An example sensor includes: at least three capacitive sensing segments applied to the container; and a processor connected to the at least three capacitive sensing segments, the processor configured to: obtain respective capacitance measurements from the at least three capacitive sensing segments; determine an orientation of the container based on the capacitance measurements; and determine the amount of the substance based on the capacitance measurements.
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
G01C 9/20 - Mesure de l'inclinaison, p.ex. par clinomètres, par niveaux en utilisant des liquides l'indication étant basée sur l'inclinaison de la surface d'un liquide par rapport à son récipient
A photoresin formulation for volumetric additive manufacturing contains a photo-curable mixture of: a monomer (e.g., an acrylate-based monomer); a photoinitiator; a polymerization inhibitor (e.g., molecular oxygen (O2)); and, a reducing agent reactive with a free radical species (e.g., a peroxyl radical) formed from the polymerization inhibitor. The reducing agent permits faster printing of objects from the photoresin formulation in a volumetric additive manufacturing process to produce 3D objects of high fidelity.
C09D 11/101 - Encres spécialement adaptées aux procédés d’imprimerie mettant en œuvre la réticulation par énergie ondulatoire ou par radiation de particules, p.ex. réticulation par UV qui suit l’impression
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
B33Y 80/00 - Produits obtenus par fabrication additive
C08L 33/08 - Homopolymères ou copolymères des esters de l'acide acrylique
C09D 4/06 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable en combinaison avec un composé macromoléculaire autre qu'un polymère non saturé des groupes
A method of volumetric additive manufacturing, comprising rotating a vial of photocurable resin; creating patterns of structured light images of an object to be manufactured so that the shape of the light dose distribution matches a desired shape of the object; correcting for diffusion within the vial; projecting the patterns of structured light images via a projector onto the rotating vial of photocurable resin thereby printing the object corrected for diffusion; and removing the printed object from the vial.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
A method and apparatus are set forth for volumetric additive manufacturing (VAM) wherein light rays that are used to determine tomographic projections are modelled using ray tracing, in order to account for projector non-telecentricity and etendue in all three dimensions. The path of rays from each light source (e.g. pixel) are computed as they propagate through the VAM system. Optical effects such as refraction, transmission loss, absorption, etendue, and non-telecentricity are intrinsically accounted for via ray tracing. Using these rays, the required dose to solidify the photosensitive resin is computed.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-β) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
22)); and, a reducing agent reactive with a free radical species (e.g., a peroxyl radical) formed from the polymerization inhibitor. The reducing agent permits faster printing of objects from the photoresin formulation in a volumetric additive manufacturing process to produce 3D objects of high fidelity.
C08L 33/04 - Homopolymères ou copolymères des esters
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
A volumetric additive manufacturing (VAM) process for producing a solid object having a surface layer of a multifunctional material patterned thereon involves: contacting a surface of a solid base object with a liquid composition containing a photo-initiator and a multifunctional material covalently graftable to the surface of the solid base object; and, selectively irradiating the composition at the surface of the solid base object with patterned light, the irradiating being tomographic, to initiate covalent grafting of the multifunctional material to the surface of the solid base object to pattern only a portion of the surface of the solid base object with a layer of the multifunctional material grafted thereon, where the portion of the surface of the solid base object corresponds to the selectively irradiated surface of the solid base object.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
A photoresin formulation for volumetric additive manufacturing contains a photo- curable mixture of: a monomer (e.g., an acrylate-based monomer); a photoinitiator; a polymerization inhibitor (e.g., molecular oxygen (02)); and, a reducing agent reactive with a free radical species (e.g., a peroxyl radical) formed from the polymerization inhibitor. The reducing agent permits faster printing of objects from the photoresin formulation in a volumetric additive manufacturing process to produce 3D objects of high fidelity.
B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
Provided is an adjuvant composition comprising a glycoarchaeol and at least one immunostimulantselected from a Toll-like receptor (TLR) agonist and a saponin. The glycoarchaeol and/orimmunostimulant may be present as a pharmaceutically acceptable salt. The adjuvant compositionmay be comprised together with an antigen in an immunogenic composition, such as a vaccine composition, which may be for use to induce an immune response in a subject. Further provided isuse of the immunogenic composition to induce an immune response in a subject, particularly animmune response that comprises both a cell-mediated response and a humoral response.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/215 - Coronaviridae, p.ex. virus de la bronchite infectieuse aviaire
The present disclosure relates to a single domain antibody that specifically binds to the epitope in the catalytic domain of carbonic anhydrase IX (CA-IX). The single domain antibody has a dissociation constant (KD) of 1×10−7 or lower for a monomeric form of human CA-IX and/or a dimeric form of human CA-IX.
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
A system for forming an object having a three-dimensional structure, the system comprising: a container for providing a photo-curable material to be polymerized; a rotatable stage for supporting the container; a light source for providing light rays having at least one light pattern to be guided into the container via an optical assembly; a processing unit for determining the light source's degree of non-telecentricity, and determining an optimally pre-distorted set of the at least one light pattern based on at least the photo-curable material's refractive index; correcting at least one distortion of the light rays caused by refraction at the container interface and/or correcting at least one distortion of the light rays caused by non-telecentricity; and whereby the correction of the at least one distortion of the light rays is performed without altering the calibration of the optical assembly.
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p.ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p.ex. lasers à balayage ou sources lumineuses focalisées
A method for additive manufacturing of an object having a three-dimensional structure formed from a photo-curable material, the method implemented by a computing device comprising a processor and a computer readable medium having instructions executable by the processor, the method comprising at least the steps of: (a) rotating a vial containing the photo-curable material in a path of a light beam at a predefined rotation speed: (b) calculating patterns associated with a 3D geometry of the object; (c) modulating a focal length of the beam within the photo- curable material while projecting the beam comprising the patterns into the photo- curable material to form the object.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
Described are various embodiments of an ultrasonic structural health monitoring device, system and method. In one embodiment, an ultrasonic structural health monitoring device is described to monitor a structure. The device comprises a bottom electrode disposable on the structure; a piezoelectric medium disposed on the bottom electrode; a top electrode disposed on the piezoelectric medium; an acoustic insulation layer; and a connector to bring electrical excitation for the piezoelectric medium and to collect a generated electric response therefrom representative of structural health.
A method for non-destructive in-situ determination of the R-value of a material at a mean temperature comprises maintaining three or more steady-state temperatures, each for a respective measurement period, measuring temperature and heat flow through the material, calculating R-values at each steady-state temperature and determining the R-value of the material at the mean temperature from the calculated R-values. A system for non-destructive in-situ determination of the R-value of a material at a mean temperature comprises a housing defining a chamber, a temperature control system for heating and cooling the chamber between three or more steady-state temperatures, heat flux transducers, temperature sensors and a computing device from controlling the temperature control system and comprising a data acquisition system for recording measurements from the heat flux transducers and the temperature sensors.
Provided is an enveloped virus-like particle (eVLP) comprising a substantially full-length recombinant SARS-CoV-2 spike (S) protein. The eVLP may further comprise an additional recombinant SARS-CoV-2 S protein having a different sequence, another recombinant viral antigen, or a recombinant non-viral protein. The eVLP is derived from an animal cell, such as a CHO cell, expressing the recombinant SARS-CoV-2 spike protein. Also provided are methods of producing such eVLPs, compositions including such eVLPs, and methods and uses for the induction of an immune response against a SARS-CoV-2 spike protein and/or prevention of COVID-19 or SARS-CoV-2 infection, employing such eVLPs.
Instituto Nacional de Tecnologia Agropecuaria (Argentine)
National Research Council of Canada (Canada)
Inventeur(s)
Mignaqui, Ana Clara
Wigodorovitz, Andres
Durocher, Yves
Abrégé
Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.
C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
C12N 9/64 - Protéinases provenant de tissu animal, p.ex. rennine
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C12N 7/04 - Inactivation ou atténuation; Production de parties élémentaires de virus
18.
MONOLITHIC INTEGRATION OF ENHANCEMENT-MODE AND DEPLETION-MODE GALIUM NITRIDE HIGH ELECTRON MOBILITY TRANSISTORS
A device and method of fabricating a device having depletion-mode and enhancement-mode high-electron-mobility transistors (HEMTs) on a single wafer are disclosed. The method of fabrication involves providing semiconductor layers capable of sustaining a two-dimensional electron sheet to enable electrical current to flow through the HEMT, forming a series of trenches and fins in the semiconductor layers over an active area of the semiconductor layers on which a gate contact terminal is to be set down, the fins of respective HEMTs having different widths resulting in different voltage thresholds for the respective depletion-mode HEMTs.
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 29/10 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices avec des régions semi-conductrices connectées à une électrode ne transportant pas le courant à redresser, amplifier ou commuter, cette électrode faisant partie d'un dispositif à semi-conducteur qui comporte trois électrodes ou plus
A method and apparatus are provided for effecting an RFID-based finger input sensing system using a transmission line connected to at least two RFID tags, by analyzing a plurality of features relating to the number of spikes in the derivatives of the RSS, timing of maximum RSS and the spikes of the RSS derivatives, relative RSS magnitude between the at least two RFID tags, and increase/decrease trend of the RSS, thereby eliminating the need for calibration and training.
G06F 3/046 - Numériseurs, p.ex. pour des écrans ou des pavés tactiles, caractérisés par les moyens de transduction par des moyens électromagnétiques
G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p.ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré
G06F 3/0488 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] utilisant des caractéristiques spécifiques fournies par le périphérique d’entrée, p.ex. des fonctions commandées par la rotation d’une souris à deux capteurs, ou par la nature du périphérique d’entrée, p.ex. des gestes en fonction de la pression exer utilisant un écran tactile ou une tablette numérique, p.ex. entrée de commandes par des tracés gestuels
A method and apparatus for inscribing a high-temperature stable Bragg grating in an optical waveguide, comprising the steps of: providing the optical waveguide; providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 micrometers (μm); providing cylindrical focusing optics; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intensive to cause permanent (Type II) change in the index of refraction within multiple Bragg grating planes in the core of the optical waveguide resulting from at least one micropore.
G01D 5/353 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c. à d. utilisant de la lumière infrarouge, visible ou ultraviolette avec atténuation ou obturation complète ou partielle des rayons lumineux les rayons lumineux étant détectés par des cellules photo-électriques en modifiant les caractéristiques de transmission d'une fibre optique
G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
The use of an unctuous sealing material (high viscosity liquid bordering on, or having, solid behavior at low shear forces) for sealing open pore, highly crushable suction cups allows for increased surface conformation for fast secure vacuum gripping, and maintenance of the pressure differential with lower energy in view of the seal. Furthermore, fast grasping is demonstrated if the unctuous sealing material protrudes from the lip.
There is provided a biosensor for detecting water contaminants. The biosensor has a microbial fuel cell compartment, having (i) at least one opening to allow water into and out of the microbial fuel cell compartment, (ii) an anode comprising electroactive microorganisms, and (iii) a cathode. The anode is electrically and physically separated from the cathode. The anode is anaerobic and comprises electroactive microorganisms. The cathode is aerobic. The biosensor has a storage compartment housing a biodegradable carbon source to supply the biodegradable carbon source to the electroactive microorganisms; an electric impedance load; an electric switch forming an intermittent connection between the microbial fuel cell compartment and the electric impedance load; an electric sensor; and a control system coupled to the electric switch and the electric sensor, receiving a measurement from the electric sensor, and outputting an indication signaling the presence or absence of the water contaminants based on the measurement.
The present invention provides an efficient quantum memory for storing a quantum state of light, such as a photon, for a temporary period of time in a fibre-integrated optical cavity and then recall the quantum state of light and quantum information at a later time with a high probability of success. The present invention uses a nonlinear optical switching mechanism to modify at least one property of the quantum light, or cavity, to trap the quantum light in the optical cavity. Subsequent application of the nonlinear optical switching mechanism switches at least one property of the stored quantum light, or cavity, to release the quantum light from the optical cavity. The present invention also provides quasi-deterministic single-photon generation by temporal multiplexing of a photon pair source integrated within the cavity.
G11C 13/04 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments optiques
G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
G02F 1/313 - Dispositifs de déflexion numérique dans une structure de guide d'ondes optique
A device and method of fabricating a device having a plurality of depletion-mode high-electron-mobility transistors (HEMTs) on a single wafer are disclosed. The method of fabrication involves providing semiconductor layers capable of sustaining a two-dimensional electron sheet to enable electrical current to flow through the HEMT, forming a series of trenches and fins in the semiconductor layers over an active area of the semiconductor layers on which a gate contact terminal is to be set down, the fins of respective HEMTs having different widths resulting in different voltage thresholds for the respective depletion-mode HEMTs.
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
H01L 29/423 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative ne transportant pas le courant à redresser, à amplifier ou à commuter
25.
NEUROMORPHIC CAMERA IN A LASER WARNING SYSTEMS (LWS)
HIS MAJESTY THE KING IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCE (Canada)
Inventeur(s)
Orth, Antony
Stewart, Terrence
Picard, Michel
Drouin, Marc-Antoine
Théberge, Francis
Abrégé
A target located method and apparatus for the detection of lasers directed at the target using neuromorphic cameras which improve the detection by use of defocus.
G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
H04N 25/47 - Capteurs d'images avec sortie d'adresse de pixel; Capteurs d'images commandés par événement; Sélection des pixels à lire en fonction des données d'image
The present disclosure provides a non-destructive technique for the measurement of bearing element speed and/or pass-frequency (roller speed and/or pass- frequency for roller bearings or ball speed and/or pass-frequency for ball bearings) that can be compared with a rotational rate of the rotary element to evaluate skidding. The technique employs a high temperature optical emitter and detector pair, which may be adjacent in a reflective setup, or at opposite sides of the bearing in a pitch-catch setup. The emitter has an opening angle of 45-120 to enable the sensor to operate in an oil droplet laden environment. In either configuration, the sensors have been successfully demonstrated at speeds beyond 20,000 rpm and oil supply temperatures up to 82 C, and have been demonstrated on roller bearings featuring metallic and polymer-based cages. The sensors are also not sensitive to bearing material and can achieve results with metal as well as hybrid bearings (e.g. ceramic rollers).
An example semiconductor device includes: a first layer comprising a first semiconductor material; a second layer comprising a second semiconductor material; and an interface region disposed between the first layer and the second layer and corresponding to an expected depletion region of an interface between the first semiconductor material and the second semiconductor material, the interface region comprising a gradation from the first semiconductor material to the second semiconductor material; and wherein the interface region is configured to reduce Shockley-Read-Hall recombination in the semiconductor device.
H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
H01L 31/0304 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
Cellulose particles treated with a bio-based surfactant can be compounded into a polymer composite having improved mechanical properties, such as tensile strength and/or tensile modulus. Treatment can be integrated into an industrial scale continuous cellulose particle production process, and the process provides one or more of reduced environmental impact, reduced energy consumption, reduced chemical consumption, reduced water consumption, reduced processing/operational cost, reduced capital investment, increased output, improved fiber dispersion in the polymer matrix and improved thermal degradation properties of the composite.
There is provided a method for fabricating a corrugated buried heterostructure laser, including patterning a dielectric layer coating a substrate having a <0-11> direction to obtain a hollow corrugated structure. The hollow corrugated structure includes a central portion and regularly spaced-apart tabs laterally extending from the central portion and aligned with the <0-11> direction. The method also includes, in a single metal organic chemical vapour deposition run, forming an active region in the hollow corrugated structure to obtain the corrugated buried heterostructure laser. The single run combines selective area growth, p-dopant diffusion and etching techniques. There is also provided a corrugated buried heterostructure laser including a substrate having a <0-11> direction, a corrugated structure defined in the substrate and including a central portion and regularly spaced-apart tabs laterally extending from the central portion and aligned with the <0-11> direction, and an active region grown in the corrugated structure.
H01S 5/12 - Structure ou forme du résonateur optique le résonateur ayant une structure périodique, p.ex. dans des lasers à rétroaction répartie [lasers DFB]
30.
METHOD FOR LYOPHILIZING LIVE VACCINE STRAINS OF FRANCISELLA TULARENSIS
There are provided compositions and methods for lyophilization and/or storage of live vaccine strains of Francisella tularensis. More specifically, there are provided lyophilization media and uses thereof for the preparation and long-term storage of Francisella tularensis vaccines.
An electrical machine, which may be a motor and/or a generator has a rotor mounted to rotate about an axis. A plurality of magnetic poles are spaced circumferentially around the rotor in the bore. The rotor comprises a shell shaped to provide a toroidal bore centered on the axis. A slit extends circumferentially around the rotor. The slit penetrates through the shell into the bore. The electrical machine also includes a stator that is supported in the bore by one or more supports extending through the slit of the rotor. The stator carries plural windings that are spaced apart around the bore.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles located in at least a portion of the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
The present disclosure relates to methods and systems for realization of a reference pressure as well as calibration of devices under test. The techniques leverage the measurement of buoyancy artifacts under vacuum and pressure conditions, and the use of gas law equations and related variables to obtain low uncertainty reference values for pressure among others. The techniques can include measuring an absolute mass difference of buoyancy artifacts under vacuum; measuring effective masses of the buoyancy artifacts under a gas pressure condition, and determining an effective mass difference between the buoyancy artifacts; and determining a low-uncertainty pressure based on the absolute mass difference, effective mass difference, Boltzmann constant, volume difference, molecular weight of the gas at pressure, and temperature of the measurements.
A heterostructure laser is provided comprising an epitaxially grown substrate of first dopant type, an active region and layer of second dopant type, a narrow mesa having less than 20% open area and a side wall slope of less than 85 degrees, wherein said narrow mesa is etched through the active region and layer of second dopant type using in-situ MOCVD, a plurality of current blocking layers, an overclad layer and a contact layer of second dopant type, and an isolation mesa incorporating the narrow mesa, wherein the isolation mesa is etched through the active region, layer of second dopant type and plurality of current blocking layers and wherein the plurality of current blocking layers is grown without exposure to oxygen.
G01P 3/38 - Dispositifs caractérisés par l'emploi de moyens optiques, p.ex. en utilisant la lumière infrarouge, visible ou ultraviolette en utilisant des moyens photographiques
G01V 8/00 - Prospection ou détection par des moyens optiques
36.
SYNCHRONOUS RECTIFICATION TO IMPROVE EFFICIENCY OF ELECTRICITY CONVERSION FOR HARVESTING ENERGY FROM LOW VOLTAGE SOURCES
A DC-DC converter for converting a low voltage DC input to a higher voltage DC output, the DC-DC converter comprising: an oscillator comprising a first relatively voltage sensitive and relatively low power transistor and a second relatively voltage insensitive and relatively high power transistor, the oscillator producing an AC signal from the low voltage DC input; a first transformer for converting the AC signal produced by the oscillator to a higher voltage AC signal; an autonomous, synchronous voltage-doubling rectification circuit for converting the higher voltage AC signal to the higher voltage DC output, wherein the autonomous, synchronous voltage-doubling rectification circuit comprises a second transformer, a first shunt switch and a second shunt switch; and wherein current through the second transformer controls the synchronous rectification.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
37.
Systems and methods for the production of diphtheria toxin polypeptides
An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
C07K 14/34 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Corynebacterium (G)
C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
38.
PHASE-SHIFTED FIBER BRAGG GRATING SENSOR AND METHOD FOR PRODUCING SAME
T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
39.
MESA AVALANCHE PHOTODIODE WITH SIDEWALL PASSIVATION
A mesa-type avalanche photodiode comprising a first mesa of n-type material, a second mesa having an active region, and a third mesa of p-type material, wherein the second mesa includes a p-type sidewall formed by Zn diffusion for suppressing sidewall leakage current.
H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche
H01L 31/0304 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
H01L 31/02 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails
40.
LAMINATED ARMOR MATERIALS FOR ENHANCED BALLISTIC PROTECTION
The present disclosure relates to laminated armor materials for enhanced ballistic protection. In particular, the present disclosure relates to laminated armor materials comprising first and second armor materials and a laminated adhesive layer comprising nanomaterial fillers.
F41H 5/04 - Structure des plaques composées de plus d'une couche
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 3/14 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche discontinue, c. à d. soit continue et percée de trous, soit réellement constituée d'éléments individuels caractérisés par une couche de surface formée d'éléments individuels
B32B 27/20 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers utilisant des charges, des pigments, des agents thixotropiques
B32B 27/34 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyamides
B32B 9/00 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes
B32B 9/04 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes comprenant une telle substance comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
41.
3D-PRINTABLE PIEZOELECTRIC CERAMIC COMPOSITIONS WITH CARBON NANOMATERIALS
An extrudable ceramic composition comprises piezoelectric ceramic particles and carbon nanomaterial particles suspended in a carrier medium. A piezoelectric ceramic material is produced by curing the composition. The carbon nanomaterials are used as additives to extrudable ceramic compositions (e.g., piezoelectric compositions such as PZT/polymer composites, PZT/sol-gel composites, PZT emulsion pastes and the like). The addition of carbon nanomaterials imparts both beneficial rheological properties (shear thinning) and improved piezoelectric performance to the ceramic material.
C04B 35/491 - Produits céramiques mis en forme, caractérisés par leur composition; Compositions céramiques; Traitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxydes de zirconium ou d'hafnium ou de zirconates ou d'hafnates contenant également de l'oxyde de titane ou des titanates à base de zirconates de plomb et de titanates de plomb
B28B 1/14 - Fabrication d'objets façonnés à partir du matériau par simple coulée, le matériau n'étant ni alimenté sous pression, ni réellement compacté
B28B 1/54 - Fabrication d'objets façonnés à partir du matériau spécialement adaptée à la fabrication d'objets à partir de matériaux fondus, p.ex. laitier
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
C04B 35/63 - Préparation ou traitement des poudres individuellement ou par fournées utilisant des additifs spécialement adaptés à la formation des produits
C04B 35/653 - Procédés comportant une étape de fusion
An extrudable composition includes: an aqueous phase comprising acidic water and piezoelectric ceramic particles suspended in the water; and, an organic phase having an organic solvent, a curable polymer precursor or both an organic solvent and a curable polymer precursor. The composition is 3-D printable to form a self-supporting structure and may be infiltrated with an organic polymer material or cured so that the curable polymer precursor forms an organic polymer material thereby forming a piezoelectric composite having piezoelectric ceramic particles in a co-continuous phase.
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
C04B 35/491 - Produits céramiques mis en forme, caractérisés par leur composition; Compositions céramiques; Traitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxydes de zirconium ou d'hafnium ou de zirconates ou d'hafnates contenant également de l'oxyde de titane ou des titanates à base de zirconates de plomb et de titanates de plomb
C08K 3/01 - Emploi de substances inorganiques en tant qu'adjuvants caractérisées par leur fonction
C08L 101/00 - Compositions contenant des composés macromoléculaires non spécifiés
H10N 30/084 - Mise en forme ou usinage de corps piézo-électriques ou électrostrictifs par moulage ou extrusion
The present document describes a pharmaceutical composition comprising a) a lipid nanoparticle operable to encapsulate a therapeutic agent, comprising a core and an external surface, said therapeutic agent being encapsulated within said core; said lipid nanoparticle having a size of said lipid nanoparticle of from about 30 to about 80 nm, or a pegylated lipid comprising a distearoyl-rac-glycerol (DSG) – PEG and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- (DSPE) – PEG - DBCO; or a combination of: a size of from about 30 to about 80 nm and a pegylated lipid comprising a DSG-PEG and DSPE-PEG-DBCO; and b) an antibody or antigen-binding fragment thereof operable to transmigrate the blood-brain barrier (BBB), wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDR1, CDR2 and CDR3), operably linked to said external surface of said lipid nanoparticle.
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 47/14 - Esters d’acides carboxyliques, p.ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/24 - Composés organiques, p.ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p.ex. cyclométhicone ou phospholipides
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation utilisant la micro-encapsulation, p.ex. utilisant des vésicules liposomiques
44.
ANTIBODIES WITH ENGINEERED O-GLYCOSYLATION SEQUONS FOR SITE-SPECIFIC CONJUGATION
The present document describes antibodies or antigen-binding fragments that bind specifically to a target antigen, wherein the antibodies or antigen-binding fragments comprise complementarity determining regions (CDR1, CDR2 and CDR3) and an added O-glycosylation sequon glycosylated with an O-glycan having the general formula (I) : wherein R1is an initial N-acetylgalactosamine (GalNAc); n = 1, or 2; R2are each independently absent, galactose (Gal), GalNAc, N-Acetylglucosamine (GlcNAc), or a sialic acid; R3 are each independently absent, Gal or a sialic acid; and R4 are each independently absent or a sialic acid. Also described are compounds comprising the antibodies or antigen-binding fragments comprising a functional moiety operably linked to said O-glycan, compositions comprising the same, and methods of preparing such compounds.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
C07K 9/00 - Peptides ayant jusqu'à 20 amino-acides, contenant des radicaux saccharide et comportant une séquence entièrement déterminée; Leurs dérivés
The present invention concerns new strains of cyanogenic bacteria, and more particularly alkali-tolerant Pseudomonas bacteria, that are useful to gold mining activities. These bacteria are useful to leach gold from any source including ores, concentrates or waste material. They have the ability to effectively produce cyanide at alkaline pH.
C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
C22B 3/18 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés à l'aide de micro-organismes ou d'enzymes, p.ex. de bactéries ou d'algues
C22B 11/08 - Obtention des métaux nobles par cyanuration
46.
PIEZOCERAMIC PASTES WITH HIGH CERAMIC CONTENT AND METHOD FOR PRINTING SAME
The present disclosure is directed towards a formulation for piezoelectric materials. The formulation may be printed including 2D or 3D printing. The formulation contains ceramic particles, a sol-gel, a high boiling point solvent and a binder.
The present invention concerns new strains of cyanogenic bacteria, and more particularly alkali-tolerant Pseudomonas bacteria, that are useful to gold mining activities. These bacteria are useful to leach gold from any source including ores and concentrates. They have the ability to effectively produce cyanide at alkaline pH.
C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
C22B 3/18 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés à l'aide de micro-organismes ou d'enzymes, p.ex. de bactéries ou d'algues
C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide
C07K 14/21 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
C07K 14/34 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Corynebacterium (G)
C07K 14/195 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
49.
BIODEGRADABLE ELECTROCHEMICAL DEVICE AND METHODS THEREOF
An electrochemical device is disclosed, which may include an anode, a cathode, and a molded electrolyte composition disposed between the anode and the cathode. Implementations of the electrochemical device may include where the cathode and/or the anode are disposed in a stacked geometry. The electrolyte composition may include a gel polymer electrolyte, which can include a hydrogel of a copolymer and a salt dispersed in the hydrogel of a copolymer. The electrolyte composition may alternatively include a crosslinker or a photoinitiator. A method of producing an electrolyte layer of an electrochemical device is also disclosed, including preparing a substrate having an electrode for an electrochemical device, preparing a gasket to form a cavity on the substrate for the electrolyte layer, and depositing an electrolyte composition onto the substrate
H01M 10/0565 - Matériaux polymères, p.ex. du type gel ou du type solide
H01M 10/0585 - Structure ou fabrication d'accumulateurs ayant uniquement des éléments de structure plats, c. à d. des électrodes positives plates, des électrodes négatives plates et des séparateurs plats
50.
FUSION PROTEIN COMPRISING A BLOOD-BRAIN BARRIER (BBB)-CROSSING SINGLE DOMAIN ANTIBODY FC5, AN IMMUNOGLOBULIN FC FRAGMENT AND A BETA-AMYLOID BINDING POLYPEPTIDE (ABP)
A brain-penetrating composition of amyloid-β binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-β targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
51.
BIODEGRADABLE ELECTROCHEMICAL DEVICE AND METHODS THEREOF
An electrochemical device is disclosed, which may include an anode, a cathode, and a molded electrolyte composition disposed between the anode and the cathode. Implementations of the electrochemical device may include where the cathode and/or the anode are disposed in a stacked geomety. The electrolyte composition may include a gel polymer electrolyte, which can include a hydrogel of a copolymer and a salt dispersed in the hydrogel of a copolymer. The electrolyte composition may alternatively include a crosslinker or a photoinitiator. A method of producing an electrolyte layer of an electrochemical device is also disclosed, including preparing a substrate having an electrode for an electrochemical device, preparing a gasket to form a cavity on the substrate for the electrolyte layer, and depositing an electrolyte composition onto the substrate
H01M 6/18 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments primaires; Leur fabrication Éléments avec électrolytes non aqueux avec électrolyte solide
A computer-implemented method comprising the steps of: with an imaging device, acquiring a plurality of images of structures of a fabricated device; preprocessing the plurality of images; creating at least one image dataset from the preprocessed plurality of images; generating a predictor model; training the predictor model with the at least one image dataset to identify structural features of the fabricated device with a propensity for fabrication anomalies.
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
B82Y 40/00 - Fabrication ou traitement des nanostructures
G01N 23/2251 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p.ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux en utilisant des microsondes électroniques ou ioniques en utilisant des faisceaux d’électrons incidents, p.ex. la microscopie électronique à balayage [SEM]
G01N 37/00 - RECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES - Détails non couverts par les autres groupes de la présente sous-classe
G06F 30/398 - Vérification ou optimisation de la conception, p.ex. par vérification des règles de conception [DRC], vérification de correspondance entre géométrie et schéma [LVS] ou par les méthodes à éléments finis [MEF]
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
An interface device for performing off-chip coupling in optical waveguides includes an optical waveguide core for propagating light of a particular wavelength or a plurality of wavelengths and an array of radiative elements configured to change the propagation direction of the light. The optical waveguide core is configured to control the effective refractive index of the propagation mode of the light. The device can thus serve as an optical antenna for coupling between a waveguide mode and a free-space propagating beam or a plurality of free-space propagating beams in an arrayed configuration.
A computer-implemented method for detecting attribute value pairs from corpus data using a computer comprising a processor and a computer readable medium comprising instructions executable by the processor to at least: receive the corpus data comprising at least one pair; detect a layout template of the at least one pair; measure the merit of the layout template by determining at least one of (a) relative magnitudes of content probabilities based on a probability of the contents of an attribute cell and a probability of a corresponding value cell, (b) the validity of a name-value pair, or (c) the pointwise mutual information of a frequency matrix M corresponding to a sparse vector capturing context information of a word; and output detected attribute value pairs.
A composite material suitable for use in sensing and catalysis applications with conjugated polymers non-covalently bound to the carbon nanotubes. The conjugated polymers have alternating aromatic (Ar) units and bipyridine (BPy) units. Metal nanoparticles having a size that is between about 0.3 nm and about 5 nm are bound to the conjugated polymers at respective BPy units, thereby anchoring the metal nanoparticles to the carbon nanotubes. Thus, a metal salt solution was added into the polymer/carbon nanotube solution to form a metal-BPy complex, which is in situ photo reduced to metal nanoparticles. Therefore, the formed nanoparticles are tightly anchored to the nanotube and can be self-regenerated by room light to offer the material a high performance and durability.
C01B 32/174 - Dérivatisation; Solubilisation dans les solvants; Dispersion dans les solvants
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
B82Y 40/00 - Fabrication ou traitement des nanostructures
G01N 27/30 - Composants de cellules électrolytiques Électrodes, p.ex. électrodes pour tests; Demi-cellules
56.
MULTI-CHANNEL ANALOG-SIGNAL-INPUT TO DIGITAL-SIGNAL-OUTPUT DOWN-CONVERSION AND DIGITAL-SIGNAL-INPUT TO ANALOG-SIGNAL-OUTPUT UP-CONVERSION PHOTONICS MICROWAVE SYSTEMS BASED ON QUANTUM DOT MULTI-WAVELENGTH LASERS
Methods and systems for down-conversion of high frequency signals in millimeter-wave (mm-wave) communications and for up-conversion of high frequency signals in millimeter-wave (mm-wave) communications. A quantum dot multi-wavelength laser (QD MWL) source generates an optical signal comprising of a plurality of optical channels and allows flexible selection of the optical channels which can be used to generate and process RF signals in higher frequency bands of mm-wave spectrum including K-band, Ka-band V-band, W-band encompassing all 3GPP NR FR2 bands and even THz range depending on the channel spacing.
A computer-implemented method comprising the steps of: with an imaging device, acquiring a plurality of images of structures of a fabricated device; preprocessing the plurality of images; creating at least one image dataset from the preprocessed plurality of images; generating at least one of a predictor model and a corrector model; training the predictor model with the at least one image dataset to identify structural features of the fabricated device with a propensity for fabrication deviations, wherein the corrector model is useful for completing tasks comprising of at least: receiving a desired layout as input and generating a layout output, and automatically correcting the device design to minimize the impact of fabrication deviations on its operation.
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
G01R 31/28 - Test de circuits électroniques, p.ex. à l'aide d'un traceur de signaux
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
58.
NARROW LINEWIDTH LASER WITH FLAT FREQUENCY MODULATION RESPONSE
A laser comprising a narrow linewidth, comprising: a grating along a laser cavity; a laser waveguide having a plurality of waveguide sections corresponding to a plurality of grating sections, each of the plurality of waveguide sections having a ridge/mesa width for detuning the grating in each of the plurality of grating sections; and a plurality of contact electrodes contacting each of the plurality of waveguide sections, the plurality of contact electrodes for applying a different current to each of the plurality of waveguide sections to enable active feedback noise suppression.
H01S 5/22 - Structure ou forme du corps semi-conducteur pour guider l'onde optique ayant une structure à nervures ou à bandes
H01S 5/10 - Structure ou forme du résonateur optique
H01S 5/0625 - Dispositions pour commander les paramètres de sortie du laser, p.ex. en agissant sur le milieu actif en faisant varier le potentiel des électrodes dans des lasers à plusieurs sections
59.
ANTI-CD22 SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC CONSTRUCTS
Herein are provided anti-CD22 single domain antibodies (sdAb) prepared by immunizing a llama with the extracellular domain of the predominant human CD22 isoform. By constructing a library of the heavy chain repertoire generated, VHH antibodies specific to the immunogen were isolated. The 27 example antibodies initially produced comprise CDR1, CDR2, and CDR3 sequences corresponding, respectively to SEQNOs: 1-3, 4-6, 7-9, 10-12, 13-15, 16- 18, 19-21, 22-24, 25-27, 28-30, 31-33, 34-36, 37-39, 40-42, 43-45, 46-48, 49-51, 52-54, 55- 57, 58-60, 61-63, 64-66, 67-69, 70-72, 73-75, 75-78, and 79-81; and related sequences. Also provided are multivalent antibodies comprising any one of the sdAbs, including bispecific T-cell engagers, bispecific killer cell engagers (BiKEs), and trispecific killer cell engagers (TriKEs). Also described are chimeric antigen receptors (CARs) for CAR-T therapy comprising any one of the aforementioned sdAbs. Uses of these molecules in the treatment of cancer are also described.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A composite material suitable for use in sensing and catalysis applications with conjugated polymers non-covalently bound to the carbon nanotubes. The conjugated polymers have alternating aromatic (Ar) units and bipyridine (BPy) units. Metal nanoparticles having a size that is between about 0.3 nm and about 5 nm are bound to the conjugated polymers at respective BPy units, thereby anchoring the metal nanoparticles to the carbon nanotubes. Thus, a metal salt solution was added into the polymer/carbon nanotube solution to fonn a metal- BPy complex, which is in situ photo reduced to metal nanoparticles. Therefore, the fomied nanoparticles are tightly anchored to the nanotube and can be self-regenerated by room light to offer the material a high performance and durability.
C08L 79/04 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale; Polyhydrazides; Polyamide-acides ou précurseurs similaires de polyimides
C01B 32/174 - Dérivatisation; Solubilisation dans les solvants; Dispersion dans les solvants
B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
C08K 7/24 - Particules expansibles, poreuses ou creuses inorganiques
C08L 65/00 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principale; Compositions contenant des dérivés de tels polymères
A biodegradable solid aqueous electrolyte composition, an electrochemical device incorporating the electrolyte composition, and methods for the same are provided. The electrolyte composition may include a rubber-like hydrogel including a copolymer and a salt. The copolymer may include at least two polycaprolactone chains coupled with a polymeric center block. The polymeric center block may include polyvinyl alcohol. The hydrogel may be biodegradable. The electrochemical device may include an anode, a cathode, and the electrolyte composition disposed between the anode and the cathode.
C08L 29/04 - Alcool polyvinylique; Homopolymères ou copolymères d'esters partiellement hydrolysés d'alcools non saturés avec des acides carboxyliques saturés
C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p.ex. lactones
H01M 6/18 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments primaires; Leur fabrication Éléments avec électrolytes non aqueux avec électrolyte solide
An example system for co-liquefying feedstock and yellow grease includes: a feedstock container to contain a feedstock; a yellow grease container to contain a yellow grease; a hydrothermal liquefaction system configured to receive feedstock from the feedstock container and to receive yellow grease from the yellow grease container; the feedstock received by the hydrothermal liquefaction system and the yellow grease received by the hydrothermal liquefaction system to become a mixture; a controller connected to the feedstock container and the yellow grease container, the controller configured to control the amount of the feedstock supplied from the feedstock container to the hydrothermal liquefaction system, the controller further configured to control the amount of the yellow grease supplied from the yellow grease container to the hydrothermal liquefaction system to be between 10% to 50% of the mixture; and a collector configured to receive a bio-crude from the hydrothermal liquefaction system.
C10G 1/00 - Production de mélanges liquides d'hydrocarbures à partir de schiste bitumineux, de sable pétrolifère ou de matières carbonées solides non fusibles ou similaires, p.ex. bois, charbon
63.
BLOOD-BRAIN BARRIER TRANSMIGRATING COMPOUNDS AND USES THEREOF
A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
An antenna device for performing off-chip light coupling comprising an array of radiating elements whose thickness is larger than λ/2, the radiating elements being chosen such that the length of the array is smaller than 10λ, where λ is the wavelength of light in the material chosen for the radiating elements. An advantage of this method is that, unlike in conventional waveguide grating antenna, by reducing the number of the radiating elements in the array, the dependence of the off-chip emission angle on the wavelength of light can be greatly reduced. Another advantage is that by using thick radiating elements the antenna efficiency can be greatly enhanced, thereby compensating for the reduced efficiency occurring as a consequence of using only a small number of radiating elements in the array.
The present application relates to methods of preparing a coated substrate and coated substrates which can be optionally prepared from such methods. The methods comprise depositing on the substrate a single abrasion resistant layer by magnetron sputtering or depositing on the substrate a dual layer comprising a first abrasion resistant layer deposited by magnetron sputtering and a second abrasion resistant layer deposited by plasma-enhanced chemical vapor deposition.
C23C 28/04 - Revêtements uniquement de matériaux inorganiques non métalliques
C23C 14/35 - Pulvérisation cathodique par application d'un champ magnétique, p.ex. pulvérisation au moyen d'un magnétron
C23C 16/50 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement au moyen de décharges électriques
Volumetric Additive Manufacturing allows for the rapid printing of objects by transmitting images into a reservoir holding resin, using wavelengths of light assocaited with a photocuring characteristic of the resin. Feedback based control can be enabled through the use of optical scattering tomography based imaging of the object during the printing process. Through capturing a set of images representing the scattering of a non-curing light, an isosurface representing the object during printing can be generated. The differences between the isosurface and the expected shape of the object can be used as an input into a control process or they can be displayed to an operator so that printing can be terminated when the printing of the object is complete.
B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
G01B 11/25 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes en projetant un motif, p.ex. des franges de moiré, sur l'objet
67.
COMPOSITIONS, DEVICES AND METHODS FOR TREATING CNS DISORDERS
Described herein are BBB-transporting fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating various CNS diseases and conditions, e.g., any mucopolysaccharidosis type with CNS manifestations.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Described herein are ARSB fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating MPS-6.
A method of fabricating a conductive yarn comprising a plurality of filaments, the method comprising the steps of: (a) applying a reducing agent solution to the treated surface; and (b) applying a metal ion solution to the treated at least one of the lurality of filaments. The method comprising a further step of treating the surface of the at least one of the plurality of filaments with a hydrophilic agent before performing steps (a) and (b).
D06M 11/83 - Traitement des fibres, fils, filés, tissus ou des articles fibreux faits de ces matières, avec des substances inorganiques ou leurs complexes; Un tel traitement combiné avec un traitement mécanique, p.ex. mercerisage avec des composés libérant des métaux, p.ex. des métaux-carbonyles; Réduction de composés métalliques sur des textiles
H01B 1/22 - Matériau conducteur dispersé dans un matériau organique non conducteur le matériau conducteur comportant des métaux ou des alliages
H05K 1/03 - Emploi de matériaux pour réaliser le substrat
H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
A method of monitoring both liner wear and charge impact in an industrial mill uses a sensor mounted on an elongated element deployed through a shell into a liner of the mill. The elongated element wears at a same rate as the liner under conditions within the shell. Liner wear is related to a reduction in length of the elongated element as measured by travel time of an ultrasound wave, while location and strength of charge impact is related to change in amplitude of vibrations caused by the charge impact. Liner wear measurement can be improved by using shear ultrasound waves instead of conventional longitudinal ultrasound waves. A mill monitoring apparatus has a means for acquiring ultrasonic waves and audible sound waves using the same digitizer; a means for determining the angular position of the monitoring apparatus; and a means for supplying electric power to the apparatus.
B02C 17/18 - Désagrégation au tonneau, c. à d. par des appareils constitués par une cuve où les produits à désagréger sont chargés, avec ou sans éléments particuliers de désagrégation tels que billes ou boulets - Parties constitutives
A composition comprising a mixture of two or more stereoisomers of a synthetic charged isoprenoid glycolipid of Formula (I), or a pharmaceutically acceptable salt thereof, in which n is 0 or 1, R and R' are independently hydrogen or hydroxyl, each Y is independently hydrogen or a sulfate group, and wherein at least one Y is a sulfate group, and less than 25% of the synthetic charged isoprenoid glycolipid molecules in the mixture comprise an archaeol moiety of the configuration (R)-2,3-bis(((3R,7R,11R)-3,7,11,15-tetramethylhexadecyl)oxy) propan-1-ol. Further provided are archaeosomes and immunogenic compositions comprising the composition,use of the composition as an adjuvant or immunostimulant, and processes for synthesizing the composition.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
A61K 31/08 - Ethers ou acétals acycliques, p.ex. paraformaldéhyde
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07C 41/14 - Préparation d'éthers par remplacement des substituants sur l'oxygène de la fonction éther par d'autres substituants, p.ex. par transéthérification
C07C 43/13 - Ethers saturés contenant des groupes hydroxyle ou O-métal
C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide
A coated electrode assembly (CEA) comprising: i) a gas diffusion layer (GDE); and ii) a coating. The GDE comprises a gas diffusion layer (GDL) and a catalyst layer. The catalyst layer is disposed between the coating and the GDL. The catalyst layer comprises a hydrophobic polymer and/or an ionomeric polymer and the coating comprises a hydrophobic polymer and/or an ionomeric polymer. A method for making a CEA is provided. The CEA may have improved performance and stability compared to a membrane electrode assembly (MEA).
C25B 11/032 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées Électrodes poreuses Électrodes à diffusion de gaz
C25B 11/056 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par le matériau Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau du substrat ou du support constitué d'une matière textile ou non tissée
C25B 11/053 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par le matériau Électrodes comportant des électro-catalyseurs sur un substrat ou un support Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques caractérisées par des revêtements électro-catalytiques multicouches
C25B 9/17 - Cellules comprenant des électrodes fixes de dimensions stables; Assemblages de leurs éléments de structure
73.
A COMPOSITION FOR DISINFECTION AND A METHOD OF PREPARING A DISINFECTANT
2 2222 is doped to red-shift its absorption spectrum. The present specification further provides a method of preparing a disinfectant which contains a titanium dioxide nanoparticle and a dopant.
A61L 2/238 - Métaux ou alliages, p.ex. métaux oligodynamiques
A61L 2/232 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contact; Accessoires à cet effet utilisant des substances chimiques des substances solides, p.ex. des granules, des poudres, des blocs, des comprimés en couches ou revêtues
74.
THERMALLY CURABLE PIEZOELECTRIC COMPOSITES AND USE THEREOF IN ADDITIVE MANUFACTURING
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles and a polymer material comprising at least one thermoplastic polymer and at least one thermally curable polymer precursor. At a sufficient temperature, the at least one thermally curable polymer precursor may undergo a reaction, optionally also undergoing a reaction with the piezoelectric particles, and form an at least partially cured printed part. The piezoelectric particles may be mixed with the polymer material and remain substantially non-agglomerated when combined with the polymer material. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste, which may be utilized in forming printed part by extrusion, layer-by-layer deposition, and thermal curing.
C09D 4/06 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable en combinaison avec un composé macromoléculaire autre qu'un polymère non saturé des groupes
A deformable minor system comprising: a deformable mirror surface; a plurality of actuators coupled to the mirror surface to deform the minor surface; and a detector coupled to the actuators to detect, for each actuator, an output signal from a driver of the actuator; and a controller coupled to each of the plurality of actuators, wherein the controller is configured, for each actuator, to: add a test signal to an input signal to form a modified input signal; send the modified input signal to the actuator; receive an indication of the output signal from the driver; determine when a test signal portion of the output signal satisfies a threshold condition; and in response to the test signal portion satisfying the threshold condition, control a subset of adjacent actuators to execute a shutdown sequence.
G01M 11/00 - Test des appareils optiques; Test des structures ou des ouvrages par des méthodes optiques, non prévu ailleurs
G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
76.
ULTRAFAST TEMPORAL FILTERING FOR QUANTUM COMMUNICATIONS
A quantum communication method comprising: at a sender, preparing photons encoded in a single spatial, spectral, and temporal (SST) mode to form a quantum signal; and introducing the quantum signal into a quantum channel; at a receiver, a detector and filtering system optically processing the quantum signal and rejecting background noise photons in the quantum channel, and performing active temporal filtering by switching the polarization of the quantum signal without substantially adding noise; and wherein the active temporal filtering minimizes saturation of the detector.
Disclosed are devices with dynamic optical properties suitable for use as security or authentication devices, for example for documents or items of importance or value, in order to help prevent counterfeit of the same. Such devices, at least in selected embodiments, enable observation of dynamic changes or moving entities within the device by collective or enhanced imaging of the dynamic changes or moveable entities, the motion or position of which may otherwise be difficult to observe, or indiscernible to, the naked eye.
Disclosed are devices with dynamic optical properties suitable for use as security or authentication devices, for example for documents or items of importance or value, in order to help prevent counterfeit of the same. Such devices, at least in selected embodiments, enable observation of dynamic changes or moving entities within the device by collective imaging of the dynamic changes or moveable entities, the motion or position of which may otherwise be difficult to observe, or indiscernible to, the naked eye.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions that are extrudable and comprise a plurality of piezoelectric particles and a plurality of carbon nanomaterials dispersed in at least a portion of a polymer material. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further containing at least one polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
C08L 53/02 - Compositions contenant des copolymères séquencés possédant au moins une séquence d'un polymère obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carbone; Compositions contenant des dérivés de tels polymères contenant des monomères vinylaromatiques et des diènes conjugués
C09D 167/04 - Polyesters dérivés des acides hydroxycarboxyliques, p.ex. lactones
H10N 30/85 - Matériaux actifs piézo-électriques ou électrostrictifs
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
The present invention is directed to SARS-CoV-2 spike protein specific antibodies and antibody fragments, compositions comprising the antibodies or antibody fragments, and uses thereof. The anti-spike protein antibodies and antibody fragments may be specific for SARS-CoV-2 including current and emerging virus variants. The invention also includes methods of treating a SARS-CoV-2 infection, methods of capturing SARS-CoV-2 spike proteins, and methods of detecting SARS-CoV-2 spike proteins using the antibodies or antibody fragments.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
81.
DIAGNOSTIC LIPID BIOMARKERS FOR COVID-19 AND METHODS FOR USE THEREOF
The disclosure relates to methods for diagnosing, detecting or screening for COVID-19 in a subject. The method comprises measuring the concentration of at least two sphingolipids in a blood sample. The sphingolipids are selected from Cer(d18:1/16:0), Cer(d18:1/26:0), 1-O-nervonoyl-Cer(d18:1/18:2), HexCer(d18:1/22:0), Cer(d18:1/18:0) and PE-Cer(d18:1/24:0). The method further comprises determining a ratio of the concentration of the at least two sphingolipids and comparing the ratio with a reference value, wherein a differential between the ratio and the reference value is indicative that the subject has or likely has COVID-19. Also provided is a kit for use with the method disclosed herein.
A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (µm); providing cylindrical focusing optics corrected for spherical aberration; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.
A method for detecting and identifying a remote gas, the method comprising the steps of: receiving a light wave associated with the remote gas; coupling the light wave into a single mode fibre; transmitting the light wave via the single mode fibre into a filter comprising a fibre-based tunable cavity; modulating the cavity length of the filter transmission window to cause a detected modulated signal that is proportional to the spectral feature; and processing the signal using a lock-in amplifier capable of low-pass filtering and out-of-frequency noise rejection.
A forming tool with forced thermal fluid-based spatio-temporal temperature control of a surface of the tool has a subsurface manifold underlying at least a part of a forming surface of the tool and a number P of at least 6 ports, each port fluid coupled respectively to the manifold via respective channels, where the ports exit the tool at disparate points, with each pair of ports in fluid communication via the manifold. This structure allows manifold path diversity for varying thermal fluid supply and drainage. The manifold may be reinforced.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles dispersed in at least a portion of a polymer matrix comprising first polymer material and a sacrificial material, the sacrificial material being removable from the polymer matrix to define a plurality of pores in the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The sacrificial material may comprise a second polymer material. The compositions may define a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer and introducing porosity therein.
B29C 48/05 - Moulage par extrusion, c. à d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désirée; Appareils à cet effet caractérisées par la forme à l’extrusion de la matière extrudée filamentaire, p.ex. fils
Methods and systems for determining a change in condition of a rock bolt. Some methods may comprise, at a first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a first time of flight for each of the shear and longitudinal waves, at a second point in time after the first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a second time of flight for each of the shear and longitudinal waves, and using the relative changes of the first and second time of flights, determining the change in condition of the rock bolt section.
E21D 21/02 - Boulons d'ancrage pour la protection du toit, de la sole ou du revêtement des puits ayant des moyens pour indiquer la tension
G01N 29/07 - Analyse de solides en mesurant la vitesse de propagation ou le temps de propagation des ondes acoustiques
G01M 5/00 - Examen de l'élasticité des structures ou ouvrages, p.ex. fléchissement de ponts ou d'ailes d'avions
G01N 29/32 - Dispositions pour supprimer des influences indésirables, p.ex. des variations de température ou de pression
G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques
G01N 3/00 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique
G01N 3/02 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique - Parties constitutives
87.
MULTI-INPUT, MULTI-OUTPUT MANIFOLD FOR THERMOCONTROLLED SURFACES
A forming tool with forced thermal fluid-based spatio-temporal temperature control of a surface of the tool has a subsurface manifold underlying at least a part of a forming surface of the tool and a number P of at least 6 ports, each port fluid coupled respectively to the manifold via respective channels, where the ports exit the tool at disparate points, with each pair of ports in fluid communication via the manifold. This structure allows manifold path diversity for varying thermal fluid supply and drainage. The manifold may be reinforced.
A semiconductor high electron mobility transistor (HEMT)-based device configured to detect ionizing radiation, wherein the device comprises: a substrate; a nucleation layer formed on the substrate; a gallium nitride (GaN) buffer layer arranged on the nucleation layer; a GaN channel layer arranged on the GaN buffer layer; an aluminum nitride (A1N) spacer layer arranged on the GaN channel layer; a barrier layer arranged on the A1N spacer layer; a GaN cap layer arranged on the barrier layer; an electrically insulating silicon nitride (SiNx) passivation layer arranged on the GaN cap layer; a source, a drain and a gate, wherein the source and the drain are formed on the GaN cap layer; wherein charge carriers generated by the radiation in the underlying GaN layers are collected in the GaN channel layer and multiplied by impact ionization by a high electric field at the gate edge facing the drain contact.
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
89.
Use of Human Resistin as a Trimerization Partner for Expression of Trimeric Proteins
Provided is a recombinant polypeptide comprising a resistin trimerization domain and a polypeptide of interest. Further provided is an expression vector encoding the recombinant polypeptide and a method of expressing the recombinant polypeptide. The polypeptide of interest may be a trimeric viral surface antigen or a portion thereof, such as the ectodomain of the SARS-CoV-2 spike protein. Further provided are compositions, such as immunogenic compositions and vaccines, comprising the recombinant polypeptide.
C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
A computer-implemented method for communications network maintenance, the method comprising the steps of: acquiring raw data associated with the communications network a plurality of datasets; preprocessing the raw data by converting the raw data into a predefined data format to form a plurality of datasets and correcting any inconsistencies in the plurality of datasets; training a neural network with the plurality of datasets to detect at least one of an anomalous event and a network anomaly event, and localizing the communications network anomaly event to infer at least one root cause for the communications network anomaly event; and creating and executing a self-maintenance scheme to mitigate against effects of the at least one of the anomalous event and the communications network anomaly event.
H04L 41/16 - Dispositions pour la maintenance, l’administration ou la gestion des réseaux de commutation de données, p.ex. des réseaux de commutation de paquets en utilisant l'apprentissage automatique ou l'intelligence artificielle
H04L 41/0631 - Gestion des fautes, des événements, des alarmes ou des notifications en utilisant l’analyse de la corrélation entre les notifications, les alarmes ou les événements en fonction de critères de décision, p.ex. la hiérarchie ou l’analyse temporelle ou arborescente
H04B 1/74 - TRANSMISSION - Détails des systèmes de transmission non caractérisés par le milieu utilisé pour la transmission pour augmenter la fiabilité, p.ex. en utilisant des canaux ou des appareils supplémentaires ou de réserve
A modulation method comprising steps of: a) generating a first signal having a first train of short pulses having a first frequency, and a second signal having a second train of short pulses having a second frequency, wherein each of the signals are associated with a negative or positive sign; b) maintaining a narrow frequency difference between the frequencies; c) imposing chirped modulation on each of the signals to achieve a desired spectral resolution, such that each signal is associated with a chirp having a first sign and a second sign; and d) switching between the signs for each signal over a frequency range, and detecting for each frequency of said frequency range, a spectral response resulting from a transfer of said modulation between the signals wherein the chirp sign of each of the signals is different, thereby obtaining hyperspectral data of said spectral response over said frequency range.
G01J 3/44 - Spectrométrie Raman; Spectrométrie par diffusion
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
92.
WATER SOLUBLE FORMULATIONS CONTAINING CANNABINOIDS
The present disclosure relates to water-soluble formulations containing cannabinoids. In particular, the formulations comprise at least one isolated cannabinoid, cannabinoid oil or cannabinoid resin, and a solubilizing agent of Formula (I), where the group X is a residue of a hydrophobic moiety selected from sterols, tocopherols, and derivatives thereof, and the group Y is a residue of a hydrophilic moiety selected from polyalcohols, polyethers, and derivatives thereof. In preferred embodiments, the cannabinoid comprises cannabidiol (CBD) or Δ9-tetrahydrocannabinol (THC) and the hydrophobic moiety is polyoxyethanyl-α-tocopheryl sebacate (TPS). In embodiments, the formulations comprise a carrier oil, such as a medium length triglyceride (MCT), and are dispersed in water in the form of micelles.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p.ex. cannabinols, méthanthéline
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer material comprising at least one thermoplastic polymer, and a plurality of piezoelectric covalently bonded to the at least one thermoplastic polymer and dispersed in at least a portion of the polymer material. The compositions are extrudable and may be pre-formed into a form factor suitable for extrusion. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
94.
PIEZOELECTRIC COMPOSITES FEATURING NONCOVALENT INTERACTIONS AND USE THEREOF IN ADDITIVE MANUFACTURING
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles non-covalently interacting with at least a portion of a polymer material via π-π bonding, hydrogen bonding, electrostatic interactions stronger than van der Waals interactions, or any combination thereof. The piezoelectric particles may be dispersed in the polymer material and remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further including a polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles substantially localized in one of the first polymer material or the second polymer material. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles and a polymer material comprising at least one thermoplastic polymer and at least one photocurable polymer precursor. The at least one photocurable polymer precursor may undergo a reaction in the presence of electromagnetic radiation, optionally undergoing a reaction with the piezoelectric particles, in the course of forming the printed part. The piezoelectric particles may be mixed with the polymer material and remain substantially non-agglomerated when combined with the polymer material. The compositions may define a form factor such as a composite filament, a composite pellet, or an extrudable composite paste, which may be utilized in forming printed parts by extrusion and layer-by-layer deposition, followed by curing.
C09D 4/06 - Compositions de revêtement, p.ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable en combinaison avec un composé macromoléculaire autre qu'un polymère non saturé des groupes
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p.ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
09 - Appareils et instruments scientifiques et électriques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Fiber optic couplers; fiber optic couplings; fibre optic light and image conduits; laser diode modules; laser diodes; light diodes; optical amplifiers; optical multiplexers; optical semi-conductor amplifiers; optical semiconductor amplifiers; optical transceivers; optical switches; optical transceivers; optical transmitters; optical waveguides; photomasks; photometers; photoresistors; photosensors; quantum dot light emitting diodes [QLED]; semi-conductor chips; semiconductor wafers; semi-conductors; semiconductor chips; semiconductor diodes; semiconductor integrated circuits; semiconductor transistors; semiconductor wafers; semiconductors; super luminescent laser diodes; transistors; wafers for integrated circuits; Gallium (GaN) electronics; Indium Phosphide (InP) Photonic Integrated Circuits (PICs); Indium Phosphide (InP), Gallium Arsenide (GaAs), and Gallium Antimonide (GaSb) wafers for lasers diodes (1) Analysis and evaluation of product design; analysis and evaluation of product development; consultancy and research in the field of quantum engineering; design of integrated circuits; design of design of optical and micro optical components; electrical engineering; optical laboratories; physics research; quantum computing; research and design in the field of electrical engineering; research and design in the field of physics; research in the area of semiconductor processing technology; research in the field of electrical engineering; Surface Analysis and Materials Characterization; Epitaxial growth of compound semiconductors materials using Metalorganic Chemical Vapour Deposition (MOCVD), Chemical Beam Epitaxy (CBE) and Molecular Beam Epitaxy (MBE)
98.
PIEZOELECTRIC COMPOSITES CONTAINING A SACRIFICIAL MATERIAL AND USE THEREOF IN ADDITIVE MANUFACTURING
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles located in a polymer matrix comprising a first polymer material and a sacrificial material that are immiscible with each other. The sacrificial material, which may comprise a second polymer material, may be removable from the first polymer material under specified conditions. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The polymer matrix may be treated to remove the sacrificial material to introduce a plurality of pores. The compositions may have a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
B29C 64/40 - Structures de support des objets en 3D pendant la fabrication, lesdites structures devant être sacrifiées après réalisation de la fabrication
99.
RAISED FLUIDIC CHANNELS AND METHODS OF MANUFACTURE
A ridge fluidic device comprising: a substrate and a fluidic component comprising at least one fluidic channel, wherein the at least one fluidic channel is adapted to conduct a fluid and retain the fluid within the at least one fluidic channel; wherein the at least one fluidic channel comprises porous material having a hydrophilic surface; and wherein the at least one fluidic channel is formed on the substrate via a deposition process.
A rail assembly for use with a bogie wheel includes two rail segments having mating end segments abutting against each other, and joined by a connecting bolt that traverse the mating end segments. A bogie for use with a rail includes a support frame, a chassis movably attached to the support frame, and an elastomeric bearing disposed between and in bearing engagement with the support frame and the chassis, to limit movement of the chassis relative to the support frame. A bogie wheel includes a central hub adapted for direct mounting to a bogie chassis, a tread, and a bearing assembly permitting rotation of the tread relative to the hub. An inflatable seal assembly for sealing between a first member and a second member includes an inflatable bladder, a membrane attached to the first member, and a tension spring attached to the membrane to bias the membrane against the bladder.
E01B 25/00 - Voies pour types particuliers de chemins de fer
B61F 5/00 - SUSPENSIONS DES VÉHICULES FERROVIAIRES, p.ex. CHÂSSIS, BOGIES OU AMÉNAGEMENTS DES ESSIEUX DES ROUES; VÉHICULES FERROVIAIRES UTILISABLES SUR VOIES D'ÉCARTEMENT DIFFÉRENT; PRÉVENTION DES DÉRAILLEMENTS DE VÉHICULES FERROVIAIRES; COUVRE-ROUES, DÉBLAYEURS D'OBSTACLES OU DISPOSITIFS SIMILAIRES POUR VÉHICULES FERROVIAIRES - Détails de structure des bogies; Liaisons entre bogies et châssis du véhicule; Aménagements ou dispositifs pour ajuster ou permettre l'auto-ajustement des essieux des roues ou des bogies dans les courbes
E04H 5/00 - Bâtiments ou groupes de bâtiments à des fins industrielles ou agricoles
F16J 15/48 - Joints d'étanchéité par bague de garniture dilatée ou comprimée dans son logement par pression d'un fluide, p.ex. garnitures gonflables la pression provenant de celle existant dans l'organe à isoler
G02B 23/16 - Logements; Couvercles; Montures; Supports, p.ex. avec contrepoids
