Systems and methods for analyzing flow cytometry particles. A flow cytometry system is configured to direct a fluid stream of particles through an interrogation location, and includes a laser configured to emit light toward the interrogation location to produce light signals from the particles, and one or more detectors configured convert the light signals to waveform data. The flow cytometry system includes a waveform acquisition device to continuously digitize the waveform data, and a graphics processing unit configured to apply one or more adjustable threshold voltages to the digitized waveform data to extract event data for the particles.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The present disclosure relates to dihydronaphthothiophene (DHNT), dihydrobenzodithiophene (DHBDT), and dihydronapthothienothiophene (DHNTT) monomer units and fluorescent polymers and co-polymers thereof. DHNT, DHNTT, and/or DHBDT containing water-soluble fluorescent co-polymers, water-soluble tandem fluorescent co-polymers, water-soluble fluorescent co-polymer complexes, water-soluble tandem fluorescent co-polymer complexes, and their use in methods for detecting analytes in a biological sample are also provided.
A computer implemented method, a computing device, a laboratory instrument, a computer program product and a computer readable storage medium for selectively de-ide ntifying protected health information (PHI) are provided. The method comprises accessing a first data file, the first data file comprising at least a first data item, wherein the first data item comprises PHI and first PHI category information, wherein the first PHI category information is indicative of a first PHI category of a plurality of PHI categories, the PHI in the first data item belonging to the first PHI category. The method further comprises accessing the first PHI category information. The method further comprises assessing, based on the first PHI category information, whether the PHI in the first data item is to be de-identified or not. If the PHI in the first data item is to be de-identified, the method further comprises generating a second data item by modifying the first data item such that the protected health information is de-identified.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
The disclosure relates to conjugates of the formulae (I) and (II): wherein the variables R1, R2, R3, R17, R18, R19, R20, R20A, R21, and G are defined herein, as well as methods for the use of the conjugates, and kits including the conjugates.
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
A61K 39/385 - Haptens or antigens, bound to carriers
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
C07J 1/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C07J 3/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by one carbon atom
C07J 5/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
Summarising the invention, a device is provided. The device comprises a dispensing component configured to draw and dispense liquid, wherein the dispensing component is movable with respect to a liquid sample; and a capacitive sensing component coupled to the dispensing component and configured to detect a plurality of operational states of the dispensing component, wherein each operational state of the plurality of operational states corresponds to a respective capacitance value of a plurality of capacitance values; wherein: the capacitive sensing component has a capacitive sensing range, wherein the capacitive sensing range is a predefined working range for the capacitive sensing component; and the capacitance of at least part of the device is adapted to the capacitive sensing range such that each capacitance value of the plurality of capacitance values is within the capacitive sensing range.
Maturity of a cell may be detected using a computer-implemented image analysis method which comprises capturing an image of a stained blood cell with a camera and then determining maturity for the stained blood cell. This determination may include classifying the stained blood cell before generating the stained blood cell's maturity. Corresponding systems may also be implemented, and approaches used for determining maturity of a cell may be used for detecting other characteristics, such as infection by malaria or other parasite.
A system performs a non-destructive measurement of a density gradient to automatically replicate and dispense the density gradient. The system obtains measurements at points along a length of the density gradient and generates a profile of the density gradient based on the measurements. The system uses the profile to replicate the density gradient of components in a second container. The system inserts a distal end of a probe into the second container, and pumps separate components into a manifold and mixing chamber connected to a proximal end of the probe to automatically dispense the density gradient in the second container.
G01N 9/24 - Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
G01N 9/30 - Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity by using centrifugal effects
8.
CHEMILUMINESCENT REAGENTS FOR DETECTION OF ALKALINE PHOSPHATASES
Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.
A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.
A biological imaging analyzer comprises a staining module configured to produce stained cells. The staining module comprises one or more chambers configured to receive a biological sample and a staining composition, and a heater configured to heat the biological sample and the staining composition. The analyzer also comprises a lighting module configured to illuminate the stained cells, and an imaging module configured to capture images of the stained cells. A method of staining a biological sample comprises depositing the staining composition into the one or more chambers, and pre-heating the staining composition in the one or more chambers. The method also comprises depositing the biological sample into the one or more chambers, and heating the biological sample and the staining composition in the one or more chambers.
A biological imaging analyzer comprises a flowcell (22) configured to flow biological cells therethrough, the flowcell including an imaging region where images of the biological cells are captured. The analyzer also comprises a lighting module configured to generate a light, the lighting module comprising a light guide configured to convey the light to an imaging region of the flowcell. The analyzer further comprises an imaging module (24) configured to capture images of the biological cells at the imaging region of the flowcell. The analyzer also comprises a flowcell holder in operable connection with the flowcell. A method of positioning a flowcell for biological analysis comprises providing the flowcell configured to flow a biological sample for analysis, and operably connecting the flowcell holder with the flowcell.
This disclosure provides improved assays and assay methods that include compositions comprising enzymes, such as ALP, conjugated to an antigen or antibody, as well as compositions that include enzyme substrates, wherein the compositions are optimized and adapted to provide improved assay performance. The disclosure also describes compositions of matter and kits that comprise the compositions for use in immunoassays.
A system (100, 100', 100") is provided for an automated analyzer (10) having an analyzer arrangement (12) configured to consume liquid consumables (14). The liquid consumables (14) are delivered to the automated analyzer (10) via consumables containers (20). The system (100, 100', 100") comprises a consumables container loading/unloading unit (102) comprising at least a first container holding position (Cl) and a second container holding position (C2). Each of the first container holding position (C1) and the second container holding position (C2) is configured to removably hold at least one of the consumables containers (20). The system (100, 100', 100") further comprises at least one operator accessible container station (104) accessible by an operator, such that at least one of the first container holding position (Cl) and the second container holding position (C2) is configured to directly receive the consumables containers (20) at the at least one operator accessible container station (104) from the operator. The system (100, 100', 100") further comprises at least one analyzer supply station (106) configured to deliver the liquid consumables (140 to the automated analyzer (10).
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
14.
NOVEL FLUORESCENT DYES AND POLYMERS FROM DIHYDROPHENANTHRENE DERIVATIVES
The present disclosure provides novel dihydrophenanthrene (DHP)-cyanine and DHP-squaraine fluorescent compounds and water-soluble polymers thereof. The DHP- cyanine and DHP-squaraine fluorescent compounds and polymers can be excited using UV, violet, blue, yellow, green, red, or NIR wavelengths. The fluorescent dyes may be conjugated to antibodies for detection of target analytes in biological samples and are suitable for use in flow cytometry analyses.
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
C09B 69/10 - Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
15.
METHOD AND INSTRUMENT FOR DRAWING A VOLUME OF A BIOLOGICAL SAMPLE FOR TESTING
Summarizing the invention, a method is provided. The method comprises: accessing test order data, wherein the test order data comprise information specifying a set of clinical tests to be carried out on a biological sample, wherein the set of clinical tests comprises at least a clinical test and the biological sample is contained in a sample container; obtaining test volume data by using the test order data, wherein the test volume data comprise information specifying a test volume; and instructing a pipetting device of a laboratory instrument to draw a drawing volume of the biological sample from the sample container, the drawing volume being based on the test volume data; wherein the test volume is the volume of the biological sample needed to carry out: the clinical test, and one or more supplementary tests associated with the clinical test, whenever one or more test volume conditions associated with the clinical test are met, wherein the one or more test volume conditions comprise a condition that one or more rules require that the one or more supplementary tests shall be carried out whenever one or more supplementary test conditions on the clinical test are met.
G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The present disclosure provides a sample handling arrangement (100, 100', 100'') for transferring one or more patient samples or portions thereof from at least one sample tube (20) to at least one reaction vessel (22) within an automated analyzer (50, 50'). The sample handling arrangement (100, 100', 100'') includes a sample presentation unit (102) associated with the automated analyzer (50) and configured to receive a plurality of racks (26) into the automated analyzer (50). Each of the plurality of racks (26) is configured to receive and hold the at least one sample tube (20). The sample handling arrangement (100, 100', 100'') further includes a linear slide (114) configured to be selectively mounted to a mount of the automated analyzer (50) at a first position (Pl) and a second position (P2) different from the first position (P2). The sample handling arrangement (100, 100', 100'') further includes a pipetting module (112) configured to travel along the linear slide (114) and transfer the one or more patient samples or portions thereof to the at least one reaction vessel (22) within the automated analyzer (50, 50').
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A pipetting instrument for loading and dispensing a sample is described. The pipetting instrument includes an automated liquid pipettor having a deck for supporting a pipette tip box comprising pipette tips, and mandrels for engaging the pipette tips and withdrawing at least some of the pipette tips from the pipette tip box. The pipetting instrument further includes a controller configured to control the automated liquid pipettor, the controller further configured to execute a pipette tip dislodging operation to dislodge any undesired pipette tips that are withdrawn from the pipette tip box using the mandrels.
An aspect of the present invention relates to a computer-implemented method comprising the steps of: obtaining, from or by a first computing device, log data, the log data comprising a first plurality of log data items; and obtaining anomaly data, the anomaly data comprising information indicative of the presence of an anomaly in a laboratory instrument, wherein the first computing device is configured to access a log file of the laboratory instrument, the log file comprising a first plurality of log file entries, each log file entry of the first plurality of log file entries comprising a plurality of fields, and to construct the log data, by, for each log data item of the first plurality of log data items: selecting first field-data of a first field of a respective log file entry, the first field of the respective log file entry specifying a respective event which has occurred in the laboratory instrument; selecting second field-data of a second field of the respective log file entry, the second field of the respective log file entry further describing the respective event occurred in the laboratory instrument, wherein the selecting of the respective second field is based on the first field-data of the respective first field of the respective log file entry; and constructing said each log data item by using the first field-data of the first field of the respective log file entry and the second field-data of the second field of the respective log file entry. Additional aspects of the present invention relate to further computer-implemented methods, a data processing system, a laboratory instrument, an automated laboratory system, a computer program product, and a computer-readable medium.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A detection system for a flow cytometer includes a light source configured to generate an excitation light beam. A suppression element has a first portion having a first characteristic, and a second portion surrounding the first portion. One or more differences between the first and second characteristics cause a phase shift between light fringes and a high intensity core of the excitation light beam resulting in suppression of the light fringes.
An aspect of the present invention relates to a computer-implemented method, the method comprising at least the steps of: obtaining, by a first computing device, sample location data, the sample location data comprising information indicative of a sample location of a biological sample; obtaining, by the first computing device, test data, the test data comprising information indicative of one or more clinical tests to be performed on the biological sample; selecting by evaluating laboratory data, by the first computing device, a processing laboratory from a first plurality of laboratories, wherein the processing laboratory is located at a processing laboratory location and the processing laboratory comprises one or more laboratory instruments, the one or more laboratory instruments being configured to carry out the one or more clinical tests to be performed on the biological sample; and instructing, by the first computing device, an agent to initiate a transfer of the biological sample from the sample location to the processing laboratory location. Further aspects of the present invention relate to another computer-implemented method, a computer program product and a system.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
A light detecting system and a light detecting method for a flow cytometer are provided. The light detecting system includes a beam separating device and multiple wavelength division multiplexing devices. The beam separating device is configured to separate a beam to be processed by the flow cytometer into multiple first beams having respective wavelength ranges that either do not overlap with each other or partially overlap with each other. Each of the multiple wavelength division multiplexing devices is configured to receive a respective one of the multiple first beams. The multiple first beams are parallel to each other when received by the multiple wavelength division multiplexing devices. Each of the multiple wavelength division multiplexing devices includes multiple light detecting devices being configured to detect a portion of the respective first beam.
A microscope imaging system includes an objective (18) configured to collect light from a biological sample (S) for forming a magnified image of the biological sample. The microscope imaging system also includes a camera (14) including an imaging sensor. The imaging sensor is configured to detect the magnified image of the biological sample. The microscope imaging system further includes a tube lens (16) positioned between the objective and the camera. The tube lens is configured to project the magnified image of the biological sample onto the imaging sensor of the camera. The tube lens is spaced apart from the imaging sensor of the camera by a distance (D2) less than a focal length of the tube lens.
An analyzer may have its operation validated using control samples which comprise synthetic particles. Such an analyzer be adapted to obtain a representation of a particle from a sample and obtain a classification of the particle which classifies the particle as a type specific to control samples. The analyzer may also be adapted to perform control specific processing on the sample, and to generate an analysis output for the sample based on a result of the control specific processing.
A computer-implemented method is provided. The method comprises: accessing, by a first computing device, sample-processing data, wherein the sample-processing data comprise information indicative of a set of procedures to be carried out on a biological sample, wherein each procedure comprises one or more actions; obtaining, by the first computing device, ALS1 state data, wherein the ALS1 state data comprise information indicative of a state of a first automated laboratory system – ALS1; obtaining, by the first computing device, ALS2 operation data, wherein the ALS2 operation data comprise information indicative of an ALS2 set of actions of at least a first procedure, wherein the ALS2 set of actions either has been carried out or is scheduled to be carried out by a second automated laboratory system – ALS2 – on the biological sample; generating, by the first computing device, ALS1 processing data by using the sample-processing data, the ALS1 state data and the ALS2 operation data, wherein the ALS1 processing data comprise information indicative of an ALS1 set of actions of at least a second procedure of the sets of procedures; and initiating, by the first computing device, the generation of an ALS1 route plan for the first automated laboratory system, the ALS1 route plan being based on the ALS1 processing data.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
This disclosure describes methods of and systems for screening for sepsis or septic shock in a patient and methods of ruling out sepsis or septic shock in a patient using white blood cell count (WBC), a monocyte cell population parameter, or neutrophil-to-lymphocyte ratio (NLR), or a combination thereof, in the blood sample from the patient
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
A visual analysis system may be automatically focused (or the focus of such a. system may be automatically corrected) by subjecting one or more images captured by such a system to a multi- layer analysis. In such an analysis, a cell boundary may be identified in an input image based on the lightness value of the pixels of the input image. Based on the identified cell boundary, a predicted nominal focus value is determined which can provide a focusing distance (e.g., a distance between the focal plane of a camera used when an image was captured and the actual focal plane for an in-focus image). This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).
A method of installing a module associated with a life sciences laboratory workstation includes positioning at least a portion of at least one rail to extend outside the laboratory workstation; disposing the module on the at least one rail at a first position that is at least partially outside of the laboratory workstation; moving the module from the first position to a second position within the laboratory workstation via the at least one rail positioned within the laboratory workstation; transferring the module from the at least one rail to an actuator platform located within the laboratory workstation; and causing the actuator platform to position the module at a predetermined position within the laboratory workstation.
B01L 9/02 - Laboratory benches or tables; Fittings therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
The present disclosure provides a method (400) of detecting bubbles (12) in a sample liquid (10) disposed in a container (102). The method (400) comprises capturing a first image (210) of the container (102) at a first time instance; capturing a second image (212) of the container (102) at a second time instance after the first time instance; comparing the first image (210) with the second image (212) to determine a pattern matching score (S1); and determining a presence of bubbles (12) in the sample liquid (10) if the pattern matching score (S1) crosses a predetermined threshold score (S2).
A biological analysis system includes a flow generator, a flowcell, a first flow path, and a second flow path. The flow generator is configured to provide a sheath fluid. The flowcell is configured to receive a biological sample. The first flow path is in fluid communication with the flow generator and configured to receive a first portion of the sheath fluid from the flow generator. The first flow path is configured to convey the biological sample using the first portion to the flowcell at a first flow rate. The second flow path is in fluid communication with the flow generator and configured to receive a second portion of the sheath fluid from the flow generator. The second flow path is configured to convey the second portion to the flowcell at a second flow rate. The second flow rate is different than the first flow rate.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
The present disclosure provides a computing device (100) for classification of an aspirating/dispensing operation in an automated analyzer (50). The computing device (100) comprises a memory (22) storing a neural network model (24). The neural network model 24 sequentially comprises a plurality of convolution blocks (202-1, 202-2...202-N). The computing device (100) further comprises a processor (20) communicably coupled to the memory (22) and at least one measurement sensor (106) associated with a pipetting probe (104) of a pipetting device (102). The processor (20) is capable of executing the neural network model (24). The processor (20) is further capable of executing instructions (26) to classify the aspirating/dispensing operation into at least one correct class or at least one incorrect class.
In a method for controlling a centrifuge (100) comprising a rotor (106) and a drive component (104) for the rotor (106), an acoustic signal (AS) is received, at a computing device (102), via a sound transducer (108) located proximate to the rotor (106) of the centrifuge (100). The acoustic signal (AS) is pre-processed, by the computing device (102), by emphasizing at least one predetermined signal feature of the acoustic signal (AS), the signal feature indicating an abnormal operation of the centrifuge (100). An abnormal operation of the centrifuge (100) is detected, by the computing device (102), by processing the emphasized signal feature. An alarm signal and/or a termination signal (212) is generated, by the computing device (102), if an abnormal operation of the centrifuge (100) is detected.
A tube from a plurality of tubes from a tube rack configured to removably hold the plurality of tubes are removed from a tube rack. A weight of the tube which has been removed from the tube rack is determined. A balancing parameter of the tube is determined by a computing device. An estimated balancing parameter of each of a plurality of remaining tubes from the plurality of tubes in the tube rack is determined. A corresponding rotor position from a plurality of rotor positions within the rotor for the tube is determined by the computing device based at least on the balancing parameter of the tube, the balancing parameters of previously placed tubes from the plurality of tubes placed within the rotor and the estimated balancing parameter of each of the plurality of remaining tubes. The transport unit places the tube in the corresponding rotor position within the rotor.
A biological analysis system includes a probe. The probe is configured to dispense a biological sample into a first chamber. The system also includes a pump. The pump is configured to convey a first delivery of diluent to the first chamber for mixing with the biological sample to produce a sample mixture, aspirate a portion of the sample mixture from the first chamber, and convey the portion of the sample mixture to a second chamber. A method of analyzing a biological sample includes conveying a diluent to a first chamber via a first pump, dispensing a blood sample into the first chamber via a probe to produce a sample mixture, and conveying a portion of the sample mixture from the first chamber to a second chamber via the first pump.
A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).
A sample analysis system analyzes a sample. A panel design generates a sample preparation specification. A preparation instrument prepares a sample using the sample preparation specification to generate a prepared sample. A sample analyzer analyzes the prepared sample. A validator validates an operation of the sample analysis system. A sample analysis system has a transfer station that controls the movement of a probe with respect to a reaction plate. A probe wash module is also disclosed.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A system for acquiring the image data of refrigerated materials is disclosed. The system includes a material management unit with an imaging system. The material management unit further includes a refrigerated chamber in which material vials are stored. The imaging system includes a window positioned on the side of the material management unit that separates an interior space of the refrigerated chamber from an exterior space of the material management unit. The imaging system further includes a camera positioned in the exterior space that captures image data through the window. The window is heated along its sides by a heating element, which functions to prevent condensation from forming on the surface of the window.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
37.
METHOD FOR ARCHIVING A SAMPLE TUBE, METHOD FOR RETRIEVING A SAMPLE TUBE AND TUBE RACK
An aspect of the present invention relates to an archiving method for archiving in a storage, in particular in a cold storage, at least one sample tube containing a biological sample using at least one tube rack, the method comprising the following steps: receiving, by a computing system, a request for archiving the at least one sample tube, placing the at least one sample tube in at least one receptacle of the at least one tube rack to receive the at least one sample tube, recording and/or updating, in a memory unit of the computing system, sample-tube-storage-data including sample tube data and/or tube rack data and/or storage data, storing the at least one tube rack in the storage. Further aspects relate to a retrieving method and a tube rack.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
38.
SYSTEM AND METHODS FOR SURFACE ENHANCED RAMAN SPECTROSCOPY
The described technology provides systems (100) and methods for determining concentration of an analyte (308) of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system (100) can include a body (102) for accepting a substrate (200, 210, 220, 230, 240, 300), a fluid handling system (104), a light source (108), and a detector (106) that collects and detects Raman scattered light.
A method for automatically defragmenting pipette tips in a tip tray during the performance of a procedure defined by a protocol stored in memory of a fluid handling system, the method comprising determining locations of open receptacles in the tip tray where pipette tips are absent, determining locations of filled receptacles in the tip tray where pipette tips are present, and using the fluid handling system to move pipette tips from filled receptacles to open receptacles to complete strings of filled receptacles in the tip tray.
A computer-implemented method of determining a major adverse cardiovascular event, risk of MACE, in a patient, is provided. The method comprises receiving, with a computing device, subject value data for the patient, the subject value data including (i) at least one troponin value, (ii) at least one demographic value, and (iii) at least one of a value for prior history of cardiac disease, a value of prior history of renal disease, an erythrocyte mean corpuscular hemoglobin value and an electrolyte value. Further, the method comprises evaluating, with the computing device, the received subject value data, of the patient based on a reference dataset indicative of reference subject values associated with one or more reference patients, wherein the reference dataset is indicative of reference subject values including (i) al least one troponin value, (ii) at least one demographic value, and (iii) a value for prior history of cardiac disease. Further, the risk of MACE is determined based on the evaluation.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
41.
NOVEL FORMULATION FOR DRYING OF POLYMER DYE CONJUGATED ANTIBODIES
A novel dry down buffer is provided for use in drying a plurality of fluorescent dye conjugates on a substrate for use in flow cytometry. The aqueous buffer comprises a water-soluble monomer; a protein stabilizer; a carbohydrate stabilizer; and a zwitterionic surfactant. When mixed with a multi-color panel comprising fluorescent polymer dye conjugates, dried on a substrate, and reconstituted with a biological sample, the buffer provides decreased aggregation of fluorescent polymer dye conjugates, and decreased non-specific binding of monocytes and granulocytes, when compared to use of a buffer without the water-soluble monomer or zwitterionic surfactant.
A sorting flow cytometer receives a current alignment of a light beam, determines a difference between the current alignment of the light beam and a target alignment of the light beam, and calculates one or more voltage values based on the difference between the current alignment and the target alignment. The sorting flow cytometer uses the voltage values to adjust a position of at least one of a first alignment actuator extending in a first axial direction and a second alignment actuator extending in a axial second direction to reduce the difference between the current alignment of the light beam and the target alignment of the light beam.
G02B 7/182 - Mountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
43.
CONSUMABLES CONTAINER LOADING/UNLOADING SYSTEM AND METHOD OF LOADING/UNLOADING CONSUMABLES CONTAINERS FOR AUTOMATED ANALYZER
A system (100) is provided for an automated analyzer (10) having an analyzer arrangement (20) configured to consume liquid consumables (30L) when in an active mode (12). The liquid consumables (30L) are delivered to the automated analyzer (10) via consumables containers (30). The system (100) comprises a storage magazine (120) configured to removably hold at least one of the consumables containers (30), a tray (150) configured to manually receive one or more of the consumables containers (30) from an operator at least while the analyzer arrangement (20) is in the active mode (12), and a transfer system (250) configured to transfer one or more of the consumables containers (30) at least between the tray (150) and the storage magazine (120). The transfer system (250) transfers one or more of the consumables containers (30) to or from the storage magazine (120) at least while the tray (150) manually receives one or more of the consumables containers (30) from the operator.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
Disclosed are systems and methods for detecting a malfunction in an automated analyzer. The systems and methods may include receiving a signal from a sensor (116), such as a Hall effect sensor located proximate a coil (104) of a solenoid valve (100). The signal from the sensor may be correlated to a magnetic flux or change in the magnetic flux generated as a plunger (102) of the solenoid valve is drawn into the coil when the coil is energized. Deviations in the signal from a reference may indicated a malfunction of the solenoid valve. Upon detecting a malfunction, a pre-failure status may be determined.
F16K 31/06 - Operating means; Releasing devices magnetic using a magnet
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
H01F 7/18 - Circuit arrangements for obtaining desired operating characteristics, e.g. for slow operation, for sequential energisation of windings, for high-speed energisation of windings
45.
SAMPLE TUBE, SAMPLE TUBE CLOSING DEVICE AND METHOD FOR CLOSING A SAMPLE TUBE
The present invention relates to a sample tube (10), a sample tube closing device for closing a sample tube (10) and a method of closing a sample tube (10), the sample tube (10) comprising: a bottom portion (30), a tubular portion (20), and an opening portion (40), wherein the opening portion (40) comprises a foldable structure (41 ) configured to be foldable in a predetermined manner from an open state into a closed state.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B65D 1/16 - Cans, casks, barrels, or drums characterised by shape of curved cross-section, e.g. cylindrical
B65D 3/04 - Rigid or semi-rigid containers having bodies or peripheral walls of curved or partially-curved cross-section made by winding or bending paper without folding along defined lines characterised by shape essentially cylindrical
B65D 5/36 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper specially constructed to allow collapsing and re-erecting without disengagement of side or bottom connections
B65D 47/06 - Closures with discharging devices other than pumps with discharge nozzles or passages
B65D 47/10 - Closures with discharging devices other than pumps with discharge nozzles or passages having frangible closures
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
B65D 41/00 - Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
B65D 43/00 - Lids or covers for rigid or semi-rigid containers
46.
WATER-SOLUBLE TETRAHYDROPYRENE BASED FLUORESCENT POLYMERS
The present invention provides water-soluble tetra hydropyrene based fluorescent polymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample. The tetrahydropyrene based fluorescent polymers have the following general formula.
The present disclosure provides a method (400) of evaluating a fluidic substance (10) having particles (11). The method (400) comprises capturing a reference image (202) of at least a portion of a container (102) that is in an empty state; determining a reference grayscale value (V1) of at least a portion of the reference image (202); aspirating a volume of the fluidic substance (10) into the container (102); capturing a test image (252) of the container (102) containing the aspirated volume of the fluidic substance (10); determining a test grayscale value (V2) of at least a portion of the test image (252); calibrating a universal calibration curve (56) relating particle concentration and grayscale value based on the reference and test grayscale values (V1, V2); and determining a particle concentration (P1) in the fluidic substance (10) based on the test grayscale value (V2) and the calibrated universal calibration curve (60).
The presently claimed and described technology provides an apparatus (500, 1000A, 1000B) configured to adjustably position a focal location (14) of a first instrument (12) of a first body (10, 20, 60) with respect to a target location (44, 54) of a second instrument (42, 42H, 42U, 52) of a second body (40, 50). The apparatus further includes a third body (30), a first joint (210), and a second joint (310). The first joint is configured to adjustably linearly position the first body with respect to the third body along a first axis (A2) and thereby perform a first adjustment and is further configured to adjustably rotatably position the first body with respect to the third body about the first axis (A2) and thereby perform a second adjustment. The second joint is configured to adjustably linearly position the second body with respect to the third body along a second axis (A3) and thereby perform a third adjustment and further configured to adjustably rotatably position the second body with respect to the third body about the second axis (A3) and thereby perform a fourth adjustment. Each of the first, second, third, and/or fourth adjustments are performed independently of each other and may have zero backlash. Additional third axis (Al, A1A, A1B) linear and/or rotational adjustment mechanism(s) may be added. In certain embodiments, the first, second, and/or third axes intersect each other at a point (P).
A detection system and a sample processing instrument for nanoparticles are provided. The detection system includes a light emitting unit and a light collection unit. The light emitting unit is configured to emit a light beam and project the light beam onto a nanoparticle to be detected. The light collection unit is configured to collect light beams from the nanoparticle so as to analyze the nanoparticles according to the collected light beams. The light emitting unit includes multiple light sources and a focusing lens, and the light beams emitted by the multiple light sources are focused through the focusing lens on a same detection position through which the nanoparticle is to pass.
An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use with a particular microbe. The testing method includes iteratively imaging the microbes mixed with various concentrations of the antimicrobic. The images are thereafter processed to identify curvilinear structures, which are bucketed and provided as input to a machine learning model such as a decision tree classifier. The output of the model would then make a prediction regarding the MIC, such as a prediction of growth or no growth for each well (in which case the lowest concentration in a well with a prediction of no growth may be treated as the MIC), or a prediction of the MIC directly.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
C12Q 1/18 - Testing for antimicrobial activity of a material
Summarizing the invention, a computer-implemented method is provided. The method comprises: accessing, by a first computing device, test data and instrument data, wherein: the test data comprise information specifying at least one clinical test to be carried out on a biological sample of a subject, the instrument data comprise information specifying a state and/or a configuration of a set of laboratory instruments, and at least one laboratory instrument of the set of laboratory instruments is configured to carry out the at least one clinical test; generating, by the first computing device, sample-collecting data by using at least the test data and the instrument data, wherein: the sample-collecting data comprise at least one of a sample volume requirement and a sample container requirement, the sample volume requirement comprises one or more suitability constraints on a volume of the biological sample, and the sample container requirement comprises one or more constraints on a container in which the biological sample Is to be held; providing, by the first computing device, the sample- collecting data to a phlebotomy agent.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
52.
APPARATUS, METHOD AND SYSTEM FOR PROCESSING SAMPLE TUBES
Summarizing the invention, an apparatus configured to interact with a tube rack, the tube rack comprising a data storage element, is provided. The apparatus comprises: - a data reading unit configured to read first data from a sample tube when the sample tube is arranged at a reading position with respect to the data reading unit; - a detection unit comprising at least one sensor configured to detect the presence of the sample tube in the tube rack if the tube rack is at a detection position with respect to the at least one sensor; - a computing unit configured to write second data to the data storage element when the at least one sensor detects the presence of the sample tube in the tube rack.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
A method for performing a function check of a fluid handling system can comprise dispensing a first reference dose of a fluid into a reference container using a first fluid dispenser, measuring a first fluid height of the first reference dose in the reference container with a fluid level sensing system of the fluid handling system, and changing a status of the fluid handling system based on the first measured first fluid height. Robotic fluid handling system can comprise controllers and computer readable memory configured to execute the methods described herein.
Techniques for oblique illumination of samples in microscopy imaging are presented. The sample may be obliquely illuminated by directing light from a light emitter toward a sample at an oblique angle, rather than directly along the optical axis of an imaging device. The oblique angle may be created using an aperture mask with an aperture that is not coaxial with the optical axis of the imaging device. The oblique angle may also be created using a light emitter and collector lens that are not coaxial with the optical axis of the imaging device, such that the condenser lens directs the light toward the sample. Images obtained using the oblique illumination provide improved contrast of translucent particles and may have an embossed, three-dimensional appearance.
A gassing lid assembly enables gas-tight sealing of sample containers in general, also referred to as microplates in some embodiments, with simultaneous guided access for the pipetting unit of a dispensing/pipetting robot, also referred to as a pipettor. The component enables both gas-tight sealing and guided access for the pipetting robot. The gassing lid serves a number of purposes at the same time and provides the following advantages in a non-limiting fashion: a gas tight seal, robot integration without a gassing lid, robot integration with a gassing lid, a sealing mechanism, and anaerobic transport. Reducing the volume above reservoirs of a sample container (e.g., the volume above wells of a microplate) is advantageous in that it reduces the safety risk of high concentrations of gases such as oxygen.
A workflow and associated system for controlling pH is described that allows for real-time pH adjustment in parallel culture wells of a microplate. For example, a biological process control system comprised of a pH measurement system, a controller, and a pH adjustment system implements a closed control loop, where a pH of a culture well measured by the pH measurement system is compared to a predetermined pH for the culture well, and, if there is a deviation, a pH adjustment system adjusts the pH in the culture well to correct the deviation as the system continues on to measure, evaluate, and adjust, if needed, remaining microplate culture wells. Therefore, by performing per-well pH evaluation and adjustment in real-time upon receiving the measured pH rather than waiting until pH of all culture wells are measured, the measured pH used as a basis for pH adjustment is a current, accurate measurement.
The present disclosure provides UV-absorbing polymer dyes and methods for detecting an analyte in a sample by using a binding partner conjugated to a UV- absorbing polymer dye. Compositions comprising UV-absorbing polymer dyes, UV- absorbing tandem dyes, or quenched UV polymer dyes are provided.
A gassing lid assembly enables gas-tight sealing of sample containers in general, also referred to as microplates in some embodiments, with simultaneous guided access for the pipetting unit of a dispensing/pipetting robot, also referred to as a pipettor. The component enables both gas-tight sealing and guided access for the pipetting robot. The gassing lid serves a number of purposes at the same time and provides the following advantages in a non-limiting fashion: a gas tight seal, robot integration without a gassing lid, robot integration with a gassing lid, a sealing mechanism, and anaerobic transport. Reducing the volume above reservoirs of a sample container (e.g., the volume above wells of a microplate) is advantageous in that it reduces the safety risk of high concentrations of gases such as oxygen.
According to various aspects of the instant disclosure, a rapidly-sedimenting magnetic particle can include a core or inner layer. The core or inner layer can include a ferrimagnetic material and have at least one of a maximum field strength ranging from about 20 emu/g to about 250 emu/g, and a remanence ranging from about 0 emu/g to about 20 emu/g. The rapidly-sedimenting magnetic particle can further include a coating layer overlaying at least a portion of the core or inner layer. The particle can further include an outer coating layer overlaying at least a portion of the core coating.
The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
The present disclosure relates to a fluid system for a sample processor and a sample processor including the fluid system. The fluid system includes a sample line, a processing fluid line, a vacuum line, and an air pump. The sample line communicates a sample container with a sample port of a flow cell unit. The processing fluid line communicates a sheath fluid container with a processing fluid port of the flow cell unit. The vacuum line is in communication with the flow cell unit. The air pump includes a first output port and a second output port. Pressurized gas is generated at the first output port, and the first output port is in communication with the sample container and the sheath fluid container. A vacuum is generated at the second output port, and the second output port is in communication with a vacuum port of the flow cell unit through the vacuum line.
The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device. The system includes: a first laser source configured to emit a first laser beam to a liquid flow of a sorting device, the first laser beam and the liquid flow intersecting at a first laser interrogation point located in a nozzle system of the sorting device; a second laser source configured to emit a second laser beam to the liquid flow, the second laser beam and the liquid flow intersecting at a second laser interrogation point located outside the nozzle system; a first detector and a second detector which are respectively used for detecting emission, in response to the first laser beam and the second laser beam, of a particle in the liquid flow; and a droplet delay time calculation unit configured to calculate, on the basis of the time when the particle in the liquid flow passes through the first laser interrogation point and the time when the particle passes through the second laser interrogation point, a first delay time for the liquid flow flowing from the first laser interrogation point to the second laser interrogation point, and calculate, on the basis of the first delay time, a droplet delay time.
The present disclosure relates to a nozzle for a sample processor, a carrier of a nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a detachable manner. The orifice is provided in the body and is configured to inject a sample from an injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and the sample processor according to the present disclosure include the above-described nozzle and carrier. With the aid of the carrier, it is not necessary to install the nozzle to the injector body upstream of the nozzle, so that various adjustment operations when reinstalling the nozzle can be omitted, thereby simplifying the process of reinstalling the nozzle.
The presently claimed and described technology provides improved calibration and validation procedures for sample containers (e.g., cuvettes) in automated chemical analyzers. The claimed and described technology further provides methods of operating an automated analyzer that allows for the automation of calibrating and tracking the integrity of individual sample containers (e.g., cuvettes) in parallel with measuring constituent samples. These methods eliminate the need to alternate between a diagnostic mode and measurement mode when performing system maintenance, such as validating cuvette integrity, calibrating absorbance baseline, and replacing cuvettes. As such, the presently claimed and described technology can reduce downtime and improve the clinical lab productivity significantly by allowing for this system maintenance to occur simultaneously with sample analysis.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 21/90 - Investigating the presence of flaws, defects or contamination in a container or its contents
65.
SIMULTANEOUS AND SELECTIVE WASHING AND DETECTION IN ION SELECTIVE ELECTRODE ANALYZERS
A considerable amount of time is required for calibration and compliance service for electrolyte measuring devices with ion selective electrode analyzers in most clinical or diagnostic laboratory settings. Often a user has to make trade-offs between improving diagnostic accuracy and processing higher workloads faster and more predictably. Current electrolyte measuring devices with ion selective electrodes are unable to balance the increased requirements for accuracy and speed. The presently claimed and described technology provides an improved device for an ion selective electrode analyzer. The presently claimed and described technology also provides methods for simultaneous and selective washing of components of the ion selective electrode analyzer and methods for simultaneous and selective analysis of samples using the ion selective electrode analyzer in an automated chemical analyzer.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/02 - Particle spectrometers or separator tubes - Details
H01J 49/06 - Electron- or ion-optical arrangements
66.
CLINICAL LABORATORY AUTOMATION SYSTEM WITH SINGLE CALIBRATOR
An external calibration curve relies on external calibrators containing known concentrations of a target analyte that can deteriorate over time, leading to inaccurate results. Generating new calibration curves often requires preparing several calibrators to obtain calibration points needed for generating the calibration curves. Preparing the calibrators necessary for multi-point calibration curves requires operator preparation time and can introduce handling errors. The presently claimed and described technology provides a clinical laboratory automation system, including a fluid handling system, an analyzer component, and a mass spectrometer. The clinical laboratory automation system can provide automated calibration using one calibrator to prepare one or more calibrator dilutions used to generate a calibration curve for the quantitative measurement of a target analyte in a sample. The clinical laboratory automation analyzer may also provide an automated evaluation of pipettor dispensing volume and adjustment of the pipettor actuator to deliver an accurate dispensing volume.
The presently claimed and described technology provides integrated automated instruments (100, 100A, 100B, 100C) and methods (800) for automatically processing a whole blood sample (50) in a single sample tube (80). These include: mixing the sample in the tube; analyzing a portion (50P) of the mixed sample (50M); centrifuging the sample in the tube thereby separating plasma (60); and analyzing a portion (60P) of the plasma. A pretreatment module (200) may mix, centrifuge, transport, and store the sample. The integrated instrument may include multiple detector components and does not require external sample handling.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
A system comprises: a sample analyzing device reading measurements associated with a liquid sample; a display device displaying a graphical user interface (GUI) to a current user of the automated sample analyzer; processing circuitry; and a memory storing: a receiving engine which receives the measurements associated with the liquid sample from the sample analyzing device and storing the received measurements in memory; a configuration control engine which sets a configuration of a user model to correspond to the current user of the automated sample analyzer; a learning engine which detects and collect at least one pattern of interaction of the current user with the GUI; and a user interface engine which configures the GUI according to user-dependent configuration data of the configuration of the user model corresponding to the current user.
G06F 9/451 - Execution arrangements for user interfaces
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G06N 3/04 - Architecture, e.g. interconnection topology
The disclosure relates to a substrate comprising a micro- or nanostructured periodic array comprised of a plurality of anisotropic metallic micro- or nanostructures, wherein each of the plurality of nanostructures induce an average maximum and substantially uniform plasmonic field greater than 108 across the substrate; a plurality of Raman-active linker molecules directly bound to the metallic micro- or nanostructures; and a plurality of capture molecules directly bound to the Raman-active linker molecules. The disclosure also relates to systems, devices, and methods that use the substrates to determine the concentration of various analytes.
Disclosed are dispensers (100, 200, 300) and methods for dispensing and degassing a liquid (102). The dispensers and methods may include a heater (308) and a first tube (124, 502) constructed of a first material. The first tube may include a first end (124A) operable to be connected to a source (104) of the liquid and a second end (124B). The first tube may be connected to the heater via a conductive pathway thermally connecting the heater to the first tube. The first material may have a permeability such that a portion of the gas dissolved in the liquid passes through the first material to an atmosphere upon being degassed from a portion of the liquid within the first tube (124, 502).
Embodiments of the present disclosure relate to a method, system and apparatus for setting a clotting time for a blood sample contained in a container in a laboratory device or test system, which includes setting a clotting start time for the blood sample, setting a clotting wait time to allow for the blood sample to clot, and on positive determination of the completion of the clotting wait time, automatically providing the blood sample for further processing in the laboratory.
Systems and methods of assessing a probability that an individual will develop sepsis are provided. The systems and methods can include obtaining a set of parameters associated with the individual including white blood cell count (WBC) and monocyte distribution width (MDW) value, and determining whether the set of parameters provides an elevated risk status by comparing at least the WBC and the MDW value with respective predetermined criteria. In the event that the set of parameters is determined to provide the elevated risk status, the systems and methods can further include obtaining a secondary parameter associated with the individual; and providing the probability that the individual will develop sepsis.
Compositions, methods, and kits for stable Trypan Blue solutions are provided. In one example, a method includes: cooling a solution of Trypan Blue; and filtering the cooled solution. In another example, a method includes: mixing a water-soluble polymer with a Trypan Blue solution. The method may further include adding one or more ingredients such as an aqueous buffer, an osmolyte, an acid, a base, a buffer, a cell culture medium, water, or combinations thereof.
Systems and methods for providing clinical decision support information including one or more clinical acuity recommendations to a clinician is provided. The systems and methods can include obtaining one or more parameters associated with a blood sample obtained from an individual, the one or more parameters can include a monocyte distribution width (MDW) value. The systems and methods can also include comparing the MDW value with one or more predetermined criteria; and providing a clinical acuity recommendation at least partly in response to the comparing the MDW value with the one or more predetermined criteria.
A chemistry analysis machine and method for using the machine include adding heating functionality to provide faster test specimen heating times or comparable specimen heating times while using containers or cuvettes made of materials such as plastic that have lower thermal conductivity. In one example, a mixing bar is heated prior to contacting the test specimen within the container to provide the additional heating capability to the system. In one example where the mixing bar is heated, a heater is added to the system to heat the rinse water used to rinse the mixing bar after it is washed and prior to its next use in contacting a test specimen.
An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use on a sample. This may include iteratively imaging wells inoculated with the sample and containing various concentrations of the antimicrobic. The images are thereafter processed to identify MIC based on sequences in information provided as input to a machine learning model.
The disclosure relates to methods and compositions for reducing or eliminating non-specific binding of at least one dye conjugate to cells in a biological sample. A dye conjugate is contacted with at least one zwitterionic or anionic surfactant before, during or after the dye conjugate is contacted with a blood sample, resulting in substantially reduced non-specific binding of the dye conjugate to cells in the biological sample.
Systems and methods for identifying Multisystem Inflammatory Syndrome in Children (MIS-C) may use various hematological parameters and combinations of hematological parameters. Such parameters and combinations may use monocyte distribution width (MDW), though other parameters may also be used. Using this approach, area under curve values of 0.8 or greater may be achieved. Such parameters may also be used in treatment of MIS-C, including evaluation of status of hospitalized patients to determine when such patients may be safely discharged.
A method of framing a workspace for a working tool of a robotic fluid handler comprises positioning a liquid dispenser within a workspace of the robotic fluid handler using a transport device, moving the liquid dispenser to a general location of a component of the workspace, contacting the liquid dispenser to multiple features of the component, determining a specific location for the general location based on contacting of the liquid dispenser to the multiple features, and registering the specific location to the workspace.
The disclosure relates to, among other things, an automated flow cytometric method and system for the analysis and enumeration of at least one of hematopoietic stem cells, hematopoietic progenitor cells, and T-cells.
A method is performed at a graphics processing unit (GPU) comprising multiple GPU processor cores. The method includes: at each GPU processor core of at least a subset of the multiple GPU processor cores of the GPU: training, for a plurality of episodes, a reinforcement learning (RL) engine to solve a given problem by updating coefficients of the RL engine. The method includes: upon completion of the plurality of episodes at each GPU processor core of the at least the subset of the multiple GPU processor cores of the GPU: combining, using the GPU and without using a central processing unit (CPU) external to the GPU, the coefficients from the multiple GPU processor cores using a transformation function, and providing the combined coefficients to each GPU processor core for further training. The method includes: stopping training the RL engine upon determining that a stopping condition has been reached.
Methods for evaluating a viral infection status using laboratory-based immunoassay or hematology parameters. Evaluation of particular combinations of hematology parameters may indicate active viral infection in a patient, and, in particular, may indicate active COVID-19 disease in a patient, which is a disease caused by infection with a coronavirus known as Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Specifically, the method comprising detecting the presence of IgG or IgM antibodies in a sample that is specific for the receptor binding domain (RED) of the spike (S1) protein of SARS-CoV-2.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
Monitoring devices, such as air particle counters, having mesh network capabilities are described for implementation in environmental monitoring within a facility. The air particle counters run samples at various facility locations based on a standard operating procedure (SOP). Each air particle counter can opportunistically connect with one or more other air particle counters using mesh networking. Data from samples run by and any new or updated SOP received at the air particle counters can be distributed via database replication across the other air particle counters using the mesh networking such that each air particle counter has a copy of the sample data and a current SOP within its database. A dashboard user interface displaying a hierarchical representation of the SOP and an associated compliance status with the SOP can be generated and updated based on data received from the air particle counters to facilitate SOP management.
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
Provided are a method, a device and a computer-executable program for early diagnosis of a SARS-CoV-2 infection by means of using a biomarker lymphatic index by volume and monocyte distribution width (MDW). The automated volume parameter lymphatic index and MDW can be used as a viral biomarker to help medical staff in clinics or fever clinics quickly identify a patient who may be infected with SARS-CoV-2 and provide valuable information for triage decisions.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
85.
DETECTION OF MEDICAL CONDITION, SEVERITY, RISK, AND ACUITY USING PARAMETERS
Systems and methods for assessing viral infection are provided. The systems and methods can include characterizing a WBC in a blood sample, and calculating a MDW value for the blood sample. If the MDW value for the blood sample is less than or equal to 20, that indicates that viral infection is unlikely. If the MDW value for the blood sample is greater than or equal to 20, the systems and methods can further include evaluating one or more of percent lymphocytes, a standard deviation for neutrophil LALS, a WBC percent eosinophils, a monocyte index, a mean ALL for monocytes, a standard deviation for monocyte MALS, a monocyte opacity mean, a standard deviation for ALL for monocytes, a WBC percent basophils, LHD, a standard deviation for volume for WBC, a standard deviation for volume for monocytes and neutrophils, or a WBC percent neutrophils.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
The disclosure relates to methods and apparatus for processing fluids through the use of a magnetic assembly wherein the magnetic assembly includes at least one fluid chamber containing a fluid and magnetic particles.
An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.
An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.
A sample preparation instrument with an integrated device for estimating a concentration of white blood cells in a specimen is described. The sample preparation instrument receives a specimen for which a sample is to be prepared for analysis. The integrated device can implement an optical method, an electrical resistance method, or a flow cytometry method, for example, to estimate the white blood cell concentration in the specimen. For some types of analysis, a sample volume of the specimen is dependent on the white blood cell concentration. Therefore, the sample preparation instrument can automatically determine and adjust the sample volume of the specimen based on the estimated white blood cell concentration prior to adding additional reagents, such as labeling reagents and/or lytic reagents, to prepare the sample.
Described herein are method of transferring liquid using a robotic liquid handier from a reagent reservoir having a sloped bottom along a length of the reagent reservoir, the sloped bottom defining a shallow end and a deep end of the reagent reservoir, wherein the shallow end is proximal to a first side-wall of the reagent reservoir, wherein the deep end is proximal to a second side-wall of the reagent reservoir opposite the first side-wall.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
A reaction vessel comprises a lower chamber with a first volume, and an upper chamber with a second volume greater than the first volume. A thermocycling system for heating the reaction vessel includes a lower heating zone to heat the lower chamber, an upper heating zone to heat the upper chamber, and a lid heater to heat an opening of the upper chamber. A method comprises loading a sample into a lower chamber of a reaction vessel, thermocycling the lower chamber using a lower heating zone of the thermo cycler, combining an additive into the sample to produce a combination filling the lower chamber and at least partially filling an upper chamber of the reaction vessel, and incubating the upper and lower chambers using the lower heating zone and an upper heating zone. The lower and upper chambers can have different wall thicknesses to facilitate heat transfer.
A server stores a set of laboratory applications to process batches of samples. The server receives, from a first lab administrator, a selection of a subset of the laboratory applications to process the batches of samples and an admin configuration for a laboratory application in the subset. The server receives configuration(s) of batch(es) to be used for running at least a portion of the subset of laboratory applications configured according to the admin configuration. The server receives, from a first scientific device, a request to run a laboratory application form the first subset to process a batch. The server provides the laboratory application(s) that are capable of being executed using the first scientific device. The server receives, from the first scientific device, a selected laboratory application. The server transmits, to the first scientific device, a signal for executing a first part of the selected laboratory application.
A decapping device may be integrated with an automated biochemical analyzer or biological testing system to aid in sample testing. The exemplary decapper, includes a motor that is operable to lower a latch mechanism to engage with a cap of a sample tube and then raise the latch mechanism to remove the engaged cap. As the latch mechanism is lowered, a retractor portion also descends and causes a set of grippers to extend and grip the sample tube. As the latch mechanism is raised, the set of grippers apply a corresponding pressure to hold the sample tube in place while the cap is removed. Once removed, the cap rests within the latch mechanism and the set of grippers are retracted by the raising retractor. As the latch mechanism returns to its origin position, an ejector arm is operated causing the cap to be ejected from the latch mechanism.
B67B 7/02 - Hand- or power-operated devices for opening closed containers for removing stoppers
B67B 7/18 - Hand- or power-operated devices for opening closed containers for removing threaded caps
B67B 7/14 - Hand- or power-operated devices for opening closed containers for removing tightly-fitting lids or covers, e.g. of shoe-polish tins, by gripping and rotating
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.
C07D 321/00 - Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups
C07D 407/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
C09K 11/07 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
95.
COMPOUNDS FOR THE IDENTIFICATION OF MICROBIAL CLASSES AND USES THEREOF
Described herein are compounds based on the formula X-L-R, wherein X is a recognition element that binds to at least one, but not all three, of a Gram-positive microbe population, a Gram-negative microbe population, and a fungal population, L is a bond or a linker, and R is a reporter or an antibody ligand. These compounds are useful as, among other things, diagnostic agents for identifying a disease state in a subject or identifying a contaminant in or on a sample. Also described herein are compositions containing such compounds and methods of using the compounds and compositions.
The present disclosure relates to a staining methodology employing a particle contrast agent composition. The compositions described herein are capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Basic Fuchsin; at least one of Brilliant Cresyl Blue, Azure B, Crystal Violet and New Methylene Blue; one or more permeabilizing agents; and Gluteraldehyde.
Systems and methods of identifying reagents loaded into a fluid handling system can comprise programming a protocol for preparing a sample into a controller of the fluid handling system, loading multiple reagent vessels into a carousel of the fluid handling system, imaging individual labels of the multiple reagent vessels with an imaging device to produce label images, comparing information in the label images to identification information located in a database in communication with the controller, and determining if appropriate reagents have been loaded into the carousel to perform the protocol. A fluid handling system can include a deck, a tube holder, an imaging device, a pipettor, a non-transitory computer-readable storage medium and a processor configured to perform the method.
A biological sample test system and method includes a remote sample delivery system, configured to secure a container for a biological sample, the container including a sample identifier. A sample receiving station is configured to receive the container from the remote sample delivery system based on the sample identifier. The remote sample delivery system is configured to automatically navigate to the sample receiving station upon the container being secured to the remote sample delivery system. A sample test track, comprising a plurality of test stations and a container conveyance system configured to sequentially deliver the container to individual ones of the plurality of test stations based, at least in part, on sample identifier.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 1/00 - Sampling; Preparing specimens for investigation
99.
SYSTEMS AND METHODS FOR LABORATORY DECK SETUP VERIFICATION
A laboratory workstation for preparing a sample according to a programmed protocol. The laboratory workstation may include a display device configured to display an instruction for loading a first item of labware onto a deck of the laboratory workstation at a position on the deck specified by the programmed protocol; an imaging device configured to monitor the deck of the laboratory workstation by creating one or more images of the deck; and a processor configured to recognize, in the one or more images created by the imaging device, an item of labware loaded onto the deck by an operator. In some embodiments, the processor may be configured to indicate on the display device whether the recognized item of labware loaded by the operator is arranged on the deck in accordance with the programmed protocol.
Methods and systems for detecting and reporting subpopulations of neutrophils may involve using a nonce parameter to elucidate one or more other cell population parameters. Methods and systems for detecting and reporting subpopulations of neutrophils may involve structuring reports to elucidate one or more cell population parameters, particularly, but not exclusively, where the report of a cell population parameter might otherwise be ambiguous or a higher than usual likelihood of confusion.
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