The invention relates to methods of treating diseases comprising administering to a subject a composition comprising the recombinant adeno-associated virus (rAAV). The rAAV is produced by a method comprising: obtaining a template DNA sequence containing a [ITR-cargo-ITR] DNA sequence motif; designing a PCR primer pair such that the 3′ terminus of both the forward and reverse PCR primers overlap only about the last 2-8 bases of the A/A′ ITR sequences and the 5′ terminus of both the forward and reverse PCR primers extend into about 20-35 bases of the flanking sequences; performing PCR with cycling parameters comprising a combined annealing/extension step at a temperature greater than 70° C., thereby producing a plurality of amplicon polynucleotides containing the desired [ITR-cargo-ITR] DNA sequence motif; transfecting the amplicon polynucleotides containing the desired [ITR-cargo-ITR] DNA sequence motif into a packaging cell line; and purifying the lysed cells to collect a quantity of rAAV.
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
2.
ENGINEERED LYMPHOCYTE COMPOSITIONS, METHODS AND SYSTEMS
The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
3.
Nucleic Acid Coated Micron and Submicron Particles for Authentication
A composition comprising micron or submicron particles covered by a monolayer of nucleic acid wherein the nucleic acid may be recovered from the submicron particles is claimed. Methods of attaching a nucleic acid to an object for authentication and methods of authenticating an object are also claimed.
The present invention relates to systems and methods to produce recombinant adeno-associated virus (rAAV) utilizing one or more DNA constructs manufactured via polymerase chain reaction (PCR).
The present invention relates generally to a system and method of tracking leather raw materials through the supply chain to create a source verifiable finished leather product through one or more applications of DNA taggants during the leather manufacturing process and the subsequent authentication of said DNA taggants.
B05D 7/12 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à du cuir
B05D 5/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
The present invention relates generally to a system and method of tracking leather raw materials through the supply chain to create a source verifiable finished leather product through one or more applications of DNA taggants during the leather manufacturing process and the subsequent authentication of said DNA taggants.
C14C 1/00 - Traitement des peaux ou cuirs avec des produits chimiques, des enzymes ou des micro-organismes avant le tannage
C14C 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes
C14B 17/00 - TRAITEMENTS OU TRANSFORMATIONS MÉCANIQUES DES PEAUX OU DU CUIR EN GÉNÉRAL; TONDEUSES POUR FOURRURES; MACHINES À REFENDRE LES BOYAUX - Parties constitutives des appareils ou machines pour la fabrication ou le traitement des peaux, du cuir ou des fourrures
7.
ENGINEERED LYMPHOCYTE COMPOSITIONS, METHODS AND SYSTEMS
The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
The present inventions provides systems and methods to manufacture genetically modified lymphocyte cells via the use of linear DNA expression amplicons, and uses of such genetically modified lymphocyte cells to treat disease. The present invention also provides for the composition of genetically modified lymphocyte cells.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C12N 15/00 - Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p.ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
H04W 8/00 - Gestion de données relatives au réseau
10.
SYSTEMS AND METHODS FOR TRACKING THE ORIGIN OF CANNABIS PRODUCTS AND CANNABIS DERIVATIVE PRODUCTS
The invention provides for a system to track the origin of cannabis products and cannabis derivative products without the need for packaging or labeling through the use of nucleic acid tags. The invention further provides for a method of tracking the origin of cannabis products and cannabis derivative products via the application of nucleic acid tags to cannabis plants.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
11.
SYSTEMS AND METHODS FOR TRACKING THE ORIGIN OF CANNABIS PRODUCTS AND CANNABIS DERIVATIVE PRODUCTS
The invention provides for a system to track the origin of cannabis products and cannabis derivative products without the need for packaging or labeling through the use of nucleic acid tags. The invention further provides for a method of tracking the origin of cannabis products and cannabis derivative products via the application of nucleic acid tags to cannabis plants.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
12.
Encrypted optical markers for security applications
Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The encrypted marker may include a DNA taggant.
G07D 7/14 - Vérification spécialement adaptée à la détermination de l’identité ou de l’authenticité de papiers de valeur ou pour discriminer ceux qui sont inacceptables, p.ex. qui ne correspondent pas à une monnaie à l'aide de moyens chimiques
C40B 20/04 - Identification des éléments d'une bibliothèque au moyen d'une étiquette, d'un marqueur ou d'un autre identificateur lisible ou détectable, p.ex. procédés de décodage
B42D 25/00 - Cartes ou structures de type feuille portant des informations caractérisées par leurs éléments d’identification ou de sécurité; Leur fabrication
C09B 11/22 - Dérivés aminés de triarylméthanes contenant des groupes —OH liés à un noyau aryle
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 69/10 - Colorants polymères; Produits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C09B 23/16 - Colorants méthiniques ou polyméthiniques, p.ex. du type cyanine la chaîne polyméthinique contenant des hétéro-atomes
C09B 57/10 - Complexes métalliques de composés organiques qui ne sont pas des colorants sous la forme non complexée
G07D 7/202 - Vérification de motifs des papiers en utilisant la mise en correspondance de motifs
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes
13.
NUCLEIC ACID COATED SUBMICRON PARTICLES FOR AUTHENTICATION
A composition comprising submicron particles covered by a monolayer of nucleic acid wherein the nucleic acid may be recovered from the submicron particles is claimed. Methods of attaching a nucleic acid to an object for authentication and methods of authenticating an object are also claimed.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A composition comprising submicron particles covered by a monolayer of nucleic acid wherein the nucleic acid may be recovered from the submicron particles is claimed. Methods of attaching a nucleic acid to an object for authentication and methods of authenticating an object are also claimed.
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
The invention pertains to a traceable fertilizer product marked with a nucleic acid marker. The invention further provides for a method of marking a fertilizer product with a nucleic acid marker. In addition, the invention teaches a method of using a nucleic acid marked fertilizer product to identify and validate the origin or authenticity of said fertilizer product and to perform quantitative analysis on the fertilizer product to determine if said fertilizer product has been adulterated, diluted and/or counterfeited.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A system associated with authentication of an object related to a multi-mode marker using a processing device. The processing device performs operations that include detecting a signal associated with a multi-mode marker related with the object; assigning a digital code based on the detected signal associated with the multi-mode marker; and identifying the object based on the digital code related to authentication of the object. A corresponding method and computer-readable device are also disclosed.
G06K 5/00 - Méthodes ou dispositions pour vérifier l'exactitude du marquage sur un support d'enregistrement; Dispositifs de localisation de colonne
G06F 17/30 - Recherche documentaire; Structures de bases de données à cet effet
G06K 7/00 - Méthodes ou dispositions pour la lecture de supports d'enregistrement
G06K 19/06 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p.ex. forme, nature, code
G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p.ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré
Methods for marking cellulosic products, including cellulosic fibers such as lyocell and cellulosic films, including methods for marking such products with a detectable nucleic acid marker to identify and validate the origin or authenticity of the products or items manufactured using such products. Detectably-marked cellulosic products marked with nucleic acid markers for authentication, validation and tracking are also provided.
B05D 1/02 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation
B05D 5/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
B41M 5/00 - Procédés de reproduction ou méthodes de reproduction ou de marquage; Matériaux en feuilles utilisés à cet effet
C09B 62/00 - Colorants réactifs, c. à d. colorants formant des liaisons de covalence avec les substrats ou se polymérisant sur eux-mêmes
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
Methods for marking cellulosic products, including cellulosic fibers such as lyocell and cellulosic films, including methods for marking such products with a detectable nucleic acid marker to identify and validate the origin or authenticity of the products or items manufactured using such products. Detectably-marked cellulosic products marked with nucleic acid markers for authentication, validation and tracking are also provided.
D21H 21/44 - Eléments de sécurité latents, c. à d. pouvant être détectés ou devenant apparents uniquement par utilisation de méthodes ou de dispositifs particuliers de vérification ou d'altération
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes
A method and system of identifying articles in commerce including tagging a raw material during said raw material's manufacturing process with a unique molecular marker in a home country in which the raw material was produced. The marker identifies home country information. The tagged raw material is transported from the home country to a foreign country. The tagged raw material is processed in the foreign country to generate a processed product. The processed product is transported to the home country. The processed product is analyzing to determine the presence of the marker in the processed product. A determination is made whether the raw material originated in the home country in response to the detection of the marker.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
D04H 1/587 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par application, incorporation ou activation de liages chimiques ou thermoplastiques, p.ex. adhésifs caractérisé par les agents de liage utilisés
D04H 1/64 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par application, incorporation ou activation de liages chimiques ou thermoplastiques, p.ex. adhésifs l'agent de liage étant appliqué à l'état humide, p.ex. agents chimiques en dispersion ou solution
20.
DNA marking of previously undistinguished items for traceability
The invention provides a method of marking an item with naturally-derived or synthetic non-natural polymeric marker molecules, such as a DNA or Peptide marker in conjunction with optional visible or rapid scan reporters for authenticating or tracking, in which the method includes providing an item for marking, and applying a medium including a DNA marker to the item. The invention further provides methods for stably binding and immobilizing activated deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. Also provided are methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. The invention also provides a method of marking an item with a DNA marker for authenticating or tracking, in which the method includes providing a medium including a DNA marker, and molding the medium including the DNA marker to provide all or part of the item. The DNA marker encodes information unique to the item and/or the model of the item as desired.
G07D 7/14 - Vérification spécialement adaptée à la détermination de l’identité ou de l’authenticité de papiers de valeur ou pour discriminer ceux qui sont inacceptables, p.ex. qui ne correspondent pas à une monnaie à l'aide de moyens chimiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
21.
Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
The invention provides methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. Methods for authentication of a taggant marked object are also provided.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
Methods for genetic analysis of commodities and raw materials containing DNA, including components and ingredients of dietary supplements are disclosed. The method include extracting DNA from at least one component of a commodity, and the DNA is genetically analyzed by any process used in the art, such as next-generation sequencing methods, to identify at least one DNA sequence. The DNA sequence or a plurality of DNA sequences may then be used authenticate the commodity, or alternatively, to identify and or quantify one or more plant or animal species of the commodity and its components of a commodity or raw material. The one or more identified plant or animal species identified by the methods of the invention as components of a commodity or raw material may be used to verify security of supply chain by tracing a commodity throughout the chain and to compare the analyzed goods to specifications as purchased for compliance, standardization, expected monetary value, and/or accuracy.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
A01H 5/00 - Angiospermes, c. à d. plantes à fleurs, caractérisées par leurs parties végétales; Angiospermes caractérisées autrement que par leur taxonomie botanique
23.
HYDROPHOBIC NUCLEIC ACID SALTS AS SECURITY MARKERS
The invention provides a method of marking a hydrophobic medium with a nucleic acid marker, the method includes: providing a trialkylammonium salt of the nucleic acid marker, a tetraalkylphosphonium salt of the nucleic acid marker or a tetraarylphosphonium salt of the nucleic acid marker; and incorporating the trialkylammonium salt of the nucleic acid marker, the tetraalkylphosphonium salt of the nucleic acid marker or the tetraarylphosphonium salt of the nucleic acid marker into the hydrophobic medium. The hydrophobic medium can be authenticated after shipping or recovery from the stream of commerce by detecting the nucleic acid marker in a sample of the hydrophobic medium.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C10L 1/238 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
C10L 1/10 - Combustibles carbonés liquides contenant des additifs
Provided is a method of authenticating an active pharmaceutical ingredient (API). The method includes providing an API or an API component and adding a nucleic acid marker having a nucleic acid marker sequence to produce a marked API or a marked API component. At least a portion of the marked API or marked API component is incorporated into a pharmaceutical product. A sample of the pharmaceutical product including the marked API or marked API component is obtained. The sample is subjected to an amplification reaction to produce one or more amplification products that are characteristic of the nucleic acid marker. The presence of the nucleic acid marker is detected in the sample and the authenticity of the API is thereby determined according to whether the pharmaceutical product includes marked API or the marked API component.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
25.
QUANTITATIVE GENETIC ANALYSIS OF ARTICLES INCLUDING GOSSYPIUM BARBADENSE AND GOSSYPIUM HIRSUTUM COTTON
Exemplary embodiments of the present invention provide a method for assessing a proportion of one or more cotton species in an article comprising cotton. The method includes providing a sample including cotton fibers from the article comprising cotton. Cotton DNA is extracted from the cotton fibers to provide extracted cotton DNA. The extracted cotton DNA is analyzed to identify a presence of one or more cotton species included in the article comprising cotton. Proportions of the one or more cotton species included in the article comprising cotton are assessed.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A multi-mode reader instrument capable of detecting and determining digital data from a signal from one or more markers, indicia or taggants on an object, the markers, indicia or taggants such as a bar code, a QR code, an RFID, an optical compound, a fluorescent compound, a phosphorescent compound, a DNA taggant, an upconverting phosphor (UCP), a chemical dye, a digitized image, a radioactive compound, an olfactory compound or a thermal attribute of the object is provided. Also, provided is a method and a system for identifying an object, the system includes: a multi-mode reader instrument for detecting data from a signal from one or more markers, indicia or taggants on an object and assignment of digital code for the marker and a database for securing and retrieving information relevant to the item.
G06K 5/00 - Méthodes ou dispositions pour vérifier l'exactitude du marquage sur un support d'enregistrement; Dispositifs de localisation de colonne
G06F 17/30 - Recherche documentaire; Structures de bases de données à cet effet
G06K 7/00 - Méthodes ou dispositions pour la lecture de supports d'enregistrement
G06K 19/06 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p.ex. forme, nature, code
G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p.ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré
A method of marking fibers, wherein the method includes providing a plurality of fibers; depositing a marker onto at least a portion of the fibers, the depositing being performed with a delivery mechanism comprising one or more outlets; and thereby marking the fibers. Also provided is a device for marking fibers, including a transport system adapted to transport fibers in a direction of a marker delivery apparatus positioned along the transport system; the delivery apparatus includes one or more outlets, adapted to deposit a solution of the marker through the outlets onto at least a portion of the fibers; and thereby marking the fibers. Authentication of a fibrous material using the marking method of the invention followed obtaining a sample of the marked fibers and assaying the sample for the presence of the nucleic acid marker; and thereby determining whether the fibrous material is authentic or counterfeit.
A method of marking fibers, wherein the method includes providing a plurality of fibers; depositing a marker onto at least a portion of the fibers, the depositing being performed with a delivery mechanism comprising one or more outlets; and thereby marking the fibers. Also provided is a device for marking fibers, including a transport system adapted to transport fibers in a direction of a marker delivery apparatus positioned along the transport system; the delivery apparatus includes one or more outlets, adapted to deposit a solution of the marker through the outlets onto at least a portion of the fibers; and thereby marking the fibers. Authentication of a fibrous material using the marking method of the invention followed obtaining a sample of the marked fibers and assaying the sample for the presence of the nucleic acid marker; and thereby determining whether the fibrous material is authentic or counterfeit.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
D06M 15/01 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés macromoléculaires; Un tel traitement combiné avec un traitement mécanique avec des composés macromoléculaires naturels ou leurs dérivés
D06M 16/00 - Traitement biochimique des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, p.ex. enzymatique
D01G 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
D01B 9/00 - Autres traitements mécaniques des matières naturelles fibreuses ou filamenteuses, pour obtenir des fibres ou des filaments
D06H 1/00 - Marquage des matériaux textiles; Marquage combiné à la mesure ou à la visite
The invention provides a method for in-field detection of a distinctive marker. The method includes providing a sample from an article of interest and analyzing the sample to detect the presence of the distinctive marker. The analysis is performed using an in-field detection instrument. The in-field detection instrument includes a microsystem configured to perform sample in-answer out analysis and detect the presence of the distinctive marker in the sample.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A method of encrypting information includes converting an information sequence represented as a strings of bits into a curvilinear coding system, where each element of the curvilinear coding system corresponds to a sub-sequence of successive same-valued bits, converting said curvilinear coding system into a at least one closed curve, and embedding said at least one closed curve in a 2-dimensional pattern. A method for decrypting information includes extracting at least one closed curve from a digitized 2-dimensional pattern, and converting the at least one closed curve into an information sequence represented as a string of bits.
G06T 9/20 - Codage des contours, p.ex. utilisant la détection des contours
G09C 5/00 - Appareils ou méthodes de chiffrement ou de déchiffrement non prévus dans les autres groupes de la présente sous-classe, p.ex. comportant la dissimulation ou la déformation de données graphiques telles que dessins, messages écrits ou imprimés
A method of encrypting information includes converting an information sequence represented as a strings of bits into a curvilinear coding system, where each element of the curvilinear coding system corresponds to a sub-sequence of successive same-valued bits, converting said curvilinear coding system into a at least one closed curve, and embedding said at least one closed curve in a 2-dimensional pattern. A method for decrypting information includes extracting at least one closed curve from a digitized 2-dimensional pattern, and converting the at least one closed curve into an information sequence represented as a string of bits.
G06F 21/16 - Traçabilité de programme ou de contenu, p.ex. par filigranage
G09C 5/00 - Appareils ou méthodes de chiffrement ou de déchiffrement non prévus dans les autres groupes de la présente sous-classe, p.ex. comportant la dissimulation ou la déformation de données graphiques telles que dessins, messages écrits ou imprimés
G06T 1/00 - Traitement de données d'image, d'application générale
H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
32.
Security system and method of marking an inventory item and/or person in the vicinity
A method of marking an inventory item includes providing an activatable smoke generator and a reservoir for holding a smoke fluid and adapted to provide a flow of smoke fluid to the generator. The reservoir contains a smoke fluid including a carrier nucleic acid having a uniquely identifiable sequence, and upon activation of the smoke generator, marker smoke is generated and targeted to flow over the inventory item. The method further includes activating the smoke generator to produce the marker smoke including the carrier nucleic acid so as to cause the marker smoke to flow over the inventory item and thereby to detectably mark the inventory item with carrier nucleic acid. The invention provides methods for stably binding and immobilizing deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. The alkaline conditions are produced by mixing the deoxyribonucleic acid with an alkaline solution having a pH of about 9.0 or higher, and contacting the deoxyribonucleic acid to the substrate. The immobilized DNA can be used as a taggant and can be used in combination with other detectable taggants, such as optical reporters.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G08B 15/02 - Identification, mise en alarme ou mise hors d'état de nuire des cambrioleurs, des voleurs ou autres intrus, p.ex. en employant des explosifs avec de la fumée, du gaz, ou de la poudre, ou un liquide coloré ou parfumé
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes
B05D 1/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces
A method of encrypting information includes converting an information sequence represented as a strings of bits into a curvilinear coding system, where each element of the curvilinear coding system corresponds to a sub-sequence of successive same-valued bits, converting said curvilinear coding system into a at least one closed curve, and embedding said at least one closed curve in a 2-dimensional pattern. A method for decrypting information includes extracting at least one closed curve from a digitized 2-dimensional pattern, and converting the at least one closed curve into an information sequence represented as a string of bits.
G06T 9/20 - Codage des contours, p.ex. utilisant la détection des contours
G09C 5/00 - Appareils ou méthodes de chiffrement ou de déchiffrement non prévus dans les autres groupes de la présente sous-classe, p.ex. comportant la dissimulation ou la déformation de données graphiques telles que dessins, messages écrits ou imprimés
34.
ENCRYPTED OPTICAL MARKERS FOR SECURITY APPLICATIONS
Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The marker can be revealed by exposure of the encrypted marker or a sample thereof to the developer in any suitable form, such as a solution, a slurry, a swab, a solid (such as in granular form), or a gas or a vapor that includes a developer.
Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The marker can be revealed by exposure of the encrypted marker or a sample thereof to the developer in any suitable form, such as a solution, a slurry, a swab, a solid (such as in granular form), or a gas or a vapor that includes a developer.
B29C 65/48 - Assemblage d'éléments préformés; Appareils à cet effet en utilisant des adhésifs
G07D 7/14 - Vérification spécialement adaptée à la détermination de l’identité ou de l’authenticité de papiers de valeur ou pour discriminer ceux qui sont inacceptables, p.ex. qui ne correspondent pas à une monnaie à l'aide de moyens chimiques
36.
ENCRYPED OPTICAL MARKERS FOR SECURITY APPLICATIONS
Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The marker can be revealed by exposure of the encrypted marker or a sample thereof to the developer in any suitable form, such as a solution, a slurry, a swab, a solid (such as in granular form), or a gas or a vapor that includes a developer.
Methods for distinguishing between cotton cultivars of a specific species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the cultivar of a particular cotton species utilized in the textile or cotton material of interest.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
38.
ELECTRON BEAM PRE-TREATMENT OF INORGANIC AND POLYMER SURFACES FOR BONDING OF DETECTABLE MARKER MOLECULES
A method of binding a detectable marker to a surface comprising the steps of exposing the surface to an electron beam to produce an electron beam-treated surface; applying a detectable marker to the electron beam-treated surface; and thereby producing a surface-bound detectable marker on the treated surface. The detectable marker can be any suitable marker such as an optical marker, a dye, a fluorophore, a biomolecule, a metal, or a rare earth element. Also provided is a composition including a detectable marker immobilized on a surface pre-treated with an electron beam.
C08F 2/46 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire
B05D 1/04 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation comportant l'emploi d'un champ électrostatique
B05D 1/06 - Application de matériaux en particules
A multi-mode reader instrument capable of detecting and determining digital data from a signal from one or more markers, indicia or taggants on an object, the markers, indicia or taggants such as a bar code, a QR code, an RFID, an optical compound, a fluorescent compound, a phosphorescent compound, a DNA taggant, an upconverting phosphor (UCP), a chemical dye, a digitized image, a radioactive compound, an olfactory compound or a thermal attribute of the object is provided. Also, provided is a method and a system for identifying an object, the system includes: a multi-mode reader instrument for detecting data from a signal from one or more markers, indicia or taggants on an object and assignment of digital code for the marker and a database for securing and retrieving information relevant to the item.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
Provided are a method and device for marking an article for security, tracking or authentication. The method includes depositing a solution comprising a nucleic acid marker onto at least a portion of the article. The nucleic acid marker may be activated, for example, by adding a functional group to the nucleic acid marker. The activation of the nucleic acid marker may be performed by exposure to alkaline conditions. The method is well suited for marking fibers and textiles, as well as many other items.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
Methods for distinguishing between cotton species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the species of cotton utilized in the textile or cotton material of interest.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
The invention provides methods for stably binding and immobilizing deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. The alkaline conditions are produced by mixing the deoxyribonucleic acid with an alkaline solution having a pH of about 9.0 or higher, and contacting the deoxyribonucleic acid to the substrate. The immobilized DNA can be used as a taggant and can be used in combination with other detectable taggants, such as optical reporters. Methods for authentication of a DNA marked object are also provided.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
43.
Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
The invention provides methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. Methods for authentication of a taggant marked object are also provided.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A verifiably identifiable object that includes a primary taggant encoding a readable encrypted first identifier of the object encrypted by a first method and a secondary taggant encoding a readable encrypted second identifier of the object optionally encrypted by a second method. The primary taggant can be a physical identification taggant, such as DNA including an authentication sequence, and the secondary taggant can be a digital identification taggant. The digital identification taggant encodes information validating the physical identification taggant, such as by referencing information embodied in the physical taggant, e.g. the defined sequence within the DNA. Also included is a method and system for identification and/or authentication of an object that includes a primary taggant encoding a readable encrypted first identifier of the object encrypted by a first method and a secondary taggant encoding a readable encrypted second identifier of the object encrypted by a second method.
G06K 19/10 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p.ex. forme, nature, code utilisant des marquages de différentes sortes sur le même support d'enregistrement, p.ex. un marquage étant lu optiquement et l'autre par des moyens magnétiques au moins une sorte de marquage étant utilisée pour l'authentification, p.ex. de cartes de crédit ou de cartes d'identité
The invention provides a composition including DNA bonded to a plasma-treated surface, the plasma can be any suitable plasma, such as an argon plasma, a compressed air plasma, a flame-based plasma or a vacuum plasma. Surfaces treatable by the methods of the invention include ceramic, metal, fabric and organic polymer surfaces. The DNA can be any DNA, such as a marker DNA, which can be linear or circular, single-stranded or double stranded and from about 25 bases to about 10,000 bases in length. Also provided is a method of binding DNA to a surface, including the steps of exposing the surface to a plasma to produce a plasma-treated surface; and applying DNA to the plasma-treated surface to produce surface bound DNA on the treated surface. A system for binding DNA to a surface is also disclosed, the system includes a plasma generator adapted to treating a surface with a plasma to produce a plasma-treated surface; and an applicator containing DNA adapted to applying DNA to the plasma-treated surface to produce surface bound DNA on the plasma-treated surface.
Methods for distinguishing between cotton cultivars of a specific species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the cultivar of a particular cotton species utilized in the textile or cotton material of interest.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
A material for indelibly and uniquely marking an article for identification purposes includes a mixture including between about 1% and 10% by weight fluorescent identifier, DNA, and the remainder including predominantly a solvent.
C09K 3/30 - Substances non couvertes ailleurs pour aérosols
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G08B 15/02 - Identification, mise en alarme ou mise hors d'état de nuire des cambrioleurs, des voleurs ou autres intrus, p.ex. en employant des explosifs avec de la fumée, du gaz, ou de la poudre, ou un liquide coloré ou parfumé
This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
Anti-counterfeiting system comprised of DNA coating, namely, marking ink and coatings containing DNA for the encryption and authentification of objects
