Abstract

Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.

IPC Classes  ?

• C08F 222/12 - Esters of phenols or saturated alcohols
• C08F 122/20 - Esters containing oxygen in addition to the carboxy oxygen
• C07C 57/04 - Acrylic acid; Methacrylic acid
• C07C 69/54 - Acrylic acid esters; Methacrylic acid esters
• A61K 31/78 - Polymers containing oxygen of acrylic acid or derivatives thereof

Abstract

Disclosed is a laser system including a first laser and a second laser. The first laser includes a laser cavity, and a gas phase molecular gain medium disposed in the laser cavity, the gain medium having an absorption band. The second laser is a solid state laser configured to be continuously tunable, with respect to an emission wavelength of the second laser, over the absorption band of the gain medium, and the second laser is tuned to pump rotational vibrational transitions in the gain medium to achieve a rotational population inversion.

IPC Classes  ?

• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/14 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range characterised by the material used as the active medium
• H01S 3/22 - Gases
• H01S 3/223 - Gases the active gas being polyatomic, i.e. containing two or more atoms
• H01S 5/00 - Semiconductor lasers

Abstract

A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end and a non-contact optical connection arranged at an end of the rail body and configured to interface with a corresponding non-contact optical interface. A low speed data bus segment extends between the receiver end and the muzzle end of the rail body. A high speed data spoke is connected to the non-contact optical connection for high speed data communication with a high speed data accessory through the non-contact optical connection and the corresponding noncontact optical interface. Tactical rail systems and firearm assemblies having tactical rails are also described.

IPC Classes  ?

• F41G 11/00 - WEAPON SIGHTS; AIMING - Details of sighting or aiming apparatus; Accessories
• F41C 27/00 - SMALLARMS, e.g. PISTOLS OR RIFLES; ACCESSORIES THEREFOR - Details or attachments not otherwise provided for

Abstract

222 measurements are transformed into a novel metric known as Accumulated Hypoxic Debt (AHD). The AHD metric is used as the independent variable in a longitudinal generalized linear mixed model to calculate the probability D that the subject is at risk of AMS. Based on the probability D, appropriate courses of action may be communicated to the subject via the output device of a wearable or portable monitor.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/22 - Ergometry; Measuring muscular strength or the force of a muscular blow
• A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases

Abstract

Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components.

IPC Classes  ?

• C22C 21/00 - Alloys based on aluminium
• E21B 23/06 - Apparatus for displacing, setting, locking, releasing or removing tools, packers or the like in boreholes or wells for setting packers
• E21B 33/12 - Packers; Plugs

Abstract

An apparatus for improving dexterity of the bare hands in cold temperatures includes heating pads 10 disposed on the forehead, cheeks and forearms. The heating pads 10a, 10b, 10c on the forehead and cheeks stimulate the trigeminal nerve area to increase blood flow to the fingers. The heating pads 10d, 10d on the forearms 24, 24 increase the temperature of the blood flowing to the hands. Thermocouples 32 in each heating pad 10 are connected to a set- point controller 28.

IPC Classes  ?

• A41D 13/005 - Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches with controlled internal environment with controlled temperature
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

Disclosed herein are methods of making attenuated Arenaviruses, compositions comprising the attenuated Arenaviruses, and methods of using the attenuated Arenaviruses. As disclosed herein, the attenuated Arenaviruses have a deletion of at least a portion of the intergenic region (IGR) of one or both genome segments.

IPC Classes  ?

• C12R 1/92 - Viruses
• C07K 14/08 - RNA viruses
• C12N 15/86 - Viral vectors
• A61P 31/14 - Antivirals for RNA viruses
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• A61K 35/76 - Viruses; Subviral particles; Bacteriophages

Abstract

An apparatus (8) for isolating corneal endothelial cells (34) (CECs) includes a base portion (10) having an interior recessed opening (14) with a bottom surface (16). A convex projection (18) is centrally located on the bottom surface (16) and is configured to receive an inverted cornea (32). A top portion (12) is configured to mate with the base portion (10). The top portion (12) includes a fluid chamber (24) with a lower surface (20). The lower surface (20) has an opening (22) therein in which the convex projection (18) projects when the top portion (12) is mated with the base portion (10).

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

An airway management device (10) for a human or animal subject (20) includes an airway tube (101) having a first end for disposal external to the subject (20) and a second end (102) for disposal in a portion of an airway of the subject (20). A light emitting element (108) and a photosensing element (109) may be disposed at the second end (102) of the airway tube (101). The light emitting element (108) may be configured to transmit light to tissue adjacent to the light emitting element (108). The photosensing element (109) may be configured to receive reflectance spectra (204) from the tissue. The location of the second end (102) of the airway tube (101) may be determined from characteristics of the reflectance spectra (204) of the tissue.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
• A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

Brain impairment, for example due to stroke, is corrected in order to improve body movement. An fNIRS device is positioned over the motor cortex of non-impaired individuals, and blood oxygen in locations of the brain is analyzed to determine brain activity corresponding to a particular body movement. The movements are statistically analyzed, and are compared with fNIRS data gathered from a movement impaired individual attempting the same movement. A weighted value corresponding to the desired brain activity is generated using the statistical analysis, and is graphically displayed to the movement impaired individual during the attempts. This produces a feedback loop relating to the movement which can be repeated to produce brain plasticity in the impaired individual to facilitate the movement. Additionally, correct brain activity can be used to cause the application of an electrical signal to muscles of the body to produce the desired movement.

IPC Classes  ?

• A61B 5/0482 - Electroencephalography using biofeedback
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
• A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06K 9/40 - Noise filtering

Abstract

Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL).

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for preventing, ameliorating or treating disease caused by dengue vims in a subject in need thereof comprising administering to the subject a dengue vaccine formulation in combination with a NS3 helicase polypeptide and/or fragment(s) thereof, wherein said method comprises stimulating humoral as well as cell- mediated immunity to the dengue virus in the subject,

IPC Classes  ?

• A61K 39/12 - Viral antigens
• C07K 1/00 - General processes for the preparation of peptides
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/12 - Viral antigens
• A61P 31/14 - Antivirals for RNA viruses

Abstract

An apparatus (18) for mounting surgical rails (40, 42) to a litter (10) having a pair of parallel poles (12) includes a pair of longitudinal members (20, 22) fixed to outboard sides of respective ones of the pair of poles (12). A pair of surgical rails (40, 42) is fixed to outboard surfaces of respective ones of the pair of longitudinal members (20, 22). Clamps (24, 26, 28, 30) at each end of each longitudinal member (20, 22) fix the longitudinal members (20, 22) to the pair of poles (12). A pair of cross bars (36, 38) extend between and are fixed to opposing clamps (24, 26, 28, 30) at each end of each longitudinal member (20, 22).

IPC Classes  ?

• A61G 1/04 - Parts, details or accessories, e.g. head-, foot-, or like rests specially adapted for stretchers

Abstract

An arthropod trap (10) includes a source (60) of CO2 gas. The CO2 gas is released proximate the arthropod trap (10). The source (60) of the CO2 gas includes an inflatable bladder (42) filled with breath (46) that was exhaled by a human being (100).

IPC Classes  ?

• A01M 1/02 - Stationary means for catching or killing insects with devices attracting the insects
• A01M 1/10 - Traps

Abstract

A computer-assisted surgical system can include a donor sub-system and a recipient sub¬ system. The donor sub-system includes a first reference unit having a first trackable element, a fragment reference unit having a second trackable element, and a first detector configured to provide at least one of a first signal corresponding to a detected location of one or more of the first trackable element and the second trackable element. The recipient sub-system includes a second reference unit having a third trackable element, and a second detector configured to provide at least one of a second signal corresponding to a detected location of at least the third trackable element.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/16 - Osteoclasts; Drills or chisels for bones; Trepans
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
• A61F 2/28 - Bones

Abstract

Provided herein is a computer-implemented method, system, computer-readable medium operable to perform the method for cephalometry for orthognathic and craniomaxillofacial surgery. The method can include transforming a set of cephalometric landmarks from a donor or mobile skeletal fragment in a first reference frame to a second reference frame based on a registration process that maps coordinates from the first reference frame to coordinates in the second reference frame; tracking movement, based on one or more signals from one or more sensors, during surgery, of one or more of the cephalometric landmarks in the set of cephalometric landmarks associated with the donor or mobile skeletal fragment with respect to one or more of the cephalometric landmarks in the set of cephalometric landmarks associated with a recipient or second skeletal portion in the second reference frame; calculating one or more cephalometry metrics; and providing an update of the one or more cephalometry metrics.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Abstract

A pelvic trauma device for emergency treatment of pelvic fracture includes two parallel elongated straps or belts that are connected, but are adjusted independently of each other. The two parallel belts include a lower belt and an upper belt. The two parallel belts are independently tensioned to provide: 1) pelvic fracture stabilization (lower belt); and 2) compression over the sacrum and anterior abdomen (upper belt).

IPC Classes  ?

• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
• A61F 5/02 - Orthopaedic corsets
• A61F 13/02 - Adhesive plasters or dressings

Abstract

his invention relates generally to the discovery of improved food-grade protein matrices with reduced allergeiiicity and uses thereof including immunotherapy.

IPC Classes  ?

• A23L 1/29 - Modifying nutritive qualities of foods; Dietetic products ( A23L 1/09 takes precedence;dietetic salt substitutes A23L 1/22)
• A23L 1/20 - Treatment of pulse, i.e. fruits of leguminous plants, for production of fodder or food; Preparation of products from legumes; Chemical means for rapid cooking of these foods, e.g. treatment with phosphates

Abstract

A method and a system of estimating core temperatures of battery cells in a battery pack can include several steps. In one step, a surface temperature of one or more battery cell(s) is received, a current of the one or more battery cell(s) is received, an inlet temperature of coolant provided to the battery pack is received, and a flow rate or velocity of the coolant is received. In another step, estimations are made including those of a cell-lumped internal electrical resistance of the battery cell(s), a cell-lumped conduction resistance between a core and a surface of the battery cell(s), and a cell- lumped convection resistance between the surface and the coolant. In yet another step, an estimation is made of a core temperature of the battery cell(s) based upon the received and estimated values of previous steps.

IPC Classes  ?

• H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
• H01M 10/50 - Heating or cooling or regulating temperature (control of temperature in general G05D 23/00)

Abstract

Methods for the synthesis of toeofiexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material

IPC Classes  ?

• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Abstract

A two person portable apparatus (10) for reducing the core temperature of one or more human beings includes a trough (14) made of a waterproof, flexible fabric (56) and a generally rectangular frame (12). Portions (68, 70, 72, 74) of the fabric (56) are looped over sides (24, 26, 28, 30) of the frame (12) so that the trough is supported by and suspended from the frame. The apparatus includes four legs (16, 18, 20, 22) hinged to corners of the frame and pivotable inwardly under the trough. Cooling water is placed in the trough and the hands and forearms of human beings are immersed in the cooling water.

IPC Classes  ?

• A47K 3/06 - Collapsible baths
• A61H 35/00 - Baths for specific parts of the body, e.g. breast douches
• E04H 4/00 - Swimming or splash baths or pools

Abstract

A macro photographic apparatus for creating focus stacked images of a specimen may include a rigid longitudinal member having a longitudinal axis and including a camera mount thereon. A translation device may be fixed to the member for translating the specimen along the member toward and away from the camera mount. A rotation device may be mounted on the translation device. The rotation device may support the specimen and enable rotation of the specimen around first and second axes that are perpendicular to the longitudinal axis of the member. At any single position of the translation device along the longitudinal axis of the member, as the specimen is rotated around the first and second axes, the spatial location of the specimen remains substantially the same.

IPC Classes  ?

• G02B 27/22 - Other optical systems; Other optical apparatus for producing stereoscopic or other three-dimensional effects
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light

Abstract

This invention describes the preparation of a series of compounds that can be used as co-solvents, solutes or additives in non-aqueous electrolytes and their test results in various electrochemical devices. The inclusion of these novel compounds in electrolyte systems can enable rechargeable chemistries at high voltages that are otherwise impossible with state-of-the-art electrolyte technologies. These compounds are so chosen because of their beneficial effect on the interphasial chemistries formed at high potentials, such as 5.0 V class cathodes for new Li ion chemistries. The potential application of these compounds goes beyond Li ion battery technology and covers any electrochemical device that employs non-aqueous electrolytes for the benefit of high energy density resultant from high operating voltages.

IPC Classes  ?

• H01M 4/52 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron
• C01G 51/04 - Oxides; Hydroxides

Abstract

Functionalized polymer matrix and/or reinforcement materials that are capable of a thermoreversible Diels-Alder reaction are useful for making composite materials. Also disclosed is a composite material which includes one or both of functionalized reinforcement materials and functionalized polymer matrix materials, as well as a method for repairing a composite material including the step of thermally treating the composite material at a temperature sufficient to react a functionality on one of the reinforcement material and the polymer matrix material with another functionality via a Diels-Alder reaction. A method of making a composite material including functionalizing one or both of a reinforcing material and a polymer matrix material with a first reactive group, providing a second reactive group capable of undergoing a Diels-Alder reaction with the first reactive group and reacting the first and second reactive groups to form a composite material, is also described.

IPC Classes  ?

• C08K 5/3415 - Five-membered rings
• C08L 71/02 - Polyalkylene oxides
• C08G 65/20 - Tetrahydrofuran
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule; Polyhydrazides; Polyamide acids or similar polyimide precursors
• C07D 307/52 - Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

A hazardous materials protective garment may use a two-stage evaporative cooling process to ease heat strain on the wearer of the garment. The garment may include an impermeable inner layer and a wicking outer layer. One or more reservoirs may be disposed interior to the inner layer for collecting condensed and/or unevaporated sweat. One or more pumps may move the sweat to the exterior of the impermeable layer for distribution in the wicking layer and evaporation from the garment.

IPC Classes  ?

• A41D 13/005 - Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches with controlled internal environment with controlled temperature
• A41D 13/02 - Overalls
• A41D 13/00 - Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches

Abstract

The present invention relates to an isolated anaerobic bacterium Bacteroides sp. for use as a fϊbro-biotic for livestock. More specifically, the fibro-biotic supplements a fiber diet to Sus scrofa scrofa with the fibro-biotic improving fiber digestion and decreasing fecal output in these livestock. The present invention also relates to the use of the isolated bacterium as a food composition to improve the health of monogastric livestock and as a feed supplement to livestock.

IPC Classes  ?

• C12N 1/20 - Bacteria; Culture media therefor
• C12N 11/02 - Enzymes or microbial cells immobilised on or in an organic carrier
• A23K 1/16 - supplemented with accessory food factors; Salt blocks
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

IPC Classes  ?

• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves

Abstract

Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.

IPC Classes  ?

• A61K 31/47 - Quinolines; Isoquinolines
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61P 33/00 - Antiparasitic agents
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• A61P 33/06 - Antimalarials
• C07D 215/14 - Radicals substituted by oxygen atoms
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention relates to a lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen derived from Hepatitis B.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 39/29 - Hepatitis virus

Abstract

The present invention relates to a hybrid/ fusion protein derived from the CS protein of Plasmodium vivax (P. vivax), methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, for example those caused by P. vivax, compositions/vaccines containing the protein or antibodies against the protein such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. The invention also extends to lipoprotein particles of said hybrid protein and formulations/vaccines comprising the same and use thereof. In particular it relates to an immunogenic hybrid fusion protein comprising: a. at least one repeat unit derived from the repeating region of a type I circumsporozoite protein of P. vivax, b. at least one repeat unit derived from the repeating region of a type II circumsporozoite protein of P. vivax, and surface antigen S derived from Hepatitis B virus, or a fragment thereof

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 39/29 - Hepatitis virus

Abstract

A KE rod warhead for artillery rockets contains a multiplicity of KE rod penetrators (202) packaged into tier packs (104A, 104B, 104C) that are stacked and positioned around a center column (102) of the warhead. The warhead has a skin (105) that is severed when the rocket enters its target area. The KE rods (202) are situated and housed in such a manner that they experience a minimum of pitching or tumbling as they are released from the rocket and enter the airstream. As a result, the rods have optimum lethality against their target. The KE rod artillery rocket warhead contains no explosive munitions, so it can be used without contaminating the target area with unexploded ordnance.

IPC Classes  ?

• F42B 12/60 - Cluster or cargo ammunition, i.e. projectiles containing one or more submissiles the submissiles being ejected radially

Abstract

Disclosed are lipids, annexin, and lipid-annexin complexes for use in the prevention and/or treatment of ischemia-reperfusion injury and reperfusion injury associated with a variety of diseases and conditions. Also disclosed are therapeutic targets and compositions for the prevention and treatment of ischemia-reperfusion injury and diseases and conditions associated with ischemia-reperfusion injury.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Abstract

The Trajectory Correction Kit (101) is a completely self-contained retrofit kit that is externally and fixedly mounted as an add-on to the rear of an existing, unguided rocket. The TCK continuously measures the pitch and yaw of the rocket as it is released from the launch tube and during the initial seconds of the flight and calculates the trajectory correction that is necessary to eliminate the measured pitch and yaw. Then it activates selected thrusters among the thrusters (301, 401) that are positioned around the circumference of the rocket body (100) so as to steer the rocket in a direction until the measured pitch and yaw are eliminated.

IPC Classes  ?

• F41G 7/00 - Direction control systems for self-propelled missiles
• F42B 10/00 - Means for influencing, e.g. improving, the aerodynamic properties of projectiles or missiles; Arrangements on projectiles or missiles for stabilising, steering, range-reducing, range-increasing or fall-retarding

Abstract

The present invention comprises a device which utilizes catalytic microcombustion for the production of heat or power and which exhibits a low pressure drop and has a high catalytic surface area. The catalytic microcombustor includes catalyst inserts in the reaction chamber separated by a sub millimeter distance. Thermal spreaders ensure temperature uniformity and maximum thermal efficiency. A mixing zone is prior to the combustion zone. Thermally conductive and/or insulating inserts are in the vicinity of the reaction zone.

IPC Classes  ?

• F02B 71/00 - Free-piston engines; Engines without rotary main shaft

Abstract

The invention relates to transcutaneous and/or transdermal transport of materials, such as antigens, drugs, drugs, nucleic acids, (e.g., DNA and RNA), proteins, other therapeutic agents, dyes, and the like, into the skin and/or the body. The material is transported transcutaneously and/or transdermally using an antigen presenting cell (APC) by applying the APC and the material on to the surface of the skin.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/38 - Antigens from snakes
• A01N 1/02 - Preservation of living parts
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C12N 5/02 - Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor