Abrégé

A PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch-L2-A2 (I) wherein: Ch is a chelator, L1 and L2, identical or different, are a linker whereas A1 and A2, identical or different, are a urea-based PSMA ligand.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a method for opening and discharging an electrochemical generator (10) comprising a negative electrode containing lithium or sodium and a positive electrode optionally containing lithium or sodium, the method comprising the following successive steps: - opening the electrochemical generator (10) in a cutting zone, with a cutting element (20), preferably having an electrical resistance greater than 100 mΩ, the electrochemical generator being opened while spraying the cutting zone with a first solution (100), - discharging the electrochemical generator by partially or completely submerging the electrochemical generator (10) in a second solution (200).

Classes IPC  ?

• B09B 3/35 - Déchiquetage, écrasement ou découpage
• H01M 10/44 - Méthodes pour charger ou décharger
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
• H01M 4/1395 - Procédés de fabrication d’électrodes à base de métaux, de Si ou d'alliages
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
• H01M 10/0569 - Matériaux liquides caracterisés par les solvants
• B09B 101/16 - Piles ou batteries

Abrégé

The invention relates to a device (10) comprising: - a component (20) configured to contain or circulate a solution, the component (20) having a wall (21) made of steel or a nickel-based alloy comprising chromium, - a solution (30), in contact with the wall (21), comprising a mixture of molten chloride salts, the solution also comprising Ti2+ions and Ti3+ions, the Ti3+/Ti2+ ratio being between 20/80 and 70/30.

Classes IPC  ?

• C23F 11/18 - Inhibition de la corrosion de matériaux métalliques par application d'inhibiteurs sur la surface menacée par la corrosion ou par addition d'inhibiteurs à l'agent corrosif dans d'autres liquides au moyen d'inhibiteurs inorganiques
• C23F 13/00 - Moyens pour empêcher la corrosion des métaux par protection anodique ou cathodique
• F24S 20/20 - Collecteurs de chaleur solaire pour recevoir de l’énergie solaire concentrée, p.ex. récepteurs pour centrales électriques solaires
• F24S 80/20 - Fluides vecteur spécialement adaptés pour les collecteurs de chaleur solaire
• G21C 1/03 - Réacteurs de fission rapides, c. à d. réacteurs n'utilisant pas de modérateur refroidis par un réfrigérant non nécessairement pressurisé, p.ex. réacteurs du type piscine
• G21C 3/54 - Sels fondus, compositions oxydes ou hydroxydes
• G21C 17/022 - Dispositifs ou dispositions pour la surveillance du réfrigérant ou du modérateur pour la surveillance de réfrigérants ou de modérateurs liquides
• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
• G01N 17/02 - Systèmes de mesure électro-chimique de l'action due aux intempéries, de la corrosion ou de la protection contre la corrosion
• G01N 27/30 - Composants de cellules électrolytiques Électrodes, p.ex. électrodes pour tests; Demi-cellules
• G01N 27/416 - Systèmes
• C23F 15/00 - Autres méthodes pour prévenir la corrosion, l'entartrage ou les incrustations
• C25C 3/28 - Production, récupération ou affinage électrolytique de métaux par électrolyse de bains fondus du titane, du zirconium, de l'hafnium, du tantale ou du vanadium du titane
• C09K 5/02 - Substances qui subissent un changement d'état physique lors de leur utilisation
• C09K 5/12 - Substances fondues, c.à d. substances solides à température ambiante, p.ex. métaux ou sels

Abrégé

A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) so prepared are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs

Abrégé

A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, to fix the radioisotope on the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium, the method comprising at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising a citric acid salt as an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises citrate complexes of the radioisotope is obtained; b) dissociating the citrate complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) washing at least one the second stationary phase with an aqueous solution A4.

Classes IPC  ?

• B01D 15/18 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
• B01D 15/38 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p.ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale

Abrégé

A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: where the dotted line represents the covalent bond to the linker; the linker is of formula: -β-Ala-β-Ala-; and the Gastrin-releasing peptide receptor antagonist has the amino acid sequence: -DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a process for purifying ruthenium from an aqueous nitric acid solution in which same is present together with technetium and metal impurities, at a concentration at least 10 times lower than that of the technetium. It also relates to a process for producing ruthenium-97 from a technetium-99 target which has been been proton-irradiated beforehand, which process comprises the implementation of the purification process. Application: production of ruthenium-97-based radiopharmaceuticals used in nuclear medicine for the diagnosis of cancer by imaging and the treatment thereof by targeted radiotherapy.

Classes IPC  ?

• C01G 55/00 - Composés du ruthénium, du rhodium, du palladium, de l'osmium, de l'iridium, ou du platine

Abrégé

The invention relates to a method for producing hydrogen by electrochemically reforming an alcohol. This method comprises electrolyzing alcohol in an electrolytic cell comprising an anode, an electrolyte and a cathode, and is characterized in that at least part of the outer surface of the anode comprises one or more radioactive platinoids selected from among palladium, ruthenium and rhodium, these one or more radioactive platinoids being derived from an acidic aqueous solution containing fission products from a spent nuclear fuel.

Classes IPC  ?

• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• B01J 23/40 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe des métaux nobles des métaux du groupe du platine
• C25B 3/07 - Composés contenant au moins un atome d’oxygène
• C25B 3/23 - Oxydation
• C25B 11/052 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par le matériau Électrodes comportant des électro-catalyseurs sur un substrat ou un support Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
• B01J 37/34 - Irradiation ou application d'énergie électrique, magnétique ou ondulatoire, p.ex. d'ondes ultrasonores
• C25B 11/061 - Métal ou alliage
• C25B 11/065 - Carbone
• C25B 11/081 - Métal noble
• C25B 11/097 - Plusieurs métaux nobles ou alliages de métaux nobles
• C25D 3/50 - Dépôt électrochimique; Bains utilisés à partir de solutions de métaux du groupe du platine
• C25D 7/06 - Fils; Bandes; Feuilles
• G21C 19/46 - Procédés aqueux

Abrégé

A method for opening an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30) optionally containing lithium or sodium, the method comprising the following successive steps: a) immersing the electrochemical generator (10) in a solution comprising an inert liquid and, optionally, a redox species, referred to as an oxidising redox species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; b) opening the electrochemical generator in the solution with a cutting element (100) that has an electrical resistance between 1 mΩ and 1 kΩ, and preferably between 5 mΩ and 100 Ω.

Classes IPC  ?

• H01M 6/52 - Récupération des parties utiles des éléments ou batteries usagés
• H01M 8/008 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Élimination ou recyclage des éléments à combustible
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

A method for opening an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30) optionally containing lithium or sodium, the method comprising the following successive steps: a) immersing the electrochemical generator (10) in a solution comprising an inert liquid and, optionally, a redox species, referred to as an oxidising redox species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; b) opening the electrochemical generator in the solution with a cutting element (100) that has an electrical resistance between 1 m? and 1 k?, and preferably between 5 m? and 100 ?.

Classes IPC  ?

• H01M 6/52 - Récupération des parties utiles des éléments ou batteries usagés
• H01M 8/008 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Élimination ou recyclage des éléments à combustible

Abrégé

A process is for preparing a site-specific bioconjugated antibody of a formula (I): Ab-(Linker-Chelator)n (I). The Linker is an oligopeptide with an N-terminal end. The Chelator is a metal chelating agent. n is a Chelator-to antibody ratio (CAR), wherein 0

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulines; Leurs fragments
• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p.ex. séquences de liaison peptidiques vulnérable aux protéases

Abrégé

The invention relates to a method for dissolving a positive electrode material of a battery comprising a step during which the positive electrode material, comprising lithium and optionally cobalt and/or nickel, is submerged in an acid solution having a pH between 0 and 4, the acid solution containing either manganese ions or hydrogen peroxide, by means of which the lithium and optionally the cobalt and/or nickel is dissolved, and the manganese ions are selectively precipitated in the form of manganese oxyhydroxide.

Classes IPC  ?

• C22B 3/08 - Acide sulfurique
• C22B 3/44 - Traitement ou purification de solutions, p.ex. de solutions obtenues par lixiviation par des procédés chimiques
• C22B 26/12 - Obtention du lithium

Abrégé

The invention relates to a method for dissolving a positive electrode material of a battery comprising a step during which the positive electrode material, comprising lithium and optionally cobalt and/or nickel, is submerged in an acid solution having a pH between 0 and 4, the acid solution containing either manganese ions or hydrogen peroxide, by means of which the lithium and optionally the cobalt and/or nickel is dissolved, and the manganese ions are selectively precipitated in the form of manganese oxyhydroxide.

Classes IPC  ?

• C22B 3/08 - Acide sulfurique
• C22B 3/44 - Traitement ou purification de solutions, p.ex. de solutions obtenues par lixiviation par des procédés chimiques
• C22B 3/00 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés
• C22B 26/12 - Obtention du lithium
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

The invention relates to a PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch -L2-A2 (I) wherein: Ch is a chelator, L1 and L2, identical or different, are a linker whereas A1 and A2, identical or different, are an urea-based PSMA ligand. The invention also relates to the uses thereof.

Classes IPC  ?

• A61K 51/04 - Composés organiques

Abrégé

The invention relates to a PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch -L2-A2(I) wherein: Ch is a chelator, L1and L2, identical or different, are a linker whereas A1and A2, identical or different, are an urea-based PSMA ligand. The invention also relates to the uses thereof.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• A61P 35/00 - Agents anticancéreux
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques

Abrégé

The invention relates to a method for securing an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising the following successive steps: (a)immersing an electrochemical generator (10) in an ionic liquid solution (100) containing a solvent ionic liquid and, optionally, a redox species, referred to as the oxidising species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; (b) opening the electrochemical generator with an electrically insulative element, opening being performed in the ionic liquid solution.

Classes IPC  ?

• B09B 3/00 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p.ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/40 - Alliages à base de métaux alcalins
• H01M 6/52 - Récupération des parties utiles des éléments ou batteries usagés
• H01M 10/44 - Méthodes pour charger ou décharger
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

The invention relates to a method for securing an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising the following successive steps: (a) immersing an electrochemical generator (10) in an ionic liquid solution (100) containing a solvent ionic liquid and, optionally, a redox species, referred to as the oxidising species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; (b) opening the electrochemical generator with an electrically insulative element, opening being performed in the ionic liquid solution.

Classes IPC  ?

• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
• H01M 6/52 - Récupération des parties utiles des éléments ou batteries usagés
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/40 - Alliages à base de métaux alcalins
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p.ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• B09B 3/00 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif
• H01M 10/44 - Méthodes pour charger ou décharger
• H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif

Abrégé

Disclosed is a method for discharging an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising a discharging step during which the electrochemical generator (10) is brought into contact with an ionic liquid solution (100) containing a solvent ionic liquid and an electrically conductive powder so as to discharge the electrochemical generator (10).

Classes IPC  ?

• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
• H01M 6/52 - Récupération des parties utiles des éléments ou batteries usagés
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/40 - Alliages à base de métaux alcalins
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
• H01M 10/44 - Méthodes pour charger ou décharger
• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p.ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• B09B 3/00 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif
• H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif

Abrégé

22. The invention also relates to the uses of the conjugate or salt thereof.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, characterized in that: - the chelator is of formula (I): where the dotted line represents the covalent bond to the linker; - the linker is of formula: -?-Ala-?-Ala-; and - the Gastrin-releasing peptide receptor antagonist has the amino acid sequence: -DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2. The invention also relates to the uses of the conjugate or salt thereof.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines

Abrégé

A method for producing lead-212 of very high radiological purity from an aqueous solution comprising thorium-228 and daughters thereof. Manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• B01D 15/18 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
• B01D 15/16 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
• B01D 15/26 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation

Abrégé

A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Classes IPC  ?

• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales
• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• B01D 15/18 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement

Abrégé

A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, to fix the radioisotope on the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium, the method comprising at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises complexes of the radioisotope is obtained; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) washing at least one the second stationary phase with an aqueous solution A4.

Classes IPC  ?

• G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
• G01N 30/18 - Injection utilisant un septum ou une microseringue

Abrégé

The invention relates to a diaza-18-crown-6 derivative having formula (I): wherein: B is a moiety for a covalent bonding reaction; the two A are identical to each other and are a group of formula (II): where: n = 0 to 4; X1, X2, X3, X4and X5are N, a -CH group or a -CR group wherein R is a -P(O)(OR1)(OR2), -P(O)R1(OR2), -P(O)R1R2, -P(S)(SR1)(SR2), -P(S)R1(SR2) or -P(S)R1R2group in which R1and R2144 alkyl group, provided that no more than two of X1, X2, X3, X4and X5are N and no more than one of X1, X2, X3, X4and X5 is a -CR group. The invention also relates to a conjugate comprising the diaza-18-crown-6 derivative covalently bonded to a targeting moiety for biological cells, a chelate comprising radium chelated by the conjugate, and to uses of the diaza-18-crown-6 derivative, the conjugate and the chelate.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• C07D 273/08 - Composés hétérocycliques contenant des cycles comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle, non prévus par les groupes comportant deux atomes d'azote et plusieurs atomes d'oxygène
• C07F 3/00 - Composés contenant des éléments des groupes 2 ou 12 de la classification périodique
• C07F 9/38 - Acides phosphoniques (R—P(:O)(OH)2); Acides thiophosphoniques

Abrégé

Disclosed is a method for selectively separating a carbon-containing material from a mixture comprising a positive electrode and a negative electrode originating from fuel cells and/or electrochemical batteries, the method comprising the following successive steps: a) providing a mixture comprising a positive electrode and a negative electrode, each electrode comprising a current collector, an active material and a binder, the active material of the negative electrode being a carbon-containing material, preferably graphite, b) bringing the mixture comprising the positive electrode and the negative electrode into contact with a separating solution, in the presence of ultrasound, the separating solution comprising a solvent and possibly additives, until the carbon-containing material is selectively separated from the current collector of the negative electrode, the active material of the positive electrode remaining joined to the current collector of the positive electrode.

Classes IPC  ?

• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

Disclosed is a method for selectively separating a carbon-containing material from a mixture comprising a positive electrode and a negative electrode originating from fuel cells and/or electrochemical batteries, the method comprising the following successive steps: a) providing a mixture comprising a positive electrode and a negative electrode, each electrode comprising a current collector, an active material and a binder, the active material of the negative electrode being a carbon-containing material, preferably graphite, b) bringing the mixture comprising the positive electrode and the negative electrode into contact with a separating solution, in the presence of ultrasound, the separating solution comprising a solvent and possibly additives, until the carbon-containing material is selectively separated from the current collector of the negative electrode, the active material of the positive electrode remaining joined to the current collector of the positive electrode.

Classes IPC  ?

• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

Disclosed is a method for recycling at least one electrode, comprising the following consecutive steps: a) providing at least one electrode comprising a current collector, an active material and, optionally, a binder, b) immersing the at least one electrode in an ionic liquid solution comprising a solvent ionic liquid, in the presence of ultrasound, whereby the active material, and if applicable the binder, is separated from the current collector.

Classes IPC  ?

• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium

Abrégé

Disclosed is a method for recycling at least one electrode, comprising the following consecutive steps: a) providing at least one electrode comprising a current collector, an active material and, optionally, a binder, b) immersing the at least one electrode in an ionic liquid solution comprising a solvent ionic liquid, in the presence of ultrasound, whereby the active material, and if applicable the binder, is separated from the current collector.

Classes IPC  ?

• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

The present application concerns a process for preparing a site-specific bioconjugated antibody with a metal Chelator, the bionconjugated antibody and its use in nuclear medicine.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulines; Leurs fragments

Abrégé

The present application concerns a process for preparing a site-specific bioconjugated antibody with a metal Chelator, the bionconjugated antibody and its use in nuclear medicine.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulines; Leurs fragments
• A61P 35/00 - Agents anticancéreux

Produits et services

Pharmaceuticals or radiopharmaceuticals, and their components, for medical diagnostic, in particular for locating cancerous tumours; Diagnostic preparations for medical purposes, in particular for locating cancerous tumours Metal tanks and containers for the packaging, transport, storage, and warehousing of radioactive products, radiopharmaceuticals, radiopharmaceutical constituents Industrial radionuclide generators and robots for manufacturing and preparing radiopharmaceuticals Medical apparatus and devices for use in the diagnosis and localization of cancerous tumors and other diseases in the human body, and in the treatment of cancer or viral diseases Research and development, analysis, studies and design relating to pharmaceuticals, radiopharmaceuticals and pharmaceutical and radiopharmaceutical constituents, all for the treatment of diseases and in particular of cancers

Abrégé

An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• B01D 15/20 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement de la matière adsorbante ou absorbante
• B01D 15/36 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p.ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
• B01D 15/42 - Adsorption sélective, p.ex. chromatographie caractérisée par le mode de développement, p.ex. par déplacement ou par élution
• C22B 60/02 - Obtention du thorium, de l'uranium ou des autres actinides
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales

Abrégé

The invention relates to a method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• B01D 15/08 - Adsorption sélective, p.ex. chromatographie
• C01F 13/00 - Composés du radium
• C01F 15/00 - Composés du thorium

Abrégé

The invention relates to a method for transferring a radioisotope that is attached to a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, in order to fix the radioisotope to the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium. Said method comprises at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 is obtained which comprises complexes of the radioisotope; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) carrying out at least one washing of the second stationary phase with an aqueous solution A4.

Classes IPC  ?

• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• G21G 4/00 - Sources radioactives
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales

Abrégé

The invention relates to a method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• C01F 15/00 - Composés du thorium
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales
• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs

Abrégé

The invention relates to a method for transferring a radioisotope that is attached to a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, in order to fix the radioisotope to the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium. Said method comprises at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 is obtained which comprises complexes of the radioisotope; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) carrying out at least one washing of the second stationary phase with an aqueous solution A4.

Classes IPC  ?

• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
• G21G 4/00 - Sources radioactives
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs

Abrégé

The invention relates to a method for producing x-ray very high purity lead-212 from an aqueous solution comprising thorium-228 and its descendants. Applications: manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• C22B 13/06 - Affinage

Abrégé

The invention relates to a method for producing x-ray very high purity lead-212 from an aqueous solution comprising thorium-228 and its descendants. Applications: manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

Classes IPC  ?

• C22B 3/24 - Traitement ou purification de solutions, p.ex. de solutions obtenues par lixiviation par des procédés physiques, p.ex. par filtration, par des moyens magnétiques par adsorption sur des substances solides, p.ex. par extraction avec des résines solides
• B01D 15/30 - Chromatographie de partage
• C22B 13/00 - Obtention du plomb
• C22B 60/00 - Obtention des métaux ayant un nombre atomique de 87 ou plus, c. à d. métaux radioactifs
• C22B 60/02 - Obtention du thorium, de l'uranium ou des autres actinides

Abrégé

A cancer targeting composition, kit, and method for treatment of cancer cells overexpressing somatostatin receptors is disclosed. The composition includes a radioisotope, a chelator, and a targeting moiety. The chelator includes a nitrogen ring structure including a tetraazacyclododecane, a triazacyclononane, and/or a tetraazabicyclo [6.6.2] hexadecane derivative. The targeting moiety includes a somatostatin receptor targeting peptide. The somatostatin receptor targeting peptide includes an octreotide derivative. The targeting moiety is chelated to the radioisotope by the chelator whereby the cancer cells are targeted for elimination.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines
• A61P 35/00 - Agents anticancéreux
• A61K 51/04 - Composés organiques
• A61K 47/10 - Alcools; Phénols; Leurs sels, p.ex. glycérol; Polyéthylène glycols [PEG]; Poloxamères; Alkyléthers de PEG/POE
• A61K 47/12 - Acides carboxyliques; Leurs sels ou anhydrides
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/22 - Composés hétérocycliques, p.ex. acide ascorbique, tocophérol ou pyrrolidones
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 

Abrégé

A process for producing a daughter radionuclide from a parent radionuclide includes a) loading the parent radionuclide on a first solid medium contained in a generator and onto which the parent radionuclide is retained and whereby the daughter radionuclide is formed by radioactive decay of the parent radionuclide; b) eluting this medium with a A0 solution so as to recover a A1 solution comprising the daughter radionuclide; c) optionally adjusting the pH of the A1 solution so as to obtain a A1′ solution, d) loading this A1 or A1′ solution onto the head of a second solid medium contained in a chromatography column; e) first washing said second solid medium with a A2 solution; f) second washing said second solid medium with a A2′ solution; g) eluting the daughter radionuclide with a A3 solution. The first washing step is conducted from head to tail of the column and the second washing step and the second eluting step are conducted from tail to head of the column.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• B01D 15/20 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement de la matière adsorbante ou absorbante
• B01D 15/36 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p.ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
• B01D 15/42 - Adsorption sélective, p.ex. chromatographie caractérisée par le mode de développement, p.ex. par déplacement ou par élution
• C22B 60/02 - Obtention du thorium, de l'uranium ou des autres actinides
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales

Abrégé

The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• G01N 30/84 - Préparation des fractions à séparer
• G01D 15/12 - Eléments enregistreurs magnétiques
• G01N 30/06 - Préparation
• B01D 15/42 - Adsorption sélective, p.ex. chromatographie caractérisée par le mode de développement, p.ex. par déplacement ou par élution
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p.ex. émulsion, microcapsules, liposomes
• C22B 13/02 - Obtention du plomb par voie sèche
• C22B 13/06 - Affinage
• C22C 11/00 - Alliages à base de plomb
• B01D 15/12 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la préparation de l'alimentation
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales

Abrégé

A cancer targeting composition, kit, and method for treatment of cancer cells overexpressing somatostatin receptors is disclosed. The composition includes a radioisotope, a chelator, and a targeting moiety. The chelator includes a nitrogen ring structure including a tetraazacyclododecane, a triazacyclononane, and/or a tetraazabicyclo [6.6.2] hexadecane derivative. The targeting moiety includes a somatostatin receptor targeting peptide. The somatostatin receptor targeting peptide includes an octreotide derivative. The targeting moiety is chelated to the radioisotope by the chelator whereby the cancer cells are targeted for elimination.

Classes IPC  ?

• A61K 51/08 - Peptides, p.ex. protéines
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention concerns a process for producing a daughter radionuclide from a parent radionuclide comprising the purification of the daughter radionuclide on a chromatography column, as well as the apparatus for carrying out such process.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs

Abrégé

The present invention concerns a process for producing a daughter radionuclide from a parent radionuclide comprising the purification of the daughter radionuclide on a chromatography column, as well as the apparatus for carrying out such process.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs

Abrégé

The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterized in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.

Classes IPC  ?

• G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p.ex. production d'isotopes radioactifs
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p.ex. émulsion, microcapsules, liposomes
• C22B 13/02 - Obtention du plomb par voie sèche
• C22B 13/06 - Affinage
• C22C 11/00 - Alliages à base de plomb
• G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales