Systems and methods for electrochemical hydrogen looping cells are described. Generating a pH swing can expedite carbon dioxide capture from oceanwater. Many embodiments implement electrochemical hydrogen looping cells that simultaneously produce acid via anodic hydrogen oxidation and base via cathodic hydrogen evolution to generate a pH change.
C25B 9/19 - Cellules comprenant des électrodes fixes de dimensions stables; Assemblages de leurs éléments de structure avec des diaphragmes
C25B 11/032 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées Électrodes poreuses Électrodes à diffusion de gaz
C25B 13/04 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Éléments d'espacement caractérisés par le matériau
C25B 9/65 - Dispositifs pour l'alimentation en courant; Connexions d'électrodes; Connexions électriques intercellulaires
C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
Disclosed herein include methods, compositions, and kits suitable for use in signal amplification. There are provided, in some embodiments, protease-based signal amplification modules. Disclosed herein include amplifier proteins comprising a first part of a first protease domain, a first dimerization domain, a first cut site a protease in a protease active state is capable of cutting, a second dimerization domain, a second cut site a protease in a protease active state is capable of cutting, and a first caging domain. Disclosed herein include companion amplifier proteins comprising a second part of a first protease domain, a third dimerization domain, a third cut site a protease in a protease active state is capable of cutting, a fourth dimerization domain, a fourth cut site a protease in a protease active state is capable of cutting, and a second caging domain.
C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C12N 9/48 - Hydrolases (3.) agissant sur les liaisons peptidiques, p.ex. thromboplastine, aminopeptidase de la leucine (3.4)
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
A61K 38/00 - Préparations médicinales contenant des peptides
3.
SYSTEMS AND METHODS FOR MONITORING THE SURFACE TEMPERATURE OF AN OBJECT USING THE TEMPERATURE-DEPENDENT ABSORPTION PROPERTIES OF SEMICONDUCTORS
A temperature monitoring system includes a semiconductor member mounted onto the surface of an object having a surface whose temperature is to be monitored. The semiconductor member has a temperature-dependent bandgap with an absorption edge that varies with temperature. A light source is configured to illuminate the semiconductor member with monochromatic light. The monochromatic light has a wavelength equal to an absorption edge wavelength that is associated with the absorption edge when the semiconductor member is at a specified temperature. A detector is configured to receive light reflected from the semiconductor member when illuminated with the monochromatic light such that a surface temperature of the object is at the specified temperature when a change in an amount of reflected light that is received indicates that the wavelength of the monochromatic light is equal to the absorption edge wavelength at the specified temperature.
G01K 7/01 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments semi-conducteurs à jonctions PN
The present disclosure is directed toward systems and methods for measuring electric current in a multi-wire cable, as well as the apparent and real power associated with an electrical load connected to the cable. A probe comprising an array of small form-factor, high-speed magnetometers is operatively coupled with the cable such that the magnetometers partially surround the cable. Each magnetometer detects the composite magnetic field at its location, and this plurality of measurements is used to generate a magnetic-field map. The contributions of the current flow in each wire are identified by deconvolving the magnetic-field map, enabling their locations to be determined and monitoring of the current and power flow. A sensor included in the probe is used to determine the phase of the applied voltage. The phase difference between the voltage and current is then used to determine the real power dissipation of the load.
G01R 15/12 - Circuits pour appareils de test à usage multiple, p.ex. pour mesurer, au choix, tension, courant ou impédance
G01R 15/20 - Adaptations fournissant une isolation en tension ou en courant, p.ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs galvano-magnétiques, p.ex. des dispositifs à effet Hall
G01R 19/145 - Indication de l'existence d'un courant ou d'une tension
G01R 19/15 - Indication de l'existence d'un courant
G01R 21/06 - Dispositions pour procéder aux mesures de la puissance ou du facteur de puissance par mesure du courant et de la tension
G01R 15/14 - Adaptations fournissant une isolation en tension ou en courant, p.ex. adaptations pour les réseaux à haute tension ou à courant fort
G01R 15/18 - Adaptations fournissant une isolation en tension ou en courant, p.ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs inductifs, p.ex. des transformateurs
G01R 19/14 - Indication du sens d'un courant; Indication de la polarité d'une tension
G01R 19/06 - Mesure de la composante réelle; Mesure de la composante réactive
G01R 21/08 - Dispositions pour procéder aux mesures de la puissance ou du facteur de puissance en utilisant des dispositifs à effet galvanomagnétique, p.ex. des dispositifs à effet Hall
5.
ALL-INTEGRATED COMPLEX SIGNAL GENERATION AND PROCESSING
An integrated photonic architecture for coherent signal generation and processing. This architecture can enhance coherent transceiver performance for many applications, including remote sensing, LiDAR, high-speed data communication, and high performance computing.
G02B 6/12 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES - Détails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p.ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
6.
LITHIUM-RICH ALUMINUM IRON SULFIDE Li-ION BATTERY CATHODES
w-δxz22. In some embodiments, w may be greater than or equal to 2 and less than or equal to 2.5. In some embodiments, x may be greater than 0 and less than or equal to 0.5. In some embodiments, z may be greater than 0 and less than or equal to 1. In some embodiments, δ may be greater than or equal to 0 and less than w. In some embodiments, the composition may have a net charge of 0.
C01B 17/22 - Sulfures ou polysulfures de métaux alcalins
C25B 11/042 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par le matériau Électrodes à base d’un seul matériau
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p.ex. phosphates, silicates ou borates
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif
7.
METHOD FOR CARDIAC AUSCULTATION USING BLOOD PRESSURE CUFF
The disclosure relates to systems and methods for noninvasively performing cardiac auscultation. In some implementations, a method includes: performing, using a BP cuff of a BP cuff system, a blood pressure measurement of a subject to obtain one or more blood pressure values corresponding to the subject; inflating, based on the one or more blood pressure values corresponding to the subject, the BP cuff to a subject specific pressure value; capturing, using the BP cuff system, while the BP cuff is inflated to the subject specific pressure value, a pulse pressure waveform signal associated with an artery of the subject; obtaining a sound waveform signal associated with a heart valve of the subject by filtering the pulse pressure waveform signal to extract sound components associated with the opening or closing of the heart valve; and analyzing the sound waveform signal to identify characteristics of the heart of the subject.
A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
A61B 5/0245 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques
8.
HYBRIDIZATION CHAIN REACTION LATERAL FLOW ASSAYS FOR AMPLIFIED DETECTION OF A TARGET IN A SAMPLE
The present disclosure relates to an HCR lateral flow device for amplified detection of a target in a sample and methods of using the same. In some embodiments, the device and methods of use combine the sensitivity of HCR signal amplification with the simplicity of the lateral flow assay format to facilitate user-friendly amplified detection of a target in a sample.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
An electrostatic ion trap or an array of electrostatic ion traps are provided having a longitudinal length of no more than 10 mm and/or at least one electrode with a capacitance to ground of no more than 1 pF. First and second sets of planar electrodes may be distributed along the longitudinal axis, at least some of the which are configured to receive an electrostatic potential for confinement of ions received in the space between the first and second sets of planar electrodes. An array may comprise an inlet for receiving an ion beam, configured such that a portion of the ion beam can be trapped in each of the ion traps. Signals indicative of ion mass and charge data may be obtained from multiple electrostatic ion traps in the array. This mass and charge data may be combined for identification of components of a mixture of different analyte ions.
An optical arrangement splits an optical beam into multiple beamlets and focuses each beamlet at a respective line. Each line is defined with reference to a respective spatially-separated location across at least one dimension, such that each beamlet photofragments distinct ions confined at the respective location. Each of the spatially-separated locations may correspond with a respective trapping region of one of an array of ion traps.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
NTT RESEARCH, INC. (USA)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventeur(s)
Nehra, Rajveer
Yanagimoto, Ryotatsu
Hamerly, Ryan
Ng, Edwin
Marandi, Alireza
Mabuchi, Hideo
Abrégé
Methods and systems are presented for using optical parametric amplifiers in various ways that enhance a native quadratic coupling strength so that a photonic component of interest can be measured or otherwise observed without demolishing the component of interest at a system output. For example such components may include a number of signal Bogoliubov excitations, a pump modular quadrature, or a signal quadrature squared.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p.ex. calcul quantique ou logique à un électron
G06N 10/60 - Algorithmes quantiques, p.ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
G06N 10/80 - Programmation quantique, p.ex. interfaces, langages ou boîtes à outils de développement logiciel pour la création ou la manipulation de programmes capables de fonctionner sur des ordinateurs quantiques; Plate-formes pour la simulation ou l’accès aux ordinateurs quantiques, p.ex. informatique quantique en nuage
12.
METHODS AND CULTURE MEDIA FOR GENERATING EMBRYOS IN VITRO FROM PLURIPOTENT STEM CELLS
in vitroGATA6SOX17GATA3TFAP2CTFAP2C gene) under a condition in a culture medium allowing the pluripotent stem cells to self-organize into a post-implantation embryo structure. In some embodiments, the pluripotent embryonic stem cells are human pluripotent embryonic stem cells and the generated synthetic embryo is a human embryo.
Disclosed herein include methods and compositions for use in generating synthetic embryos. In some embodiments, the method comprises culturing stem cells that over-express at least one Cadherin.
Methods for utilizing irradiation to selectively transform insulating self-developing resists, such as metal fluorides, into electrically conductive metals are described. The disclosed methods enable the fabrication of electrical components and structures with critical dimensions below 5 nanometers. Selective irradiation induces the conversion of insulating metal fluoride compounds into metals in predefined regions. Examples of applications include miniature wiring, quantum point contacts, miniature electroplating and via-holes fabrication by using fluoride as etching mask.
H01L 21/033 - Fabrication de masques sur des corps semi-conducteurs pour traitement photolithographique ultérieur, non prévue dans le groupe ou comportant des couches inorganiques
H01L 21/3213 - Gravure physique ou chimique des couches, p.ex. pour produire une couche avec une configuration donnée à partir d'une couche étendue déposée au préalable
H01L 21/768 - Fixation d'interconnexions servant à conduire le courant entre des composants distincts à l'intérieur du dispositif
H01L 21/288 - Dépôt de matériaux conducteurs ou isolants pour les électrodes à partir d'un liquide, p.ex. dépôt électrolytique
15.
FEATURES EXTRACTION NETWORK FOR ESTIMATING NEURAL ACTIVITY FROM ELECTRICAL RECORDINGS
An apparatus and method for a feature extraction network based brain machine interface is disclosed. A set of neural sensors sense neural signals from the brain. A feature extraction module is coupled to the set of neural sensors to extract a set of features from the sensed neural signals. Each feature is extracted via a feature engineering module having a convolutional filter and an activation function. The feature engineering modules are each trained to extract the corresponding feature. A decoder is coupled to the feature extraction module. The decoder is trained to determine a kinematics output from a pattern of the plurality of features. An output interface provides control signals based on the kinematics output from the decoder.
A61B 5/37 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG] Électroencéphalographie intracrânienne [EEG IC], p.ex. électrocorticographie [ECoG]
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/291 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
A61B 5/293 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG] invasives
A61B 5/256 - Moyens pour maintenir le contact de l’électrode avec le corps Électrodes portables, p.ex. avec des sangles ou des bandes
A complex-wavefront photonic transceiver including a coherent source; a complex transmitter waveform generator programmable to modulate a first portion of the coherent electromagnetic radiation, when received from the coherent source, to form a complex waveform comprising at least a pre-distortion to compensate for, or an adaptive beamforming to determine, a distortion of the complex waveform caused by at least the transceiver or during transmission of the complex waveform to a receiver aperture, the receiver aperture outputting receiver signals in response thereto; and a transmitter aperture for transmitting the complex waveform when received from the complex transmitter waveform generator. The transceiver further includes a receiver processor programmable to determine a phase and amplitude of the complex waveform, when received on the receiver aperture, from a combination of the received signals with a second portion of the electromagnetic radiation.
G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
G01S 17/34 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées utilisant la transmission d'ondes continues modulées en fréquence, tout en faisant un hétérodynage du signal reçu, ou d’un signal dérivé, avec un signal généré localement, associé au signal transmis simultanément
H04N 23/55 - Pièces optiques spécialement adaptées aux capteurs d'images électroniques; Leur montage
H04N 25/709 - Circuits de commande de l'alimentation électrique
H01S 3/00 - Lasers, c. à d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
G02B 6/12 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES - Détails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p.ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
17.
THERAPEUTIC NEUTRALIZING ANTIBODIES FOR SARS-COV-2
Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.
Methods and devices to split electromagnetic waves across broad bandwidths in correspondence with orbital angular momentum states combined with orthogonal polarization states are disclosed. The described methods can be used in fiber communication and imaging systems. The devices include three-dimensional (3D) scattering structures that can be using existing CMOS processes and direct write lithography techniques. Performance metrics based on the intensity and contrast of the split electromagnetic waves are also disclosed.
G02B 1/00 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques caractérisés par la substance dont ils sont faits; Revêtements optiques pour éléments optiques
G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser
G02B 27/09 - Mise en forme du faisceau, p.ex. changement de la section transversale, non prévue ailleurs
G02B 27/10 - Systèmes divisant ou combinant des faisceaux
19.
WEARABLE MICROFLUIDIC BIOAFFINITY SENSOR FOR AUTOMATIC MOLECULAR ANALYSIS
Some implementations of the disclosure relate to a wearable biosensor device including an iontophoresis module configured to stimulate production of a sweat sample from skin of a user, the sweat sample including biomarkers; a microfluidic module configured to collect the sweat sample, mix the sweat sample with labeled detection reagents to obtain a mixture including the biomarkers bound to the labeled detection reagents, and route the mixture to a detection reservoir of the microfluidic module; and a sensor assembly including a bioaffinity sensor configured to quantify the biomarkers of the mixture in the detection reservoir to determine a concentration of the biomarkers present in the sweat sample. The bioaffinity sensor includes an electrode functionalized to bind to the biomarkers of the mixture. The bioaffinity sensor can quantify the biomarkers to determine their concentration with a sensitivity on the order of nanomoles or picomoles.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des électrodes enzymatiques, p.ex. avec oxydase immobilisée
A61N 1/30 - Appareils d'ionothérapie ou d'électrophorèse
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
20.
HOST DEPLETION AND MICROBIAL ENRICHMENT OF A BIOLOGICAL SAMPLE AND RELATED METHODS AND SYSTEMS
Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
21.
A SYNTHETIC PROTEIN-LEVEL NEURAL NETWORK IN MAMMALIAN CELLS
Disclosed herein include methods, compositions, and kits suitable for use in winner-take-all neural network computation in mammalian cells. In some embodiments, de novo designed protein heterodimers and engineered viral proteases are combined to implement a synthetic protein circuit that performs winner-take-all neural network computation. The synthetic protein circuit can include modules that compute weighted sums of input protein concentrations through reversible binding interactions, and allow for self-activation and mutual inhibition of protein components using irreversible proteolytic cleavage reactions.
Systems and methods for catalyzed asymmetric bipolar membranes are described. Catalyzed asymmetric bipolar membranes can sustain desired current densities under low operational voltage for prolonged time periods. Catalyzed asymmetric bipolar membranes can be implemented in electrodialysis cells for various applications such as carbon capture.
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p.ex. par électro-osmose, électrodialyse, électrophorèse
C02F 1/42 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par échange d'ions
C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
A synchronization system for synchronizing photons in a quantum teleportation network. The synchronization system includes a multiplexer combining a clock pulse with a signal photon (carrying a qubit) in an optical fiber, the optical fiber connecting a transmitter node (including the multiplexer) and a receiver node (comprising a demultiplexer). The signal photons have signal wavelengths red shifted as compared to clock wavelengths of the clock pulses. The clock pulses have an intensity below a threshold, such that Raman scattering of the clock pulses by the fiber (shifting the clock wavelengths into the signal wavelengths) is negligible. The receiver node comprises a demultiplexer demultiplexing the one of the signal photons and the one of the clock pulses; a first detector detecting the one of the signal photons; and a second detector detecting the one of the clock pulses.
An implantable medical device to restore brain-controlled movement and sensation after neural injury. The device comprises a brain-computer interface capable of acquiring electrocorticogram (ECoG) signals recorded directly from the surface of the brain and uses the signals to enable direct control of paralyzed muscles, limbs or extremities while simultaneously receiving signals from external sensors and converting them into electrical stimulation patterns for the brain's sensory areas.
Provided herein are HIV immunogens and uses thereof for generating an immune response in a subject. This disclosure further provides a method for treating or preventing a human immunodeficiency type I (HIV-I) infection in a subject using the disclosed HIV immunogens and/or antibodies generated by any of the methods disclosed herein.
3-z13 3 (FX1); wherein Q is a first dopant being a substitute for B in the composition and being one or more elements each aliovalent with respect to B; wherein G is a second dopant being a substitute for S in the composition and being one or more elements each aliovalent with respect to S; wherein z is a number greater than 0 and less than or equal to 0.40, optionally less than or equal to 0.05; and wherein the composition comprises only the first dopant, only the second dopant, or both the first dopant and the second dopant.
The present disclosure describes, in part, soluble single-chain dimers (sSCDs) generated from cleavable single-chain trimers (cSCTs), compositions and methods for their production, as well as applications thereof related to characterization of antigen-specific CD8+ T cells and treatments.
A photonic integrated circuit comprising one or more waveguides comprising a second order non-linearity configured to operate on optical pulses each having a pulse length shorter than 1000 optical cycles, as measured at their full width at half maximum. The circuit is configured to generate one or more quantum states carried by one or more of the optical pulses, manipulate one or more of the quantum states, and/or measure one or more of the quantum states.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p.ex. codes de surface ou distillation d’état magique
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p.ex. calcul quantique ou logique à un électron
29.
NUCLEAR SPIN WAVE QUANTUM REGISTER FOR SOLID STATE QUANTUM NETWORK NODES
A system for coupling a qubit to a register, wherein the system controls application of a protocol comprising a sequence of pulses synchronized with an RF field, the protocol further comprising a timing, a phase, and a duration of each of the pulses comprising a single qubit gate, a period and amplitude of the RF field, and a number of repeats of the sequence, so that application of the protocol controls a coherent spin exchange interaction between a register and a qubit having a zero magnetic dipole moment. The qubit comprises a first spin state and a second spin state both of which have a zero magnetic dipole moment; the register comprises multiple register spins having an energy level structure; and the register spins are indistinguishable so as to be configurable in basis states including a superposition state used for storing the quantum state of the qubit.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p.ex. calcul quantique ou logique à un électron
30.
NON-UNIFORM-THICKNESS LAYERS AND METHODS FOR FORMING
The present disclosure is directed toward the simultaneous formation of a plurality of optical elements on a common substrate, where each optical element includes at least one layer having a desired non-uniform-thickness variation. Each such layer is formed such that it includes a plurality of material patterns characterized by the non-uniform thickness variation, where each material pattern is disposed on a different deposition site on the substrate. The material patterns are configured such that adjacent optical elements are separated by a boundary region for facilitating dicing of the substrate into individual optical elements. The non-uniform-thickness layer is formed by direct deposition through a shadow mask that includes a plurality of mask patterns that are either (1) configured to pass material flux in a non-uniform manner or (2) configured to shadow different portions of their respective deposition regions while being moved relative to the substrate.
B05D 5/06 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir des effets multicolores ou d'autres effets optiques
B32B 3/08 - Caractérisés par des caractéristiques de forme en des endroits déterminés, p.ex. au voisinage des bords caractérisés par des éléments ajoutés à des endroits déterminés
B32B 3/30 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche comportant des cavités ou des vides internes caractérisés par une couche comportant des retraits ou des saillies, p.ex. des gorges, des nervures
H01L 21/308 - Traitement chimique ou électrique, p.ex. gravure électrolytique en utilisant des masques
B05D 7/24 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers pour appliquer des liquides ou d'autres matériaux fluides particuliers
H01L 21/68 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitement; Appareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le positionnement, l'orientation ou l'alignement
An adaptive LiDAR includes, in part, a transmitter and a receiver. The transmitter includes, in part, an array of N radiators, and a transmitter control block adapted to control an aperture of the transmitter. The receiver includes, in part, an array of T receive elements, and a receiver control block adapted to control a scan rate and resolution of the receiver. M and T are integers greater than one.
G01S 17/894 - Imagerie 3D avec mesure simultanée du temps de vol sur une matrice 2D de pixels récepteurs, p.ex. caméras à temps de vol ou lidar flash
G01S 7/4911 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe - Détails des systèmes non pulsés Émetteurs
A macromolecular mechanophore platform that undergoes a mechanically gated chromogenic reaction in the presence of an extrinsic small molecule developing reagent is described, along with methods of synthesis and use thereof in different scenarios. The platform comprises a hetero-Diels Alder adduct embedded into a polymer, wherein the hetero-Diels Alder adduct masks an activated furan, and wherein the activated furan is released from the platform upon application of mechanical force, to react with the developing reagent comprising a secondary amine of choice to produce colored species with photoswitch capabilities. The platform can be used in solution or in solid state, and different colors can be obtained for the same platform, since the color of the generated product is determined by the choice of the developing reagent. Incorporating the platform into polymeric materials enables multicolor mechanical lithography by sequential application of mechanical force and different developing reagents.
G03F 7/105 - Matériaux photosensibles - caractérisés par des détails de structure, p.ex. supports, couches auxiliaires avec des substances, p.ex. des indicateurs, pour obtenir des images visibles
G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
G03F 7/32 - Compositions liquides à cet effet, p.ex. développateurs
C08F 8/32 - Introduction d'atomes d'azote ou de groupes contenant de l'azote par réaction avec des amines
Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e.g., CNS). In some embodiments, the BBB-crossing receptor is carbonic anhydrase IV. Disclosed herein also include recombinant adeno-associated viruses (rAAVs) with increased specificity and transduction efficiency across the BBB and related compositions and methods of treating various diseases and conditions.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation utilisant la micro-encapsulation, p.ex. utilisant des vésicules liposomiques
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 16/40 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre des enzymes
A61K 38/00 - Préparations médicinales contenant des peptides
34.
THIN-FILM STRUCTURES FOR OPTICAL APPLICATIONS COMPRISING FLUORIDE MIXTURES
An optica I -th in -film structure comprises a low-index optical thin film consisting essentially of co-deposited Barium Fluoride and a secondary fluoride compound, and a high-index optical thin film.
G01D 5/26 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c. à d. utilisant de la lumière infrarouge, visible ou ultraviolette
Disclosed herein include methods, compositions, and kits suitable for use in generating barcoded detection particles. Each barcoded detection particle can comprise a particle associated with an antigen-binding protein and a plurality of barcoding oligonucleotides. The plurality of barcoding oligonucleotides can comprise a first ligand. The particle can comprise a second ligand. The plurality of barcoding oligonucleotides can be associated with the particle via a multivalent binding agent comprising two or more binding moieties capable of binding the first ligand and/or the second ligand. There are provided, in some embodiments, methods for detecting interactions between nucleic acid molecules and proteins of interest. Methods for detecting interactions between ribonucleic acid molecules and RNA-binding proteins (RBPs) are also provided herein.
C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 33/536 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide
C08L 23/18 - Homopolymères ou copolymères d'hydrocarbures contenant au moins quatre atomes de carbone
C08L 101/00 - Compositions contenant des composés macromoléculaires non spécifiés
C08F 255/08 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères d'hydrocarbures tels que définis dans le groupe sur des polymères d'oléfines contenant au moins quatre atomes de carbone
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
37.
HIGH THROUGHPUT MICROCRYSTAL SOAKING FOR STRUCTURAL ANALYSIS OF PROTEIN-LIGAND INTERACTIONS HIGH THROUGHPUT MICROCRYSTAL SOAKING FOR STRUCTURAL ANALYSIS OF PROTEIN-LIGAND INTERACTIONS
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01D 53/02 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse
39.
SUPPRESSION OF NON-SPECIFIC SIGNALS BY EXONUCLEASES IN FISH EXPERIMENT
Disclosed herein is a composition for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a kit for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a method for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples.
in vitroin vitro culture of synthetic embryos from mammalian pluripotent stem cells and extra-embryonic stem cells. The methods and compositions described herein can generate synthetic embryos at different developmental stage reaching early organogenesis and beyond. Disclosed herein also include an embryo culturing system and methods of using same.
C12N 5/073 - Cellules ou tissus embryonnaires; Cellules fœtales ou tissus fœtaux
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
41.
SYSTEMS AND METHODS FOR POWERING AUTONOMOUS SWEAT SENSOR
Systems and methods for a self-powered wireless wearable sensor system include a photovoltaic (PV) panel array, used as a power source for a wearable sensor. The PV panel array may be attached to an area of the human body exposed to a light source. Exposure to a light source may generate an electric field and power a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system may include a microfluidic sweat sensor patch that may be connected to lower-power wireless sensor circuitry for regulating power efficiently and may be powered by the PV panel array.
B01D 53/02 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse
B01D 46/00 - Filtres ou procédés spécialement modifiés pour la séparation de particules dispersées dans des gaz ou des vapeurs
43.
METHOD OF MAPPING SPATIAL DISTRIBUTIONS OF CELLULAR COMPONENTS
This disclosure herein sets forth embodiments for a method for mapping the spatial distribution of one or more cellular components or cellular interactions by using barcodes to identify a cell or cellular component in the one or more cells, localizing, detecting, and mapping the spatial distribution of the one or more cellular components. The disclosure herein sets forth method to allow the mapping of spatial distributions of cellular components both intracellularly or intercellularly.
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p.ex. transfert d’énergie de résonance
Disclosed herein include methods, compositions, and kits suitable for use in sorting a population of cells. In some embodiments, the method comprises flowing a fluid sample comprising a population of cells through a microfluidic channel. The population of cells can be configured to express gas vesicles (GVs) in a context-dependent manner. The expression of GVs within a cell can increase the compressibility (β) and reduce the density (ρ) of said cell, thereby modulating the acoustic contrast (Φ) of said cell relative to the fluid in the microfluidic channel. The method can comprise applying ultrasound to the microfluidic channel. Applying ultrasound can generate acoustic standing wave(s) in the microfluidic channel, thereby positioning pressure antinode(s) in the microfluidic channel.
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein receptor binding domain. Also provided are compositions, methods, and kits for isolating and using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.
C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61P 31/14 - Antiviraux pour le traitement des virus ARN
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
46.
METHODS AND PRINTED INTERFACE FOR ROBOTIC PHYSICOCHEMICAL SENSING
Systems and methods for an electronic skin based robotic system including a robotic interface and a human subject are provided. An e-skin may be applied to the robotic interface. The e-skin applied to the robotic interface may include a plurality of physicochemical sensors. An e-skin may also be applied to the human subject. The e-skin may include electrodes for sensing muscular contractions associated with hand and arm movements as well as electrodes for stimulation. Machine learning techniques may enable decoding of signals to control the robotic hand and arm. The robotic hand and arm may be controlled to approach unknown compounds that may be hazardous. The sensors making up the physicochemical sensors on the e-skin on the robotic hand and arm may include tactile, pressure, temperature, and chemical sensors, as well as other useful sensors. These sensors may enable detection of explosives, organophosphates, pathogenic proteins, and other hazardous compounds.
G01L 1/20 - Mesure des forces ou des contraintes, en général en faisant usage des cellules électrocinétiques, c. à d. des cellules contenant un liquide, dans lesquelles un potentiel électrique est produit ou modifié par l'application d'une contrainte
G01L 5/22 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques pour la mesure de la force appliquée aux organes de commande, p.ex. organes de commande des véhicules, détentes
47.
NON-INVASIVE METHOD AND DEVICE FOR CONTINUOUS SWEAT INDUCTION AND COLLECTION
Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficient collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p.ex. de la grippe
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
Systems and methods for a smart bandage for monitoring and treating wounds are provided herein. The smart bandage may be a smart, wearable, flexible multi-layer substrate that may include a system that can monitor wound characteristics, perform autonomous bioanalysis of wound characteristics to determine wound treatment plans in a non-invasive method, perform drug delivery or antimicrobial agent release to treat and prevent infections, and promote healing by electrical stimulation. The smart bandage may be equipped with a wireless network that can communicate with users, such as patients and medical providers, directly about a patient's wound condition and provide for on-demand wound treatment.
Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased transduction enrichment in the heart and/or skeletal muscle and, in some cases, reduced transduction in the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Gene therapy using the rAAVs is described. Also described are methods of treating diseases and conditions of the heart and/or skeletal muscle.
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir d
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
50.
SYSTEM FOR OPTICALLY ANALYZING A TEST SAMPLE AND METHOD THEREFOR
The present disclosure is directed toward measurement systems capable of optical analysis of a test sample. Embodiments in accordance with the present disclosure include a sample holder having a plurality of projections that extend from a planar surface, where the projections and planar surface collectively define an open sample-collection surface that enables an interrogation signal direct access to the test sample. The projections can be dimensioned and arranged to collectively define a geometric anti-reflection surface that is substantially non-reflective for the interrogation signal even at large angles of incidence. In some embodiments, the sample holder is configured as a reflective element that enables multiple passes of the interrogation signal through the test sample. In some embodiments, the sample holder is configured as a transmissive element. In some embodiments, the projections themselves are reflective.
G01N 21/3577 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p.ex. l'eau polluée
G01J 3/02 - Spectrométrie; Spectrophotométrie; Monochromateurs; Mesure de la couleur - Parties constitutives
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/35 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
The present disclosure provides engineered enzymes and methods for preparing tyrosine and tyrosine analogs from a donor amino acid and phenols in a single step. Also disclosed are methods to engineer enzymes having such 'tyrosine synthase' activity, starting from the beta-subunit of a tryptophan synthase (TrpB).
GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER (Allemagne)
HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (Allemagne)
Inventeur(s)
Plettenburg, Oliver
Ahlbrecht, Christin
Adalian, Dvin
Scherer, Axel
Madero, Xiomara Linnette
Chen, Samson
Jilani, Muhammad Musab
Abrégé
Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.
Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of therapeutic macrophages through a combination of molecular and physical actuation. There are provided, in some embodiments, thermal bioswitches that allow macrophages to sense small changes in temperature and use them as inputs for the actuation of genetic circuits. Genetic circuits capable of inducing expression of a payload upon thermal stimulation are provided. There are provided, in some embodiments, heat-inducible macrophages and methods of using are provided.
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Disclosed herein include methods, compositions, and kits suitable for use in calcium imaging. There are provided, in some embodiments, Ca2+-sensing GvpC proteins. Disclosed herein include Ca2+-sensing gas vesicles (GVs) comprising Ca2+-sensing GvpC proteins. In some embodiments, the Ca2+-sensing GvpC protein is capable of undergoing a first allosteric conformational change upon the Ca2+-binding domain binding Ca2+that causes the Ca2+-sensing GV to change from a GV stiff state to a GV soft state. One or more of the mechanical, acoustic, surface, and magnetic properties of a Ca2+-sensing GV can differ between the GV soft state and the GV stiff state.
Disclosed herein include a photoactivatable vibrational probe, when photoactivated, capable of forming a Raman probe for detection by Raman scattering. In some embodiments, the photoactivatable vibrational probe has a structure of Formula I. Disclosed herein also includes methods of using the photoactivatable vibrational probe for live-cell multiplexed imaging and tracking.
Disclosed herein include methods, compositions, and kits suitable for use in imaging of in situ gene expression. There are provided, in some embodiments, viral vector compositions. Disclosed herein includes a single viral vector comprising one or more gas vesicle assembly (GV A) gene(s) encoding one or more GV A protein(s), and one or more gas vesicle structural (GVS) gene(s) encoding one or more GVS protein(s). The one or more GV A protein(s) and the one or more GVS protein(s) can be capable of forming gas vesicles (GVs) upon expression in a cell.
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C07K 14/195 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
G01N 29/06 - Visualisation de l'intérieur, p.ex. microscopie acoustique
Systems and methods for identifying the components of a long-chain molecule by making electrical measurements from fabricated nanoscale electrodes as the molecule moves down a narrow microfluidic channel. The channel can be along the surface of a chip, through a chip, or both.
Disclosed herein include compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms to the central nervous system, the peripheral nervous system, and/or the lung, with increased specificity and transduction efficiency. Also described include methods of treating various diseases and conditions using the rAAVs.
C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
60.
SYSTEMS AND METHODS FOR GAS-LIQUID CONTACTORS FOR RAPID CARBON CAPTURE
Disclosed herein include methods, compositions, and kits suitable for use in the delivery of polyribonucleotides and circuits. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding cargo RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a sender cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising a fusogen and exported cargo RNA molecule(s).
C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
Disclosed herein include methods, compositions, and kits suitable for use in the measurement of the states of living cells across time. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding reporter RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a reporter cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising exported reporter RNA molecule(s).
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation utilisant la micro-encapsulation, p.ex. utilisant des vésicules liposomiques
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
63.
SYSTEMS AND METHODS FOR NON-INVASIVE PULSE PRESSURE WAVEFORM MEASUREMENT
Systems and methods are provided for a non-invasive high resolution pressure pulse waveform measurement system. The system may include a blood pressure cuff, an air pump to inflate the blood pressure cuff to specific pressure levels, high resolution pressure sensors configured to perform high sensitivity signal acquisition at a specified pressure level, high range pressure sensors configured to measure an absolute reference for the signal and to calibrate the signal, pneumatic tubing connecting the air pump and sensors with the cuff, and a hydrodynamic filter configured as an input to a reference port of the high resolution pressure sensor. The hydrodynamic filter may be configured to transmit only mean pressure by attenuating a selected frequency range of the signal.
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
Systems and methods disclosed herein relate to the detection of irregular particles in a blood flow based on a determined relative speed of a particle suspended in a blood flow and/or other properties of a particle suspended in a blood flow including a particle's relative position within a blood vessel and a particles tendency to cluster with other particles suspended in a blood flow. Based on a determined relative speed and/or other relevant factors, the properties of irregular particles may also be measured, including the size, shape, and frequency of irregular particles in a blood flow. Machine learning techniques may be employed to determine patterns for the behavior of irregular particles suspended in a blood flow. These patterns may correspond to particular health risks and conditions.
Disclosed herein include adeno-associated virus (AAV) acoustic targeting peptides. An AAV comprising the AAV acoustic targeting peptide can exhibit increased transduction at site(s) of focused ultrasound blood-brain barrier opening (FUS-BBBO), increased neuronal tropism, and diminished transduction of peripheral organs. Disclosed herein include recombinant adeno-associated virus (rAAV) comprising an AAV acoustic targeting peptide disclosed herein. Also provided herein include methods of delivering an agent to one or more target brain region(s) of a subject.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
66.
STOICHIOMETRIC EXPRESSION OF MESSENGER POLYCISTRONS
Disclosed herein include methods, compositions, and kits enabling expression of multiple proteins from a single mRNA with a predetermined stoichiometry. There are provided, in some embodiments, nucleic acid compositions comprising a promoter operably linked to a polynucleotide comprising a first nucleic acid unit encoding first unit payload protein(s) and a second nucleic acid unit encoding second unit payload protein(s). The first nucleic acid unit and the second nucleic acid unit can each comprise a 3' engineered translation initiation site (eTIS) comprising a three-nucleotide tunable element immediately upstream of a start codon. The eTIS of each of the first nucleic acid unit and the second nucleic acid unit can be configured to achieve a predetermined stoichiometry of the first unit payload protein(s) and the second unit payload protein(s) in a cell or cell-like environment.
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C12N 15/67 - Méthodes générales pour favoriser l'expression
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation utilisant la micro-encapsulation, p.ex. utilisant des vésicules liposomiques
C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
67.
STAIN-FREE DETECTION OF EMBRYO POLARIZATION USING DEEP LEARNING
Disclosed herein include systems, devices, and methods for detecting embryo polarization from a 2D image generated from a 3D image of an embryo that is not fluorescently labeled using a convolutional neural network (CNN), e.g., deep CNN.
Provided herein are methods and compositions for inhibiting p97, for the treatment of a motor neuron disease in a subject, or a symptom thereof. Upon treatment, the motor neuron disease, or a symptom thereof is reduced in the subject.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/4439 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. oméprazole
A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
A self-deployable antenna and/or antenna array that is made up of one or more antenna elements. Each of the antenna elements has a structural base that supports portions of the antenna and can be positioned between a stored configuration for compaction and a deployed configuration for transmitting. The antenna elements and structural base can be part of a base substrate that provides a base support for the antenna and/or antenna array to be compacted and deployed.
H01Q 1/38 - Forme structurale pour éléments rayonnants, p.ex. cône, spirale, parapluie formés par une couche conductrice sur un support isolant
H01Q 9/28 - Antennes résonnantes avec alimentation intermédiaire entre les extrémités de l'antenne, p.ex. dipôle alimenté par le centre Éléments comportant deux surfaces coniques ayant le même axe et opposées par leurs sommets et alimentés par des lignes de transmission à deux conducteurs
H01Q 19/30 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p.ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant un dispositif secondaire constitué par plusieurs éléments conducteurs sensiblement rectilignes l'élément actif primaire étant alimenté par son centre et sensiblement rectiligne, p.ex. antenne Yagi
Disclosed herein include methods, compositions, and kits suitable for use in vaccination. There are provided, in some embodiments, nucleic acid compositions (e.g., mRNA vaccine, DNA vaccine) comprising a polynucleotide encoding a fusion protein. The fusion protein can comprise an antigenic polypeptide (AP) and an endosomal sorting complex required for transport (ESCRT)-recruiting domain (ERD). A plurality of fusion proteins can be capable of self-assembling into an enveloped nanoparticle (ENP) secreted from a cell in which the fusion proteins are expressed. There are provided, in some embodiments, populations of ENPs.
Disclosed herein are methods for generating an ratiometric symbol for sequential hybridization barcoding for multiplexed Fluorescence In Situ Hybridization (FISH). Also, the disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.
A structure having a tunable modulus of bending (flexibility) composed of interlocking geometric particles arranged such that an external pressure/force causes them to jam together, increasing the stiffness of the overall structure. Methods for creating the external pressure can include the use of an envelope around the structure that can be evacuated of air.
B29C 43/10 - Pressage isostatique, c. à d. en utilisant des organes presseurs non rigides coopérant avec des organes rigides ou des matrices
B29C 64/153 - Procédés de fabrication additive n’utilisant que des matériaux solides utilisant des couches de poudre avec jonction sélective, p.ex. par frittage ou fusion laser sélectif
B29D 24/00 - Fabrication d'objets avec parois creuses
Disclosed herein is a composition for linked amplification tethered with exponential radiance for signal amplification. Also disclosed herein, is a kit for linked amplification tethered with exponential radiance for signal amplification. Also disclosed herein, is a method linked amplification tethered with exponential radiance for signal amplification.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
75.
MASSIVE GENERATION OF CHEMICALLY LIGATEABLE PROBES FOR MULTIPLEXED FISH
Disclosed herein are methods for generating a massive number of chemically ligateable probes for multiplexed Fluorescence In Situ Hybridization (FISH) using a hybrid- primer. Also, the disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.
Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of hydrogel. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficiently collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.
Disclosed herein include compositions and kits comprising recombinant adeno- associated viruses (rAAVs) with tropisms to the central nervous system with increased specificity and transduction efficiency, including endothelial cells of the neurovascular unit. Also described include methods of treating various diseases and conditions using the rAAVs.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
78.
SINGLE CHAIN TRIMER MHC CLASS I NUCLEIC ACIDS AND PROTEINS AND METHODS OF USE
Peptide-major histocompatibility (MHC) Class I nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided.
A coherent imaging system including a transmitter and a receiver. The transmitter includes a coherent source and a power splitter for splitting the electromagnetic radiation into a reference and a signal beam. The receiver includes an image forming device and an array of pixels. Each of the pixels include means for collecting at least a portion of the signal beam imaged on the pixel by an image forming device, as a collected signal; means for splitting the collected signal into a plurality of collected signals each having different phase shifts; means for mixing each of the collected signals with the reference beam so as to form a plurality of mixed signals; and means for detecting the mixed signals and outputting a plurality of output electrical signals in response to the mixed signals.
G01R 33/54 - Systèmes de traitement du signal, p.ex. utilisant des séquences d'impulsions
G01R 33/34 - Systèmes d'excitation ou de détection, p.ex. utilisant des signaux radiofréquence - Détails de structure, p.ex. résonateurs
G01R 33/36 - Systèmes d'excitation ou de détection, p.ex. utilisant des signaux radiofréquence - Détails électriques, p.ex. adaptations ou couplage de la bobine au récepteur
G01R 25/04 - Dispositions pour procéder aux mesures de l'angle de phase entre une tension et un courant ou entre des tensions ou des courants faisant intervenir le réglage d'un déphaseur pour produire une différence de phase prédéterminée, p.ex. une différence nulle
80.
TILED POROUS ARCHITECTED COMPOSITIONS, METHODS OF THEIR MAKING
Provided herein are compositions having a porous, architected three-dimensional geometry that are tiled to achieve increased surface area and/or volume. The tiled compositions include a plurality of tiles having seams where one of the plurality of tiles contacts an adjacent tile. Also provided herein are methods and systems for making the compositions.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/236 - Moyens d’entraînement pour un mouvement dans une direction dans le plan d’une couche
B29C 64/282 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p.ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED] du même type, p.ex. utilisant des niveaux d’énergie différents
The present disclosure provides methods for analyzing genomic structures by diffraction limited locus imaging and nucleic acid block coding. The methods allow efficient and scalable imaging, which can be applied to multiplexed RNA/DNA fluorescence in situ hybridization (FISH).
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. indolizine, bêta-carboline
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p.ex. ticlopidine
A61K 31/428 - Thiazoles condensés avec des carbocycles
A61K 31/429 - Thiazoles condensés avec des systèmes hétérocycliques
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. indolizine, bêta-carboline
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p.ex. ticlopidine
A61K 31/428 - Thiazoles condensés avec des carbocycles
A61K 31/429 - Thiazoles condensés avec des systèmes hétérocycliques
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
Systems and methods for measuring flow velocity of a fluid mixture in a lateral section of an oil/gas/water well with a dual beam laser doppler velocimetry (LVD) based flow sensor are presented. According to one aspect, the flow velocity is measured by tracking movement of particles and/or features in the fluid mixture while traversing an interference pattern generated by the intersection of two separate coherent beams that are perpendicular to a direction of the flow. Flow velocity is derived based on a time it takes the particles to traverse consecutive fringes of the interference pattern as indicated by intensity peaks detected at the photodetector. The LDV-based flow sensor may be rotatable to measure flow velocities at different angular positions of a pipe in a lateral section of an oil well, rotation provided by rotation of an element of a mobile vessel to which the flow sensor is rigidly coupled.
G01P 5/26 - Mesure de la vitesse des fluides, p.ex. d'un courant atmosphérique; Mesure de la vitesse de corps, p.ex. navires, aéronefs, par rapport à des fluides en mesurant l'influence directe du courant de fluide sur les propriétés d'une onde optique de détection
G01P 5/20 - Mesure de la vitesse des fluides, p.ex. d'un courant atmosphérique; Mesure de la vitesse de corps, p.ex. navires, aéronefs, par rapport à des fluides en mesurant le temps mis par le fluide à parcourir une distance déterminée en utilisant des particules entraînées par un courant de fluide
G01F 1/7086 - Mesure du temps de parcours d'une distance déterminée utilisant des dispositions de détection optique
G01F 1/712 - Mesure du temps de parcours d'une distance déterminée utilisant des moyens de détection à autocorrélation ou à intercorrélation
G01F 1/74 - Dispositifs pour la mesure du débit d'un matériau fluide ou du débit d'un matériau solide fluent en suspension dans un autre fluide
85.
SYSTEM FOR MEASURING MULTIPHASE FLOW IN DOWNHOLE CONDITIONS AND FLOW REGIMES
Systems and methods for measuring multiphase flow of a fluid mixture in a downhole pipe of an oil/gas/water well are presented. According to one aspect, time-series measurement of the flow velocity and composition at a plurality of discrete azimuths of the pipe are measured. Measured time-correlated velocity and composition data are used to identify fluid components present in the pipe and estimate cross-sectional area and velocity of each of the fluid components. According to another aspect, pressure and temperature at the downhole pipe are measured, and used to calculate the mass density of each fluid component. For each of the fluid components, the cross-sectional area, velocity, and mass density are used to generate a corresponding mass flow rate. An algorithm with a set of parameters tuned to specific flow regimes is used to map the sensed data from the time-series measurements into the mass flow rate of each fluid component.
E21B 47/00 - Relevés dans les trous de forage ou dans les puits
G01F 1/7086 - Mesure du temps de parcours d'une distance déterminée utilisant des dispositions de détection optique
G01F 1/712 - Mesure du temps de parcours d'une distance déterminée utilisant des moyens de détection à autocorrélation ou à intercorrélation
G01F 1/74 - Dispositifs pour la mesure du débit d'un matériau fluide ou du débit d'un matériau solide fluent en suspension dans un autre fluide
G01N 30/00 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p.ex. la chromatographie
86.
ACOUSTIC REMOTE CONTROL OF MICROBIAL IMMUNOTHERAPY
Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of probiotic cells. There are provided, in some embodiments, thermal bioswitches that allow probiotic cells to sense small changes in temperature and use them as inputs for the actuation of genetic circuits. Genetic circuits capable of inducing expression of a payload upon thermal stimulation are provided. Thermally actuated probiotic cells and methods of use for the treatment of diseases or disorders are also provided.
Systems and methods for driving and steering of a robot, or mobile vessel, for operation in a downhole pipe of an oil/gas/water well are presented. According to one aspect, the mobile vessel includes a plurality of wheels arranged outwardly from the mobile vessel so that each wheel may contact the inner wall of the casing. According to another aspect, the plurality of wheels may include respective wheel-centerlines that intersect the centerline of the casing that is at an offset from a centerline of the mobile vessel. The plurality of wheels includes at least two drive wheels and at least one passive wheel. According to a further aspect, the drive wheels are configured to rotate about their respective wheel-centerlines to steer the mobile vessel during traversal of the casing. In one case, the mobile vessel includes two drive and steering wheels and one passive wheel.
E21B 23/00 - Appareils pour déplacer, mettre en place, verrouiller, libérer ou retirer, les outils, les packers ou autres éléments dans les trous de forage
F16L 55/30 - Caractéristiques de structure des moyens de propulsion, p.ex. traction par des câbles
88.
INTERPLANETARY NETWORKS FOR SPACE INTERNET AND SPACE POSITIONING
Interplanetary networks for space internet and space positioning are presented. The described networks deploy spacecraft swarms along the solar system to form a science and communications platform. The disclosed network nodes are placed around planetary Lagrange points. Creation of optical synthetic apertures using smallsat swarms for inter- and intranet communications is further described. Exemplary subnetworks such as the cislunar network are also presented.
G01S 19/02 - Systèmes de positionnement par satellite à radiophares émettant des messages horodatés, p.ex. GPS [Système de positionnement global], GLONASS [Système global de navigation par satellite] ou GALILEO - Détails des installations de contrôle terrestres ou spatiales
H04B 10/118 - Dispositions spécifiques à la transmission en espace libre, c. à d. dans l’air ou le vide spécialement adaptées aux communications par satellite
89.
SYSTEMS AND METHODS FOR EFFICIENT CRUISE AND HOVER IN VTOL
A system of a multi-rotor aircraft that capitalizes on the advantages of fixed wing elements combined with rotary wing structures. The fixed wing elements can help to generate lift once the aircraft is airborne and can thus reduce the need for larger lifting rotors which can allow for longer flight times and distances. Additionally, the systems disclosed herein take advantage of a partial in-wing configuration with a number of rotors to reduce the overall footprint of the vehicle while maintaining the flight efficiency that comes with combining features of fixed and rotary wing elements, and increasing operator safety by shrouding rotating parts. The unique configurations allow for a decoupling of the pitch, yaw and roll authority to reduce the complexity in control systems and improve the flight efficiency of the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque.
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (USA)
CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (USA)
Inventeur(s)
Friedman, Rick A.
Boussaty, Ely
Hoelz, Andre
Olson, Steven
Shaw, Reuben
Abrégé
The present disclosure provides compositions and methods for prevention or treatment of hearing loss. In some examples, a composition for preventing or treating hearing loss comprises at least one compound that activates AMPK in at least one hair cell.
A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. indolizine, bêta-carboline
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
91.
NEURAL-NETWORK-OPTIMIZED DEGREE-SPECIFIC WEIGHTS FOR LDPC MINSUM DECODING
Neural Normalized MinSum (N-NMS) decoding for improving frame error rate (FER) performance on linear block codes over conventional normalized MinSum (NMS). Dynamic multiplicative weights are assigned to each check-to-variable message in each iteration to efficiently provide training parameters of N-NMS that support N-NMS for longer block lengths. Embodiment are described for neural two-dimensional normalized MinSum (N-2D-NMS) decoders requiring fewer training parameters. The N-2D-NMS approaches for example use the same weight for edges with the same check and/or variable node degree. Simulation results indicate that that this LDPC decoding performs similarly to previous techniques while substantially reducing the amount of training necessary.
H03M 13/11 - Détection d'erreurs ou correction d'erreurs transmises par redondance dans la représentation des données, c.à d. mots de code contenant plus de chiffres que les mots source utilisant un codage par blocs, c.à d. un nombre prédéterminé de bits de contrôle ajouté à un nombre prédéterminé de bits d'information utilisant plusieurs bits de parité
H03M 13/00 - Codage, décodage ou conversion de code pour détecter ou corriger des erreurs; Hypothèses de base sur la théorie du codage; Limites de codage; Méthodes d'évaluation de la probabilité d'erreur; Modèles de canaux; Simulation ou test des codes
222-content feed streams, including air, and method of making and using the same. In some embodiments, the compositions comprise zinc-ion-doped zeolites having AEI, AFX, or CHA topologies.
Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.
Method for detecting and barcoding the molecular changes occurring in two or more samples upon exposure to different stimuli. This disclosure herein sets for methods that allow a targeted transcriptome-imaging approach that records both gene-expression and spatial context within microscale assemblies at a single-cell and molecule resolution on biological samples. This disclosure herein sets for methods that allows the application to a variety of biological samples for the study of cellular processes, growth, and interactions between biological samples.
A61K 31/444 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. amrinone
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p.ex. œstrane, œstradiol substitués en position 17 alpha, p.ex. mestranol, noréthandrolone
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/74 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des hormones
96.
ZINC-CONTAINING ZEOLITES DESICCANTS, AND METHODS OF USING THE SAME
The present disclosure is directed to metal ion-containing zeolific compositions, preferably transition metal ion-containing, more preferably zinc ion containing zeolitic compositions, that are useful for reversibly scavenging water from humid gaseous feed streams, including air, and method of making and using the same. In some embodiments, the compositions comprise zinc-ion-doped zeolites have LTA, FAU, or EMT topologies.
Provided herein is an antibiotic susceptibility and related compositions, methods and systems based on nucleic acid detection based on detected intracellular and extracellular nucleic acid from a same sample, which allows determination of antibiotic susceptibility of microorganisms as well as the diagnosis and/or treatment of related infections in individuals.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
Nucleic acids provide a versatile platform for engineering synthetic biology in medicine, science, agriculture, and energy. Degradation of nucleic acid molecules poses an engineering challenge. Nucleic acid protective elements (PELs) protect chemically synthesized or expressed nucleic acid molecules from degradation. PELs are derived from all or part of a viral xrRNA sequence and/or structural motif, or from rationally designed sequences and/or structural motifs, or they are engineered using directed evolution. PELs may also comprise a mixture of biologically derived, rationally designed sequence and/or structural motifs, and/or sequences and/or structural motifs engineered by directed evolution. PELs significantly enhance the performance of nucleic acids, protecting the regulatory and/or structural elements from degradation to increase regulatory dynamic range, fractional dynamic range, fold-change, and/or other performance metrics. PELs are used in applications including therapeutics, diagnostics, biological research tools, vaccines, crop protection, molecular manufacturing, sustainable energy production, and other areas involving nucleic acids.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
99.
ALLOSTERIC CONDITIONAL GUIDE RNAS FOR CELL-SELECTIVE REGULATION OF CRISPR/CAS
Disclosed herein are allosteric conditional gRNA (cgRNA) mechanisms for both ON->OFF logic (conditional inactivation by an RNA trigger) and OFF->ON logic (conditional activation by an RNA trigger). Allosteric cgRNAs enable restriction of CRISPR/Cas function to a desired cell type, tissue, organ, or disease state. Allosteric cgRNAs provide a versatile platform for cell-selective and tissue-selective research tools, biotechnologies, diagnostics, and therapeutics.
A system and method for controlling a multi-rotor aircraft that implements the unconventional use of different sized rotors. The different sized rotors than the main rotors tend to generate an unbalanced torque and pitch on the aircraft that effectively decouples the pitch and yaw control from the main rotors. The atypical design tends to lend itself to improved control capabilities and simplified control systems. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.
brevets
