derivatives thereof. In preferred embodiments, the cannabinoid comprises cannabidiol (CBD) or Δ9-tetrahydrocannabinol (THC) and the hydrophobic moiety is polyoxyethanyl-α-tocopheryl sebacate (TPS). In embodiments, the formulations comprise a carrier oil, such as a medium length triglyceride (MCT), and are dispersed in water in the form of micelles.
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer material comprising at least one thermoplastic polymer, and a plurality of piezoelectric covalently bonded to the at least one thermoplastic polymer and dispersed in at least a portion of the polymer material. The compositions are extrudable and may be pre-formed into a form factor suitable for extrusion. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
58.
PIEZOELECTRIC COMPOSITES FEATURING NONCOVALENT INTERACTIONS AND USE THEREOF IN ADDITIVE MANUFACTURING
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles non-covalently interacting with at least a portion of a polymer material via π-π bonding, hydrogen bonding, electrostatic interactions stronger than van der Waals interactions, or any combination thereof. The piezoelectric particles may be dispersed in the polymer material and remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further including a polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles substantially localized in one of the first polymer material or the second polymer material. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles and a polymer material comprising at least one thermoplastic polymer and at least one photocurable polymer precursor. The at least one photocurable polymer precursor may undergo a reaction in the presence of electromagnetic radiation, optionally undergoing a reaction with the piezoelectric particles, in the course of forming the printed part. The piezoelectric particles may be mixed with the polymer material and remain substantially non-agglomerated when combined with the polymer material. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste, which may be utilized in forming printed parts by extrusion and layer-by-layer deposition, followed by curing.
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles located in a polymer matrix comprising a first polymer material and a sacrificial material that are immiscible with each other. The sacrificial material, which may comprise a second polymer material, may be removable from the first polymer material under specified conditions. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The polymer matrix may be treated to remove the sacrificial material to introduce a plurality of pores. The compositions may have a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector, wherein the Salmonella typhi vector has been engineered to express one or more antigens; an outer membrane folding protein Barn A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella typhi vector is capable of delivering the antigen to a mucosal tissue via an outer membrane vesicle when administered to a subject.
An example short-wave infrared imaging device includes: a detector to detect light representing an object to be imaged, the detector comprising a semiconductor wafer divided into an array of detector cells; and an image processor coupled to the detector to generate image data based on the reflected light detected at the detector; and wherein each detector cell comprises: a detection region of the semiconductor wafer; a dopant doped into the wafer in a sub-cell pattern having at least two spaced apart doped regions, the dopant to generate a signal based on light received in the detection region of the detector cell; a metal contact joining the at least two doped regions; and a signal processing circuit coupled to the metal contact to transmit the signal to the image processor.
A valve assembly for resin transfer molding is provided. The valve assembly includes an inlet positioned to receive a fluid. The valve assembly additionally includes a valve shaft positioned to receive the fluid from the inlet. The valve assembly further includes an outlet positioned to receive the fluid from the inlet. The valve assembly also includes an injection port positioned to receive the fluid from the valve shaft. The valve assembly also includes a piston configured to move coaxially within the valve shaft, such that the fluid is delivered from the inlet to the outlet when the piston is in a first position, and the fluid is delivered from the inlet to the injection port when the piston is in a second position.
B29C 70/54 - Component parts, details or accessories; Auxiliary operations
B29C 70/48 - Shaping or impregnating by compression for producing articles of definite length, i.e. discrete articles using matched moulds, e.g. for deforming sheet moulding compounds [SMC] or prepregs and impregnating the reinforcements in the closed mould, e.g. resin transfer moulding [RTM]
65.
Lithography for editable atomic-scale devices and memories
The Governors of the University of Alberta (Canada)
Inventor
Achal, Roshan
Wolkow, Robert A.
Pitters, Jason
Cloutier, Martin
Rashidi, Mohammad
Taucer, Marco
Huff, Taleana
Abstract
An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.
G11C 16/04 - Erasable programmable read-only memories electrically programmable using variable threshold transistors, e.g. FAMOS
G11C 11/44 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using super-conductive elements, e.g. cryotron
An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.
G01P 15/093 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values by photoelectric pick-up
67.
FULL CONTROL OF POLARISATION IN FIBRE DELIVERED LIGHT FOR HARSH ENVIRONMENTS
A method of transmitting information comprising the steps of: (a) transmitting at least one photon via a fibre; (b) characterizing the fibre by determining at least one depolarization loss caused by the fibre; and (c) compensating for polarization altering effects of the fibre; wherein a single photon source is used for delivery of individual polarized photons in harsh environments.
H04B 10/2569 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion due to polarisation mode dispersion [PMD]
H04B 10/2525 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion due to chromatic dispersion using dispersion-compensating fibres
68.
METHODS AND SYSTEMS FOR LEARNING ONLINE TO PREDICT TIME-SERIES DATA
The present invention relates to methods and systems for learning online to predict time-series data. More specifically, the present invention discloses a system that takes at least one time-varying signal as input, and use a model with an adjustable set of parameters to predict the future values of this time-varying signal as output. The system maintains a compressed representation of the history of its predicted output values, and a learning rule is used to compute an update to the system's parameters so as to reduce any discrepancy between the current value of the time varying signal and all previous predictions for this value that are stored in the compressed representation. The system is operated to perform at least one robotic control, pattern classification, signal processing, or data generation task that is improved by predicting the future values of a time-varying input signal.
A technique for detection of probes in a microfluidic flow-through chamber involves a plurality of interface pinning reaction vessel formed by micro- or nano-structured relief patterning of a substrate. The relief patterning increases a surface area locally, and defines a plurality of separated interface pinning reaction vessels. The marked detection protocol may be supplied on a single layer of a stacked microfluidic chip, or the chamber may constitute a whole layer. The chip may be designed to be driven mechanically, pneumatically, hydraulically, centrifugally or by capillary action. Each vessel allows for a high density of probes, an effective region for developer-type or fluorescence-based marking, and efficient readout. Suitable probe liquids can be self-limiting to fill one vessel. Suitable developer liquids avoid dye bleeding across vessels during washing.
The present application relates to compositions corn-sing a bioactive lipophilic compound, an oil and at least one solubilizing agent that is a compound of Formula (I), to emulsions comprising such compositions and to uses thereof. The present application also relates to methods of preparing such emulsions. The methods comprise heating such compositions to form a homogeneous melt and combining the homogeneous melt with water to obtain the emulsion.
A61K 47/44 - Oils, fats or waxes according to two or more groups of ; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A23L 33/115 - Fatty acids or derivatives thereof; Fats or oils
A tag detection system comprising a source for producing an interrogation signal having a first frequency; a harmonic radar tag comprising: an antenna structure; a tunneling junction electrically and integrally coupled to the antenna; and wherein the harmonic radar tag when stimulated by the interrogation signal having the first frequency, and the harmonic radar tag produces a response signal at a second frequency different from the first frequency.
Functional and/or functional precursor products, formulations for making the products, methods of making the products (e.g. functional coatings, concentrated gradients, and/or composites), and uses thereof are provided. In an aspect, the method comprises a) combining at least one first polymerizable component and at least one second polymerizable component to form a composition; and b) polymerizing the at least one first polymerizable component to form at least one first polymer structure, wherein at least two phases are formed from the at least one first polymer structure and the at least one second polymerizable component, and wherein the product is a functional product, a functional precursor product, or a combination of a functional and functional precursor product.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29D 11/00 - Producing optical elements, e.g. lenses or prisms
B33Y 80/00 - Products made by additive manufacturing
An ohmic contact includes a first semiconductor layer a second semiconductor layer, and a heterointerface between the first semiconductor layer and the second semiconductor layer. The second semiconductor layer has a two-dimensional electron sheet region in which a two-dimensional electron sheet is formed. The ohmic contact further includes a metal terminal covering the first semiconductor layer and filling a plurality of direct access pathways that provide direct lateral contact with the two-dimensional electron sheet region. The semiconductor device is fabricated by providing the semiconductor layers, etching the direct access pathways, and depositing metal material to fill the direct access pathways and cover the semiconductor layers. The ohmic contact may be part of a high-electron-mobility transistor that achieves low contact resistance with either no annealing at all (as-deposited metal), or at an anneal temperature that is much lower than industry-standard anneal temperatures to achieve sufficiently low contact resistance.
H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
H01L 21/285 - Deposition of conductive or insulating materials for electrodes from a gas or vapour, e.g. condensation
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/205 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds including two or more compounds in different semiconductor regions
There is provided a method for fabricating a vertically tapered spot-size converter on a substrate, comprising: growing a waveguide core on the substrate; coating the waveguide core with a photoresist layer; placing a photomask having patterns at a negative focus offset point with respect to the photoresist layer, the patterns being defined by openings in the photomask, each opening having a cross-section comprising a region of constant width and at least one region of non-constant width, the non-constant width reducing in a direction extending away from the region of constant width; transferring the patterns of the photomask to the photoresist layer; providing the waveguide core with a vertically tapered profile, the vertically tapered profile being provided by the patterns of the photomask; growing a cladding layer over the waveguide core; and patterning and etching the cladding layer and the waveguide core, thereby defining the vertically tapered spot-size converter.
G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
75.
BURIED HETEROSTRUCTURE SEMICONDUCTOR OPTICAL AMPLIFIER AND METHOD FOR FABRICATING THE SAME
A method for fabricating a buried heterostructure semiconductor optical amplifier is provided. The method includes a step providing a patterned dielectric layer on a substrate, the patterned dielectric layer having openings to expose uncovered regions of the substrate. The method also includes, in a single metal organic chemical vapour deposition (MOCVD) run: etching the uncovered regions of the substrate to form angles at corresponding edges thereof and diffusing a p-dopant in the substrate to obtain a p-dopant distribution in a portion of the substrate; etching a portion of the p-dopant thereby defining a recess in the substrate and growing a n-blocking layer in the recess; sequentially growing, over a portion of the n-blocking layer, an active region, a p-overclad, a p-contact, and a p-metal contact; and growing a n-metal contact on a backside of the substrate. The single MOCVD run combines selective area growth, p-dopant diffusion and etching techniques.
H01S 5/343 - Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser
H01S 5/22 - Structure or shape of the semiconductor body to guide the optical wave having a ridge or a stripe structure
H01S 5/30 - Structure or shape of the active region; Materials used for the active region
76.
METHODS OF MANUFACTURING PERMANENT MAGNETS BY ADDITIVE MANUFACTURING
The present disclosure is directed towards a method of manufacturing a permanent magnet such that the magnet defines a channel for allowing circulation of a coolant through the permanent magnet, or defines a channel for allowing circulation of the coolant through an interface between the permanent magnet and a substrate. Magnets made by this method may be useful for manufacturing and/or operating a machine, such as a motor, engine, or sensor.
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
H01F 1/057 - Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5 and IIIa elements, e.g. Nd2Fe14B
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
An antenna and a formulation and method for making the antenna are disclosed. The antenna comprises: a first phase comprising at least one polymer; a second phase comprising at least one first component; and, optionally; and an interface between the first and second phases, wherein the interface has a concentration gradient of the at least one first component, whereby the concentration of the at least one first component decreases with distance away from the second phase towards the first phase, wherein the at least one first component comprises at least one functional component, at least one functional precursor component, or combinations thereof, and the at least one first component, in combination with the at least one polymer, has a high dielectric constant and/or a low dielectric loss tangent, wherein the antenna is a functional antenna, a functional precursor antenna, or a combination of a functional and functional precursor antenna.
H01Q 1/40 - Radiating elements coated with, or embedded in, protective material
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29D 11/00 - Producing optical elements, e.g. lenses or prisms
G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
A method for timing aperture synthesis arrays comprising the steps of: (a) coupling a plurality of independent crystal oscillators, each of the plurality of independent crystal oscillators having a unique output frequency; (b) digitally synchronizing the plurality of independent crystal oscillators in phase; (c) combining the unique output frequencies; and (d) obtaining a stable digital reference signal for timing at least one remote radio device of the aperture synthesis array.
H03L 7/099 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
H03L 7/24 - Automatic control of frequency or phase; Synchronisation using a reference signal directly applied to the generator
H03L 7/14 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop for assuring constant frequency when supply or correction voltages fail
79.
Viral Origin of Replication to Increase Protein Productivity from Mammalian Cells
The present disclosure relates to the use of an Epstein Barr virus origin of replication (oriP) or a functional fragment thereof in a protein expression construct to increase production of a protein of interest in mammalian cells. Also disclosed are protein expression constructs for increased production of antibodies in mammalian cells, and mammalian cells containing the expression constructs.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
80.
ENHANCEMENT-MODE HIGH ELECTRON MOBILITY TRANSISTORS WITH SMALL FIN ISOLATION FEATURES
An enhancement-mode high-electron-mobility transistor (HEMT) having small fin isolation features and methods of fabrication thereof are disclosed. The method of fabrication involves providing semiconductor layers capable of sustaining a two-dimensional electron sheet to enable electrical current to flow through the HEMT, forming a series of trenches and fins in the semiconductor layers over an active area of the semiconductor layers on which a gate contact terminal is to be set down, the fins having widths equal to or less than about 30 nm across, and setting down the gate contact terminal across the fins.
H01L 21/8252 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices to produce devices, e.g. integrated circuits, each consisting of a plurality of components the substrate being a semiconductor, using III-V technology
A biodegradable solid aqueous electrolyte composition, an electrochemical device incorporating the electrolyte composition, and methods for the same are provided. The electrolyte composition may include a hydrogel of a copolymer and a salt dispersed in the hydrogel. The copolymer may include at least two polycaprolactone chains attached to a polymeric center block. The electrochemical device may include an anode, a cathode, and the electrolyte composition disposed between the anode and the cathode. The electrolyte composition may include a crosslinked, biodegradable polymeric material that is radiatively curable prior to being crosslinked.
A centrifugal microfluidic technique for heat treating emulsion-divided independent reaction volumes (IRVs) within a centrifugal microfluidic chip, and displacing the emulsion into a monolayer presentation chamber (pc) for imaging. A deep treatment chamber (tc) is provided for the heat treatment, a nozzle having a hydrodynamic radius for forming the IRVs is provided for injecting a sample for the IRVs into the tc filled with a dense immiscible medium. The tc is adjacent a heat controlled element for collectively heat treating the IRVs within the tc, where the IRVs form a 3d packing arrangement. The tc is coupled to a presentation chamber (pc) by an opening through which the IRVs can be selectively displaced without collapsing. The pc is adjacent a window transparent to a wavelength for inspecting the pc.
A 3D printed GRIN device, the formulation and the method for making the GRIN device are disclosed. The GRIN (graded-index) device comprises i) a first phase comprising at least one polymer; ii) a second phase comprising at least one first component; and, optionally, iii) an interface between the first phase and the second phase, wherein the interface has a concentration gradient of the at least one first component, whereby the concentration of the at least one first component decreases with distance away from the second phase towards the first phase, wherein the at least one first component comprises at least one functional component, at least one functional precursor component, or combinations thereof, and wherein the GRIN device is a functional GRIN device, a functional precursor GRIN device, or a combination of a functional and functional precursor GRIN device.
B33Y 80/00 - Products made by additive manufacturing
B29D 11/00 - Producing optical elements, e.g. lenses or prisms
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
84.
Glass-containing pseudo-reference electrode for use in ion-selective electrode sensors and ion selective field-effect transistors
A pseudo-reference electrode comprising a pseudo-reference glass material backed by a silver conductor comprising silver metal, wherein the pseudo-reference glass material is a chalcogenide glass comprising a silver chalcogenide Ag2Ch, wherein Ch denotes a chalcogen, or a halide glass comprising a silver halide and at least one glass-forming oxide of a metal or a metalloid, a mixture of two or more of these glasses, or a composite of at least one of these glasses. This pseudo-reference electrode can be used in ion-selective electrode (ISE) sensors and ion-selective field effect transistors (ISFETs).
B32B 17/06 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
C03C 3/32 - Non-oxide glass compositions, e.g. binary or ternary halides, sulfides, or nitrides of germanium, selenium or tellurium
G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
The present disclosure relates to antigen-binding agents that specifically bind to epidermal growth factor receptor variant III (EGFRvIII). Antigen-binding agents of the present disclosure include antibodies and antigen-binding fragments thereof, chimeric antigen receptors (CARs) and bi-specific T-cell engagers (BITE!), bispecific killer cell engagers (BiKEs) and bispecific killer cell engagers (TriKEs). Nucleic acid molecules and vectors expressing antibodies, antigen-binding fragments, CARs, BiTEs, BiKEs or TriKEs are also encompassed by the present disclosure. Immune cells engineered to express CARs, BiTEs, BiKEs or TriKEs may be used to specifically recognize and kill cells expressing EGFRvIII.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The Governors of the University of Alberta (Canada)
Inventor
Wolkow, Robert A.
Pitters, Jason
Salomons, Mark
Abstract
A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.
H02N 2/02 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing linear motion, e.g. actuators; Linear positioners
A quantum simulation method for solving a computational problem using a solid-state quantum system, the method comprising the steps of: passing a laser through a material; in the material, evolving at least some of a plurality of atoms in a first state into at least some of a plurality of atoms in a second state upon receiving energy from the laser to form at least one exciton; selecting at least one exciton site on the material wherein the at least one exciton site is separated from a neighbouring at least one exciton site by a distance less than a Rydberg blockade radius; mapping the computational problem into a problem Hamiltonian of the solid-state quantum system; measuring at least a portion of plurality of the at least one excitons to obtain a read-out of the solid-state quantum system; and determining a solution to the computational problem from the read-out.
According to an aspect, a rotor for a Synchronous Reluctance Motor (SynRM) is provided. The rotor core includes alternating layers of radially fabricated flux carrier and flux barrier material, defining flux barriers extending through the core without bridges and/or center-posts. In some embodiments, the alternating layers include layers of permanent magnet (PM) and soft magnetic composite (SMC) material fabricated on, and adhered directly to, the rotor shaft. A corresponding method for manufacturing the SynRM is also provided.
A technique for supplying droplet content of an oil-encapsulated (OE) digital microfluidic (DμF) network to a region that is sensitive to oil contact involves sealing off a boundary surrounding the sensitive region with a volume of liquid that is miscible with payload of the OE-droplets. The sensitive region may be an opening to a microfluidic channel, or a sensor surface. The sealing off may be provided by transporting an unencapsulated droplet over the OE-DμF chip, either from a reservoir prior to oil encapsulation of the reservoir, or from a non-oil encapsulated reservoir; or by injecting the liquid into the microfluidic channel. A suitable treatment of the boundary may anchor the liquid to the boundary, and prevent removal by ordinary OE-DμF operations. A remainder of the surfaces of unit cells the DμF chip may provide higher droplet contact angle.
An example device to determine a distance of a target includes: an emitter to emit light pulses according to a device-identifying spatial pattern; a detector to detect light forming an incoming spatial pattern; and a processor interconnected with the emitter and the detector, the processor configured to: determine whether the incoming spatial pattern is valid based on the device-identifying spatial pattern; and when the incoming spatial pattern is valid, determine the distance of the target based on the incoming spatial pattern.
G01S 17/26 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves wherein the transmitted pulses use a frequency-modulated or phase-modulated carrier wave, e.g. for pulse compression of received signals
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
G01S 7/4865 - Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
91.
OHMIC CONTACTS WITH DIRECT ACCESS PATHWAYS TO TWO-DIMENSIONAL ELECTRON SHEETS
An ohmic contact includes a first semiconductor layer a second semiconductor layer, and a heterointerface between the first semiconductor layer and the second semiconductor layer. The second semiconductor layer has a two-dimensional electron sheet region in which a two-dimensional electron sheet is formed. The ohmic contact further includes a metal terminal covering the first semiconductor layer and filling a plurality of direct access pathways that provide direct lateral contact with the two-dimensional electron sheet region. The semiconductor device is fabricated by providing the semiconductor layers, etching the direct access pathways, and depositing metal material to fill the direct access pathways and cover the semiconductor layers. The ohmic contact may be part of a high-electron-mobility transistor that achieves low contact resistance with either no annealing at all (as-deposited metal), or at an anneal temperature that is much lower than industry-standard anneal temperatures to achieve sufficiently low contact resistance.
H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/205 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds including two or more compounds in different semiconductor regions
H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
H01L 21/285 - Deposition of conductive or insulating materials for electrodes from a gas or vapour, e.g. condensation
A centrifugal microfluidic chip is provided that allows an on-chip chamber to provide humidification control, or more generally, gas composition control, to another chamber of the chip. This allows for microfluidic incubation using low-cost and efficient centrifugal devices such as multi-port pneumatic chip controllers, single or multi-port pneumatic slip rings, and articulated centrifugal blades with a pneumatic slip ring. The device may be used for cell culturing, microorganism testing, or production of chemical species from biological samples with a controlled microenvironment.
Devices and methods to perform Raman spectroscopy with a structured excitation profile to obtain a Raman excitation map. A device includes a broadband light source to emit a broadband light beam and excitation optics to disperse the broadband light beam to strike a sample as incident light according to a structured excitation profile. The device further includes analysis optics to collect scattered light scattered by the incident light striking the sample, block Rayleigh scatter from the collected scattered light in a manner complementary to the structured excitation profile, and direct Raman scatter from the collected scattered light to a sensor to generate a signal to form a Raman excitation map.
A solution is provided comprising boron nitride nanotubes (BNNTs) in a liquid solvent. An optical waveguide, such as an optical fiber, is contacted with the solution so as to form a layer of the solution supported on at least a portion of the optical waveguide. The liquid solvent is then removed from the layer of the solution supported on the optical waveguide in order to form a coating of the BNNTs on the optical waveguide. Further provided is a BNNT coated optical waveguide for use as a sensor.
A synthesized grating is provided comprising a substrate/layer, and a plurality of alternating aperiodic non-uniform low and high index profiles on a surface of the substrate/layer defining a transmission/reflection spectrum for one of either single or multi-frequency operation of said grating in an optical cavity. A method is also provided for designing the synthesized grating, comprising determining a grating structure of given profiles through analysis of an optimized weighted sum and mapping the grating profile to said surface with the plurality of alternating non-uniform low and high index profiles. A distributed feedback laser is also provided having top, bottom and two sides, comprising a top electrode, a cladding layer disposed below the top electrode a bottom electrode, a substrate disposed above the bottom electrode, one of either an active or passive waveguide layer, a synthesized aperiodic grating layer providing distributed minors, and wherein the waveguide layer and synthesized aperiodic grating layer are disposed between said the substrate and cladding layer and are separated by a spacer layer.
A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
The present application relates to copolymer-silica hybrid aerogels as well as methods for the preparation thereof. The methods comprise hydrolyzing a silica precursor in an organic solvent to obtain a partially polymerized silica wet gel, reacting the partially polymerized silica wet gel with a copolymer of Formula (II) to obtain a copolymer-silica hybrid wet gel, reacting the copolymer-silica hybrid wet gel with a surface passivation agent and removing solvent from the copolymer-silica hybrid wet gel to obtain the copolymer-silica hybrid aerogel. The mechanical properties of the copolymer-silica hybrid aerogels can be further improved by blending cellulose nanofibrils into the hybrid aerogels. (II)
The present application relates to copolymer-silica hybrid aerogels as well as methods for the preparation thereof. The methods comprise hydrolyzing a silica precursor in an organic solvent to obtain a partially polymerized silica wet gel, reacting the partially polymerized silica wet gel with a copolymer of Formula (II) to obtain a copolymer-silica hybrid wet gel, reacting the copolymer-silica hybrid wet gel with a surface passivation agent and removing solvent from the copolymer-silica hybrid wet gel to obtain the copolymer-silica hybrid aerogel. The mechanical properties of the copolymer-silica hybrid aerogels can be further improved by blending cellulose nanofibrils into the hybrid aerogels. (II)
C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
98.
TGF-β-receptor ectodomain fusion molecules and uses thereof
The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-β) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
An apparatus, method and system are set forth for detection of fluids using Bragg grating sensors, wherein the Bragg grating sensing element comprises an optical fiber having a Bragg grating inscribed therein characterized by optical properties that are dependent upon the periodicity and effective refractive index of the grating, and a package for subjecting the Bragg grating to a change in strain when contacted by a fluid such that periodicity and effective refractive index of the grating changes, whereby when interrogated with laser light any such change in periodicity and effective refractive index may be detected.
patents
