Abstract

The invention provides a method for quantifying the number of target entities that were successfully encapsulated into a microfluidic compartment such as a microfluidic droplet. The invention is predicated upon a continuous quantifiable detectable signal corresponding to the quantity of entities encapsulated in a microfluidic compartment. The present invention is useful in the context of high throughput microfluidic screening approaches which require thorough signal normalization in order to reliably improve signal to noise ratio and to reliably identify screening hits.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Disclosed herein are peptide-grafted compounds that irreversibly deactivate bacteriophages or influenza virus depending on the peptide and remain safe for bacteria and mammalian cells. The active compounds comprise a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages or for influenza. Further, said compounds can be used directly inside the environment of the bioreactor, but they are also a safe additive to stocks of antibiotics and expression inducers (such as isopropyl ß-D-1-thiogalactopyranoside, i.e., IPTG), that cannot be autoclaved and are a common source of phage infections. The anti-influenza compound may be used as a drug to be given in therapeutic or prophylactic mode to fight influenza infection.

IPC Classes  ?

• A01N 37/46 - N-acyl derivatives
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 31/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermen
• A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof

Abstract

The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at least one conducting material for forming at least one elongated electrical channel of the microelectrode; providing an insulator material on the conducting material to define at least one active site or area of the microelectrode, providing a protection material or layer onto the first side of the silicon substrate or layer; etching the silicon material of a second side of the silicon substrate to form at least one elongated projection extending away from the silicon substrate, the elongated projection comprising the conducting material, and expose an elongated surface of the conducting material of the elongated projection; removing the protection material or layer from the first side of the silicon substrate; and providing a further insulator material on the exposed elongated surface of the conducting material to isolate the elongated electrical channel of the at least one microelectrode, and providing the further insulator material on the etched at least one silicon substrate.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/372 - Arrangements in connection with the implantation of stimulators
• A61N 1/375 - Constructional arrangements, e.g. casings

Abstract

A modular multiple frequency coils inductive link system to wirelessly provide power for at least a medical implant at an output of a receiving coil, whereby the receiving coil is configured to be implanted in an organism. The modular multiple frequency coils inductive link comprises a transmitter coil configured to input power from a power supply and induce a first magnetic field at a resonating carrier frequency. The modular multiple frequency coils inductive link further comprises a shifting resonator comprising at least an active integrated circuit, a first coil configured to receive the first induced magnetic field from the transmitter coil by induction at the resonating carrier frequency and convert it to an electrical current, and a second coil configured to transmit the electrical current to the receiving coil by inducing a second magnetic field at a determined frequency different from the resonating carrier frequency, the active integrated circuit connected with both the first coil and the second coil and being configured to receive the power induced at the resonating carrier frequency though the first coil and to use it to drive remaining power reduced due to a power dissipation of the active integrated circuit at the determined frequency though the second coil. The receiving coil is configured to receive the power induced by the second coil at the determined frequency and make it available at the output of the receiving coil.

IPC Classes  ?

• H01F 38/00 - Adaptations of transformers or inductances for specific applications or functions
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• A61N 1/372 - Arrangements in connection with the implantation of stimulators

Abstract

The invention relates to an Imaging sensor device in a stacked arrangement comprising: - a pixel array tier comprising a plurality of pixel segments each having a plurality of pixels for photon detection each providing a digital pixel output; - a processing tier comprising a number of processing cores each associated with one of the plurality of pixel segments to receive the pixel outputs of the pixels of the respective pixel segment, wherein the processing cores are each in bidirectional communication with one or more neighboring processing cores, wherein the processing cores are each configured to receive pixel outputs of the pixels of the associated pixel segments and to distribute processing of pixel outputs between the processing core and the at least one of the neighboring processing cores as neighboring processing cores.

IPC Classes  ?

• H04N 25/78 - Readout circuits for addressed sensors, e.g. output amplifiers or A/D converters
• H04N 25/79 - Arrangements of circuitry being divided between different or multiple substrates, chips or circuit boards, e.g. stacked image sensors
• H04N 25/773 - Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters comprising photon counting circuits, e.g. single photon detection [SPD] or single photon avalanche diodes [SPAD]

Abstract

A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/374 - Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves

Abstract

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross-sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.

IPC Classes  ?

• A61B 8/06 - Measuring blood flow
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

A micromachined mechanism for a sensing tool includes a support, a probe pivotally mounted with respect to the support, and a beam connected to the support and the probe. The probe is configured to apply a load (Ftool) on a body and to be subjected to a counter-reaction contact force exerted by the body in reaction to the load. The beam is configured to shift from an undeformed position to a deformed position when the contact force of the body is greater than a predetermined threshold force (Fcrit) for which the beam buckles.

IPC Classes  ?

• A61B 5/12 - Audiometering
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection.

IPC Classes  ?

• A61P 31/14 - Antivirals for RNA viruses
• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

Abstract

The present invention concerns a method of manoeuvring a vertical take-off and landing, unmanned aerial drone (100) comprising at least an aerodynamic surface (101), wherein, during a flight of the drone, the aerodynamic surface generates lift and/or drag and an aerodynamic surface area is dynamically varied to compensate for adverse wind currents and/or to use said wind currents and/or to use an effective airspeed velocity as an assistance in manoeuvring the drone flight, said aerodynamic surface area variations allowing to reduce an energy consumption of the drone.

IPC Classes  ?

• B64C 3/54 - Varying in area
• B64U 10/20 - Vertical take-off and landing [VTOL] aircraft
• B64U 30/12 - Variable or detachable wings, e.g. wings with adjustable sweep

Abstract

The present disclosure concerns a membrane-less electrolyzer comprising a first electrode and a second electrode, a first fluidic channel configured to receive an electrolyte, a second fluidic channel configured to receive the electrolyte from the first fluidic channel, a third fluidic channel configured to receive the electrolyte from the first fluidic channel. The first fluidic channel being in fluidic communication with the second and third fluidic channels. The first fluidic channel is connected to the second and third fluidic channels via a plurality of inclined fluidic canals extending from the first fluidic channel to each of the second and third fluidic channels.

IPC Classes  ?

• C25B 11/03 - Electrodes; Manufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte
• C25B 15/08 - Supplying or removing reactants or electrolytes; Regeneration of electrolytes

Abstract

A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents

Abstract

A method for aggregating digital signatures comprises the following steps carried out by a signature aggregator: receiving first data packages from signers, each first data package comprising a signer identifier, a payload, and a payload signature; verifying the payload signatures to determine whether or not the payloads are correctly signed; bundling correctly signed payloads into a batch; obtaining a batch digest, and proofs of inclusion of the payloads in the batch; sending second data packages comprising the batch digest and a respective proof of inclusion to the signers, the respective proof of inclusion proving that the payload of the respective signer is included in the batch; receiving third data packages from the signers, each third data package comprising the signer identifier, and a respective batch digest signature; verifying the batch digest signatures to determine whether or not the batch digests are correctly signed; aggregating correctly signed batch digest signatures to obtain an aggregated batch digest signature; and including the aggregated batch digest signature in the batch. The payload and batch digest signatures may be obtained by using different secret keys of the respective signer.

IPC Classes  ?

• G06F 21/64 - Protecting data integrity, e.g. using checksums, certificates or signatures
• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
• H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system

Abstract

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
• F04B 43/04 - Pumps having electric drive
• F04B 43/09 - Pumps having electric drive
• F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
• F04B 43/14 - Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members

Abstract

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or within at least a portion of said substrate; ii) a stretchable interconnect comprising an intrinsically elastic substrate, said substrate comprising at least one well or groove comprising at least one compliant conductive element therein, said at least one well or groove being configured to accommodate said at least one conductive track of said interconnection board; and iii) at least one bolus of an electrically conductive paste located within said at least one well or groove, configured to electrically connect said at least one compliant conductive element with said at least one conductive track.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• H05K 1/03 - Use of materials for the substrate
• H05K 1/09 - Use of materials for the metallic pattern
• H05K 3/10 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
• H05K 3/38 - Improvement of the adhesion between the insulating substrate and the metal

Abstract

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so called old mRNA and such differences compared to control cell assays. The invention is applicable for screening in particular candidate ligand molecules such as antibodies for an effect on target cells, and thereby provides new strategies for the identification of therapeutically active compounds.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6804 - Nucleic acid analysis using immunogens

Abstract

244.

IPC Classes  ?

• C10L 3/06 - Natural gas; Synthetic natural gas obtained by processes not covered by , or
• C10L 3/08 - Production of synthetic natural gas
• C10L 3/10 - Working-up natural gas or synthetic natural gas
• F17D 1/04 - Pipe-line systems for gases or vapours for distribution of gas

Abstract

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property and configured to cover a molar tooth, and an internally exposed intermediate region defined by a third material property and configured to be located between the occlusional cushioning region and the impact protective region, wherein said first, second and third material properties are different. A corresponding method of fabricating a mouthguard is also described.

IPC Classes  ?

• A63B 71/08 - Body-protectors for players or sportsmen
• B33Y 10/00 - Processes of additive manufacturing

Abstract

A fin field-effect transistor (FinFET) based semiconductor memory array having a plurality of memory cells, each memory cell including a write transistor having a write wordline gate over a first fin connected to a write wordline gate contact, a write bitline contact in connection with the first fin, and a storage node contact in connection with the first fin, and a read transistor having a storage node gate over a second fin, the storage node gate connected to a storage node gate contact, the storage node gate contact connected to the storage node contact, a read wordline contact in connection with the second fin, and a read bitline contact in connection with the second fin, wherein the write wordline gate and the storage node gate are arranged in series to each other along an extension axis that coincides with an longitudinal axis of the write wordline gate and a longitudinal axis of the storage node gate.

IPC Classes  ?

• G11C 11/419 - Read-write [R-W] circuits
• G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only
• H01L 27/11 - Static random access memory structures
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 27/088 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate

Abstract

A water permeation sensor suitable for monitoring and quantitatively assessing ultra-low permeability of thin film encapsulations engineered for bioelectronic microdevices, its fabrication as well as device comprising the same are disclosed herein.

IPC Classes  ?

• A61B 5/263 - Bioelectric electrodes therefor characterised by the electrode materials
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/266 - Bioelectric electrodes therefor characterised by the electrode materials containing electrolytes, conductive gels or pastes

Abstract

[0054] Methods are provided for estimating key reliably and accurately predicting cardiac output using a limited set of non-invasively monitored physiologic inputs, and a calibrated one- dimensional arterial tree model, a database of synthetic data generated from such a model, and an artificial intelligence module. Systems for estimating CO based on non-invasively measured physiologic inputs also are provided that may be implemented without the need for extensive real-time computing resources.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthaldynamometers
• A61B 5/029 - Measuring blood output from the heart, e.g. minute volume

Abstract

A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., wherein each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from said method are also disclosed.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B29C 64/245 - Platforms or substrates
• A61L 27/56 - Porous or cellular materials
• B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
• B29C 35/16 - Cooling
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Goods & Services

Databases (electronic), in relation to the following fields: Apiculture; Intelligent systems for controlling honey production in beehives; Software for planning, integrating and optimising smart hive applications; Intelligent gateways for real-time data analysis, in relation to the following fields: Apiculture and Bee behaviour; Intelligent gateways for data pre-processing, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Intelligent portals for software-defined data storage related to beekeeping and bee behaviour, health and honey production; Software for monitoring, analysing, controlling and managing bees in hives; Intelligent software for the production related to the production of honey from bees; Computers for controlling control devices for bees and hives; Computer software for biometric systems for bee identification and authentication; Downloadable computer software for remote monitoring and analysis, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Computer software for collecting bee positioning data; Application software for robot bees; Smart hive application software, smart hive automation software; Software for automating the production process in intelligent hives; Software for controlling the movement of bees; Environmental control software; Process controlling software, in relation to the following fields: Apiculture; Software for controlling processes in intelligent hives; Environmental monitoring software; Software for optical bee recognition; Laboratory robot bees; Training robot bees; Scientific research and laboratory apparatus, educational apparatus and simulators; Apparatus and instruments for scientific research purposes and Laboratory apparatus and Apparatus for laboratories, Teaching apparatus and Teaching apparatus and Simulators for training courses, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Measuring, detecting, monitoring and controlling devices; Devices for measuring, detecting, monitoring and controlling bees; Apparatus for biometric identification of bees; Weather information apparatus; Teaching and instructional apparatus, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Biochips; Temperature sensing apparatus for scientific use, in relation to the following fields: Apiculture; Instructional and teaching apparatus and instruments, in relation to the following fields: Apiculture; Electronic instructional and teaching apparatus and instruments, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Teaching apparatus, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Instrumentation simulators, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Sensors, detectors and devices for monitoring bees in smart hives; Data loggers and recorders, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Testing and quality control devices; Controllers and regulators relating to beekeeping and bee behaviour, health and honey production; Measuring devices, in relation to the following fields: Apiculture, The behaviour, health status and honey production of bees; Air analysis apparatus; Monitoring instruments, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Automated bee detection systems; Computerised bee behaviour and health analysers; Computer hardware for monitoring the behaviour of winners; Tools for analysing bee behaviour, health and honey production; Beehive automation systems; Digital bee locator apparatus; Digital indicators, in relation to the following fields: Apiculture and Bee behaviour, health, location and honey production; Apparatus and instruments for physics; Image analyzers, in relation to the following fields: Apiculture and Bee behaviour, health, location and honey production; Beehive automation devices; Devices and tools for checking (supervision, control) of beehives; Video surveillance apparatus for bees [electronic]; Bee global positioning apparatus; Video monitoring apparatus for bees [satellite]; Bee flight control apparatus; Navigation, guidance, tracking, targeting and map making devices, in relation to the following fields: Bees and robot bees; Infrared bee locators and robot bees; Gyrocompasses; Electronic tags for bees and robot bees; Electronic navigation systems, in relation to the following goods: Robot bees; Navigating apparatus (Electronic -), for use in relation to the following goods: Robot bees; Electronic tracking apparatus and instruments, in relation to the following fields: Bees and robot bees; Sensors for determining position, in relation to the following fields: Bees and robot bees; Optical position sensors, for use in the following fields: Bees and robot bees; Optical apparatus for locating bees and bee robots; Tracking devices, for use in the following fields: Bees and robot bees; Robot bees. Beehives; Artificial honeycombs for beehives; Sections of wood for beehives; Intelligent (smart) beehives; Automated beehives. Data mining, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Professional consultancy relating to technology, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Science and technology services, in relation to the following fields: beekeeping, Breeding and reproduction of bees; IT services, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services, in relation to the following fields: Design of machines for beekeeping, breeding and reproduction of bees; Engineering services relating to information technology, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to automatic data processing, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to the design of communications systems, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering design and consultancy, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Consultancy services relating to product engineering, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Computer-aided engineering design services relating to beekeeping, reproduction and breeding; Technology assessments relating to beekeeping, breeding and reproduction provided by engineers; Testing, authentication and quality control, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Analysis and evaluation of product development, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to robotics, in relation to the following fields: beekeeping, Breeding and reproduction of bees; inspecting, in relation to the following fields: Bee breeding; Investigations, in relation to the following fields: Bee breeding; Tests, in relation to the following fields: Bee breeding; Development, in relation to the following goods: Computer hardware relating to beekeeping, breeding and reproduction of bees; Development, Programming and Implementation, in relation to the following goods: Computer software relating to beekeeping, breeding and reproduction of bees; Research relating to the development of computer hardware relating to beekeeping, breeding and reproduction of bees; Consultancy and information, in relation to the following fields: Design and development of computer hardware relating to beekeeping, breeding and reproduction of bees; Design of computer hardware for the beekeeping, breeding and reproduction of bees industry; Design of computer hardware and software.

Abstract

ESP particle collector (1) for collecting particles in a particle containing gas stream, comprising an inlet section (4), a collector section (6), and an electrode arrangement (8), the inlet section comprising a flow tube (10) defining a gas flow channel (12) therein bounded by a guide wall (24) extending between an entry end (14) and a collector end (16) that serves as an inlet to the collector section (6), the entry end comprising an inlet (28) for the particle gas stream and a sheath flow inlet portion (26) for generating a sheath flow around the particle gas stream, the collector section comprising a housing (18) coupled to the flow tube, and a collector plate (20) mounted therein having a particle collection surface (23). The ESP particle collector is configured to allow optical analysis of the collector plate particle collection surface to measure particles collected thereon. The electrode arrangement comprises at least a base electrode (8a) positioned below the collection surface and a counter-base electrode (8b) positioned at a separation distance L2 above the collection surface such that an electrical field is generated between the electrodes configured to precipitate said particles on the collection surface, wherein the electric field is in a range of 0.1 kV per mm to 1.5 kV per mm, with an absolute voltage on any said electrode that is less than 10 kV, and wherein a ratio ratio I of a radius L1 of said inlet at the collector end divided by said separation distance L2 is in a range of 0.8 to 1.2.

IPC Classes  ?

• B03C 3/06 - Plant or installations having external electricity supply dry type characterised by presence of stationary tube electrodes
• B03C 3/49 - Collecting-electrodes tubular
• B03C 3/38 - Particle charging or ionising stations, e.g. using electric discharge, radioactive radiation or flames
• B03C 3/36 - Controlling flow of gases or vapour

Abstract

Disclosed is a flexure pivot based system being one of: a force sensor, a force limiting device arranged to exert a predetermined threshold force, a torque limiting device arranged to exert a predetermined threshold torque, a programmable mechanical memory, or an accelerometer, the flexure pivot based system including a substantially rigid frame supporting a lever by a suspension mechanism including: a first flexure extending from the frame to a junction with the lever; a second flexure extending from the frame to the junction at a first non-zero angle to the first flexure in a neutral position of the suspension mechanism; and a third flexure extending from the junction to a preloading system at a second non-zero angle to the first flexure and/or the second flexure in the neutral position, the preloading system applying a force in a direction substantially coaxial with the third flexure.

IPC Classes  ?

• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes

Abstract

Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treating aneurysms in challenging anatomy such as the thoracic aorta. The compliant vascular grafts preferably have an outer frame layer and an inner graft layer with a plurality of pleats to permit expansion.

IPC Classes  ?

• A61F 2/06 - Blood vessels
• A61F 2/07 - Stent-grafts

Abstract

A scintillation device including a silicon plate having a rectangular shape and having a first side and a second side opposite the first side, wherein the first side includes a plurality of first channels arranged to be in parallel with each other extending in a first direction, wherein walls in the silicon plate that form the first channels are coated with an optically reflective or dielectric layer, and wherein the first channels are filled with a scintillation resin in a solid state forming a first waveguide.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/203 - Measuring radiation intensity with scintillation detectors the detector being made of plastics

Abstract

A method for manufacturing a scintillation detector structure including the steps of forming a plurality of first structures into a surface of a substrate to form a patterned substrate, filling the plurality of first structures and covering the surface of the substrate with a polymeric material, hardening the polymeric material and first removing the hardened polymeric material from the substrate to obtain a polymeric mold with a patterned surface having a plurality of second structures, performing a surface cleaning treatment and a silanization of the patterned surface of the polymeric mold, filling the plurality of second structures and covering the patterned surface of the polymeric mold with a moldable scintillation material, polymerizing the scintillation material while exerting a pressure on the scintillation material, and second removing the polymerized scintillation material from the plurality of second structures of the polymeric mold to obtain scintillation detector active structures.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
• C08L 83/04 - Polysiloxanes
• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• B29C 33/40 - Plastics, e.g. foam or rubber

Abstract

The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation Δ ⁢ E = f E ⁢ hc λ ⁢ N ⁢ or ⁢ Δ ⁢ E = f E ⁢ E p N .

IPC Classes  ?

• H01J 37/22 - Optical or photographic arrangements associated with the tube
• H01J 37/244 - Detectors; Associated components or circuits therefor
• H01J 37/28 - Electron or ion microscopes; Electron- or ion-diffraction tubes with scanning beams
• H01J 37/20 - Means for supporting or positioning the object or the material; Means for adjusting diaphragms or lenses associated with the support

Abstract

Herein described are diaryl ether compounds having the structure (I) as well as a method for their manufacture from lignin.

IPC Classes  ?

• C07C 47/575 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing ether groups, groups, groups, or groups
• C07C 69/92 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Abstract

The invention provides an in vitro method for the cell-free quantification of virus neutralizing activity, such as the SARS-CoV-2 neutralizing activity, of biological samples and kit for carrying out the method. The invention also provides a method of screening biological samples or collections of molecules to identify neutralizing antibodies or antiviral drugs.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Electrolyser including a reactor (2) comprising a housing (4), fluidic channels (6a, 6b, 6c) within the housing, and electrodes (16a, 16c) comprising an anode (16a) and a cathode (16c). The fluidic channels include an inter-electrode channel (6b) arranged between the anode (16a) and cathode (16c) and connected to an anode channel inlet (8a) for injection of an electrolyte into the inter-electrode channel (6b), a cathode channel (6c) separated from the inter-electrode channel (6b) by a porous cathode side wall (14c) comprising a plurality of canals (20), and an anode channel (6a) separated from the inter-electrode channel (6b) by a porous anode side wall (14a) comprising a plurality of canals (20). Each canal has a tapered shape such that an inlet surface area (Si) of the canal is greater than an outlet surface area (So) of the canal, the inlet surface area being on a side of the porous walls bounding the inter-electrode channel (6b).

IPC Classes  ?

• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte
• C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms two or more diaphragms
• C25B 11/03 - Electrodes; Manufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 13/02 - Diaphragms; Spacing elements characterised by shape or form

Abstract

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions or methods using IL-4, a fragment or variant thereof, fused to a moiety, to increase the efficacy of an anti-cancer immunotherapy or an autoimmune therapy.

IPC Classes  ?

• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• C07K 14/54 - Interleukins (IL)

Abstract

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, the step of predicting at least one target buried interface site comprises generating at least one surface fingerprint associated with a protein interaction based on at least one protein interface, wherein the at least one surface fingerprint preferably embeds geometric and/or chemical features of molecular surfaces, identifying at least one binding seed that displays required features to engage the target site, and performing a binding seed transplantation to protein scaffolds to confer stability and additional contacts on the designed interface.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural data; Docking or binding prediction
• G16B 20/30 - Detection of binding sites or motifs
• G16B 40/20 - Supervised data analysis

Abstract

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by between-assembly links, each node assembly itself comprising a network of nodes interconnected by a plurality of within-assembly links, wherein each of the between-assembly links and the within-assembly links have an associated weight, each weight embodying a strength of connection between the nodes joined by the associated link, the nodes within each assembly being more likely to be connected to other nodes within that assembly than to be connected to nodes within others of the node assemblies.

IPC Classes  ?

• G06N 3/045 - Combinations of networks
• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
• G06N 3/08 - Learning methods

Abstract

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition in a subject by administering an engineered progenitor cell or an engineered cell differentiated from an engineered progenitor cell of the present disclosure.

IPC Classes  ?

• C12N 5/0784 - Dendritic cells; Progenitors thereof

Abstract

Nanopore-based scanning system including a probe structure comprising a nanopore; suction means configured to draw an end of a (bio)molecule inside the nanopore and inside the probe structure, single or multiple times; and displacement means configured to mechanically displace the probe structure and the nanopore relative to the one (bio)molecule along a direction following a direction of extension of the (bio)molecule while the (bio)molecule is located inside the nanopore and inside the probe structure, or configured to mechanically displace at least one support holding the (bio)molecule relative to the nanopore along a direction following a direction of extension of the (bio)molecule while holding the at least one support and while the (bio)molecule is located inside the nanopore.

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes
• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6869 - Methods for sequencing
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01Q 60/44 - SICM [Scanning Ion-Conductance Microscopy] or apparatus therefor, e.g. SICM probes

Abstract

The present invention concerns an electrolysis system for high temperature electrolysis including a plurality of flow-based electrolysis units configured to receive an electrolyte solution and to perform electrolysis to provide a first output gas and a second output gas, the plurality of flow-based electrolysis units being membrane-less electrolysis units; at least one heating mechanism or means for heating the electrolyte solution to undergo electrolysis; a first gas separator and a second gas separator configured to remove the first output gas and the second output gas from the electrolyte solution; and an encasement or a cell enclosing the plurality of flow-based electrolysis units, the encasement or the cell being configured to support a pressure of the electrolyte solution permitting to increase a boiling point of the electrolyte solution to a temperature between 96°C and 350°C.

IPC Classes  ?

• C25B 1/042 - Hydrogen or oxygen by electrolysis of water by electrolysis of steam
• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte
• C25B 9/60 - Constructional parts of cells
• C25B 9/67 - Heating or cooling means
• C25B 9/70 - Assemblies comprising two or more cells
• C25B 11/031 - Porous electrodes
• C25B 11/046 - Alloys
• C25B 15/025 - Measuring, analysing or testing during electrolytic production of electrolyte parameters
• C25B 15/08 - Supplying or removing reactants or electrolytes; Regeneration of electrolytes

Abstract

Systems and methods for data storage and readout using hybrid nucleic acid-polymeric molecules are herein disclosed. A molecular data storage medium is presented comprising a header and a footer, each comprising or consisting of at least one unit of a first chemical species; and a sequence-controlled polymeric chain of a second chemical species located between said header and said footer, said polymeric chain encoding for a desired bitstream-format media. A nanopore-based device and methods for decoding digital information from the molecular data storage

IPC Classes  ?

• G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
• G16B 50/30 - Data warehousing; Computing architectures
• G16B 50/50 - Compression of genetic data

Abstract

The present invention relates to a DC/DC converter (1) for transferring an active power between two DC subsystems (5, 6) comprising: —a first converter stage (3) and a second converter stage (4) both configured to be selectively operated as an active inverter or as a passive rectifier; —an AC coupling circuit (2) for coupling the first and the second converter stage (3, 4) by means of an AC power transfer; and —a control unit (10) configured to switch the operation mode of the first and second converter stages (3, 4) depending on a measurement of an amount of power transfer through the AC coupling circuit (2).

IPC Classes  ?

• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion

Abstract

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

IPC Classes  ?

• C25F 3/12 - Etching of semiconducting materials
• B23H 9/14 - Making holes
• B23H 7/20 - Electric circuits specially adapted therefor, e.g. power supply for programme-control, e.g. adaptive
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• B23H 3/02 - Electric circuits specially adapted therefor, e.g. power supply, control, preventing short circuits
• C12Q 1/6869 - Methods for sequencing
• C25F 7/00 - Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objects; Servicing or operating
• G01N 27/447 - Systems using electrophoresis

Abstract

de novode novo bottom-up assembly and rational design of allosteric biosensors with programmable input-output behaviors that respond to soluble factors selectively enriched in tumors and trigger co-stimulation and cytokine signals. The disclosed method of effective mechanical coupling and biosensor signaling potency correlates with anti-tumor function. This disclosure provides synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.

IPC Classes  ?

• C07K 14/71 - Receptors; Cell surface antigens; Cell surface determinants for growth regulators
• C07K 14/725 - T-cell receptors
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to methods for the preparation of method of preparation of cDNA library based on one or many RNA samples useful for efficient RNA sequencing and uses thereof. The invention further relates to related tools and kits useful in said method.

IPC Classes  ?

• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present relates to a system for automated cell culture, the system comprising an inflow module, a cell culture plate and an outflow module, said inflow module being in fluid connection with the outflow module via the cell culture plate, the inflow module further comprising a microfluidic distribution module in fluid connection with the inflow module, the microfluidic distribution module being configured for controlling the distribution of a fluid flow from the inflow module to the cell culture plate, characterized in that the cell culture plate comprises at least one culture well configured for cell culture, and in that the system further comprises an adaptor coupled to the microfluidic distribution module, the adaptor being reversibly connectable to the cell culture plate so that when the adaptor is connected to the cell culture plate, the distribution of the fluid flow to said culture well is controlled by the microfluidic distribution module.

IPC Classes  ?

• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

The present invention relates to variants of the GAIN domain (G-protein-coupled receptor autoproteolysis-inducing domain) of an adhesion G protein-coupled receptor (ADGRG), such as a GAIN domain variant comprising or consisting of the amino acid sequence of the GAIN domain of ADGRG1 (Adhesion G Protein-Coupled Receptor G1) of SEQ ID NO: 1, wherein (i) one of amino acid positions (3) to (5), preferably amino acid position (4) and one of amino acid positions (47) to (49), preferably amino acid position (48) of SEQ ID NO: 1 are replaced by cysteines, (ii) one of amino acid positions (35) to (37), preferably amino acid position (36) and one of amino acid positions 180 to (182), preferably amino acid position (181) of SEQ ID NO: 1 are replaced by cysteines, (iii) one of amino acid positions (19) to (21), preferably amino acid position 20 and one of amino acid positions (124) to (126), preferably amino acid position (125) of SEQ ID NO: 1 are replaced by cysteines, (iv) one of amino acid positions (56) to (58), preferably amino acid position (57) and one of amino acid positions (65) to (67), preferably amino acid position (66) of SEQ ID NO: 1 are replaced by cysteines, (v) one of amino acid positions (16) to (18), preferably amino acid position (17) and one of amino acid positions (60) to (62), preferably amino acid position (61) of SEQ ID NO: 1 are replaced by cysteines, (vi) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine and the amino acid position at position (181) is replaced by arginine, (vii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine and the amino acid position at position (181) is replaced by arginine, (viii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, and the amino acid position at position (181) is replaced by arginine, (ix) the amino acid position at position (33) is replaced by tryptophane, the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, the amino acid position at position (178) is replaced by tyrosine, the amino acid position at position (181) is replaced by arginine, the amino acid position at position (184) is replaced by glycine, the amino acid position at position (186) is replaced by glutamine, and the amino acid position at position (187) is replaced by glycine, (x) the amino acid position at position (174) is replaced by isoleucine, (xi) the amino acid position at position (218) is replaced by alanine, or (xii) at least two of (i) to (xi) apply; or (B) comprising or consisting of an amino acid sequence sharing at least 80% sequence identity with the variant of (A), provided that the cysteines as defined in (A), item (i), (ii), (iii), (iv) and/or (v), or the amino acid replacement(s) as defined in (A), item (vi), (vii), (viii), (ix), (x) and/or (xi), or the cysteines and/or the amino acid replacement(s) as defined in (A), item (xii) are retained.

IPC Classes  ?

• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

The invention relates to a nanoplasma switch device, comprising: —multiple electrically isolated electrodes; —a gap separating the two electrodes; wherein the gap has a width which is dimensioned to effect the generation of a plasma by electric-field electron emission.

IPC Classes  ?

• H01J 17/06 - Cathodes
• H01T 4/10 - Overvoltage arresters using spark gaps having a single gap or a plurality of gaps in parallel

Abstract

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployable by eversion, said electrode structure (300) comprising: i) an elastic polymeric support (301) operatively connected to the reservoir's inlet (101) through a first end (302) and to the mechanical support (200) at a second end (303), and ii) at least one conductive track (400) disposed on a surface (S) of said elastic polymeric support (301).

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

It is disclosed a method for manufacturing an electrically conductive metal trace (1) comprising depositing metal micro or nano particles (2) in or on a substrate (3); removing an oxide layer (4) around the particles; sintering the particles after oxide layer removal to form the electrically conductive metal trace (1). The method is characterized in that the step of removing the oxide layer is an electrochemical process wherein the metal micro or nano particles are contacted by a reducing agent (5), and the step of sintering is heat sintering induced by light (6). The method is particularly suitable for manufacturing a transient electrically conductive metal trace.

IPC Classes  ?

• H05K 1/09 - Use of materials for the metallic pattern
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material

Abstract

ncii i = 1,2..., n,pii i = 1,2..., nSASmαjj j = 1,2,..., mL = [Rj,ij,i ]Rj,ij,i αjj pii Sn Vkiki tkk k = 1,2,...,S,V = [Vk,ik,i ]i = 1,2,...,nVkiki cii pii tkk rPk,hk,h tkk k = 1,2,..., sPk,hk,h h= 1,2,...,rPkk htkk D = [dh,ih,i ], DV = [Vk,ik,i ]P = [Pk,hk,h ]dh,ih,i hPk,hk,h iVk,ik,i tkk ΦDBFDBF= [φh,jh,j ], φh,jh,j hαjj Shαjj φh,jh,j ΦDBFDBF.

IPC Classes  ?

• A61B 5/294 - Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
• A61B 5/311 - Input circuits therefor specially adapted for particular uses for nerve conduction study [NCS]
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least one of the layers, that is not a top layer, constituting an information layer (9i) configured to be modified locally by energy from an electromagnetic beam (7) having a specific beam wavelength and a propagation direction (Z) transverse to the layers. The stacked plurality of layers include an aperiodic layer arrangement including at least three stacked adjacent layers having different thicknesses with respect to each other.

IPC Classes  ?

• G11B 7/24038 - Multiple laminated recording layers
• G11B 7/24067 - Combinations of two or more layers with specific interrelation
• G11B 7/242 - Record carriers characterised by the selection of the material of recording layers

Abstract

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation (DBS) System for providing Deep Brain Stimulation to brain tissue of a subject (P), - at least one control unit, configured and adapted to provide stimulation data, - at least one stimulation unit (12), operatively connected to the at least one control unit, the at least one stimulation unit (12) being configured and adapted to deliver epidural electrical stimulation (EES) to the dorsal side of the spinal cord (S) of said subject (P), and - at least one implantable pulse generator (IPG) (13), wherein the at least one stimulation unit (12) includes one or more electrodes (14) configured to be implanted epidurally, the one or more electrodes (14) being operatively connected to the at least one IPG (13).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The invention relates to oblique transscleral illumination of an eye fundus with at least one physical point light source around the eye allowing for dark field imaging combined with optical coherence tomography imaging

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
• G06T 7/50 - Depth or shape recovery

Abstract

The present invention concerns methods and devices for cultivating coenocytic algae and for producing cellulose, in particular microfibrillated cellulose (MFC). In one embodiment, the algae are grown on a solid substrate immersed in liquid culture medium. The solid substrate preferably comprises a carbonite mineral. The invention also concerns a method for producing spores of said coenocytic algae and a device comprising two separate containers, a first container for growing said algae and a second container for growing larger algae and inducing the generation of spores.

IPC Classes  ?

• A01G 33/00 - Cultivation of seaweed
• A01H 4/00 - Plant reproduction by tissue culture techniques
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 1/12 - Unicellular algae; Culture media therefor
• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

The present invention concerns a method for determining an estimated value for different parameters on the basis of one or more acquired signals obtained during a Magnetic Resonance Fingerprinting measurement. The method includes using a correction model and/or an iterative approach for improving the accuracy of the obtained estimated values.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A blood pressure monitor may be implanted without surgery. The blood pressure monitor may transmit real time blood pressure information to a receiver by wireless data transmission.

IPC Classes  ?

• A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

50607070270702707027070270270270237012011011021061231011031061011011010)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

IPC Classes  ?

• C07H 9/04 - Cyclic acetals
• C09K 23/00 - Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
• C11D 1/66 - Non-ionic compounds
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical

Abstract

A device and system for e.g. rehabilitation and assistance of hand motor functions, in particular a portable and under-actuated hand exoskeleton for use in activities of daily living, is disclosed.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global neural network model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local training dataset (DS1 to DSn) and a vector of output labels (OL1 to OLn) for training the global model. Further, it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the weights of the global model being encrypted with the collective public key. Each data provider (DP1) computes and aggregates, for each layer of the global model, encrypted local gradients (LG1) using the respective local training dataset (DS1) and output labels (OL1), with forward pass and backpropagation using stochastic gradient descent. At least one data provider homomorphically combines at least a subset of the current local gradients of at least a subset of the data providers into combined local gradients, and updates the weights of the current global model (GM) based on the combined local gradients.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
• H04L 9/08 - Key distribution

Abstract

An automated music composition and generation system for automatically harmonizing digital pieces of music using an automated music composition and generation engine for multi-voice music harmonization, including a system-user interface configured to input user parameters comprising at least an instrument designation, a composer style designation, an empty or partial input musical score to be automatically completed, whereby the instrument designation and the composer designation are any one of a predetermined list of instrument designations and composer designations, an automated music composition and generation engine configured to implement a generation strategy that produces playable and well-structured multi-voice music scores, operationally connected to the system-user interface, and a neural network module configured to implement a rhythm recurrent artificial neural network model, a melody recurrent artificial neural network model and a harmony feedforward neural network model that have been trained for combinations of the instrument designations and composer designations of the predetermined list.

IPC Classes  ?

• G10H 1/00 - ELECTROPHONIC MUSICAL INSTRUMENTS; INSTRUMENTS IN WHICH THE TONES ARE GENERATED BY ELECTROMECHANICAL MEANS OR ELECTRONIC GENERATORS, OR IN WHICH THE TONES ARE SYNTHESISED FROM A DATA STORE - Details of electrophonic musical instruments

Abstract

The present invention provides a method for preparing a sequencing library from a ribonucleic acid (RNA) sample.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

A device for fragmenting ions by collision induced dissociation, the device intended to be used together with a planar ion mobility apparatus, the device including a first conductive grid having a plurality of first openings, the first conductive grid configured for electric interconnection to a first electric potential, and a second conductive grid having a plurality of second openings, the second conductive grid configured for electric interconnection to a second electric potential, the first and second conductive grids being electrically insulated from each other.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/02 - Particle spectrometers or separator tubes - Details

Abstract

in silicode novo in silico in silico in silico based on the peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) of (e) an ensemble of peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) for which the lowest interface energy peptide-protein molecular complexes can be modelled, thereby obtaining engineered peptides and/or proteins being capable of forming a molecular complex with engineered binding characteristics.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural data; Docking or binding prediction

Abstract

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

IPC Classes  ?

• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The present invention concerns a waveguide amplifier comprising: - at least one embedding cladding material or layer, and - at least one rare-earth ion implanted silicon nitride material or layer embedded in the at least one embedding cladding material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core enclosed by the at least one embedding cladding material or layer.

IPC Classes  ?

• H01S 3/063 - Waveguide lasers, e.g. laser amplifiers
• H01S 3/16 - Solid materials
• H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups
• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light

Abstract

In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph includes identifying a directed functional edge of the functional subgraph based on presence of structural connection and directional communication of information across the same structural connection.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

A method for operating a light microscope comprises emitting and guiding a plurality of illumination light beams towards a specimen (6) to form a plurality of separated illumination light spots (2A, 2B, 2C, 2D) at the specimen; and guiding detection light beams (11) coming from the illumination light spots (2A, 2B, 2C, 2D) to a detector (10) comprising a plurality of sensor arrays (31-34). Each sensor array (31-34) comprises photon-counting detector elements (40), and detection light beams (11) from different illumination light spots (2A, 2B, 2C, 2D) are guided to different sensor arrays (31-34). Measured signals from the sensor arrays (31-34) are analysed to determine positional information about the light spots (15) on the sensor arrays (31 -34). It is adjusted where the light spots (15) hit the sensor arrays (31-34) based on the positional information. A corresponding light microscope is furthermore disclosed.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01J 1/44 - Electric circuits
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

M. smithiiM. smithiiM. smithiiM. smithii M. smithii M. smithii for promoting immune system homeostasis and intestinal health and for treating disorders associated with aberrant microbiota and/or archaea-deficiency.

IPC Classes  ?

• A61K 35/741 - Probiotics
• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/577 - Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies

Abstract

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• A61K 9/06 - Ointments; Bases therefor
• A61K 9/50 - Microcapsules

Abstract

CNG power system (1) comprising a storage tank (6) connected fluidically to a fuel conversion system (2) via an energy transfer system (4), the fuel conversion system (2) comprising a power unit using CNG as fuel and generating gas emissions comprising CO2, the fuel conversion system comprising a CO2 capture unit (16) configured for separating out CO2 from the gas emissions. The energy transfer system comprises a CNG expansion turbine (22) mounted in a fuel circuit (8) between the storage tank and fuel conversion system powered by expansion of the CNG flowing from the storage tank to the fuel conversion system, and a CO2 compressor (24) connected between the fuel conversion system and the storage tank along a CO2 circuit (10) for compressing the CO2, power for driving the CO2 compressor (24) being supplied in part by power generated by the CNG expansion turbine (22).

IPC Classes  ?

• F17C 13/00 - VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES - Details of vessels or of the filling or discharging of vessels

Abstract

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

IPC Classes  ?

• A61K 35/14 - Blood; Artificial blood
• A61K 38/45 - Transferases (2)
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C12N 5/09 - Tumour cells

Abstract

A haptic device is disclosed comprising at least one fluidic actuator operatively connectable with pumping means; and a plurality of movable members mechanically connected with said at least one fluidic actuator, wherein said movable members can perform a displacement upon actuation of the fluidic actuator and/or resist the movements of a body part of a user upon actuation of the fluidic actuator, to provide a tactile and/or force haptic sensation to a body part of a user. Methods for providing a haptic sensation to a user and receiving haptic input commands from a user are also disclosed.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising
• A61H 39/00 - Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/304 - Switching circuits

Abstract

A method for labelling a portion of a device includes the steps of providing a first substrate layer of a transparent or translucent material, depositing a first coloured material onto the first substrate layer in a labelling portion of the layer, thereby obtaining a labelling item, and coupling the labelling item to the device. The method is particularly suitable for producing labelled stretchable devices such as soft body-implantable devices for sensing a physiological signal and/or stimulating an electrical and/or pharmacological activity of a body tissue or organ in a subject.

IPC Classes  ?

• A61B 90/92 - Identification means for patients or instruments, e.g. tags coded with colour

Abstract

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for dimensionality reduction of time-series using contrastive learning. A method can include receiving multidimensional input time series data that includes data from a session or sessions that span time, selecting positive samples and negative samples from the multidimensional input time series data for respective reference samples from the multidimensional input time series data, wherein the positive samples and negative samples are each selected with a respective predetermined distribution across the time of the session or sessions of the multidimensional input time series, and mapping the reference samples, the positive samples, and negative samples into a common embedding space.

IPC Classes  ?

• G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning
• G06N 3/045 - Combinations of networks
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or bacterial infections or coinfection by virus and bacteria.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
• A61P 31/14 - Antivirals for RNA viruses
• C07D 405/00 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
• C07D 409/00 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

Abstract

The present disclosure relates to a method for generating variants of a protein based on a native protein regulated by allosteric pathway, the method comprising: i) providing 3D structures of the native protein; ii) identifying at least one pair of coupled allosteric sites within the amino acid sequence of the native protein named microswitch; iii) generating in silico mutations of said identified microswitch to generate a pool of variants; iv) computing at least one score reflecting the variation in allosteric coupling; and/or the variation in the relative stability v) predicting the activity of each variant compared to the native protein based on the computed score. The disclosure also concern a computer implemented program to carry out said method, and a variant of a protein or an active fragment thereof, a polynucleotide.

IPC Classes  ?

• C07K 14/72 - Receptors; Cell surface antigens; Cell surface determinants for hormones
• G16B 15/20 - Protein or domain folding
• G16B 15/30 - Drug targeting using structural data; Docking or binding prediction
• G16B 20/50 - Mutagenesis

Abstract

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 35/00 - Antineoplastic agents
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

A dielectrophoretic detection device including a chip, with a flow channel having at least one inlet and one outlet, and at least a detection area configured to detect analytes trapped on functionalised beads flowing within the flow channel, first and second electrode assemblies shaped as rows of parallel pillars extending a the height of the flow channel, and configured to generate under electric tension an electric field to form an electrical barrier, and preventing the beads to cross the barrier and drawing the beads to the detection area by dielectrophoretic forces where they are clustered and concentrated. The device may be provided with multiple rows of parallel pillars of electrode assemblies extending over the height of the flow channel, forming multiple concentration lines. The flow channel may be provided with further rows of parallel pillars of electrode assemblies crossing the flow channel in a transverse direction, forming further incubation lines.

IPC Classes  ?

• B03C 5/00 - Separating dispersed particles from liquids by electrostatic effect
• G01N 1/40 - Concentrating samples
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B03C 5/02 - Separators

Abstract

A force-feedback surface that creates and modulates distinctive profile and stiffnessto interact with a user in contact thereto, the surface being functionally independentto be used as a single module but can be customized to extend the application indiverse fields by assembling in series, parallel, or any combinations to form amultimodular system.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators

Abstract

A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a G protein or an arrestin protein in a cell.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.

IPC Classes  ?

• H04L 25/08 - Modifications for reducing interference; Modifications for reducing effects due to line faults
• H04B 10/54 - Intensity modulation
• H04B 7/0413 - MIMO systems
• H04L 25/02 - Baseband systems - Details
• H04L 25/49 - Transmitting circuits; Receiving circuits using three or more amplitude levels
• H04L 5/00 - Arrangements affording multiple use of the transmission path

Abstract

A computer-implemented inverse rendering method comprising: computing an adjoint image by differentiating an objective function that evaluates the quality of a rendered image, image elements of the adjoint image encoding the sensitivity of spatially corresponding image elements of the rendered image with respect to the objective function; sampling the adjoint image at a respective sample position to determine a respective adjoint radiance value associated with the respective sample position; emitting the respective adjoint radiance value into a scene model characterised by scene parameters; determining an interaction location of a respective incident adjoint radiance value with a surface and/or volume of the scene model; determining a respective incident radiance value or an approximation thereof at the interaction location; and updating a scene parameter gradient.

IPC Classes  ?

• G06T 15/00 - 3D [Three Dimensional] image rendering
• G06T 7/00 - Image analysis
• G06T 15/06 - Ray-tracing
• G06T 17/00 - 3D modelling for computer graphics
• G06T 15/50 - Lighting effects

Abstract

A method for producing a carbonate-containing species-rich, nitrogen-containing species-free solution from a urea-rich solution is proposed. The method comprising the steps of: providing a first reservoir comprising a first mixture including urea and a catalyser comprising an enzymatic catalyser and/or a microorganism; allowing an enzymatic reaction catalysed by the catalyser to decompose urea, thereby obtaining a second mixture comprising nitrogen-containing species and carbonate-containing species; converting at least some of the nitrogen-containing species into gaseous nitrogen-containing species to obtain a third mixture comprising the gaseous nitrogen-containing species and the carbonate-containing species; filtering the third mixture by a gas- permeable filter, thereby separating at least some of the gaseous nitrogen-containing species from the carbonate-containing species while keeping the catalyser away from the gas-permeable filter; and collecting the so-obtained carbonate-containing species-rich, nitrogen-containing species-free solution.

IPC Classes  ?

• C09K 17/10 - Cements, e.g. Portland cement
• C04B 12/00 - Cements not provided for in groups
• C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides
• E02D 3/12 - Consolidating by placing solidifying or pore-filling substances in the soil

Abstract

The present invention concerns a method for producing at least one ferroelectric device or structure comprising the steps of providing at least one ferroelectric material or layer, or providing at least one ferroelectric material or layer to be patterned or structured; depositing at least one adhesion layer on a first side of the at least one ferroelectric material or layer; and depositing at least one diamond-like carbon layer or material on the at least one adhesion layer.

IPC Classes  ?

• G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
• G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
• G02F 1/05 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect with ferro-electric properties

Abstract

1233)+n1233 are independently selected from a hydrocarbyl group containing 1-40 carbon atoms said hydrocarbyl group, if said hydrocarbyl group comprises 3 or more carbons, may be linear or branched; and W is an anion.

IPC Classes  ?

• H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation

Abstract

ssTRTRR).

IPC Classes  ?

• G01S 7/288 - Coherent receivers
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G01S 13/28 - Systems for measuring distance only using transmission of interrupted, pulse modulated waves wherein the transmitted pulses use a frequency- or phase-modulated carrier wave with time compression of received pulses
• G01S 17/36 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
• G01S 17/86 - Combinations of lidar systems with systems other than lidar, radar or sonar, e.g. with direction finders

Abstract

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local model (LM1 to LMn) and a respective local training dataset (DS1 to DSn) for training the local model using an iterative training algorithm (IA). Further it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the local and global model being encrypted with the collective public key. Each data provider (DP1) trains its local model (LM1) using the respective local training dataset (DS1) by executing gradient descent updates of its local model (LM1), and combining (1340) the updated local model (LM1′) with the current global model (GM) into a current local model (LM1c). At least one data provider homomorphically combines at least a subset of the current local models of at least a subset of the data providers into a combined model (CM1), and updates the current global model (GM) based on the combined model. The updated global model is provided to at least a subset of the other data providers.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61F 2/12 - Mammary prostheses
• A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/24 - Collagen
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61K 9/14 - Particulate form, e.g. powders
• A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Abstract

Electronic metadevice comprising a conductive channel; a metal layer superposed on the conductive channel; and a barrier layer located between the metal layer and the conductive channel. The metal layer includes at least one recess extending through the metal layer to define at least one metallic metastructure comprising at least one first metal layer portion adjacent to at least one second metal layer portion. The recess extends through the metal layer to define a micro-structured or a nano-structured first metal layer portion comprising at least one first metallic extension or finger extending away from a first support of the first metal layer portion towards the second metal layer portion; and a micro-structured or a nano-structured at least one second metal layer portion comprising at least one second metallic extension or finger extending away from a second support of the second metal layer portion towards the first metal layer portion.

IPC Classes  ?

• H01L 29/86 - Types of semiconductor device controllable only by variation of the electric current supplied, or only the electric potential applied, to one or more of the electrodes carrying the current to be rectified, amplified, oscillated, or switched
• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or

Abstract

A micro- or nanostructured optical element (1) is proposed comprising: a membrane (3) with an array of holes (5), the membrane (3) comprising a membrane light wave facing surface; an array of pillars (7) sized and shaped such that a respective pillar (7) is configured to be at least partially received in a respective hole (5), the respective pillar (7) defining a central pillar axis, and comprising a pillar light wave facing surface; a support (9) configured to support the pillars (7); and an actuation mechanism configured to selectively generate a relative displacement between the membrane (3) and the pillars (7) along the central pillar axes to thereby define a first optical element reflectance state, where the membrane (3) is in an elevated position with respect to the support (9), and a second, different optical element reflectance state, where the membrane (3) is in a lowered position with respect to the support (9) such that the respective pillar (7) extends through the respective hole (5). In the first optical element reflectance state, the membrane light wave facing surface is substantially flush with the pillar light wave facing surfaces, or the membrane light wave facing surface is placed beyond the pillar light wave facing surfaces.

IPC Classes  ?

• G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements

Abstract

A hollow variable stiffness thread including a flexible inner tube, a conductive shape memory polymer (CSMP) layer arranged around the inner tube forming a variable stiffness zone, a flexible encapsulation layer arranged around the CSMP layer, and a first electrode and a second electrode, at least a portion of the first and the second electrodes being in contact with the CSMP layer.

IPC Classes  ?

• A61B 18/14 - Probes or electrodes therefor
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/00 - Catheters; Hollow probes
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets

Abstract

Compounds, compositions and methods that can be used for the treatment of viral diseases are provided.

IPC Classes  ?

• A61P 31/12 - Antivirals
• C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
• A61P 37/02 - Immunomodulators
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A smart wearable (SW) for collecting data on an integrity of a joint of a wearer, the wearable including a first frame (1) configured to be attached in proximity of the joint of the wearer, the frame (1) including an elastic sensor frame (3) having an open cavity (21) configured to be attached to an area of interest of the joint, a kinematic sensor device (19) configured to measure kinematics of the joint, and acoustic sensor device (13) arranged in the cavity (21) configured to capture airborne acoustic emissions from the area of interest, and a data processor device (18) configured to receive and record data from the kinematic sensor device (19) and from the acoustic sensor device (13).

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The disclosure relates to dendritic polyglycerols (dPG) compounds with carboxyalkyl, sulfyl or sulfonyl functional groups that irreversibly inhibit viral infection (virucidal effect) through multivalent interaction in nanomolar concentration range. While the compounds of the disclosure show virus inhibition in the nanomolar range they show no in-vitro toxicity in the same range of concentration.

IPC Classes  ?

• A61K 31/765 - Polymers containing oxygen
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• A01N 31/02 - Acyclic compounds
• A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof
• A61P 31/14 - Antivirals for RNA viruses
• A61K 31/795 - Polymers containing sulfur
• A01N 41/04 - Sulfonic acids; Derivatives thereof
• C08G 65/48 - Polymers modified by chemical after-treatment

Abstract

A method for enforcing smoothness constraints on surface meshes produced by a Graph Convolutional Neural Network (GCNN) including the steps of reading image data from a memory, the image data including two-dimensional image data representing a three-dimensional object or a three-dimensional image stack of the three-dimensional object, performing a GCNN mesh deformation step on the image data to obtain an approximation of a surface of the three-dimensional object, the surface represented by triangulated surface meshes, at least some vertices of the triangulated surface meshes having a different number of neighboring vertices compared to other vertices in a same triangulated surface mesh, and performing a deep active surface model (DASM) transformation step on the triangulated surface meshes to obtain a corrected representation of the surface of three-dimensional object to improve smoothness of the surface.

IPC Classes  ?

• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A photonic assembly, a laser setup comprising said photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using said laser setup are disclosed. The photonic assembly (1) comprises an active photonic chip (10), a photonic modulator chip (2) comprising a photonic circuit arrangement, and a tuning arrangement comprising a modulation element (33) having a thickness of 10 micrometers or less. The active photonic chip (10) and the photonic modulator chip (2) are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip (10). The modulation element (33) is arranged such, that an actuation of the modulation element (33) tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

IPC Classes  ?

• H01S 3/107 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using electro-optic devices, e.g. exhibiting Pockels or Kerr effect
• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
• H01S 3/11 - Mode locking; Q-switching; Other giant-pulse techniques, e.g. cavity dumping
• H01S 5/14 - External cavity lasers

Abstract

The present invention is related to a stretchable tubular device (1) comprising at least one layer (Lx) of a stretchable polymer, a power supply (2) and a set of electrodes (3a, 3b) connected to said power supply (2). The power supply can supply at least a first level of voltage (V1) to the electrodes so as to modify the natural force (F0) of the stretchable layers to a modified force (F1). The present invention also covers a process for manufacturing such a tubular device and its use as a medical implant.

IPC Classes  ?

• A61M 60/148 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• A61M 60/486 - Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance - Details relating to driving for devices for mechanical circulatory actuation the force acting on the actuation means being mechanical, e.g. mechanically driven members clamping a blood vessel generated by electro-active actuators, e.g. using electro-active polymers or piezoelectric elements
• A61M 60/531 - Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors