The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Lysis reagents for sample preparation, used in analysis for scientific and research purposes
(2) Lysis reagents for sample preparation, used in analysis for in vitro diagnostic use
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Lysis reagents for sample preparation, used in analysis for scientific and research purposes. Lysis reagents for sample preparation, used in analysis for in vitro diagnostic use.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Lysis reagents for sample preparation, used in analysis for scientific and research purposes Lysis reagents for sample preparation, used in analysis for in vitro diagnostic use
Systems and methods for analyzing flow cytometry particles. A flow cytometry system is configured to direct a fluid stream of particles through an interrogation location, and includes a laser configured to emit light toward the interrogation location to produce light signals from the particles, and one or more detectors configured convert the light signals to waveform data. The flow cytometry system includes a waveform acquisition device to continuously digitize the waveform data, and a graphics processing unit configured to apply one or more adjustable threshold voltages to the digitized waveform data to extract event data for the particles.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The disclosure relates to a substrate comprising a micro- or nanostructured periodic array comprised of a plurality of anisotropic metallic micro- or nanostructures, wherein each of the plurality of nanostructures induce an average maximum and substantially uniform plasmonic field greater than 108 across the substrate; a plurality of Raman-active linker molecules directly bound to the metallic micro- or nanostructures; and a plurality of capture molecules directly bound to the Raman-active linker molecules. The disclosure also relates to systems, devices, and methods that use the substrates to determine the concentration of various analytes.
Systems and methods for calibrating laboratory instruments. In an example, a laboratory instrument for testing patient specimens includes a testing apparatus configured to receive a cassette that includes a patient specimen or a quality control specimen. In response to determining that a quality control specimen is present, the instrument obtains a first measurement of a parameter. If the first parameter is outside an expected tolerance, the instrument ceases performing tests on all specimens, the instrument re-tests the quality control specimen to obtain a second measurement of the parameter. If the second measurement is within the expected tolerance, instrument resumes processing of the cassette. If the second measurement is outside the expected tolerance, the instrument indicates that recalibration or service is required.
The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device. The system includes: a first laser source configured to emit a first laser beam to a liquid flow of a sorting device, the first laser beam and the liquid flow intersecting at a first laser interrogation point located in a nozzle system of the sorting device; a second laser source configured to emit a second laser beam to the liquid flow, the second laser beam and the liquid flow intersecting at a second laser interrogation point located outside the nozzle system; a first detector and a second detector which are respectively used for detecting emission, in response to the first laser beam and the second laser beam, of a particle in the liquid flow; and a droplet delay time calculation unit configured to calculate, on the basis of the time when the particle in the liquid flow passes through the first laser interrogation point and the time when the particle passes through the second laser interrogation point, a first delay time for the liquid flow flowing from the first laser interrogation point to the second laser interrogation point, and calculate, on the basis of the first delay time, a droplet delay time.
The present disclosure relates to a nozzle for a sample processor, a carrier of a nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a detachable manner. The orifice is provided in the body and is configured to inject a sample from an injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and the sample processor according to the present disclosure include the above-described nozzle and carrier. With the aid of the carrier, it is not necessary to install the nozzle to the injector body upstream of the nozzle, so that various adjustment operations when reinstalling the nozzle can be omitted, thereby simplifying the process of reinstalling the nozzle.
A system comprises: a sample analyzing device reading measurements associated with a liquid sample; a display device displaying a graphical user interface (GUI) to a current user of the automated sample analyzer; processing circuitry; and a memory storing: a receiving engine which receives the measurements associated with the liquid sample from the sample analyzing device and storing the received measurements in memory; a configuration control engine which sets a configuration of a user model to correspond to the current user of the automated sample analyzer; a learning engine which detects and collect at least one pattern of interaction of the current user with the GUI; and a user interface engine which configures the GUI according to user-dependent configuration data of the configuration of the user model corresponding to the current user.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
15.
DHNT MONOMERS AND POLYMER DYES WITH MODIFIED PHOTOPHYSICAL PROPERTIES
The present disclosure relates to dihydronaphthothiophene (DHNT), dihydrobenzodithiophene (DHBDT), and dihydronapthothienothiophene (DHNTT) monomer units and fluorescent polymers and co-polymers thereof. DHNT, DHNTT, and/or DHBDT containing water-soluble fluorescent co-polymers, water-soluble tandem fluorescent co-polymers, water-soluble fluorescent co-polymer complexes, water-soluble tandem fluorescent co-polymer complexes, and their use in methods for detecting analytes in a biological sample are also provided.
An aperture device for a flow cytometer is described. The aperture device includes a first aperture, and a second aperture spaced apart from the first aperture by a distance. The distance between the first and second apertures and a size of the first and second apertures are adjustable to create an optimal light intensity fringe pattern for analyzing a particle having a preselected type or characteristic at an interrogation zone of the flow cytometer.
Compositions, methods, and kits for stable Trypan Blue solutions are provided. In one example, a method includes: cooling a solution of Trypan Blue; and filtering the cooled solution. In another example, a method includes: mixing a water-soluble polymer with a Trypan Blue solution. The method may further include adding one or more ingredients such as an aqueous buffer, an osmolyte, an acid, a base, a buffer, a cell culture medium, water, or combinations thereof.
An external calibration curve relies on external calibrators containing known concentrations of a target analyte that can deteriorate over time, leading to inaccurate results. Generating new calibration curves often requires preparing several calibrators to obtain calibration points needed for generating the calibration curves. Preparing the calibrators necessary for multi-point calibration curves requires operator preparation time and can introduce handling errors. The presently claimed and described technology provides a clinical laboratory automation system, including a fluid handling system, an analyzer component, and a mass spectrometer. The clinical laboratory automation system can provide automated calibration using one calibrator to prepare one or more calibrator dilutions used to generate a calibration curve for the quantitative measurement of a target analyte in a sample. The clinical laboratory automation analyzer may also provide an automated evaluation of pipettor dispensing volume and adjustment of the pipettor actuator to deliver an accurate dispensing volume.
A considerable amount of time is required for calibration and compliance service for electrolyte measuring devices with ion selective electrode analyzers in most clinical or diagnostic laboratory settings. Often a user has to make trade-offs between improving diagnostic accuracy and processing higher workloads faster and more predictably. Current electrolyte measuring devices with ion selective electrodes are unable to balance the increased requirements for accuracy and speed. The presently claimed and described technology provides an improved device for an ion selective electrode analyzer. The presently claimed and described technology also provides methods for simultaneous and selective washing of components of the ion selective electrode analyzer and methods for simultaneous and selective analysis of samples using the ion selective electrode analyzer in an automated chemical analyzer.
A computer implemented method, a computing device, a laboratory instrument, a computer program product and a computer readable storage medium for selectively de-ide ntifying protected health information (PHI) are provided. The method comprises accessing a first data file, the first data file comprising at least a first data item, wherein the first data item comprises PHI and first PHI category information, wherein the first PHI category information is indicative of a first PHI category of a plurality of PHI categories, the PHI in the first data item belonging to the first PHI category. The method further comprises accessing the first PHI category information. The method further comprises assessing, based on the first PHI category information, whether the PHI in the first data item is to be de-identified or not. If the PHI in the first data item is to be de-identified, the method further comprises generating a second data item by modifying the first data item such that the protected health information is de-identified.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Disclosed are dispensers (100, 200, 300) and methods for dispensing and degassing a liquid (102). The dispensers and methods may include a heater (308) and a first tube (124, 502) constructed of a first material. The first tube may include a first end (124A) operable to be connected to a source (104) of the liquid and a second end (124B). The first tube may be connected to the heater via a conductive pathway thermally connecting the heater to the first tube. The first material may have a permeability such that a portion of the gas dissolved in the liquid passes through the first material to an atmosphere upon being degassed from a portion of the liquid within the first tube (124, 502).
The disclosure relates to conjugates of the formulae (I) and (II): wherein the variables R1, R2, R3, R17, R18, R19, R20, R20A, R21, and G are defined herein, as well as methods for the use of the conjugates, and kits including the conjugates.
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
A61K 39/385 - Haptens or antigens, bound to carriers
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
C07J 1/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C07J 3/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by one carbon atom
C07J 5/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
23.
SYSTEMS AND METHODS FOR EVALUATING IMMUNE RESPONSE TO INFECTION
Systems and methods for characterizing immune response to infection using cellular analysis, such as a hematological cellular analyzer. In some instances, the immune response may be characterized as normal or abnormal based on one or more blood cell population parameters. In some instances, abnormal characterization may be used to identify patients with sepsis or at elevated risk of developing sepsis.
The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
A chemistry analysis machine and method for using the machine include adding heating functionality to provide faster test specimen heating times or comparable specimen heating times while using containers or cuvettes made of materials such as plastic that have lower thermal conductivity. In one example, a mixing bar is heated prior to contacting the test specimen within the container to provide the additional heating capability to the system. In one example where the mixing bar is heated, a heater is added to the system to heat the rinse water used to rinse the mixing bar after it is washed and prior to its next use in contacting a test specimen.
Summarising the invention, a device is provided. The device comprises a dispensing component configured to draw and dispense liquid, wherein the dispensing component is movable with respect to a liquid sample; and a capacitive sensing component coupled to the dispensing component and configured to detect a plurality of operational states of the dispensing component, wherein each operational state of the plurality of operational states corresponds to a respective capacitance value of a plurality of capacitance values; wherein: the capacitive sensing component has a capacitive sensing range, wherein the capacitive sensing range is a predefined working range for the capacitive sensing component; and the capacitance of at least part of the device is adapted to the capacitive sensing range such that each capacitance value of the plurality of capacitance values is within the capacitive sensing range.
Maturity of a cell may be detected using a computer-implemented image analysis method which comprises capturing an image of a stained blood cell with a camera and then determining maturity for the stained blood cell. This determination may include classifying the stained blood cell before generating the stained blood cell's maturity. Corresponding systems may also be implemented, and approaches used for determining maturity of a cell may be used for detecting other characteristics, such as infection by malaria or other parasite.
A biological analyzer system includes a biological analyzer, a fluid routing system, and a first linear peristaltic pump. The biological analyzer is configured to analyze a biological sample. The fluid routing system is configured to direct the biological sample into the biological analyzer. The first linear peristaltic pump is configured to move the biological sample in the fluid routing system. The first linear peristaltic pump includes a first hollow flexible tubing, a first actuation assembly, and a first tubing compression member. The first hollow flexible tubing extends along a first longitudinal axis. The first hollow flexible tubing is in fluid communication with the fluid routing system. The first tubing compression member is configured to move relative to the first hollow flexible tubing along a predetermined path in response to an input from the first actuation assembly to advance fluid within the first hollow flexible tubing along the first longitudinal axis.
A system performs a non-destructive measurement of a density gradient to automatically replicate and dispense the density gradient. The system obtains measurements at points along a length of the density gradient and generates a profile of the density gradient based on the measurements. The system uses the profile to replicate the density gradient of components in a second container. The system inserts a distal end of a probe into the second container, and pumps separate components into a manifold and mixing chamber connected to a proximal end of the probe to automatically dispense the density gradient in the second container.
G01N 9/24 - Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
G01N 9/30 - Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity by using centrifugal effects
30.
CHEMILUMINESCENT REAGENTS FOR DETECTION OF ALKALINE PHOSPHATASES
Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.
A biological imaging analyzer comprises a staining module configured to produce stained cells. The staining module comprises one or more chambers configured to receive a biological sample and a staining composition, and a heater configured to heat the biological sample and the staining composition. The analyzer also comprises a lighting module configured to illuminate the stained cells, and an imaging module configured to capture images of the stained cells. A method of staining a biological sample comprises depositing the staining composition into the one or more chambers, and pre-heating the staining composition in the one or more chambers. The method also comprises depositing the biological sample into the one or more chambers, and heating the biological sample and the staining composition in the one or more chambers.
A biological imaging analyzer comprises a flowcell configured to flow biological cells therethrough, the flowcell including an imaging region where images of the biological cells are captured. The analyzer also comprises a lighting module configured to generate a light, the lighting module comprising a light guide configured to convey the light to an imaging region of the flowcell. The analyzer further comprises an imaging module configured to capture images of the biological cells at the imaging region of the flowcell. The analyzer also comprises a flowcell holder in operable connection with the flowcell. A method of positioning a flowcell for biological analysis comprises providing the flowcell configured to flow a biological sample for analysis, and operably connecting the flowcell holder with the flowcell.
A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.
A biological imaging analyzer comprises a staining module configured to produce stained cells. The staining module comprises one or more chambers configured to receive a biological sample and a staining composition, and a heater configured to heat the biological sample and the staining composition. The analyzer also comprises a lighting module configured to illuminate the stained cells, and an imaging module configured to capture images of the stained cells. A method of staining a biological sample comprises depositing the staining composition into the one or more chambers, and pre-heating the staining composition in the one or more chambers. The method also comprises depositing the biological sample into the one or more chambers, and heating the biological sample and the staining composition in the one or more chambers.
A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.
Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A biological imaging analyzer comprises a flowcell (22) configured to flow biological cells therethrough, the flowcell including an imaging region where images of the biological cells are captured. The analyzer also comprises a lighting module configured to generate a light, the lighting module comprising a light guide configured to convey the light to an imaging region of the flowcell. The analyzer further comprises an imaging module (24) configured to capture images of the biological cells at the imaging region of the flowcell. The analyzer also comprises a flowcell holder in operable connection with the flowcell. A method of positioning a flowcell for biological analysis comprises providing the flowcell configured to flow a biological sample for analysis, and operably connecting the flowcell holder with the flowcell.
The presently claimed and described technology provides integrated automated instruments (100, 100A, 100B, 100C) and methods (800) for automatically processing a whole blood sample (50) in a single sample tube (80). These include: mixing the sample in the tube; analyzing a portion (50P) of the mixed sample (50M); centrifuging the sample in the tube thereby separating plasma (60); and analyzing a portion (60P) of the plasma. A pretreatment module (200) may mix, centrifuge, transport, and store the sample. The integrated instrument may include multiple detector components and does not require external sample handling.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
40.
ADDITIVES FOR REDUCING NON-SPECIFIC INTERACTIONS BETWEEN FLUORESCENT POLYMER CONJUGATES AND CELLS IN A BIOLOGICAL SAMPLE
The disclosure relates to methods and compositions for reducing or eliminating non-specific binding of at least one dye conjugate to cells in a biological sample. A dye conjugate is contacted with at least one zwitterionic or anionic surfactant before, during or after the dye conjugate is contacted with a blood sample, resulting in substantially reduced non-specific binding of the dye conjugate to cells in the biological sample.
C08G 61/10 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
This disclosure provides improved assays and assay methods that include compositions comprising enzymes, such as ALP, conjugated to an antigen or antibody, as well as compositions that include enzyme substrates, wherein the compositions are optimized and adapted to provide improved assay performance. The disclosure also describes compositions of matter and kits that comprise the compositions for use in immunoassays.
A system (100, 100', 100") is provided for an automated analyzer (10) having an analyzer arrangement (12) configured to consume liquid consumables (14). The liquid consumables (14) are delivered to the automated analyzer (10) via consumables containers (20). The system (100, 100', 100") comprises a consumables container loading/unloading unit (102) comprising at least a first container holding position (Cl) and a second container holding position (C2). Each of the first container holding position (C1) and the second container holding position (C2) is configured to removably hold at least one of the consumables containers (20). The system (100, 100', 100") further comprises at least one operator accessible container station (104) accessible by an operator, such that at least one of the first container holding position (Cl) and the second container holding position (C2) is configured to directly receive the consumables containers (20) at the at least one operator accessible container station (104) from the operator. The system (100, 100', 100") further comprises at least one analyzer supply station (106) configured to deliver the liquid consumables (140 to the automated analyzer (10).
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
43.
NOVEL FLUORESCENT DYES AND POLYMERS FROM DIHYDROPHENANTHRENE DERIVATIVES
The present disclosure provides novel dihydrophenanthrene (DHP)-cyanine and DHP-squaraine fluorescent compounds and water-soluble polymers thereof. The DHP- cyanine and DHP-squaraine fluorescent compounds and polymers can be excited using UV, violet, blue, yellow, green, red, or NIR wavelengths. The fluorescent dyes may be conjugated to antibodies for detection of target analytes in biological samples and are suitable for use in flow cytometry analyses.
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
C09B 69/10 - Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
44.
CALIBRATION AND VALIDATION OF CUVETTES IN AUTOMATED CHEMICAL ANALYZERS
The presently claimed and described technology provides improved calibration and validation procedures for sample containers (e.g., cuvettes) in automated chemical analyzers. The claimed and described technology further provides methods of operating an automated analyzer that allows for the automation of calibrating and tracking the integrity of individual sample containers (e.g., cuvettes) in parallel with measuring constituent samples. These methods eliminate the need to alternate between a diagnostic mode and measurement mode when performing system maintenance, such as validating cuvette integrity, calibrating absorbance baseline, and replacing cuvettes. As such, the presently claimed and described technology can reduce downtime and improve the clinical lab productivity significantly by allowing for this system maintenance to occur simultaneously with sample analysis.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 21/90 - Investigating the presence of flaws, defects or contamination in a container or its contents
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
45.
METHOD AND INSTRUMENT FOR DRAWING A VOLUME OF A BIOLOGICAL SAMPLE FOR TESTING
Summarizing the invention, a method is provided. The method comprises: accessing test order data, wherein the test order data comprise information specifying a set of clinical tests to be carried out on a biological sample, wherein the set of clinical tests comprises at least a clinical test and the biological sample is contained in a sample container; obtaining test volume data by using the test order data, wherein the test volume data comprise information specifying a test volume; and instructing a pipetting device of a laboratory instrument to draw a drawing volume of the biological sample from the sample container, the drawing volume being based on the test volume data; wherein the test volume is the volume of the biological sample needed to carry out: the clinical test, and one or more supplementary tests associated with the clinical test, whenever one or more test volume conditions associated with the clinical test are met, wherein the one or more test volume conditions comprise a condition that one or more rules require that the one or more supplementary tests shall be carried out whenever one or more supplementary test conditions on the clinical test are met.
G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The present disclosure provides a sample handling arrangement (100, 100', 100'') for transferring one or more patient samples or portions thereof from at least one sample tube (20) to at least one reaction vessel (22) within an automated analyzer (50, 50'). The sample handling arrangement (100, 100', 100'') includes a sample presentation unit (102) associated with the automated analyzer (50) and configured to receive a plurality of racks (26) into the automated analyzer (50). Each of the plurality of racks (26) is configured to receive and hold the at least one sample tube (20). The sample handling arrangement (100, 100', 100'') further includes a linear slide (114) configured to be selectively mounted to a mount of the automated analyzer (50) at a first position (Pl) and a second position (P2) different from the first position (P2). The sample handling arrangement (100, 100', 100'') further includes a pipetting module (112) configured to travel along the linear slide (114) and transfer the one or more patient samples or portions thereof to the at least one reaction vessel (22) within the automated analyzer (50, 50').
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
47.
ANTIMICROBIC SUSCEPTIBILITY TESTING USING RECURRENT NEURAL NETWORKS
An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use on a sample. This may include iteratively imaging wells inoculated with the sample and containing various concentrations of the antimicrobic. The images are thereafter processed to identify MIC based on sequences in information provided as input to a machine learning model.
C12Q 1/18 - Testing for antimicrobial activity of a material
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
48.
INTEGRATED SAMPLE PROCESSING SYSTEM WITH VARIABLE WORKFLOWS
One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.
A middleware device or software may be placed in communication with one or more testing instruments and a lab information system. As samples are collected from patients and tested with the testing instruments, test results pass through the middleware and are analyzed in context with other data, such as patient history, testing instrument history, and test results from other tests of the sample, in order to determine whether a particular result is acceptable, whether retesting is needed, whether additional sample collection or testing is needed, and whether currently ordered testing is still necessary. When the middleware determines a need for additional testing or retesting it may automatically create orders for such testing in order to reduce delays in manual review of testing results.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.
A pipetting instrument for loading and dispensing a sample is described. The pipetting instrument includes an automated liquid pipettor having a deck for supporting a pipette tip box comprising pipette tips, and mandrels for engaging the pipette tips and withdrawing at least some of the pipette tips from the pipette tip box. The pipetting instrument further includes a controller configured to control the automated liquid pipettor, the controller further configured to execute a pipette tip dislodging operation to dislodge any undesired pipette tips that are withdrawn from the pipette tip box using the mandrels.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable and recorded software for clinical decision support; Downloadable and recorded software for providing medical and wellness information to a clinician; Downloadable and recorded software for data analysis and clinical decision support for health care; Downloadable and recorded software using artificial intelligence for data analysis and clinical decision support for health care; Downloadable and recorded computer software using artificial intelli-gence for managing and analyzing data from laboratory and diagnostic instruments; Downloadable and recorded software for pro-actively managing patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Downloadable and recorded software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Downloadable and recorded software for predicting patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access. Providing online non-downloadable software for clinical decision support; Providing temporary use of non-downloadable software for providing medical and wellness information to a clinician; Providing on-line non-downloadable software for data analysis and clinical decision support for health care; Software as a service (SAAS) services featuring software using artificial intelligence for data analysis and clinical decision support for health care; Providing online non-downloadable software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; Platform as a service (PAAS) featuring computer software platforms to pro-actively manage patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Providing non-downloadable cloud-based computer software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Provision of non-downloadable cloud-based computer software application that predicts patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access. Providing medical information collected from clinical decision support software; Providing medical health assessments using clinical decision support software; Maintaining personal medical histories, files, treatments and analyses collected using clinical decision support software.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable and recorded software for clinical decision support; Downloadable and recorded software for providing medical and wellness information to a clinician; Downloadable and recorded software for data analysis and clinical decision support for health care; Downloadable and recorded software using artificial intelligence for data analysis and clinical decision support for health care; Downloadable and recorded computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; Downloadable and recorded software for pro-actively managing patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Downloadable and recorded software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Downloadable and recorded software for predicting patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access Providing online non-downloadable software for clinical decision support; Providing temporary use of non-downloadable software for providing medical and wellness information to a clinician; Providing on-line non-downloadable software for data analysis and clinical decision support for health care; Software as a service (SAAS) services featuring software using artificial intelligence for data analysis and clinical decision support for health care; Providing online non-downloadable software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; Platform as a service (PAAS) featuring computer software platforms to pro-actively manage patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Providing non-downloadable cloud-based computer software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Non-downloadable cloud-based computer software application that predicts patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access Providing medical information collected from clinical decision support software; Providing medical health assessments using clinical decision support software; Maintaining personal medical histories, files, treatments and analyses collected using clinical decision support software
55.
METHODS FOR EVALUATING MIS-C ASSOCIATED WITH COVID-19
Systems and methods for identifying Multisystem Inflammatory Syndrome in Children (MIS-C) may use various hematological parameters and combinations of hematological parameters. Such parameters and combinations may use monocyte distribution width (MVDW), though other parameters may also be used. Using this approach, area under curve values of 0.8 or greater may be achieved. Such parameters may also be used in treatment of MIS-C, including evaluation of status of hospitalized patients to determine when such patients may be safely discharged.
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
An aspect of the present invention relates to a computer-implemented method comprising the steps of: obtaining, from or by a first computing device, log data, the log data comprising a first plurality of log data items; and obtaining anomaly data, the anomaly data comprising information indicative of the presence of an anomaly in a laboratory instrument, wherein the first computing device is configured to access a log file of the laboratory instrument, the log file comprising a first plurality of log file entries, each log file entry of the first plurality of log file entries comprising a plurality of fields, and to construct the log data, by, for each log data item of the first plurality of log data items: selecting first field-data of a first field of a respective log file entry, the first field of the respective log file entry specifying a respective event which has occurred in the laboratory instrument; selecting second field-data of a second field of the respective log file entry, the second field of the respective log file entry further describing the respective event occurred in the laboratory instrument, wherein the selecting of the respective second field is based on the first field-data of the respective first field of the respective log file entry; and constructing said each log data item by using the first field-data of the first field of the respective log file entry and the second field-data of the second field of the respective log file entry. Additional aspects of the present invention relate to further computer-implemented methods, a data processing system, a laboratory instrument, an automated laboratory system, a computer program product, and a computer-readable medium.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A detection system for a flow cytometer includes a light source configured to generate an excitation light beam. A suppression element has a first portion having a first characteristic, and a second portion surrounding the first portion. One or more differences between the first and second characteristics cause a phase shift between light fringes and a high intensity core of the excitation light beam resulting in suppression of the light fringes.
A server stores a set of laboratory applications to process batches of samples. The server receives, from a first lab administrator, a selection of a subset of the laboratory applications to process the batches of samples and an admin configuration for a laboratory application in the subset. The server receives configuration(s) of batch(es) to be used for running at least a portion of the subset of laboratory applications configured according to the admin configuration. The server receives, from a first scientific device, a request to run a laboratory application form the first subset to process a batch. The server provides the laboratory application(s) that are capable of being executed using the first scientific device. The server receives, from the first scientific device, a selected laboratory application. The server transmits, to the first scientific device, a signal for executing a first part of the selected laboratory application.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; panels of reagents, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemiluminescent reagents, for scientific and research use. Chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtiter plates, for medical use; chemiluminescent reagents, for medical use. Analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, pipette tips, probes, well plates; laboratory consumables for scientific and research use, namely, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids. Apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; panels of reagents, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemiluminescent reagents, for scientific and research use Chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtiter plates, for medical use; chemiluminescent reagents, for medical use Analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, pipette tips, probes, well plates, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids Apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable and recorded software for clinical decision support; Downloadable and recorded software for providing medical and wellness information to a clinician; Downloadable and recorded software for data analysis and clinical decision support for health care; Downloadable and recorded software using artificial intelligence for data analysis and clinical decision support for health care; Downloadable and recorded computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; Downloadable and recorded software for pro-actively managing patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Downloadable and recorded software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Downloadable and recorded software for predicting patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access Providing online non-downloadable software for clinical decision support; Providing temporary use of non-downloadable software for providing medical and wellness information to a clinician; Providing on-line non-downloadable software for data analysis and clinical decision support for health care; Software as a service (SAAS) services featuring software using artificial intelligence for data analysis and clinical decision support for health care; Providing online non-downloadable software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; Platform as a service (PAAS) featuring computer software platforms to pro-actively manage patient health information for chronic and acute conditions in a community for use by mobile health workers, community health workers, health navigators, care managers, case managers; Providing non-downloadable cloud-based computer software for use as an emergency department triage support tool to improve triage accuracy by analyzing patient data and calculating patient health related triage information to support a health care professional's decision making; Non-downloadable cloud-based computer software application that predicts patients' risk of appointment no-show, directing targeted outreach and smart over-booking strategies to increase outpatient access Providing medical information collected from clinical decision support software; Providing medical health assessments using clinical decision support software; Maintaining personal medical histories, files, treatments and analyses collected using clinical decision support software
62.
COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR PROCESSING AND/OR TESTING OF A BIOLOGICAL SAMPLE
An aspect of the present invention relates to a computer-implemented method, the method comprising at least the steps of: obtaining, by a first computing device, sample location data, the sample location data comprising information indicative of a sample location of a biological sample; obtaining, by the first computing device, test data, the test data comprising information indicative of one or more clinical tests to be performed on the biological sample; selecting by evaluating laboratory data, by the first computing device, a processing laboratory from a first plurality of laboratories, wherein the processing laboratory is located at a processing laboratory location and the processing laboratory comprises one or more laboratory instruments, the one or more laboratory instruments being configured to carry out the one or more clinical tests to be performed on the biological sample; and instructing, by the first computing device, an agent to initiate a transfer of the biological sample from the sample location to the processing laboratory location. Further aspects of the present invention relate to another computer-implemented method, a computer program product and a system.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
Embodiments of the present disclosure relate to a method, system and apparatus for setting a clotting time for a blood sample contained in a container in a laboratory device or test system, which includes setting a clotting start time for the blood sample, setting a clotting wait time to allow for the blood sample to clot, and on positive determination of the completion of the clotting wait time, automatically providing the blood sample for further processing in the laboratory.
Improved user interfaces for assisting in form completion (and/or systems, apparatuses, methods, and/or computer program products that present such improved user interfaces) store data for incomplete forms for people, such as the ASCVD (atherosclerotic cardiovascular disease) risk score questionnaire and/or other questionnaires and/or forms, and remind the people regarding incomplete information while providing assistance in obtaining the incomplete information. In some examples, the reminders and/or assistance may be provided via one or more chatbots. In various examples, the assistance may be tailored for the people using information stored about the people.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
65.
LIGHT DETECTING SYSTEM AND LIGHT DETECTING METHOD FOR FLOW CYTOMETER
A light detecting system and a light detecting method for a flow cytometer are provided. The light detecting system includes a beam separating device and multiple wavelength division multiplexing devices. The beam separating device is configured to separate a beam to be processed by the flow cytometer into multiple first beams having respective wavelength ranges that either do not overlap with each other or partially overlap with each other. Each of the multiple wavelength division multiplexing devices is configured to receive a respective one of the multiple first beams. The multiple first beams are parallel to each other when received by the multiple wavelength division multiplexing devices. Each of the multiple wavelength division multiplexing devices includes multiple light detecting devices being configured to detect a portion of the respective first beam.
The disclosure relates to, among other things, an automated flow cytometric method and system for the analysis and enumeration of at least one of hematopoietic stem cells, hematopoietic progenitor cells, and T-cells.
A method of framing a workspace for a working tool of a robotic fluid handler comprises positioning a liquid dispenser within a workspace of the robotic fluid handler using a transport device, moving the liquid dispenser to a general location of a component of the workspace, contacting the liquid dispenser to multiple features of the component, determining a specific location for the general location based on contacting of the liquid dispenser to the multiple features, and registering the specific location to the workspace.
A microscope imaging system includes an objective (18) configured to collect light from a biological sample (S) for forming a magnified image of the biological sample. The microscope imaging system also includes a camera (14) including an imaging sensor. The imaging sensor is configured to detect the magnified image of the biological sample. The microscope imaging system further includes a tube lens (16) positioned between the objective and the camera. The tube lens is configured to project the magnified image of the biological sample onto the imaging sensor of the camera. The tube lens is spaced apart from the imaging sensor of the camera by a distance (D2) less than a focal length of the tube lens.
The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.
An analyzer may have its operation validated using control samples which comprise synthetic particles. Such an analyzer be adapted to obtain a representation of a particle from a sample and obtain a classification of the particle which classifies the particle as a type specific to control samples. The analyzer may also be adapted to perform control specific processing on the sample, and to generate an analysis output for the sample based on a result of the control specific processing.
An automated analysis instrument operates to detect inadequate dispensation of a fluidic substance on a tray. The instrument includes an image capturing device to capture an image of at least a portion of the tray including a receptacle portion and a surrounding portion around the receptacle portion. The instrument then identifies the surrounding portion of the at least the portion of the tray in the image, evaluates color components of the image corresponding to the surrounding portion of the at least the portion of the tray, and determines whether the fluidic substance is present on the surrounding portion of the at least the portion of the tray based on at least one of the color components.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
A full line of chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents for use in genetic research; genomic reagents, for scientific and research use; flow cytometry reagents, for scientific and research use; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; reagents for use in particle size analysis and characterization, for scientific and research use; panels of reagents, for scientific and research use; laser excitable dyes, for scientific and research use; fixable viability dyes, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemical reagents containing magnetic beads for the isolation, purification, and extraction of DNA and RNA, for scientific and research use; nucleic acid isolation and purification kits consisting primarily of reagents and magnetic beads, for scientific and research use; lysing reagents, for scientific and research use; chemiluminescent reagents, for scientific and research use A full line of chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; reagents for use in flow cytometry, for medical purposes; lysing reagents, for medical purposes; biological tissue, namely, animal cells, tissues, and blood, for medical purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtitre plates, for medical use; chemiluminescent reagents, for medical use A full line of analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; laboratory sample preparation instruments; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; bioreactors for laboratory use; automated laboratory equipment for cell culturing; air particle counters; multi-parameter biological cell sorter instruments, for scientific and research use; centrifuges; centrifuge rotors; flow cytometers; total organic carbon analyzers, for scientific and research purposes; instruments for particle sizing, counting, and analysis; microparticle processor apparatus and instruments, for scientific and research purposes; apparatus and instruments for nucleic acid cleanup and purification; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, setting up experiment protocols, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory centrifuge buckets and adapters, automated lab positioners, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, laboratory storage devices in the nature of cap mats, laboratory plate seal rollers and seals therefor, well plates, reagent and solvent reservoirs, pipette tips, probes, laboratory cassettes for specimen processing and storage, cell culture flask adapters, disposable plastic bioreactors for cell culturing, well plates, microfluidic plates, lids for well plates, lids for microfluidic plates, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids A full line of apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses; flow cytometers, for medical diagnostic uses Online retail store services featuring laboratory apparatus and instruments and their parts, fittings, and accessories therefor and software sold therewith, reagents and chemical preparations, and laboratory consumables; business consulting and advisory services for laboratories, clinics, healthcare providers and related businesses to improve laboratory processes, quality, performance, productivity, efficiency, reduce waste and reduce costs; business consulting services, namely, evaluation of laboratory workflows and processes to improve quality, performance, and efficiency; business efficiency advice for laboratories, clinics, healthcare providers and related businesses Repair and maintenance of laboratory equipment and diagnostic instruments Providing training in the use of laboratory equipment and diagnostic instruments; training for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency; conducting workshops and seminars for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency Scientific research; scientific analysis of data; laboratory analysis in the field of medicine, namely, analysis of chemical markers; consulting services in the field of laboratory operation and automation; consulting services in the field of laboratory testing, diagnostics, and laboratory processes and standards; research in the field of laboratory equipment and instruments; product development for laboratory and diagnostic equipment; technical support services in the nature of troubleshooting of problems with laboratory apparatus and instruments; providing technical support in the nature of technical advice in the operation of laboratory apparatus and instruments; Software as a service (SAAS) services featuring software for uploading, managing, analyzing, sharing, and preserving data related to scientific research and medical diagnostic testing; software as a service (SAAS) services featuring software for automating and optimizing workflow operations, for workflow management for laboratories, and electronic data interchange (EDI); providing temporary use of non-downloadable medical analysis software for use in patients diagnostics; providing temporary use of non-downloadable cloud-based software for assisting hospitals and medical laboratories in clinical, financial reimbursement decisions, inventory management, sample scheduling, and laboratory management and regulatory reporting; software as a service (SAAS) services featuring software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; software as a service (SAAS) services featuring software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; software as a service (SAAS) services featuring software for data analysis for laboratory, scientific, research, and medical use; software as a service (SAAS) services featuring artificial intelligence software for managing and analyzing data from laboratory and diagnostic instruments; software as a service (SAAS) services featuring laboratory middleware software; software as a service (SAAS) services featuring software for clinical decision support Medical information; providing healthcare information; providing medical testing information; analysis and development of medical diagnostic tests; providing medical information to medical professionals in the form of biomedical data; providing personalized healthcare and medical information in the form of biomedical data; medical diagnostic reporting services
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
A full line of chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents for use in genetic research; genomic reagents, for scientific and research use; flow cytometry reagents, for scientific and research use; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; reagents for use in particle size analysis and characterization, for scientific and research use; panels of reagents, for scientific and research use; laser excitable dyes, for scientific and research use; fixable viability dyes, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemical reagents containing magnetic beads for the isolation, purification, and extraction of DNA and RNA, for scientific and research use; nucleic acid isolation and purification kits consisting primarily of reagents and magnetic beads, for scientific and research use; lysing reagents, for scientific and research use; chemiluminescent reagents, for scientific and research use A full line of chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; reagents for use in flow cytometry, for medical purposes; lysing reagents, for medical purposes; biological tissue, namely, animal cells, tissues, and blood, for medical purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtitre plates, for medical use; chemiluminescent reagents, for medical use A full line of analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; laboratory sample preparation instruments; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; bioreactors for laboratory use; automated laboratory equipment for cell culturing; air particle counters; multi-parameter biological cell sorter instruments, for scientific and research use; centrifuges; centrifuge rotors; flow cytometers; total organic carbon analyzers, for scientific and research purposes; instruments for particle sizing, counting, and analysis; microparticle processor apparatus and instruments, for scientific and research purposes; apparatus and instruments for nucleic acid cleanup and purification; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, setting up experiment protocols, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory centrifuge buckets and adapters, automated lab positioners, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, laboratory storage devices in the nature of cap mats, laboratory plate seal rollers and seals therefor, well plates, reagent and solvent reservoirs, pipette tips, probes, laboratory cassettes for specimen processing and storage, cell culture flask adapters, disposable plastic bioreactors for cell culturing, well plates, microfluidic plates, lids for well plates, lids for microfluidic plates, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids A full line of apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses; flow cytometers, for medical diagnostic uses Online retail store services featuring laboratory apparatus and instruments and their parts, fittings, and accessories therefor and software sold therewith, reagents and chemical preparations, and laboratory consumables; business consulting and advisory services for laboratories, clinics, healthcare providers and related businesses to improve laboratory processes, quality, performance, productivity, efficiency, reduce waste and reduce costs; business consulting services, namely, evaluation of laboratory workflows and processes to improve quality, performance, and efficiency; business efficiency advice for laboratories, clinics, healthcare providers and related businesses Repair and maintenance of laboratory equipment and diagnostic instruments Providing training in the use of laboratory equipment and diagnostic instruments; training for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency; conducting workshops and seminars for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency Scientific research; scientific analysis of data; laboratory analysis in the field of medicine, namely, analysis of chemical markers; consulting services in the field of laboratory operation and automation; consulting services in the field of laboratory testing, diagnostics, and laboratory processes and standards; research in the field of laboratory equipment and instruments; product development for laboratory and diagnostic equipment; technical support services in the nature of troubleshooting of problems with laboratory apparatus and instruments; providing technical support in the nature of technical advice in the operation of laboratory apparatus and instruments; Software as a service (SAAS) services featuring software for uploading, managing, analyzing, sharing, and preserving data related to scientific research and medical diagnostic testing; software as a service (SAAS) services featuring software for automating and optimizing workflow operations, for workflow management for laboratories, and electronic data interchange (EDI); providing temporary use of non-downloadable medical analysis software for use in patients diagnostics; providing temporary use of non-downloadable cloud-based software for assisting hospitals and medical laboratories in clinical, financial reimbursement decisions, inventory management, sample scheduling, and laboratory management and regulatory reporting; software as a service (SAAS) services featuring software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; software as a service (SAAS) services featuring software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; software as a service (SAAS) services featuring software for data analysis for laboratory, scientific, research, and medical use; software as a service (SAAS) services featuring artificial intelligence software for managing and analyzing data from laboratory and diagnostic instruments; software as a service (SAAS) services featuring laboratory middleware software; software as a service (SAAS) services featuring software for clinical decision support Medical information; providing healthcare information; providing medical testing information; analysis and development of medical diagnostic tests; providing medical information to medical professionals in the form of biomedical data; providing personalized healthcare and medical information in the form of biomedical data; medical diagnostic reporting services
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
A full line of chemical preparations and reagents, for scientific and research use; reagents, assays, and chemical preparations all for scientific, research, and laboratory purposes and analysis; chemical preparations, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; reagents for use in genetic research; genomic reagents, for scientific and research use; flow cytometry reagents, for scientific and research use; reagents and chemical preparations used for the identification and characterization of cells, for scientific and research use; reagents for use in particle size analysis and characterization, for scientific and research use; panels of reagents, for scientific and research use; laser excitable dyes, for scientific and research use; fixable viability dyes, for scientific and research use; dyes and stains for the identification and characterization of cells, for scientific and research use; chemical reagents containing magnetic beads for the isolation, purification, and extraction of DNA and RNA, for scientific and research use; nucleic acid isolation and purification kits consisting primarily of reagents and magnetic beads, for scientific and research use; lysing reagents, for scientific and research use; chemiluminescent reagents, for scientific and research use A full line of chemical preparations and reagents, for medical purposes; reagents and chemical preparations, for medical diagnostic purposes; panels of reagents, for medical purposes; medical assays for testing of body fluids; chemicals and reagents for in vitro medical diagnostic use; reagents, assays, and chemical preparations for testing of biological specimens, for medical diagnostic purposes; reagents for use in flow cytometry, for medical purposes; lysing reagents, for medical purposes; biological tissue, namely, animal cells, tissues, and blood, for medical purposes; medical diagnostic reagents and solutions, namely, diluents; antibiotics in test containers, canisters, panels and microtitre plates, for medical use; chemiluminescent reagents, for medical use A full line of analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor and software sold therewith; laboratory apparatus and instruments, for scientific or research purposes and software for use in connection with the apparatus and instruments; downloadable and recorded software for use in operating, monitoring, and controlling laboratory and diagnostic apparatus and instruments and analyzing data generated by the apparatus and instruments; laboratory instruments for the analysis of biological samples and bodily fluids, for scientific and research purposes; laboratory robots; laboratory sample preparation instruments; automated sample handling equipment, for scientific and research use; automated liquid handling instruments, for scientific and research use; bioreactors for laboratory use; automated laboratory equipment for cell culturing; air particle counters; multi-parameter biological cell sorter instruments, for scientific and research use; centrifuges; centrifuge rotors; flow cytometers; total organic carbon analyzers, for scientific and research purposes; instruments for particle sizing, counting, and analysis; microparticle processor apparatus and instruments, for scientific and research purposes; apparatus and instruments for nucleic acid cleanup and purification; cell analyzers; computer hardware and downloadable and recorded computer operating software for use with laboratory and diagnostic instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, instrument operation, sample management, connectivity, data analysis, and data management; downloadable and recorded software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; recorded and downloadable software for use with laboratory instruments, namely, for use in monitoring and controlling the operation of the instrument, setting up experiment protocols, sample management, data collection, data management, and data analysis; recorded and downloadable software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; computer system comprised primarily of computer hardware and computer software used for collecting, managing, interpreting, and analyzing data from laboratory instruments; downloadable and recorded data analysis software for laboratory, scientific, research, and medical use; computer software using artificial intelligence for managing and analyzing data from laboratory and diagnostic instruments; downloadable and recorded laboratory middleware software; downloadable and recorded software for clinical decision support; recorded and downloadable software for sample processing and storage, sample sorting, routing, sample scheduling and sample analysis for use with medical and laboratory diagnostic systems; laboratory consumables for scientific and research use, namely, laboratory centrifuge buckets and adapters, automated lab positioners, laboratory specimen tubes, laboratory specimen bottles, test tube racks for laboratory specimen handling and storage, laboratory specimen tube rack inserts, test tube rack holders, laboratory storage devices in the nature of cap mats, laboratory plate seal rollers and seals therefor, well plates, reagent and solvent reservoirs, pipette tips, probes, laboratory cassettes for specimen processing and storage, cell culture flask adapters, disposable plastic bioreactors for cell culturing, well plates, microfluidic plates, lids for well plates, lids for microfluidic plates, reagent bottles sold empty, reagent holding trays, funnels, droppers, dropper caps and waste bags specially adapted for holding laboratory waste, and rehydrator and inoculator devices for rehydrating and inoculating multiple wells with inoculum liquids A full line of apparatus and instruments for medical diagnostic use and their parts, fittings, and accessories therefor and software sold as a unit therewith; clinical laboratory analyzers; apparatus and instruments for medical diagnostic use; instrument for the analysis of biological samples and bodily fluids, for medical purposes; medical diagnostic analyzers with computer hardware and computer software for use therewith, sold as a unit; instruments for use in automated microbial identification and susceptibility testing, for medical purposes; urine analyzers, for medical purposes; chemistry analyzers, for medical purposes; protein chemistry analyzers, for medical purposes; immunoassay apparatus and instruments, for medical purposes; hematology analyzers, for medical purposes; automated blood banking analyzers; automated sample handling and testing equipment; sample preparation device, for medical diagnostic uses; flow cytometers, for medical diagnostic uses Online retail store services featuring laboratory apparatus and instruments and their parts, fittings, and accessories therefor and software sold therewith, reagents and chemical preparations, and laboratory consumables; business consulting and advisory services for laboratories, clinics, healthcare providers and related businesses to improve laboratory processes, quality, performance, productivity, efficiency, reduce waste and reduce costs; business consulting services, namely, evaluation of laboratory workflows and processes to improve quality, performance, and efficiency; business efficiency advice for laboratories, clinics, healthcare providers and related businesses Repair and maintenance of laboratory equipment and diagnostic instruments Providing training in the use of laboratory equipment and diagnostic instruments; training for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency; conducting workshops and seminars for laboratories, clinics, healthcare providers and related businesses to improve laboratory quality, performance, and efficiency Scientific research; scientific analysis of data; laboratory analysis in the field of medicine, namely, analysis of chemical markers; consulting services in the field of laboratory operation and automation; consulting services in the field of laboratory testing, diagnostics, and laboratory processes and standards; research in the field of laboratory equipment and instruments; product development for laboratory and diagnostic equipment; technical support services in the nature of troubleshooting of problems with laboratory apparatus and instruments; providing technical support in the nature of technical advice in the operation of laboratory apparatus and instruments; Software as a service (SAAS) services featuring software for uploading, managing, analyzing, sharing, and preserving data related to scientific research and medical diagnostic testing; software as a service (SAAS) services featuring software for automating and optimizing workflow operations, for workflow management for laboratories, and electronic data interchange (EDI); providing temporary use of non-downloadable medical analysis software for use in patients diagnostics; providing temporary use of non-downloadable cloud-based software for assisting hospitals and medical laboratories in clinical, financial reimbursement decisions, inventory management, sample scheduling, and laboratory management and regulatory reporting; software as a service (SAAS) services featuring software for technical support and advice, troubleshooting, diagnosis, repair, and maintenance of laboratory equipment and diagnostic instruments; software as a service (SAAS) services featuring software for collecting, managing, storing, analyzing, and reporting biological information, and for managing projects, laboratory workflows, and data, for use for scientific, diagnostic, and research purposes; software as a service (SAAS) services featuring software for data analysis for laboratory, scientific, research, and medical use; software as a service (SAAS) services featuring artificial intelligence software for managing and analyzing data from laboratory and diagnostic instruments; software as a service (SAAS) services featuring laboratory middleware software; software as a service (SAAS) services featuring software for clinical decision support Medical information; providing healthcare information; providing medical testing information; analysis and development of medical diagnostic tests; providing medical information to medical professionals in the form of biomedical data; providing personalized healthcare and medical information in the form of biomedical data; medical diagnostic reporting services
75.
APPARATUS, METHOD AND SYSTEM FOR ASSIGNING PROCESSING STEPS TO A LABORATORY AUTOMATON SYSTEM
A computer-implemented method is provided. The method comprises: accessing, by a first computing device, sample-processing data, wherein the sample-processing data comprise information indicative of a set of procedures to be carried out on a biological sample, wherein each procedure comprises one or more actions; obtaining, by the first computing device, ALS1 state data, wherein the ALS1 state data comprise information indicative of a state of a first automated laboratory system – ALS1; obtaining, by the first computing device, ALS2 operation data, wherein the ALS2 operation data comprise information indicative of an ALS2 set of actions of at least a first procedure, wherein the ALS2 set of actions either has been carried out or is scheduled to be carried out by a second automated laboratory system – ALS2 – on the biological sample; generating, by the first computing device, ALS1 processing data by using the sample-processing data, the ALS1 state data and the ALS2 operation data, wherein the ALS1 processing data comprise information indicative of an ALS1 set of actions of at least a second procedure of the sets of procedures; and initiating, by the first computing device, the generation of an ALS1 route plan for the first automated laboratory system, the ALS1 route plan being based on the ALS1 processing data.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
This disclosure describes methods of and systems for screening for sepsis or septic shock in a patient and methods of ruling out sepsis or septic shock in a patient using white blood cell count (WBC), a monocyte cell population parameter, or neutrophil-to-lymphocyte ratio (NLR), or a combination thereof, in the blood sample from the patient
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
A sampling system that includes a traverse, a sample aspiration module body, and a mechanical system. The sample aspiration module body is configured to travel along the traverse. The mechanical system is configured to move the traverse from a first position to a second position, wherein both the first position and the second position lie in the same plane.
A visual analysis system may be automatically focused (or the focus of such a. system may be automatically corrected) by subjecting one or more images captured by such a system to a multi- layer analysis. In such an analysis, a cell boundary may be identified in an input image based on the lightness value of the pixels of the input image. Based on the identified cell boundary, a predicted nominal focus value is determined which can provide a focusing distance (e.g., a distance between the focal plane of a camera used when an image was captured and the actual focal plane for an in-focus image). This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).
A method of installing a module associated with a life sciences laboratory workstation includes positioning at least a portion of at least one rail to extend outside the laboratory workstation; disposing the module on the at least one rail at a first position that is at least partially outside of the laboratory workstation; moving the module from the first position to a second position within the laboratory workstation via the at least one rail positioned within the laboratory workstation; transferring the module from the at least one rail to an actuator platform located within the laboratory workstation; and causing the actuator platform to position the module at a predetermined position within the laboratory workstation.
B01L 9/02 - Laboratory benches or tables; Fittings therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
The present disclosure provides a method (400) of detecting bubbles (12) in a sample liquid (10) disposed in a container (102). The method (400) comprises capturing a first image (210) of the container (102) at a first time instance; capturing a second image (212) of the container (102) at a second time instance after the first time instance; comparing the first image (210) with the second image (212) to determine a pattern matching score (S1); and determining a presence of bubbles (12) in the sample liquid (10) if the pattern matching score (S1) crosses a predetermined threshold score (S2).
A biological analysis system includes a flow generator, a flowcell, a first flow path, and a second flow path. The flow generator is configured to provide a sheath fluid. The flowcell is configured to receive a biological sample. The first flow path is in fluid communication with the flow generator and configured to receive a first portion of the sheath fluid from the flow generator. The first flow path is configured to convey the biological sample using the first portion to the flowcell at a first flow rate. The second flow path is in fluid communication with the flow generator and configured to receive a second portion of the sheath fluid from the flow generator. The second flow path is configured to convey the second portion to the flowcell at a second flow rate. The second flow rate is different than the first flow rate.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
The present disclosure provides a computing device (100) for classification of an aspirating/dispensing operation in an automated analyzer (50). The computing device (100) comprises a memory (22) storing a neural network model (24). The neural network model 24 sequentially comprises a plurality of convolution blocks (202-1, 202-2...202-N). The computing device (100) further comprises a processor (20) communicably coupled to the memory (22) and at least one measurement sensor (106) associated with a pipetting probe (104) of a pipetting device (102). The processor (20) is capable of executing the neural network model (24). The processor (20) is further capable of executing instructions (26) to classify the aspirating/dispensing operation into at least one correct class or at least one incorrect class.
In a method for controlling a centrifuge (100) comprising a rotor (106) and a drive component (104) for the rotor (106), an acoustic signal (AS) is received, at a computing device (102), via a sound transducer (108) located proximate to the rotor (106) of the centrifuge (100). The acoustic signal (AS) is pre-processed, by the computing device (102), by emphasizing at least one predetermined signal feature of the acoustic signal (AS), the signal feature indicating an abnormal operation of the centrifuge (100). An abnormal operation of the centrifuge (100) is detected, by the computing device (102), by processing the emphasized signal feature. An alarm signal and/or a termination signal (212) is generated, by the computing device (102), if an abnormal operation of the centrifuge (100) is detected.
A tube from a plurality of tubes from a tube rack configured to removably hold the plurality of tubes are removed from a tube rack. A weight of the tube which has been removed from the tube rack is determined. A balancing parameter of the tube is determined by a computing device. An estimated balancing parameter of each of a plurality of remaining tubes from the plurality of tubes in the tube rack is determined. A corresponding rotor position from a plurality of rotor positions within the rotor for the tube is determined by the computing device based at least on the balancing parameter of the tube, the balancing parameters of previously placed tubes from the plurality of tubes placed within the rotor and the estimated balancing parameter of each of the plurality of remaining tubes. The transport unit places the tube in the corresponding rotor position within the rotor.
A biological analysis system includes a probe. The probe is configured to dispense a biological sample into a first chamber. The system also includes a pump. The pump is configured to convey a first delivery of diluent to the first chamber for mixing with the biological sample to produce a sample mixture, aspirate a portion of the sample mixture from the first chamber, and convey the portion of the sample mixture to a second chamber. A method of analyzing a biological sample includes conveying a diluent to a first chamber via a first pump, dispensing a blood sample into the first chamber via a probe to produce a sample mixture, and conveying a portion of the sample mixture from the first chamber to a second chamber via the first pump.
Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
C08G 61/10 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
C09B 69/10 - Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
88.
Analog light measuring and photon counting in chemiluminescence measurements comprising a luminometer controller to compare digitized photon count to a discreet-analog crossover value
b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).
A sample analysis system analyzes a sample. A panel design generates a sample preparation specification. A preparation instrument prepares a sample using the sample preparation specification to generate a prepared sample. A sample analyzer analyzes the prepared sample. A validator validates an operation of the sample analysis system. A sample analysis system has a transfer station that controls the movement of a probe with respect to a reaction plate. A probe wash module is also disclosed.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
91.
MESH NETWORK SYSTEM OF ENVIRONMENTAL MONITORING DEVICES
Monitoring devices, such as air particle counters, having mesh network capabilities are described for implementation in environmental monitoring within a facility. The air particle counters run samples at various facility locations based on a standard operating procedure (SOP). Each air particle counter can opportunistically connect with one or more other air particle counters using mesh networking. Data from samples run by and any new or updated SOP received at the air particle counters can be distributed via database replication across the other air particle counters using the mesh networking such that each air particle counter has a copy of the sample data and a current SOP within its database. A dashboard user interface displaying a hierarchical representation of the SOP and an associated compliance status with the SOP can be generated and updated based on data received from the air particle counters to facilitate SOP management.
A system for acquiring the image data of refrigerated materials is disclosed. The system includes a material management unit with an imaging system. The material management unit further includes a refrigerated chamber in which material vials are stored. The imaging system includes a window positioned on the side of the material management unit that separates an interior space of the refrigerated chamber from an exterior space of the material management unit. The imaging system further includes a camera positioned in the exterior space that captures image data through the window. The window is heated along its sides by a heating element, which functions to prevent condensation from forming on the surface of the window.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
A system for measuring a biological sample includes a sample collection vessel and a removable analysis cartridge that is removable from the sample collection vessel.
An aspect of the present invention relates to an archiving method for archiving in a storage, in particular in a cold storage, at least one sample tube containing a biological sample using at least one tube rack, the method comprising the following steps: receiving, by a computing system, a request for archiving the at least one sample tube, placing the at least one sample tube in at least one receptacle of the at least one tube rack to receive the at least one sample tube, recording and/or updating, in a memory unit of the computing system, sample-tube-storage-data including sample tube data and/or tube rack data and/or storage data, storing the at least one tube rack in the storage. Further aspects relate to a retrieving method and a tube rack.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Diagnostic reagents for the determination of minimum inhibitory concentrations, for medical or clinical laboratory use. Medical apparatus, namely laboratory test indicators, for determining minimum inhibitory concentrations, for medical or clinical laboratory use.
96.
Enhancing flow cytometry discrimination with geometric transformation
In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Diagnostic reagents for use in the determination of minimal inhibitory concentrations for use in medical and clinical laboratories; diagnostic reagents in the form of test panels for use in the determination of minimal inhibitory concentrations for use in medical and clinical laboratories.
98.
Method of Detecting Sepsis Using Primary and Secondary Hematology Parameters
Systems and methods of assessing a probability that an individual will develop sepsis are provided. The systems and methods can include obtaining a set of parameters associated with the individual including white blood cell count (WBC) and monocyte distribution width (MDW) value, and determining whether the set of parameters provides an elevated risk status by comparing at least the WBC and the MDW value with respective predetermined criteria. In the event that the set of parameters is determined to provide the elevated risk status, the systems and methods can further include obtaining a secondary parameter associated with the individual; and providing the probability that the individual will develop sepsis.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/021 - Measuring pressure in heart or blood vessels
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
The disclosure relates to hematological parameters of viral infection. More specifically, the present disclosure relates to automated volume biomarkers lymph index and monocyte distribution width (MDW) for early detection of Coronavirus infection. The invention also relates to a method, device and computer executable program for early diagnosis of SARS-CoV-2 infection using volume biomarker lymph index and monocyte distribution width (MDW). According to some technical solutions of the present invention, the automated volumetric parameter lymph index and MDW can be used as viral biomarkers to help healthcare workers in the out-patient department or fever clinic to rapidly identify those who might be infected with SARS-CoV-2 and to provide valuable information for triage decision making.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
100.
DETECTION OF MEDICAL CONDITION, SEVERITY, RISK, AND ACUITY USING PARAMETERS
Systems and methods of assessing a probability that an individual will develop sepsis are provided. The systems and methods can include obtaining a set of parameters associated with the individual including white blood cell count (WBC) and monocyte distribution width (MDW) value, and determining whether the set of parameters provides an elevated risk status by comparing at least the WBC and the MDW value with respective predetermined criteria. In the event that the set of parameters is determined to provide the elevated risk status, the systems and methods can further include obtaining a secondary parameter associated with the individual; and providing the probability that the individual will develop sepsis.
G01N 33/487 - Physical analysis of biological material of liquid biological material
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
