This disclosure provides equipment, systems and methods for isolating nucleic acids from cells, preferably in a continuous manner, using a reactor system.
This disclosure generally relates to purification systems using tangential flow filtration (“TFF”) (“TFF systems”) that include at least one single-use, disposable flow path wherein the disposable flow path is comprised of a disposable cassette manifold, disposable tubing (including associated components) and a disposable reactor vessel.
This disclosure relates to large-scale bioreactor systems comprising a vessel comprising internal reaction chamber having a volumetric and cell-sustaining capacity significantly above that of currently available bioreactor systems.
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65D 21/02 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
C12M 1/00 - Apparatus for enzymology or microbiology
A cell culture bioreactor has membranes divided into a plurality of zones. The membranes may include perfusion membranes carrying a liquid media and/or gas transfer membranes. The bioreactor has one or more sensors configured to collect data from one or more locations within the bioreactor. The supply of one or more of the gaseous and/or liquid media to a selected zone or zones may be controlled. In some examples, the supply includes a background supply and a selectable incremental supply. The bioreactor may be used to grow cells in suspension. Liquid media circulates within an extra-capillary space of the bioreactor. In some examples, a portion of cells is permitted for a period of time to be restrained within one or more zones of the membranes. Elements of a reactor may be made in a mold. A reactor may be operated in a fed-batch process.
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.
C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
B01J 8/20 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium
B01J 19/18 - Stationary reactors having moving elements inside
F28D 9/00 - Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
F28F 13/12 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by creating turbulence, e.g. by stirring, by increasing the force of circulation
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
F28F 9/22 - Arrangements for directing heat-exchange media into successive compartments, e.g. arrangements of guide plates
B01J 19/24 - Stationary reactors without moving elements inside
C12M 1/00 - Apparatus for enzymology or microbiology
F28F 3/00 - Plate-like or laminated elements; Assemblies of plate-like or laminated elements
This disclosure generally relates to purification systems using tangential flow filtration ("TFF") ("TFF systems") that include at least one single-use, disposable flow path wherein the disposable flow path is comprised of a disposable cassette manifold, disposable tubing (including associated components) and a disposable reactor vessel.
This disclosure generally relates to purification systems using tangential flow filtration ("TFF") ("TFF systems") that include at least one single-use, disposable flow path wherein the disposable flow path is comprised of a disposable cassette manifold, disposable tubing (including associated components) and a disposable reactor vessel.
This disclosure relates to reaction container systems providing for headspace-based condensation, coalescing devices, and other features. In some embodiments, this disclosure provides systems that reduce the relative humidity (RH) of an exhaust gas prior to or concurrent with its expulsion from the system through an exhaust filter.
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
B01D 45/06 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by utilising inertia by reversal of direction of flow
B01D 45/16 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces generated by the winding course of the gas stream
B01D 50/20 - Combinations of devices covered by groups and
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.
C12M 1/00 - Apparatus for enzymology or microbiology
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 19/18 - Stationary reactors having moving elements inside
C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
B01F 27/072 - Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
B01F 27/805 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle
B01F 27/902 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms cooperating with intermeshing elements fixed on the receptacle walls
B01F 33/00 - Other mixers; Mixing plants; Combinations of mixers
B01F 33/501 - Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
B01F 35/92 - Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
B01F 35/45 - Closures or doors specially adapted for mixing receptacles; Operating mechanisms therefor
B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
B01F 35/53 - Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
B01J 19/24 - Stationary reactors without moving elements inside
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65D 21/02 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
C12M 1/00 - Apparatus for enzymology or microbiology
A cell culture bioreactor has perfusion membranes and gas transfer membranes or a gas phase in an extra-membrane space in contact with a film on the perfusion membranes. Gas transfer membranes may travel through the perfusion membranes or through the extra-membrane space. Examples with hollow fiber and flat sheet membranes are shown. One or more of the membranes optionally has a responsive surface, for example a thermo-responsive surface. In some examples, membranes are located in X-Y planes while the length of the reactor extends in a Z-direction.
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs), and particular those used for storing and/or supplying buffers and other solutions in systems for carrying out reactions in reaction vessels. In some embodiments, the DC comprises a first and second end, one or more attachment connectors at the first end, and one or more conveyance connectors at the second end. Systems comprising and methods for using and/or testing the same are also disclosed.
A cell culture bioreactor has membranes divided into a plurality of zones. The membranes may include perfusion membranes carrying a liquid media and/or gas transfer membranes. The bioreactor has one or more sensors configured to collect data from one or more locations within the bioreactor. The supply of one or more of the gaseous and/or liquid media to a selected zone or zones may be controlled. In some examples, the supply includes a background supply and a selectable incremental supply. The bioreactor may be used to grow cells in suspension. Liquid media circulates within an extra-capillary space of the bioreactor. In some examples, a portion of cells is permitted for a period of time to be restrained within one or more zones of the membranes. Elements of a reactor may be made in a mold. A reactor may be operated in a fed- batch process.
A cell culture bioreactor has membranes divided into a plurality of zones. The membranes may include perfusion membranes carrying a liquid media and/or gas transfer membranes. The bioreactor has one or more sensors configured to collect data from one or more locations within the bioreactor. The supply of one or more of the gaseous and/or liquid media to a selected zone or zones may be controlled. In some examples, the supply includes a background supply and a selectable incremental supply. The bioreactor may be used to grow cells in suspension. Liquid media circulates within an extra-capillary space of the bioreactor. In some examples, a portion of cells is permitted for a period of time to be restrained within one or more zones of the membranes. Elements of a reactor may be made in a mold. A reactor may be operated in a fed-batch process.
A cell culture bioreactor has perfusion membranes and gas transfer membranes or a gas phase in an extra-membrane space in contact with a film on the perfusion membranes. Gas transfer membranes may travel through the perfusion membranes or through the extra-membrane space. Examples with hollow fiber and flat sheet membranes are shown. One or more of the membranes optionally has a responsive surface, for example a thermo-responsive surface. In some examples, membranes are located in X-Y planes while the length of the reactor extends in a Z-direction.
37 - Construction and mining; installation and repair services
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Technical consultancy services related to the repair of bioprocessing systems; technical consultation in the field of bioprocessing facility and equipment construction Technical consulting related to the manufacturing of pharmaceuticals; consultation in the field of custom fabrication of bioprocessing systems Providing technical advice in the field of bioengineering; research, development, engineering, and testing services in the pharmaceutical field; custom design and engineering of bioprocess systems; technology consultation in the field of pharmaceuticals; consulting services in the field of design and development of bioengineering processes; consulting in the field of bioengineering; technical consultation in the field of pharmaceutical science, design for others in the field of bioengineering, designing and testing of bioengineering products for others; professional consulting services in the fields of bioengineering
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65D 21/02 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
C12M 1/00 - Apparatus for enzymology or microbiology
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.
C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
B01J 8/20 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
B01J 19/18 - Stationary reactors having moving elements inside
F28D 9/00 - Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
F28F 13/12 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by creating turbulence, e.g. by stirring, by increasing the force of circulation
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
F28F 9/22 - Arrangements for directing heat-exchange media into successive compartments, e.g. arrangements of guide plates
B01J 19/24 - Stationary reactors without moving elements inside
C12M 1/00 - Apparatus for enzymology or microbiology
F28F 3/00 - Plate-like or laminated elements; Assemblies of plate-like or laminated elements
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
This disclosure relates to reaction container systems providing for headspace-based condensation, coalescing devices, and other features. In some embodiments, this disclosure provides systems that reduce the relative humidity (RH) of an exhaust gas prior to or concurrent with its explusion from the system through an exhaust filter.
This disclosure relates to reaction container systems providing for headspace-based condensation, coalescing devices, and other features. In some embodiments, this disclosure provides systems that reduce the relative humidity (RH) of an exhaust gas prior to or concurrent with its explusion from the system through an exhaust filter.
A cell culture bioreactor has perfusion membranes and gas transfer membranes or a gas phase in an extra-membrane space in contact with a film on the perfusion membranes. Gas transfer membranes may travel through the perfusion membranes or through the extra-membrane space. Examples with hollow fiber and flat sheet membranes are shown. One or more of the membranes optionally has a responsive surface, for example a thermo-responsive surface. In some examples, membranes are located in X-Y planes while the length of the reactor extends in a Z-direction.
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs), and particular those used for storing and/or supplying buffers and other solutions in systems for carrying out reactions in reaction vessels. In some embodiments, the DC comprises a first and second end, one or more attachment connectors at the first end, and one or more conveyance connectors at the second end. Systems comprising and methods for using and/or testing the same are also disclosed.
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs), and particular those used for storing and/or supplying buffers and other solutions in systems for carrying out reactions in reaction vessels. In some embodiments, the DC comprises a first and second end, one or more attachment connectors at the first end, and one or more conveyance connectors at the second end. Systems comprising and methods for using and/or testing the same are also disclosed.
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.
C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
B01J 8/20 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 19/18 - Stationary reactors having moving elements inside
F28D 9/00 - Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
F28F 13/12 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by creating turbulence, e.g. by stirring, by increasing the force of circulation
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
F28F 9/22 - Arrangements for directing heat-exchange media into successive compartments, e.g. arrangements of guide plates
B01J 19/24 - Stationary reactors without moving elements inside
C12M 1/00 - Apparatus for enzymology or microbiology
F28F 3/00 - Plate-like or laminated elements; Assemblies of plate-like or laminated elements
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65D 21/02 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
C12M 1/00 - Apparatus for enzymology or microbiology
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
B65B 55/00 - Preserving, protecting or purifying packages or package contents in association with packaging
B65B 1/00 - Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
C12M 1/00 - Apparatus for enzymology or microbiology
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
B01J 8/20 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 19/18 - Stationary reactors having moving elements inside
F28D 9/00 - Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
F28F 13/12 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by creating turbulence, e.g. by stirring, by increasing the force of circulation
F28F 9/22 - Arrangements for directing heat-exchange media into successive compartments, e.g. arrangements of guide plates
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 19/18 - Stationary reactors having moving elements inside
B62B 3/04 - Hand carts having more than one axis carrying transport wheels; Steering devices therefor; Equipment therefor involving means for grappling or securing in place objects to be carried; Load handling equipment
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/00 - General processes for the preparation of peptides
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided. The mobile carriage may optionally comprise at least one implement selected from the group consisting of at least one wheel or track, and implement providing for fixably attaching the disposable reaction container to the carriage, an implement providing for fixably attaching the carriage to the holder, and an implement for mixing the components of the reaction.
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C07K 1/00 - General processes for the preparation of peptides
C07K 2/00 - Peptides of undefined number of amino acids; Derivatives thereof
C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
09 - Scientific and electric apparatus and instruments
Goods & Services
Bioreactor for cell culturing; Disposable plastic bioreactors for cell culturing; Incubators for bacteria culture; Laboratory chemical reactors; Laboratory equipment and supplies, namely, incubators
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising at least one distribution channel and at least one relief channel are provided. In another embodiment two sub-assemblies comprising said distribution and relief channels adjoined to one another are provided.
This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising at least one distribution channel and at least one relief channel are provided. In another embodiment two sub-assemblies comprising said distribution and relief channels adjoined to one another are provided.
