Abrégé

Provided herein are engineered terminal deoxynucleotidyl transferase (TdT) proteins with certain modifications, including mutations to confer thermal stability and to install an exposed amino acid residue to which a small molecule can be covalently tethered via bioconjugate chemistries such as click chemistry. Also provided herein are methods of nucleic acid molecule synthesis using engineered TdTs and nucleotide molecules attached to redox-cleavable linkers, wherein the engineered TdT incorporates the nucleotide molecule into a nucleic acid strand and is separated from the nucleotide molecule when the redoxcleavable linker is cleaved upon exposure to suitable electrochemical conditions. Also provided herein are engineered TdTs covalently attached to a nucleotide molecule via a tether and also nucleotide molecules comprising a redox-cleavable linker. Further provided herein are systems for enzymatic DNA synthesis comprising an engineered TdT, a redox-cleavable linker a redox shuttle solution, and two or more electrodes.

Classes IPC  ?

• C12P 19/34 - Polynucléotides, p.ex. acides nucléiques, oligoribonucléotides
• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
• C07H 19/10 - Radicaux pyrimidine avec le radical saccharide estérifié par des acides phosphoriques ou polyphosphoriques
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p.ex. kinases (2.7)
• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une composition; Formation de conjugaisons d'enzymes
• C25B 3/00 - Production électrolytique de composés organiques
• C40B 80/00 - Groupes de liaison ("linkers") ou bras-espaceurs ("spacers") spécialement adaptés à la chimie combinatoire ou aux chimiothèques, p.ex. "linkers" de type "traceless" ou "safety-catch"

Abrégé

A system for calorimetry includes a plurality of wells disposed upon a well plate, an input feature to deposit a sample within each well, and light sources configurable to irradiate each of the wells in the well plate, and their samples, with incident light. A photonic sensor chip at a bottom of each well includes a plural nanohole array sensor on a substrate. A light detector positioned below the well is configured to measure the transmission of light through the sensors, obtaining a series of optical transmission measurements. A heater is in thermal contact with each of the wells, applying a transient thermal increase to each well, and the sample therein, at a known heat rate. A processor is configured to calculate a measurement for each well as a function of the series of optical transmission measurements and the transient thermal increase, the measurement being indicative of the sample within the well undergoing a change in response to the transient thermal increase, the change relating to a property of the sample.

Classes IPC  ?

• G01N 25/48 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant la production de quantités de chaleur, c. à d. la calorimétrie, p.ex. en mesurant la chaleur spécifique, en mesurant la conductivité thermique sur une solution, sorption ou réaction chimique n'impliquant pas une oxydation par combustion ou catalyse
• G01N 33/15 - Préparations médicinales

Abrégé

A system can include a balloon catheter, a pump, a pressure sensor, and one or more processors, The balloon catheter can be configured to be inserted into a lumen of a tissue. The pump can be configured to provide fluid into the balloon catheter to cause the balloon catheter to induce a radial stress of the tissue. The pressure sensor can be configured to detect a pressure of the fluid while the balloon catheter is inducing the radial stress of the tissue. The one or more processors can be configured to determine a characteristic of the tissue based at least on the pressure.

Classes IPC  ?

• A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci

Abrégé

A method of acoustophoresis using selection particles that alter acoustic response is provided. The method can include selecting a set of selection particles based on surface markers of a plurality of target particles to be separated using acoustophoresis. The method can include incubating the set of selection particles with the plurality of target particles in a solution such that the set of selection particles bind with the surface markers on the plurality of target particles to create a plurality of bound particles. The method can include providing the plurality of bound particles to an acoustophoresis device tuned to separate the particles based on a net acoustic contrast between each of the plurality of bound particles. The method can include receiving a plurality of output streams from the acoustophoresis device that each include a respective bound particle of the plurality of bound particles.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillon; Méthodes pour isoler physiquement un micro-organisme intact
• G01N 1/40 - Concentration des échantillons

Abrégé

A Fano resonator device can be used to sequence DNA or other macromolecules. The device includes customized molecular components, informed by computation analysis. Techniques for preparing and using the device also are disclosed. The device can be incorporated in a system that further includes a sample processing component and a flow chamber.

Classes IPC  ?

• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p.ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
• G01N 27/327 - Electrodes biochimiques
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

Devices for treatment of cells are disclosed. The devices include an elongated housing and at least one hollow fiber semi-permeable membrane positioned within the housing having a plurality of pores dimensioned to prevent passage of the cells to be treated. Systems for treatment of cells including the device are disclosed. Methods of treating cells, including transducing cells and activating cells, are also disclosed. The methods include introducing a biosample with cells to be treated into the device, introducing media to suspend and release treated cells into the device, and discharging the treated cells from the device.

Classes IPC  ?

• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/26 - Inoculateur ou échantillonneur
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.

Classes IPC  ?

• A61L 31/02 - Matériaux inorganiques
• A61F 2/24 - Valvules de cœur
• A61L 31/04 - Matériaux macromoléculaires
• A61L 31/10 - Matériaux macromoléculaires
• A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 31/16 - Matériaux biologiquement actifs, p.ex. substances thérapeutiques

Abrégé

A method for separating cells in a biofluid includes pretreating the biofluid by introducing a predetermined amount of a cocktail of antibodies, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the pretreated biofluid within the microfluidic separation channel. A system for microfluidic cell separation, capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of an additive including the cocktail of antibodies, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic cell separation is also disclosed. A method of facilitating separation of cells is also disclosed.

Classes IPC  ?

• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• G01N 1/40 - Concentration des échantillons
• B01D 15/38 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p.ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale

Abrégé

The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

The systems and methods of the present disclosure provide techniques for the design and use of an intermediate or transitional plate or block designed to couple acoustic energy at a given frequency from a transducer, such as a piezoelectric transducer, to one or more acoustophoretic devices, such as microfluidic channels, such that driving the chip occurs with a controlled wavelength and symmetry. Such techniques provide improved efficiency when driving a single acoustophoretic device, or for multiple acoustophoretic devices to be operated in concert from a single transducer, and therefore without complex electronics. Additionally, the techniques described herein allow for relaxed design constraints when considering transducer selection and fabrication, instead transferring design constraints to the more easily customized actuation plate.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

A microchannel cell culture device is disclosed. The microchannel cell culture device includes a well plate defining an array of tissue modeling environments. A cell culture system including the microchannel cell culture device is also disclosed. The cell culture system includes a plurality of optical sensors, a platform, and a light source. A method of high throughput screening cell biological activity with the microchannel cell culture device is disclosed. A method of measuring oxygen consumption rate of cells in the microchannel cell culture device is disclosed. A method of facilitating drug development with the microchannel cell culture device is also disclosed.

Classes IPC  ?

• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique

Abrégé

An antenna system has a two-dimensional field of view, yet can be implemented on a surface, such as on electronic or photonic integrated circuits. The antenna system includes an array of antennas disposed in a predetermined non-linear pattern and a two-dimensional beamforming network (BFN). The antenna system can be steered/selectively beamformed in two dimensions through beam port selection. The beamforming network is disposed entirely on a single first surface. The beamforming network has a one-dimensional array-side interface disposed on the first surface and a one-dimensional beam-side interface disposed on the first surface. The antennas of the array of antennas are individually communicably coupled to the array-side interface. Segments of the beam-side interface map to respective pixels in the two-dimensional field of view.

Classes IPC  ?

• H01Q 3/40 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante faisant varier la phase par des moyens électriques avec une matrice faisant varier l'angle de déphasage
• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles
• H01Q 25/00 - Antennes ou systèmes d'antennes fournissant au moins deux diagrammes de rayonnement
• H04B 7/06 - Systèmes de diversité; Systèmes à plusieurs antennes, c. à d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission

Abrégé

Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products.

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
• C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
• C02F 3/34 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout caractérisé par les micro-organismes utilisés

Abrégé

The present disclosure provides a handpiece (100) for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump (1104) and a fluid reservoir (1106). The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.

Classes IPC  ?

• A61F 11/00 - Procédés ou dispositifs pour le traitement des oreilles ou de l'ouie ; Prothèses auditives non électriques; Procédés ou dispositifs permettant au patient d’obtenir une perception auditive par des sens physiologiques autres que l’ouïe; Dispositifs de protection pour les oreilles, portés sur le corps ou dans la main

Abrégé

A system for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous-flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to one another to perform various unit operations in the cell bioprocessing or cell-therapy manufacturing chain to enable direct processing of a blood or blood product sample. The system can automatically and continuously process the sample into genetically-modified lymphocytes or T cells for cellular therapy. The technologies implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoretic media exchange or cell washing, and continuous-flow microfluidic electrotransfection. Modules implementing these microfluidic technologies can be interconnected with plastic tubing or with a custom manifold.

Classes IPC  ?

• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The present solution provides systems and methods for trans-round window membrane drug delivery. As an overview, a system can include a micropump that is connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce the round window membrane of a patient. Using the handpiece, the cannula can be inserted through the round window membrane to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-round window membrane drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.

Classes IPC  ?

• A61F 11/00 - Procédés ou dispositifs pour le traitement des oreilles ou de l'ouie ; Prothèses auditives non électriques; Procédés ou dispositifs permettant au patient d’obtenir une perception auditive par des sens physiologiques autres que l’ouïe; Dispositifs de protection pour les oreilles, portés sur le corps ou dans la main
• A61M 5/142 - Perfusion sous pression, p.ex. utilisant des pompes
• A61B 17/34 - Trocarts; Aiguilles à ponction

Abrégé

A method for manufacturing a microfluidic device can include providing a base component to define a first portion of the microfluidic device. A cap component of the microfluidic device can be fabricated with a sealing lip extending a first distance from a first side of the cap component and a support portion extending a second distance, less than the first distance, from the first side of the cap component. The method can include positioning the cap component and the base component within a mold to bring the sealing lip of the cap component in contact with the base component. The base component, the support portion of the cap component, and the sealing lip of the cap component together can define a cavity. The method can include injecting a polymer material into the mold to cause the polymer material to fill the cavity.

Classes IPC  ?

• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B81C 3/00 - Assemblage de dispositifs ou de systèmes à partir de composants qui ont reçu un traitement individuel

Abrégé

MEMS-actuated optical switches can be implemented on photonic chips. These switches are compact, essentially planar, simple to implement and include only one moving MEMS component per switch. The switches exhibit low optical loss, require low power to operate, and are simple to control and easy to integrate with other optical devices. Each switch has two optical waveguides that are optically coupled in an ON switch state and not coupled in an OFF switch state. An end or a medial section of one of the two waveguides may translate between the ON and OFF states to affect the coupling. Alternatively, a coupling frustrator may translate between the ON and OFF states to affect the coupling.

Classes IPC  ?

• G02B 6/35 - Moyens de couplage optique comportant des moyens de commutation
• G02B 6/12 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES - Détails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p.ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré

Abrégé

This disclosure provides systems and methods for integrating an array of electronic sensors capable of performing trans-epithelial electrical resistance (TEER) measurements into a microfluidic device that includes a well plate. In some implementations, the sensors can include electrodes that are submerged into fluidically connected wells of the microfluidic device, which can contain an electrically conductive fluid such as the cell culture media or a buffered salt solution. An array of such electrodes can be integrated into a lid of the system that includes the microfluidic device. These electrodes can be routed using a printed circuit board through a number of multiplex switches that can allow addressing of a desired unit of the device through a microprocessor in communication with a computer.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

This disclosure provides systems and methods for seeding cell cultures in a microfluidic device. The systems and methods of this disclosure can enable flow of a cell solution from one side of a scaffold, such as a porous substrate or membrane, to the other side of the scaffold. Flow of the liquid can pass through the scaffold while the cells themselves do not, resulting in the cells driven to the surface of the scaffold for consequent attachment. A microfluidic device can include a microfluidic feature structured to create a seal between a cell seeding tool and an inlet to a microchannel of the microfluidic device. This can enable a pressure-driven flow to push fluid down the channel and through pores of the membrane. In contrast, traditional gravity fed seeding of cells may not create enough pressure to drive fluid through the pores of the scaffold.

Classes IPC  ?

• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

Abrégé

A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse

Abrégé

A LiDAR system (300) has a field of view (320) and includes a polarization-based waveguide splitter (308). The splitter (308) includes a first splitter port (306), a second splitter port (312) and a common splitter port (316). A laser (302) is optically coupled to the first splitter port (306) via a single-polarization waveguide (304). An objective lens (334) optically couples each optical emitter (326-330) of an array of optical emitters (322) to a respective unique portion of the field of view (320). An optical switching network (340) is coupled via respective dual-polarization waveguides (338) between the common splitter port (316) and the array of optical emitters (322). An optical receiver (314) is optically coupled to the second splitter port (312) via a dual-polarization waveguide (310) and is configured to receive light (336) reflected from the field of view (320). A controller (342), coupled to the optical switching network (340), is configured to cause the optical switching network (340) to route light from the laser (302) to a sequence of the optical emitters (326-330) according to a temporal pattern.

Classes IPC  ?

• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• G01S 7/499 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant des effets de polarisation
• G02B 6/26 - Moyens de couplage optique

Abrégé

A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern in a way that reduces risk of eye injury from the laser light.

Classes IPC  ?

• G01S 17/08 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement
• G02B 6/35 - Moyens de couplage optique comportant des moyens de commutation

Abrégé

A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern based at least in part on distance to an object within the field of view. The LiDAR system scans different portions of the field of view differently, such as with different laser power levels, different revisit rates and/or different scan patterns, for example based on likelihood of detecting objects of interest in the various portions or based on likely relative importance of objects likely to be found in the various portions.

Classes IPC  ?

• G01S 17/08 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement
• G02B 6/35 - Moyens de couplage optique comportant des moyens de commutation

Abrégé

In an embodiment, a method and system use various sensors to determine a shape of a collection of materials (e.g., foodstuffs). A controller can determine a trajectory which achieves the desired end-state, possibly chosen from a set of feasible, collision-free trajectories to execute, and a robot executes that trajectory. The robot, executing that trajectory, scoops, grabs, or otherwise acquires the desired amount of material from the collection of materials at a desired location. The robot then deposits the collected material in the desired receptacle at a specific location and orientation.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• B25J 19/00 - Accessoires adaptés aux manipulateurs, p.ex. pour contrôler, pour observer; Dispositifs de sécurité combinés avec les manipulateurs ou spécialement conçus pour être utilisés en association avec ces manipulateurs

Abrégé

A problem with current food service robots is making the robots safe to work around food. A solution provided by the present disclosure is a food-safe tool switcher and corresponding tool. The tool switcher can mate with a variety of tools, which can be molded or 3D printed out of food-safe materials into a single-part, instead of constructed modularly. This provides for easier cleaning.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• B23Q 3/155 - Agencements pour insérer ou retirer automatiquement les outils

Abrégé

In an embodiment, a method includes determining a given material to manipulate to achieve a goal state. The goal state can be one or more deformable or granular materials in a particular arrangement. The method further includes, for the given material, determining, a respective outcome for each of a plurality of candidate actions to manipulate the given material. The determining can be performed with a physics-based model, in one embodiment. The method further can include determining a given action of the candidate actions, where the outcome of the given action reaching the goal state is within at least one tolerance. The method further includes, based on a selected action of the given actions, generating a first motion plan for the selected action.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

In an embodiment, a method during execution of a motion plan by a robotic arm includes determining a voice command from speech of a user said during the execution of the motion plan, determining a modification of the motion plan based on the voice command from the speech of the user, and executing the modification of the motion plan by the robotic arm.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

An adaptor (200) comprising an element having a first interface component (404) and second interface component (415) wherein the first interface component (404) is configured to removably mate with a connector (112) of a robot (110) and the second interface component (415) is configured to attach to a tool (108).

Classes IPC  ?

• B25J 11/00 - Manipulateurs non prévus ailleurs
• A47J 43/28 - Autres instruments à main de cuisine, p.ex. spatules, pinces, fourchettes ou articles similaires pour tenir les aliments, cuillères à pots, cuillères d'écumage, cuillères de cuisine; Supports de cuillères fixés aux marmites

Abrégé

In an embodiment, a method includes identifying a force and torque for a robot to accomplish a task and identifying context of a portion of a movement plan indicating motion of the robot to perform the task. Based on the identified force, torque, and context, a context specific torque is determined for at least one aspect of the robot while the robot executes the portion of the movement plan. In turn, a control signal is generated for the at least one aspect of the robot to operate in accordance with the determined context specific torque.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• A47J 44/00 - Machines à usages multiples pour préparer la nourriture

Abrégé

Embodiments provide functionality to prevent collisions between robots and objects. An example embodiment detects a type and a location of an object based on a camera image of the object, where the image has a reference frame. Motion of the object is then predicted based on at least one of: the detected type of the object, the detected location of the object, and a model of object motion. To continue, a motion plan for the robot is generated that avoids having the robot collide with the object based on the predicted motion of the object and a transformation between the reference frame of the image and a reference frame of the robot. The robot can be controlled to move in accordance with the motion plan or a signal can be generated that controls the robot to operate in accordance with the motion plan.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

In an embodiment, a cover for an automated robot includes elastic sheets that are adhered to each other in a geometry. The geometry is configured to allow the elastic sheets to expand and contract while the automated robot moves within its range of motion. The elastic sheets are attached to the automated robot by elasticity of the elastic sheets. A first group of the elastic sheets forms an elastic collar configured to grip the automated robot at a distal end and a proximal end of the cover. A person of ordinary skill in the art can recognize that nonbreakably means that during operation of the robot, the elastic sheets hold their elasticity and integrity without breaking.

Classes IPC  ?

• B25J 19/00 - Accessoires adaptés aux manipulateurs, p.ex. pour contrôler, pour observer; Dispositifs de sécurité combinés avec les manipulateurs ou spécialement conçus pour être utilisés en association avec ces manipulateurs

Abrégé

Embodiments provide methods and systems to modify motion of a robot based on sound and context. An embodiment detects a sound in an environment and processes the sound. The processing includes comparing the detected sound to a library of sound characteristics associated with sound cues and/or extracting features or characteristics from the detected sound using a model. Motion of a robot is modified based on a context of the robot and at least one of: (i) the comparison, (ii) the features extracted from the detected sound, and (iii) the characteristics extracted from the detected sound.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

In an embodiment, a method for handling an order includes determining a plurality of ingredients based on an order, received from a user over a network, for a location having a plurality of robots. The method further includes planning at least one trajectory for at least one robot based on the plurality of ingredients and utensils available at the location, and proximity of each ingredient and utensil to the at least one robot. Each trajectory can be configured to move one of the plurality of ingredients into a container associated with the order. In an embodiment, the method includes executing the at least one trajectory by the at least one robot to fulfill the order. In an embodiment, the method includes moving the container to a pickup area.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• B25J 11/00 - Manipulateurs non prévus ailleurs

Abrégé

Current technologies allow a robot to acquire a tool only if the tool is in a set known location, such as in a rack. In an embodiment, a method and corresponding system, can determine the previously unknown pose of a tool freely placed in an environment. The method can then calculate a trajectory that allows for a robot to move from its current position to the tool and attach with the tool. In such a way, tools can be located and used by a robot when placed at any location in an environment.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• B25J 11/00 - Manipulateurs non prévus ailleurs

Abrégé

Transfer of genetic and other materials to cells is conducted in a hands-free, automated, high throughput, continuous process. A system using a microfluidic hydrodynamic sheath flow configuration includes arrangements for pushing cells from side streams containing a cell culture medium to a central stream containing an electroporation buffer. Electroporation can be conducted in an assembly in which two or more microfluidic channels are provided in a parallel configuration and in which various layers can be stacked together to form a laminate type structure.

Classes IPC  ?

• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

A well reader and actuator (100) for a well array (50) has an array of detectors, each detector for detecting a fluorescence signal from fluorophores in a respective well of the well array and an excitation subsystem for exciting the fluorophores in the wells of the well array. Embodiments of this invention can be used to carry out two important functions in a highly parallel manner: by addressing individual wells in a 32, 96, 384 etc. well array, where each well contains a potential chemical or biological reaction. The two functions are: 1) through thermal, optical or other means and combinations thereof the rate of a chemical or biological reaction is controlled or gated (e.g. colder wells inhibit a reaction, or an enzymatic reaction requires blue light to proceed); and 2) through use of fluorescent species that are sensitive to the target reaction - or reactions - an optical readout of fluorescent intensity and/or lifetime is tracked to monitor the evolution of the reaction.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

Local terrain feature location data is obtained from a local sensor device at a user location without a prior-known global position. The local terrain feature location data characterizes relative distances and directions to a plurality of local terrain features nearest to the user location. Global terrain feature location data stored in at least one hardware memory device is accessed. The global terrain feature location data characterizes relative distances and directions between a plurality of distinctive terrain features located in a defined terrain region in terms of absolute global location coordinates. The local terrain feature location data is compared to the global terrain feature location data to develop multiple pattern matching hypotheses, wherein each pattern matching hypothesis characterizes a likelihood of a subset of the local terrain features matching a subset the global terrain features. Global location coordinates for the user location is then determined from the pattern matching hypotheses.

Classes IPC  ?

• G01S 5/16 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de position; Localisation par coordination de plusieurs déterminations de distance utilisant des ondes électromagnétiques autres que les ondes radio
• G01S 17/46 - Détermination indirecte des données relatives à la position
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01C 21/00 - Navigation; Instruments de navigation non prévus dans les groupes

Abrégé

The present disclosure describes a system, device and method for differentiating cells such as, for example, generating ex vivo common lymphoid progenitors (CLPs) from human hematopoietic stem cells (HSCs). The system and method can be fully automated requiring minimal touch input from a user. Once harvested, the CLPs can be transplanted into a patient for cellular immune therapy.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/0789 - Cellules souches; Cellules progénitrices multipotentes

Abrégé

A method of lidar processing pulses a scene with laser pulse sequences from a laser light source. Reflected light (201) from the target scene (105) passes through receiver optics (202) and is defocused to cover a light sensing surface (205) of a photo detector array (204). The photo detector array (204) contains multiple photon detector elements connected in parallel where each photon detector element is configured to generate corresponding photon pulse output signals based on sensing photons in the received reflected light, and each photon detector element is characterized by a non-responsive dead time period immediately after sensing a photon. The defocused light (203) is intended to spread the optical power of the incoming light over many of the individual photo detectors. The photon pulse output signals are combined to form a common real time output signal, which is converted to a digital time resolved histogram. Multiple digital time resolved histograms produced in response to multiple light pulses directed at a scanning location are combined to form a composite time resolved histogram for the scanning location. In an embodiment, the receiver optics (202) is a lens having a focal plane positioned beyond the light sensing surface (205) so that defocused light (203) hits and covers the light sensing surface (205). A high speed analog-to-digital converter (206) converts the signal to a digital indication of a number of photons received in each time bin. A lidar processor (207) can combine the digital time resolved histograms for the scanning location into a composite time resolved histogram for the location.

Classes IPC  ?

• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques

Abrégé

A method of lidar imaging pulses a scene with laser pulse 102 sequences from a laser light source 101. A receiver detector 108 converts the received reflected light 107 into a time-resolved signal for each of the laser pulses. Reflected light from the scene is measured for each laser pulse to form a sequence of time resolved light signals. Adjoining time bins in the time resolved light signals are combined to form super time bins. A three dimensional image of the scene is created from distances determined based on maximum intensity super time bins. One or more objects 105 are located within the image using a detection algorithm. For each object 105, the time resolved light signals are combined by summing or averaging to form a single object time resolved light signal from which to determine distance to the object. This process can be applied to the original sized time bins of the time resolved light signals to recover the high speed temporal resolution. In addition, measuring the reflected light also may include detrending or high-pass filtering the time resolved light signals to offset scattering effects due to fog or other interfering factors which may obscure an ability to obtain precise distances, and to isolate the sharp return from the target object in the measured reflected light.

Classes IPC  ?

• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• G01S 7/486 - Récepteurs
• G01S 7/487 - Extraction des signaux d'écho désirés
• G01S 17/93 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour prévenir les collisions

Abrégé

A parallelized chain-synthesizing technique includes capillary tubes, where each tube provides multiple locations or addresses where a specific arbitrary sequence for polymeric chains can be synthesized. An optical addressing system selectively delivers light to the locations to mediate or control reactions in the tubes.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
• G06N 3/12 - Agencements informatiques fondés sur des modèles biologiques utilisant des modèles génétiques

Abrégé

An embedded energy storage system comprises an array of embedded storage solar cells and a panel combiner/converter configured to combine and coordinate the array of embedded storage solar cells. Each of the array of embedded storage solar cells may comprise a solar cell having a first surface that is light receptive and a second surface that is not light receptive, an array of micro super-capacitors (MSCs) disposed on a substrate, and one or more integrated circuit components disposed on the same or different substrate. If disposed on different substrates, the two substrates may be intimately connected using an advanced packaging technology. The substrate may be arranged to overlay the second surface of the solar cell, substantially adjacent to the second surface, with two or more electrical conductors configured to electrically couple the substrate to the solar cell.

Classes IPC  ?

• H02S 40/38 - Moyens de stockage de l’énergie, p.ex. batteries, structurellement associés aux modules PV
• H01L 31/053 - Moyens de stockage d’énergie directement associés ou intégrés à la cellule PV, p.ex. condensateur intégré avec une cellule PV

Abrégé

A system for sequential exposure of particles to different fluid streams includes an acoustic actuator device for acoustically driving one or more substrates and a microchannel device of the one or more substrates that receive particles in a first flowing fluid, moves the particles to a second flowing fluid, then moves the particles out of the second flowing fluid using acoustic radiation generated by the acoustic actuator device. The system can control residence times in the streams. According to one use, the first flowing fluid is a cell buffer and the second flowing media is an electroporation buffer. An electroporation system is placed in or downstream of the acoustic actuator device. However, in other uses, the second flowing media might be a wash buffer.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

A viral transduction and/or electroporation device has s a membrane separating two chambers and two electroporation electrodes for the chambers. An electrical voltage source is used for establishing an electrical field across the membrane and between the two electrodes. In operation, fluid is flowed into the chambers including fluid containing electroporation cargo and viral transduction solution and an electrical field is established across the membrane and between the electrodes to electroporate cells pinned to the membrane and transfecting the cells.

Classes IPC  ?

• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

A system and method of LIDAR imaging to overcome scattering effects pulses a scene with light pulse sequences from a light source. Reflected light from the scene is measured for each light pulse to form a sequence of time-resolved signals. Time-resolved contrast is calculated for each location in a scene. A three-dimensional map or image of the scene is created from the time-resolved contrasts. The three-dimensional map is then utilized to affect operation of a vehicle.

Classes IPC  ?

• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 7/48 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• G01S 17/93 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour prévenir les collisions

Abrégé

An electrostatic motor includes a cylindrical rotor and a stator. Electrodes are disposed on an inside cylindrical surface of the stator. Electrets and/or electrically conductive electrodes are disposed on the cylindrical rotor and a dielectric fluid fills space between the rotor and the stator to prevent discharge of the electrets. A mask is used to charge portions of an electret cylinder or other curved surface.

Classes IPC  ?

• H02N 1/00 - Générateurs ou moteurs électrostatiques utilisant un porteur mobile de charge électrostatique qui est solide

Abrégé

A system and method of processing instructions may comprise an application processing domain (APD) and a metadata processing domain (MTD). The APD may comprise an application processor executing instructions and providing related information to the MTD. The MTD may comprise a tag processing unit (TPU) having a cache of policy-based rules enforced by the MTD. The TPU may determine, based on policies being enforced and metadata tags and operands associated with the instructions, that the instructions are allowed to execute (i.e., are valid). The TPU may write, if the instructions are valid, the metadata tags to a queue. The queue may (i) receive operation output information from the application processing domain, (ii) receive, from the TPU, the metadata tags, (iii) output, responsive to receiving the metadata tags, resulting information indicative of the operation output information and the metadata tags; and (iv) permit the resulting information to be written to memory.

Classes IPC  ?

• G06F 21/52 - Contrôle des usagers, programmes ou dispositifs de préservation de l’intégrité des plates-formes, p.ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade de l’exécution du programme, p.ex. intégrité de la pile, débordement de tampon ou prévention d'effacement involontaire de données
• G06F 12/0875 - Adressage d’un niveau de mémoire dans lequel l’accès aux données ou aux blocs de données désirés nécessite des moyens d’adressage associatif, p.ex. mémoires cache avec mémoire cache dédiée, p.ex. instruction ou pile
• G06F 12/14 - Protection contre l'utilisation non autorisée de mémoire
• G06F 15/76 - Architectures de calculateurs universels à programmes enregistrés
• G06F 9/30 - Dispositions pour exécuter des instructions machines, p.ex. décodage d'instructions
• G06F 9/38 - Exécution simultanée d'instructions
• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• G06F 21/71 - Protection de composants spécifiques internes ou périphériques, où la protection d'un composant mène à la protection de tout le calculateur pour assurer la sécurité du calcul ou du traitement de l’information

Abrégé

A system including at least one processor programmed to translate a policy into policy code, wherein: the policy is provided in a policy language; the policy code is in a programming language that is different from the policy language; and the policy includes a statement that maps an entity name to one or more metadata symbols to be associated with an entity in a target system against which the policy is to be enforced.

Classes IPC  ?

• G06F 21/12 - Protection des logiciels exécutables
• G06F 8/41 - Compilation
• G06F 9/445 - Chargement ou démarrage de programme
• G06F 8/54 - Transformation de programme Édition de liens avant le chargement
• G06F 21/51 - Contrôle des usagers, programmes ou dispositifs de préservation de l’intégrité des plates-formes, p.ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade du chargement de l’application, p.ex. en acceptant, en rejetant, en démarrant ou en inhibant un logiciel exécutable en fonction de l’intégrité ou de la fiabilité de la source
• G06F 21/52 - Contrôle des usagers, programmes ou dispositifs de préservation de l’intégrité des plates-formes, p.ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade de l’exécution du programme, p.ex. intégrité de la pile, débordement de tampon ou prévention d'effacement involontaire de données

Abrégé

A method for identifying an interaction between a pathogen and a biological agent includes providing a platform for supporting cell growth, seeding different interaction sites on the platform with different biological agents, perfusing the platform with a fluid that carries substances for promoting growth and maintenance of the cells, exposing all of the interaction sites to a solution containing viruses, and detecting evidence indicative of the interaction, the evidence comprising evidence indicative of a change in structure or composition of a medium at the interaction site. The biological agent includes cells alone or cells with another substance.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés

Abrégé

A system for providing biphasic stimulation is disclosed. The system includes an electrode, an antenna coupled to a transmitter, a capacitor, a power supply, a backscatter load selectively coupled to the antenna via a switching device, a plurality of switches, and a controller configured to control the switching device to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power. The controller is further configured to control the plurality of switches to electrically couple a first plate of the capacitor to the electrode to provide a first nerve stimulation signal having a first polarity, and electrically couple a second plate of the capacitor to the electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity. The system further includes a housing encapsulating the antenna, the capacitor, the power supply, the backscatter load, the switches, and the controller.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/378 - Alimentation en courant électrique

Abrégé

A coupling interface arrangement is described for a photonic integrated circuit (PIC) device. The PIC includes an interface coupling surface having optical grating elements arranged to form optical output locations that produce corresponding light output beams. A coupling lens couples the light output beams into a conjugate plane at a far-field scene characterized by one or more optical aberrations that degrade optical resolution of the light outputs. The optical grating elements are configured to correct for the one or more optical aberrations.

Classes IPC  ?

• G02B 6/124 - Lentilles géodésiques ou réseaux intégrés

Abrégé

This invention provides a system and method for background removal from images acquired by an ultrasound scanner in the presence of molecularly bound contrast agent. The system and method employs novel techniques that are compatible with the real-world constraints (i.e. energy levels, duration of exam, geometries involved, etc.) of imaging in mammalian tissue (e.g. tissues of human organs containing lesions/tumors), while providing the dramatically improved signal clarity required to reliably disambiguate contrast agent from other sources of signal intensity.

Classes IPC  ?

• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
• G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61K 49/22 - Préparations pour échographie; Préparations pour imagerie par ultrasons
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

This invention provides a system and method for guiding a surgical instrument based on information obtained using enhanced contrast-mode ultrasound. The enhanced information can be added to information or images obtained in one or more imaging modes. Various pieces of information can be combined and composited, including information regarding tumors, blood vessels, location information, confidence levels, and other information, and can be composited into operative imaging.

Classes IPC  ?

• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
• G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
• A61K 49/22 - Préparations pour échographie; Préparations pour imagerie par ultrasons
• A61B 8/06 - Mesure du débit sanguin

Abrégé

A MEMS optical switch-based LiDAR beam steering unit may comprise an optical switching array comprising two or more translatable optical switch gratings. The two or more translatable optical switch gratings may be arranged in a foveal pattern. Each of the two or more translatable optical switch gratings may have an associated MEMS structure operative to selectively translate the optical switch grating between a first position and a second position, and a first waveguide associated with the translatable optical switch grating. The grating being in the first position may cause the grating to be sufficiently close to the first waveguide to produce a strong optical coupling between the grating and the first waveguide. The grating being in the second position may cause the grating to be sufficiently far from the first waveguide to produce a weak optical coupling between the grating and the first waveguide.

Classes IPC  ?

• G02B 6/35 - Moyens de couplage optique comportant des moyens de commutation

Abrégé

According to various aspects and embodiments, a prosthetic valve assembly for controlling fluid flow in an annulus is provided. The prosthetic valve assembly includes a suture ring formed from two or more segments, where each segment is configured to attach to the annulus, and a leaflet subassembly that attaches to an inner portion of at least one segment of the suture ring. The leaflet subassembly includes at least one leaflet configured for controlling a flow of fluid through the prosthetic valve assembly.

Classes IPC  ?

• A61F 2/24 - Valvules de cœur

Abrégé

A system of two or more implantable medical devices is configured to establish a wireless link between the two or more implantable medical devices and a device external to a body of a patient while the two or more implantable medical devices are implanted in the body of the patient.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A software instruction code repair system comprising an instruction code example pool. The example pool comprises a set of good instruction code examples and a set of bad instruction code examples. The software instruction code repair system further comprises a sequence-to-sequence (seq2seq) network that is configured to generate a corrected instruction code example, based on one example of the set of bad instruction code examples. The software instruction code repair system further comprises a discriminator configured to randomly select one of the corrected instruction code example and one instruction code example of the set of good instruction code examples to produce a selected instruction code example. The discriminator is further configured to make a determination that the selected instruction code example is most likely taken either the instruction code example pool or the seq2seq network.

Classes IPC  ?

• G06F 11/36 - Prévention d'erreurs en effectuant des tests ou par débogage de logiciel

Abrégé

A non-volatile memory device (VeSFlash) comprises a vertical slit field effect transistor (VeSFET) device comprising a semiconductor portion defining a source end, a drain end, and a slit portion between the source end and the drain end. The VeSFlash non-volatile memory device further comprises at least one floating gate coupled to a side of the slit portion through an insulating layer. The floating gate is coupled to a contact through a second insulating layer. The VeSFlash non-volatile memory device further comprises either another floating gate or an independent control gate. In the case of comprising a control gate coupled to a side wall of the slit portion through a third insulating layer, and the control gate further coupled to a second contact, it is configured to accommodate an access signal, and the floating gate configured to accommodate a data signal. In the case of comprising a second floating gate coupled to a side of the slit portion through a third insulating layer, further coupled to a second contact through a fourth insulating layer, the floating gates accommodate both the access and data signals.

Classes IPC  ?

• H01L 29/788 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée à grille flottante
• H01L 29/66 - Types de dispositifs semi-conducteurs
• H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée

Abrégé

A method of fabricating a semiconductor device comprises forming, within a single process flow on a silicon on insulator (SOI) wafer, at least one of an n channel, digital VeSFET, a p channel, digital VeSFET, an n channel, analog VeSFET and a p channel, analog VeSFET. The method may further comprise forming, on the SOI wafer, at least one of a JFET, a BJT and a LT-MOM capacitor. The method may further comprise forming the n channel, digital VeSFET, a p channel, digital VeSFET, an n channel, analog VeSFET, and a p channel, analog VeSFET, according to a periodic design based on a unit circle. The method may comprise modifying a design of the semiconductor node, according to a three-dimensional architecture, to form a modified semiconductor node, and fabricating the modified semiconductor node on substrate, along with at least one other node of a different node type.

Classes IPC  ?

• H01L 21/84 - Fabrication ou traitement de dispositifs consistant en une pluralité de composants à l'état solide ou de circuits intégrés formés dans ou sur un substrat commun avec une division ultérieure du substrat en plusieurs dispositifs individuels pour produire des dispositifs, p.ex. des circuits intégrés, consistant chacun en une pluralité de composants le substrat étant autre chose qu'un corps semi-conducteur, p.ex. étant un corps isolant
• H01L 27/12 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant autre qu'un corps semi-conducteur, p.ex. un corps isolant
• H01L 29/735 - Transistors latéraux
• H01L 29/66 - Types de dispositifs semi-conducteurs
• H01L 49/02 - Dispositifs à film mince ou à film épais
• H01L 27/06 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant une pluralité de composants individuels dans une configuration non répétitive
• H01L 21/8249 - Technologie bipolaire et MOS
• H01L 27/085 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ

Abrégé

Transfer of genetic and other materials to cells is conducted in a hands-free, automated and continuous process that includes flowing the cells between electroporation electrodes to facilitate delivery of a payload into the cells, while acoustophoretically focusing the cells. Also described is a control method for the acoustophoretic focusing of cells that includes detecting locations of cells flowing through a channel, such as with an image analytics system, and modulating a drive signal to an acoustic transducer to change the locations of the cells flowing in the channel. Finally, an electroporation driver module is described that uses a digital to analog converter for generating an electroporation waveform and an amplifier for amplifying the electroporation waveform for application to electroporation electrodes.

Classes IPC  ?

• A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
• B01L 1/00 - Enceintes; Chambres
• A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation

Abrégé

This invention provides a system and method to propagate uncertainty information in a deep learning pipeline. It allows for the propagation of uncertainty information from one deep learning model to the next by fusing model uncertainty with the original imagery dataset. This approach results in a deep learning architecture where the output of the system contains not only the prediction, but also the model uncertainty information associated with that prediction. The embodiments herein improve upon existing deep learning-based models (CADe models) by providing the model with uncertainty/confidence information associated with (e.g. CADe) decisions. This uncertainty information can be employed in various ways, including (a) transmitting uncertainty from a first stage (or subsystem) of the machine learning system into a next (second) stage (or the next subsystem), and (b) providing uncertainty information to the end user in a manner that characterizes the uncertainty of the overall machine learning model.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

A single photon detection circuit is described that includes a germanium photodiode that is configured with zero voltage bias to avoid dark current output when no photon input is present and also is configured to respond to a single photon input by generating a photovoltaic output voltage. A single electron bipolar avalanche transistor (SEBAT) has a base emitter junction connected in parallel with the germanium photodiode and is configured so that the photovoltaic output voltage triggers an avalanche collector current output.

Classes IPC  ?

• H01L 31/111 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par au moins trois barrières de potentiel, p.ex. photothyristor
• H01L 31/02 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails
• H01L 31/028 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des éléments du groupe IV de la classification périodique

Abrégé

The present solution provides trans-round window membrane (RWM) drug delivery. As an overview, the system can include a micropump that is connected to a flexible cannula. The cannula can include a stiffened and sharpened tip to facilitate insertion through the RWM. The cannula can be inserted through the RWM to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-RWM drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p.ex. utilisant des pompes
• A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
• A61F 11/00 - Procédés ou dispositifs pour le traitement des oreilles ou de l'ouie ; Prothèses auditives non électriques; Procédés ou dispositifs permettant au patient d’obtenir une perception auditive par des sens physiologiques autres que l’ouïe; Dispositifs de protection pour les oreilles, portés sur le corps ou dans la main

Abrégé

Described herein are cell culture methods of producing hepatocytes, or mature, highly functional hepatocyte-like cells in vitro; cell culture media suitable for use in these methods; functional hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods; and cell compositions comprising hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains

Abrégé

A compressive/transform imager comprising a lens array positioned above input ports for collecting light into the input ports, waveguides routing the light from the input port to waveguide mixing regions (e.g. multi-mode interference couplers), and detectors for receiving outputs of the waveguide mixing regions.

Classes IPC  ?

• G01S 17/36 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées avec comparaison en phase entre le signal reçu et le signal transmis au même moment
• G02B 6/43 - Dispositions comprenant une série d'éléments opto-électroniques et d'interconnexions optiques associées
• H01Q 13/22 - Fente longitudinale dans la paroi limite du guide d'onde ou d'une ligne de transmission
• H01Q 15/04 - Dispositifs de réfraction ou diffraction, p.ex. lentille, prisme comportant un canal ou des canaux guide d'onde limités par des surfaces conductrices sensiblement perpendiculaires au vecteur champ électrique de l'onde, p.ex. lentille guide d'ondes à plaques parallèles
• H01Q 19/17 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p.ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des surfaces réfléchissantes où les surfaces sont concaves la source rayonnante primaire comprenant plusieurs éléments rayonnants
• H01Q 3/18 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne utilisant un mouvement mécanique relatif entre des éléments actifs primaires et des dispositifs secondaires des antennes ou systèmes d'antennes pour faire varier la position relative d'un élément primaire actif vis-à-vis d'un dispositif réfléchissant où l'élément primaire actif est mobile et l'élément réfléchissant est fixe
• H01Q 3/40 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante faisant varier la phase par des moyens électriques avec une matrice faisant varier l'angle de déphasage
• H01Q 3/44 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier les caractéristiques électriques ou magnétiques des dispositifs de réflexion, de réfraction ou de diffraction associés à l'élément rayonnant

Abrégé

Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.

Classes IPC  ?

• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

An oligonucleotide is prepared by the controlled, iterative addition of nucleotides to seed molecules at a functionalized electrode on a digital microfluidic device (DMF). Droplets containing a payload such as specific nucleotides and/or an enzyme, terminal deoxynucleotidyl transferase (TdT), for example, are individually guided, via path electrodes, to the functionalized electrodes, where chains are grown by addition of one nucleotide at a time. The DMF device includes an input section, containing reservoirs for reagents, a reaction section for growing the nucleotide chains and an output section for collecting waste and product. Each unit electrode on the device can be individually and independently addressed.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques

Abrégé

A system for management and control of vehicles is disclosed. In one example, the system manages and controls air traffic of aerial vehicles such as unmanned aerial vehicles (UAVs). The vehicular system includes vehicles including sensors for gathering sensor data, and a distributed control system that controls and manages the vehicles using the sensor data.

Classes IPC  ?

• B64C 39/02 - Aéronefs non prévus ailleurs caractérisés par un emploi spécial
• G05D 1/10 - Commande de la position ou du cap dans les trois dimensions simultanément
• G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p.ex. pilote automatique
• G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
• G08G 5/00 - Systèmes de commande du trafic aérien
• H04W 88/04 - Dispositifs terminaux adapté à la retransmission à destination ou en provenance d'un autre terminal ou utilisateur

Abrégé

A light steering system and method for diffractive steering of electromagnetic radiation such as visible light is disclosed. Embodiments of the light steering system include leaky-mode SAW modulators as light modulator devices. The SAW modulators preferably include reflective diffractive gratings. The gratings are mounted to/patterned upon an exit face that opposes an exit surface of the SAW modulator, in one example. Steering of light signals emitted from the SAW modulators in these systems can be accomplished by varying wavelength of light signals introduced to the SAW modulators, and/or by varying frequency of RF drive signals applied to the SAW modulators. In addition, light field generators that incorporate SAW modulators of the proposed light steering system within displays of the light field generators are also disclosed.

Classes IPC  ?

• G02F 1/11 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments acousto-optiques, p.ex. en utilisant la diffraction variable par des ondes sonores ou des vibrations mécaniques analogues
• G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c. à d. déflexion
• G02F 1/33 - Dispositifs de déflexion acousto-optique
• G02F 1/335 - Dispositifs de déflexion acousto-optique ayant une structure de guide d'ondes optique

Abrégé

Stimulus-controlled cell lysis compositions and methods of their use are described.

Classes IPC  ?

• C07K 14/435 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C12N 15/09 - Technologie d'ADN recombinant

Abrégé

A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.

Classes IPC  ?

• C12M 1/40 - Appareillage spécialement destiné à l'utilisation d'enzymes libres, immobilisées ou liées à un support, p.ex. appareils contenant un lit fluidisé d'enzymes immobilisées
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
• C12N 15/86 - Vecteurs viraux

Abrégé

A system is described for multi-frequency ultrasonically-encoded optical tomography of target tissue. A light source generates light input signals to the target tissue. An ultrasound transducer array has ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to an imaging volume within the target tissue. An optical sensor senses scattered light signals from the imaging volume, wherein the scattered light signals include light input signals modulated by acousto-optic interactions with the ultrasound input signals. Spectral analysis of the scattered light signals is performed to create a three-dimensional image map representing biomarker characteristics of the target tissue.

Classes IPC  ?

• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p.ex. DICOM, HL7 ou PACS

Abrégé

A system is described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. One or more sensors sense tomography output signals from the target probe volume, wherein the tomography output signals contain an interaction component generated by interaction of the probe input signals with the ultrasound input signals. A tomography analysis of the tomography output signals is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.

Classes IPC  ?

• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p.ex. DICOM, HL7 ou PACS

Abrégé

A system is described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. One or more sensors sense tomography output signals from the target probe volume, wherein the tomography output signals contain an interaction component generated by interaction of the probe input signals with the ultrasound input signals. A tomography analysis of the tomography output signals is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.

Classes IPC  ?

• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p.ex. DICOM, HL7 ou PACS

Abrégé

A system and corresponding method are described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. A photorefractive crystal mixes scattered light output signals from the target probe volume with an optical reference beam input to produce optical tomography output signals including ultrasound sum frequencies components. A photodetector senses the optical tomography output signals from the photorefractive crystal. A tomography analysis of the tomography output signals including the ultrasound sum frequencies components is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.

Classes IPC  ?

• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p.ex. DICOM, HL7 ou PACS

Abrégé

An apparatus includes a nanophotonic cavity, a waveguide, a microfluidic channel, and a photon detector. The cavity and the waveguide are fabricated out of a wide band gap semiconductor with an index of refraction that provides index contrast with the synthesis medium. One arrangement includes a photonic crystal having walls defining a channel for directing fluid flow. A functionalized spot is disposed in the channel for being tethered to a seed molecule to which a plurality of mers will be added. The walls extend downstream of the functionalized spot by a length that is at least as long as said molecule when assembled. The molecule can be linearized by a suitable fluid flow.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B82Y 20/00 - Nano-optique, p.ex. optique quantique ou cristaux photoniques
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/03 - Dispositions ou appareils pour faciliter la recherche optique - Détails de structure des cuvettes

Abrégé

Microfluidic devices and associated methods are disclosed. A microfluidic device includes a target entrainment channel and an effluent channel on opposing sides of a semipermeable membrane. A restrictor channel that is narrower than the effluent channel is interposed between the semipermeable membrane and the effluent channel. Fluid that flows from the target entrainment channel, through the semipermeable membrane and the restrictor channel to the effluent channel, pins target cells along the center of the target entrainment channel for electroporation using an electrode in the channel.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

e.ge.g., <10 cells/ ml) that are present within a complex biological sample.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

A distributed analytics system for identification and determination of disease and/or injuries is implemented on mobile computing devices carried by the users and a distributed computer network communicating with the mobile computing devices.

Classes IPC  ?

• G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
• G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux

Abrégé

A computer-implemented method is described for detecting, identifying and locating an object feature in a ferromagnetic object. At least one hardware processor executes program instructions to: define a planned scan trajectory for scanning the ferromagnetic object with a sensor array comprising a plurality of magnetometer sensors, measure magnetic fields of the ferromagnetic object with the sensor array along an actual scan trajectory at locations adjacent to the ferromagnetic material to produce object scanning data representing magnetic characteristics of the ferromagnetic object along the actual scan trajectory. The actual scan trajectory includes deviation motion of the scanning array from the planned scan trajectory. The deviation motion is then compensated for to identify and locate the object feature in the ferromagnetic object.

Classes IPC  ?

• G01N 27/85 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques pour rechercher la présence des criques en étudiant des champs magnétiques de dispersion en utilisant des méthodes magnétographiques

Abrégé

This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B33Y 10/00 - Procédés de fabrication additive
• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat

Abrégé

This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique

Abrégé

A multi-layered electronic device including two or more stacked metal conducting layers, a dielectric layer disposed between metal conducting layers, and at least one electrical connection extending between contact pads of metal conducting layers and through a through hole of the dielectric layer is provided. A system including at least one multi-layered electronic device, a satellite coupled to at least one multi-layered electronic device, and a controller hub electrically connected to the multi-layered electronic device via the satellite is also provided. A method of manufacturing the multi-layered electronic device including forming first and second first metal conducting layers, depositing a dielectric layer adjacent to the metal conducting layers, and connecting the metal conducting layers is also provided.

Classes IPC  ?

• H05K 1/03 - Emploi de matériaux pour réaliser le substrat
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque

Abrégé

Improvements to atom interferometers. An improved atom interferometer has a single polarization-preserving fiber, coupled for propagation of beams of two Raman frequencies, and a parallel displacement beamsplitter for separating the laser beams into respective free-space-propagating parallel beams traversing at least one ensemble of atoms. A reflector generates one or more beams counterpropagating through the ensemble of atoms. Other improvements include interposing a beam-splitting surface common to a plurality of parallel pairs of beams counterpropagating through the ensemble of atoms, generating interference fringes between reflections of the beams to generate a detector signal; and processing the detector signal to derive at least one of relative phase and relative alignment between respective pairs of the counterpropagating beams.

Classes IPC  ?

• G01B 11/27 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour tester l'alignement des axes pour tester l'alignement des axes
• G01C 19/58 - Dispositifs sensibles à la rotation sans masse en mouvement
• G01P 15/08 - Mesure de l'accélération; Mesure de la décélération; Mesure des chocs, c. à d. d'une variation brusque de l'accélération en ayant recours aux forces d'inertie avec conversion en valeurs électriques ou magnétiques

Abrégé

A wire includes an elongate conductive core wire, an elongate insulating layer disposed on and surrounding the elongate conductive core wire, an elongate conductive shield wire disposed adjacent to the insulating layer and the elongate conductive core wire, an elongate conductive shield layer disposed on the insulating layer and on the conductive shield wire such that the elongate insulating layer, the elongate conductive core wire, and the elongate conductive shield wire are embedded in the elongate conductive shield layer, the elongate conductive shield wire being electrically connected to the elongate conductive shield layer.

Classes IPC  ?

• H01L 23/34 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température
• H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
• H01B 11/10 - Ecrans particuliers pour réduire les perturbations provoquées par des sources extérieures
• H01B 11/18 - Câbles coaxiaux; Câbles analogues ayant plusieurs conducteurs intérieurs dans un conducteur extérieur commun
• H01B 13/24 - Gainage; Blindage; Ecrans; Application de couches de protection d'un autre genre par extrusion
• H01L 23/552 - Protection contre les radiations, p.ex. la lumière
• H01B 11/06 - Câbles à paires ou quartes torsadées pourvus de moyens propres à réduire les effets de perturbations électromagnétiques ou électrostatiques, p.ex. écrans

Abrégé

Disclosed are systems, devices, apparatus, tools, coaxial cables, materials, methods, and other implementations that include a method comprising controllably stripping, through one or more applications of energy directed at a micro coaxial cable, a conductive shield layer of the micro coaxial cable to expose a portion of a core conductive wire of the micro coaxial wire, and controllably deforming the exposed portion of the core conductive wire of the micro coaxial wire through the one or more applications of energy.

Classes IPC  ?

• H02G 1/12 - Méthodes ou appareils spécialement adaptés à l'installation, entretien, réparation, ou démontage des câbles ou lignes électriques pour supprimer l'isolant ou l'armature des câbles, p.ex. de leur extrémité
• H01L 23/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
• H01R 43/28 - Appareils ou procédés spécialement adaptés à la fabrication, l'assemblage, l'entretien ou la réparation de connecteurs de lignes ou de collecteurs de courant ou pour relier les conducteurs électriques pour traiter le fil avant sa connexion aux pièces de contact, non prévus dans les groupes

Abrégé

viavia semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.

Classes IPC  ?

• C12N 7/02 - Isolement ou purification
• C12N 15/66 - Méthodes générales pour insérer un gène dans un vecteur pour former un vecteur recombinant, utilisant le clivage et la ligature; Utilisation de linkers non fonctionnels ou d'adaptateurs, p.ex. linkers contenant la séquence pour une endonucléase de restriction

Abrégé

According to various aspects and embodiments, a growth adaptive expandable stent is provided. The expandable stent includes a stent structure having a cylindrical shape that is self- expanding in a radial direction and includes a plurality of cylindrical rings disposed along a longitudinal axis of the stent structure. The stent structure is configured to exert a continuous outward radial force over time when implanted such that a diameter of the stent structure expands from a first value to a second value that is at least about 1.5 times the first value.

Classes IPC  ?

• A61F 2/24 - Valvules de cœur
• A61F 2/915 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles fabriquée à partir de feuilles perforées ou de tubes perforés, p.ex. perforés par découpe au laser ou gravés avec des bandes présentant une structure en méandre, des bandes adjacentes étant reliées l’une à l’autre

Abrégé

The present disclosure provides compositions including recombinant KIE bacteriophages, methods for making the same, and uses thereof. The recombinant KIE bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs

Abrégé

A bandpass optical filter comprises a broadband optical diffuser and a narrowband anti-diffuser disposed in a common optical path with the broadband optical diffuser.

Classes IPC  ?

• H04N 13/254 - Générateurs de signaux d’images utilisant des caméras à images stéréoscopiques en combinaison avec des sources de rayonnement électromagnétique pour l’éclairage du sujet

Abrégé

A navigation system that utilizes a discrete-time nonlinear filter to obtain a navigation solution using GPS signals and optional aiding sensor data is described. A nonlinear filter offers improved accuracy over linearized filters at low signal to noise ratios. A discrete-time nonlinear filter guarantees positive-definite calculated covariance matrices under all conditions without requiring any compensation or added parameters. The navigation system receives a modernized global navigation satellite system (GNSS) signal and correlates a digitized copy of the GNSS signal to generate ranging code measurements. A conditional probability density function for the code measurements is determined and used to calculate arbitrary moments of code delay and other expected values. The code measurements and the conditional probability density function are processed in a nonlinear tracking filter to generate recursive navigation state updates, which can be used by an output device, such as a display, to present navigation and tracking information.

Classes IPC  ?

• G01S 19/30 - Acquisition ou poursuite des signaux émis par le système lié au code

Abrégé

A star tracker includes a lens slice, a pixelated image sensor, an ephemeral database and a processor configured to estimate attitude, orientation and/or location of the star tracker based on an image of one or more celestial objects projected by the lens slice onto the pixelated image sensor. The lens slice is smaller and lighter than an optically comparable conventional lens, thereby making the star tracker less voluminous and less massive than conventional star trackers. A lens slice is elongated along one axis. Optical performance along the elongation axis is comparable to that of a conventional circular lens of equal diameter. Although optical performance along a width axis, perpendicular to the elongation axis, of a lens slice can be significantly worse than that of a conventional lens, use of two orthogonal lens slices provides adequate optical performance in both axes, and still saves volume and mass over a conventional lens.

Classes IPC  ?

• G01S 3/786 - Systèmes pour déterminer une direction ou une déviation par rapport à une direction prédéterminée utilisant le réglage d'une orientation des caractéristiques de directivité d'un détecteur ou d'un système de détecteurs afin d'obtenir une valeur désirée du signal provenant de ce détecteur ou de ce système de détecteurs la valeur désirée étant maintenue automatiquement
• G01S 3/781 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes électromagnétiques autres que les ondes radio - Détails
• G02B 3/06 - Lentilles simples ou composées à surfaces non sphériques à surfaces cylindriques ou en forme de tore

Abrégé

Acousto-optical modulators, such as a SAW modulators, with telescope arrays and superimposed volume gratings for light field generation are disclosed. These devices can employ pixelated demagnification and have layers of output optics, such as reflective gratings and/or arrays of transmissive refractive or diffractive lenses that manipulate the light emitted by the SAW modulator. In other cases, superimposed volume gratings are used, in which pixilation occurs in angle space.

Classes IPC  ?

• G02F 1/335 - Dispositifs de déflexion acousto-optique ayant une structure de guide d'ondes optique
• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

A well telemetry system supplies power to downhole sensor nodes (60) employed for obtaining telemetry data in oil wells. The nodes are held in the cement that lines the well and surround the casing (20). At the surface, an AC power unit (1510) is connected to the casing 2(0) and geological structure (50) that surrounds the cement (55). Power to nodes is supplied using an AC resonant circuit that generates standing waves of electrical power on the casing. Power from the standing waves is delivered to the nodes (60-1, 60-02) which are located at antinodes of the standing wave. The nodes are held in cement that surround the casing, with one of their two electrodes (65, 70) connected to the casing and the other connected to the cement or to geological structure.

Classes IPC  ?

• E21B 47/12 - Moyens pour la transmission de signaux de mesure ou signaux de commande du puits vers la surface, ou de la surface vers le puits, p.ex. pour la diagraphie pendant le forage

Abrégé

A system and method for light field generation is disclosed. A proposed holographic display system encodes views of a scene into surface acoustic waves (SAW signals) that propagate along waveguides of SAW modulators and/or optical signals propagating in the waveguides. Each view provides a different perspective of the scene when the views are projected as light fields out of the SAW modulators and are viewed at different locations by an observer. In some examples, the system encodes the brightness information for each view into the light signals.

Classes IPC  ?

• G03H 1/22 - Procédés ou appareils pour obtenir une image optique à partir d'un hologramme

Abrégé

A parallelized chain-synthesizing technique includes an array of wells, each well in the array providing a location where a specific arbitrary sequence for polymeric chains can be grown. An optical addressing system selectively delivers light to the wells to mediate or control reactions in the wells.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés

Abrégé

A method is described for determining roll rate for a spin-stabilized projectile. A yaw signal and a pitch signal are measured for the projectile, wherein: (i) for a trajectory path being travelled by the projectile over the Earth's surface, projectile stability is created by spinning of the projectile about a longitudinal spin axis oriented tangent to the projectile trajectory, (ii) the yaw signal represents yaw motion of the projectile about a yaw axis oriented along a line through the Earth's center and orthogonal to the spin axis, and (iii) the pitch signal represents pitch motion of the projectile about a pitch axis orthogonal to the spin axis and the yaw axis, and wherein the yaw signal and the pitch signal are modulated by spin rate of the projectile spinning about the spin axis. A roll rate signal is extracted from one of the yaw signal and the pitch signal.

Classes IPC  ?

• G01C 21/10 - Navigation; Instruments de navigation non prévus dans les groupes en utilisant des mesures de la vitesse ou de l'accélération
• F41G 7/30 - Systèmes de guidage à liaison de commande

Abrégé

A method and system of delivering a charged cargo, such as a biomolecule, to a target structure, such as cells, exosomes, other vesicles or micelles, using an electroactive porous membrane. This method comprises contacting an electroactive porous membrane with a fluid flow toward the membrane. The fluid contains charged biomolecules and the membrane and biomolecules are oppositely charged so that the biomolecules in the fluid are trapped on the membrane as the fluid flows through the pores of the membrane. Acceptor cells of interest are pinned to the membrane by the flow of the fluid, thereby aggregating the cells onto the membrane in close proximity to the trapped biomolecules. Finally, the acceptor cells are permeabilized.

Classes IPC  ?

• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation
• C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p.ex. par magnétisme, par des ondes sonores