Colorado State University Research Foundation

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IPC Class
A61F 2/24 - Heart valves 2
A61P 35/00 - Antineoplastic agents 2
C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like 2
C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity 2
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules 2
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Registered / In Force 10
Found results for  patents

1.

PLUME IDENTIFICATION ALGORITHM FOR OPTICAL NATURAL GAS EMISSIONS IMAGING

      
Document Number 03218624
Status Pending
Filing Date 2022-10-06
Open to Public Date 2023-04-13
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Zimmerle, Daniel
  • Martinez, Marcus

Abstract

A method may include receiving video data that includes frames representative of infrared radiation within a scene. Each of the frames may include pixels The method may also include identifying pixels within the frames that correspond to a gas plume released by a gas source within the scene based on the infrared radiation. In addition, the method may include determining a size of the gas plume within each frame based on the identified pixels.

IPC Classes  ?

  • G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis

2.

AIR SOURCE HEAT PUMP SYSTEM AND METHOD OF USE FOR INDUSTRIAL STEAM GENERATION

      
Document Number 03221677
Status Pending
Filing Date 2022-06-14
Open to Public Date 2022-12-22
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • ATMOSZERO, INC. (USA)
Inventor
  • Bandhauer, Todd M.
  • Salvi, Ashwin
  • Stark, Addison
  • Roberts, Nickolas

Abstract

A system for generating steam for industrial heat. The system may include a plurality of heat pump cycles in thermal communication with each other and in thermal communication with a steam generation cycle. The plurality of heat pump cycles may include first and second heat pump cycles. The first heat pump circulates a first a working fluid and includes a first heat exchanger. The second heat pump cycle circulates a second working fluid and includes a second heat exchanger. The first heat exchanger transfers heat from the first to the second working fluid. The second heat exchanger transfers heat to a third working fluid in the steam generation cycle.

IPC Classes  ?

  • F22B 1/00 - Methods of steam generation characterised by form of heating method
  • F25B 7/00 - Compression machines, plants or systems, with cascade operation, i.e. with two or more circuits, the heat from the condenser of one circuit being absorbed by the evaporator of the next circuit
  • F25B 9/00 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
  • F25B 11/04 - Compression machines, plants or systems, using turbines, e.g. gas turbines as expanders centrifugal type
  • F25B 25/02 - Compression-sorption machines, plants, or systems
  • F25B 27/00 - Machines, plants or systems, using particular sources of energy
  • F25B 30/02 - Heat pumps of the compression type
  • F25B 31/02 - Compressor arrangements of motor-compressor units

3.

SYNTHESIS AND CHARACTERIZATION OF VANADIUM COMPLEXES

      
Document Number 03161237
Status Pending
Filing Date 2022-06-01
Open to Public Date 2022-12-01
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Crans, Debbie C.
  • Murakami, Heide
  • Kostenkova, Kateryna

Abstract

The present application relates to preparation methods and uses of vanadium complexes providing a consistent and stable preparation. More specifically, the present application relates to preparation of vanadium citrate salts, phosphate salts, or combinations thereof, characterization of the properties of such salts, and methods using the same.

IPC Classes  ?

  • A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
  • A61K 33/24 - Heavy metals; Compounds thereof
  • A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
  • A61P 35/00 - Antineoplastic agents
  • A61P 37/02 - Immunomodulators
  • B01J 31/36 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of vanadium, niobium or tantalum
  • H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

4.

MULTILAYER COATING SYSTEMS OBTAINED FROM BLOCK COPOLYMER CONTAINING BASECOAT COMPOSITIONS

      
Document Number 03211750
Status Pending
Filing Date 2022-03-18
Open to Public Date 2022-09-22
Owner
  • BASF COATINGS GMBH (Germany)
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • CYPRIS MATERIALS (USA)
Inventor
  • Bokhart, Rosalva Castrejon
  • Zhang, Qingling
  • Campbell, Donald H.
  • Ferris, Daniel Patrick
  • Miyake, Garret
  • Pearson, Ryan
  • Ryan, Matthew
  • Whitson, Luke
  • Hess, Alexander

Abstract

The present invention relates to a multilayer coating system present on a substrate and comprising at least three coating layers (L1, L2 and L3) being different from one another, namely a first pigmented coating layer (L1) applied over at least a portion of the substrate, a second coating layer (L2) applied over the first pigmented coating layer (L1), and a third coating layer (L3) applied over the second coating layer (L2), wherein the second coating layer (L2) is formed from a coating composition comprising at least one block copolymer containing a backbone and at least two blocks (B1 and B2) and side chains (S1 and S2) comprising different polymeric moieties (M1 and M2), a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a use of a coating composition comprising the block copolymer for improving, in particular for increasing, the chromaticity of the inventive multilayer coating system.

IPC Classes  ?

  • C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

5.

MULTILAYER COATING SYSTEMS OBTAINED FROM BLOCK COPOLYMER CONTAINING TOPCOAT COMPOSITIONS

      
Document Number 03211760
Status Pending
Filing Date 2022-03-18
Open to Public Date 2022-09-22
Owner
  • BASF COATINGS GMBH (Germany)
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • CYPRIS MATERIALS (USA)
Inventor
  • Bokhart, Rosalva Castrejon
  • Zhang, Qingling
  • Campbell, Donald H.
  • Ferris, Daniel Patrick
  • Miyake, Garret
  • Pearson, Ryan
  • Ryan, Matthew
  • Whitson, Luke
  • Hess, Alexander

Abstract

The present invention relates to a multilayer coating system present on a substrate and comprising at least two coating layers L1 and L2 being different from one another, namely a first coating layer L1 applied over at least a portion of the substrate, and a second topcoat layer L2 applied over the first coating layer L1, wherein the topcoat layer L2 is formed from a coating composition comprising at least one block copolymer containing a backbone and at least two blocks B1 and B2 and side chains S1 and S2 comprising different polymeric moieties M1 and M2, a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a use of a coating composition comprising the block copolymer for improving, in particular for increasing, the chromaticity of the inventive multilayer coating system.

IPC Classes  ?

  • B05D 1/38 - Successively applying liquids or other fluent materials, e.g. without intermediate treatment with intermediate treatment
  • B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
  • B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
  • C09D 167/06 - Unsaturated polyesters having carbon-to-carbon unsaturation
  • C09D 201/08 - Carboxyl groups

6.

SYNTHESIS OF STRUCTURAL ANALOGS OF LARGAZOLE AND ASSOCIATED COMPOUNDS

      
Document Number 03205814
Status Pending
Filing Date 2021-12-16
Open to Public Date 2022-06-30
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • CETYA THERAPEUTICS, INC. (USA)
Inventor
  • Williams, Robert M.
  • Koti, Sivanagireddy
  • De, Subhadip
  • Shelke, Anil M.
  • Cerbone, Ryan E.
  • Yasuda, Nobuyoshi

Abstract

Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety. Also disclosed are various intermediate compounds obtained when preparing structural analogs of largazole and derivatives thereof, including macrocycle analogs having an alcohol functionality.

IPC Classes  ?

  • C07D 513/18 - Bridged systems
  • A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
  • A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61P 35/00 - Antineoplastic agents

7.

PROTEASE INHIBITORS AND THEIR USE TO PROVIDE DISEASE RESISTANCE IN PLANTS AND AS ANTIMICROBIALS

      
Document Number 03201211
Status Pending
Filing Date 2021-12-10
Open to Public Date 2022-06-16
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Heuberger, Adam L.
  • Charkowski, Amy O.
  • Joshi, Janak R.

Abstract

Compositions and methods for enhancing the resistance of plants to a disease caused by a bacterial pathogen are provided. The compositions comprise nucleic acid molecules encoding protease inhibitor gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to a disease caused by a bacterial pathogen comprise introducing a nucleic acid molecule encoding a protease inhibitor gene product into a plant cell. Additionally provided are antimicrobial compositions containing one or more protease inhibitor proteins for controlling antimicrobial growth on plants or plant parts, and methods for controlling or preventing the growth of microbial pathogens, and in particular bacterial pathogens, on plants and plant parts.

IPC Classes  ?

  • A01H 1/00 - Processes for modifying genotypes
  • C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

8.

CYP81E GENES CONFERRING HERBICIDE TOLERANCE

      
Document Number 03189906
Status Pending
Filing Date 2021-09-01
Open to Public Date 2022-03-10
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (USA)
  • MONSANTO TECHNOLOGY LLC (USA)
Inventor
  • Gaines, Todd
  • Rodrigues Alves De Figueiredo, Marcelo
  • Tranel, Patrick John
  • Giacomini, Darci Ann
  • Beffa, Roland

Abstract

The present disclosure relates to a plant or plant part comprising a polynucleotide encoding a CYP81E polypeptide, the expression of the polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The disclosure further provides kits for identifying herbicide resistant plants and methods for determining whether a plant is herbicide resistant.

IPC Classes  ?

  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

9.

CAPILLARY-DRIVEN COLORIMETRIC ASSAY DEVICES

      
Document Number 03185873
Status Pending
Filing Date 2021-07-29
Open to Public Date 2022-02-03
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Henry, Charles S.
  • Geiss, Brian J.
  • Dandy, David S.
  • Carrell, Cody
  • Link, Jeremy
  • Samper, Isabelle
  • Sanchez-Cano, Ana
  • Jang, Ilhoon
  • Call, Zachary

Abstract

An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay.

IPC Classes  ?

  • G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

10.

ELECTRODEPOSITION OF PURE PHASE SNSB FROM EUTECTIC ETHALINE SOLUTION FOR SODIUM-ION AND LITHIUM-ION BATTERY ANODES

      
Document Number 03176916
Status Pending
Filing Date 2021-05-11
Open to Public Date 2021-11-18
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Ma, Jeffrey
  • Prieto, Amy L.

Abstract

Electrodeposition of pure phase SnSb from equimolar quantities of Sn(II) and Sb(III) chlorides in an eutectic ethaline solution on a conducting metal substrate, for use as a sodium-ion battery anode or a lithium ion battery anode, without the need for binders, carbon additives, or post-processing is described.

IPC Classes  ?

  • H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
  • H01M 4/52 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron

11.

PHOTO REACTOR DEVICES, SYSTEMS, AND METHODS OF USE THEREOF

      
Document Number 03172431
Status Pending
Filing Date 2021-03-24
Open to Public Date 2021-09-30
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Willson, Bryan D.
  • Goodrich, Raymond P.
  • Mizia, John C.
  • Willman, Matthew R.

Abstract

A device for emitting photons into a fluid is disclosed. The device includes a fluid channel configured to transfer the fluid from an inlet to an outlet thereof and the fluid channel having a helical pathway wound about a longitudinal axis. The device also includes at least one inner light source adjacent the fluid channel, the at least one inner light source positioned between the fluid channel and the longitudinal axis and at least one outer light source adjacent the fluid channel, the fluid channel positioned between the outer light source and the longitudinal axis.

IPC Classes  ?

  • A61L 2/10 - Ultraviolet radiation
  • C12N 7/04 - Inactivation or attenuation; Producing viral sub-units

12.

PRODUCTION OF VACCINES COMPRISING INACTIVATED SARS-COV-2 VIRAL PARTICLES

      
Document Number 03170563
Status Pending
Filing Date 2021-03-05
Open to Public Date 2021-09-10
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • DYNAVAX TECHNOLOGIES CORPORATION (USA)
Inventor
  • Goodrich, Raymond P.
  • Bowen, Richard

Abstract

Provided herein are methods for inactivating a viral particle, the methods comprising contacting the viral particle with UV light in the presence of riboflavin. In some embodiments, the viral particle is a SARS-CoV-2 particle. Vaccine compositions comprising inactivated viral particles (e.g., inactivated SARS-CoV-2 particles) are also provided. In some embodiments, the vaccine compositions comprise an adjuvant capable of promoting a Th1-type immune response.

IPC Classes  ?

  • A61K 39/12 - Viral antigens
  • A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
  • A61P 31/14 - Antivirals for RNA viruses
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

13.

METHODS AND APPARATUS FOR EFFICIENTLY RENDERING, MANAGING, RECORDING, AND REPLAYING INTERACTIVE, MULTIUSER, VIRTUAL REALITY EXPERIENCES

      
Document Number 03105067
Status Pending
Filing Date 2019-06-27
Open to Public Date 2020-01-02
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Clapp, Tod Robert
  • Garbe, Brendan
  • Eitel, Chad

Abstract

In some embodiments, an apparatus includes a volatile memory, a non-volatile memory, a first processor coupled to the non-volatile memory and configured to receive a data set associated with an object and user information associated with a spatial position of a user in a multi-user virtual (IMVR) environment, and a second processor coupled to the volatile memory, the second processor configured to render an instance of the portion of the object in the IMVR environment from a perspective of the user based on the spatial position of the user. The first processor is configured to generate a look-up table (LUT) based on a set of inputs received from a user. The second processor is configured to render, based on the LUT and information related to a manipulation by a user, an updated instance of the portion of the object that manifests an effect of the manipulation in the IMVR environment.

IPC Classes  ?

  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
  • G06T 15/08 - Volume rendering
  • G06T 19/00 - Manipulating 3D models or images for computer graphics
  • G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
  • G16H 30/00 - ICT specially adapted for the handling or processing of medical images

14.

CANCER VACCINE COMPOSITIONS AND METHODS OF USE THEREOF

      
Document Number 03093723
Status Pending
Filing Date 2019-03-21
Open to Public Date 2019-09-26
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Opgenorth, Terry
  • Guth, Amanda
  • Goodrich, Raymond

Abstract

The disclosure provides a cancer vaccine composition comprising inactivated cancer cells and an adjuvant, wherein the inactivated cancer cells are incapable of replication. Also provided is a method for producing a cancer vaccine composition, the method comprising contacting cancer cells with light (e.g., UV light) in the presence of a photosensitizer (e.g., riboflavin).

IPC Classes  ?

  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

15.

BETA-ALETHINE, IMMUNE MODULATORS, AND USES THEREOF

      
Document Number 03042698
Status Pending
Filing Date 2017-11-03
Open to Public Date 2018-05-11
Owner
  • AXIMMUNE, INC. (USA)
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Taub, Floyd
  • Guth, Amanda

Abstract

The present disclosure provides methods, kits, and compositions comprising -alethine and one or more immune modulators and methods to determine when they are advantageous. Particular applications include the use of -alethine and one or more immune modulators in the treatment of cancer.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans

16.

COMPOSITIONS AND METHODS FOR ENHANCED INNATE IMMUNITY

      
Document Number 03019515
Status Pending
Filing Date 2017-03-31
Open to Public Date 2017-10-05
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • THE REGENTS OF THE UNIVERSITY OF COLORADO (USA)
Inventor
  • Dow, Steven
  • Lappin, Michael
  • Wheat, William
  • Chow, Lyndah
  • Regan, Daniel
  • Anchordoquy, Thomas

Abstract

The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands; and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.

IPC Classes  ?

  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • A61K 9/127 - Liposomes
  • A61P 37/04 - Immunostimulants

17.

SYNERGISTIC BACTERIAL CONSORTIA FOR MOBILIZING SOIL PHOSPHORUS

      
Document Number 02968820
Status In Force
Filing Date 2015-11-06
Open to Public Date 2016-06-02
Grant Date 2020-10-20
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Wallenstein, Matthew D.
  • Bell, Colin W.

Abstract

The present disclosure relates to consortia of bacteria strains and composition comprising one or more bacterial strains disclosed herein. These consortia of isolated bacteria cultures and compositions comprising said cultures, having greater activity than would be observed for the individual bacteria cultures and compositions. A composition of the disclosure may advantageously be used for enhancing the availability of soil phosphorus and other macronutrients and/or micronutrients to plants, and thereby enhancing their growth and yield.

IPC Classes  ?

  • C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
  • C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity
  • C12N 1/20 - Bacteria; Culture media therefor

18.

SYNERGISTIC BACTERIAL CONSORTIA FOR MOBILIZING SOIL PHOSPHORUS

      
Document Number 03092129
Status In Force
Filing Date 2015-11-06
Open to Public Date 2016-06-02
Grant Date 2022-05-10
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Wallenstein, Matthew D.
  • Bell, Colin W.

Abstract

ABSTRACT The present disclosure relates to consortia of bacteria strains and composition comprising one or more bacterial strains disclosed herein. These consortia of isolated bacteria cultures and compositions comprising said cultures, having greater activity than would be observed for the individual bacteria cultures and compositions. A composition of the disclosure may advantageously be used for enhancing the availability of soil phosphorus and other macronutrients and/or micronutrients to plants, and thereby enhancing their growth and yield. Date Recue/Date Received 2020-09-04

IPC Classes  ?

  • C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
  • C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity
  • C09K 17/00 - Soil-conditioning materials or soil-stabilising materials
  • C12N 1/20 - Bacteria; Culture media therefor

19.

STEM CELL-DERIVED HEPATOCYTES IN CO-CULTURE AND USES THEREOF

      
Document Number 02936838
Status Pending
Filing Date 2015-01-14
Open to Public Date 2015-07-23
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Khetani, Salman R.
  • Berger, Dustin R.
  • Ware, Brenton R.

Abstract

The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.

IPC Classes  ?

20.

GLYCOSAMINOGLYCAN AND SYNTHETIC POLYMER MATERIALS FOR BLOOD-CONTACTING APPLICATIONS

      
Document Number 02866315
Status In Force
Filing Date 2013-03-11
Open to Public Date 2013-09-19
Grant Date 2021-03-02
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • James, Susan P.
  • Dean, Harold, Iv
  • Dasi, Lakshmi Prasad
  • Forleo, Marcio H.
  • Popat, Ketul C.
  • Lewis, Nicole R.
  • Prawel, David Alois

Abstract

Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.

IPC Classes  ?

  • C08L 5/08 - Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
  • A61F 2/24 - Heart valves
  • A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
  • A61L 33/08 - Polysaccharides
  • C08J 3/20 - Compounding polymers with additives, e.g. colouring
  • C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
  • C08L 23/06 - Polyethene
  • C08L 23/12 - Polypropene
  • C08L 27/18 - Homopolymers or copolymers of tetrafluoroethene
  • C08L 67/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
  • C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
  • C08L 75/04 - Polyurethanes
  • C08L 83/04 - Polysiloxanes

21.

GAS FLUX MEASUREMENT USING TRAPS

      
Document Number 02843646
Status In Force
Filing Date 2012-08-03
Open to Public Date 2013-02-07
Grant Date 2019-10-22
Owner
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
  • CHEVRON U.S.A. INC. (USA)
Inventor
  • Zimbron, Julio A.
  • Sale, Thomas C.
  • Lyverse, Mark

Abstract

A passive sampling apparatus and method for measuring the cumulative mass of a selected gas being transported through a known cross-sectional area, for example, a soil surface, during a chosen period of time, using absorbent material, are described. Two quantities of absorbent material are disposed in a hollow container, such as a pipe section, and spaced apart such that they may be readily separated for analysis. The absorbent material closest to the soil captures the gas leaving the soil. Under reversed flow conditions, for example when the ambient air enters the ground because of fluctuations in atmospheric pressure, the upper absorbent material captures the component of interest entering the apparatus, thereby preventing this gas from entering the lower material and disturbing the measurement. The apparatus can therefore sequester the component of interest without being affected by the direction of gas transport.

IPC Classes  ?

  • G01V 9/00 - Prospecting or detecting by methods not provided for in groups

22.

DEVICE AND SYSTEM FOR TRANSCATHETER MITRAL VALVE REPLACEMENT

      
Document Number 02783282
Status In Force
Filing Date 2010-12-08
Open to Public Date 2011-06-16
Grant Date 2018-04-03
Owner
  • AVALON MEDICAL LTD. (USA)
  • COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Schankereli, Kemal
  • Orton, E. Christopher

Abstract

This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

IPC Classes  ?

23.

RESOLUTION ENHANCEMENT SYSTEM FOR NETWORKED RADARS

      
Document Number 02778476
Status In Force
Filing Date 2010-10-20
Open to Public Date 2011-04-28
Grant Date 2018-03-27
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Venkatachalam, Chandrasekaran
  • Bharadwaj, Nitin

Abstract

Embodiments provide methods, systems, and/or devices that can provide measurements of the inherent reflectivity distribution from different look angles using N radar nodes. Doppler weather radars generally operate with very good spatial resolution in range and poor cross range resolution at farther ranges. Embodiments provide methodologies to retrieve higher resolution reflectivity data from a network of radars. In a networked radar environment, each radar may observe a common reflectivity distribution with different spreading function. The principle that the underlying reflectivity distribution should remain identical for all the nodes may be used to solve the inverse problem to determine intrinsic reflectivities.

IPC Classes  ?

  • G01S 13/87 - Combinations of radar systems, e.g. primary radar and secondary radar

24.

NETWORKED WAVEFORM SYSTEM

      
Document Number 02723754
Status In Force
Filing Date 2009-05-07
Open to Public Date 2009-11-19
Grant Date 2013-10-08
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Venkatachalam, Chandrasekaran
  • Bharadwaj, Nitin

Abstract

Certain embodiments provide a network waveform system that can include multiple radars disposed at different geographical positions within an environment. The multiple radars may be configured to transmit a network waveform. The network waveform may include multiple radar waveforms. Each radar waveform of the multiple waveforms may be transmitted by a specific radar of the multiple radars. The system can also include a computer system coupled with the multiple radars that can include a processor and a memory. The memory may be configured to store information including data received from the multiple radars, data processed by the processor, and processing code executable by the processor. The processing code may include instructions to receive output data from the multiple radars resulting from the transmitted network waveform instructions to jointly process the output data from the multiple radars to determine a measurement of the environment based on the network waveform.

IPC Classes  ?

  • G01S 13/87 - Combinations of radar systems, e.g. primary radar and secondary radar
  • G01S 13/58 - Velocity or trajectory determination systems; Sense-of-movement determination systems
  • G01S 13/95 - Radar or analogous systems, specially adapted for specific applications for meteorological use
  • G01S 13/522 - Discriminating between fixed and moving objects or between objects moving at different speeds using transmissions of interrupted pulse modulated waves

25.

DUAL-POLARIZATION RADAR PROCESSING SYSTEM USING TIME DOMAIN METHOD

      
Document Number 02723720
Status In Force
Filing Date 2009-05-07
Open to Public Date 2009-11-12
Grant Date 2014-12-23
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Venkatachalam, Chandrasekaran
  • Nguyen, Cuong M.
  • Moisseev, Dmitri N.

Abstract

Embodiments of the present invention provide for improved estimation of environmental parameters in a dual-polarization radar system. In some embodiments, environmental parameters can be estimated using a linear combination of data received in two orthogonal polarization states. In particular, embodiments of the invention improve ground clutter and noise mitigation in dual polarization radar systems. Moreover, embodiments of the invention also provide for systems to determine the differential reflectivity and/or the magnitude of the co-polar correlation coefficient and the differential phase in a dual polariza-tion radar system.

IPC Classes  ?

  • G01S 7/02 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
  • G01S 13/95 - Radar or analogous systems, specially adapted for specific applications for meteorological use

26.

OUTER LAYER MATERIAL HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST BLENDED WITH A MALEATED HYDROPHOBIC POLYMER CO-HOST, AND HYDROPHILIC POLYMER GUEST

      
Document Number 02721924
Status In Force
Filing Date 2009-04-21
Open to Public Date 2009-10-29
Grant Date 2016-03-22
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • James, Susan P.
  • Zhang, Min
  • Beauregard, Guy
  • Oldinski, Rachael Kurkowski

Abstract

An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.

IPC Classes  ?

  • C08J 9/40 - Impregnation
  • C08L 5/08 - Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
  • C09D 105/00 - Coating compositions based on polysaccharides or on their derivatives, not provided for in groups or
  • C08B 37/00 - Preparation of polysaccharides not provided for in groups ; Derivatives thereof
  • C08F 8/12 - Hydrolysis
  • C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
  • C08L 101/00 - Compositions of unspecified macromolecular compounds

27.

DYNAMIC AND ADAPTIVE RADAR TRACKING OF STORMS (DARTS)

      
Document Number 02717733
Status In Force
Filing Date 2009-03-04
Open to Public Date 2009-09-11
Grant Date 2015-05-19
Owner COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventor
  • Venkatachalam, Chandrasekaran
  • Xu, Gang
  • Wang, Yanting

Abstract

Methods and systems for estimating atmospheric conditions are disclosed according to embodiments of the invention. In one embodiment, a method may include receiving reflective atmospheric data and solving a flow equation for motion coefficients using the reflective atmospheric data. Future atmospheric conditions can be estimated using the motion coefficients and the reflective atmospheric data. In another embodiment of the invention, the flow equation is solved in the frequency domain. Various linear regression tools may be used to solve for the coefficients. In another embodiment of the system, a radar system is disclosed that predicts future atmospheric conditions by solving the spectral flow equation.

IPC Classes  ?

  • G01W 1/10 - Devices for predicting weather conditions
  • G01S 13/95 - Radar or analogous systems, specially adapted for specific applications for meteorological use