This disclosure provides equipment, systems and methods for isolating nucleic acids from cells, preferably in a continuous manner, using a reactor system.
This disclosure relates to large-scale bioreactor systems comprising a vessel comprising internal reaction chamber having a volumetric and cell-sustaining capacity significantly above that of currently available bioreactor systems.
This disclosure generally relates to purification systems using tangential flow filtration ("TFF") ("TFF systems") that include at least one single-use, disposable flow path wherein the disposable flow path is comprised of a disposable cassette manifold, disposable tubing (including associated components) and a disposable reactor vessel.
This disclosure relates to reaction container systems providing for headspace-based condensation, coalescing devices, and other features. In some embodiments, this disclosure provides systems that reduce the relative humidity (RH) of an exhaust gas prior to or concurrent with its explusion from the system through an exhaust filter.
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs), and particular those used for storing and/or supplying buffers and other solutions in systems for carrying out reactions in reaction vessels. In some embodiments, the DC comprises a first and second end, one or more attachment connectors at the first end, and one or more conveyance connectors at the second end. Systems comprising and methods for using and/or testing the same are also disclosed.
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65B 1/00 - Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided. The mobile carriage may optionally comprise at least one implement selected from the group consisting of at least one wheel or track, and implement providing for fixably attaching the disposable reaction container to the carriage, an implement providing for fixably attaching the carriage to the holder, and an implement for mixing the components of the reaction.
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C07K 1/00 - General processes for the preparation of peptides
C07K 2/00 - Peptides of undefined number of amino acids; Derivatives thereof
C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising at least one distribution channel and at least one relief channel are provided. In another embodiment two sub-assemblies comprising said distribution and relief channels adjoined to one another are provided.
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