A breath capture and analysis system includes a breath inlet for capturing a user's breath. The breath is drawn into the system and retained for analysis. The system includes a membrane that allows volatile organic compounds contained in the breath to pass therethrough. The volatile organic compounds pass into a vacuum chamber that includes a residual gas analyzer that is configured to analyze the volatile organic compounds. The analyzed breath is then vacated from the system.
A catheter control system may include a containment structure, a sensor coupled to the containment structure, and a plurality of actuators coupled to the containment structure. The containment structure may define a lumen configured to allow a fluid to flow therethrough, and a plurality of openings in fluid communication with the lumen. The sensor may be configured to detect a current position and/or orientation of the containment structure. Each of the actuators may be associated with at least one respective opening of the plurality of openings and configured to regulate fluid flow through the at least one respective opening.
In an embodiment, the present disclosure pertains to an electrode having a first layer and a second layer. In some embodiments, the first layer includes a conductive polymer. In some embodiments, the second layer is positioned above the first layer. In some embodiments, the second layer includes an inorganic material that forms a conductive network on the first layer. In an additional embodiment, the present disclosure pertains to a method of making an electrode. In general, the method providing a mold with a desired indented pattern, pouring a solution including a conductive polymer into the indented pattern to form a first layer, and pouring a solution including an inorganic material onto the first layer to form a second layer. In some embodiments, the inorganic material forms a conductive network on the first layer.
A61B 5/268 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p.ex. des polymères PEDOT:PSS
A61B 5/257 - Moyens adhésifs, p.ex. garnitures ou bandes adhésives
A composite rotor for an electric motor includes an annular composite support plate extending radially relative a central axis of the composite rotor between an inner diameter defining a central opening of the composite support plate and an outer diameter, wherein the composite support plate includes a quasi-isotropic composite material, and an annular magnet assembly extending around the central axis of the composite rotor and coupled to a surface of the composite support plate.
H02K 1/18 - Moyens de montage ou de fixation des parties magnétiques fixes sur ou aux structures constituant le stator
H02K 1/2795 - Rotors faisant face axialement à des stators le rotor étant formé de plusieurs aimants disposés sur la circonférence
H02K 21/24 - Moteurs synchrones à aimants permanents; Génératrices synchrones à aimants permanents avec des induits fixes et des aimants tournants avec des aimants disposés axialement en face des induits, p.ex. dynamos de bicyclette du type moyeu
5.
VASCULAR PROSTHESIS FOR LEAK PREVENTION DURING ENDOVASCULAR ANEURYSM REPAIR
An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61F 2/945 - Stents conservant leur forme, c. à d. non déformables, après mise en place à l’endroit voulu durcissables, p.ex. stents formés in situ
A61F 2/954 - Instruments spécialement adaptés pour insérer ou retirer les stents ou les endoprothèses déployables couvertes pour insérer les stents ou les endoprothèses déployables couvertes dans une bifurcation
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/18 - Matériaux au moins partiellement opaques aux rayons X ou au laser
6.
RAPID ELICITATION OF BROADLY NEUTRALIZING BOVINE ANTIBODIES TO HIV ENV
The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab′)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.
Synthetic compositions comprising a plant element and at least one fungal endophyte are described. The fungal endophyte is capable of improving plant tolerance to biotic stress as compared to a reference plant element not further comprising the endophyte. Examples of biotic stress include the biotic stress caused by a nematode, an aphid, a fleahopper, a Lygus bug, a stink bug, a soy looper, a cabbage looper, or a fungus.
Provided here are neural network-based methods and systems that process nucleic acid sequences to identify, characterize, and interpret specific properties, like characterization of promoters of gene sequences, identification of viral genomes, and stability of the nucleic acids. The neural network models can be trained in supervised, unsupervised, and semi-supervised environments.
A flexible electrode includes a layer of an interpenetrating network of silver nanowires and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and a core comprising a foam. The layer of interpenetrating network of silver nanowires and PEDOT:PSS are wrapped around the core. A wearable device includes a current source comprising a pair of outer electrodes, and voltage sensors comprising one or two pairs of internal electrodes that are arranged between the outer electrodes. At least one electrode of these electrodes is a flexible electrode.
A61B 5/268 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p.ex. des polymères PEDOT:PSS
A61B 5/256 - Moyens pour maintenir le contact de l’électrode avec le corps Électrodes portables, p.ex. avec des sangles ou des bandes
10.
FUNGAL ENDOPHYTES FOR IMPROVED CROP YIELDS AND PROTECTION FROM PESTS
The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.
Disclosed is a reactor thermal management system. A molten salt reactor vessel and a second component (e.g., a drain tank) fluidly coupled with the molten salt reactor vessel are configured to receive a flow of a molten salt therewith. The reactor thermal management system includes an internal shield or vessel encompassing the molten salt reactor vessel and the second component, the internal shield or vessel defining a first thermally insulative region therein. The internal shield or vessel is configured to maintain the first thermally insulated region above a melting temperature of the molten salt during operation of the molten salt reactor vessel.
G21C 15/18 - Dispositions pour le refroidissement d'urgence; Mise hors circuit de la chaleur
G21C 3/54 - Sels fondus, compositions oxydes ou hydroxydes
G21C 11/08 - Ecrans thermiques; Revêtements thermiques, c. à d. pour dissiper la chaleur provenant de radiations gamma qui sans cela chaufferaient un écran biologique externe
‘DALSA 1618’ is an interploid hybrid variety of St. Augustinegrass. ‘DALSA 1618’ possesses a unique combination of drought and shade tolerance that allows its use across the southcentral and southeastern United States.
Board of Regents, The University of Texas System (USA)
The Texas A&M University System (USA)
Inventeur(s)
Scherr, Jonathan
Head, Timothy
Haas, Derek
Shoemate, Jack
Tsvetkov, Pavel
Towell, Rusty
Abrégé
A molten salt reactor system includes a fuel salt system configured to circulate a molten salt through a reactor vessel. The molten salt reactor system further includes an inert gas system fluidically coupled with the fuel salt system and configured to maintain a pressurized volume fluidically between the molten salt and a drain tank by circulating an inert gas along a first inert flow path. The molten salt reactor system further includes an equalization system configured to equalize pressure between all head spaces of the molten salt reactor system including the reactor vessel and the drain tank in response to a shutdown event. The inert gas system is configured to cease maintenance of the pressurized volume in response to the shutdown event.
A method of producing carbon fibers by forming, via a one pot acidic precipitation, a precipitated lignin from a precipitation solution by contacting a lignin solution and an acid solution, wherein the precipitation solution comprises the lignin solution and the acid solution, wherein the lignin solution comprises lignin dissolved in a basic aqueous solution, and wherein the acidic solution has a pH of less than or equal to about 6, 5, 4, 3, or 2; forming precursor fibers from the precipitated lignin; and subjecting the precursor fibers to thermostabilization, carbonization, or both to produce the carbon fibers.
A supersonic flow system in which a supersonic flow is encountered includes a surface configured to be exposed to a supersonic fluid flow, wherein the surface includes an upstream end and a downstream end opposite the upstream end, a wave generator coupled to the surface and including one or more actuators configured to selectably induce strain in the surface, and a wave controller in signal communication with the wave generator and configured to activate the one or more actuators to induce one or more travelling waves configured to travel along the surface between the upstream end and the downstream end of the surface.
B64C 23/04 - Moyens permettant d'influencer l'écoulement d'air sur les surfaces des aéronefs, non prévus ailleurs par génération d'ondes de choc
B64C 21/01 - Propulsion par ingestion de la couche limite [BLI]
F02C 7/04 - Entrées d'air pour ensembles fonctionnels de turbines à gaz ou de propulsion par réaction
F02K 7/14 - Ensembles fonctionnels dans lesquels le fluide de travail est utilisé uniquement sous forme de jet, c. à d. ensembles ne comportant ni turbine ni autre moteur entraînant un compresseur ou une soufflante carénée; Leur commande caractérisés par une compression dans un diffuseur, c. à d. tubulures aéro-thermodynamiques ou statoréacteurs à combustion externe, p.ex. statoréacteurs à combustion supersonique
16.
METHODS AND PLATFORM FOR SCREENING AND SELECTING METABOLITES AND THEIR RECEPTORS
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE TEXAS A&M UNIVERSITY SYSTEM (USA)
Inventeur(s)
Ellington, Andrew
Gollihar, Jimmy
Kao, Katy
Gardner, Elizabeth
Abrégé
Disclosed herein are methods and platforms using Receptor Compartmentalized Partnered Replication (CPR), in which the partner gene is a receptor, signal transduction pathway, or metabolic pathway that leads to the production of an effector molecule for the receptor or signal transduction pathway. The signal transduction pathway or receptor is coupled to the production of a thermostable polymerase. Emulsification of libraries of organisms with primers that can amplify the partner gene led to the selective amplification of those partner genes that were best able to produce the thermostable polymerase during thermal cycling of the emulsion.
C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une transférase
An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein.
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
18.
DOMAIN-SPECIFIC NAMED ENTITY RECOGNITION VIA GRAPH NEURAL NETWORKS
A computer-implemented method of Named Entity Recognition (NER) includes receiving an input, identifying a plurality of candidate entities corresponding to the input, assigning word embeddings to the input at an embedding layer, capturing sequential context of the word embeddings in an encoding layer to obtain encoded word embeddings, constructing an entity relation graph using global coreference relations and local dependency relations to obtain a coreference graph and a dependency graph, fusing the encoded word embeddings, coreference graph, and dependency graph, via a graphical neural network (GNN), to obtain updated word embeddings, and decoding the updated word embeddings via a decoding layer to obtain enriched entity predictions.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes contenant des hétérocycles, p.ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 38/16 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C12N 15/117 - Acides nucléiques présentant des propriétés immunomodulatrices, p.ex. contenant des motifs CpG
Systems and methods for formation of highly reactive alkali dendrites are provided. For example, in some embodiments alkali metals are dissolved in ammonia to form metal electrides after which the ammonia is removed via vacuum to reveal highly activated metal surfaces in the form of crystalline alkali dendrites. The alkali dendrites can mimic powders but have the advantage of being freshly prepared from inexpensive and readily available metal sources. These uniquely activated metals exhibit enhanced reactivity comparatively to similar off the shelf sources of the corresponding metals. For example, the dendrites can have about 100 times greater surface area than conventional metal sources and/or be about 19 times more reactive than powders that serve as the industry standard for the preparation of organometallic compounds. After surface activation, these metals can be used to prepare various organometallic reagents.
C07C 1/32 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés renfermant des hétéro-atomes autres que l'oxygène ou les halogènes, ou en addition à ceux-ci
C07C 45/44 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogène; Préparation des chélates de ces composés par réduction et hydrolyse de nitriles
A system for producing a product is disclosed. The system includes a production facility for producing a product using a chemical process involving chemical reactions, and an information processing device comprising a computer processor that simulates, using a hybrid model, the chemical reactions in the chemical process that produces the product to obtain a predicted output, wherein the hybrid model is a combination of a first-principles model and a data-driven model, determines, using an observer model, expected concentrations and levels of all substrates for the simulated process, sets derived optimal conditions for the chemical process based on the estimated concentrations and levels of all substrates, and predicts future production results based on a current status of the production facility.
In multiple embodiments, a molten salt reactor system may include a heat exchanger within a reactor vessel that also acts as the reactor core (e.g., a shell-and-tube heat exchanger, or a printed circuit heat exchanger), wherein the heat exchanger includes the moderator material so that fission reactions within the nuclear molten fuel salt occur within the heat exchanger. In many embodiments, the in-core heat exchanger of the disclosed molten salt reactor system may include a coolant side and a molten fuel salt side, and the coolant may be a liquid (e.g., non-fissionable molten salt) or a gas (e.g., carbon dioxide). Heat generated from the fission reactions is transferred from the molten fuel salt side to the coolant side. In some embodiments, when the coolant is a gas, the coolant may be utilized with a turbine for power production.
G21C 1/32 - Réacteurs du type intégré, c. à d. réacteurs dans lesquels des parties associées de façon fonctionnelle avec le réacteur, mais non essentielles à la réaction, p.ex. des échangeurs de chaleur, sont disposées à l'intérieur de l'enveloppe avec le cœur
G21C 3/54 - Sels fondus, compositions oxydes ou hydroxydes
An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
In an embodiment, the present disclosure pertains to an ink composition. In some embodiments, the ink composition includes particles composed of a phase change material (PCM) and a resin. In an additional embodiment, the present disclosure pertains to a method of making an ink composition. In general, the method includes forming PCM beads from a PCM and loading a resin with the PCM beads. In a further embodiment, the present disclosure pertains to a method for forming a material or structure. In general, the method includes printing a composite ink on a substrate. In some embodiments, the composite ink includes particles composed of a PCM and a resin. In some embodiments, the method further includes curing the resin to thereby form the material or structure and imparting thermal regulation, by the composite ink, onto the material or structure.
C09K 5/14 - Substances solides, p.ex. pulvérulentes ou granuleuses
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
25.
THERAPEUTIC SMALL MOLECULES FOR TREATMENT OF PULMONARY HYPERTENSION
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
THE TEXAS A&M UNIVERSITY SYSTEM (USA)
Inventeur(s)
Chan, Stephen Yu-Wah
Kim, Seungchan
Abrégé
Disclosed are pathogenic mechanisms in pulmonary hypertension and molecular inhibitors of the same. Particularly, GSTP1 (glutathione S-transferase P1) have been demonstrated as having a role in regulating the endothelial ISCU function in pulmonary hypertension. Accordingly, methods for treating pulmonary hypertension in a subject in need thereof comprising administering a therapeutically effective amount of a pharmaceutical composition that inhibits glutathione S-transferase P (GSTP1) and/or increasing ISCU expression are disclosed. The GSTP1 inhibitor can comprise a piperlongumine analog, such as BRD-K34222889, or a derivative thereof.
A61K 31/4412 - Pyridines non condensées; Leurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une transférase
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
G01N 33/573 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour enzymes ou isoenzymes
Provided herein are monostable adhesive interfaces, for example, a sacrificial bond interface, and self-repairing composite materials that are a layered assembly of magnetic materials and deformable adhesive materials such as a non-linear adhesive material and/or a mechanical adhesive. Also provided is a method for constructing a sacrificial bond composite material and the sacrificial bond composite material constructed by the method.
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 7/08 - Liaison entre couches par des moyens mécaniques
B32B 37/12 - Procédés ou dispositifs pour la stratification, p.ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par l'usage d'adhésifs
C09J 189/00 - Adhésifs à base de protéines; Adhésifs à base de leurs dérivés
27.
Method for Detecting Corrosion Severity of a Metallic Surface on a Pipeline
Provided herein are non-invasive and non-destructive methods for classifying the type of external corrosion defect and the severity thereof in the cathodic protection system on a buried pipeline. Mathematical tools and algorithms are utilized to classify the type and the severity of the corrosion defect.
Systems and methods for controlling end-effectors. In some examples, a system includes a finger-tracking system configured for tracking one or more fingers of an operator and controlling movement of the end effector based on tracking the one or more fingers. The system includes a sensor configured for measuring a distance between the end effector and a target object in an environment of the end effector. The system includes a feedback system configured for electrically stimulating at least one of the one or more fingers of the operator with an electrical pulse having a frequency based on the distance between the end effector and the target object.
B25J 3/04 - Manipulateurs de type à commande asservie, c. à d. manipulateurs dans lesquels l'unité de commande et l'unité commandée exécutent des mouvements correspondants dans l'espace comportant des servomécanismes
B25J 13/08 - Commandes pour manipulateurs au moyens de dispositifs sensibles, p.ex. à la vue ou au toucher
G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
Systems and methods for detecting compromised sensors using dynamic watermarking. In some examples, a method includes injecting a dynamic random signal into an input of a power distribution system. The power distribution system includes at least one sensor and at least one power electronic controller configured to use the at least one sensor. The method includes monitoring a sensor signal from the at least one sensor. The method includes determining whether the at least one sensor is compromised based on a comparison between the dynamic random signal and the sensor signal.
A conformal dipole winding includes a superconducting tape configured with a geometry that orients a face of the superconducting tape to be parallel to a local magnetic field produced by the winding along a length of the superconducting tape. The superconducting tape forms a tape-stack cable formed from a stack of a plurality of the superconducting tapes. A face of each of the superconducting tapes is oriented parallel to the local magnetic field and is in face-face contact with adjacent superconducting tapes.
H01F 6/06 - Bobines, p.ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines
H01B 12/06 - Conducteurs, câbles ou lignes de transmission supraconducteurs ou hyperconducteurs caractérisés par leurs formes à couches ou fils déposés sur des supports ou des noyaux
H01B 12/08 - Conducteurs, câbles ou lignes de transmission supraconducteurs ou hyperconducteurs caractérisés par leurs formes à fils toronnés ou tressés
A heat exchange process includes exchanging heat using a working fluid, where the working fluid comprises a mixture of two or more supercritical fluids, and the mixture is adapted to meet requirements of a heat dissipation temperature from extremely low to very high temperatures. The two or more supercritical fluids can be in a supercritical gaseous state.
F28D 9/00 - Appareils échangeurs de chaleur comportant des ensembles de canalisations fixes en forme de plaques ou de laminés pour les deux sources de potentiel calorifique, ces sources étant en contact chacune avec un côté de la paroi d'une canalisation
F28F 23/00 - Caractéristiques relatives à l'utilisation de matériaux servant pour échange intermédiaire de chaleur, p.ex. emploi de compositions spécifiées
33.
METHOD FOR CREATING CRUDE OIL SYNTHESIZED FLUID HAVING SURFACTANT AND DEMULSIFICATION PROPERTIES
A high voltage discharge generating a plasma wave front is disposed within a headspace over an oil-containing liquid in order to create various chemical changes within the headspace, and ultimately within the liquid in order to inactivate various microbes, synthesize new chemicals, speed separation of a mixture, and aid in oil extraction. Such a discharge may be repeated at an optimum duration and duty-cycle to maximize the chemical effects of the non-equilibrium plasma at a substantially lower temperature than for an equilibrium plasma.
C10G 33/04 - Déshydratation ou désémulsification des huiles d'hydrocarbures par des moyens chimiques
C09K 8/584 - Compositions pour les méthodes de récupération assistée pour l'extraction d'hydrocarbures, c. à d. pour améliorer la mobilité de l'huile, p.ex. fluides de déplacement caractérisées par l'utilisation de tensio-actifs spécifiques
B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaire; Appareils à cet usage
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en général; Appareils appropriés
E21B 43/40 - Séparation associée à la réinjection de matériaux séparés
34.
TREATING OF NEUROLOGICAL DISORDERS USING EXTRACELLULAR VESICLES RELEASED BY HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED NEURAL STEM CELLS
A method for treating a neurological disorder, comprising administering a therapeutically effective amount of extracellular vesicles (EVs) derived from human induced pluripotent stem cell derived neural stem cells (hiPSC-NSCs) to a subject in need thereof. The neurological disorders may, for example, be Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic later sclerosis (ALS), multiple sclerosis, dementia, traumatic brain injury or stroke. A composition comprising EVs derived from hiPSC-NSCs. A kit comprising EVs derived from hiPSC-NSCs.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
35.
SELF-EXCITED BRUSHLESS MACHINE WITH COMPENSATED FIELD WINDINGS
A self-excited brushless machine with compensated field windings includes a rotor and a stator. The rotor Includes a field winding secured to the rotor, an auxiliary winding secured to the rotor, and an energy converter associated with the rotor and configured to convert current between the field winding and the auxiliary winding. The stator includes a multiphase winding. The self-excited brushless machine uses a first current to generate a first magnetomotive force on a stator of the machine, and uses a second current to generate a second magnetomotive force. A third current is induced on auxiliary windings of a rotor of the machine using the second magnetomotive force. A rotor field winding of the machine is excited with the induced currents of the auxiliary windings.
The present invention provides a direct cardiac compression device comprising one or more passive chambers that taper from an aperture to an apex; one or more inflatable active pockets individually independently inflatable, wherein each of the one or more inflatable active pockets is connected to the one or more passive chambers at least partially from the aperture to the apex and wherein the each of the one or more inflatable active pockets does not tension the adjacent one or more inflatable active pockets upon inflation; and a frame in contact with the one or more active chambers to at least partially surround the one or more active pockets.
A61M 60/289 - Dispositifs de circulation mécanique pour assistance de la fonction cardiaque résiduelle par action mécanique sur le cœur natif ou la structure de vaisseaux sanguins du patient, p.ex. dispositifs de compression cardiaque directe
A61M 60/839 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails structurels autres que ceux relatifs à l’entraînement de la pompe des dispositifs pour l'actionnement de la circulation mécanique
A surge gate for blocking a surge of water includes a sleeve disposed below a waterline of the water, wherein the sleeve has an open upper end and a closed lower end, and a piston slidably disposed in the sleeve, wherein the piston is configured to rise vertically within the sleeve along a vertical axis between a first position with an upper end of the piston positioned below the waterline, and a second position with the upper end of the piston positioned above the waterline.
The present invention provides methods and compositions for increasing lignin degradation to produce a biological product. Also provided are methods for increasing expression of laccase in a bacterial species to produce increased lignin degradation. Also provided are bacterial cells and commodities or commodity produces produced from such methods.
The Board of Regents of the University of Texas System (USA)
Inventeur(s)
Cannon, Carolyn L.
Shah, Parth N.
Smolen, Justin A.
Smyth, Hugh D.
Yazdi, Ashkan K.
Herpin, Matthew J.
Abrégé
The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.
A process for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the process as a carrier gas used in spark-discharge hydrocarbon cracking within the process. The process also produces light hydrocarbon liquids which are used to upgrade the heavy oil. An apparatus for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the as a carrier gas used in spark-discharge hydrocarbon cracking within the apparatus. The apparatus also produces light hydrocarbon liquids which are used to upgrade the heavy oil.
C10G 15/12 - Craquage des huiles d'hydrocarbures par des moyens électriques, par des vibrations électromagnétiques ou mécaniques, par des radiations particulaires ou avec des gaz surchauffés dans des arcs électriques avec des gaz surchauffés dans des arcs électriques, p.ex. avec un plasma
C10G 55/04 - Traitement des huiles d'hydrocarbures, en l'absence d'hydrogène, par au moins un procédé de raffinage et par au moins un procédé de craquage uniquement par plusieurs étapes en série comprenant au moins une étape de craquage thermique
42.
AUTOMATED VEHICLE PLATOONING SYSTEMS AND ASSOCIATED METHODS
A vehicle platooning system includes a lead vehicle including a lead powertrain system, a lead steering system, and a lead breaking system, a follower vehicle including a follower powertrain, a follower steering system, a follower braking system, and a follower vehicle control unit wherein the follower powertrain system, the follower steering system, and the follower braking system are each controllable by the vehicle control unit, and a hard connect including a mechanical linkage physically connected between the lead vehicle and the follower vehicle, a sensor unit, and a hard connect control unit configured to control the operation of the follower powertrain system, the follower steering system, and the follower braking system of the follower vehicle based on sensor data provided to the hard connect control unit by the sensor unit.
G08G 1/00 - Systèmes de commande du trafic pour véhicules routiers
B60D 1/62 - Dispositifs auxiliaires comportant des conduites d'alimentation, des circuits électriques ou analogues
G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p.ex. pilote automatique
43.
Reference-Free Foreign Accent Conversion System and Method
Provided herein is a reference-free foreign accent conversion (FAC) computer system and methods for training models, utilizing a library of algorithms, to directly transform utterances from a foreign, non-native speaker (L2) or second language (L2) speaker to have the accent of a native (L1) speaker. The models in the reference-free FAC computer system are a speech-independent acoustic model to extract speaker independent speech embeddings from an L1 speaker utterance and/or the L2 speaker, a speech synthesizer to generate L1 speaker reference-based golden-speaker utterances and a pronunciation correction model to generate a L2 speaker reference-free golden speaker utterances.
G10L 13/027 - Synthétiseurs de parole à partir de concepts; Génération de phrases naturelles à partir de concepts automatisés
G10L 15/06 - Création de gabarits de référence; Entraînement des systèmes de reconnaissance de la parole, p.ex. adaptation aux caractéristiques de la voix du locuteur
G10L 15/16 - Classement ou recherche de la parole utilisant des réseaux neuronaux artificiels
G10L 15/02 - Extraction de caractéristiques pour la reconnaissance de la parole; Sélection d'unités de reconnaissance
A method of determining route safety includes receiving trip information from a user. The trip information includes an origin and a destination. Route alternatives are identified and, for each route alternative, a road network is divided into a plurality of homogenous road segments. Crash data is assigned to each road segment of the plurality of homogeneous road segments. Crash risk is accumulated for each route of the route alternatives. A route with a lowest crash risk is reported to a user.
A method and system for decoding low density parity check (LDPC) codes. An LDPC code decoder includes LDPC decoding circuitry comprising a Q message generator and a P sum adder array. The Q message generator combines an R message from a previous iteration with a P message to produce a Q message. The P sum adder array adds the P message to a difference of an R message from a current iteration and the R message from the previous iteration to produce an updated P message.
H03M 13/11 - Détection d'erreurs ou correction d'erreurs transmises par redondance dans la représentation des données, c.à d. mots de code contenant plus de chiffres que les mots source utilisant un codage par blocs, c.à d. un nombre prédéterminé de bits de contrôle ajouté à un nombre prédéterminé de bits d'information utilisant plusieurs bits de parité
H03M 13/00 - Codage, décodage ou conversion de code pour détecter ou corriger des erreurs; Hypothèses de base sur la théorie du codage; Limites de codage; Méthodes d'évaluation de la probabilité d'erreur; Modèles de canaux; Simulation ou test des codes
Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5′-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
47.
ON-DEMAND ELECTROCHEMICAL REACTIONS IN NANO-ELECTROSPRAY IONIZATION MASS SPECTROMETRY FOR BIOMOLECULAR ANALYSIS
Methods for identifying a structural feature of a lipid include: (a) conducting at least one voltage-controlled electrochemical reaction that converts the lipid to a first derivatized lipid; and (b) fragmenting the first derivatized lipid to generate at least one diagnostic ion indicative of a first structural feature of the lipid.
G01N 33/92 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des lipides, p.ex. le cholestérol
A system for anchoring an offshore vessel to a seabed includes a foundation including a longitudinal axis, a first end, and a second end opposite the first end along the longitudinal axis of the foundation, a keying-flap assembly including a plurality of flaps coupled to the foundation whereby the plurality of flaps are configured to pivot relative to the foundation about a plurality of rotational axes associated with the plurality of flaps, the keying-flap assembly having a run-in configuration in which each of the plurality of flaps occupies a first position, and a set configuration in which the plurality of flaps are pivoted from their first to occupy a plurality of second positions, and a follower configured to apply an extraction force to the foundation to transition the keying-flap assembly from the run-in configuration to the set configuration.
In an embodiment, the present disclosure pertains to method of forming a shape memory polymer (SMP) scaffold. In general, the method includes preparing a salt template, preparing a macromer and/or polymer solution having at least one macromer or polymer, preparing a photoinitiator solution having at least one photoinitiator, adding the macromer and/or polymer solution and the photoinitiator solution to the salt template, exposing the salt template to ultraviolet light, removing the salt template, and forming an SMP scaffold. In some embodiments, the at least one macromer or polymer has at least one star configuration. In an embodiment, the present disclosure pertains to an SMP scaffold having at least one macromer, polymer, or photoinitiator to crosslink a polymer. In some embodiments, the at least one macromer or polymer has a star configuration. The SMP scaffold can be formed via solvent-casting/particulate leaching, electrospinning, additive manufacturing, and combinations thereof.
In some aspects, a magnetic gear system includes a flux focusing magnet arrangement having a low-pole count rotor, a pair of modulator rotors disposed on either side of the low-pole count rotor, and a pair of high-pole count outer rotors disposed outside of the pair of modulator rotors. In some aspects, a magnetic gear system includes a motor with a stator and a pair of low-pole count rotors disposed on either side of the stator. The magnetic gear system further includes a pair of modulator rotors disposed on either side of the motor, and a pair of high-pole outer rotors disposed on opposite sides of the pair of modulator rotors.
The present disclosure provides compositions and methods for long-term storage, shipping, and stable production of black soldier flies, capable of use in waste remediation or protein production. The invention overcomes drawbacks associated with current methods of using black soldier flies, significantly increasing the period during which black soldier fly neonates can be stored and the time in which larvae mature.
A23K 10/37 - Produits alimentaires pour animaux à base de matières d’origine fongique, p.ex. de champignons à base de matières résiduelles
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p.ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
B09B 5/00 - Opérations non couvertes par une seule autre sous-classe ou par un seul autre groupe de la présente sous-classe
Disclosed herein are MXene-aromatic thermosetting copolyester nanocomposites. In one aspect, the nanocomposites can be used to fabricate and/or coat artificial bone implants. In another aspect, the nanocomposites are biocompatible and/or nontoxic. Implants and coatings formed from the nanocomposites possess excellent compressive strength, hardness, and wear resistance in synovial fluid when compared to current implant coatings and materials.
A61L 27/40 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
An embodiment includes a polymer composition comprising a thermoplastic polymer that: (a) is bonded to iodine, (b) includes a vinyl group, and (c) includes urethane linkages. Other embodiments are described herein.
Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
C12N 1/00 - Micro-organismes, p.ex. protozoaires; Compositions les contenant; Procédés de culture ou de conservation de micro-organismes, ou de compositions les contenant; Procédés de préparation ou d'isolement d'une composition contenant un micro-organisme; Leurs milieux de culture
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
An additive manufacturing apparatus includes powder supplies, a preceramic binder supply, and a mixer device downstream from the powder supplies and the preceramic binder supply and configured to generate a powder-integrated preceramic mixture. The additive manufacturing apparatus also includes a nozzle device downstream from the mixer device and configured to output the powder-integrated preceramic mixture, and a heat source configured to heat the powder-integrated preceramic mixture to initiate a self-sustainable ceramization reaction to generate a ceramic matrix composite.
B29C 64/153 - Procédés de fabrication additive n’utilisant que des matériaux solides utilisant des couches de poudre avec jonction sélective, p.ex. par frittage ou fusion laser sélectif
C04B 35/80 - Fibres, filaments, "whiskers", paillettes ou analogues
United States Government as Represented by Department of Veterans Affairs (USA)
The Texas A&M University System (USA)
Inventeur(s)
Cornelius, Lisa K.
Jinadatha, Chetan
Abrégé
A mobile personal protective equipment (PPE) station can comprise a frame that is configured to be movable on a floor surface and a shield that is coupled to the frame. The shield can comprise a front wall that extends along a first horizontal axis. The front wall can define a pair of arm holes. At least a portion of the front wall can be transparent.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The Board of Regents of the University of Texas System (USA)
Inventeur(s)
Meek, Thomas D.
Tseng, Chien-Te
Drelich, Aleksandra
Mellott, Drake M.
Abrégé
Provided herein are pharmaceutical compositions including compounds having Formula I (I) in an effective amount to inhibit non-viral cysteine protease (e.g., mammalian cysteine protease, such as human cathepsin L), as well as methods of using thereof.
Provided herein are pharmaceutical compositions including compounds having Formula I (I) in an effective amount to inhibit non-viral cysteine protease (e.g., mammalian cysteine protease, such as human cathepsin L), as well as methods of using thereof.
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p.ex. pipérazine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
58.
ADDITIVE MANUFACTURING FEEDSTOCK PRODUCTION SYSTEM FOR REACTIVE WIRE AND RELATED METHODS
An additive manufacturing feedstock production system includes a transition roller configured to combine reactive metal foils into combined reactive metal foils with a first combined thickness. The additive manufacturing feedstock production system includes a work roller configured to compress the combined reactive metal foils to a second combined thickness less than the first combined thickness, and a first processing module configured to segment and stack the combined reactive metal foils into stacked reactive metal foils, and feed the stacked reactive metal foils into the work roller. The work roller is configured to repeatedly compress the stacked reactive metal foils into compressed stacked reactive metal foils with a stacked thickness equal to the second combined thickness. The additive manufacturing feedstock production system has a second processing module configured to segment the compressed stacked reactive metal foils into a wire feedstock. An alternative first processing module downstream from the work roller is configured to roll the combined reactive metal foils into rolled reactive metal foils. A work groove roller is downstream from the first processing module and configured repeatedly compress the rolled reactive metal foils into compressed rolled reactive metal foils with a roll diameter equal to a groove diameter into a wire feedstock.
B21B 1/40 - Méthodes de laminage ou laminoirs pour la fabrication des produits semi-finis de section pleine ou de profilés; Séquence des opérations dans les trains de laminoirs; Installation d'une usine de laminage, p.ex. groupement de cages; Succession des passes ou des alternances de passes pour laminer des feuillards présentant des problèmes particuliers, p.ex. à cause de leur faible épaisseur
Methods, systems, and computer readable media for thermal load management of a collection of power consumers managed by an electric power aggregator. In some examples, a system includes a scheduling subsystem, implemented on one or more processors, configured for determining a plurality of cooling or heating control schedules for the collection of power consumers by forecasting one or more wholesale electricity price peaks. The system includes a control system implemented on one or more processors. The control system is configured for carrying out the cooling or heating control schedules at the individual consumer-level. The control system is configured for guaranteeing, for each power consumer of the collection of power consumers, a comfort constraint specified by a bilevel thermostat for the power consumer, wherein the comfort constraint comprises a lower level bound temperature and an upper bound temperature that the power consumer is willing to tolerate.
H02J 3/00 - Circuits pour réseaux principaux ou de distribution, à courant alternatif
H02J 3/14 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par interruption, ou mise en circuit, des charges du réseau, p.ex. charge équilibrée progressivement
60.
CONTINUOUS AND RAPID PERPETUAL ELECTROSTATIC COALESCENCE PHASE SEPARATION AND DEMULSIFICATION OF OIL, WATER, AND SOLIDS USING PLASMA AT STANDARD CONDITIONS
Provided are systems and methods involving a plasma electro-coalescence reactor. The reactor includes a set of ports configured to receive an emulsified mixture into the reactor, receive a non-oxidative gas into the reactor, expel oil from the reactor, and expel water from the reactor. The reactor includes a set of electrodes including a first electrode in a headspace of the reactor, and a second electrode, the set of electrodes configured to receive a voltage at or in excess of a breakdown voltage of the non-oxidative gas.
C10G 33/02 - Déshydratation ou désémulsification des huiles d'hydrocarbures par des moyens électriques ou magnétiques
61.
CONTROL OF NANOPARTICLES DISPERSION STABILITY THROUGH DIELECTRIC CONSTANT TUNING, AND DETERMINATION OF INTRINSIC DIELECTRIC CONSTANT OF SURFACTANT-FREE NANOPARTICLES
A composition including a medium and surfactant-free nanoparticles (SFNPs) at different dispersion state or aggregation form. The composition includes: (a) a composition of a medium and surfactant-free nanoparticles in primary form, wherein the dielectric constant value (DE value) of the medium is equal to or larger than the intrinsic dielectric constant value (IDE) of the SFNPs and smaller than about 1.5 times of the IDE of the SFNPs; (b) a composition of a medium and reaction-limited aggregation form of SFNPs, wherein the DE value of the medium is much larger than the IDE of the surfactant-free nanoparticles; (c) a composition of a medium and diffusion-limited aggregation form of SFNPs, wherein the DE value of the medium is smaller than the IDE of the surfactant-free nanoparticles; and (d) a composition comprising redispersible aggregation form of surfactant-free nanoparticles, wherein the surfactant-free nanoparticles are induced to aggregate in the diffusion-limited fashion in a medium with a DE value that is smaller than the IDE of the surfactant-free nanoparticles.
C08J 3/215 - Formation de mélanges de polymères avec des additifs, p.ex. coloration en présence d'une phase liquide le polymère étant prémélangé avec une phase liquide au moins un additif étant également prémélangé avec une phase liquide
A method is provided for bonding substrates having dissimilar coefficients of thermal expansion, using a thermoset adhesive. The method involves a pre-cure step using radio-frequency energy, followed by a heat-curing step.
C09J 163/00 - Adhésifs à base de résines époxy; Adhésifs à base de dérivés des résines époxy
C09J 5/06 - Procédés de collage en général; Procédés de collage non prévus ailleurs, p.ex. relatifs aux amorces comprenant un chauffage de l'adhésif appliqué
In an embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of an analyte. In an additional embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of analytes. In a further embodiment, the present disclosure pertains to a biosensor having a plurality of discrete compartments in a barcode configuration.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des électrodes enzymatiques, p.ex. avec oxydase immobilisée
Board of Regents, The University of Texas System (USA)
Inventeur(s)
Antao, Dion S.
Zhang, Shiyu
Talebi, Dorsa
Gardner, Matthew C.
Sankarraman, Sri Vignesh
Abrégé
A heatsink for an electric motor, the heatsink comprising a heat spreader configured to be placed in proximity to a winding of the electric motor, a channel formed through the heat spreader and comprising a coolant inlet and a coolant outlet, and a surface feature formed into a back face of the heat spreader that faces the winding and is configured to reduce eddy currents induced in the heatsink.
H02K 9/22 - Dispositions de refroidissement ou de ventilation par un matériau solide conducteur de la chaleur s'encastrant dans, ou mis en contact avec, le stator ou le rotor, p.ex. des ponts de chaleur
H05K 7/20 - Modifications en vue de faciliter la réfrigération, l'aération ou le chauffage
H02K 21/24 - Moteurs synchrones à aimants permanents; Génératrices synchrones à aimants permanents avec des induits fixes et des aimants tournants avec des aimants disposés axialement en face des induits, p.ex. dynamos de bicyclette du type moyeu
65.
SYSTEMS AND METHODS FOR FABRICATING PHYSIOLOGICALLY RELEVANT IN VITRO VESSELS
A method for fabricating an in vitro vessel includes forming a substrate that defines a microfluidic passage therein extending along a longitudinal axis and defined by an inner surface, positioning the substrate in a vertical orientation whereby an acute angle is formed between the longitudinal axis of the microfluidic passage and the direction of gravity, and culturing a plurality of first cells in the microfluidic passage while the substrate is disposed in the vertical orientation whereby an annular layer of the plurality of first cells is formed in the microfluidic channel, wherein the layer of the plurality of first cells defines a lumen extending longitudinally through the microfluidic channel.
A computer implemented method for managing a worksite includes dividing by a worksite optimizer the worksite into a plurality of separate initial operating regions based on a set of input criteria, determining by the worksite optimizer a process chain to be performed by a plurality of machines located at the worksite, adjusting by the worksite optimizer the plurality of initial operating regions based on the process chain to define a plurality of separate final operating regions, and generating by the worksite optimizer a vehicle sequence for at least some of the machines located at the worksite using the plurality of final operating regions.
Portable imaging and taxa classification systems and methods are described. One such method comprises accessing at least one microscopic image captured using an imaging device and a microscope from memory and executing a machine learning (ML) routine on the at least one computing device using a single image frame of the at least one microscopic image as an input to identify a presence of a taxa.
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
68.
MICROFLUIDIC PRESSURE IN PAPER (µPIP) FOR ULTRA LOW-COST PRECISION MICRO TOTAL ANALYSIS SYSTEMS
A method for producing a microfluidic device includes creating a paper channel using a cutting device (e.g., a laser cutter, scissors, dies, blade, or the like), placing the paper channel between two sheets of PDMS, treating the PDMS sheets with a corona plasma to adhere the PDMS sheets together, and using heat to laminate the microfluidic device.
National Technology & Engineering Solutions of Sandia, LLC (USA)
The Texas A&M University System (USA)
Inventeur(s)
Wood, Michael
Grine, Alejandro J.
Serkland, Darwin K.
Kaehr, Bryan James
Hollowell, Andrew E.
Peake, Gregory M.
Ruyack, Alexander
Palermo, Sam
Abrégé
2 with an energy consumption of less than 500 fJ/bit (sum of energy consumed for both a transmitted bit and a received bit). The photonics transceiver is a multi-chip module, where chips in the multi-chip module are tightly integrated with one another. The multi-chip module includes light source, photodetector, photonics, and control/logic chips. The photonics chip includes transparent conducting oxide integrated optical modulators and multiplexers and demultiplexers based on MEMS-tunable optical ring resonators.
G02B 6/42 - Couplage de guides de lumière avec des éléments opto-électroniques
G02B 6/43 - Dispositions comprenant une série d'éléments opto-électroniques et d'interconnexions optiques associées
H04B 10/40 - Systèmes de transmission utilisant des ondes électromagnétiques autres que les ondes hertziennes, p.ex. les infrarouges, la lumière visible ou ultraviolette, ou utilisant des radiations corpusculaires, p.ex. les communications quantiques Émetteurs-récepteurs
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c. à d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
H04B 10/50 - Systèmes de transmission utilisant des ondes électromagnétiques autres que les ondes hertziennes, p.ex. les infrarouges, la lumière visible ou ultraviolette, ou utilisant des radiations corpusculaires, p.ex. les communications quantiques Émetteurs
70.
CONTROLLED THERMAL COEFFICIENT PRODUCT SYSTEM AND METHOD
A controlled thermal coefficient product manufacturing system and method is disclosed. The disclosed product relates to the manufacture of metallic material product (MMP) having a thermal expansion coefficient (TEC) in a predetermined range. The disclosed system and method provides for a first material deformation (FMD) of the MMP that comprises at least some of a first material phase (FMP) wherein the FMP comprises martensite randomly oriented and a first thermal expansion coefficient (FTC). In response to the FMD at least some of the FMP is oriented in at least one predetermined orientation. Subsequent to deformation, the MMP comprises a second thermal expansion coefficient (STC) that is within a predetermined range and wherein the thermal expansion of the MMP is in at least one predetermined direction. The MMP may be comprised of a second material phase (SMP) that may or may not transform to the FMP in response to the FMD.
C21D 9/00 - Traitement thermique, p.ex. recuit, durcissement, trempe ou revenu, adapté à des objets particuliers; Fours à cet effet
B23K 26/38 - Enlèvement de matière par perçage ou découpage
C22F 1/08 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du cuivre ou de ses alliages
C22F 1/10 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du nickel ou du cobalt ou de leurs alliages
C22F 1/18 - Métaux réfractaires ou à point de fusion élevé ou leurs alliages
C21D 8/00 - Modification des propriétés physiques par déformation en combinaison avec, ou suivie par, un traitement thermique
F27D 11/06 - Chauffage par induction, c. à d. dans lequel le matériau à chauffer ou son contenant, ou bien les éléments incorporés dans celui-ci, constitue le secondaire d'un transformateur
F27D 7/06 - Production ou maintien d'une atmosphère particulière ou du vide dans les chambres de chauffage
C21D 1/78 - Traitements thermiques combinés non prévus ci-dessus
B21D 35/00 - Procédés combinant les méthodes de traitement couvertes par les groupes
B23K 26/06 - Mise en forme du faisceau laser, p.ex. à l’aide de masques ou de foyers multiples
B23K 26/14 - Travail par rayon laser, p.ex. soudage, découpage ou perçage en utilisant un écoulement de fluide, p.ex. un jet de gaz, associé au faisceau laser; Buses à cet effet
An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
A multilayer crown includes an outer layer and an inner layer. The outer layer may be formed of a first polymeric material. The inner layer may be formed of a second polymeric material that is different from the first polymeric material. The inner layer may be arranged to contact a tooth so that the inner layer is located between the outer layer and the tooth.
The current invention provides vector constructs that are pre-programmed to self-terminate or self-remove at a predetermined time and methods of making the same. The present invention further provides methods for creating organisms containing these vector constructs. Also provided are various transgenic organisms with the vector constructs, including plants, insects, and mammals.
The present disclosure provides contrast agent compositions comprises a plurality of nanoparticles, such as nanoparticles comprises an iron nanoparticle such as an iron nitride. The disclosure also provides methods for magnetic resonance imaging of the contrast agent compositions as well as other methods of performing magnetic resonance imaging. Further, the disclosure provides kits comprising a contrast agent composition.
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM) caractérisées par un aspect physique particulier, p.ex. émulsions, microcapsules, liposomes
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
75.
Therapeutic Carbon Nanomaterial H2S Oxidants for Biological Polysulfide Synthesis
A therapeutic method for catalytically forming persulfide and/or polysulfide from hydrogen sulfide in vitro and in vivo using endogenously or exogenously released hydrogen sulfide is disclosed. That method comprises contacting cells in need including those under oxidative stress, traumatic brain injury (TBI) and hypoxia, or have an excess of hydrogen sulfide or deficiency of protein persulfidation with oxidized carbon nanoparticulate material in which the particles contain a plurality of carbonyl, hydroxyl and carboxyl substituents. Oxidized carbon nanoparticulate (OCN) material can be prepared from any of a variety of sources of which activated charcoal is preferred. A water-dispersible OCN material is described that does not need added hydrophilic polymers to provide dispersibility for at least 7 days at a concentration of about 1-5 mg/mL. These OCN materials also have a UV absorbance maximum in water of about 220 nm and pass through a 0.22 µm pore PES membrane.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
Methods and compositions for the immunization of animals and humans using an oral immunization or vaccine that comprises B. anthracis Sterne strain 34F2 spores suspended in alginate and coated with a shell containing poly-L-lysine (PEL), a vitelline protein B (VpB), or both and an external coating of alginate in an amount sufficient to protect an animal or human from a lethal dose of anthrax.
A stool includes a base with a post extending therefrom. A seat is connected to a distal end of the post. In some configurations, the seat may be configured to act as a deployable back rest. A deployable anti-fatigue mat is connected to the base. In some configurations, the deployable anti-fatigue mat is attached to the base via a hinged connection. In some configurations, the deployable anti-fatigue mat is attached to the base with a sliding connection that allows the deployable anti-fatigue mat to slide out from the base.
The present disclosure relates to methods of treating Coronavirus-Associated Lung Damage (CALD) and cytokine storm using CALD-treating compounds. The methods can involve administering CALD-treating compounds to a patient suffering from CALD or cytokine storm.
A61K 31/7012 - Composés ayant un groupe carboxyle libre ou estérifié, lié directement ou par une chaîne carbonée, à un atome de carbone du radical saccharide, p.ex. acide glucuronique, acide neuraminique
A61K 31/4468 - Pipéridines non condensées, p.ex. pipérocaïne ayant un atome d'azote lié directement en position 4, p.ex. clébopride, fentanyl
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 31/14 - Antiviraux pour le traitement des virus ARN
79.
Power Electronics Intelligence at the Network Edge (PINE)
A device includes an input converter, an output converter, and a controller. The input converter is electrically coupled to an electrical meter and an energy production array. The output converter is electrically coupled to the energy production array and a load. The controller is communicatively coupled to the input converter, the output converter, the energy production array, and the load. The input converter and the output converter are positioned between the electrical meter and the load.
H02J 3/16 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par réglage de puissance réactive
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p.ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseau; Circuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p.ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
G05B 15/02 - Systèmes commandés par un calculateur électriques
H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs
H02M 5/458 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant alternatif, p.ex. pour changement de la tension, pour changement de la fréquence, pour changement du nombre de phases avec transformation intermédiaire en courant continu par convertisseurs statiques utilisant des tubes à décharge ou des dispositifs à semi-conducteurs pour transformer le courant continu intermédiaire en courant alternatif utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H04B 3/54 - Systèmes de transmission par lignes de réseau de distribution d'énergie
H02J 3/32 - Dispositions pour l'équilibrage de charge dans un réseau par emmagasinage d'énergie utilisant des batteries avec moyens de conversion
H02J 3/12 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau
80.
THERMOPLASTIC AND THERMOSET FOAM NUCLEATION ADDITIVE AND FOAMED MATERIAL
FORMOSA PLASTICS CORPORATION (Taïwan, Province de Chine)
The Texas A&M University System (USA)
Inventeur(s)
Sue, Hung-Jue
Zhao, Mingzhen
Wu, Hong-Mao
Wu, Jen-Long
Kang, Wen-Hao
Lin, Kuei-Pin
Hong, Chiming
Abrégé
A thermoplastic and thermoset foam nucleation additive, which is added to a foamed material, includes a gas absorbent and a nano-compound, wherein the nano-compound and the gas absorbent are mixed to form the thermoplastic and thermoset foam nucleation additive. The gas absorbent includes a central structure and a short chain structure, wherein a first chemical bond is formed between the short chain structure and the central structure. The nano-compound includes a base structure and a long chain structure, wherein a second chemical bond is formed between the long chain structure and the base structure. A number of carbon atoms in the short chain structure is not less than 8, and a molecular weight of the long chain structure is higher than 10000 g/mole.
C08L 23/30 - Compositions contenant des homopolymères ou des copolymères d'hydrocarbures aliphatiques non saturés ne possédant qu'une seule liaison double carbone-carbone; Compositions contenant des dérivés de tels polymères modifiées par post-traitement chimique par oxydation
C08K 5/56 - Composés organométalliques, c. à d. composés organiques contenant une liaison métal-carbone
The present disclosure relates to methods of treating Coronavirus-Associated Lung Damage (CALD) and cytokine storm using CALD-treating polypeptides. The methods can involve administering serum amyloid P-component to a patient suffering from CALD or cytokine storm.
C07D 207/27 - Pyrrolidones-2 avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux autres atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés directement à l'atome d'azote du cycle
C07C 271/22 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes carboxyle
C07D 239/54 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
83.
NALOXONE NANOPARTICLE COMPOSITIONS AND METHODS THEREOF
The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) naloxone. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 31/485 - Dérivés du morphinane, p.ex. morphine, codéine
A61P 25/36 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance aux opiacés
An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61M 29/00 - Dilatateurs avec ou sans moyens pour introduire des agents, p.ex. des remèdes
A process for isolating astatine includes (a) contacting a composition comprising astatine and bismuth with nitric acid to form a first solution comprising astatine, bismuth, and nitric acid; (b) contacting a resin with the first solution so that astatine partitions out of the first solution and into the resin; and (c) eluting astatine from the resin. A composition comprising astatine may be of the formula AtO+X−, wherein X− is a counterion.
B01D 15/12 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la préparation de l'alimentation
B01D 15/42 - Adsorption sélective, p.ex. chromatographie caractérisée par le mode de développement, p.ex. par déplacement ou par élution
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
Processes of polymerizing polyolefins and synthesis of activators. The polymerization processes include polymerizing one or more (C2-C12)α-olefin monomers in the presence of at least one catalyst and at least one co-catalyst to produce a polyolefin. The co-catalyst includes a cation and an anion, in which the anion has a structure having a vinyl terminated alkene, one boron atom or more than one boron atoms, and at least four halogen atoms. The anion of the co-catalysts is incorporated into a polymer chain of the polyolefin.
C08F 210/16 - Copolymères de l'éthylène avec des alpha-alcènes, p.ex. caoutchoucs EP
C08F 4/6592 - Composant couvert par le groupe contenant une liaison métal de transition-carbone contenant au moins un cycle cyclopentadiényle, condensé ou non, p.ex. un cycle indényle ou fluorényle
C08F 4/659 - Composant couvert par le groupe contenant une liaison métal de transition-carbone
87.
ADDITIVE MANUFACTURING OF THERMOSETTING RESINS VIA DIRECT INK WRITING AND RADIO FREQUENCY HEATING AND CURING
In an embodiment, the present disclosure pertains to a method of direct ink writing (DIW). In general, the method includes extruding a resin from a print head, applying radio frequency (RF) heating to the resin, and inducing partial curing of the extruded resin layer-by-layer to thereby form a self-supporting structure. In an additional embodiment, the present disclosure pertains to a system for DIW. In some embodiments, the system includes a print head operable to extrude a resin from a nozzle and an RF applicator.
B29C 64/295 - Fabrication additive, c. à d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p.ex. par impression en 3D, stéréolithographie ou frittage laser sélectif - Détails ou accessoires à cet effet Éléments de chauffage
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
FORMOSA PLASTICS CORPORATION (Taïwan, Province de Chine)
The Texas A&M University System (USA)
Inventeur(s)
Chen, Kwang-Ming
Kao, Jung-Hung
Hsieh, Kun-Pei
Chang, Chao-Shun
Lin, Yen-Ting
Sue, Hung-Jue
Abrégé
The present invention relates to a thermoplastic composition, a thermoplastic composite, and a method for producing the thermoplastic composite. In the method for producing the thermoplastic composite, a polymer, an acid-modified lignin with a specific element content and a compatibilizer with a specific melt flow index and a specific maleic anhydride content are used to produce the thermoplastic composite. Hydroxy groups of the acid-modified lignin react with maleic anhydride groups of the compatibilizer to generate ester bonds via an in-situ reaction catalyzed by acidic groups of the acid-modified lignin to enhance compatibility between the polymer and the lignin, thereby increasing a mechanical strength of the resulted thermoplastic composite.
C08L 51/00 - Compositions contenant des polymères greffés dans lesquels le composant greffé est obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone; Compositions contenant des dérivés de tels polymères
A composition includes a thermoplastic polymer and a polyrotaxane. The polyrotaxane includes a plurality of cyclic molecules and a chain polymer passing through the plurality of the cyclic molecules in a skewering manner, at least a part of the hydroxyl groups of the plurality of cyclic molecules being substituted with a hydrophobic group. A group that enhances miscibility of the polyrotaxane to the thermoplastic polymeris bound to at least a part of the hydrophobic groups of each of the plurality of cyclic molecules.
A method for inspecting a photomask includes scanning the photomask with an interferometric fringe pattern generated by an interferometer, generating an interferogram associated with the photomask in response to scanning the photomask using the interferometer, and detecting one or more geometric parameters of the photomask using the generated interferogram.
G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
G01B 11/25 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes en projetant un motif, p.ex. des franges de moiré, sur l'objet
Methods and systems of 3D printing non-photocurable thermosetting polymer materials and continuous fiber composites that reduces the manufacturing time and energy required by implementing fast, self-sustaining, and self-propagating, in-situ curing of the polymer and the and continuous fiber composites as the non-photocurable thermosetting polymer materials are being printed.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux
An electric machine includes a stator having a plurality of stator teeth. Each stator tooth of the plurality of stator teeth includes a winding disposed there around. Each stator tooth of the plurality of stator teeth is shaped to receive a plurality of microchannels. The microchannels contain a circulating heat-transfer fluid; Each stator tooth of the plurality of stator teeth is thermally exposed to the heat-transfer fluid via the plurality of microchannels so as to effectuate heat removal from each stator tooth of the plurality of stator teeth.
H02K 9/22 - Dispositions de refroidissement ou de ventilation par un matériau solide conducteur de la chaleur s'encastrant dans, ou mis en contact avec, le stator ou le rotor, p.ex. des ponts de chaleur
H02K 9/20 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p.ex. de l'huile dans lesquels l'agent de refroidissement se vaporise dans l'enveloppe de la machine
H02K 21/24 - Moteurs synchrones à aimants permanents; Génératrices synchrones à aimants permanents avec des induits fixes et des aimants tournants avec des aimants disposés axialement en face des induits, p.ex. dynamos de bicyclette du type moyeu
A resin composition is provided. The resin composition includes a rigid polymer resin, a functionalized polyrotaxane, and (optionally) a core-shell polymer. The resin composition may be cured to form a cured thermoset resin. The cured thermoset set has improved mechanical properties relative to a reference cured thermoset. A method of preparing a cured article of the curable resin composition is also provided. The method includes providing the curable resin composition and curing the curable composition.
C08L 79/04 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale; Polyhydrazides; Polyamide-acides ou précurseurs similaires de polyimides
94.
NEUROSTEROID COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS
Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids.
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
C07J 5/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de deux atomes de carbone, p.ex. prégnane, et substitués en position 21 par seulement une unique liaison carbone-oxygène
C07J 41/00 - Stéroïdes normaux contenant un ou plusieurs atomes d'azote n'appartenant pas à un hétérocycle
95.
COMPOSITIONS OF STABLE FORMULATIONS OF VARENICLINE SALT OR BASE FORM WITH CONTROL ON NITROSO IMPURITIES
In an embodiment, the present disclosure pertains to a stable formulation of a varenicline salt or base form containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer. In some embodiments, the composition includes varenicline and at least one pharmaceutical excipient. In some embodiments, the at least one pharmaceutical excipient includes a magnesium salt and at least one of dicalcium phosphate, polyethylene glycol, or polyethylene oxide. In some embodiments, the magnesium salt can include, without limitation, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium carbonate, magnesium oxide, magnesium silicate, magnesium stearate, magnesium sulfate, magnesium trisilicate, and combinations thereof. In some embodiments, a weight ratio of the varenicline to the at least one pharmaceutical excipient ranges from 1 to 99 to 99 to 1% w/w. In some embodiments, the at least one pharmaceutical excipient is a protective pharmaceutical ingredient.
Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
Embodiments of the present disclosure pertain to methods of selecting cyclic peptides that bind to a target by transforming a phage display library with a plurality of nucleic acids into bacterial host cells, where the nucleic acids include phage coat protein genes with a combinatorial region that encodes at least one cysteine and at least one non-canonical amino acid. The transformation results in the production of phage particles with phage coat proteins where the cysteine and the non-canonical amino acid couple to one another to form a cyclic peptide library. Phage particles are then screened against the desired target to select bound cyclic peptides. Amino acid sequences of the selected cyclic peptides are then identified. Additional embodiments pertain to methods of constructing a phage display library that encodes the cyclic peptides. Further embodiments of the present disclosure pertain to the produced cyclic peptides, phage display libraries and phage particles.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
98.
STABLE PHARMACEUTICAL COMPOSITIONS OF METFORMIN WITH CONTROL ON NITROSO IMPURITIES
In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer. In some embodiments, the composition includes metformin and at least one pharmaceutical excipient. In some embodiments, the at least one pharmaceutical excipient includes a magnesium salt and at least one of a calcium salt, dicalcium phosphate, polyethylene glycol, or polyethylene oxide. In some embodiments, the magnesium salt can include, without limitation, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium carbonate, magnesium oxide, magnesium silicate, magnesium stearate, magnesium sulfate, magnesium trisilicate, and combinations thereof. In some embodiments, a weight ratio of the drug to the at least one pharmaceutical excipient ranges from 1 to 99 to 99 to 1% w/w. In some embodiments, the at least one pharmaceutical excipient is a protective pharmaceutical ingredient.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol o
A61K 33/06 - Aluminium, calcium ou magnésium; Leurs composés
A61K 47/10 - Alcools; Phénols; Leurs sels, p.ex. glycérol; Polyéthylène glycols [PEG]; Poloxamères; Alkyléthers de PEG/POE
Provided herein are medical devices, systems and platforms to monitor tissue properties such as oxygen saturation, temperature and degree of tissue edema for diagnosis and post-operative patient monitoring. The medical devices may be handheld or portable or may be removable patches. The medical devices utilize light of various visible and near-infrared wavelengths to interrogate a tissue where the intensities of reflected light correlate to one or more tissue property. Also provided are methods for measuring tissue properties, for detecting pressure ulcers and for remotely monitoring in real time a surgical flap on a post-operative subject via the medical devices.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale
A61B 5/0205 - Evaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p.ex. de l'état cardiaque et respiratoire
A61B 5/0537 - Mesure de la composition du corps par impédance, p.ex. de l’hydratation des tissus ou de la teneur en graisses
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
A61B 5/01 - Mesure de la température de parties du corps
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Embodiments of the present disclosure pertain to a sensor that includes a transduction agent, a plurality of analyte binding agents immobilized on the transduction agent, and a coating agent that forms a coating around at least some of the analyte binding agents. Further embodiments of the present disclosure pertain to methods of detecting one or more analytes in a sample by associating the sample with a sensor of the present disclosure; detecting a signal from the sensor; and correlating the signal to the presence or absence of the one or more analytes in the sample. Additional embodiments of the present disclosure pertain to methods of making the sensors of the present disclosure by immobilizing a plurality of analyte binding agents on a transduction agent; and coating at least some of the analyte binding agents with a coating agent to form a sensor.
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
B82Y 40/00 - Fabrication ou traitement des nanostructures
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p.ex. génie protéique ou administration de médicaments
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
brevets
