A delivery apparatus configured to deliver a prosthetic valve can include a handle, a first shaft extending distally from the handle, a second shaft extending through a lumen of the first shaft, a nose cone mounted on a distal end portion of the second shaft, a balloon mounted along the distal end portion of the second shaft, and a first pull wire extending longitudinally along the second shaft. A distal end of the first pull wire is fixed relative to the second shaft at a location that is distal to a distal end of the balloon. Tension in the first pull wire can be adjusted to adjust a curvature of the distal end portion of the second shaft and the nose cone.
An implantable prosthetic device can include a radially expandable and compressible annular frame comprising an inflow end portion and an outflow end portion, and a plurality of leaflets arranged within the frame. Each leaflet can include one or more commissure tabs. The commissure tabs of two adjacent leaflets coupled to a commissure attachment member to form a commissure. The commissure can be secured to the frame via first and second sutures, each suture extending through a respective commissure tab, through the commissure attachment member, crossing over the other suture and being secured to the frame. The commissure can define a bending axis disposed radially inwardly of the frame such that a main body of each leaflet is prevented from contacting the frame when the valvular structure is in an open configuration.
Devices, systems, and/or methods can provide compliance characteristics to fluid vessels. For example, an implant device can include an anchoring structure to anchor the implant device to a blood vessel, heart valve, or other anatomy. The anchoring structure can be coupled to an elastic tube that is configured to expand. The elastic tube can include a prosthetic valve to permit fluid to flow through the implant device.
Devices, systems, and/or methods discussed herein relate to medical device packaging that includes various features for packaging a medical device and/or preparing the medical device for use in a procedure. For example, packaging can include features to retain a medical device during distribution, such as foldable ends that are configured to cover the medical device. Further, the packaging can include features that are configurable to elevate one end of packaging to assist in preparing the medical device for a procedure, such as to flush the medical device in an elevated state. Moreover, the packaging can include features to hold and/or dispose of a fluid in an efficient manner.
A61B 50/20 - Récipients, étuis, mobilier ou supports spécialement adaptés aux appareils ou aux instruments chirurgicaux ou de diagnostic, p.ex. étuis stériles Équipements de support spécialement adaptés aux appareils ou aux instruments chirurgicaux ou de diagnostic
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A compliance-restoration system comprises an implant configured to be inflated with a fluid, the implant having a proximal portion and a distal portion, the proximal portion and the distal portion configured to expand in width in response to receiving fluid, wherein the distal portion is configured to inflate with the fluid in response to deflation of the proximal portion.
A61F 2/915 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles fabriquée à partir de feuilles perforées ou de tubes perforés, p.ex. perforés par découpe au laser ou gravés avec des bandes présentant une structure en méandre, des bandes adjacentes étant reliées l’une à l’autre
A cardiac implant comprises a frame forming an inner lumen and configured for delivery into a blood vessel and a covering extending at least partially along the frame.
A61F 2/915 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles fabriquée à partir de feuilles perforées ou de tubes perforés, p.ex. perforés par découpe au laser ou gravés avec des bandes présentant une structure en méandre, des bandes adjacentes étant reliées l’une à l’autre
A right ventricular assist device (hereinafter "RVAD") for placement inside a mammalian subject includes a tube having an inlet configured to be positioned in the mammalian subject when the tube is in a proper position within a heart and an outlet configured to be located in a pulmonary artery when the tube is in the proper position. The RVAD also includes a plurality of sensors having measurement locations along the tube to measure a plurality of pressures of blood exterior to the tube at the measurement locations and a controller in communication with the pump and the plurality of sensors that convey the plurality of pressures to the controller with the controller being configured to instruct the pump to pump blood through the tube depending on at least one of the plurality of pressures.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
A61M 60/117 - Pompes extracorporelles, c.-à-d. que le sang est pompé à l’extérieur du corps du patient pour aider le cœur, p.ex. dans les dispositifs transcutanés ou d’assistance ventriculaire externe
A61M 60/13 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin au moyen d’un cathéter permettant l’explantation, p.ex. pompes à cathéter temporairement introduites par le système vasculaire
A61M 60/17 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables dans ou sur le cœur, ou autour du cœur à l’intérieur d’un ventricule, p.ex. pompes à ballon intra-ventriculaires
A61M 60/174 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables dans ou sur le cœur, ou autour du cœur à l’intérieur d’un ventricule, p.ex. pompes à ballon intra-ventriculaires refoulant le sang vers le ventricule ou le système artériel par une canule interne au ventricule ou au système artériel
A61M 60/861 - Connexions ou ancrages pour connecter ou ancrer les pompes ou dispositifs de pompage à des parties du corps du patient
A61M 60/867 - Dispositifs de guidage ou d’insertion de pompes ou dispositifs de pompage à l’intérieur du corps du patient utilisant la détection de la position pendant le déploiement, p.ex. pour les pompes pour le sang montées sur un cathéter et entraînées à travers celui-ci
8.
DEVICES AND METHODS FOR CONFIRMING TISSUE CAPTURE FOR A SHUNT DEVICE
A contrast delivery system for determining tissue capture of a shunt device (1506) includes a catheter (1540) including a lumen having a distal end, an exit hole connecting the lumen to an exterior surface of the catheter, and a side opening adjacent to the distal end of the lumen. The contrast delivery system further includes a tube (1542) slidably receivable in the lumen and configured to deliver a contrast agent, the tube including a closed distal terminal end, a first distal hole (1546A), and a proximal hole (1548). The first distal hole and proximal hole are spaced along a length of the tube, wherein the first distal hole is disposed between the proximal hole and the closed distal terminal end. The tube is configured to slide in the lumen between a plurality of positions.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p.ex. de remèdes, dans les cavités du corps
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A delivery device for delivering a shunt device within a human body, the delivery device includes a nosecone including a straight portion and a tapered portion, and a molded bridge coupled to the nosecone. The molded bridge includes a body, a notch extending into the body of the molded bridge, and a pocket extending into the body of the molded bridge. The pocket is positioned on an opposite side of the molded bridge as the notch. The molded bridge further includes a plurality of lumens positioned within and extending at least partially through the body of the molded bridge.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 17/20 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour la vaccination ou le nettoyage de la peau avant la vaccination
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
10.
CIRCULATION MANAGEMENT THROUGH BLOOD VESSEL REMODELING
An implant device includes an elongated stent structure forming an axial flow channel therethrough. The stent structure has a shape-memory that biases the stent structure to a bent configuration, such that the stent structure is configured to return to the bent configuration after manipulation to a straightened configuration of the stent structure.
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
11.
COMPRESSIBLE-GAS-FILLED IMPLANT WITH LIQUID BUFFER
An implant device includes a first chamber containing a compressible gas medium and a second chamber separated from the first chamber by a first membrane portion, the second chamber containing an at least partially liquid medium.
A system for regulating blood flow through a blood vessel of a heart, the system comprising a valve comprising an outer frame and configured for placement at least partially within the blood vessel.
A61M 60/135 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe
A61M 60/531 - Régulation par des données du patient en temps réel par des données de tension artérielle, p.ex. provenant de capteurs de tension
A61M 60/861 - Connexions ou ancrages pour connecter ou ancrer les pompes ou dispositifs de pompage à des parties du corps du patient
A61M 60/892 - Vannes actives, c. à d. actionnées par une force externe
A61M 60/90 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails non prévus dans les groupes , ou
13.
DELIVERY DEVICE FOR CONFIRMING TISSUE CAPTURE OF A SHUNT DEVICE
A device for delivering a shunt device within a human body, the shunt device having a central flow tube, a proximal arm, and a distal arm, the proximal arm and distal arm configured to capture a tissue wall therebetween. The delivery device includes a catheter that includes a tube and a side opening. The delivery device further includes a flexible wire slidably receivable in the tube and extendable into the side opening. The flexible wire includes a tip at a distal end configured to deflect upon contact with human tissue. The flexible wire is disposed outside of the central flow tube of the shunt device.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
14.
CURVED OUTER SHEATH FOR A SHUNT DEVICE DELIVERY DEVICE
An outer sheath for surrounding and covering components of a delivery device includes a straight section including an aperture extending fully through the straight section. The outer sheath further includes a pre-curved section extending distally from an end of the straight section and including an aperture extending fully through the pre-curved section. The straight section and the pre-curved section include a varying stiffness along a length of the straight section and the pre-curved section.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A delivery device for implanting a shunt device in a tissue wall includes an actuation arm extending through the delivery device, the actuation arm configured to seat an arm of the shunt device on the tissue wall, and a wavy release wire extending through the actuation arm, wherein the wavy release wire includes a wavy portion that forms a friction fit with the actuation arm.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A shunt device is configured to be inserted into a puncture in a tissue wall that defines a horizontal reference plane. The shunt device includes a shunt body. The shunt body includes a central flow tube extending from a first axial end to a second axial end and defining a central axis therethrough that is angled from a reference axis extending perpendicular through the horizontal reference plane; a flow path extending through the central flow tube; and a plurality of arms extending outward from the central flow tube and configured to secure the shunt device to the tissue wall. The plurality of arms includes a first distal arm and a second distal arm attached to the first axial end of the central flow tube and a first proximal arm and a second proximal arm attached to the second axial end of the central flow tube.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
17.
SYSTEMS AND METHODS FOR RESPONSIVE DAMPING OF PRESSURE
Systems and methods for responsively damping pressure pulsations are provided. Generally, a responsive damping system can comprise one or more responsive dampeners, responsive dampeners can include a means for damping pressure pulsations via a pressure resistor.
The devices and methods disclosed herein relate to providing an accurate and direct measure of vessel distensibility. These direct measures can also simultaneously record invasive pressures and provide a precise PWV calculation. The disclosed devices include a catheter that is easily inserted under fluoroscopic guidance through the femoral or radial artery. The disclosed devices enable physicians to diagnose aortic stiffness and to provide a direct measure of aortic compliance.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
19.
METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING BLOOD CIRCULATORY HEMOGLOBIN
A method and system for non-invasively determining continuous total hemoglobin data is provided. The method includes a) using a near infra-red spectrophotometric (NIRS) sensing device on a continuous basis to sense a subject's tissue, the sensing producing NIRS signals; and b) determining continuous total hemoglobin (THb) using the produced NIRS signals.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
G01N 21/359 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
An implant device comprises a stent frame having an oval cross-sectional shape and a fluid-tight covering disposed on a portion of the stent frame. Such implant devices can include a first end portion having a circular cross-sectional shape and a medial portion having a non-circular cross-sectional shape.
A61F 2/915 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles fabriquée à partir de feuilles perforées ou de tubes perforés, p.ex. perforés par découpe au laser ou gravés avec des bandes présentant une structure en méandre, des bandes adjacentes étant reliées l’une à l’autre
An aperture valve for maintaining hemostasis extends from a proximal end to a distal end along a primary axis. The aperture valve includes a proximal ring situated at the proximal end and formed of rigid material, a distal ring situated at the distal end and formed of rigid material, a flexible cylinder surrounding the primary axis, attached to and axially overlapping with the proximal ring and the distal ring, and a locking mechanism selectively anchoring the proximal ring to the distal ring. The flexible cylinder is irisable by rotation of the proximal ring relative to the distal ring. The locking mechanism is engageable to retain the flexible cylinder in an irised state by locking the proximal ring to the distal ring while the proximal ring is rotated relative to the distal ring.
Capsule loading assist apparatuses and associated methods. A capsule loading assist apparatus can comprise a lead screw, a loading assist nut, and a torque transfer mechanism. The loading nut comprises a capsule engagement surface configured to engage a delivery capsule of a delivery apparatus to exert a loading assist force on the delivery capsule. The capsule loading assist apparatus is configured such that rotating the lead screw in a first lead screw direction causes the loading assist nut to move along the lead screw in a distal direction. A capsule loading assist assembly can comprise a delivery apparatus, a prosthetic heart valve, and a capsule loading assist apparatus. A method can comprise operatively coupling a delivery apparatus to a capsule loading assist apparatus with a loading assist nut and rotating a capsule translation knob of the delivery apparatus to translate the loading assist nut in a distal direction.
A hemodynamic monitor includes a non-invasive blood pressure sensor and an integrated hardware unit with a system processor, a system memory, and a display with a user interface. The system memory includes instructions that are configured to: adjust, by a pressure controller, a pressure within an inflatable blood pressure bladder to maintain a constant volume of an artery of a patient for a period of time; generate an arterial pressure waveform data of the patient based on the adjusted pressure within the inflatable blood pressure bladder over the period of time; extract a plurality of signal measures from the arterial pressure waveform data of the patient; extract input features from the plurality of signal measures that are indicative of an ejection fraction score of the patient; and determine the ejection fraction score of the patient based on the extracted input features.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/0225 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres la pression étant commandée par des signaux électriques, p.ex. dérivés des bruits de Korotkoff
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
A method for treating heart failure comprises delivering an implant into a pericardial cavity of a heart using a delivery system, inflating the implant with a filling to expand the implant, and releasing the implant from the delivery system.
A hemodynamic monitor for detecting aortic stenosis includes a non-invasive blood pressure sensor and an integrated hardware unit with a system processor, a system memory, and a display with a user interface. The system memory includes instructions that, when executed by the system processor, are configured to adjust, by a pressure controller, a pressure within an inflatable blood pressure bladder. An arterial pressure waveform data of the patient is generated based on the adjusted pressure within the inflatable blood pressure bladder over the period of time and a plurality of signal measures are extracted from the arterial pressure waveform data of the patient. Input features are extracted from the plurality of signal measures that are indicative of an aortic stenosis score of the patient, and the aortic stenosis score of the patient is determined based on the extracted input features.
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/0225 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres la pression étant commandée par des signaux électriques, p.ex. dérivés des bruits de Korotkoff
A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A delivery apparatus for a prosthetic valve comprises a handle body, and shaft displacement and shaft adjustment mechanisms coupled to the handle body. The shaft displacement mechanism is configured to axially displace a shaft relative to the handle body. The adjustment mechanism is configured to adjust a curvature of the shaft and comprises a pull wire coupled to a distal end of the shaft. A first knob is operatively coupled to the shaft displacement mechanism and rotatable relative to the handle body, wherein rotating the first knob relative to the handle body simultaneously axially displaces the shaft and the pull wire relative to the handle body. A second knob is operatively coupled to the shaft adjustment mechanism and rotatable relative to the handle body, wherein rotating the second knob relative to the handle body adjusts the curvature of the shaft independent of an axial displacement of the shaft.
A system for dry storage of a bioprosthetic heart valve comprising a valve housing and a storage tray. The valve housing has a cavity that is dimensioned to retain the heart valve and permits the addition of a hydrating liquid prior to implantation. A lid is pivotably movable between open position and a closed position to enclose the heart valve with in the valve housing. The valve housing cavity is dimensioned to inhibit rotational and lateral movement of the bioprosthetic heart valve. The valve housing nests within a storage tray and mating surfaces position the valve housing in a specific orientation and help resist rotational movement of the valve housing relative to the storage tray. The storage tray has a gas- permeable membrane and the valve housing features apertures to permit passage of a sterilizing gas.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguins; Prothèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corps; Appareils pour les assujettir au corps; Dispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p.ex. stents
Introducers that can be used in combination with sheaths for introducing a delivery apparatus into a patient's vasculature, and methods for utilizing such introducers, are disclosed herein. As one example, an introducer (100) can include a nosecone (130), and inner shaft (120) attached to the nosecone, and outer shaft (110) disposed around the inner shaft, and a plug (150) disposed around the inner shaft. The plug is configured to expand from a first diameter in a compacted configuration thereof, to a second diameter in an expanded configuration thereof.
Docking devices for securing a prosthetic valve at a native valve and delivery apparatus for delivery thereof. The docking device includes a coil member. A guard member includes a plurality of fibers that can extend radially outward from an exterior surface of the coil. The guard member can be secured to the coil via one or more sutures. The guard member can be compressed within a dock sleeve during delivery of the docking device to the native valve. The dock sleeve can be withdrawn or axially moved relative to the coil member to allow the guard member to transition from the compressed state to the radially extended state. The guard member can function anchor a prosthetic valve and limit or prevent paravalvular leakage when implanted in a native heart valve.
The present disclosure relates to prosthetic valves, and in particular, to prosthetic heart valves that include non-uniform valvular structures coupled to the frames of such valves, wherein the non-uniform valvular structures include soft or malleable movable portions configured to freely transition between closed and open configurations, and stiffer portions exhibiting increased stiffness or rigidity relative to the movable portions.
A method of manufacturing an implantable medical device with radiopaque properties, the method includes converting an ingot of a metal alloy with radiopaque and super elastic properties into a rod. The method also includes drilling the rod to create a hollow tube. The method also includes drawing the tube. The method also includes manufacturing an implantable medical device form from the tube. The method also includes finishing the implantable medical device form to create an implantable medical device.
A delivery apparatus for implanting a prosthetic valve is disclosed. The prosthetic valve can comprise a mechanically actuatable frame comprising at least one actuator member, the actuator member configured to be rotated to radially expand or compress the frame. The delivery apparatus can comprise at least one actuator assembly configured to actuate the actuator member of the prosthetic valve, the actuator assembly comprising an outer sleeve member having a lumen and an inner driver member coaxially disposed within the lumen of the sleeve member, the driver member being rotatable relative to the sleeve member, wherein the actuator assembly is configured to be transitioned between an engaged state and a disengaged state with the prosthetic valve, and wherein the driver member is configured to be selectively magnetically coupled to the actuator member in the engaged state.
Devices are configured to be positioned within a native heart valve to impede regurgitation through the native heart valve. The devices can include one or more of an expandable coaptation element and/or an extension or blocking member. The expandable coaptation elements can be adjustable in size, shape, or both to control the area of the native heart valve that is filled by the coaptation element. The expandable coaptation elements, extensions, and/or blocking members can be positioned in the native heart valve, such that regurgitant blood flow is blocked or impeded.
Methods for attaching a component to a frame of a prosthetic heart valve are disclosed. As one example, a method includes forming a stitching line along an edge portion of an outer skirt for a prosthetic valve with in-and-out stitches that extend along the edge portion, spaced away from a free edge of the edge portion, and a plurality of loops that are spaced apart from one another in a direction of the in-and-out stitches, each loop circling around the free edge and extending between the edge and an intersection of two adjacent in- and-out stitches. The method further includes attaching the edge portion to struts of a frame of the prosthetic valve by extending whip stitches through the loops and around the struts such that the free edge is positioned against radially outward facing surfaces of the struts and away from leaflets arranged inside the frame.
Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A prosthetic valve is disclosed comprising an annular frame, a plurality of leaflets positioned within and coupled to the annular frame, each leaflet comprising a body portion having a free outflow edge and two opposing commissure portions on opposite sides of the leaflet, wherein each commissure portion is folded along a radially-extending fold line to form an inner fold layer and an outer fold layer, wherein each commissure portion is paired with a commissure portion of an adjacent leaflet to form a commissure that is coupled to the frame, and for each commissure, a retention member extending between the inner fold layer and the outer fold layer of a first commissure portion of the commissure and between the inner fold layer and the outer fold layer of a second commissure portion of the commissure to hold the first and second commissure portions together during working cycles of the prosthetic valve.
A clamping device for a catheter shaft can include a first member having a first indicator surface and defining a first inner bore having a non-circular cross-sectional profile, and a second member having a second indicator surface, and an extending annular element defining a second inner bore, the annular element received within the first inner bore and comprising an outer surface having a non-circular cross-sectional profile. The clamping device can be movable between a release state in which the second inner bore has a first diameter, and a clamped state in which the second inner bore has a second diameter less than the first diameter.
Expandable frames for prosthetic heart valves are disclosed. As one example, a prosthetic valve can include a frame comprising interconnected angled struts defining rows of cells between first and second ends of the frame, the stmts including a first row of struts at the first end, a second row of stmts, and a third row of struts. A first row of first cells is disposed at the first end and defined by the first and second rows of stmts and a second row of second cells is disposed adjacent to the first row of first cells and defined by the second and third rows of stmts, each first cell wider than each second cell, and the second row of struts comprising a plurality of free apex regions, each connecting adjacent ends of a respective pair of angled struts and having a first surface with a constant convex curvature.
Disclosed herein are sutures (or cords) and methods for using sutures wherein the sutures comprise a material or a combination of materials configured to increase echogenicity of the sutures. In some examples, the sutures comprise echogenic materials incorporated into suture material (e.g., ePTFE). In some examples, the sutures comprise a combination of materials with abrupt and relatively large changes in density to increase reflections of ultrasound waves. The disclosed sutures enhance echogenicity to increase visibility of the sutures using ultrasound imaging technologies. Furthermore, disclosed herein are methods that utilize the disclosed sutures in valve repairs including implanting artificial cords, sub-valvular techniques, reshaping organs, annuloplasty, and the like. Utilization of the disclosed echogenic sutures can result in superior outcomes due at least in part to physicians being able to better visualize the placement and/or tension of the echogenic sutures.
Leaflets for a prosthetic heart valve are disclosed. As one example, a leaflet includes a main body with a free, outflow edge and a cusp edge portion, two lower tabs disposed on opposite sides of the main body, where the cusp edge portion terminates at upper ends thereof at the lower tabs, and the lower tabs extend laterally outward from the main body relative to a central longitudinal axis of the leaflet, and two upper tabs disposed on opposite sides of and extending laterally outward from the main body. The leaflet further includes two offsetting portions, each extending between a respective lower tab and upper tab and offsetting the respective upper tab axially and laterally away from the outflow edge of the main body, where each upper tab has opposing inner and outer edges that are parallel to one another and the central longitudinal axis of the leaflet.
A delivery apparatus for implanting a prosthetic valve is disclosed. The delivery apparatus comprises at least one actuation assembly configured to actuate an actuator member of a prosthetic valve, the actuator member configured to be rotated via rotation of a head thereof to radially expand or compress a frame the prosthetic valve, the actuation assembly comprising: an outer sleeve member having a lumen, wherein a distal end portion of the sleeve member comprises internal threads; a driver member coaxially disposed within the lumen of the sleeve member, the driver member being rotatable relative to the sleeve member, wherein a distal end portion of the driver member comprises a socket configured to receive the head of the actuator member, wherein the actuation assembly is configured to be transitioned between an engaged position and a disengaged position with the frame.
A compliance restoration implant device includes a first compliant fluid container, a second compliant fluid container, and a conduit structure. The first compliant fluid container includes a first lumen that widens in response to fluid leaving the first compliant fluid container and narrows in response to the fluid entering the first compliant fluid container. The second compliant fluid container includes a second lumen that widens in response to the fluid leaving the second compliant fluid container and narrows in response to the fluid entering the second compliant fluid container. The conduit structure is coupled to the first compliant fluid container and the second compliant fluid container and is configured to pass fluid between the first compliant fluid container and the second compliant fluid container in response to changing pressure levels outside one of the fluid containers.
A61M 60/135 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe
A61M 60/139 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe à l’intérieur de l’aorte, p.ex. pompes à ballon intra-aortiques
A61M 60/295 - Pompes à ballon pour assistance circulatoire
A61M 60/30 - Leurs finalités médicales étant autres que l’amélioration du débit cardiaque
A61M 60/497 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails concernant l’entraînement pour les pompes à ballon d’assistance circulatoire
A61M 60/837 - Aspects des éléments de déplacement souples, p.ex. formes ou matériaux
A61M 60/869 - Chambres de compensation contenant un gaz ou un liquide autre que le sang pour compenser les variations de volume d’une chambre de sang
A61M 60/882 - Dispositifs mus par le patient, p.ex. dispositifs mus par muscle squelettique
A medical device is provided that includes a first scroll set. A first spindle of the scroll set is fixed relative to a target site and a second spindle is configured to move in relation to the first spindle. The device also includes a first covering material attached to the first spindle at a first end and the second spindle at a second end and is configured to be wound about at least one spindle. In an instance in which the second spindle moves in a direction opposite the first spindle, the first covering material is caused to be unwound from the second spindle. In some instances, the device also includes one or more cutting mechanisms to make an incision.
A packaging system includes a stackable tray for storing one or more implements. The stackable tray has one or more first interlocking features at a first surface of the tray and one or more second interlocking features at a second surface of the tray. The first stackable tray is arranged to mate with a second stackable tray via engagement of the first interlocking features or the second interlocking features when the first stackable tray is rotated from a first orientation to a second orientation.
B65D 21/04 - Réceptacles à extrémité ouverte conçus pour s'emboîter quand ils sont vides et être superposés quand ils sont pleins
B65D 63/10 - MANUTENTION; EMBALLAGE; EMMAGASINAGE; MANIPULATION DES MATÉRIAUX DE FORME PLATE OU FILIFORME ÉLÉMENTS D'EMBALLAGE; PAQUETS Éléments d'emballage flexibles allongés, p.ex. courroies pour lier ou pour soutenir des objets Éléments filamenteux, p.ex. cordons, fils ou fils métalliques; Jonctions de leurs extrémités
An implant device includes a frame having an axially bulging cylindrical form in an expanded configuration of the frame and a radially-expandable tube disposed within the frame.
A61M 60/135 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe
A61M 60/139 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe à l’intérieur de l’aorte, p.ex. pompes à ballon intra-aortiques
A61M 60/295 - Pompes à ballon pour assistance circulatoire
A61M 60/861 - Connexions ou ancrages pour connecter ou ancrer les pompes ou dispositifs de pompage à des parties du corps du patient
A61M 60/882 - Dispositifs mus par le patient, p.ex. dispositifs mus par muscle squelettique
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A system and method for determining a target physiologic parameter of a subject is provided. The method includes: sensing a subject with first, second, and third sensing devices respectively configured to sense first and second physiologic parameters and a target physiologic parameter during a period of time, and produce respective first and second physiologic data signals and target physiologic data signals; determining presence or absence of a confounding factor that taints a determination of the target physiologic parameter; advancing the first, second, and target physiologic data signals produced in the absence of the confounding factor for further processing, and setting aside the first, second, and target physiologic data signals produced in the presence of the confounding factor; and f) determining a value of the target physiologic parameter using the first, second, and target data signals produced in the absence of the confounding factor.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale
A61B 5/0205 - Evaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p.ex. de l'état cardiaque et respiratoire
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
Devices, systems, and/or methods can provide compliance characteristics to fluid vessels. For example, an implant device can include one or more anchoring structures configured to anchor the implant device to a fluid vessel. The implant device can also include a torsion element coupled to the one or more anchoring structures and configured to cause the implant device to apply a torsional force to at least a first anchoring structure of the one or more anchoring structures when the first anchoring structure is rotated away from a biased position.
A medical implant for managing blood flow through a blood vessel comprises a plug, a mounting ring, and one or more arms interconnecting the plug and the mounting ring, wherein the one or more arms are configured to allow movement of the plug relative to the mounting ring.
A system comprises a first obstruction element disposed at least partially within an inferior vena cava (IVC), superior vena cava (SVC), or hepatic vein of a heart, the first obstruction element configured to expand and compress in response to pressure changes in the heart.
A61M 60/135 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin à l’intérieur d’un vaisseau sanguin, p.ex. par greffe
A61M 60/295 - Pompes à ballon pour assistance circulatoire
A61M 60/31 - Leurs finalités médicales étant autres que l’amélioration du débit cardiaque pour améliorer la perfusion d’organes in vivo, p.ex. rétroperfusion
A61M 60/497 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails concernant l’entraînement pour les pompes à ballon d’assistance circulatoire
A61M 60/861 - Connexions ou ancrages pour connecter ou ancrer les pompes ou dispositifs de pompage à des parties du corps du patient
A61M 60/882 - Dispositifs mus par le patient, p.ex. dispositifs mus par muscle squelettique
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
The present disclosure relates to inflatable balloons designed to permit blood flow through channels formed along and optionally around their outer surfaces. Such a balloon can include least two lobes spiraling around the balloon's axis and along the length of the central portion, and at least two depressed portions extending between the helical lobes. When the balloon is inflated within a target lumen, helical channels are provided between the depressed portions and an inner surface of the target lumen to allow blood to flow through the channels and across the balloon. The balloon can be inflated in a gradual manner, optionally based at least in part on measurements from one or more sensor(s) that can be attached to the balloon, such as flow sensors configured to measure flow through the helical channels, and/or force sensors configured to measure force applied against the balloon during inflation thereof.
A medical system comprises an electronically controlled actuator system and a catheter system for providing access within a body cavity. The electronically controlled actuator system includes a plurality of carnages mounted with a frame and movable along a longitudinal axis with respect to the frame, and a carriage drive system configured to adjust a position of each of the carriages. The catheter system includes a distal end, a proximal end, a plurality of lumens extending between the distal end and the proximal end, and a plurality of adapters. Each of the adapters can be coupled to a corresponding carriage and attach to a lumen such that adjusting the position of the corresponding carriage actuates the attached lumen. The actuator system has a control system with executable instructions to control the plurality of carriages and therefore the lumens of the catheter system.
A method and system for predicting a limit to a subject's autoregulation range is provided. The method includes: a) determining blood flow values representative of a subject's blood flow in an autoregulation range of the subject during a period of time; b) determining blood pressure values representative of the subject's blood pressure in the autoregulation range of the subject during the period of time; c) determining a mathematical function that represents the blood flow values versus the blood pressure values within the autoregulation range; d) using the mathematical function to produce a representation of the blood flow values versus the blood pressure values outside of the autoregulation range; and e) predicting a limit to the autoregulation range using the representation of the blood flow values versus the blood pressure values outside of the autoregulation range.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale
An implant comprises a first rail, a second rail, and one or more curved members extending between the first rail and the second rail and coupled to inner surfaces of the first rail and the second rail, wherein the first rail and the second rail comprise outer surfaces configured to contact one or more blood vessel walls.
A61F 2/844 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p.ex. stents repliés avant déploiement
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
An implant device includes a frame having an axially bulging cylindrical form in an expanded configuration of the frame and a radially-expandable tube disposed within the frame.
Devices, systems, and/or methods discussed herein relate to medical device packaging that facilitates sterilization or other processes for the medical devices disposed within the packaging. For example, medical device packaging can include a gas-permeable channel that is configured to permit a gas to enter/exit the packaging where a medical device located, while preventing a microorganism from entering/exiting the packaging. The gas-permeable channel can be implemented within/as part of a seal of the packaging, a surface of the packaging, and/or elsewhere. The gas-permeable channel can include a tortuous path or a path that is longer than a predetermined threshold to inhibit/prevent a microorganism from contaminating the medical device.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 50/00 - Récipients, étuis, mobilier ou supports spécialement adaptés aux appareils ou aux instruments chirurgicaux ou de diagnostic, p.ex. étuis stériles
A medical infusion system can comprise an infusion cannula comprising a cannula shaft having an infusion lumen extending therethrough that is configured to slidably receive a guidewire, and a cannula catheter comprising a catheter shaft having a catheter lumen extending therethrough. The catheter lumen can comprise a first lumen portion extending from a proximal end of the catheter shaft to a side opening on a distal portion of the catheter shaft, at least a portion of the cannula shaft being configured to be slidably disposed in the first lumen portion and a distal portion of the cannula shaft being configured to be advanced out of the first lumen portion through the side opening. The catheter lumen can comprise a second lumen portion extending distally from the first lumen portion to a distal end of the catheter shaft, the second lumen portion being configured to slidably receive the guidewire.
A compliance-restoration device includes a first elastic band biased to a contracted state and configured to longitudinally stretch and store energy in response to pulling forces, a first tissue anchor coupled to a first end of the first elastic band, and a second tissue anchor coupled to a second end of the elastic band.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour la suture des plaies; Supports ou emballages pour aiguilles ou matériaux de suture
58.
BALLOON ASSEMBLIES WITH INFLATABLE TOROID BALLOONS
The present disclosure relates to balloon assemblies designed to permit blood flow through a central perfusion channel, at least when blood flows in a proximally-oriented direction. Such a balloon assembly can include one or more toroid balloons, each defining a cavity that can be independently fed by one or more inflation tubes coupled thereto to inflate the balloon. When the toroid balloons are inflated within a patient lumen or a prosthetic device, such as a prosthetic heart valve, blood is allowed to flow through the perfusion lumen. A balloon assembly can further include a flexible valve configured to regulate blood flow when the balloon assembly is inflated, to allow proximally directed flow through a channel formed in a flexible funnel thereof, and prevent backflow in the opposite direction.
Methods and assemblies for attaching a radiopaque marker to an attachment member of a commissure of a prosthetic valve are disclosed. As one example, a prosthetic heart valve can comprise a frame including struts forming cells of the frame, at least one commissure comprising an attachment member and commissure tabs of two adjacent leaflets coupled thereto, the attachment member arranged across a cell of the frame and attached to struts defining the cell, and a radiopaque marker suspended within the cell and against the attachment member by sutures. The sutures extend from a first portion of the attachment member, through one or more apertures in the marker, and to a second portion of the attachment member, the sutures forming two knots in the second portion that are disposed on opposite sides of the marker such that the sutures form a non-crossing X-pattern through the marker and across the attachment member.
In some examples, a prosthetic heart valve for implantation within a native heart valve includes a radially expandable frame and a valvular structure. The frame includes an annular main body having an inflow end and an outflow end. The main body is radially expandable between a radially compressed state and a radially expanded state. The valvular structure includes a plurality of leaflets disposed within and coupled to the frame. The frame includes a plurality of frame anchors coupled to the main body. Each frame anchor is configured to be positioned on or around a pair of free edges of two of the native leaflets of the native heart valve. In some examples, a prosthetic heart valve delivery assembly includes a prosthetic heart valve and a delivery apparatus for delivering the prosthetic heart valve to an implantation site.
Medical procedures and devices that use bioimpedance-based feedback are disclosed. Bioimpedance-based feedback can include measuring or acquiring electrical signals that include or indicate a bioimpedance signal. The bioimpedance signal can be used to determine the position and/or status of device (e.g., of a clasp or anchor of the device) and/or tissue near the device. The bioimpedance signal can be analyzed and converted into information presented to a clinician to indicate a status of a portion of a device to provide feedback regarding the position and/or status of the device, for example, anchoring elements of an implant. Some devices enable the removal of electrodes or electrical leads when the device is implanted.
In some examples, a medical implant includes a frame and a radiopaque marker. The radiopaque marker is coupled to the strut with a recessed surface portion of the radiopaque marker positioned in opposing relation to a first concave surface of a strut portion of the frame. In some examples, at least one strut of the frame has a bore, an eyelet, and a strut portion between the bore and the eyelet. The radiopaque marker is disposed within the bore and has an edge surface with a recessed surface portion positioned in opposing relation to a first surface of the strut portion. In some examples, a medical assembly includes a delivery apparatus, a frame, and a radiopaque marker.
A leaflet subassembly for a prosthetic heart valve can include a leaflet having a cusp edge portion and opposite major surfaces. A reinforcing structure can be attached to the leaflet along the cusp edge portion. The reinforcing structure can include a first reinforcing member and a second reinforcing member arranged on the opposite major surfaces of the leaflet. A prosthetic heart valve can include a frame and a leaflet subassembly. The leaflet subassembly can include a leaflet and a reinforcing structure attached to the leaflet along a cusp edge portion of the leaflet. The cusp edge portion can be coupled to the frame via the reinforcing structure. A method of assembling a prosthetic heart valve can include disposing a leaflet at least partially within a frame and attaching the leaflet to the frame by extending a suture through reinforcing members attached to opposite major surfaces of the leaflet.
Systems and methods for reconstructing radial arterial pressure are provided. Noninvasive arterial pressure data derived from a finger or thumb can be transformed into a radial arterial pressure. Computational models can be trained and utilized to predict the parameters to transform finger or thumb arterial pressure into radial arterial pressure.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
A system includes a hardware unit that stores signal distortion detection code. The code causes the system to execute steps of a method for evaluating the fit and placement of a hemodynamic sensor. The method includes obtaining hemodynamic data from the hemodynamic sensor and determining an arterial pressure waveform based on the hemodynamic data. A distortion score is determined based on one or more features extracted from the arterial pressure waveform and a weighting module. The method includes selectively invoking a sensory alarm based on a comparison of the distortion score to a predetermined criterion or predetermined criteria.
A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
67.
SYSTEMS AND METHODS FOR SCREENING AND PREDICTING SEPSIS
Systems and methods for assessment of sepsis using a waveform data and/or other patient information are provided. The waveform data corresponds to a signal, for example, from an arterial blood pressure, or any signal proportional to, or derived from the arterial pressure signal. These systems and methods involve extracting hemodynamic data features from the waveform data and entering the hemodynamic data features into predictive computational models, to yield scores that can be utilized to screen for an early indication of sepsis or can be utilized to predict a probability that an individual is experiencing sepsis.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
68.
SYSTEMS AND METHODS OF FOR COMPUTER-ASSISTED MEASUREMENT OF PULMONARY CAPILLARY WEDGE PRESSURE
Systems and methods for computer-assisted analysis of pulmonary capillary wedge pressure (PCWP) measurement acquisition in an individual are provided. Various systems and methods measure a wedge pressure via a pulmonary catheter and determine the quality of the wedge pressure measurement. In some instances, systems and methods utilize a trained computational model to assess PCWP quality. Systems and methods are also directed to determining transitions between a wedge and non-wedge positions, which may utilize fuzzy logic to identify such transitions based on a one or more hemodynamic features.
A prosthetic valve can include an annular frame that is radially expandable and compressible, a skirt member attached to the annular frame, and a protective member attached to an inner surface the skirt member. The protective member is less abrasive than the skirt member and extends circumferentially around at least a portion of the annular frame.
Prosthetic valve preparation assemblies and associated methods are disclosed herein. A crimper assembly can include a first crimp stop and a second crimp stop that define respective ranges of motion of an actuator handle. A method of mounting an implantable prosthetic valve to a valve delivery apparatus can include inserting a balloon catheter within the implantable prosthetic valve, partially crimping an annular frame of the implantable prosthetic valve, positioning a crimp alignment tool in an alignment configuration relative to the valve delivery apparatus, positioning the implantable prosthetic valve to engage the crimp alignment tool, and fully crimping the annular frame.
The present disclosure relates to a method and corresponding system for a non-invasive determination of a physiological parameter, the method (400) comprising: applying (410) a first pressure cuff (150) to a limb of a living subject, in particular of a human being; applying (420) a second pressure cuff (104) distally to the first pressure cuff (150) to the limb of the subject; inflating (430) the first pressure cuff (150) to a pressure value exceeding a first threshold value; monitoring (440) a pressure signal of the second pressure cuff (104) after the step of inflating the first pressure cuff (150); deriving (450) a measure indicative of mean systemic filling pressure, MSFP, from the monitored pressure signal of the second pressure cuff (104).
A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
Systems, devices and methods of valvular prosthetics having one or more bioresorbable components are described. The bioresorbable components can resorb overtime, allowing the ingrowth of tissue in and around the valvular prosthetic. Systems, devices and methods of valvular prosthetics for mitigating stagnation of blood flow are also described. Generally, various alternative mechanisms are described that propel stagnated blood underneath leaflet and near the luminal wall away from the wall such that it can flow through the outflow end of the valvular prosthetic.
Apparatuses, systems, and methods for prosthetic valves. An implantation site may comprise a native heart valve or another implantation site in examples. Examples may be utilized for improved anchoring and sealing of flow (e.g., paravalvular leakage) with a native heart valve having calcification. Examples may include breaking up calcification of a native heart valve to improve deployment to the native heart valve.
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
Leaflet perforation tools and associated methods. A leaflet perforation tool can comprise a catheter, a lacerating member configured to pierce a leaflet to form a pilot puncture, and an expansion member configured to expand the pilot puncture into a leaflet opening. In another example, a leaflet perforation tool can comprise a catheter and a nosecone that comprises at least one blade. The nosecone can form a leaflet opening in a leaflet, and blade can form a leaflet slit that is connected to the leaflet opening. A method can comprise forming a leaflet opening within a leaflet with a leaflet perforation tool, positioning a replacement prosthetic valve within the leaflet opening, and radially expanding the replacement prosthetic valve. A method also can comprise forming a pilot puncture within a leaflet and expanding the pilot puncture into a leaflet opening.
The disclosure relates to a method (100) for notifying a clotting event in an arterial line (1 ) of a human being (2), to a corresponding system, computer program product and data carrier signal. The method (100) comprises providing (110) a hemodynamic signal indicative of an arterial blood pressure waveform (10) in the arterial line (1 ); determining (120) a hemodynamic contraction parameter related to a contraction of the heart based on the hemodynamic signal; determining (130) a hemodynamic relaxation parameter related to a relaxation of the heart based on the hemodynamic signal; determining (140) a clotting event in the arterial line (1 ) in case the hemodynamic contraction parameter indicates a decrease of contractility and the hemodynamic relaxation parameter indicates an increase of contractility, and providing (150) a signal notifying of the determined clotting event.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A prosthetic heart valve includes a valve frame comprising an outflow end and an inflow end, a plurality of leaflets disposed within and coupled to the valve frame, and a skirt assembly mounted to an outer surface of the valve frame. The skirt assembly includes a sealing layer and a skirt frame including a plurality of interconnected struts, wherein the skirt frame has a plurality of inflow apices and outflow apices, wherein selected ones of the inflow apices are fixed to the valve frame and selected ones of the outflow apices are fixed to the valve frame, wherein one or more of the struts are configured to flex in an outward radial direction when the valve frame is in a radially expanded state to cause the sealing layer to protrude outwardly from the valve frame.
The present disclosure relates to prosthetic valves that include information indicators which can indicate suitable information associated with a previously implanted prosthetic valve. Such information indicators can be internally formed in relatively wide support posts of mechanically expandable prosthetic valve, or can be externally formed along support posts of mechanically expandable prosthetic valve or vertical struts of balloon expandable prosthetic valves.
Suture lock assemblies with suture tensioners are disclosed herein. A suture lock assembly can comprise a suture tensioner configured to be selectively rotated to collect a length of a suture. The suture tensioner comprises a pair of spaced-apart posts and a connecting body coupled to each of the posts. A suture lock assembly also can comprise a suture tensioner, a tensioner housing, and a quick release suture mechanism. The tensioner housing at least partially receives the suture tensioner and includes a suture entry port and a suture exit port. The suture tensioner is configured to be selectively rotated relative to the tensioner housing to selectively increase a length of a suture that is enclosed by the tensioner housing. The quick release suture mechanism comprises a quick release dock port and a suture anchor cap configured to be selectively coupled to and uncoupled from the quick release dock port.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour la suture des plaies; Supports ou emballages pour aiguilles ou matériaux de suture
80.
QUICK RELEASE SUTURE MECHANISMS AND SUTURE LOCK ASSEMBLIES INCLUDING THE SAME
Quick release suture mechanisms for a suture lock assembly are disclosed herein. A quick release suture mechanism can comprise a suture anchor cap. The quick release suture mechanism is configured to be coupled to a suture and is configured to be selectively transitioned between a locked configuration, in which the quick release suture mechanism maintains the suture in a fixed position relative to the quick release dock port, and an unlocked configuration, in which the suture may be removed from the quick release dock port. A suture lock assembly can comprise a spool configured to engage a suture and a quick release suture mechanism configured to be coupled to the suture. The quick release suture mechanism comprises a quick release dock port, a suture anchor cap, and a dock port coupling mechanism configured to selectively couple the suture anchor cap to the quick release dock port.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour la suture des plaies; Supports ou emballages pour aiguilles ou matériaux de suture
Reinforcement members for an outer skirt of a prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include an annular frame and an outer skirt disposed around an outer surface of the frame, the outer skirt including a sealing layer comprising an outflow edge portion secured to the frame and an inflow edge portion secured to the frame and a deformable reinforcement member attached to the sealing layer. The reinforcement member extends circumferentially along the sealing layer and is configured to extend radially outward from the frame such that the sealing layer bulges radially outward and away from the frame when the frame is radially expanded from a radially compressed state to a radially expanded state. The reinforcement member comprises a circumferentially extending row of cells or an undulating shape.
A delivery apparatus configured to deliver a prosthetic implant can include a handle, a first shaft extending through the handle, and a second shaft that is coaxial with the first shaft and surrounds at least a proximal end portion of the first shaft. The second shaft can include an outer shaft member positioned proximal to the handle and an inner shaft member that is axially movable relative to the outer shaft member. The second shaft can be movable between an axially extended configuration and an axially collapsed configuration. When the second shaft is in the axially extended configuration, the inner shaft member can extend into the handle. When the second shaft is in the axially collapsed configuration, the inner shaft member can be positioned proximal to the handle.
Apparatuses, systems, and methods for prosthetic valves. An implantation site may comprise a native heart valve or another implantation site in examples. Examples may be utilized for improved anchoring and sealing of flow (e.g., paravalvular leakage) with a native heart valve having calcification. Examples may reduce the possibility of obstruction of a left ventricular outflow tract (LVOT) of a heart, whether resulting from implantation of a prosthetic valve or otherwise.
An implantable device or implant is configured to be positioned within a native heart valve to allow the native heart valve to form a more effective seal. The implantable device or implant can expand and contract. For example, the implantable device or implant can narrow during delivery and expand on implantation on the native heart valve.
Prosthetic valves that include support arms extending from support posts thereof, and methods for utilizing such prosthetic valves, are disclosed herein. As one example, a prosthetic valve can include an annular frame movable between a radially compressed state and a radially expanded state, and at least one support arm. The frame can include a plurality of support posts, each extending between a post inflow end and an opposite post outflow end. The support arm can extend from a corresponding support post, and terminate at a free-ended tip which is biased radially away from the corresponding support post.
Catheter shafts that can be used in a delivery apparatus for a prosthetic implant are disclosed. As one example, a catheter shaft can include a tube having a distal end portion comprising at least one axially extending slot, the slot extending proximally into the tube from a distal end of the tube and radially through a thickness of the tube. The catheter shaft can further include a polymeric layer comprising a jacket portion disposed around the tube, a tip portion extending distal to the jacket portion and the tube, and a channel portion disposed within the slot; and an inner liner disposed on an inner surface of the tube and an inner surface of the tip portion, where a material of the polymeric layer bonds with the inner liner.
Outer skirts for a prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include an annular frame and an outer skirt disposed around an outer surface of the frame. The outer skirt can include a first portion comprising a polymeric material and a second portion comprising a fabric, where the polymeric material has a greater thromboresistance than the fabric. The second portion is secured to an inflow end of the frame and extends toward an intermediate portion of the frame and the first portion extends from the second portion and toward an outflow end of the frame
A prosthetic heart valve configured to be expanded within a native valve annulus, engage surrounding tissue, and constricted tissue inward to enhance contact between the tissue and the valve. The heart valve may have a structural valve stent with an outer constricting structure having tissue-engaging members. The constricting structure may be intrinsic or extrinsic. One intrinsic version includes a plurality of arms that are arranged to constrict inward toward a central valve portion, or a fabric structure with tissue anchors and surrounding an inner valve member may be cinched to pull the tissue inward.
A stabilizer for use with a delivery system is provided. The stabilizer receives a delivery system, such as a handle portion, and prevents unwanted movement of the delivery system during a medical procedure. The stabilizer preferably includes an elongate rail that is adapted to be secured to a base or table. A rail dock is adapted to releasably couple to the delivery system. The rail dock is slidably mounted along an upper surface of the rail and includes a brake assembly. The brake assembly preferably includes a toggle member with at least one push button, wherein actuation of the push button may release or lock the brake assembly. Components of the stabilizer are provided for allowing the stabilizer to be used with different delivery systems and the stabilizer is capable of being secured to different sized tables.
Devices and methods for selectively directing fluid flow through lumens of a catheter in order to effectively flush and/or de-air specified lumens of the catheter are disclosed. As one example, an assembly comprises a catheter including a first shaft and a second shaft extending through the first shaft. The assembly further comprises a sealing mechanism including a first seal disposed around a distal end portion of the first shaft, a second seal disposed, around a portion of the second, shaft that extends distal to the first shaft, and a cavity disposed within a housing of the sealing mechanism between the first seal and the second seal. A distal end of the first, shaft is disposed within the cavity and the cavity is fluidly sealed by the first seal and the second seal such that fluid from a first lumen of the first shaft cannot exit the cavity.
A cardiovascular implant device includes an expandable annular frame and a flow conditioner. The expandable annular frame is formed of a plurality of struts and is configured to conform to an interior shape of a blood vessel or a chamber of a heart when expanded inside the blood vessel or the chamber of the heart. The flow conditioner is connected to the plurality of struts of the expandable annular frame. The flow conditioner is positioned to modify a hemodynamic characteristic of a flow of blood through or out of the expandable annular frame.
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
Extension members for an outer skirt of a prosthetic heart valve and methods for unfolding the extension members during radial expansion of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve comprises a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration, and an outer skirt disposed around an outer surface of the frame. The outer skirt comprises one or more extension members that are movable between a first state where the one or more extension members are folded against the frame and a second state where the one or more extension members extend radially outward and away from the frame, and where the one or more extension members are in the first state when the frame is in the radially compressed configuration and in the second state when the frame is in the radially expanded configuration.
A catheter includes a magnetic release mechanism comprising a magnet located within a distal region of a lumen of the catheter. A spacer wall encloses the lumen within the distal region of the lumen. The magnet abuts the spacer wall between the spacer wall and a proximal end of the catheter. A catheterization procedure includes guiding the catheter to an attachment point and rotating a handle of the catheter to thereby rotate the magnet, which induces rotation of an implant retained at the distal end of the catheter by the magnet. Disengaging the magnetic release mechanism decouples the implant from the catheter.
A shunt device includes a shunt body formed of a plurality of struts and a flow conditioner connected to the plurality of struts of the shunt body. The shunt body includes a central flow tube, a flow path extending through the central flow tube, and a plurality of arms extending outward from the central flow tube and configured to secure the shunt device to a tissue wall. The flow conditioner is positioned to modify a hemodynamic characteristic of a flow of blood through or out of the central flow tube.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
95.
CARDIAC SHUNT DEVICE TO MINIMIZE DISRUPTION TO AND ENHANCE NATURAL FLOW PATTERNS OF BLOOD THROUGH THE HEART
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A medical device comprising an incision assembly (500) coupled to a distal end of a catheter (129), and an introducer coupled to and projecting from the incision assembly is described and disclosed. A method of improving a heart function in a heart of a subject having heart dysfunction, the method comprising creating at least one incision length through a pericardium, and reducing pressure exerted by the pericardium on a heart is also described and disclosed.
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
97.
PERICARDIAL TRANSECTION DEVICE WITH RETRACTABLE CUTTING APPARATUS
A medical device that includes an incision device configured to be operably coupled to a distal end of a catheter is described. The incision device includes an incision channel defined along the incision device. The device also includes a retractable cutting apparatus disposed within the incision channel. The retractable cutting apparatus includes a first cutting apparatus link (310) that is rotatably fixed proximate to a distal end of the incision channel and a second cutting apparatus link (315) that is attached to the first link proximal end of the first cutting apparatus link (310). The retractable cutting apparatus also includes a guide member (130) coupled to cause the retractable cutting apparatus to move between a retracted position and a deployed position. The retractable cutting apparatus further also includes a first blade attached to the first link proximal end of the first cutting apparatus link.
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A method of improving a heart function in a heart of a subject having heart dysfunction is described, the method comprising creating at least one incision length through a pericardium; and reducing pressure exerted by the pericardium on a heart.
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A device and method of providing access support, the device includes an elongated body, a support tube slidably arranged within the elongated body, where the device has a first configuration and a second configuration so as to allow access of a device through the support tube. A method of delivering devices are also disclosed.
Systems and devices for accessing an inner space between two tissues are provided. A system can comprise a helical coil within a catheter delivery system. The helical coil can be delivered to the procedure site at which point it can be turned to penetrate and traverse tissue to reach an inner space. The system can further comprise a gas supply system for providing gas to help displace one or both tissues to create more access space within the inner space between the two tissues. A tool, prosthetic, or other device can be transferred via the catheter system into the inner space to perform a procedure therein.
brevets
