Abrégé

A modular multiple frequency coils inductive link system to wirelessly provide power for at least a medical implant at an output of a receiving coil, whereby the receiving coil is configured to be implanted in an organism. The modular multiple frequency coils inductive link comprises a transmitter coil configured to input power from a power supply and induce a first magnetic field at a resonating carrier frequency. The modular multiple frequency coils inductive link further comprises a shifting resonator comprising at least an active integrated circuit, a first coil configured to receive the first induced magnetic field from the transmitter coil by induction at the resonating carrier frequency and convert it to an electrical current, and a second coil configured to transmit the electrical current to the receiving coil by inducing a second magnetic field at a determined frequency different from the resonating carrier frequency, the active integrated circuit connected with both the first coil and the second coil and being configured to receive the power induced at the resonating carrier frequency though the first coil and to use it to drive remaining power reduced due to a power dissipation of the active integrated circuit at the determined frequency though the second coil. The receiving coil is configured to receive the power induced by the second coil at the determined frequency and make it available at the output of the receiving coil.

Classes IPC  ?

• H01F 38/00 - Adaptations de transformateurs ou d'inductances à des applications ou des fonctions spécifiques
• H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

The invention relates to an Imaging sensor device in a stacked arrangement comprising: - a pixel array tier comprising a plurality of pixel segments each having a plurality of pixels for photon detection each providing a digital pixel output; - a processing tier comprising a number of processing cores each associated with one of the plurality of pixel segments to receive the pixel outputs of the pixels of the respective pixel segment, wherein the processing cores are each in bidirectional communication with one or more neighboring processing cores, wherein the processing cores are each configured to receive pixel outputs of the pixels of the associated pixel segments and to distribute processing of pixel outputs between the processing core and the at least one of the neighboring processing cores as neighboring processing cores.

Classes IPC  ?

• H04N 25/78 - Circuits de lecture pour capteurs adressés, p. ex. amplificateurs de sortie ou convertisseurs A/N
• H04N 25/79 - Agencements de circuits répartis entre des substrats, des puces ou des cartes de circuits différents ou multiples, p. ex. des capteurs d'images empilés
• H04N 25/773 - Circuits de pixels, p.ex. mémoires, convertisseurs A/N, amplificateurs de pixels, circuits communs ou composants communs comprenant des convertisseurs A/N, V/T, V/F, I/T ou I/F comprenant des circuits de comptage de photons, p. ex. des diodes de détection de photons uniques [SPD] ou des diodes à avalanche de photons uniques [SPAD]

Abrégé

A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/374 - Détection de la répartition de fréquence dans les signaux, p.ex. détection des ondes delta, thêta, alpha, bêta ou gamma

Abrégé

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross-sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.

Classes IPC  ?

• A61B 8/06 - Mesure du débit sanguin
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

A micromachined mechanism for a sensing tool includes a support, a probe pivotally mounted with respect to the support, and a beam connected to the support and the probe. The probe is configured to apply a load (Ftool) on a body and to be subjected to a counter-reaction contact force exerted by the body in reaction to the load. The beam is configured to shift from an undeformed position to a deformed position when the contact force of the body is greater than a predetermined threshold force (Fcrit) for which the beam buckles.

Classes IPC  ?

• A61B 5/12 - Audiométrie
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection.

Classes IPC  ?

• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

The present invention concerns a method of manoeuvring a vertical take-off and landing, unmanned aerial drone (100) comprising at least an aerodynamic surface (101), wherein, during a flight of the drone, the aerodynamic surface generates lift and/or drag and an aerodynamic surface area is dynamically varied to compensate for adverse wind currents and/or to use said wind currents and/or to use an effective airspeed velocity as an assistance in manoeuvring the drone flight, said aerodynamic surface area variations allowing to reduce an energy consumption of the drone.

Classes IPC  ?

• B64C 3/54 - Variation de la surface alaire
• B64U 10/20 - Aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
• B64U 30/12 - Ailes variables ou détachables, p. ex. ailes à flèche réglable

Abrégé

The present disclosure concerns a membrane-less electrolyzer comprising a first electrode and a second electrode, a first fluidic channel configured to receive an electrolyte, a second fluidic channel configured to receive the electrolyte from the first fluidic channel, a third fluidic channel configured to receive the electrolyte from the first fluidic channel. The first fluidic channel being in fluidic communication with the second and third fluidic channels. The first fluidic channel is connected to the second and third fluidic channels via a plurality of inclined fluidic canals extending from the first fluidic channel to each of the second and third fluidic channels.

Classes IPC  ?

• C25B 11/03 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes

Abrégé

A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque

Abrégé

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades.

Classes IPC  ?

• A61K 38/20 - Interleukines
• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61P 35/00 - Agents anticancéreux

Abrégé

A method for aggregating digital signatures comprises the following steps carried out by a signature aggregator: receiving first data packages from signers, each first data package comprising a signer identifier, a payload, and a payload signature; verifying the payload signatures to determine whether or not the payloads are correctly signed; bundling correctly signed payloads into a batch; obtaining a batch digest, and proofs of inclusion of the payloads in the batch; sending second data packages comprising the batch digest and a respective proof of inclusion to the signers, the respective proof of inclusion proving that the payload of the respective signer is included in the batch; receiving third data packages from the signers, each third data package comprising the signer identifier, and a respective batch digest signature; verifying the batch digest signatures to determine whether or not the batch digests are correctly signed; aggregating correctly signed batch digest signatures to obtain an aggregated batch digest signature; and including the aggregated batch digest signature in the batch. The payload and batch digest signatures may be obtained by using different secret keys of the respective signer.

Classes IPC  ?

• G06F 21/64 - Protection de l’intégrité des données, p.ex. par sommes de contrôle, certificats ou signatures
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

Classes IPC  ?

• A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
• A61F 9/00 - Procédés ou dispositifs pour le traitement des yeux; Dispositifs pour mettre en place des verres de contact; Dispositifs pour corriger le strabisme; Appareils pour guider les aveugles; Dispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
• F04B 43/04 - Pompes ayant un entraînement électrique
• F04B 43/09 - Pompes à entraînement électrique
• F04B 43/12 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles à action péristaltique
• F04B 43/14 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles à action péristaltique ayant des organes flexibles du genre plat

Abrégé

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or within at least a portion of said substrate; ii) a stretchable interconnect comprising an intrinsically elastic substrate, said substrate comprising at least one well or groove comprising at least one compliant conductive element therein, said at least one well or groove being configured to accommodate said at least one conductive track of said interconnection board; and iii) at least one bolus of an electrically conductive paste located within said at least one well or groove, configured to electrically connect said at least one compliant conductive element with said at least one conductive track.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• H05K 1/03 - Emploi de matériaux pour réaliser le substrat
• H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
• H05K 3/10 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché
• H05K 3/38 - Amélioration de l'adhérence entre le substrat isolant et le métal

Abrégé

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so called old mRNA and such differences compared to control cell assays. The invention is applicable for screening in particular candidate ligand molecules such as antibodies for an effect on target cells, and thereby provides new strategies for the identification of therapeutically active compounds.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes

Abrégé

244.

Classes IPC  ?

• C10L 3/06 - Gaz naturel; Gaz naturel de synthèse obtenu par des procédés non prévus dans , ou
• C10L 3/08 - Production de gaz naturel de synthèse
• C10L 3/10 - Post-traitement de gaz naturel ou de gaz naturel de synthèse
• F17D 1/04 - Systèmes de canalisation pour gaz ou vapeurs pour la distribution du gaz

Abrégé

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property and configured to cover a molar tooth, and an internally exposed intermediate region defined by a third material property and configured to be located between the occlusional cushioning region and the impact protective region, wherein said first, second and third material properties are different. A corresponding method of fabricating a mouthguard is also described.

Classes IPC  ?

• A63B 71/08 - Moyens protecteurs du corps pour joueurs ou sportifs
• B33Y 10/00 - Procédés de fabrication additive

Abrégé

A fin field-effect transistor (FinFET) based semiconductor memory array having a plurality of memory cells, each memory cell including a write transistor having a write wordline gate over a first fin connected to a write wordline gate contact, a write bitline contact in connection with the first fin, and a storage node contact in connection with the first fin, and a read transistor having a storage node gate over a second fin, the storage node gate connected to a storage node gate contact, the storage node gate contact connected to the storage node contact, a read wordline contact in connection with the second fin, and a read bitline contact in connection with the second fin, wherein the write wordline gate and the storage node gate are arranged in series to each other along an extension axis that coincides with an longitudinal axis of the write wordline gate and a longitudinal axis of the storage node gate.

Classes IPC  ?

• G11C 11/419 - Circuits de lecture-écriture [R-W]
• G11C 11/412 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des dispositifs à semi-conducteurs utilisant des transistors formant des cellules avec réaction positive, c. à d. des cellules ne nécessitant pas de rafraîchissement ou de régénération de la charge, p.ex. multivibrateur bistable, déclencheur de Schmitt utilisant uniquement des transistors à effet de champ
• H01L 27/11 - Structures de mémoires statiques à accès aléatoire
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
• H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée

Abrégé

A water permeation sensor suitable for monitoring and quantitatively assessing ultra-low permeability of thin film encapsulations engineered for bioelectronic microdevices, its fabrication as well as device comprising the same are disclosed herein.

Classes IPC  ?

• A61B 5/263 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/266 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des électrolytes, gels ou pâtes conducteurs

Abrégé

[0054] Methods are provided for estimating key reliably and accurately predicting cardiac output using a limited set of non-invasively monitored physiologic inputs, and a calibrated one- dimensional arterial tree model, a database of synthetic data generated from such a model, and an artificial intelligence module. Systems for estimating CO based on non-invasively measured physiologic inputs also are provided that may be implemented without the need for extensive real-time computing resources.

Classes IPC  ?

• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
• A61B 5/029 - Mesure du débit de sang à la sortie du cœur, p.ex. volume éjecté par minute

Abrégé

A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., wherein each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from said method are also disclosed.

Classes IPC  ?

• A61L 27/52 - Hydrogels ou hydrocolloïdes
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B33Y 80/00 - Produits obtenus par fabrication additive
• B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p.ex. de buses de jet
• B29C 64/245 - Plates-formes ou substrats
• A61L 27/56 - Matériaux poreux ou cellulaires
• B29C 64/00 - Fabrication additive, c. à d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p.ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
• B29C 35/16 - Refroidissement
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

Produits et services

Databases (electronic), in relation to the following fields: Apiculture; Intelligent systems for controlling honey production in beehives; Software for planning, integrating and optimising smart hive applications; Intelligent gateways for real-time data analysis, in relation to the following fields: Apiculture and Bee behaviour; Intelligent gateways for data pre-processing, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Intelligent portals for software-defined data storage related to beekeeping and bee behaviour, health and honey production; Software for monitoring, analysing, controlling and managing bees in hives; Intelligent software for the production related to the production of honey from bees; Computers for controlling control devices for bees and hives; Computer software for biometric systems for bee identification and authentication; Downloadable computer software for remote monitoring and analysis, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Computer software for collecting bee positioning data; Application software for robot bees; Smart hive application software, smart hive automation software; Software for automating the production process in intelligent hives; Software for controlling the movement of bees; Environmental control software; Process controlling software, in relation to the following fields: Apiculture; Software for controlling processes in intelligent hives; Environmental monitoring software; Software for optical bee recognition; Laboratory robot bees; Training robot bees; Scientific research and laboratory apparatus, educational apparatus and simulators; Apparatus and instruments for scientific research purposes and Laboratory apparatus and Apparatus for laboratories, Teaching apparatus and Teaching apparatus and Simulators for training courses, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Measuring, detecting, monitoring and controlling devices; Devices for measuring, detecting, monitoring and controlling bees; Apparatus for biometric identification of bees; Weather information apparatus; Teaching and instructional apparatus, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Biochips; Temperature sensing apparatus for scientific use, in relation to the following fields: Apiculture; Instructional and teaching apparatus and instruments, in relation to the following fields: Apiculture; Electronic instructional and teaching apparatus and instruments, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Teaching apparatus, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Instrumentation simulators, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Sensors, detectors and devices for monitoring bees in smart hives; Data loggers and recorders, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Testing and quality control devices; Controllers and regulators relating to beekeeping and bee behaviour, health and honey production; Measuring devices, in relation to the following fields: Apiculture, The behaviour, health status and honey production of bees; Air analysis apparatus; Monitoring instruments, in relation to the following fields: Apiculture and The behaviour, health status and honey production of bees; Automated bee detection systems; Computerised bee behaviour and health analysers; Computer hardware for monitoring the behaviour of winners; Tools for analysing bee behaviour, health and honey production; Beehive automation systems; Digital bee locator apparatus; Digital indicators, in relation to the following fields: Apiculture and Bee behaviour, health, location and honey production; Apparatus and instruments for physics; Image analyzers, in relation to the following fields: Apiculture and Bee behaviour, health, location and honey production; Beehive automation devices; Devices and tools for checking (supervision, control) of beehives; Video surveillance apparatus for bees [electronic]; Bee global positioning apparatus; Video monitoring apparatus for bees [satellite]; Bee flight control apparatus; Navigation, guidance, tracking, targeting and map making devices, in relation to the following fields: Bees and robot bees; Infrared bee locators and robot bees; Gyrocompasses; Electronic tags for bees and robot bees; Electronic navigation systems, in relation to the following goods: Robot bees; Navigating apparatus (Electronic -), for use in relation to the following goods: Robot bees; Electronic tracking apparatus and instruments, in relation to the following fields: Bees and robot bees; Sensors for determining position, in relation to the following fields: Bees and robot bees; Optical position sensors, for use in the following fields: Bees and robot bees; Optical apparatus for locating bees and bee robots; Tracking devices, for use in the following fields: Bees and robot bees; Robot bees. Beehives; Artificial honeycombs for beehives; Sections of wood for beehives; Intelligent (smart) beehives; Automated beehives. Data mining, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Professional consultancy relating to technology, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Science and technology services, in relation to the following fields: beekeeping, Breeding and reproduction of bees; IT services, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services, in relation to the following fields: Design of machines for beekeeping, breeding and reproduction of bees; Engineering services relating to information technology, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to automatic data processing, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to the design of communications systems, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering design and consultancy, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Consultancy services relating to product engineering, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Computer-aided engineering design services relating to beekeeping, reproduction and breeding; Technology assessments relating to beekeeping, breeding and reproduction provided by engineers; Testing, authentication and quality control, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Analysis and evaluation of product development, in relation to the following fields: beekeeping, Breeding and reproduction of bees; Engineering services relating to robotics, in relation to the following fields: beekeeping, Breeding and reproduction of bees; inspecting, in relation to the following fields: Bee breeding; Investigations, in relation to the following fields: Bee breeding; Tests, in relation to the following fields: Bee breeding; Development, in relation to the following goods: Computer hardware relating to beekeeping, breeding and reproduction of bees; Development, Programming and Implementation, in relation to the following goods: Computer software relating to beekeeping, breeding and reproduction of bees; Research relating to the development of computer hardware relating to beekeeping, breeding and reproduction of bees; Consultancy and information, in relation to the following fields: Design and development of computer hardware relating to beekeeping, breeding and reproduction of bees; Design of computer hardware for the beekeeping, breeding and reproduction of bees industry; Design of computer hardware and software.

Abrégé

ESP particle collector (1) for collecting particles in a particle containing gas stream, comprising an inlet section (4), a collector section (6), and an electrode arrangement (8), the inlet section comprising a flow tube (10) defining a gas flow channel (12) therein bounded by a guide wall (24) extending between an entry end (14) and a collector end (16) that serves as an inlet to the collector section (6), the entry end comprising an inlet (28) for the particle gas stream and a sheath flow inlet portion (26) for generating a sheath flow around the particle gas stream, the collector section comprising a housing (18) coupled to the flow tube, and a collector plate (20) mounted therein having a particle collection surface (23). The ESP particle collector is configured to allow optical analysis of the collector plate particle collection surface to measure particles collected thereon. The electrode arrangement comprises at least a base electrode (8a) positioned below the collection surface and a counter-base electrode (8b) positioned at a separation distance L2 above the collection surface such that an electrical field is generated between the electrodes configured to precipitate said particles on the collection surface, wherein the electric field is in a range of 0.1 kV per mm to 1.5 kV per mm, with an absolute voltage on any said electrode that is less than 10 kV, and wherein a ratio ratio I of a radius L1 of said inlet at the collector end divided by said separation distance L2 is in a range of 0.8 to 1.2.

Classes IPC  ?

• B03C 3/06 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par la présence d'électrodes tubulaires fixes
• B03C 3/49 - Electrodes collectrices tubulaires
• B03C 3/38 - Postes de chargement ou d'ionisation des particules, p.ex. utilisant des décharges électriques, des radiations radioactives ou des flammes
• B03C 3/36 - Séparation par effet électrostatique des particules dispersées des gaz ou de la vapeur, p.ex. dans de l'air - Parties constitutives ou accessoires, ou leur fonctionnement commandant le débit de gaz ou de vapeurs

Abrégé

Disclosed is a flexure pivot based system being one of: a force sensor, a force limiting device arranged to exert a predetermined threshold force, a torque limiting device arranged to exert a predetermined threshold torque, a programmable mechanical memory, or an accelerometer, the flexure pivot based system including a substantially rigid frame supporting a lever by a suspension mechanism including: a first flexure extending from the frame to a junction with the lever; a second flexure extending from the frame to the junction at a first non-zero angle to the first flexure in a neutral position of the suspension mechanism; and a third flexure extending from the junction to a preloading system at a second non-zero angle to the first flexure and/or the second flexure in the neutral position, the preloading system applying a force in a direction substantially coaxial with the third flexure.

Classes IPC  ?

• G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques

Abrégé

Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treating aneurysms in challenging anatomy such as the thoracic aorta. The compliant vascular grafts preferably have an outer frame layer and an inner graft layer with a plurality of pleats to permit expansion.

Classes IPC  ?

• A61F 2/06 - Vaisseaux sanguins
• A61F 2/07 - Endoprothèses déployables couvertes

Abrégé

A scintillation device including a silicon plate having a rectangular shape and having a first side and a second side opposite the first side, wherein the first side includes a plurality of first channels arranged to be in parallel with each other extending in a first direction, wherein walls in the silicon plate that form the first channels are coated with an optically reflective or dielectric layer, and wherein the first channels are filled with a scintillation resin in a solid state forming a first waveguide.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/203 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant fait de matières plastiques

Abrégé

A method for manufacturing a scintillation detector structure including the steps of forming a plurality of first structures into a surface of a substrate to form a patterned substrate, filling the plurality of first structures and covering the surface of the substrate with a polymeric material, hardening the polymeric material and first removing the hardened polymeric material from the substrate to obtain a polymeric mold with a patterned surface having a plurality of second structures, performing a surface cleaning treatment and a silanization of the patterned surface of the polymeric mold, filling the plurality of second structures and covering the patterned surface of the polymeric mold with a moldable scintillation material, polymerizing the scintillation material while exerting a pressure on the scintillation material, and second removing the polymerized scintillation material from the plurality of second structures of the polymeric mold to obtain scintillation detector active structures.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
• C08L 83/04 - Polysiloxanes
• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• B29C 33/40 - Matière plastique, p.ex. mousse ou caoutchouc

Abrégé

The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation Δ ⁢ E = f E ⁢ hc λ ⁢ N ⁢ or ⁢ Δ ⁢ E = f E ⁢ E p N .

Classes IPC  ?

• H01J 37/22 - Dispositifs optiques ou photographiques associés au tube
• H01J 37/244 - Détecteurs; Composants ou circuits associés
• H01J 37/28 - Microscopes électroniques ou ioniques; Tubes à diffraction d'électrons ou d'ions avec faisceaux de balayage
• H01J 37/20 - Moyens de support ou de mise en position de l'objet ou du matériau; Moyens de réglage de diaphragmes ou de lentilles associées au support

Abrégé

Herein described are diaryl ether compounds having the structure (I) as well as a method for their manufacture from lignin.

Classes IPC  ?

• C07C 47/575 - Composés comportant des groupes —CHO liés à des atomes de carbone de cycles aromatiques à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
• C07C 69/92 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons d'acides hydroxycarboxyliques monocycliques dont les groupes hydroxyle et les groupes carboxyle sont liés à des atomes de carbone d'un cycle aromatique à six chaînons avec des groupes hydroxyle éthérifiés

Abrégé

The invention provides an in vitro method for the cell-free quantification of virus neutralizing activity, such as the SARS-CoV-2 neutralizing activity, of biological samples and kit for carrying out the method. The invention also provides a method of screening biological samples or collections of molecules to identify neutralizing antibodies or antiviral drugs.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

Electrolyser including a reactor (2) comprising a housing (4), fluidic channels (6a, 6b, 6c) within the housing, and electrodes (16a, 16c) comprising an anode (16a) and a cathode (16c). The fluidic channels include an inter-electrode channel (6b) arranged between the anode (16a) and cathode (16c) and connected to an anode channel inlet (8a) for injection of an electrolyte into the inter-electrode channel (6b), a cathode channel (6c) separated from the inter-electrode channel (6b) by a porous cathode side wall (14c) comprising a plurality of canals (20), and an anode channel (6a) separated from the inter-electrode channel (6b) by a porous anode side wall (14a) comprising a plurality of canals (20). Each canal has a tapered shape such that an inlet surface area (Si) of the canal is greater than an outlet surface area (So) of the canal, the inlet surface area being on a side of the porous walls bounding the inter-electrode channel (6b).

Classes IPC  ?

• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 9/21 - Cellules comprenant des électrodes fixes de dimensions stables; Assemblages de leurs éléments de structure avec des diaphragmes avec plusieurs diaphragmes
• C25B 11/03 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées
• C25B 13/02 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Éléments d'espacement caractérisés par la configuration ou la forme

Abrégé

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions or methods using IL-4, a fragment or variant thereof, fused to a moiety, to increase the efficacy of an anti-cancer immunotherapy or an autoimmune therapy.

Classes IPC  ?

• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61K 38/20 - Interleukines
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament
• C07K 14/54 - Interleukines (IL)

Abrégé

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by between-assembly links, each node assembly itself comprising a network of nodes interconnected by a plurality of within-assembly links, wherein each of the between-assembly links and the within-assembly links have an associated weight, each weight embodying a strength of connection between the nodes joined by the associated link, the nodes within each assembly being more likely to be connected to other nodes within that assembly than to be connected to nodes within others of the node assemblies.

Classes IPC  ?

• G06N 3/045 - Combinaisons de réseaux
• G06N 3/082 - Méthodes d'apprentissage modifiant l’architecture, p.ex. par ajout, suppression ou mise sous silence de nœuds ou de connexions
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, the step of predicting at least one target buried interface site comprises generating at least one surface fingerprint associated with a protein interaction based on at least one protein interface, wherein the at least one surface fingerprint preferably embeds geometric and/or chemical features of molecular surfaces, identifying at least one binding seed that displays required features to engage the target site, and performing a binding seed transplantation to protein scaffolds to confer stability and additional contacts on the designed interface.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
• G16B 20/30 - Détection de sites de liaison ou de motifs
• G16B 40/20 - Analyse de données supervisée

Abrégé

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition in a subject by administering an engineered progenitor cell or an engineered cell differentiated from an engineered progenitor cell of the present disclosure.

Classes IPC  ?

• C12N 5/0784 - Cellules dendritiques; Leurs progéniteurs

Abrégé

Nanopore-based scanning system including a probe structure comprising a nanopore; suction means configured to draw an end of a (bio)molecule inside the nanopore and inside the probe structure, single or multiple times; and displacement means configured to mechanically displace the probe structure and the nanopore relative to the one (bio)molecule along a direction following a direction of extension of the (bio)molecule while the (bio)molecule is located inside the nanopore and inside the probe structure, or configured to mechanically displace at least one support holding the (bio)molecule relative to the nanopore along a direction following a direction of extension of the (bio)molecule while holding the at least one support and while the (bio)molecule is located inside the nanopore.

Classes IPC  ?

• B01L 3/02 - Burettes; Pipettes
• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
• C12Q 1/6869 - Méthodes de séquençage
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01Q 60/44 - Microscopie à conductance ionique à balayage SICM [Scanning Ion-Conductance Microscopy] ou appareils à cet effet, p.ex. sondes SICM

Abrégé

The present invention concerns an electrolysis system for high temperature electrolysis including a plurality of flow-based electrolysis units configured to receive an electrolyte solution and to perform electrolysis to provide a first output gas and a second output gas, the plurality of flow-based electrolysis units being membrane-less electrolysis units; at least one heating mechanism or means for heating the electrolyte solution to undergo electrolysis; a first gas separator and a second gas separator configured to remove the first output gas and the second output gas from the electrolyte solution; and an encasement or a cell enclosing the plurality of flow-based electrolysis units, the encasement or the cell being configured to support a pressure of the electrolyte solution permitting to increase a boiling point of the electrolyte solution to a temperature between 96°C and 350°C.

Classes IPC  ?

• C25B 1/042 - Hydrogène ou oxygène par électrolyse de l'eau par électrolyse de la vapeur
• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 9/60 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Éléments de structure des cellules; Assemblages d'éléments de structure, p.ex. assemblages d'électrode-diaphragme; Caractéristiques des cellules relatives aux procédés Éléments de structure des cellules
• C25B 9/67 - Moyens de chauffage ou de refroidissement
• C25B 9/70 - Assemblages comprenant plusieurs cellules
• C25B 11/031 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées Électrodes poreuses
• C25B 11/046 - Alliages
• C25B 15/025 - Paramètres de l’électrolyte
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes

Abrégé

Systems and methods for data storage and readout using hybrid nucleic acid-polymeric molecules are herein disclosed. A molecular data storage medium is presented comprising a header and a footer, each comprising or consisting of at least one unit of a first chemical species; and a sequence-controlled polymeric chain of a second chemical species located between said header and said footer, said polymeric chain encoding for a desired bitstream-format media. A nanopore-based device and methods for decoding digital information from the molecular data storage

Classes IPC  ?

• G11C 13/02 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments dont le fonctionnement dépend d'un changement chimique
• G16B 50/30 - Entreposage de données; Architectures informatiques
• G16B 50/50 - Compression de données génétiques

Abrégé

The present invention relates to a DC/DC converter (1) for transferring an active power between two DC subsystems (5, 6) comprising: —a first converter stage (3) and a second converter stage (4) both configured to be selectively operated as an active inverter or as a passive rectifier; —an AC coupling circuit (2) for coupling the first and the second converter stage (3, 4) by means of an AC power transfer; and —a control unit (10) configured to switch the operation mode of the first and second converter stages (3, 4) depending on a measurement of an amount of power transfer through the AC coupling circuit (2).

Classes IPC  ?

• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation

Abrégé

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Classes IPC  ?

• C25F 3/12 - Attaque de surface des matériaux semi-conducteurs
• B23H 9/14 - Réalisation de trous
• B23H 7/20 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation pour commande de programme, p.ex. commande adaptative
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
• B23H 3/02 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation, commande, prévention des courts-circuits
• C12Q 1/6869 - Méthodes de séquençage
• C25F 7/00 - PROCÉDÉS POUR LE TRAITEMENT D'OBJETS PAR ENLÈVEMENT ÉLECTROLYTIQUE DE MATIÈRE; APPAREILLAGES À CET EFFET Éléments de construction des cellules, ou leur assemblage, pour l'enlèvement électrolytique de matières d'objets; Entretien ou conduite
• G01N 27/447 - Systèmes utilisant l'électrophorèse

Abrégé

de novode novo bottom-up assembly and rational design of allosteric biosensors with programmable input-output behaviors that respond to soluble factors selectively enriched in tumors and trigger co-stimulation and cytokine signals. The disclosed method of effective mechanical coupling and biosensor signaling potency correlates with anti-tumor function. This disclosure provides synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.

Classes IPC  ?

• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance
• C07K 14/725 - Récepteurs de lymphocytes-T
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to methods for the preparation of method of preparation of cDNA library based on one or many RNA samples useful for efficient RNA sequencing and uses thereof. The invention further relates to related tools and kits useful in said method.

Classes IPC  ?

• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p.ex. séquençage par hybridation [SBH]
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

The present relates to a system for automated cell culture, the system comprising an inflow module, a cell culture plate and an outflow module, said inflow module being in fluid connection with the outflow module via the cell culture plate, the inflow module further comprising a microfluidic distribution module in fluid connection with the inflow module, the microfluidic distribution module being configured for controlling the distribution of a fluid flow from the inflow module to the cell culture plate, characterized in that the cell culture plate comprises at least one culture well configured for cell culture, and in that the system further comprises an adaptor coupled to the microfluidic distribution module, the adaptor being reversibly connectable to the cell culture plate so that when the adaptor is connected to the cell culture plate, the distribution of the fluid flow to said culture well is controlled by the microfluidic distribution module.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

The present invention relates to variants of the GAIN domain (G-protein-coupled receptor autoproteolysis-inducing domain) of an adhesion G protein-coupled receptor (ADGRG), such as a GAIN domain variant comprising or consisting of the amino acid sequence of the GAIN domain of ADGRG1 (Adhesion G Protein-Coupled Receptor G1) of SEQ ID NO: 1, wherein (i) one of amino acid positions (3) to (5), preferably amino acid position (4) and one of amino acid positions (47) to (49), preferably amino acid position (48) of SEQ ID NO: 1 are replaced by cysteines, (ii) one of amino acid positions (35) to (37), preferably amino acid position (36) and one of amino acid positions 180 to (182), preferably amino acid position (181) of SEQ ID NO: 1 are replaced by cysteines, (iii) one of amino acid positions (19) to (21), preferably amino acid position 20 and one of amino acid positions (124) to (126), preferably amino acid position (125) of SEQ ID NO: 1 are replaced by cysteines, (iv) one of amino acid positions (56) to (58), preferably amino acid position (57) and one of amino acid positions (65) to (67), preferably amino acid position (66) of SEQ ID NO: 1 are replaced by cysteines, (v) one of amino acid positions (16) to (18), preferably amino acid position (17) and one of amino acid positions (60) to (62), preferably amino acid position (61) of SEQ ID NO: 1 are replaced by cysteines, (vi) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine and the amino acid position at position (181) is replaced by arginine, (vii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine and the amino acid position at position (181) is replaced by arginine, (viii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, and the amino acid position at position (181) is replaced by arginine, (ix) the amino acid position at position (33) is replaced by tryptophane, the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, the amino acid position at position (178) is replaced by tyrosine, the amino acid position at position (181) is replaced by arginine, the amino acid position at position (184) is replaced by glycine, the amino acid position at position (186) is replaced by glutamine, and the amino acid position at position (187) is replaced by glycine, (x) the amino acid position at position (174) is replaced by isoleucine, (xi) the amino acid position at position (218) is replaced by alanine, or (xii) at least two of (i) to (xi) apply; or (B) comprising or consisting of an amino acid sequence sharing at least 80% sequence identity with the variant of (A), provided that the cysteines as defined in (A), item (i), (ii), (iii), (iv) and/or (v), or the amino acid replacement(s) as defined in (A), item (vi), (vii), (viii), (ix), (x) and/or (xi), or the cysteines and/or the amino acid replacement(s) as defined in (A), item (xii) are retained.

Classes IPC  ?

• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype

Abrégé

The invention relates to a nanoplasma switch device, comprising: —multiple electrically isolated electrodes; —a gap separating the two electrodes; wherein the gap has a width which is dimensioned to effect the generation of a plasma by electric-field electron emission.

Classes IPC  ?

• H01J 17/06 - Cathodes
• H01T 4/10 - Limiteurs de surtension utilisant des éclateurs ayant un intervalle simple ou plusieurs intervalles disposés en parallèle

Abrégé

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployable by eversion, said electrode structure (300) comprising: i) an elastic polymeric support (301) operatively connected to the reservoir's inlet (101) through a first end (302) and to the mechanical support (200) at a second end (303), and ii) at least one conductive track (400) disposed on a surface (S) of said elastic polymeric support (301).

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

It is disclosed a method for manufacturing an electrically conductive metal trace (1) comprising depositing metal micro or nano particles (2) in or on a substrate (3); removing an oxide layer (4) around the particles; sintering the particles after oxide layer removal to form the electrically conductive metal trace (1). The method is characterized in that the step of removing the oxide layer is an electrochemical process wherein the metal micro or nano particles are contacted by a reducing agent (5), and the step of sintering is heat sintering induced by light (6). The method is particularly suitable for manufacturing a transient electrically conductive metal trace.

Classes IPC  ?

• H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
• H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur

Abrégé

ncii i = 1,2..., n,pii i = 1,2..., nSASmαjj j = 1,2,..., mL = [Rj,ij,i ]Rj,ij,i αjj pii Sn Vkiki tkk k = 1,2,...,S,V = [Vk,ik,i ]i = 1,2,...,nVkiki cii pii tkk rPk,hk,h tkk k = 1,2,..., sPk,hk,h h= 1,2,...,rPkk htkk D = [dh,ih,i ], DV = [Vk,ik,i ]P = [Pk,hk,h ]dh,ih,i hPk,hk,h iVk,ik,i tkk ΦDBFDBF= [φh,jh,j ], φh,jh,j hαjj Shαjj φh,jh,j ΦDBFDBF.

Classes IPC  ?

• A61B 5/294 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
• A61B 5/311 - Circuits d’entrée à cet effet spécialement adaptés à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least one of the layers, that is not a top layer, constituting an information layer (9i) configured to be modified locally by energy from an electromagnetic beam (7) having a specific beam wavelength and a propagation direction (Z) transverse to the layers. The stacked plurality of layers include an aperiodic layer arrangement including at least three stacked adjacent layers having different thicknesses with respect to each other.

Classes IPC  ?

• G11B 7/24038 - Couches d’enregistrement multiples stratifiées
• G11B 7/24067 - Association de plusieurs couches inter-corrélées de manière spécifique
• G11B 7/242 - Supports d’enregistrement caractérisés par le choix du matériau des couches d'enregistrement

Abrégé

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation (DBS) System for providing Deep Brain Stimulation to brain tissue of a subject (P), - at least one control unit, configured and adapted to provide stimulation data, - at least one stimulation unit (12), operatively connected to the at least one control unit, the at least one stimulation unit (12) being configured and adapted to deliver epidural electrical stimulation (EES) to the dorsal side of the spinal cord (S) of said subject (P), and - at least one implantable pulse generator (IPG) (13), wherein the at least one stimulation unit (12) includes one or more electrodes (14) configured to be implanted epidurally, the one or more electrodes (14) being operatively connected to the at least one IPG (13).

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

The invention relates to oblique transscleral illumination of an eye fundus with at least one physical point light source around the eye allowing for dark field imaging combined with optical coherence tomography imaging

Classes IPC  ?

• A61B 3/12 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p.ex. ophtalmoscopes
• A61B 3/10 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• A61B 3/00 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux
• G06T 7/50 - Récupération de la profondeur ou de la forme

Abrégé

The present invention concerns methods and devices for cultivating coenocytic algae and for producing cellulose, in particular microfibrillated cellulose (MFC). In one embodiment, the algae are grown on a solid substrate immersed in liquid culture medium. The solid substrate preferably comprises a carbonite mineral. The invention also concerns a method for producing spores of said coenocytic algae and a device comprising two separate containers, a first container for growing said algae and a second container for growing larger algae and inducing the generation of spores.

Classes IPC  ?

• A01G 33/00 - Culture des algues
• A01H 4/00 - Reproduction de plantes par des techniques de culture de tissus
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12N 1/12 - Algues unicellulaires; Leurs milieux de culture
• C12P 19/04 - Polysaccharides, c. à d. composés contenant plus de cinq radicaux saccharide reliés entre eux par des liaisons glucosidiques

Abrégé

The present invention concerns a method for determining an estimated value for different parameters on the basis of one or more acquired signals obtained during a Magnetic Resonance Fingerprinting measurement. The method includes using a correction model and/or an iterative approach for improving the accuracy of the obtained estimated values.

Classes IPC  ?

• G01R 33/56 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne
• G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar

Abrégé

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A blood pressure monitor may be implanted without surgery. The blood pressure monitor may transmit real time blood pressure information to a receiver by wireless data transmission.

Classes IPC  ?

• A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

50607070270702707027070270270270237012011011021061231011031061011011010)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

Classes IPC  ?

• C07H 9/04 - Acétals cycliques
• C09K 23/00 - Utilisation de substances comme agents émulsifiants, humidifiants, dispersants ou générateurs de mousse
• C11D 1/66 - Composés non ioniques
• C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide

Abrégé

A device and system for e.g. rehabilitation and assistance of hand motor functions, in particular a portable and under-actuated hand exoskeleton for use in activities of daily living, is disclosed.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée
• A61F 5/01 - Dispositifs orthopédiques, p.ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global neural network model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local training dataset (DS1 to DSn) and a vector of output labels (OL1 to OLn) for training the global model. Further, it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the weights of the global model being encrypted with the collective public key. Each data provider (DP1) computes and aggregates, for each layer of the global model, encrypted local gradients (LG1) using the respective local training dataset (DS1) and output labels (OL1), with forward pass and backpropagation using stochastic gradient descent. At least one data provider homomorphically combines at least a subset of the current local gradients of at least a subset of the data providers into combined local gradients, and updates the weights of the current global model (GM) based on the combined local gradients.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/08 - Répartition de clés

Abrégé

An automated music composition and generation system for automatically harmonizing digital pieces of music using an automated music composition and generation engine for multi-voice music harmonization, including a system-user interface configured to input user parameters comprising at least an instrument designation, a composer style designation, an empty or partial input musical score to be automatically completed, whereby the instrument designation and the composer designation are any one of a predetermined list of instrument designations and composer designations, an automated music composition and generation engine configured to implement a generation strategy that produces playable and well-structured multi-voice music scores, operationally connected to the system-user interface, and a neural network module configured to implement a rhythm recurrent artificial neural network model, a melody recurrent artificial neural network model and a harmony feedforward neural network model that have been trained for combinations of the instrument designations and composer designations of the predetermined list.

Classes IPC  ?

• G10H 1/00 - INSTRUMENTS DE MUSIQUE ÉLECTROPHONIQUES; INSTRUMENTS DANS LESQUELS LES SONS SONT PRODUITS PAR DES MOYENS ÉLECTROMÉCANIQUES OU DES GÉNÉRATEURS ÉLECTRONIQUES, OU DANS LESQUELS LES SONS SONT SYNTHÉTISÉS À PARTIR D'UNE MÉMOIRE DE DONNÉES Éléments d'instruments de musique électrophoniques

Abrégé

The present invention provides a method for preparing a sequencing library from a ribonucleic acid (RNA) sample.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

A device for fragmenting ions by collision induced dissociation, the device intended to be used together with a planar ion mobility apparatus, the device including a first conductive grid having a plurality of first openings, the first conductive grid configured for electric interconnection to a first electric potential, and a second conductive grid having a plurality of second openings, the second conductive grid configured for electric interconnection to a second electric potential, the first and second conductive grids being electrically insulated from each other.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• G01N 27/622 - Spectrométrie de mobilité ionique
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules - Détails

Abrégé

in silicode novo in silico in silico in silico based on the peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) of (e) an ensemble of peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) for which the lowest interface energy peptide-protein molecular complexes can be modelled, thereby obtaining engineered peptides and/or proteins being capable of forming a molecular complex with engineered binding characteristics.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire

Abrégé

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

Classes IPC  ?

• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

The present invention concerns a waveguide amplifier comprising: - at least one embedding cladding material or layer, and - at least one rare-earth ion implanted silicon nitride material or layer embedded in the at least one embedding cladding material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core enclosed by the at least one embedding cladding material or layer.

Classes IPC  ?

• H01S 3/063 - Lasers à guide d'ondes, p.ex. amplificateurs laser
• H01S 3/16 - Matériaux solides
• H01S 5/40 - Agencement de plusieurs lasers à semi-conducteurs, non prévu dans les groupes
• H01S 3/0941 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p.ex. par une diode laser
• H01S 3/094 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente

Abrégé

In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph includes identifying a directed functional edge of the functional subgraph based on presence of structural connection and directional communication of information across the same structural connection.

Classes IPC  ?

• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage
• G06N 7/01 - Modèles graphiques probabilistes, p.ex. réseaux probabilistes

Abrégé

A method for operating a light microscope comprises emitting and guiding a plurality of illumination light beams towards a specimen (6) to form a plurality of separated illumination light spots (2A, 2B, 2C, 2D) at the specimen; and guiding detection light beams (11) coming from the illumination light spots (2A, 2B, 2C, 2D) to a detector (10) comprising a plurality of sensor arrays (31-34). Each sensor array (31-34) comprises photon-counting detector elements (40), and detection light beams (11) from different illumination light spots (2A, 2B, 2C, 2D) are guided to different sensor arrays (31-34). Measured signals from the sensor arrays (31-34) are analysed to determine positional information about the light spots (15) on the sensor arrays (31 -34). It is adjusted where the light spots (15) hit the sensor arrays (31-34) based on the positional information. A corresponding light microscope is furthermore disclosed.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G01J 1/44 - Circuits électriques
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

M. smithiiM. smithiiM. smithiiM. smithii M. smithii M. smithii for promoting immune system homeostasis and intestinal health and for treating disorders associated with aberrant microbiota and/or archaea-deficiency.

Classes IPC  ?

• A61K 35/741 - Probiotiques
• C07K 16/12 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• G01N 33/577 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des anticorps monoclonaux

Abrégé

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

Classes IPC  ?

• C08J 3/075 - Gels macromoléculaires
• A61K 9/06 - Onguents; Excipients pour ceux-ci
• A61K 9/50 - Microcapsules

Abrégé

CNG power system (1) comprising a storage tank (6) connected fluidically to a fuel conversion system (2) via an energy transfer system (4), the fuel conversion system (2) comprising a power unit using CNG as fuel and generating gas emissions comprising CO2, the fuel conversion system comprising a CO2 capture unit (16) configured for separating out CO2 from the gas emissions. The energy transfer system comprises a CNG expansion turbine (22) mounted in a fuel circuit (8) between the storage tank and fuel conversion system powered by expansion of the CNG flowing from the storage tank to the fuel conversion system, and a CO2 compressor (24) connected between the fuel conversion system and the storage tank along a CO2 circuit (10) for compressing the CO2, power for driving the CO2 compressor (24) being supplied in part by power generated by the CNG expansion turbine (22).

Classes IPC  ?

• F17C 13/00 - RÉCIPIENTS POUR CONTENIR OU EMMAGASINER DES GAZ COMPRIMÉS, LIQUÉFIÉS OU SOLIDIFIÉS; GAZOMÈTRES À CAPACITÉ FIXE; REMPLISSAGE OU VIDAGE DE RÉCIPIENTS DE GAZ COMPRIMÉS, LIQUÉFIÉS OU SOLIDIFIÉS - Détails des récipients ou bien du remplissage ou du vidage des récipients

Abrégé

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

Classes IPC  ?

• A61K 35/14 - Sang; Sang artificiel
• A61K 38/45 - Transférases (2)
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/09 - Cellules tumorales

Abrégé

A haptic device is disclosed comprising at least one fluidic actuator operatively connectable with pumping means; and a plurality of movable members mechanically connected with said at least one fluidic actuator, wherein said movable members can perform a displacement upon actuation of the fluidic actuator and/or resist the movements of a body part of a user upon actuation of the fluidic actuator, to provide a tactile and/or force haptic sensation to a body part of a user. Methods for providing a haptic sensation to a user and receiving haptic input commands from a user are also disclosed.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• A61H 39/00 - Dispositifs de physiothérapie pour localiser ou stimuler les endroits spécifiques de réflexe du corps, p.ex. acupuncture
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/304 - Circuits de commutation

Abrégé

A method for labelling a portion of a device includes the steps of providing a first substrate layer of a transparent or translucent material, depositing a first coloured material onto the first substrate layer in a labelling portion of the layer, thereby obtaining a labelling item, and coupling the labelling item to the device. The method is particularly suitable for producing labelled stretchable devices such as soft body-implantable devices for sensing a physiological signal and/or stimulating an electrical and/or pharmacological activity of a body tissue or organ in a subject.

Classes IPC  ?

• A61B 90/92 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des codes de couleurs

Abrégé

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for dimensionality reduction of time-series using contrastive learning. A method can include receiving multidimensional input time series data that includes data from a session or sessions that span time, selecting positive samples and negative samples from the multidimensional input time series data for respective reference samples from the multidimensional input time series data, wherein the positive samples and negative samples are each selected with a respective predetermined distribution across the time of the session or sessions of the multidimensional input time series, and mapping the reference samples, the positive samples, and negative samples into a common embedding space.

Classes IPC  ?

• G06N 3/0895 - Apprentissage faiblement supervisé, p.ex. apprentissage semi-supervisé ou auto-supervisé
• G06N 3/045 - Combinaisons de réseaux
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or bacterial infections or coinfection by virus and bacteria.

Classes IPC  ?

• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07D 405/00 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle
• C07D 409/00 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle

Abrégé

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61P 35/00 - Agents anticancéreux
• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present disclosure relates to a method for generating variants of a protein based on a native protein regulated by allosteric pathway, the method comprising: i) providing 3D structures of the native protein; ii) identifying at least one pair of coupled allosteric sites within the amino acid sequence of the native protein named microswitch; iii) generating in silico mutations of said identified microswitch to generate a pool of variants; iv) computing at least one score reflecting the variation in allosteric coupling; and/or the variation in the relative stability v) predicting the activity of each variant compared to the native protein based on the computed score. The disclosure also concern a computer implemented program to carry out said method, and a variant of a protein or an active fragment thereof, a polynucleotide.

Classes IPC  ?

• C07K 14/72 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des hormones
• G16B 15/20 - Repliement de protéines ou de domaines
• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
• G16B 20/50 - Mutagénèse

Abrégé

A dielectrophoretic detection device including a chip, with a flow channel having at least one inlet and one outlet, and at least a detection area configured to detect analytes trapped on functionalised beads flowing within the flow channel, first and second electrode assemblies shaped as rows of parallel pillars extending a the height of the flow channel, and configured to generate under electric tension an electric field to form an electrical barrier, and preventing the beads to cross the barrier and drawing the beads to the detection area by dielectrophoretic forces where they are clustered and concentrated. The device may be provided with multiple rows of parallel pillars of electrode assemblies extending over the height of the flow channel, forming multiple concentration lines. The flow channel may be provided with further rows of parallel pillars of electrode assemblies crossing the flow channel in a transverse direction, forming further incubation lines.

Classes IPC  ?

• B03C 5/00 - Séparation de particules des liquides dans lesquels elles sont dispersées, par effet électrostatique
• G01N 1/40 - Concentration des échantillons
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B03C 5/02 - Séparateurs

Abrégé

A force-feedback surface that creates and modulates distinctive profile and stiffnessto interact with a user in contact thereto, the surface being functionally independentto be used as a single module but can be customized to extend the application indiverse fields by assembling in series, parallel, or any combinations to form amultimodular system.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée

Abrégé

Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.

Classes IPC  ?

• H04L 25/08 - Modifications pour réduire les perturbations; Modifications pour réduire les effets des défauts de ligne
• H04B 10/54 - Modulation d'intensité
• H04B 7/0413 - Systèmes MIMO
• H04L 25/02 - Systèmes à bande de base - Détails
• H04L 25/49 - Circuits d'émission; Circuits de réception à au moins trois niveaux d'amplitude
• H04L 5/00 - Dispositions destinées à permettre l'usage multiple de la voie de transmission

Abrégé

A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a G protein or an arrestin protein in a cell.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

A computer-implemented inverse rendering method comprising: computing an adjoint image by differentiating an objective function that evaluates the quality of a rendered image, image elements of the adjoint image encoding the sensitivity of spatially corresponding image elements of the rendered image with respect to the objective function; sampling the adjoint image at a respective sample position to determine a respective adjoint radiance value associated with the respective sample position; emitting the respective adjoint radiance value into a scene model characterised by scene parameters; determining an interaction location of a respective incident adjoint radiance value with a surface and/or volume of the scene model; determining a respective incident radiance value or an approximation thereof at the interaction location; and updating a scene parameter gradient.

Classes IPC  ?

• G06T 15/00 - Rendu d'images tridimensionnelles [3D]
• G06T 7/00 - Analyse d'image
• G06T 15/06 - Lancer de rayon
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06T 15/50 - Effets de lumière

Abrégé

A method for producing a carbonate-containing species-rich, nitrogen-containing species-free solution from a urea-rich solution is proposed. The method comprising the steps of: providing a first reservoir comprising a first mixture including urea and a catalyser comprising an enzymatic catalyser and/or a microorganism; allowing an enzymatic reaction catalysed by the catalyser to decompose urea, thereby obtaining a second mixture comprising nitrogen-containing species and carbonate-containing species; converting at least some of the nitrogen-containing species into gaseous nitrogen-containing species to obtain a third mixture comprising the gaseous nitrogen-containing species and the carbonate-containing species; filtering the third mixture by a gas- permeable filter, thereby separating at least some of the gaseous nitrogen-containing species from the carbonate-containing species while keeping the catalyser away from the gas-permeable filter; and collecting the so-obtained carbonate-containing species-rich, nitrogen-containing species-free solution.

Classes IPC  ?

• C09K 17/10 - Ciments, p.ex. ciment Portland
• C04B 12/00 - Ciments non prévus par les groupes  
• C12M 1/04 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques
• E02D 3/12 - Consolidation par mise en place dans le sol de produits solidifiants ou obturant les pores

Abrégé

The present invention concerns a method for producing at least one ferroelectric device or structure comprising the steps of providing at least one ferroelectric material or layer, or providing at least one ferroelectric material or layer to be patterned or structured; depositing at least one adhesion layer on a first side of the at least one ferroelectric material or layer; and depositing at least one diamond-like carbon layer or material on the at least one adhesion layer.

Classes IPC  ?

• G02F 1/00 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire
• G02B 6/136 - Circuits optiques intégrés caractérisés par le procédé de fabrication par gravure
• G02F 1/05 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr avec des propriétés ferro-électriques

Abrégé

1233)+n1233 are independently selected from a hydrocarbyl group containing 1-40 carbon atoms said hydrocarbyl group, if said hydrocarbyl group comprises 3 or more carbons, may be linear or branched; and W is an anion.

Classes IPC  ?

• H01L 51/42 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement en énergie électrique, soit comme dispositifs de commande de l'énergie électrique par ledit rayonnement

Abrégé

ssTRTRR).

Classes IPC  ?

• G01S 7/288 - Récepteurs cohérents
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• G01S 13/28 - Systèmes pour mesurer la distance uniquement utilisant la transmission de trains discontinus d'ondes modulées par impulsions dans lesquels les impulsions émises utilisent une onde porteuse modulée en fréquence ou en phase avec compression dans le temps des impulsions reçues
• G01S 17/36 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées avec comparaison en phase entre le signal reçu et le signal transmis au même moment
• G01S 17/86 - Combinaisons de systèmes lidar avec des systèmes autres que lidar, radar ou sonar, p.ex. avec des goniomètres

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local model (LM1 to LMn) and a respective local training dataset (DS1 to DSn) for training the local model using an iterative training algorithm (IA). Further it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the local and global model being encrypted with the collective public key. Each data provider (DP1) trains its local model (LM1) using the respective local training dataset (DS1) by executing gradient descent updates of its local model (LM1), and combining (1340) the updated local model (LM1′) with the current global model (GM) into a current local model (LM1c). At least one data provider homomorphically combines at least a subset of the current local models of at least a subset of the data providers into a combined model (CM1), and updates the current global model (GM) based on the combined model. The updated global model is provided to at least a subset of the other data providers.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• G06N 3/098 - Apprentissage distribué, p.ex. apprentissage fédéré

Abrégé

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.

Classes IPC  ?

• A61L 27/20 - Polysaccharides
• A61F 2/00 - Filtres implantables dans les vaisseaux sanguins; Prothèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corps; Appareils pour les assujettir au corps; Dispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p.ex. stents
• A61F 2/12 - Prothèses mammaires
• A61L 27/16 - Matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/24 - Collagène
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p.ex. substances thérapeutiques
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
• A61L 24/00 - Adhésifs ou ciments chirurgicaux; Adhésifs pour dispositifs de colostomie
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels

Abrégé

Electronic metadevice comprising a conductive channel; a metal layer superposed on the conductive channel; and a barrier layer located between the metal layer and the conductive channel. The metal layer includes at least one recess extending through the metal layer to define at least one metallic metastructure comprising at least one first metal layer portion adjacent to at least one second metal layer portion. The recess extends through the metal layer to define a micro-structured or a nano-structured first metal layer portion comprising at least one first metallic extension or finger extending away from a first support of the first metal layer portion towards the second metal layer portion; and a micro-structured or a nano-structured at least one second metal layer portion comprising at least one second metallic extension or finger extending away from a second support of the second metal layer portion towards the first metal layer portion.

Classes IPC  ?

• H01L 29/86 - Types de dispositifs semi-conducteurs commandés uniquement par la variation du courant électrique fourni, ou uniquement par la tension électrique appliquée, à l'une ou plusieurs des électrodes transportant le courant à redresser, amplifier, faire osciller, ou commuter
• H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
• H01L 29/417 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative transportant le courant à redresser, à amplifier ou à commuter
• H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
• H01L 29/24 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des matériaux semi-conducteurs inorganiques non couverts par les groupes , ,  ou

Abrégé

A micro- or nanostructured optical element (1) is proposed comprising: a membrane (3) with an array of holes (5), the membrane (3) comprising a membrane light wave facing surface; an array of pillars (7) sized and shaped such that a respective pillar (7) is configured to be at least partially received in a respective hole (5), the respective pillar (7) defining a central pillar axis, and comprising a pillar light wave facing surface; a support (9) configured to support the pillars (7); and an actuation mechanism configured to selectively generate a relative displacement between the membrane (3) and the pillars (7) along the central pillar axes to thereby define a first optical element reflectance state, where the membrane (3) is in an elevated position with respect to the support (9), and a second, different optical element reflectance state, where the membrane (3) is in a lowered position with respect to the support (9) such that the respective pillar (7) extends through the respective hole (5). In the first optical element reflectance state, the membrane light wave facing surface is substantially flush with the pillar light wave facing surfaces, or the membrane light wave facing surface is placed beyond the pillar light wave facing surfaces.

Classes IPC  ?

• G02B 26/00 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables

Abrégé

A hollow variable stiffness thread including a flexible inner tube, a conductive shape memory polymer (CSMP) layer arranged around the inner tube forming a variable stiffness zone, a flexible encapsulation layer arranged around the CSMP layer, and a first electrode and a second electrode, at least a portion of the first and the second electrodes being in contact with the CSMP layer.

Classes IPC  ?

• A61B 18/14 - Sondes ou électrodes à cet effet
• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/00 - Cathéters; Sondes creuses
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets

Abrégé

Compounds, compositions and methods that can be used for the treatment of viral diseases are provided.

Classes IPC  ?

• A61P 31/12 - Antiviraux
• C07K 16/08 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61P 37/02 - Immunomodulateurs
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

A smart wearable (SW) for collecting data on an integrity of a joint of a wearer, the wearable including a first frame (1) configured to be attached in proximity of the joint of the wearer, the frame (1) including an elastic sensor frame (3) having an open cavity (21) configured to be attached to an area of interest of the joint, a kinematic sensor device (19) configured to measure kinematics of the joint, and acoustic sensor device (13) arranged in the cavity (21) configured to capture airborne acoustic emissions from the area of interest, and a data processor device (18) configured to receive and record data from the kinematic sensor device (19) and from the acoustic sensor device (13).

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

A method for enforcing smoothness constraints on surface meshes produced by a Graph Convolutional Neural Network (GCNN) including the steps of reading image data from a memory, the image data including two-dimensional image data representing a three-dimensional object or a three-dimensional image stack of the three-dimensional object, performing a GCNN mesh deformation step on the image data to obtain an approximation of a surface of the three-dimensional object, the surface represented by triangulated surface meshes, at least some vertices of the triangulated surface meshes having a different number of neighboring vertices compared to other vertices in a same triangulated surface mesh, and performing a deep active surface model (DASM) transformation step on the triangulated surface meshes to obtain a corrected representation of the surface of three-dimensional object to improve smoothness of the surface.

Classes IPC  ?

• G06T 17/20 - Description filaire, p.ex. polygonalisation ou tessellation
• G06K 9/62 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques
• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion

Abrégé

The disclosure relates to dendritic polyglycerols (dPG) compounds with carboxyalkyl, sulfyl or sulfonyl functional groups that irreversibly inhibit viral infection (virucidal effect) through multivalent interaction in nanomolar concentration range. While the compounds of the disclosure show virus inhibition in the nanomolar range they show no in-vitro toxicity in the same range of concentration.

Classes IPC  ?

• A61K 31/765 - Polymères contenant de l'oxygène
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A01N 31/02 - Composés acycliques
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61K 31/795 - Polymères contenant du soufre
• A01N 41/04 - Acides sulfoniques; Leurs dérivés
• C08G 65/48 - Polymères modifiés par post-traitement chimique

Abrégé

A photonic assembly, a laser setup comprising said photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using said laser setup are disclosed. The photonic assembly (1) comprises an active photonic chip (10), a photonic modulator chip (2) comprising a photonic circuit arrangement, and a tuning arrangement comprising a modulation element (33) having a thickness of 10 micrometers or less. The active photonic chip (10) and the photonic modulator chip (2) are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip (10). The modulation element (33) is arranged such, that an actuation of the modulation element (33) tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

Classes IPC  ?

• H01S 3/107 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p.ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs électro-optiques, p.ex. produisant un effet Pockels ou Kerr
• G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
• H01S 3/11 - Blocage de modes; Commutation-Q; Autres techniques d'impulsions géantes, p.ex. vidange de cavité
• H01S 5/14 - Lasers à cavité externe

Abrégé

The present invention is related to a stretchable tubular device (1) comprising at least one layer (Lx) of a stretchable polymer, a power supply (2) and a set of electrodes (3a, 3b) connected to said power supply (2). The power supply can supply at least a first level of voltage (V1) to the electrodes so as to modify the natural force (F0) of the stretchable layers to a modified force (F1). The present invention also covers a process for manufacturing such a tubular device and its use as a medical implant.

Classes IPC  ?

• A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p.ex. dispositifs permanents d’assistance cardiaque endovasculaire
• A61M 60/486 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails concernant l’entraînement pour des dispositifs d’actionnement circulatoire mécanique la force agissant sur les moyens d’actionnement étant mécanique, p.ex. éléments à entraînement mécanique de pincement d’un vaisseau sanguin générée par des organes d’actionnement électro-actifs, p.ex. en utilisant des polymères électro-actifs ou des éléments piézoélectriques
• A61M 60/531 - Régulation par des données du patient en temps réel par des données de tension artérielle, p.ex. provenant de capteurs de tension

Abrégé

Disclosed herein is a method of operating a microfluidic system, a microfluidic system for manipulating sample objects, and a control system for operating a microfluidic system. The method according to the invention is for operating a microfluidic system that comprises a manipulation zone for manipulating sample objects flowing through the manipulation zone, a first detection zone arranged upstream of or in the manipulation zone and a second detection zone arranged upstream of, in or downstream of the manipulation zone. A first count is determined that characterizes a number of sample objects flowing through the first detection zone. Sample objects are manipulated in the manipulation zone. A second count is determined that characterizes a number of sample objects flowing through the second detection zone. One or more manipulation parameters for manipulating the sample objects in the manipulation zone are adjusted based on the first count and the second count.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 15/14 - Recherche par des moyens électro-optiques
• G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p.ex. analyse à injection dans un écoulement
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

The invention concerns a single-particle inductively-coupled plasma (ICP) mass spectrometry particle sizing and counting method comprising providing or receiving an intensity-versus-counts histogram of particles detected using an ICP mass spectrometer, the intensity representing particle detection and the count representing particle detection frequency; providing or receiving mass flux calibration data or calibration curve data relating a value of the intensity measurement or data of the ICP mass spectrometer to a mass of material detected per acquisition interval or dwell time; determining a particle mass of the particles detected using the mass flux calibration data or the at least one mass flux calibration curve data, determining a particle volume of the detected particles using the determined particle mass, and determining a particle size of the particles detected using the determined particle volume of the particles detected and a determined or attributed geometry or shape of the detected particles.

Classes IPC  ?

• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G01N 15/10 - Recherche de particules individuelles
• G01N 15/00 - Recherche de caractéristiques de particules; Recherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/10 - Sources d'ions; Canons à ions

Abrégé

The invention relates to a photoplethysmography (PPG) sensing device comprising—a pulsed light source, —at least one pixel to create photo-generated electrons, synchronized with said pulsed light source. It is mainly characterized in that each pixel comprises: —a pinned photodiode (PPD) having two electronic connection nodes, —a sense node (SN), to convert the photo-generated electrons into a voltage, and—a Transfer Gate (TGtransfer) transistor, having its source electronically connected to one electronic connection node of said pinned photodiode (PPD), and being configured to act as a transfer gate (TG) between said pinned photodiode (PPD) and said sense node (SN), allowing the photo-generated electrons to sink when the light is pulsed-off, the photo-generated electrons integration when the light is pulsed-on and the transfer of at least part of the integrated photo-generated electrons to said sense node for a read-out.

Classes IPC  ?

• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• H01L 27/14 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des composants semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit ra
• H04N 25/00 - Circuits de capteurs d'images à l'état solide [capteurs SSIS]; Leur commande