Life Technologies Corporation

United States of America

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[Owner] Life Technologies Corporation 3,068
Applied Biosystems, LLC 454
Molecular Probes, Inc. 92
Life Technologies AS 78
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IPC Class
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 692
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 266
G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS 202
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides 178
C12M 1/00 - Apparatus for enzymology or microbiology 153
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NICE Class
01 - Chemical and biological materials for industrial, scientific and agricultural use 612
09 - Scientific and electric apparatus and instruments 290
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1.

CELLS-TO-CT

      
Application Number 1787572
Status Registered
Filing Date 2024-03-11
Registration Date 2024-03-11
Owner Life Technologies Corporation (USA)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Reagents for scientific or medical research use.

2.

METHODS, COMPOSITIONS, AND KITS FOR DETECTING ALLELIC VARIANTS

      
Application Number 18087259
Status Pending
Filing Date 2022-12-22
First Publication Date 2024-04-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Chen, Caifu
  • Tan, Ruoying

Abstract

In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”).

IPC Classes  ?

  • C12Q 1/6858 - Allele-specific amplification
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

3.

DURAPLEX

      
Application Number 1786888
Status Registered
Filing Date 2024-02-22
Registration Date 2024-02-22
Owner Life Technologies Corporation (USA)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Reagents for medical diagnostic use in polymerase chain reaction (PCR) to detect and analyze nucleic acids in laboratories, hospitals, point-of-care, and direct consumer applications, and the associated accessory products, namely, medical diagnostic test media in the form of test plates and 96 well plates for use in polymerase chain reaction (PCR) to detect and analyze nucleic acids in laboratories, hospitals, point-of-care and direct consumer applications for use in medical genetic testing.

4.

STAIN-IT

      
Application Number 1786891
Status Registered
Filing Date 2024-02-22
Registration Date 2024-02-22
Owner Life Technologies Corporation (USA)
NICE Classes  ? 42 - Scientific, technological and industrial services, research and design

Goods & Services

Providing on-line non-downloadable software for cellular analysis.

5.

METHODS FOR ANALYSIS OF DNA FRAGMENTS

      
Application Number 18110844
Status Pending
Filing Date 2023-02-16
First Publication Date 2024-04-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Merriman, Barry
  • Mola, Paul
  • Gardner, Mark

Abstract

A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele. The method further includes measuring using a plurality of sensors of the array of sensors a characteristic of the region of the plurality of copies of the sample polynucleotide and determining using a computational circuitry and the measured characteristics a statistical value indicative of the allele.

IPC Classes  ?

  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]

6.

DEVICES, SYSTEMS, AND METHODS FOR PROCESSING BIOLOGICAL SAMPLES USING ISOTACHOPHORESIS

      
Application Number US2023076977
Publication Number 2024/086523
Status In Force
Filing Date 2023-10-16
Publication Date 2024-04-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Chen, I-Jane
  • Castillo, Nestor
  • Green, Robert L.
  • Liu, Liansen

Abstract

A fluidic device for performing isotachophoresis comprise a substrate defining a fluidic network comprising a plurality of inlet channels, the outlets of the inlet channels meeting at a juncture, an intermediate channel extending from the juncture and fluidically coupled to the outlets of the plurality of inlet channels, a first reservoir at the juncture and fluidically coupled to the inlet channels and the intermediate channel, a second reservoir fluidically coupled to the intermediate channel at a location downstream of the juncture, wherein the inlet channels, the collection channel, and the intermediate channel are co-planar, and wherein the first reservoir and second reservoir are configured to produce substantially equal pressure heads. Methods of loading the fluidic device for isotachophoresis can be sequentially through the various inlet channels.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

7.

Bubble trap

      
Application Number 29808190
Grant Number D1024319
Status In Force
Filing Date 2021-09-17
First Publication Date 2024-04-23
Grant Date 2024-04-23
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Hanks, Scott T.
  • Kjar, Steven R.

8.

INTELLITAG

      
Serial Number 98515468
Status Pending
Filing Date 2024-04-23
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Biomolecule labeling kits comprising primarily of reagents for use in clinical and scientific research

9.

MICROCARRIER FILTER BAG ASSEMBLIES AND METHODS OF USE

      
Application Number 18393393
Status Pending
Filing Date 2023-12-21
First Publication Date 2024-04-18
Owner Life Technologies corporation (USA)
Inventor Rhodes, Charles R.

Abstract

A filter bag assembly includes: a flexible first sheet; a flexible second sheet overlying and secured to the first sheet so that a compartment is formed therebetween; a porous filter sheet disposed between the first sheet and the second sheet so as to divide the compartment into a first compartment and a second compartment; a first port secured to the second sheet so as to communicate directly with the first compartment; and a second port secured to the second sheet so as to communicate directly with the second compartment, the second port being spaced apart from the first port. The porous filter sheet is disposed so that fluid entering the first compartment through the first port must pass through the filter sheet before entering the second compartment or exiting through the second port.

IPC Classes  ?

  • B01D 29/27 - Filter bags
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler

10.

SURFACE TREATMENT OF SEMICONDUCTOR SENSORS

      
Application Number 18475640
Status Pending
Filing Date 2023-09-27
First Publication Date 2024-04-18
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Cicero, Ronald L.
  • Ball, James A.
  • Mastroiann1, Alexander
  • Inman, Christina E.
  • Gray, Jeremy
  • Glazer, Marc
  • Wang, Yufang
  • Koscinski, Joseph
  • Waggoner, Phil

Abstract

A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.

IPC Classes  ?

  • G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

11.

SYSTEMS AND METHODS FOR DATA DISTRIBUTION

      
Application Number US2023034758
Publication Number 2024/081197
Status In Force
Filing Date 2023-10-09
Publication Date 2024-04-18
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Cole, Christopher
  • Grady, Sean

Abstract

Methods and systems for data distribution are described herein. In one aspect, a method can include receiving, by at least one worker node (WN) 110 of a plurality of WNs of a data distribution system, a job definition from a job manager, wherein the job definition comprises a set of processes to be performed on a set of data request; sending, by the WN 110 and to an extended binary access manager (BAMEx) 140, a request for the data; receiving, by the WN 110 and from the BAMEx 140, the data based on the request for the data; performing, by the WN 110, one or more processes according to the job definition; generating, by the WN 110, a set of results files comprising results of at least one of the performed one or more processes; and sending, by the WN 110, the set of results files to the BAMEx 140.

IPC Classes  ?

  • G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
  • G06F 9/54 - Interprogram communication
  • G06F 3/06 - Digital input from, or digital output to, record carriers

12.

METHODS AND COMPOSITIONS FOR MULTIPLEX PCR

      
Application Number 18506885
Status Pending
Filing Date 2023-11-10
First Publication Date 2024-04-11
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Leamon, John
  • Andersen, Mark
  • Thornton, Michael

Abstract

The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

13.

Nucleotide Reagent Solutions

      
Application Number 18545099
Status Pending
Filing Date 2023-12-19
First Publication Date 2024-04-11
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Ghadiri, Jamsheed
  • Atehortua-Khalsa, Karta

Abstract

A reagent solution includes water, a nucleotide, and tris(2-carboxyethyl)phosphine in a range of 0.5 μM to 1000 μM. The reagent solution can further include a non-ionic surfactant in an amount of 0.001% to 1% or a biocidal agent in an amount of 0.001% to 1%. The reagent solution can include salts, such as sodium chloride or magnesium sulfate.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

14.

EZDNASE

      
Serial Number 98494891
Status Pending
Filing Date 2024-04-11
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Enzymes for scientific and research purposes

15.

MULTIPLEX QPCR PANEL FOR GASTROINTESTINAL PATHOGENS

      
Application Number US2023076163
Publication Number 2024/077197
Status In Force
Filing Date 2023-10-05
Publication Date 2024-04-11
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Li, Kelly
  • Pagani, Ioanna
  • Tanner, Michael
  • Wei, Changfu
  • Pabbati, Namrata
  • Huarcaya Najarro, Elvis
  • Govoni, Gregory
  • Ingerman, Elena
  • Kenny, Daryn

Abstract

A method, composition and kit for determining the presence or absence of Salmonella sp., Shigella sp./Enteroinvasive Escherichia coli (EIEC), and Campylobacter sp. in a sample, comprising producing an amplicon by subjecting a reaction mixture including the sample and five primer pairs to reaction conditions suitable to amplify targeted nucleic acids. The five primer pairs include primer pair A that specifically hybridizes with a portion of Campylobacter coli genome, primer pair B that specifically hybridizes with a portion of Campylobacter jejuni genome, primer pair C that specifically hybridizes with a portion of Campylobacter upsaliensis genome, primer pair D that specifically hybridizes with a portion of Salmonella sp. genome, and primer pair E that specifically hybridizes with a portion of Shigella sp./EIEC genome; and determining the presence or absence of Campylobacter sp., Salmonella sp., and/or Shigella sp./Enteroinvasive Escherichia coli (EIEC) in the sample based on the amplicon.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

16.

ALUORA

      
Serial Number 98493909
Status Pending
Filing Date 2024-04-10
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Fluorescent dye for scientific or research use

17.

INNOVIGENE

      
Serial Number 98491302
Status Pending
Filing Date 2024-04-09
Owner Applied Biosystems, LLC ()
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Downloadable computer software for scientific analysis of genetic sequences

18.

Fluorogenic pH-sensitive compounds and their methods of use

      
Application Number 17498377
Grant Number 11952495
Status In Force
Filing Date 2021-10-11
First Publication Date 2024-04-09
Grant Date 2024-04-09
Owner Life Technologies Corporation (USA)
Inventor
  • Hu, Yi-Zhen
  • Chen, Aimei
  • Beacham, Daniel
  • Vonnegut, Chrisgen
  • Nacharaju, Krishnamurthy

Abstract

The present disclosure provides for compounds of Formula (I), its corresponding compounds of Formula (II) or salts thereof and their use as fluorogenic pH sensors.

IPC Classes  ?

19.

Display screen with transitional graphical user interface

      
Application Number 29835509
Grant Number D1021947
Status In Force
Filing Date 2022-04-19
First Publication Date 2024-04-09
Grant Date 2024-04-09
Owner Life Technologies Corporation (USA)
Inventor
  • Zimmerman, Sean
  • Rickes, Scott

20.

NORMALIZATION METHODS

      
Application Number US2023074789
Publication Number 2024/073291
Status In Force
Filing Date 2023-09-21
Publication Date 2024-04-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Bachir, Alexia
  • Dix, Andrew

Abstract

Methods and system are described for normalizing and creating correction factors for measurements in a fluorometer. To ensure that measurements across multiple channels can be properly compared, some kind of calibration must be done. The same calibrant can be run across all the channels and fluorescence measured. The fluorescence of one channel can be chosen as a reference. A correction factor can be calculated for each channel and used for an extended period of time, possibly even the lifetime of the instrument.

21.

DIBENZOXANTHENE QUENCHERS, USES, AND METHODS OF PREPARATION

      
Application Number 18345621
Status Pending
Filing Date 2023-06-30
First Publication Date 2024-04-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Levitz, Andrew
  • Mullah, Khairuzzaman Bashar
  • Evans, Brian
  • Benson, Scott C.
  • Vonnegut, Chris

Abstract

The present disclosure relates to dibenzoxanthene compounds that are efficient quenchers of fluorescence, for example in the far red and near infrared spectrum. Applications using the dibenzoxanthene quenching compounds and methods of making same are also described.

IPC Classes  ?

  • C09B 57/14 - Benzoxanthene dyes; Benzothioxanthene dyes
  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 29/24 - Probes

22.

ASEPTIC CELL CULTURE SYSTEM AND METHODS OF USE

      
Application Number 18474004
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-04-04
Owner Life Technologies Corporation (USA)
Inventor
  • Smith, Mark Thomas
  • Klinkenberg, David

Abstract

An aseptic cell culture system including a cell culture device is disclosed. The cell culture device includes an interior chamber having a first opening extending through a wall defining a part of the interior chamber, and a first aseptic port. The first aseptic port includes a first coupling end and a second coupling end, the first coupling end extending through the first opening and integrated with the wall. Further, the first aseptic port includes a fluid pathway in fluid communication with the interior chamber and extends between the first coupling end and the second coupling end. The second coupling end includes a connecting component configured to allow one or more of a fluid line and a filter to be connected to the first aseptic port.

IPC Classes  ?

23.

SYSTEM AND METHOD FOR GENOTYPING STRUCTURAL VARIANTS

      
Application Number US2023075334
Publication Number 2024/073544
Status In Force
Filing Date 2023-09-28
Publication Date 2024-04-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Gujjula, Krishna Reddy
  • Bai, Cheng-Zong
  • Suren, Haktan

Abstract

Methods for determining genotypes of structural variants in a sample genome, may include: amplifying nucleic acid sequences at targeted locations in the sample genome by a panel targeting a plurality of structural variant marker to generate sequence reads; mapping the sequence reads to a modified reference genome to produce aligned sequence reads, wherein the modified reference genome includes a wild-type target region and a structural variant target region; for each structural variant marker, determining a read count for a wild-type allele and a read count for a structural variant allele; determining a probability for each possible genotype, wherein the possible genotypes include a homozygous wild-type genotype, a heterozygous genotype and a homozygous structural variant genotype; and selecting the genotype with a maximum probability value to provide an estimated genotype corresponding to the structural variant marker of the sample.

IPC Classes  ?

  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

24.

Methods and Kits to Detect Viral Particle Heterogeneity

      
Application Number 18137956
Status Pending
Filing Date 2023-04-21
First Publication Date 2024-03-28
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Li, Yixin
  • Solanki, Bharti
  • Shih, Sheung-Mei
  • Bell, Peter
  • Dayne, Darick

Abstract

Provided herein are compositions, methods and uses that relate to an easy, accurate and reliable dual or duplex assay that determines both protein and nucleic acid amounts in a viral preparation in a single container and further determines full versus empty virion content.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

25.

HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS

      
Application Number 18235205
Status Pending
Filing Date 2023-08-17
First Publication Date 2024-03-28
Owner
  • Thermo Fisher Scientific GENEART GmbH (Germany)
  • LIFE TECHNOLOGIES AS (Norway)
  • LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Poehmerer, Thomas
  • Kuhn, Phillip
  • Notka, Frank
  • Zeidler, Andreas
  • Heil, Korbinian
  • Trefzer, Axel
  • Fonnum, Geir
  • Katzen, Federico
  • Andersson, Kristian
  • Liang, Xiquan

Abstract

The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B03C 5/02 - Separators
  • C25B 3/29 - Coupling reactions
  • C25B 9/70 - Assemblies comprising two or more cells
  • C25B 11/04 - Electrodes; Manufacture thereof not otherwise provided for characterised by the material
  • C25B 15/02 - Process control or regulation

26.

POLYMERASE COMPOSITIONS AND KITS, AND METHODS OF USING AND MAKING THE SAME

      
Application Number 18521466
Status Pending
Filing Date 2023-11-28
First Publication Date 2024-03-28
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Mazur, Daniel
  • Chen, Sihong
  • Vander Horn, Peter
  • Tozer, Eileen
  • Luo, Guobin
  • Shirley, Joshua
  • Heinemann, Kevin

Abstract

The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification. In some aspects, the disclosure relates to recombinant polymerases useful for the generation of nucleic acid libraries and/or nucleic acid templates.

IPC Classes  ?

  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/686 - Polymerase chain reaction [PCR]

27.

ELECTROPORATION PIPETTE, SYSTEM AND METHOD OF USE THEREOF

      
Application Number US2023032940
Publication Number 2024/064040
Status In Force
Filing Date 2023-09-15
Publication Date 2024-03-28
Owner
  • LIFE TECHNOLOGIES HOLDINGS PTE LIMITED (Singapore)
  • LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Wei, Han
  • Chan, Chee Wai
  • Liaw, Wui Khen
  • Dong, Shan Hua
  • Goh, See Chen
  • Yeo, Huei Steven
  • Sicat, Jr., Harmon Cosme
  • Ling, Mio Xiu Lu
  • Mead, Josh M.
  • Makinen, Mikko
  • Lim, Beng Heng
  • Boo, Kuan Moon
  • Bong, Justina Linkai
  • Ng, Chye Sin
  • Lee, Wee Liam
  • Lim, Li Yang
  • Lee, Way Xuang

Abstract

An electroporation system including one or more of a pipette, a pipette tip, a pipette docking assembly, and a pulse generator. The pipette docking assembly includes a pipette station, a pipette station guard, and a reservoir (e.g., a buffer tube). A method for transfecting a cell with a payload including providing an electroporation system, providing the cell, providing the payload, introducing the cell and the payload into a pipette tip, and electroporating the cell within the pipette tip by operating the electroporation system.

28.

MULTIPLEX NUCLEIC ACID AMPLIFICATION

      
Application Number 18241617
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-03-28
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Joun, David
  • Li, Chieh-Yuan
  • Reed, Brian
  • Obergfell, Craig
  • Dressman, Devin
  • Rosenbaum, Abraham
  • Benson, Scott
  • Broka, Andi
  • Ghosh, Srinka

Abstract

In some embodiments, the disclosure relates generally to compositions, comprising a single reaction mixture containing a plurality of different populations of discrete supports, and a plurality of different populations of target nucleic acids. The single reaction mixture can contain a first population of beads; a second population of beads; a first population of target nucleic acids, where at least two different target nucleic acids in the first population of target nucleic acids can bind to a bead in the first population of beads; and a second population of target nucleic acids, where at least two different target nucleic acids in the second population of target nucleic acids can bind to a bead in the second population of beads. The single reaction mixture can be employed to monoclonally amplify the first target nucleic acids on the first beads, and monoclonally amplify the second target nucleic acids on the second beads.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6844 - Nucleic acid amplification reactions

29.

OLIGONUCLEOTIDE-TETHERED NUCLEOTIDES

      
Application Number 18345856
Status Pending
Filing Date 2023-06-30
First Publication Date 2024-03-28
Owner
  • Thermo Fisher Scientific Baltics UAB (Lithuania)
  • Life Technologies Corporation (USA)
Inventor
  • Lubys, Arvydas
  • Cikotiene, Inga
  • Kapustina, Zana
  • Berezniakovas, Arturas
  • Sulgaite, Justina
  • Zeimyte, Simona
  • Andersen, Mark
  • Allen, Michael
  • Chen, Sihong

Abstract

The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligo-nucleotides can be used in a variety of nucleic acid sequencing methods.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

30.

ION AMPLISEQ

      
Serial Number 98461358
Status Pending
Filing Date 2024-03-21
Owner Life Technologies Corporation ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Diagnostic preparations for medical use

31.

ONCOPRO

      
Serial Number 98461409
Status Pending
Filing Date 2024-03-21
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Cells for scientific, laboratory or medical research

32.

METHODS FOR DETECTING ALLELE DOSAGES IN POLYPLOID ORGANISMS

      
Application Number US2023073826
Publication Number 2024/059487
Status In Force
Filing Date 2023-09-11
Publication Date 2024-03-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Gujjula, Krishna Reddy
  • Suren, Haktan
  • Bai, Cheng-Zong

Abstract

A method for determining a genotype of a sample of a polyploid organism, may include: amplifying nucleic acid sequences at targeted locations in a sample genome by a panel targeting a plurality of SNP markers to generate sequence reads; mapping the sequence reads to a reference genome for the polyploid organism; detecting variants in the aligned sequence reads to produce detected variants, wherein the detected variants include detected SNP's corresponding to the SNP markers; determining a probability for each alternate allele dosage of a plurality of possible allele dosages for a corresponding detected SNP, wherein the number of possible allele dosages is equal to a ploidy of the SNP marker plus one; and selecting the alternate allele dosage with a maximum probability value to provide an estimated allele dosage corresponding to the SNP marker, wherein the estimated allele dosage is indicative of the genotype for the SNP marker.

IPC Classes  ?

  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

33.

Systems And Methods For Improved Imaging And Fluorescence In Flow Cytometry And Other Applications

      
Application Number 18240441
Status Pending
Filing Date 2023-08-31
First Publication Date 2024-03-21
Owner Life Technologies Corporation (USA)
Inventor
  • Ward, Michael D
  • Kaduchak, Gregory
  • Strelkov, Dmitriy

Abstract

Provided are systems and methods that allow for brightfield imaging in a flow cytometer, allowing for collection of fluorescence and high-quality image date. The disclosed technology also gives rise to an illumination pattern that allows a user to create different oblique or structured illumination profiles within a static system. With the disclosed approach, a user can illuminate a sample from a first direction (e.g., with laser illumination configured to give rise to one or more of fluorescence information and scattering information), collect scattering information from a second direction, collect fluorescence information from a third direction, and capture an image of the sample from a fourth direction. (Two or more of the foregoing can be accomplished simultaneously.) Also as described elsewhere herein, an illumination used to illuminate the sample for visual image capture can be communicated to the same through a lens that also collects fluorescence from the sample.

IPC Classes  ?

34.

BIOREACTORS OPERABLE IN STATIC AND DYNAMIC MODES AND METHODS OF USE

      
Application Number US2023074211
Publication Number 2024/059721
Status In Force
Filing Date 2023-09-14
Publication Date 2024-03-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Goodwin, Michael
  • De Mollerat Du Jeu, Xavier
  • Wise, Tristan
  • Hsiao, Tony
  • Campbell, Andrew
  • Thacker, Paul
  • Derrick, Michael
  • Kaiser, Jacob

Abstract

A bioreactor pod includes a pod base; a dual mode bioreactor operable in static and dynamic modes and insertable into the pod base; one or more portable and arrangeable pod modules; a stand for mounting pod components; a display including a user interface for transmitting user inputs and receiving outputs associated with the dual mode bioreactor, pod modules; and a controller for controlling the bioreactor and pod modules.

35.

GENEXUS

      
Serial Number 98456967
Status Pending
Filing Date 2024-03-19
Owner Life Technologies Corporation ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Diagnostic preparations for medical use

36.

OPTICHO

      
Serial Number 98457224
Status Pending
Filing Date 2024-03-19
Owner Life Technologies Corporation ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Cell culture media for medical or veterinary purposes

37.

ONE SHOT

      
Serial Number 98457228
Status Pending
Filing Date 2024-03-19
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Cell culture media for scientific research use

38.

OPTICHO

      
Serial Number 98457230
Status Pending
Filing Date 2024-03-19
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Cell culture media for scientific and research use

39.

GENEXUS

      
Serial Number 98456971
Status Pending
Filing Date 2024-03-19
Owner Life Technologies Corporation ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Apparatus and instruments for clinical and medical diagnosis, namely, nucleic acid sequencers and synthesizers, genetic analyzers, and instruments for the preparation of nucleic acid samples

40.

RESDNASEQ

      
Application Number 1780279
Status Registered
Filing Date 2023-10-23
Registration Date 2023-10-23
Owner APPLIED BIOSYSTEMS, LLC (USA)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical reagents for non-medical purpose; diagnostic reagents and kits comprised of diagnostic reagents for scientific or research use.

41.

METHODS AND APPARATUS FOR MEASURING ANALYTES

      
Application Number 18324346
Status Pending
Filing Date 2023-05-26
First Publication Date 2024-03-14
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Milgrew, Mark
  • Rothberg, Jonathan
  • Bustillo, James

Abstract

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

IPC Classes  ?

  • G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
  • C12Q 1/6869 - Methods for sequencing
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe

42.

COMPOSITIONS, KITS AND METHODS FOR DETECTION OF VIRAL VARIANT SEQUENCES

      
Application Number US2023073662
Publication Number 2024/054925
Status In Force
Filing Date 2023-09-07
Publication Date 2024-03-14
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Brzoska, Pius
  • Furtado, Manohar
  • Wilde, Joyce
  • Kendrick, Sara
  • Stevens, Junko
  • Hayashibara, Kathleen
  • Varma, Kamini
  • Ulekleiv, Camilla

Abstract

Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of SARS-CoV-2, including SARS-CoV-2 variants, or other coronaviruses from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

43.

COMPOSITIONS AND METHODS FOR CULTURING AND EXPANDING CELLS

      
Application Number 18176123
Status Pending
Filing Date 2023-02-28
First Publication Date 2024-03-07
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Varela-Rohena, Angel
  • Donato, Jennifer
  • Mansour, Sarya
  • Dallas, Matthew
  • Hachmann, Anna-Barbara

Abstract

Provided herein are, inter alia, compositions, systems, kits, and methods for culturing and expanding cells (such as T cells, diploid or non-diploid cells), as well as methods for treating disorders (e.g., with T cells), and methods for producing biological molecules and compositions (e.g., proteins, viruses, viral particles or fragments thereof, etc.), including vaccines.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells

44.

NUCLEIC ACID AMPLIFICATION

      
Application Number 18221099
Status Pending
Filing Date 2023-07-12
First Publication Date 2024-02-29
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Li, Chieh-Yuan
  • Ruff, David
  • Chen, Shiaw-Min
  • O'Neil, Jennifer
  • Kasinskas, Rachel
  • Rothberg, Jonathan
  • Li, Bin
  • Lao, Kai Qin

Abstract

The present disclosure provides methods, compositions, kits and systems for nucleic acid amplification. In some embodiments, nucleic acid amplification methods include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, nucleic acid amplification methods include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the nucleic acid amplification method employs an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel and/or in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer which can include a sieving agent and/or a diffusion-reducing agent.

IPC Classes  ?

  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/686 - Polymerase chain reaction [PCR]

45.

POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME

      
Application Number 18486337
Status Pending
Filing Date 2023-10-13
First Publication Date 2024-02-29
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Vander Horn, Peter
  • Nikiforov, Theo
  • Mazur, Daniel
  • Tozer, Eileen
  • Landes, Mindy

Abstract

The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

IPC Classes  ?

  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6869 - Methods for sequencing

46.

FOAM LAYER MEASURING SYSTEM

      
Application Number US2023072755
Publication Number 2024/044645
Status In Force
Filing Date 2023-08-23
Publication Date 2024-02-29
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Smith, Mark Thomas
  • Martin, Ronald Abraham
  • Adams, Joshua Lynn

Abstract

Systems and methods for measuring a foam layer in a fluid processing system are disclosed. The system includes a container having a chamber for containing a liquid and the foam layer. The system includes a first sensor positioned adjacent a top portion of the chamber. The first sensor is configured to measure a first distance between a top foam surface of the foam layer and the first sensor. The system includes a second sensor coupled to the container, the second sensor configured to measure a mass of the liquid. The system also includes a processor configured to perform the operations of calculating a thickness of the foam layer based on dimensions of the chamber of the container, the measured first distance between the top foam surface of the foam layer and the first sensor, and the mass of the liquid as measured by the second sensor.

IPC Classes  ?

  • G01F 17/00 - Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
  • G01F 1/34 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
  • G01S 13/08 - Systems for measuring distance only
  • G01S 17/88 - Lidar systems, specially adapted for specific applications

47.

COMPRESSION COLLAR EXPANDER ASSEMBLY AND METHOD OF USE

      
Application Number US2023072858
Publication Number 2024/044715
Status In Force
Filing Date 2023-08-24
Publication Date 2024-02-29
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Moore, Michael
  • Knudsen, Brandon M.
  • Pickup, Kevin R.
  • Merritt, Dewayne S.
  • Hodges, Collin Vaughn
  • Burtenshaw, Brandon R.

Abstract

Various embodiments of a compression collar expander assembly for expanding a tubular compression collar are described. For example, the compression collar expander assembly can include a guide plate, a spindle plate, and a plurality of carriages movably disposed on a top surface of the guide plate. Each of the plurality of carriages can include a body, a guide projecting from the body, and a die set comprising a plurality of dies. Each die can include a base coupled to a corresponding one of the plurality of carriages and a prong upstanding from the base. In some embodiments, a tapered expander is configured to assist with expanding the plurality of dies.

IPC Classes  ?

  • B21D 19/00 - Flanging or other edge treatment, e.g. of tubes

48.

Modular impeller

      
Application Number 29773911
Grant Number D1016098
Status In Force
Filing Date 2021-03-12
First Publication Date 2024-02-27
Grant Date 2024-02-27
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Jones, Nephi D.
  • Brown, Jason D.

49.

ENERGY TRANSFER DYE CONJUGATES FOR USE IN BIOLOGICAL ASSAYS

      
Application Number 18006554
Status Pending
Filing Date 2021-07-23
First Publication Date 2024-02-22
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Benson, Scott
  • Menchen, Steven
  • Chang, Chu-An
  • Lee, Linda
  • Mullah, Khairuzzaman

Abstract

Energy transfer dye pairs including a donor dye covalently attached to an acceptor dye through a linker, uses of the energy transfer dye pairs, for example, in conjugates of an energy transfer dye pair covalently attached to a quencher and an analyte (e.g., an oligonucleotide), for biological applications including, for example, amplification assays such as quantitative polymerase chain reaction (qPCR) and digital PCR (dPCR).

IPC Classes  ?

  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • C09B 62/343 - Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to a five-membered ring

50.

Integrated Biocontainment Cell Sorter

      
Application Number 18240415
Status Pending
Filing Date 2023-08-31
First Publication Date 2024-02-22
Owner Life Technologies Corporation (USA)
Inventor
  • Gulley, Lincoln T
  • Fox, Daniel N
  • Goldfain, Angela L

Abstract

Disclosed is an integrated biocontainment cell sorter that isolates portions of the cell sorter that can create contamination. Two containment systems are utilized. A main cabinet containment system contains input samples. An aerosol management containment area includes a nozzle chamber with a nozzle and a sort chamber with sort plates and collection media that collect a droplet stream from the nozzle. The main cabinet is maintained at a first low pressure and clean air is recirculated under a positive pressure. The aerosol management containment area is kept at a second low pressure, which is lower than the first pressure, so that contamination does not leak from the aerosol management containment area into the main cabinet containment area. A sliding sash window is located over an access opening in the main cabinet and can be moved to access different portions of the main cabinet without changing the substantially constant first low pressure in the main cabinet.

IPC Classes  ?

  • G01N 15/14 - Electro-optical investigation
  • G01N 1/22 - Devices for withdrawing samples in the gaseous state

51.

CLEARAMIDE

      
Serial Number 98403590
Status Pending
Filing Date 2024-02-13
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical reagents, other than for medical or veterinary purpose; Fluorescent dye for scientific or research use

52.

COMPOSITIONS AND METHODS FOR ENHANCED FLUORESCENCE

      
Application Number 18380388
Status Pending
Filing Date 2023-10-16
First Publication Date 2024-02-08
Owner
  • Life Technologies Corporation (USA)
  • Pierce Biotechnology, Inc. (USA)
Inventor
  • Desai, Surbhi
  • Nlend, Marie Christine
  • Gee, Kyle
  • Baker, Matthew
  • Aggeler, Robert
  • Sweeney, Scott
  • Rukavishnikov, Aleksey
  • Huang, Shih-Jung

Abstract

This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.

IPC Classes  ?

  • A61K 49/00 - Preparations for testing in vivo
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
  • A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
  • G01N 33/533 - Production of labelled immunochemicals with fluorescent label
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

53.

Compression Collars for Coupling a Tube to a Tube Fitting

      
Application Number 18485155
Status Pending
Filing Date 2023-10-11
First Publication Date 2024-02-08
Owner Life Technologies Corporation (USA)
Inventor
  • Beus, Ryan S.
  • Burtenshaw, Brandon R.
  • Davis, Eric
  • Draper, Patrick L.
  • Goodwin, Michael E.
  • Knudsen, Brandon M.
  • Larsen, Jeremy K.
  • Pickup, Kevin R.

Abstract

A coupling assembly includes: a tubular compression collar having a tubular body made of a resiliently flexible polymeric material and having an interior surface and an opposing exterior surface; an end of a tube disposed within a throughway of the compression collar; and a tube fitting disposed within the passageway of the tube. The tube fitting includes: a tubular stem; a flange radially outwardly projecting from an exterior surface of the stem; and an annular barb encircling and radially outwardly projecting from the exterior surface of the stem, the annular barb including a frustoconical outside face that extends along and outwardly slopes away from the stem as the outside face extends toward the flange. The compression collar radially inwardly compresses the tube against the annular barb of the tube fitting so that a liquid tight seal is formed between the tube and the tube fitting.

IPC Classes  ?

  • F16L 33/207 - Undivided rings, sleeves, or like members contracted on the hose or expanded inside the hose by means of tools; Arrangements using such members only a sleeve being contracted on the hose
  • F16L 33/22 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts
  • B29C 65/00 - Joining of preformed parts; Apparatus therefor
  • B29C 65/68 - Joining of preformed parts; Apparatus therefor by liberation of internal stresses, e.g. shrinking of one of the parts to be joined using auxiliary shrinkable element
  • B29C 65/56 - Joining of preformed parts; Apparatus therefor using mechanical means
  • A61M 39/12 - Tube connectors or tube couplings for joining a flexible tube to a rigid attachment

54.

LIPIDS FOR NUCLEIC ACID DELIVERY

      
Application Number US2023071670
Publication Number 2024/031051
Status In Force
Filing Date 2023-08-04
Publication Date 2024-02-08
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Boudif, Arezki
  • Parayath, Neha Nitin

Abstract

Provided herein are ionizable lipids, compositions comprising the ionizable lipids, and methods of making and using the same. The ionizable lipids provided herein can be formulated in lipid compositions for the delivery of macromolecules, such as nucleic acids, in vitro, ex vivo, or in vivo.

IPC Classes  ?

  • C07D 265/30 - 1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
  • C07D 279/12 - 1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
  • C07D 295/145 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

55.

COMPOSITIONS, KITS, AND METHODS FOR DETECTION OF VARIANT STRAINS OF AFRICAN SWINE FEVER VIRUS

      
Application Number US2023029005
Publication Number 2024/030345
Status In Force
Filing Date 2023-07-28
Publication Date 2024-02-08
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Martin, Elise
  • Moine, Sandrine
  • Blanc, Aurore

Abstract

Disclosed are compositions, methods, systems, and kits for the detection of African swine fever virus (ASFV) in a test sample, and in particular for distinguishing between wild/reference type ASFV and mutant/variant strains of ASFV. A variant ASFV assay includes a first set of primers and a first probe that correspond to a first ASFV target, and a second set of primers and a second probe that correspond to a second ASFV target. The first and second probes are differentially labelled. The first ASFV target is a MGF360 gene and the second ASFV target is the CD2v gene. Absence of these targets, in conjunction with a positive determination for another generic ASFV target such as the p72 gene, is indicative of a vaccine-associated variant strain of ASFV.

IPC Classes  ?

  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

56.

Chemically Defined Serum Albumin Substitutes

      
Application Number 18257534
Status Pending
Filing Date 2021-12-15
First Publication Date 2024-02-08
Owner Life Technologies Corporation (USA)
Inventor
  • Jessee, Joel
  • Kuninger, David
  • Shin, Soojung

Abstract

Provided herein, inter alia, are chemically defined components and compositions that substitute or partially substitute for albumin in cell culture media. The components and compositions may support cell cultures, protect cells, or enhance viability of cultured cells. Further provided are chemically defined culture media supplements for use in cell culture media containing albumin. The chemically defined culture media supplements may rescue cells from albumin-induced toxicity.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
  • C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

57.

CRYODOT

      
Serial Number 98394258
Status Pending
Filing Date 2024-02-06
Owner Molecular Probes, Inc. ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Kit for detection and quantitation of cell viability comprising fluorescent dyes

58.

Methods of Using Compression Collars for Coupling a Tube to a Tube Fitting

      
Application Number 18486070
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-02-01
Owner Life Technologies Corporation (USA)
Inventor
  • Beus, Ryan S.
  • Burtenshaw, Brandon R.
  • Davis, Eric
  • Draper, Patrick L.
  • Goodwin, Michael E.
  • Knudsen, Brandon M.
  • Larsen, Jeremy K.
  • Pickup, Kevin R.

Abstract

A method for coupling a tube to a tube fitting includes radially outwardly expanding a tubular compression collar from a constricted state to an expanded state, the compression collar having a throughway extending there through and being made of a resiliently flexible material. An end of the tube is inserted within the throughway of the expanded compression collar, the tube bounding a passage. A tube fitting is inserted within the passage of the tube. The compression collar is allowed to resiliently rebound back towards the constricted state so that the compression collar pushes the tube against the tube fitting.

IPC Classes  ?

  • F16L 33/207 - Undivided rings, sleeves, or like members contracted on the hose or expanded inside the hose by means of tools; Arrangements using such members only a sleeve being contracted on the hose
  • F16L 33/22 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts
  • B29C 65/00 - Joining of preformed parts; Apparatus therefor
  • B29C 65/68 - Joining of preformed parts; Apparatus therefor by liberation of internal stresses, e.g. shrinking of one of the parts to be joined using auxiliary shrinkable element
  • B29C 65/56 - Joining of preformed parts; Apparatus therefor using mechanical means
  • A61M 39/12 - Tube connectors or tube couplings for joining a flexible tube to a rigid attachment

59.

CYCLE THRESHOLDS IN MACHINE LEARNING FOR FORECASTING INFECTION COUNTS

      
Application Number US2023028420
Publication Number 2024/025810
Status In Force
Filing Date 2023-07-21
Publication Date 2024-02-01
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Sharmin, Mahfuza
  • Manivannan, Manimozhi
  • Woo, David
  • Mujawar, Imran
  • Gandhi, Manoj

Abstract

Methods for forecasting case counts for a future date in one or more geographic areas of persons infected by a disease is disclosed. The presence of the disease in a biological sample is testable by a polymerase chain reaction (PCR) test. A load of one or more pathogens associated with the disease correlates with a PCR cycle which indicates presence of the one or more pathogens, and is referred to as a threshold cycle (Ct). Data relevant to forecasting the case counts including Ct data and other data is received. The Ct data comprises Ct values from PCR tests of biological samples from persons within the one or more geographic areas. Arrays of feature data for processing by a trained machine learning model are generated, comprising Ct features and other features obtained from the data. A forecasted number of infected persons are generated by processing the arrays using machine learning.

IPC Classes  ?

  • G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
  • G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu

60.

METHODS AND SYSTEMS TO DETECT LARGE REARRANGEMENTS IN BRCA1/2

      
Application Number 18366912
Status Pending
Filing Date 2023-08-08
First Publication Date 2024-02-01
Owner Life Technologies Corporation (USA)
Inventor
  • Scafe, Charles
  • Brinza, Dumitru
  • Veitch, James
  • Qi, Rongsu
  • Hyland, Fiona

Abstract

A method for detecting large rearrangements in BRCA1 and BRCA2 genes includes amplifying a nucleic acid sample in the presence of a primer pool to produce amplicons, where the primer pool includes target specific primers targeting regions of exons of the BRCA1 and BRCA2 genes. The method further includes sequencing the amplicons to generate a plurality of reads, mapping the reads to a reference sequence, determining a number of reads per amplicon for the amplicons associated with the exons of the BRCA and the BRCA2 genes, determining exon copy numbers for the exons of the BRCA1 and BRCA2 genes based on the number of reads per amplicon, detecting an exon deletion or duplication based on the exon copy numbers, and detecting a whole gene deletion of the BRCA1 or BRCA2 gene based on the number of reads per amplicon associated with the exons of the BRCA1 and BRCA2 genes.

IPC Classes  ?

  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16B 20/10 - Ploidy or copy number detection
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6869 - Methods for sequencing

61.

Display screen with graphical user interface

      
Application Number 29800887
Grant Number D1012960
Status In Force
Filing Date 2021-07-23
First Publication Date 2024-01-30
Grant Date 2024-01-30
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Hicks, Justin
  • Shallice, Matthew
  • Stone, Laurel
  • Archer, Charysse

62.

MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS

      
Application Number 18306419
Status Pending
Filing Date 2023-04-25
First Publication Date 2024-01-25
Owner Life Technologies Corporation (USA)
Inventor Rearick, Todd

Abstract

A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity of one or more neighboring reaction confinement regions that may or may not be loaded; receiving output signals from the reactor array; and modeling a background signal for the loaded reaction confinement region using the received output signals and a model adapted to account at least for an exchange of ions between the one or more neighboring reaction confinement regions and a headspace adjacent the loaded reaction confinement region and the one or more neighboring reaction confinement regions.

IPC Classes  ?

  • G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • G16B 25/00 - ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

63.

TEMPERATURE INSULATED PACKAGING SYSTEMS AND RELATED METHODS

      
Application Number 18447449
Status Pending
Filing Date 2023-08-10
First Publication Date 2024-01-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Madanagopal, Arunkumar
  • Barnitz, Eric

Abstract

A temperature insulated packaging system includes a container having interior surface bounding an interior volume and a liner disposed within the interior volume and at least partially bounding a compartment configured to receive an item for temperature insulated shipping. The liner includes a first sleeve made of cellulose material and at least partially bounds a channel. The first sleeve has an outside wall disposed adjacent to the container and an opposing inside wall disposed adjacent to the compartment configured to receive the item for shipping, the channel being disposed between the inside wall and the outside wall. At least one insulation sheet is disposed within the channel of the first sleeve, the at least one insulation sheet being made of a cellulose material and having a plurality of recesses formed thereon.

IPC Classes  ?

  • B65D 81/38 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
  • B65D 5/56 - Linings or internal coatings
  • B65D 5/66 - Hinged lids
  • B65D 65/46 - Applications of disintegrable, dissolvable or edible materials

64.

HIGH SEQUENCE FIDELITY NUCLEIC ACID SYNTHESIS AND ASSEMBLY

      
Application Number 17909091
Status Pending
Filing Date 2021-03-05
First Publication Date 2024-01-25
Owner
  • LIFE TECHNOLOGIES CORPORATION (USA)
  • THERMO FISHER SCIENTIFIC GENEART GMBH (Germany)
Inventor
  • Potter, Robert
  • Netuschil, Nikolai

Abstract

The present disclosure generally relates to compositions and methods for the synthesis of nucleic acid molecules with low error rates. Provided, as examples, are compositions and methods for high throughput synthesis and assembly of nucleic acid molecules, in many instances, with high sequence fidelity. In many instances, thermostable mismatch recognition proteins (e.g., thermostable mismatch binding protein, thermostable mismatch endonucleases) will be present in compositions and use methods provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12N 9/22 - Ribonucleases

65.

Cycle Thresholds in Machine Learning for Forecasting Infection Counts

      
Application Number 18225065
Status Pending
Filing Date 2023-07-21
First Publication Date 2024-01-25
Owner Life Technologies Corporation (USA)
Inventor
  • Sharmin, Mahfuza
  • Manivannan, Manimozhi
  • Woo, David
  • Mujawar, Imran
  • Gandhi, Manoj

Abstract

Methods for forecasting case counts for a future date in one or more geographic areas of persons infected by a disease is disclosed. The presence of the disease in a biological sample is testable by a polymerase chain reaction (PCR) test. A load of one or more pathogens associated with the disease correlates with a PCR cycle which indicates presence of the one or more pathogens, and is referred to as a threshold cycle (Ct). Data relevant to forecasting the case counts including Ct data and other data is received. The Ct data comprises Ct values from PCR tests of biological samples from persons within the one or more geographic areas. Arrays of feature data for processing by a trained machine learning model are generated, comprising Ct features and other features obtained from the data. A forecasted number of infected persons are generated by processing the arrays using machine learning.

IPC Classes  ?

  • G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • C12Q 1/686 - Polymerase chain reaction [PCR]

66.

MULTI-COLUMN CHROMATOGRAPHY SYSTEMS WITH ROTATABLE VALVE ASSEMBLIES

      
Application Number 18256913
Status Pending
Filing Date 2021-12-08
First Publication Date 2024-01-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor Greenwood, John Paul

Abstract

A chromatography system includes a first chromatography column and a panel having a top face and an opposing bottom face, a first cavity being formed on the panel so as to pass through the top face and be encircled by an inner surface. The panel bounds an inlet fluid channel having an end terminating at an inlet opening formed on the inner surface encircling the first cavity so that the inlet fluid channel communicates with the first cavity. The panel also bounds a plurality of first outlet fluid channels each having an end terminating at an outlet opening formed on the inner surface encircling the first cavity so that each of the plurality of first outlet fluid channels communicate with the first cavity, a first one of the plurality of first outlet fluid channels being in fluid communication with the first chromatography column. A first valve is rotatably disposed within the first cavity.

IPC Classes  ?

  • B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
  • B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus

67.

FOAM BREAKER DEVICE AND METHODS OF USE

      
Application Number US2023027924
Publication Number 2024/019981
Status In Force
Filing Date 2023-07-17
Publication Date 2024-01-25
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Brown, Jason, D.
  • Jones, Nephi, D.

Abstract

Described herein are various methods and embodiments of a fluid processing system and foam breaker devices for at least reducing foam formation in a container of the fluid processing system. In some embodiments, the foam breaker device includes a mounting hub extending along a longitudinal axis of the foam breaker device. The mounting hub can include a coupling feature for coupling the foam breaker device to a drive shaft of the fluid processing system. The foam breaker device can also include a wall structure extending circumferentially from the mounting hub at an angle relative to the longitudinal axis of the foam breaker device. The wall structure can cause a reduction in the foam volume as a result of at least a part of the wall structure contacting the foam volume.

IPC Classes  ?

  • B01D 19/02 - Foam dispersion or prevention
  • B01D 19/00 - Degasification of liquids
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • B01D 45/00 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces
  • B01F 27/90 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms

68.

PARTICLES

      
Application Number EP2023070373
Publication Number 2024/018084
Status In Force
Filing Date 2023-07-21
Publication Date 2024-01-25
Owner LIFE TECHNOLOGIES AS (Norway)
Inventor
  • Johansen, Maren
  • Paulsen, Jan
  • Firth, Daniel
  • Gokmen, Talha
  • Fonnum, Geir

Abstract

Particles This invention relates to magnetic clusters comprising nanocrystals of iron oxide. The magnetic clusters comprise an aromatic carboxylic acid and/or the magnetic clusters are monodisperse. The magnetic clusters may be useful in biological assays and other applications. The invention also relates to processes for preparing such magnetic clusters and methods of using the magnetic clusters, as well kits comprising the magnetic clusters.

IPC Classes  ?

  • H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties

69.

SYSTEMS AND METHODS FOR IDENTIFYING SEQUENCE VARIATION

      
Application Number 18330737
Status Pending
Filing Date 2023-06-07
First Publication Date 2024-01-18
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Hyland, Fiona
  • Tsung, Eric
  • Tadigotla, Vasisht
  • Zhang, Zheng
  • Brinza, Dumitru
  • Sakarya, Onur
  • Xu, Xing

Abstract

Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position.

IPC Classes  ?

  • G16B 30/10 - Sequence alignment; Homology search
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

70.

GOPURE

      
Serial Number 98360825
Status Pending
Filing Date 2024-01-17
Owner Applied Biosystems, LLC ()
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

(Based on Use in Commerce) Chromatography columns for laboratory use; chromatography columns for the development and manufacturing of biologics; (Based on Intent To Use) ; Plastic laboratory consumables, namely 96-well plates

71.

BIOTIN DERIVATIVES

      
Application Number 18349609
Status Pending
Filing Date 2023-07-10
First Publication Date 2024-01-11
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Ying, Lai-Qiang
  • Yue, Stephen
  • Branchaud, Bruce
  • Zhang, Yu-Zhong

Abstract

Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

IPC Classes  ?

  • C07D 495/04 - Ortho-condensed systems
  • C08B 37/00 - Preparation of polysaccharides not provided for in groups ; Derivatives thereof
  • G01N 33/532 - Production of labelled immunochemicals
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/554 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07K 1/13 - Labelling of peptides
  • C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
  • C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)
  • C09B 11/24 - Phthaleins containing amino groups
  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • G01N 33/533 - Production of labelled immunochemicals with fluorescent label
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

72.

Saliva collection device

      
Application Number 29770074
Grant Number D1010851
Status In Force
Filing Date 2021-02-09
First Publication Date 2024-01-09
Grant Date 2024-01-09
Owner Life Technologies Corporation (USA)
Inventor
  • Jaffe, Syrus
  • Cheng, Angie
  • Michelhaugh, Scott

73.

ENZYMATIC LIGATION OF NUCLEIC ACIDS

      
Application Number 18303828
Status Pending
Filing Date 2023-04-20
First Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Hendricks, Stephen
  • King, David J.

Abstract

Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

IPC Classes  ?

  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • A61J 1/06 - Ampoules or cartridges
  • A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes - Details; Accessories therefor
  • B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
  • B65B 31/04 - Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
  • B65D 8/00 - Containers having a curved cross-section formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of metal, plastics, wood or substitutes therefor
  • C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

74.

Lipid Compositions For In Vivo Delivery

      
Application Number 18344694
Status Pending
Filing Date 2023-06-29
First Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Verovskaya, Evgenia
  • Jessee, Joel

Abstract

Provided herein, are compositions, methods and kits for inducing an immune response in a subject. In aspects, a lipid composition is described, which includes at least one ionizable lipid comprising a charge (N), at least one peptide, and a nucleic acid molecule comprising a charge (P). In aspects, methods are provided for delivery of a payload to an immune cell using a lipid composition comprising at least one ionizable lipid, at least one endosomal release peptide, and a payload.

IPC Classes  ?

  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
  • A61K 9/127 - Liposomes
  • A61K 39/145 - Orthomyxoviridae, e.g. influenza virus

75.

MULTIPLEX PANEL FOR UPPER RESPIRATORY PATHOGENS

      
Application Number US2023069277
Publication Number 2024/006845
Status In Force
Filing Date 2023-06-28
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Hu, Fangqi
  • Wong, Linda
  • Norman, Kara

Abstract

An in vitro method, composition and kit for determining the presence or absence of adenovirus, metapneumovirus, rhinovirus/enterovirus, and parainfluenza in a sample, including providing a reaction mixture containing the sample and at least one primer pair set. The primer pair set includes at least one primer pair A that specifically amplifies a portion of adenovirus genome; at least one primer pair B that specifically amplifies a portion of metapneumovirus genome; at least one primer pair C that specifically amplifies a portion of rhinovirus/enterovirus genome; and at least one primer pair D that specifically amplifies a portion of parainfluenza genome. The reaction mixture is subjected to reaction conditions suitable to amplify targeted nucleic acids, thereby generating at least one amplicon; wherein the presence or absence of at least one amplicon in the sample indicates the presence or absence of adenovirus, metapneumovirus, rhinovirus/enterovirus, and/or parainfluenza in the sample.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

76.

METHODS FOR ASSESSING GENOMIC INSTABILITY

      
Application Number US2023069327
Publication Number 2024/006878
Status In Force
Filing Date 2023-06-29
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor Gupta, Mohit

Abstract

Methods for assessing genomic instability (GI) may include selectively amplifying nucleic acid sequences at targeted locations in a tumor sample genome by a targeted panel with a low sample input to generate a plurality of nucleic acid sequence reads; dividing the genome into segments having homogeneous copy numbers using log odds of heterozygous SNPs and CNV log ratios determined for the nucleic acid sequence reads; applying a threshold count to squared allelic log odds of each segment in autosomes of the genome to identify unbalanced copy number (UCN) segments; adding numbers of bases in the UCN segments to produce a sum of UCN bases; and dividing the sum of UCN bases by the total number of bases in all the segments identified in the autosomes of the sample genome to produce a ratio indicative of genomic instability. The ratio may be expressed as a percent to give a GI score.

IPC Classes  ?

  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G16B 20/10 - Ploidy or copy number detection

77.

COMPOSITIONS, KITS, AND METHODS FOR DETECTING NUCLEIC ACIDS USING INTRA-CHANNEL MULTIPLEXING

      
Application Number US2023069407
Publication Number 2024/006927
Status In Force
Filing Date 2023-06-29
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Shannon, Mark, E.
  • Gjerstad, Carmen
  • Leong, Harrison, M.
  • Zahedi, Mohammad Mehdi
  • Evans, Brian, J.
  • Mullah, Khairuzzaman Bashar

Abstract

Disclosed are compositions, kits, and methods that enable intra-channel multiplexing by enabling determination of separate detectable signals, each associated with a different assay target, within the same detection channel. The multiple detectable signals can be separately resolved and independently analyzed to enable detection and/or quantification of each respective target. Enabling multiple targets to be assayed within the same detection channel increases the plexy of multiplex assays without relying on additional dyes and concomitant issues of increased spectral overlap.

IPC Classes  ?

  • C12Q 1/6816 - Hybridisation assays characterised by the detection means
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C09B 11/24 - Phthaleins containing amino groups

78.

LIPID COMPOSITIONS FOR IN VIVO DELIVERY

      
Application Number US2023069418
Publication Number 2024/006937
Status In Force
Filing Date 2023-06-29
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Verovskaya, Evgenia
  • Jessee, Joel

Abstract

Provided herein, are compositions, methods and kits for inducing an immune response in a subject. In aspects, a lipid composition is described, which includes at least one ionizable lipid comprising a charge (N), at least one peptide, and a nucleic acid molecule comprising a charge (P). In aspects, methods are provided for delivery of a payload to an immune cell using a lipid composition comprising at least one ionizable lipid, at least one endosomal release peptide, and a payload.

IPC Classes  ?

  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
  • A61K 9/127 - Liposomes

79.

SYSTEMS AND METHODS FOR ANNOTATING BIOMOLECULE DATA

      
Application Number 18338499
Status Pending
Filing Date 2023-06-21
First Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Popescu, Liviu
  • Hyland, Flona

Abstract

Systems, methods, software and computer-usable media for annotating biomolecule-related data are disclosed. In certain exemplified embodiments, the biomolecules can be nucleic acids and the data can be sequence-related data. In various embodiments, systems can include one or more public or private biological attributes (e.g., annotation information databases, data storage devices and systems, etc.) sources, one or more genomic features data sources (e.g., genomic variant tools, genomic variant databases, genomic variant data storage devices and systems, etc.), a computing device (e.g., workstation, server, personal computer, mobile device, etc.) hosting an annotations module and/or a reporting module, and a client terminal.

IPC Classes  ?

  • G06F 16/2457 - Query processing with adaptation to user needs
  • G06F 16/248 - Presentation of query results
  • G06F 16/2455 - Query execution
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
  • G16B 50/10 - Ontologies; Annotations

80.

METHODS FOR ASSESSING GENOMIC INSTABILITY

      
Application Number 18343857
Status Pending
Filing Date 2023-06-29
First Publication Date 2024-01-04
Owner Life Technologies Corporation (USA)
Inventor Gupta, Mohit

Abstract

Methods for assessing genomic instability (GI) may include selectively amplifying nucleic acid sequences at targeted locations in a tumor sample genome by a targeted panel with a low sample input to generate a plurality of nucleic acid sequence reads; dividing the genome into segments having homogeneous copy numbers using log odds of heterozygous SNPs and CNV log ratios determined for the nucleic acid sequence reads; applying a threshold count to squared allelic log odds of each segment in autosomes of the genome to identify unbalanced copy number (UCN) segments; adding numbers of bases in the UCN segments to produce a sum of UCN bases; and dividing the sum of UCN bases by the total number of bases in all the segments identified in the autosomes of the sample genome to produce a ratio indicative of genomic instability. The ratio may be expressed as a percent to give a GI score.

IPC Classes  ?

  • G16B 20/10 - Ploidy or copy number detection
  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

81.

SYSTEMS AND METHODS FOR ANALYTE DETECTION FROM MULTIPLEXED ASSAYS

      
Application Number US2023069402
Publication Number 2024/006924
Status In Force
Filing Date 2023-06-29
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Shannon, Mark, E.
  • Gjerstad, Carmen
  • Leong, Harrison, M.

Abstract

Systems and methods that enable analyte detection in a multiplexed amplification process can include obtaining, at multiple time points during the amplification process, composite emission signal data associated with a composite emission signal from at least a first probe type comprising a first label configured to generate a first emission signal and a second probe type comprising a second label configured to generate a second emission signal which has spectrally similar characteristics as said first emission signal, the first probe type and the second probe type differing in thermal and/or temporal properties; and determining, based at least partially on the composite emission signal data, emission signal data associated with a emission signal from a given probe type of the first probe type or the second probe type during the amplification process.

IPC Classes  ?

  • C12Q 1/6816 - Hybridisation assays characterised by the detection means
  • G16B 25/20 - Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation

82.

MULTIPLEX DYE COMPOUNDS

      
Application Number US2023026642
Publication Number 2024/006477
Status In Force
Filing Date 2023-06-29
Publication Date 2024-01-04
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Mullah, Khairuzzaman, Bashar
  • Zahedi, Mohammad, Mehdi
  • Evans, Brian
  • Shannon, Mark, E.
  • Gjerstad, Carmen
  • Leong, Harrison, M.

Abstract

inter aliainter alia, are multiplex dye compounds and methods of use thereof.

IPC Classes  ?

  • C09B 11/24 - Phthaleins containing amino groups
  • C12Q 1/6816 - Hybridisation assays characterised by the detection means
  • C12Q 1/686 - Polymerase chain reaction [PCR]

83.

Cell counter display screen with graphical user interface

      
Application Number 29887889
Grant Number D1009922
Status In Force
Filing Date 2023-03-24
First Publication Date 2024-01-02
Grant Date 2024-01-02
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Stone, Laurel
  • Zink, Emily
  • Zimmerman, Sean
  • Diliani, Nicholas

84.

Apparatuses, Systems And Methods For Imaging Flow Cytometry

      
Application Number 18463429
Status Pending
Filing Date 2023-09-08
First Publication Date 2023-12-28
Owner Life Technologies Corporation (USA)
Inventor
  • Kaduchak, Gregory
  • Ward, Michael

Abstract

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

IPC Classes  ?

  • G01N 15/14 - Electro-optical investigation
  • G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01J 3/44 - Raman spectrometry; Scattering spectrometry
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

85.

BIOLOGICAL ANALYSIS DEVICES AND SYSTEMS

      
Application Number 18308177
Status Pending
Filing Date 2023-04-27
First Publication Date 2023-12-28
Owner
  • LIFE TECHNOLOGIES HOLDINGS PTE LIMITED (Singapore)
  • LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Chen, Ming Song
  • Chong, Chee Woei
  • Loh, Wuh Ken
  • Foo, Wern Yuh
  • Boo, Kuan Moon
  • Leclerc, Norbert
  • Uhlendorf, Kristina
  • Koellner, Reiner
  • Fuchs, Torsten
  • Breitfelder, Stefan

Abstract

A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

IPC Classes  ?

86.

COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE MONITORING

      
Application Number 18317484
Status Pending
Filing Date 2023-05-15
First Publication Date 2023-12-28
Owner Life Technologies Corporation (USA)
Inventor
  • Lowman, Geoffrey
  • Yang, Chenchen
  • Looney, Timothy

Abstract

The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor heavy and light chains in a single assay, with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

87.

Apparatuses, Systems And Methods For Imaging Flow Cytometry

      
Application Number 18463411
Status Pending
Filing Date 2023-09-08
First Publication Date 2023-12-28
Owner Life Technologies Corporation (USA)
Inventor
  • Kaduchak, Gregory
  • Ward, Michael

Abstract

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

IPC Classes  ?

  • G01N 15/14 - Electro-optical investigation
  • G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01J 3/44 - Raman spectrometry; Scattering spectrometry
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

88.

METHODS AND APPARATUS FOR PROCESSING FLUIDS

      
Application Number 18465923
Status Pending
Filing Date 2023-09-12
First Publication Date 2023-12-28
Owner Life Technologies Corporation (USA)
Inventor
  • Goodwin, Michael E.
  • Lee, Jacob D.
  • Woods, Whitt F.
  • Draper, Patrick L.

Abstract

A method for processing a fluid includes removably securing a retention member to a vessel that bounds a chamber; inserting a collapsible bag within the chamber of the vessel; securing the bag to the retention member so that the bag is supported within the chamber of the vessel; and dispensing a fluid into a compartment of the collapsible bag supported within the chamber of the vessel. The fluid can be mixed within bag while the bag is disposed within the vessel.

IPC Classes  ?

  • B01F 27/88 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with a separate receptacle-stirrer unit that is adapted to be coupled to a drive mechanism
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • B01F 23/233 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
  • B01F 23/231 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
  • B01F 27/91 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
  • B01F 27/213 - Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts characterised by the connection with the drive
  • B01F 27/2121 - Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts composed of interconnected parts
  • B01F 33/00 - Other mixers; Mixing plants; Combinations of mixers
  • B01F 33/501 - Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
  • B01F 35/41 - Mounting or supporting stirrer shafts or stirrer units on receptacles
  • B01F 35/45 - Closures or doors specially adapted for mixing receptacles; Operating mechanisms therefor
  • B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
  • B65B 1/02 - Machines characterised by the incorporation of means for making the containers or receptacles

89.

AB ASCEND

      
Serial Number 98327878
Status Pending
Filing Date 2023-12-22
Owner Applied Biosystems, LLC ()
NICE Classes  ? 37 - Construction and mining; installation and repair services

Goods & Services

Repair or maintenance of laboratory apparatus and instruments

90.

CENTRIFUGAL SEPARATORS AND SKID FOR SEPARATING BIOCOMPONENTS AND METHODS OF USE

      
Application Number 18253350
Status Pending
Filing Date 2021-11-19
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES CORPORAION (USA)
Inventor
  • Smith, Mark T.
  • Loveless, Joe
  • Ballhause, Norman
  • Lee, Jacob D.

Abstract

A skid (700) for use in separating biocomponents includes a housing (701) bounding a compartment (708), the compartment being partially bounding by a mounting platform (709); and a loading assembly (800) secured to the housing so as to communicate with the compartment. The loading assembly (800) includes an alignment plate (808) having a top surface with cavity (814) recessed therein, the cavity communicating with the compartment; a drive rotor (15) rotatably disposed below the alignment plate and at least partially encircling the cavity, the drive rotor including one or more magnets; a motor (169) coupled to the drive rotor for selectively rotating the drive rotor about the cavity; and a mount at least partially encircling the drive rotor and communicating with the compartment, the mount including a mounting plate having one or more mounting elements upstanding therefrom, the mount being movable between a raised position wherein the mounting plate is aligned with the alignment plate and a second lowered position wherein the mounting plate is disposed at an elevation lower than the alignment plate.

IPC Classes  ?

  • B04B 15/00 - Other accessories for centrifuges
  • B04B 9/02 - Electric motor drives
  • B04B 7/02 - Casings; Lids
  • B04B 5/04 - Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
  • B04B 9/12 - Suspending rotary bowls
  • C12M 1/00 - Apparatus for enzymology or microbiology

91.

METHODS FOR DEEP ARTIFICIAL NEURAL NETWORKS FOR SIGNAL ERROR CORRECTION

      
Application Number 18143828
Status Pending
Filing Date 2023-05-05
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Bai, Cheng-Zong
  • Ingerman, Eugene
  • Wang, Chao
  • Lai, Alison
  • Puschitz, Werner

Abstract

A method for labeling sequence reads includes retrieving a sequence read having an associated flow measurement and an associated flow order; matching a sequence selected from a plurality of sequences with the sequence read, the sequence having a position within the sequence that has more than one acceptable variants; determining which variant of the more than one acceptable variants matches the sequence; generating a predicted flow measurement based on the matched sequence, the variant, and a flow order; and labeling the sequence read and associated flow measurement with the predicted flow measurement.

IPC Classes  ?

  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G06N 3/0464 - Convolutional networks [CNN, ConvNet]
  • G06N 3/09 - Supervised learning
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 40/20 - Supervised data analysis

92.

Conjugated Polymeric Particle and Method of Making Same

      
Application Number 18209766
Status Pending
Filing Date 2023-06-14
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Menchen, Steven M.
  • Blanchard, Alan
  • Andruzzi, Luisa
  • Khan, Shaheer
  • Gremyachinskiy, Dmitriy
  • Lui, Alfred
  • Stolarczyk, Craig
  • Sokolsky, Tanya
  • Thwar, Prasanna Krishnan

Abstract

A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.

IPC Classes  ?

  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
  • C08F 8/40 - Introducing phosphorus atoms or phosphorus-containing groups

93.

LABORATORY AUTOMATION USING LABWARE MOVEMENT

      
Application Number 18209980
Status Pending
Filing Date 2023-06-14
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Mckinley, Keith
  • Padilla, Godfrey
  • Daschel, James
  • Noyola Lozano, Ricardo
  • Godinez, Ivan
  • Laferty, William

Abstract

A system facilitating parallel laboratory operations which includes a plurality of labware components, and a plurality of processing heads configured to interact with the plurality of labware components is described. The system further includes a first set of actuators coupled to the plurality of processing heads and configured to actuate the plurality of processing heads along a first directional axis. The system further includes a second set of actuators configured to translate the plurality of labware components along at least a second directional axis and a third directional axis. The second set of actuators may include one or more magnetic levitation systems configured to cause movement of the plurality of labware components along the second directional axis and the third directional axis.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 9/06 - Test-tube stands; Test-tube holders
  • B01L 3/02 - Burettes; Pipettes

94.

SYSTEMS AND METHODS FOR SEQUENCE DATA ALIGNMENT QUALITY ASSESSMENT

      
Application Number 18338488
Status Pending
Filing Date 2023-06-21
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Zhang, Zheng
  • Utiramerur, Sowmi
  • Hyland, Fiona

Abstract

A computer-implemented method for classifying alignments of paired nucleic acid sequence reads is disclosed. A plurality of paired nucleic acid sequence reads is received, wherein each read is comprised of a first tag and a second tag separated by an insert region. Potential alignments for the first and second tags of each read to a reference sequence is determined, wherein the potential alignments satisfies a minimum threshold mismatch constraint. Potential paired alignments of the first and second tags of each read are identified, wherein a distance between the first and second tags of each potential paired alignment is within an estimated insert size range. An alignment score is calculated for each potential paired alignment based on a distance between the first and second tags and a total number of mismatches for each tag.

IPC Classes  ?

  • G16B 30/10 - Sequence alignment; Homology search
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 30/20 - Sequence assembly
  • G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks
  • G06N 3/126 - Evolutionary algorithms, e.g. genetic algorithms or genetic programming

95.

Systems and Methods for a Collapsible Chamber with Foldable Mixing Element

      
Application Number 18458867
Status Pending
Filing Date 2023-08-30
First Publication Date 2023-12-21
Owner Life Technologies Corporatin (USA)
Inventor Kaiser, Stephan

Abstract

The present set of embodiments relate to a system, method, and apparatus for culturing cells within a cell culture vessel having a mixing element. The cell culture system includes a flexible portion and a mixing element disposed therein. The mixing element includes a suspended foldable portion. The system is configured to reduce shear stress on cells without compromising mixing efficiency. This reduction is accomplished by using a mixing element having a large surface area allowing for reduced rotational speeds. The system is collapsible for ease of transport and disposal. The flexible portion collapses and the foldable portion folds to minimize the volume of the system while not in operation.

IPC Classes  ?

  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • B01F 27/054 - Deformable stirrers, e.g. deformed by a centrifugal force applied during operation
  • B01F 27/072 - Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
  • B01F 27/2124 - Shafts with adjustable length, e.g. telescopic shafts
  • B01F 27/1125 - Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
  • B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers

96.

COMPOSITIONS AND METHODS FOR NUCLEIC ACID ISOLATION

      
Application Number 18252283
Status Pending
Filing Date 2021-11-10
First Publication Date 2023-12-21
Owner LIFE TECHNOLOGIES AS (Norway)
Inventor
  • Jobert, Laure
  • Bosnes, Marie
  • Lindstrom, Hannah Kim

Abstract

A method of separating RNA from a sample, comprising providing: a sample comprising RNA, a binding solution comprising an oligoethylene glycol and a salt, and a solid support having a hydrophilic surface. The method further comprises contacting the sample with the binding solution and solid support, under conditions that allow binding of the RNA in the sample to the surface of the solid support, thereby providing a solid support with bound RNA in contact with residual solution; and separating the solid support with bound RNA from the residual solution. During the binding of the RNA to the surface of the solid support, oligoethylene glycol is present at a concentration of at least about 35% v/v and the salt is present at a concentration of between about 1 M and about 2 M. Methods for producing purified RNA are also provided, comprising in vitro transcription to produce an RNA molecule with a first magnetic bead and purification with a second magnetic bead. Also provided are kits and uses.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

97.

CULTURECEPT

      
Application Number 1766877
Status Registered
Filing Date 2023-11-07
Registration Date 2023-11-07
Owner Life Technologies Corporation (USA)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Cell culture media, mammalian cells, stem cell reagents, cryopreservation reagents, cell culture reagents, cell culture assays, transfection reagents, all the aforementioned for research use only.

98.

METHODS AND SYSTEMS FOR DESIGNING GENE PANELS

      
Application Number 18330479
Status Pending
Filing Date 2023-06-07
First Publication Date 2023-12-14
Owner LIFE TECHNOLOGIES CORPORATION (USA)
Inventor
  • Shtir, Corina
  • Tian, Yuan
  • Williams, Emily
  • Zhu, Yun

Abstract

A system and method of selecting genes for a gene panel, includes retrieving gene-disease associations of genes associated with diseases at a given level in the disease hierarchy from a disease association database. The disease association database stores disease information, gene information, phenotype information, associations between diseases in the disease hierarchy, gene-disease associations and strength parameters related to the gene-disease associations. For each gene associated with the diseases at the given level, the strength parameters are weighted and combined to determine a rank score for the each gene. The genes are ranked based on the rank scores to provide ranked gene information. The ranked gene information is linked with diseases at the higher levels of the disease hierarchy based on hierarchical relationships. The ranked gene information for gene-disease associations can be used to select genes for a gene panel design.

IPC Classes  ?

  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
  • G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
  • G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
  • G16B 50/30 - Data warehousing; Computing architectures
  • G16B 50/10 - Ontologies; Annotations

99.

AUTOMATED MICRODISSECTION INSTRUMENT AND METHOD FOR PROCESSING A BIOLOGICAL SAMPLE

      
Application Number 18336855
Status Pending
Filing Date 2023-06-16
First Publication Date 2023-12-14
Owner Life Technologies Corporation (USA)
Inventor
  • Baer, Thomas
  • Barker, Craig
  • Donovan, Brian
  • Youngquist, Michael
  • Wessel, Alan
  • Leclerc, Norbert
  • Smith, Michael
  • Dawson, George

Abstract

Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G01B 11/00 - Measuring arrangements characterised by the use of optical techniques

100.

MAGNIFY

      
Serial Number 98308759
Status Pending
Filing Date 2023-12-11
Owner Life Technologies Corporation ()
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical reagents, other than for medical or veterinary purpose
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