There is provided a method of forming an edge-functionalised 2D material, comprising mixing the 2D material with a solvent at a first pre-determined temperature, adding an oxidising agent and a multifunctional molecule, adjusting the temperature to a second pre-determined temperature, adjusting the temperature to a third pre-determined temperature and adding a quenching agent to form a suspension, wherein the suspension comprises the edge-functionalised 2D material.
Disclosed is a time-to-digital converter (TDC)-based device comprising a crossbar array for generating a current, a current-controlled delay line 104 for converting the current received from the crossbar array into a time pulse, and a TDC circuit 106 for measuring and converting the time pulse into digital output.
G04F 10/00 - Apparatus for measuring unknown time intervals by electric means
G04F 10/10 - Apparatus for measuring unknown time intervals by electric means by measuring electric or magnetic quantities changing in proportion to time
3.
FORCE FEEDBACK ACTUATOR APPARATUS AND METHOD OF OPERATION
The present invention discloses force feedback actuators (100, 100a, 100b, 200, 200a, 200b, 300) to provide blunt force, point-impact force, amplified force or moving-force sensation. Each force feedback actuator is made up of a base layer (102), an internal cavity (106, 106a, 206) in fluid communication with a port (104), a flange ring (110, 110b) and a skin layer (140, 140b, 240). The internal cavity (106, 106a, 206) forms an air-tight chamber with the port (104) and a tubing (T) supplying or releasing fluid pressure through the port (104). Disposed in the internal cavity (106, 106a, 206) is a preformed bladder (120) or a bladder membrane (120a), which when actuated with a fluid pressure, causes the skin layer (140, 140b, 240) to bulge outwardly to simulate force sensations. In some embodiments, a top surface of the flange ring (110, 110b) is formed with crenellations (114) and associated petal members (112, 112b). These force feedback actuators may be located inside a wearable apparel.
Mmomoommm); and calculating, using the processing device, a Mean Squared Error (MSE) lack of fit (d) of the shape fitting, wherein the calculated MSE lack of fit (d) is used to predict a type of the cardiac disease (y) in the subject.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
B65D 1/00 - Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations p
6.
ANTI-INFLAMMATORY RED BLOOD CELL EXTRACELLULAR VESICLES (RBCEVS)
The present disclosure describes anti-inflammatory properties of red blood cell extracellular vesicles, e.g., as mediated by heme, hemoglobin and/or phosphatidylserine content. The present disclosure describes technologies useful for the treatment of inflammatory diseases, disorders, or conditions (e.g., atherosclerosis).
A61K 35/12 - Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
7.
AN APPARATUS, SYSTEM, AND METHOD FOR HEAT EXCHANGE
This invention provides an apparatus for heat exchange comprising a plurality of fins, and a heat transfer coil in the form of a plurality of oblong sectional tubes being arranged in a single array. The fins are arranged along a longitudinal portion of the oblong sectional tubes substantially perpendicularly for guiding incoming convective fluid towards all the oblong sectional tubes for heat exchange to be performed thereupon. Furthermore, the oblong sectional tubes of the heat transfer coil each has a substantially rectangular cross-section with round edges, or oval or elliptical cross-section, and are operable to be installed with a tilt angle for them to be tilted with a major axis of the oblong sectional tube being in respect to a direction of the incoming convective fluid flowing through the heat transfer coil. A related system and method involving the apparatus are further described.
F28F 1/02 - Tubular elements of cross-section which is non-circular
F28F 1/32 - Tubular elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses the means being only outside the tubular element and extending transversely the means having portions engaging further tubular elements
F28D 1/053 - Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or mo with the heat-exchange conduits immersed in the body of fluid with tubular conduits the conduits being straight
Provided is a method for coupling flavonoid-containing compounds to provide flavonoid dimers, trimers and oligomers. The method comprises contacting a flavonoid-containing compound with base in the presence of air. Flavonoid dimers, trimers and oligomers may also be useful in the treatment of diseases, such as fungal infections and diseases associated with starch hydrolase.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
C07D 311/30 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
C07D 311/36 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
Wirelessly powered photodynamic therapy devices are disclosed and systems and methods using such devices are also disclosed. In an embodiment, a photodynamic therapy system comprises: an implantable illumination device comprising a light source configured to emit light having a spectrum which overlaps with an absorption peak of an absorption target and a receiver antenna coupled to the light source and configured to extract power from a radiofrequency power signal incident on the implantable illumination device; and a transmitter comprising an antenna, a powering module configured to generate a drive signal which causes the antenna to generate the radiofrequency power signal, and a dosimetry module coupled to the antenna and configured to detect a radiofrequency signal backscattered from the implantable illumination device and determine an indication of the power extracted by the implantable illumination device from the radiofrequency signal backscattered from the implantable illumination device.
A MICROCARRIER, A METHOD OF MAKING A MICROCARRIER, A SYSTEM FOR PRODUCING A CELL CULTURED FOOD PRODUCT AND A METHOD OF PRODUCING A CELL CULTURED FOOD PRODUCT
There is provided a microcarrier, a method of making a microcarrier, a system for producing a cell cultured food product and a method of producing a cell cultured food product, the microcarrier comprising, a core particle; and a coating layer disposed on a surface of the core particle; wherein the core particle and coating layer comprise one or more materials derived from plant-based sources.
The present disclosure concerns a micro-flow system for synthesis of a compound, comprising a tubing reactor configured to flow a reactant within its lumen thereof, an actuator for regulating the flow of the reactant in the lumen and a heterogeneous catalyst in fluid communication with the lumen. The present disclosure also concerns a method of micro-flow synthesising a compound using the micro-flow system.
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 8/08 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with moving particles
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
Disclosed herein is a method and an apparatus for producing graphene. The method comprises maintaining a molten salt bath in a carbonaceous environment; immersing a cathode made of copper, an anode and a reference electrode of an electrode system in the molten salt bath; and applying a negative potential at the cathode to form graphene at the cathode. The apparatus for producing graphene, comprises a cell structure including a molten salt bath maintained in a carbonaceous environment; and an electrode system having a cathode made of copper, an anode and a reference electrode immersed in the molten salt bath, wherein the electrode system is configured to provide a negative potential at the cathode for forming graphene at the cathode.
Disclosed herein is a carbon nanotube, a method of producing carbon nanotubes and an apparatus for producing carbon nanotubes. The method comprises maintaining a molten salt bath in a carbonaceous environment; immersing an iron-based cathode, an anode and a reference electrode of an electrode system in the molten salt bath; and applying a negative potential at the iron-based cathode to form the carbon nanotubes at the cathode. The apparatus for producing carbon nanotubes, comprises a molten salt bath maintained in a carbonaceous environment; and an electrode system having an iron-based cathode, an anode and a reference electrode immersed in the molten salt bath, wherein applying a negative potential at the iron- based cathode forms carbon nanotubes at the cathode. The carbon nanotube includes an iron core shell structure with an iron nucleation tip.
15.
MICROBIAL CONSORTIUM FOR PLANT GROWTH AND METHOD FOR PREPARING THE SAME
The present disclosure relates to a microbial consortium for plant growth and a method for preparing the microbial consortium The microbial consortium comprises at least two microbial strains, wherein each of the at least two microbial strains has at least a plant growth-promoting genetic element; and wherein one of the at least two microbial strains forms a syntrophic relationship with the remaining of the at least two microbial strains.
Ultra-low voltage AlGaN/GaN ultraviolet (UV) photodetectors (21) are provided. The UV photodetector (21) comprises an anode electrode (17), fin trenches (15) filled with a Schottky contact ITO layer to form fin-shaped cathode electrodes (19), and partial sidewall oxide passivation (16) around the fin trenches (15) split an intrinsic 2DEG plane (11) located in the GaN layer into islands; the 2DEG plane is isolated from the cathode electrodes (19) and transformed into field plates when biased by the anode electrode (17). Owing to the intrinsic polarization field and fin-shaped cathode electrodes (19), photo-carriers collections are effected at a bias voltage as low as about 200 mV, with a 365-nm photocurrent-to-dark current ratio above 105 and a peak UV responsivity around 103. As a result, enhanced frequency response is exhibited up to about 1 kHz on 365-nm UV switching. The photodetector (21) is suitable for future ultra-low voltage III-V circuits integration.
The present invention relates to methods modifying cell surface markers of red blood cells (RBCs) and uses of the same. In particular, the method comprises contacting an RBC with a peptide in the presence of a ligase, under suitable conditions and for sufficient time to allow ligation of the peptide to the RBC to form an RBC-peptide conjugate. In one embodiment, the ligase is OaAEPI ligase. The RBC-peptide conjugate may be further contacted with an effector molecule under suitable conditions and for sufficient time for conjugation of the effector molecule to the RBC-peptide to form an RBC-peptide-effector molecule conjugate.
Disclosed herein is a composite material comprising: a plurality of water-stable metal-organic frameworks, each having a plurality of porous cavities; and a temperature-sensitive polymeric material in the form of polymer chains, wherein the polymer chains of the temperature-sensitive polymeric material are formed at least partly within the porous cavities of the plurality of water-stable metal-organic frameworks. Also disclosed herein is the use of said composite material for adsorption and release of water.
B01D 53/28 - Selection of materials for use as drying agents
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
SINGAPORE HEALTH SERVICES PTE LTD (Singapore)
Inventor
Yao, Xiaosai
Hong, Jing Han
Mangalvedhekar, Amrita Mandar
Ng, Shu Wen Michelle
Teh, Bin Tean
Abstract
The present invention relates, in general terms, to cancer biomarkers. Disclosed herein are methods of identifying cancers that are suitable for NF-κB inhibition therapy, and methods of selecting subjects for the same, comprising detecting an indicator that is indicative of a level or activity of Protein polybromo-1 (PB1) in a sample obtained from the subject, wherein the cancer is identified as being likely to be responsive to the inhibitor of NF-κB signalling when the level or activity of PB1 indicated by the indicator corresponds to an absence or decreased level or activity of PB1 in the sample as compared to a control.
The invention relates generally to virology. In particular, the specification teaches a method of attenuating a flavivirus, by modifying the viral genome to have a protein coding sequence having one or more synonymous codons as compared to the protein coding sequence of a parent virus, wherein the modified viral genome is associated with increased protein expression as compared to the viral genome of the parent virus in a mammalian host. Provided herein is also a modified flavivirus as defined herein.
A metal-organic framework membrane There is provided an amorphous monolithic metal-organic framework membrane which is free of grain boundaries and grain junctions. There is also provided a method of forming the same.
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
22.
COVALENT ORGANIC FRAMEWORKS USED AS SOLID PROTON-CONDUCTING MEMBRANE
Disclosed herein is a proton-conducting membrane for a proton exchange membrane fuel cell comprising a non-proton conducting covalent organic framework comprising a plurality of imine linkages and a plurality of pores each having an interior wall, and a plurality of phosphoric acid molecules disposed within the plurality of pores. Also disclosed herein is a proton exchange membrane fuel cell comprising a proton-conducting membrane as aforementioned.
C08G 83/00 - Macromolecular compounds not provided for in groups
H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]
This invention provides a slurry for use in additive manufacturing, comprising a first constituent, being a photomonomer or photopolymer, a second constituent, being a dispersant, a third constituent, being sinterable particles, and a fourth constituent, being a photoinitiator. The second constituent adsorbs to surfaces of the third constituent through at least one mode of adsorption. Further provided is a method for additive manufacturing involving the slurry.
B28B 1/00 - Producing shaped articles from the material
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
Disclosed herein an optical media, a method of making an optical media and a photovoltaic window. The optical media includes a matrix and luminescent phosphors dispersed in the matrix. The luminescent phosphors include at least one of luminescent inorganic phosphors and quantum dot nanocrystals. The optical media may be made into a thin film attached to a window glass. The luminescent phosphors emit excitation light under irradiation of the incident light, which is converted into electrical energy through the photovoltaic cells. The photovoltaic window includes a light-transmitting substrate, an optical media and a first photovoltaic cell. The optical media is attached to the front/rear main surface of the light-transmitting substrate. The first photovoltaic cell is attached to the side surface of the light-transmitting substrate. The optical media receives the incident light projected on the light-transmitting substrate and generates excitation light which is projected on the first photovoltaic cell and converted into electrical energy.
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
A method of using a quantum random number generator, QRNG, for security applications, a system for security applications, and a user device for a system for security applications. The method comprises the steps of generating one or more quantum keys using the QRNG; storing, using a secure network, corresponding sets of the quantum keys in a server located at a controlled access location and in a quantum key token, QKT, for a user, respectively; and using the corresponding sets of quantum keys for secure transmission between the server and a user device comprising the QKT when outside the secure network or for access control to the controlled access location.
A thin-film-composite hollow-fiber membrane includes a phase-inversion layer, which is in the form of a hollow fiber, and an active layer coated on the phase-inversion layer. The active layer selectively allows passage of water molecules but rejects at least some dissolved ions. The thin-film-composite hollow-fiber membrane can have an internal burst pressure of at least 4 MPa. In a method for forming the membrane, the polymer concentration in the spinning dope from which the hollow-fiber substrate is formed can have a polymer concentration no greater than 5% below the critical concentration.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
A recombinant cell of Saccharomyces cerevisiae that includes in its genome nucleic acids encoding cannabinoid biosynthetic pathway genes. A cannabinoid is produced by the recombinant cell in the presence of a cannabinoid precursor substrate and at least one of the cannabinoid biosynthetic pathway genes is from an organism other than Cannabis sativa, wherein the at least one of the cannabinoid biosynthetic pathway genes encodes a prenyltransferase. In an embodiment, the prenyltransferase is NphB from Streptomyces sp. having the amino acid sequence of any one of SEQ ID NOs: 8-11. Also disclosed is a method for producing a cannabinoid with the recombinant cell and the cannabinoid precursor substrate.
NATIONAL UNIVERSITY OF SINGAPORE (CHONGQING) RESEARCH INSTITUTE (China)
Inventor
Lu, Li
Wang, Yumei
Yi, Qiang
Abstract
Provided are a flame-retardant composite electrolyte, a manufacturing method, and a high-safety flame-retardant lithium battery manufactured from the flame-retardant composite electrolyte. The flame-retardant composite electrolyte comprises a porous organic-inorganic composite film and a flame-retardant gel electrolyte. The porous organic-inorganic composite film is prepared by electrospinning an organic-inorganic composite solution precursor and carrying out subsequent high-temperature heat treatment or hot pressing treatment. The flame-retardant gel electrolyte is cured/polymerized in situ in pores of the organic-inorganic composite film to prepare the flame-retardant composite electrolyte. The composite electrolyte has high thermal stability, a high electrochemical stability window (4.52 V Vs. Li/Li+, room temperature), and high ionic conductivity (~10-3 S/cm, room temperature). The high-safety flame-retardant lithium battery manufactured from the flame-retardant composite electrolyte also exhibits excellent cycle performance.
Disclosed herein is a method of separating hydrocarbons from each other, the method comprising the steps of (a) providing a metal organic framework (MOF) formed from a metal ion and/or metal cluster and an organic linker, and (b) passing a fluid stream comprising a mixture of hydrocarbons over the MOF to cause separation of the hydrocarbons. Also disclosed herein is a method of separating alkanes comprising the steps of (a) providing a MOF comprising nickel as the metal ion and/or metal cluster and formic acid as the linker, and (b) passing a fluid stream comprising a mixture of alkanes over the MOF to cause separation of the alkanes.
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
C07C 7/12 - Purification, separation or stabilisation of hydrocarbons; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
31.
RHIZOMUCOR MIEHEI LIPASE TOWARDS AMIDE BOND FORMATION FOR THE SYNTHESIS OF MEDIUM TO LONG CHAIN N-ACYL GLYCINES IN AQUEOUS MEDIA
Described herein are lipase variants of a Rhizomucor Miehei Lipase. The lipase variants may be used to prepare medium to long chain N-acyl glcyines. The variants may have a parent sequence of SEQ ID NO: 3; and a D156 substitution and/or a L258 substitution, wherein the D156 substitution is selected from the group consisting of serine (S), glycine (G), glutamic acid (E), and threonine (T), wherein if the D156 substitution is glycine, the lipase variant comprises at least one other substitution, and the L258 substitution is selected from the group consisting of lysine (K), arginine (R), glutamine (Q), asparagine (N), histidine (H), and serine (S). The variants may have a parent sequence of SEQ ID NO: 3; and at least one substitution of the following amino acids: D156, L258. L267, V254, L255, N264, T265, S83, S84, W88, R30, R86, S56, L58, and 1I59.
The present invention concerns the cosmetic field, and especially cosmetic uses of at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof, or a conditioned culture medium obtained from at least one microorganism which is able to produce such short chain fatty acid(s), as antidandruff agent, for preventing and/or treating desquamative disorders of the skin associated with the excessive proliferation of yeasts of the Malassezia genus on the skin and for maintaining and/or restoring at a normal level, the ecoflora of the skin and especially by preventing excessive colonization of the skin by Malassezia genus and/or by mediating growth of Cutibacterium acnes.
A61Q 17/00 - Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A method for producing a cannabinoid precursor by contacting a substrate and geranyl pyrophosphate or farnesyl pyrophosphate with an NphB orthologue. The NphB orthologue is from an organism other than Cannabis sativa, and the substrate can be 2,4-dihydroxy-6-pentylbenzoic acid or 2,4-dihydroxy-6-propylbenzoic acid. Also disclosed is a recombinant cell of Yarrowia lipolytica, carrying in its genome a nucleic acid encoding an NphB orthologue from an organism other than Cannabis sativa such that the NphB orthologue is expressed in the recombinant cell.
The present invention relates to a process for the separation of propylene from a gas mixture (GM) comprising propylene and propane by means of a membrane (M) comprising a polyarylene ether sulfone polymer (P) prepared by converting a reaction mixture (RG) comprising at least one aromatic dihalogen sulfone and at least one dihydroxy component comprising trimethylhydroquinone.
The present disclosure provides methods and devices for separation of motile sperm. A method of separating motile sperm comprises: introducing a fluid sample comprising motile sperm to an inlet portion of a microfluidic device; and causing the fluid sample to flow through a separation portion of the microfluidic device at a flow velocity within a rheotaxis range such that motile sperm in the sample undergo rheotaxis and remain in the separation whereas a part of the fluid sample flows out of the separation zone through an outlet portion of the microfluidic device.
A method for producing a cannabinoid by contacting cannabigerolic acid with a cannabinoid synthase orthologue. The cannabinoid synthase orthologue is from an organism other than Cannabis sativa. Also disclosed is a recombinant cell of Saccharomyces cerevisiae or Pichia pastoris that includes in its genome a nucleic acid encoding the above cannabinoid synthase orthologue. The cannabinoid synthase orthologue is expressed in the recombinant cell in an active form.
The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA; and a method for killing cells or treating a disease using said tsRNA.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Embedded memory structures and methods where an array of bitcells is interconnected by a plurality of bitlines and wordlines, each bitcell comprising a transistor connected to one of the wordlines and one of the bitlines. A TRNG circuit, peripheral to the array of bitcells, sets transistors connected to the one or more of the bitlines to an off state, determines a time interval between different crossing thresholds in a voltage discharge in the bitlines, and digitizes the time interval into bits of an TRNG output. A PUF circuit. peripheral to the array of bitcells, sets a pair of transistors connected to the pair of bitlines and the same wordline to an underdriven state, determines respective times of the transistors of the pair crossing a threshold in a voltage discharge in the pair of bitlines, and digitizes a time difference into an n-bit PUF output.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
40.
SURFACE TREATMENT METHOD FOR FORMING A PASSIVATED CONTACT OF A SOLAR CELL
Surface treatment method for forming a passivated contact of a solar cell A surface treatment method for forming a passivated contact of a solar cell 100 is described. In an embodiment, the solar cell 100 comprises a silicon layer 102 having a textured surface, and the method comprises: (i) etching a portion of the silicon layer 102 using a first etchant to reduce surface protrusions of the textured surface and to provide an intermediate surface of the silicon layer 102; and (ii) etching the intermediate surface of the silicon layer 102 using a second etchant to form a treated surface of the silicon layer 102 having a desired roughness for forming the passivated contact of the solar cell, the second etchant having a slower etching rate on silicon than that of the first etchant.
There is provided a material comprising a plurality of geminal metal atom pairs supported on a polymeric carrier, and a method of preparing said material. In a particular embodiment, the material comprises a plurality of copper atom pairs supported on a polymeric carbon nitride (PCN) carrier. There is also provided a catalyst comprising said material, and a method of catalyzing coupling reactions.
The present invention relates to live attenuated flaviviruses and immunogenic composition of flaviviruses. The disclosure specifically relates to live attenuated Dengue- 1, Dengue-2, Dengue-3, and Dengue-4 viruses comprising 11 14T mutation in NS2B wherein the viruses have an increased immunogenicity, an increased rate of replication and decreased plaque size as compared to the wildtype viruses. It further discloses the generation of attenuated flaviviruses comprising NS2B- 11 14T with a mutation in amino acid 29 in prM and/or a mutation in amino acid 53 in NS1. It also relates to the use of said viruses for treatment of flavivirus infection.
The present invention relates to an engineered disulphide-linked ferritin assembly comprising at least one modified ferritin subunit, wherein the at least one modified ferritin subunit comprises the amino acid sequence set forth in SEQ ID NO: 1, and comprises; i) a F116H substitution, and zero or more amino acid substitutions at one or more positions selected from the group comprising E65, E128, E131, and D138 of SEQ ID NO: 1, and ii) a Cys substitution at two or more positions selected from the group comprising G37, L53, R66, G67, A74, A117 and A152 of SEQ ID NO: 1. The present invention also relates to its uses and manufacture.
The present invention describes a dishwasher handling apparatus (100). Dishware (10,11,12,13) made of non-magnetic material and equipped with a ferrous member (20) embedded or attached at a base, or a ferritic dishware (14) can be used with this apparatus. The apparatus (100) includes dishware handling apparatuses (101,101a,201) located upstream and downstream of a dishwasher (30). Each upstream or downstream dishware handling apparatuses (101,101a,201) include a conveyor elevator (130,230) that is operable to dock with a multi-storey shelf (110,210). Each of the multi-storey shelf has a level being equipped with a powered conveyor (120,220), on which vertical stacks (105) of dirty dishware are handled for cleaning or vertical stacks (107) of cleaned dishware are stored up after being cleaned. The upstream dishware handling apparatus (101a) further includes a rinsing robot (150). End-effectors (300,300-1,300-2,300-3) and handling robots (170,170a,180,280) are used to transfer dishware between component apparatuses or stations.
The present disclosure relates to a method of synthesising hexamethylenediamine and adipic acid. The method comprises homocoupling of acrylamide under conditions including using oxalic acid as a reductant and irradiating a reaction mixture comprising acrylamide with light from a light source to obtain an amide substrate, wherein the method further comprises a pathway 1 and a pathway 2 for forming hexamethylenediamine and adipic acid, respectively using the amide substrate.
C07C 2/74 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition with simultaneous hydrogenation
C07C 231/08 - Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
C07C 231/14 - Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
C07C 209/50 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
C07C 51/06 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid amides
Systems and methods for federated scoring by a plurality of nodes, wherein each node comprises sensitive data based on which a first set of scoring model coefficients generated. The first set of scoring model coefficients are broadcast to rest of the nodes and at least one node generates a federated scoring model based on the received contributory intermediate statistics and its respective first set of scoring model coefficients.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
The present disclosure generally relates to a robotic gripper comprising: a body; a plurality of displacement mechanisms; a plurality of finger modules removably connected or connectable to the body, such that each finger module engages with a respective displacement mechanism; each finger module comprising a finger actuator cooperative with the other finger actuators for gripping an object; and each displacement mechanism is configured for moving the respective finger module to adjust its arrangement on the body, thereby configuring the robotic gripper for gripping the object.
The invention relates to an artificial antigen-presenting cell (aAPC) comprising at least one immune stimulatory ligand and co-stimulatory ligands comprising or consisting of CD86, CD70 and CD137L, methods of preparing an aAPC and methods of inducing proliferation of an immune cell or expanding a population of immune cells. The invention also relates to methods for inducing an immune response or treating a medical condition in a subject. The invention further relates to methods of identifying an antigenic peptide or method of identifying or detecting the presence of an immune cell that recognizes an antigen.
Disclosed herein are methods of bioproduction of enantiomerically pure or enantiomerically enriched 2-phenylglycinol or a derivative thereof by multiple enzyme-catalyzed chemical transformations in a one-pot reaction system.
The present invention relates to nucleic acids, double stranded nucleic acids (dsNAs), and agents for inhibiting expression of STATS. The present invention also includes nanoparticles comprising the nucleic acids, the dsNAs, and/or the agents as well as methods of treating cancer using the nucleic acids, the double stranded nucleic acids (dsNAs), the agents and/or the nanoparticles as disclosed herein. In one embodiment, the target region is within the 3′-UTR region of STATS mRNA.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
The present invention relates to a composite membrane comprising at least one 2D material and an inorganic porous material. The composite membrane described herein may be housed within a separation device which may be used for selective permeation of one or more gaseous compounds.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
A protective article is described. The protective article comprises auxetic structures including: (i) a first auxetic structure having a first auxetic plane exhibiting auxetic behaviour and a first auxetic structure axis, the first auxetic structure axis being substantially perpendicular to the first auxetic plane; and (ii) a second auxetic structure having a second auxetic plane exhibiting auxetic behaviour and a second auxetic structure axis, the second auxetic structure axis being substantially perpendicular to the second auxetic plane. The second auxetic structure axis is arranged in a non-parallel relationship to the first auxetic structure axis. An auxetic structure for use in a protective article and a method for forming the auxetic structure are also described.
The present invention relates to the detection of target nucleic acids using enzyme-assisted nanotechnology. More specifically, the present invention provides a molecular nanotechnology in the form of a transition-state DNA-enzyme molecular switch and methods of use that enables direct and sensitive detection of viral RNA targets in native clinical samples. In one embodiment, the detection comprising steps of providing a composition comprising at least one DNA polymerase enzyme, at least one enhancer, and at least one DNA polymerase inhibitor, wherein the DNA polymerase inhibitor is recognized and bound by the DNA polymerase enzyme via its conserved region, and is complementary to a portion of the enhance via its variable region. In another embodiment, the detection method comprising steps of providing a signalling nanostructure and detecting signal development, wherein a change in the intensity of signal. In an alternative embodiment, the target nucleic acid is a SARS-CoV-2 polynucleotide.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
The present disclosure describes delivery of nucleic acids to the central nervous system using extracellular vesicles, and in particular red blood cell extracellular vesicles.
A61P 25/00 - Drugs for disorders of the nervous system
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
55.
A HIGHLY SENSITIVE HEAT-REPRESSIBLE SPLIT-T7 POLYMERASE (THERMAL-T7RNAP) FOR APPLICATIONS IN BIOTECHNOLOGY
The present invention relates to heat-repressible split-T7 polymerases comprising temperature-sensitive domains of Tlpa protein fused with split T7 RNA polymerase (T7RNAP) to introduce thermal control into widely used T7 RNA polymerase, creating a heat-repressible Thermal-T7RNAP system. The invention further provides polynucleotides encoding the heat-repressible split-T7 polymerases, and methods of thermal control of bioproduction.
123123133 in each motif are connected to form a cyclophane moiety. At least one of the two C-terminus residues is an aromatic residue. The present disclosure also concerns a method of producing the polypeptide.
Disclosed herein are methods of obtaining ferulic acid. In one aspect, the present disclosure refers to a method of hydrolysing oryzanol to obtain ferulic acid, wherein the method comprises: i. hydrolysing an oryzanol-comprising material in a first hydrolysis step; and ii. exposing product of i. to a second hydrolysis step; wherein the first hydrolysis step is enzymatic, and the second hydrolysis step is chemical.
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 13/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
Disclosed herein is a nanomaterial electrolyte formed from a modified two-dimensional nanomaterial having a surface, where the surface is modified by a plurality of functional groups selected from one or more of the group consisting of imine, sulfonic acid, sulfonamide, amine, hydroxyl, carboxylic acid, thiol, and amide on the surface of the modified two-dimensional nanomaterial, where the nanomaterial electrolyte is capable of reversibly adopting a flat two-dimensional conformation or a scrolled 1-dimensional conformation upon a change to its ambient environment. There is also disclosed a method of effecting a change in conformation from one form to the other (and back again).
2222222222 and the host framework via multiple host−guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochemicals as building blocks for broad application.
C08G 79/08 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon a linkage containing boron
B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
A memory device for deep neural network, DNN, accelerators, a method of fabricating a memory device for deep neural network, DNN, accelerators, a method of convoluting a kernel [A] with an input feature map [B] in a memory device for a deep neural network, DNN, accelerator, a memory device for a deep neural network, DNN, accelerator, and a deep neural network, DNN, accelerator. The method of fabricating a memory device for deep neural network, DNN, accelerators comprises the steps of forming a first electrode layer comprising a plurality of bit-lines; forming a second electrode layer comprising a plurality of word-lines; and forming an array of memory elements disposed at respective cross-points between the plurality of word-lines and the plurality of bit-lines; wherein at least a portion of the bit-lines are staggered such that a location of a first cross-point between the bit-line and a first word-line is displaced along a direction of the word-lines compared to the cross-point between said bit-line and a second word-line adjacent the first word-line; or wherein at least a portion of the word-lines are staggered such that a location of a cross-point between the word-line and a first bit-line is displaced along a direction of the bit-lines compared to a cross-point between said word-line and a second bit-line adjacent the first bit-line.
The present disclosure concerns a method of promoting the ubiquitination of MK2 protein, comprising contacting the MK2 protein with a compound of Formula (I) or a salt, solvate, stereoisomer or prodrug thereof. The present disclosure also concerns compounds of Formula (I) and their use in treating a disease or condition associated with MK2 protein.
C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 11/00 - Drugs for disorders of the respiratory system
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
There are provided a composition and a method of preparing the composition. The composition comprises a composite powder material and an elastomer, wherein the composite powder material comprises a) tourmaline particles, b) rare-earth mineral particles, c) silicate mineral particles, d) metal oxide particles, and e) a binder, and wherein the sizes of the a), b), c) and d) are 5 pm or less. There are also provided an article and a method of preparing an article. There are further provided methods of using and uses of the article in the form of catheters, particularly urinary catheters.
A method of clock synchronization between first and second clocks on first and second ends, respectively, of an optical channel; and a system for clock synchronization between first and second clocks on first and second ends, respectively, of an optical channel. The method comprises the steps of generating light exhibiting thermal photon statistics, as opposed to a Poissonian timing statistic of coherent laser light; transmitting a portion of the light though the optical channel; determining timing information of single photon detection events of photons of the light at the first side of the optical channel using the first clock and at the second side of the optical channel using the second clock; using a temporal signature imprinted on the light as a result of the thermal photon statistics to identify temporal correlations between the single photon detection events at the first side of the optical channel and the single photon detection events at the second side of the optical channel; and determining an offset between the first and second clocks based on the identified temporal correlations.
Microfluidic devices and method of fabricating the microfluidic devices are provided. The microfluidic device (10) includes a base layer (100), a first layer (200) disposed on the base layer (100) and a second layer (300) disposed on the first layer (200). The first layer (200) defines one or more cell culture chambers (210). Each of the one or more cell culture chambers (210) configured to contain one or more cells. The second layer defines one or more air chambers (310). Each of the one or more air chambers (310) is adjacent a respective cell culture chamber (210). The microfluidic device allows the culture of single or multiple human-derived or animal-derived cells, or their co-culture with microorganisms under static or dynamic culture conditions.
An apparatus for collecting a saliva sample is described herein. In a described embodiment, the apparatus comprises a filter; and a pressure generator operable to generate pressure to cause the saliva sample to be transferred through the filter, the filter being configured to reduce a viscosity of the saliva sample as the saliva sample is transferred through the filter. A method collecting a saliva sample from a user is also described, among other aspects.
A method and a system for training a neural network. The method includes receiving, by a processing device, a training image, a reference label and a reference class activation map, the reference label and the reference class activation map associated with a corresponding unbiased image of the training image and generating, using the processing device, a class label and a class activation map based on the training image using the neural network. The method also includes calculating, using the processing device, a classification loss value based on differences between the reference label and the class label, and a class activation map loss value based on differences between the reference class activation map and the class activation map and updating, using the processing device, the neural network to minimise the classification loss value and the class activation map loss value to improve accuracy of the neural network in generation of the class label and the class activation map.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Goh, Xu Jie, Luke
Loh, Yue Xuan, Chantel
Bourguignon, Hugo, Jean Guillaume
Shen, Fang Yu, Tracy
Lau, Jo Hanan
Yen, Ching Chiuan
Foong, Kelvin, Weng Chiong
Leo, Sze Yin
Abstract
Disclosed is a method for fabricating an artificial jaw member. The method includes 3D printing a simulated jawbone such that the simulated jawbone comprises an inner material, outer shell at least partially encasing the inner material, and one or more tooth recesses, the outer shell being harder than the inner material, forming a sensor in each said tooth recess and an output connector in electrical communication with each said sensor, and providing a tooth in each said tooth recess.
A method of fabricating low dimensional nanostructures on a growth substrate, a single-crystalline low dimensional nanostructure, and a device comprising one or more single-crystalline low dimensional nanostructures. The method comprises fabricating low dimensional nanostructures on a growth substrate using physical vapor deposition, PVD, in a vacuum chamber wherein the low dimensional nanostructures are formed as a strain relief mechanism promoted by a similarity of crystal structure 2-dimensional symmetry between the growth substrate and the low dimensional nanostructures to be grown and a lattice mismatch between the growth substrate and the low dimensional nanostructures to be grown.
PRODUCTION OF ENANTIOPURE ALCOHOLS, AMINES AND ACIDS FROM RACEMIC EPOXIDES BY CASCADE BIOTRANSFORMATION INVOLVING EPOXIDE ISOMERIZATION AND DYNAMIC KINETIC RESOLUTION
Disclosed herein is a method of producing an enantiomerically pure or enantiomerically enriched alcohol, acid or amine from a racemic 2-alkyl-3-phenyl oxirane or derivative thereof and/or a racemic 2-alkyl-2-phenyl oxirane or derivative thereof using at least two enzymes, which method comprises subjecting the 2-alkyl-3-phenyl oxirane or derivative thereof and/or the 2-alkyl-2-phenyl oxirane or derivative thereof to at least two enzyme-catalyzed chemical transformations in a one-pot reaction system.
An ion microscope, a method of constructing an ion microscope, and a method of aligning an ion beam in an ion microscope. The microscope comprises a nano-aperture ion source; and a focusing system; wherein the focusing system is configured for selectively coaxially focusing an ion beam generated from an electron beam ionizing an ionizing gas in the nano-aperture ion source and the electron beam.
The present invention generally relates to the provision of a conditioned medium comprising magnetically-induced cell secretome, the methods of producing the same, and a system for 5 the production of said conditioned medium. More particularly, the present invention provides an improved method of producing a conditioned medium comprising cell secretome induced by a directionally-specific pulsing electromagnetic field (PEMF), wherein the conditioned medium of the present invention is capable of enhancing proliferation, differentiation, survival or senescence of recipient cells. Also provided are a system for the production of said 10 PEMF-conditioned medium and the improved conditioned medium thereof, suitable for use in medical and commercial applications.
A61N 2/04 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets using variable fields, e.g. low frequency or pulsating fields
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
PAXMAN COOLERS LTD (United Kingdom)
Inventor
Sundar, Raghav
Bandla, Aishwarya
Paxman, Neil
Paxman, Glenn
Moses, Rodney
Abstract
A compression apparatus for applying pressure to a subject is provided. The compression apparatus comprises a compression system; and one or more compression components connected to the compression system and secured around the subject, the one or more compression components comprising an air cavity. A method of applying pressure to a subject is also provided.
The present disclosure generally relates to a dosimeter assembly. In particular, the dosimeter assembly disclosed herein may be useful for monitoring gastric motility and pH as well as for detecting a radiation dose in a subject.
Design and fabrication method for a novel silicon-waveguide-integrated avalanche photodiode (APD) (100) is provided. Herein, an epitaxially grown APD device (95) comprises an absorption layer (35) of InGaAs and a multiplication layer (65) of InAlAs or certain other III-V compounds. Light propagating along a silicon-waveguide (80) is evanescently absorbed by the absorption layer (35) that is bonded on a silicon layer (15) and is optically coupled to the silicon-waveguide (80). Negligible variation is induced by the bonding process. This integrated APD (100) exhibits a high responsivity of substantially 0.99 A/W at substantially 1570 nm, a dark current (Idark) of substantially 7.6 nA at substantially 90% breakdown voltage (Vbr), and a maximum gain of substantially larger than 70. Integrating this novel APD (100) with silicon photonics and silicon CMOS could enable large-scale on-chip optical communication and computing with miniaturized size, as well as high operation speed with low parasitics.
G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
76.
DIGITAL CRISPR-BASED METHOD FOR THE RAPID DETECTION AND ABSOLUTE QUANTIFICATION OF NUCLEIC ACIDS
The present invention relates to a digital CRISPR-based method for detecting and quantitating target nucleic acids in a sample comprising: forming a mixture comprising sample nucleic acids; isothermal amplification reaction reagents for amplifying one or more target nucleic acid sequences; partitioning the mixture into a plurality of compartments; incubating the partitioned mixture at a temperature for isothermal amplification and Cas effector cleavage of an amplified DNA strand, detecting a signal from cleavage of the non-target sequence, thereby detecting the one or more target sequences in the sample, and determining the copy number of the target nucleic acid based on a Poisson distribution of the proportion of positive-to-negative compartments. The invention also relates to a method for detecting presence and/or of a disease in a subject, and a kit to quantitate nucleic acids in a sample.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
PAXMAN COOLERS LTD. (United Kingdom)
Inventor
Sundar, Raghav
Bandla, Alsharya
Binder, Jonathan Rex
Burke, Patrick
Unver, Ertu
Abstract
A compression wrap and method for temperature-controlled application of pressure on an arm of a subject, comprising a fluid bladder comprising a first element comprising two or more first flaps; a second element comprising one or more digital flaps; and a third element comprising two or more second flaps, wherein the first element and the third element are connected along a first edge and the second element is connected to the first element and the third element along a second edge.
The present disclosure teaches a method of predicting the responsiveness of a subject towards a Polo-like kinase 1 (PLK1) inhibiting therapy. In one embodiment, there is provided a method for predicting the responsiveness of a subject towards a Polo-like kinase 1 (PLK1) inhibiting therapy, the method comprising determining the level and/or activity of AT-rich interacting domain 1A (ARID1A) in a sample obtained from the subject.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
A system to provide a human-machine interface to enable a user in a real space to act/sense in a virtual space. The system includes: a ring wearable by a finger of the user; a plurality of sensors, and a plurality of feedback units. The plurality of sensors being multimodal, including: a tactile sensor disposed on an inner surface of the ring; and a temperature sensor disposed on an outer surface of the ring. The plurality of feedback units being multimodal, including: a vibrator disposed on the ring, the vibrator being disposed on the outer surface of the ring; and a heater disposed on the inner surface of the ring. The system includes a controller configured to drive the plurality of sensors and the plurality of feedback devices to enable concurrent multimodal sensing and multimodal feedback.
Disclosed herein is a spatially decoupled redox flow water electrolyzer, that has a hydrogen-producing catholyte section formed from a catholyte tank, having a cathode, and a hydrogen generation compartment, where the catholyte tank and the hydrogen generation compartment are fluidly connected to one another by a fluid pathway, so as to facilitate the circulation of a liquid catholyte from the catholyte tank to the hydrogen generation compartment and back to the catholyte tank and an oxygen-producing anolyte section formed from an anolyte tank, having an anode, and an oxygen producing compartment, where the anolyte tank and the oxygen producing compartment are fluidly connected to one another by a fluid pathway, so as to facilitate the circulation of a liquid anolyte from the anolyte tank to the oxygen producing compartment and back to the anolyte tank, an anion-exchange membrane is disposed between the catholyte and anolyte tanks and a current collector attached to the catholyte and anolyte tanks. In use, the hydrogen generation compartment contains a catalyst capable of catalysing hydrogen production when brought into contact with a cathodic redox mediator when the cathodic redox mediator is in a reduced state and the oxygen generation compartment contains a catalyst capable of catalysing oxygen production when brought into contact with an anodic redox mediator when the anodic redox mediator is in an oxidised state.
Agency for Science, Technology and Research (Singapore)
Inventor
Khin, Phone May
Low, Jin Huat
Chen, Chao-Yu
Yeow, Chen Hua
Zhang, Ying
Abstract
A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.
A magnetometer for measuring vector components of a magnetic field is described in an embodiment. The magnetometer comprising: a first section comprising a first magnetic layer; and a second section comprising a second magnetic layer, the second section being in-plane with and at an angle to the first section and is electrically connected to the first section. The first magnetic layer and the second magnetic layer each has a perpendicular magnetic anisotropy with near zero hysteresis, and are adapted to generate a first and second anomalous Hall voltage, respectively, in response to oscillatory spin-orbit torques generated in the respective magnetic layer and the magnetic field. The oscillatory spin-orbit torques are generated in response to an alternating current passing through the first magnetic layer and the second magnetic layer. The first anomalous Hall voltage includes a first second-harmonic Hall voltage associated with a first in-plane vector component of the magnetic field and the second anomalous Hall voltage includes a second second-harmonic Hall voltage associated with a second in-plane vector component of the magnetic field. The first in-plane vector component being in-plane with and at the angle to the second in-plane vector component. The first anomalous Hall voltage or the second anomalous Hall voltage includes a first-harmonic Hall voltage associated with an out-of-plane vector component of the magnetic field. A method for measuring vector components of a magnetic field using the magnetometer is also described.
An imager pixel comprising a forward-biased photo-detector with readout transistor for light-to-current conversion, and a ratiometric readout system comprising a current to pulse width converter. The readout system operates in a light mode to: generate a first current proportional to a photodetector current and a leakage current, on exposure to a photodetector voltage; and convert the first current to a first pulse width; and operates in a least significant bit (LSB) mode to: generate a second current proportional to a least significant bit (LSB) current and the leakage current, on exposure to a gate-source voltage; and convert the second current to a second pulse width. The system includes a converter circuit for converting the first pulse width to a count (CNTB) and the second pulse width to a count (CNTA), and a counting circuit for providing a radiometric readout based on a ratio of CNTB to CNTA.
The present disclosure relates to the diagnosis, treatment and prophylaxis of age-related diseases, and increasing healthspan. Provided are methods of treating or preventing an age-related disease/condition, and in particular of treating or preventing frailty, comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject. Also provided are agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling for use in such a method. Further provided is the use of agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling in the manufacture of a medicament for use in such a method.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61P 43/00 - Drugs for specific purposes, not provided for in groups
There is provided a multi-layered sheet mask comprising at least (a) a porous first layer having a first side and a second side, wherein the first side is opposite to the second side, and comprises a plurality of three-dimensional patterns extending therefrom; (b) a second layer attached to the second side of the porous first layer, the second layer comprising at least one pouch for receiving or containing at least one first active ingredient; a porous support structure; an air pouch that is sandwiched between the second side of the porous first layer and the porous support structure; and a plurality of microchannels that extend from the pouch and beyond the first side of the porous first layer when the air pouch is deflated; and (c) a third layer attached to the second layer for receiving or containing at least one second active ingredient. There is also provided a mould for producing the three-dimensional patterns of the porous first layer of the multi-layered sheet mask, and a method of producing the multi-layered sheet mask.
The present invention relates to a composition comprising or consisting of two or more bacteria strains, formulated for the prophylaxis or treatment of intestinal barrier dysfunction and/or heat stress in a subject. More particularly, the composition comprises two or more of Lactobacillus reuteri MM2-3, Lactobacillus plantarum WCSF1, Streptococcus thermophilus B of R and Escherichia coli Nissle 1917. The present invention also includes uses of the invention to treat conditions such as inflammatory bowel disease (IBD) and heat stress.
The invention provides a composite actuator suitable for soft robotics that performs motions which include any one of bending, twisting, and extending, or a combination thereof. The composite actuator comprises a bladder, and a skin that covers the bladder. The skin has an overall Young's modulus that is larger than that of the bladder for acting as a deformation- controlling constraint so that motions are performed by the composite actuator during inflation or pressurisation of the bladder. The skin comprises one or more layers, with at least one layer being anisotropic in terms of having a minimum Young's modulus in a first direction and a maximum Young's modulus in a second direction that is orthogonal to the first direction, wherein the skin layer substantially envelops the bladder while being stretched along the first direction.
F15B 15/10 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
F15B 7/06 - Fluid-pressure actuator systems in which the movement produced is definitely related to the output of a volumetric pump; Telemotors - Details
F15B 15/00 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith
B25J 11/00 - Manipulators not otherwise provided for
The invention provides a seamless chamber actuator (100,100a,100b) which comprises a base layer (110,110a), a second layer (150,150a) and a substantially zero-volume actuation chamber (108) formed between the base and the second layers. In another embodiment, a torsion housing (220) is mounted on the seamless chamber actuator (100b) to provide a jamming actuator (200). The jamming actuator (200) is further configured with a glove to provide a wrist jamming actuator (200a). In another embodiment, a bending actuator (300) is formed by a base layer (310), a flat groove, a perforated membrane (330), a corrugated layer (350) and a substantially zero-volume actuation chamber (308,308a) is formed between the base and the corrugated layers. These seamless chamber actuators (100,100a,100b), jamming actuators (200,200a) or bending actuators (300) can be configured for force feedback, haptic sensation, force assistive or force resistive devices, such as, in VR, AR or body rehabilitation.
F15B 15/10 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
F15B 7/06 - Fluid-pressure actuator systems in which the movement produced is definitely related to the output of a volumetric pump; Telemotors - Details
B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
F15B 15/00 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith
B25J 11/00 - Manipulators not otherwise provided for
Disclosed is an impedance monitoring system for detection of attacks on a secure system. The impedance monitoring system comprises a perturbation current generator (PCG), a voltage sensing ring oscillator (VSRO), and a controller. The PCG generates a perturbation current to excite a supply impedance of the secure system and the controller counts oscillations in the VSRO, resulting from voltage changes in the secure system, to detect an attack. In particular, the controller detects an attack by capturing a reference VSRO count, capturing a subsequent VSRO count for a non-zero perturbation current, and normalising the subsequent VSRO count based on the reference VSRO count.
G06F 21/72 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information in cryptographic circuits
G01R 27/16 - Measuring impedance of element or network through which a current is passing from another source, e.g. cable, power line
90.
DETECTOR SCHEME FOR DETECTING LASER VOLTAGE PROBING ATTACKS
Disclosed is a sensor fabric for detecting an attack on transistors. The fabric includes a plurality of sensor clusters. Each sensor cluster comprises a plurality of photodetectors and transistors, each photodetector being disposed next to a respective said transistor, a standard cell and an aggregator. The standard cell comprising a thresholding comparator for comparing a first input from a first group of the photodetectors of the respective cluster and a second input from a second group of the photodetectors of the respective cluster, the first input and second input being proportional to incident light sensed by the respective photodetectors, and flipping an output of the standard cell if a difference between the first input and second input exceeds a predetermined threshold. The aggregator aggregates the outputs from the clusters to produce an aggregated output, and triggering an alarm on detection of an attack based on the aggregated output.
G06F 21/71 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information
The present disclosure relates to a method of 3D printing a stent, comprising performing selective laser melting on a Nitinol powder in order to form the stent, wherein selective laser melting is performed with particular parameters. The 3D printed stent can be curved. The present disclosure also relates to the 3D printed stent thereof, a stent delivery device comprising a tube and a crimped 3D printed stent slidably disposed within the tube, and a method of delivering a stent in a stent delivery device into a channel.
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
B22F 5/10 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
B22F 10/366 - Scanning parameters, e.g. hatch distance or scanning strategy
B22F 10/368 - Temperature or temperature gradient, e.g. temperature of the melt pool
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Tay, Zirui, Matthew
Lin, Weikang, Nicholas
Cheow, Lih Feng
Chen, Chia-Hung
Rénia, Laurent Claude Stéphane
Ng, Fong Poh, Lisa
Abstract
The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; iincubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.
A computing circuit comprising a plurality of reconfigurable processing elements (PEs); data communication lines connecting an output port of each of the PEs with an input port of each other one of the PEs; wherein the computing circuit is configured to execute a data flow model by configuring at least a second subset of the plurality of PEs to perform a respective discrete computation implementing the data flow model; and wherein a first PE of the second subset of PEs is configured to perform its respective discrete computation on receipt of a ready to receive output signal from one or more destination PEs; wherein the one or more destination PEs are configured to perform a computation on the output of the first PE according to the data flow model.
G06F 15/82 - Architectures of general purpose stored program computers data or demand driven
G06F 9/38 - Concurrent instruction execution, e.g. pipeline, look ahead
G06F 7/57 - Arithmetic logic units [ALU], i.e. arrangements or devices for performing two or more of the operations covered by groups or for performing logical operations
94.
A METHOD TO MONITOR VIRUS-SPECIFIC T CELLS IN BIOLOGICAL SAMPLES
The present invention relates to a method of diagnosing and/or monitoring of virus infection and/or response to vaccination by generating a profile of a virus-specific T cell response that can (i) discriminate between virus infected and uninfected individuals, (ii) determine the effect of vaccination on T cell response, and (iii) determine the effect of viral variants on T cell response. More particularly, the described virus-specific T cell profiling is based on the detection of activated antigen-specific T lymphocytes responding to pools of selected short peptides from virus proteins. These peptide sequences have been selected for their immunogenicity. The profiling is typically performed using ELISPOT, but may also be performed using other techniques such as qPCR, more particularly direct qPCR. The present invention also includes kits for use in the methods of the invention.
Systems and methods for integration of SRT datasets by receiving raw SRT datasets obtained from a plurality of tissue sample, performing dimension reduction on the plurality of SRT datasets by a dimension reduction model, performing spatial clustering of the plurality of SRT datasets based on a clustering model, wherein the dimension reduction and spatial clustering are performed in parallel to determine an integrated SRT representation of the plurality of tissue samples.
The present invention describes an adaptive learning and training system (100,100a) and method (200) offered at an institution (10,10a,10b,etc.). The institution has 3 databases: a users database (126), a learning content database (122) and a training content database (124). A learning and training software application (130), linked to the databases, includes 3 modules: a Content Classification and Context Prediction module (150), an Adaptive Learning module (170) and a Skill Level module (190). The Adaptive Learning module (170) includes a Machine Learning Recommender (172) and an AI instructor (174). The module (150) classifies the learning contents and training contents into topics/subtopics, required skill levels and mandatory frequencies. In use, the ML Recommender (172) recommends a topic/subtopic of a skill level proximal to a user's course ID. User response is assessed in the module (190) by a new skill score; the new skill score may be modulated by time elapsed between learning/training sessions.
G09B 7/02 - Electrically-operated teaching apparatus or devices working with questions and answers of the type wherein the student is expected to construct an answer to the question which is presented or wherein the machine gives an answer to the question presented by the student
Agency for Science, Technology and Research (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Chin, Zheng Yang
Zhang, Haihong
Guan, Cuntai
Wang, Chuan Chu
Lee, Tih Shih
Abstract
Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.
An optical range finding device and an optical range finding method. The method comprises the steps of generating light with a super Poissonian timing statistic; splitting the light into a reference beam and a probe beam and directing the probe beam towards a target in free-space; illuminating a first single-photon detector by the reference beam; illuminating a second single-photon detector by the probe beam after reflection by the target in free-space; detecting a time difference between detection of quantum-correlated photons in the reference beam and the reflected probe beam for determining a distance between the device and the target.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Panengad, Pradeep Paul
Unniyampurath, Unnikrishnan
Wang, Linfa
Dharmaraj, Rajesh Babu
Nambiar, Ajay Purushothaman
Anantharajan, Senthil Kumar
Naduparambil, Manoj Krishnan
Abstract
A device for debriding tissue is described. In an embodiment, the device comprises an electrolysis unit 300 having two electrodes 306, 310. The electrolysis unit 300 is configured to receive an electrolyte for electrically connecting the two electrodes 306, 310. The two electrodes 306, 310 are adapted to connect to a power supply 314 to receive an electric current for electrolysis of the electrolyte, where in use, one of the two electrodes 306, 310 is adapted to provide an acidic region or an alkaline region to the tissue during electrolysis of the electrolyte for debriding the tissue. A method for debriding tissue using the aforementioned device is also described.
Disclosed herein is a method of recycling a spent battery material, the method comprising the steps of (a) providing a first reaction compartment fluidly connected to a cathode side of an electrolyser, (b) in a second reaction compartment, LiOH is added to precipitate the Co2+to provide a filtered alkaline electrolyte solution which is supplied to a third reaction compartment when the Co2+44 and accepts the filtered alkaline electrolyte solution from the second reaction compartment, the reaction loops are continued until the Li+ ions are substantially or are entirely removed from the electrolyte. Also disclosed herein are an electrolytic device comprising an electrolyser, a first to third cathode tank, and an anode tank, and an electrolytic device comprising a first electrolyser, and a second electrolyser.
