The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes and therapy selection in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes and therapy selection in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes and therapy selection in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for scientific or medical research use; Assays and reagentsfor use in genetic research. Reagents for medical use; genetic tests comprised of reagents for medical purposes. Blood collection kit comprised of blood collecting tubes. Providing laboratory research services in the field of genetic testing; medical and scientific laboratory services in the field of genetic testing. Medical testing services, namely, genetic testing; providing medical testing services and information for treatment purposes in the field of genetic research and disease classification.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Blood collection kit comprised of blood collecting tubes for use in the detection of tumor-specific biomarkers in tumor tissue and blood testing for the recurrence of cancer and the ongoing monitoring of therapeutic effectiveness Providing laboratory research services in the field of genetic testing for the detection and screening of cancer, namely, development of assays for detection of tumor-specific biomarkers in tumor tissue and blood; medical and scientific laboratory services in the field of genetic testing for the detection and screening of cancer, namely, development of assays for detection of tumor-specific biomarkers in tumor tissue and blood Medical testing services, namely, genetic testing for the detection and screening of cancer, namely, use of a bespoke assay for detection of tumor-specific biomarkers in tumor tissue and blood, testing for the recurrence of cancer and the ongoing monitoring of therapeutic effectiveness; providing medical testing services for the detection and screening of cancer and information for treatment purposes in the field of genetic research and disease classification, namely, use of a bespoke assay for detection of tumor-specific biomarkers in tumor tissue and blood, testing for the recurrence of cancer and the ongoing monitoring of therapeutic effectiveness
The technologies disclosed herein relate to a system and method for transferring markings. The system can include an imaging device for imaging a stained slide and an unstained slide, a display for displaying one or more images of the stained slide and the unstained slide. In various embodiments, the system can include a mechanical stage, such as a scaffold, for positioning or orienting the stained slide with respect to the unstained slide. In various embodiments, the system can be coupled with a first application for aligning the images to enable digital marking of the unstained slide and a second application for digitally marking one or more features and transferring the digital markings into coordinates to be used for further processing, such as for dissection.
The technologies disclosed herein relate to a system and method for transferring markings. The system can include an imaging device for imaging a stained slide and an unstained slide, a display for displaying one or more images of the stained slide and the unstained slide. In various embodiments, the system can include a mechanical stage, such as a scaffold, for positioning or orienting the stained slide with respect to the unstained slide. In various embodiments, the system can be coupled with a first application for aligning the images to enable digital marking of the unstained slide and a second application for digitally marking one or more features and transferring the digital markings into coordinates to be used for further processing, such as for dissection.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes and therapy selection in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes and therapy selection in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
13.
Method to use gene expression to determine likelihood of clinical outcome of renal cancer
The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16C 99/00 - Subject matter not provided for in other groups of this subclass
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 25/00 - ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Laboratory research in the field of cancer research and disease classification; providing laboratory research services in the field of genetic testing, including next-generation sequencing (ngs), namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Laboratory research in the field of cancer research and disease classification; providing laboratory research services in the field of genetic testing, including next-generation sequencing (ngs), namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Laboratory research in the field of cancer research and disease classification; providing laboratory research services in the field of genetic testing, including next-generation sequencing (ngs), namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Laboratory research in the field of cancer research and disease classification; providing laboratory research services in the field of genetic testing, including next-generation sequencing (ngs), namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Providing temporary online use of non-downloadable software for use by physicians for ordering patient tests and for use in collecting, managing, analyzing, storing, sharing, and comparing medical information, patient records, patient preferences, patient laboratory orders, patient tests and analysis; all of the foregoing for use in the field of cancer diagnostics, prognostics and treatment recommendations
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary online use of non-downloadable software for use by physicians for ordering patient tests and for use in collecting, managing, analyzing, storing, sharing, and comparing medical information, patient records, patient preferences, patient laboratory orders, patient tests and analysis; all of the foregoing for use in the field of cancer diagnostics, prognostics and treatment recommendations.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals, namely, oncologists and treating physicians for cancer patients, in the form of reports in the field of cancer diagnostics and prognostics; Medical testing services, namely, genetic testing and next generation sequencing test for diagnosis and treatment of cancer
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary online use of non-downloadable software for use by physicians for use in collecting, managing, analyzing and comparing medical information, patient records, patient laboratory orders, patient tests and analysis; all of the foregoing for use in the field of cancer diagnostics, prognostics and treatment recommendations
29.
DNA methylation and mutational analysis methods for bladder cancer surveillance
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
Systems and methods of processing a biological sample for a biological assay are disclosed. The systems and methods may include contacting the biological sample with a contact medium comprising a particulate substance blasted with pressurized air under conditions sufficient to effectuate at least partial transfer of a component in the biological sample to the contact medium and removing the contact medium from the biological sample. The systems and methods may include further collecting the particulate substance, preparing the particulate substance for analysis, and analyzing the particulate substance.
Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.
Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.
A system for automation of sample preparation is disclosed. The system for automation includes a fixture configured to hold a sample and a reader system configured for receiving information pertinent to the sample. In various implementations, the system includes a cutting system configured for removing a portion of the sample. In various implementations, the system includes a cutting system configured for cutting the sample into at least two portions. In various implementations, the system further includes a first bin for collecting a first portion of the at least two portions of the sample. In various implementations, the system also includes a second bin for collecting a second portion of the at least two portions of the sample. In various implementations, the plurality of specimens are arranged linearly along one direction or arranged laterally in a two-dimensional array.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples; kits consisting primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing; diagnostic kits comprised primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing. Diagnostic kits comprised of medical diagnostic reagents and diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; medical reagents; medical diagnostic reagents; clinical diagnostic reagents; kits for medical purposes consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; diagnostic kits consisting primarily of enzymes for medical purposes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; medical diagnostic assays for testing of bodily fluids and tissue samples for use in disease detection and testing for medical and prognostic purposes; medical diagnostic reagents and assays for testing bodily fluids and tissue samples for use in disease testing and classification; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purpose; Assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; Diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; Diagnostic kits comprised primarily of diagnostic reagents for clinical or medical laboratory use and diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis. Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing information in the field of cancer research and disease classification. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification; Providing medical testing services in the field of cancer research and disease classification.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples; kits consisting primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing; diagnostic kits comprised primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing. Diagnostic kits comprised of medical diagnostic reagents and diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; medical reagents; medical diagnostic reagents; clinical diagnostic reagents; kits for medical purposes consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; diagnostic kits consisting primarily of enzymes for medical purposes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; medical diagnostic assays for testing of bodily fluids and tissue samples for use in disease detection and testing for medical and prognostic purposes; medical diagnostic reagents and assays for testing bodily fluids and tissue samples for use in disease testing and classification; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes; Assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis; diagnostic kits comprised primarily of diagnostic reagents for clinical or medical laboratory use and diagnostic assays for testing tissue samples and bodily fluids for use in cancer detection, analysis and prognosis. Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing medical research services and information in the field of cancer research and disease classification. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples; kits consisting primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing; diagnostic kits comprised primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing. Diagnostic kits comprised of medical diagnostic reagents and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; medical reagents; medical diagnostic reagents; clinical diagnostic reagents; kits for medical purposes consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; diagnostic kits consisting primarily of enzymes for medical purposes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; medical diagnostic assays for testing of tissue samples for use in disease detection and testing for medical and prognostic purposes; medical diagnostic reagents and assays for testing tissue samples for use in disease testing and classification; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes; Assays for testing tissue samples for use in cancer detection, analysis and prognosis; diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; diagnostic kits comprised primarily of diagnostic reagents for clinical or medical laboratory use and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis. Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing medical research services and information in the field of cancer research and disease classification. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples; kits consisting primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing; diagnostic kits comprised primarily of enzymes for scientific and research purposes, nucleic acids, buffers, reagents and assays for use in disease testing. Diagnostic kits comprised of medical diagnostic reagents and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; medical reagents; medical diagnostic reagents; clinical diagnostic reagents; kits for medical purposes consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; diagnostic kits consisting primarily of enzymes for medical purposes, nucleic acids, buffers, reagents and assays for use in disease testing and classification; medical diagnostic assays for testing of tissue samples for use in disease detection and testing for medical and prognostic purposes; medical diagnostic reagents and assays for testing tissue samples for use in disease testing and classification; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes; assays for testing tissue samples for use in cancer detection, analysis and prognosis; diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; diagnostic kits comprised primarily of diagnostic reagents for clinical or medical laboratory use and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis. Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing medical research services and information in the field of cancer research and disease classification. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Diagnostic kits comprised of medical diagnostic reagents and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; medical diagnostic reagents; diagnostic kits consisting primarily of enzymes for medical purposes, nucleic acids, buffers, reagents and assays for use in disease testing; medical diagnostic assays for medical and prognostic purposes; medical diagnostic reagents and assays for testing tissue samples for use in disease detection, namely, cancer; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
47.
DNA METHYLATION AND MUTATIONAL ANALYSIS METHODS FOR BLADDER CANCER SURVEILLANCE
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples. Diagnostic kits comprised of diagnostic reagents and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; medical diagnostic reagents; clinical diagnostic reagents; diagnostic kits consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing; medical diagnostic assays for medical and prognostic purposes; medical diagnostic reagents and assays for testing tissue samples; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes. Providing laboratory research services in the field of gene expression, namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification; Providing medical testing services and information in the field of cancer research and disease classification.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for scientific or medical research use, namely, reagents for use in preparation of RNA samples. Diagnostic kits comprised of diagnostic reagents and diagnostic assays for testing tissue samples for use in cancer detection, analysis and prognosis; medical diagnostic reagents; clinical diagnostic reagents; diagnostic kits consisting primarily of enzymes, nucleic acids, buffers, reagents and assays for use in disease testing; medical diagnostic assays for medical and prognostic purposes; medical diagnostic reagents and assays for testing tissue samples; enzyme preparations for medical purposes; biological preparations for the detection, diagnosis and monitoring of cancer; preparations for detecting genetic predispositions for medical purposes; biological preparations for use in the diagnosis, analysis and prognosis of cancer; diagnostic agents, preparations and substances for medical purposes. Providing laboratory research services in the field of gene expression, namely, cancer biology. Medical testing for diagnostic and prognostic purposes in the field of cancer and disease classification; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification; providing medical testing services and information in the field of cancer research and disease classification.
51.
ALGORITHMS AND METHODS FOR ASSESSING LATE CLINICAL ENDPOINTS IN PROSTATE CANCER
The present disclosure relates to uses of a multiple gene-expression based Genomic Prostate ScoreTM (GPSTM ) algorithm for assessment of various clinical endpoints in prostate cancer patients, such as risks of clinical recurrence (CR), biochemical recurrence (BCR), distant metastasis (Mets), and prostate cancer death (PCD). In some embodiments, GPS result is determined for low and intermediate risk prostate cancer patients in order to assist in determining treatment strategies for those patients.
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
52.
Gene expression markers for breast cancer prognosis
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
53.
ALGORITHMS AND METHODS FOR ASSESSING LATE CLINICAL ENDPOINTS IN PROSTATE CANCER
The present disclosure relates to uses of a multiple gene-expression based Genomic Prostate ScoreTM (GPSTM ) algorithm for assessment of various clinical endpoints in prostate cancer patients, such as risks of clinical recurrence (CR), biochemical recurrence (BCR), distant metastasis (Mets), and prostate cancer death (PCD). In some embodiments, GPS result is determined for low and intermediate risk prostate cancer patients in order to assist in determining treatment strategies for those patients.
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
54.
Methods for depleting RNA from nucleic acid samples
The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognosis and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognosis and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer services, namely, creating an on-line community for registered users to receive information and to participate in discussions and form virtual communities in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing a secured-access website featuring technology that allows registered users the ability to send and receive information and to share documents, images and information in the fields of health, genomics, cancer, cancer treatments and personalized medicine; Computer services, namely, providing a website featuring technology that automates the publication of research and information pertaining to health, genomics, cancer, treatment of cancer, and personalized medicine; Providing online research services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine. Providing a website via a global computer network featuring medical information in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing online information services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer services, namely, creating an on-line community for registered users to receive information and to participate in discussions and form virtual communities in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing a secured-access website featuring technology that allows registered users the ability to send and receive information and to share documents, images and information in the fields of health, genomics, cancer, cancer treatments and personalized medicine; Computer services, namely, providing a website featuring technology that automates the publication of research and information pertaining to health, genomics, cancer, treatment of cancer, and personalized medicine; Providing online research services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine. Providing a website via a global computer network featuring medical information in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing online information services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing medical testing services and information in the field of cancer research and disease classification
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer services, namely, creating an on-line community for registered users to receive information and to participate in discussions and form virtual communities in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing a secured-access website featuring technology that allows registered users the ability to send and receive information and to share documents, images and information in the fields of health, genomics, cancer, cancer treatments and personalized medicine; Computer services, namely, providing a website featuring technology that automates the publication of research and information pertaining to health, genomics, cancer, treatment of cancer, and personalized medicine; Providing online research and reference services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine Providing a website via a global computer network featuring medical information in the fields of health, genomics, cancer, cancer treatments, and personalized medicine
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer services, namely, creating an on-line community for registered users to receive information and to participate in discussions and form virtual communities in the fields of health, genomics, cancer, cancer treatments, and personalized medicine; Providing a secured-access website featuring technology that allows registered users the ability to send and receive information and to share documents, images and information in the fields of health, genomics, cancer, cancer treatments and personalized medicine; Computer services, namely, providing a website featuring technology that automates the publication of research and information pertaining to health, genomics, cancer, treatment of cancer, and personalized medicine; Providing online research and reference services via an on-line computer network in the field of health, genomics, cancer, cancer treatments and personalized medicine Providing a website via a global computer network featuring medical information in the fields of health, genomics, cancer, cancer treatments, and personalized medicine
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
66.
Method to use gene expression to determine likelihood of clinical outcome of renal cancer
The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic, prognostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing medical research services in the field of cancer research and disease classification, namely non-diagnostic medical testing Medical testing for diagnostic or treatment purposes in the field of cancer; providing medical information to medical professionals in the form of reports in the field of cancer and disease classification
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing temporary online use of non-downloadable software for secure messaging and notification in connection with patient tests and analysis, patient records, medical records, content, documents, and images, for use in the fields of cancer diagnostics and prognostics; providing temporary use of non-downloadable software for use in collecting, managing, analyzing, storing, sharing, and comparing medical information, patient records, patient laboratory orders, patient tests and analysis, and reporting on the same, for use in the field of cancer diagnostics and prognostics. Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer diagnostics and prognostics; medical reporting services, namely, compilation of medical reports; providing medical information, consultancy and advisory services; health care; health care consultancy services; medical data analysis; patient medical data analysis; Health care services, namely, providing a database of diseases and the collection of disease data and information all for diagnostic and prognostics purposes in the field of cancer; Health care services, namely, providing a database in the field of patient diagnostic molecular, biomarker, genomic medicine, and clinical data including laboratory values with systems for output of customized knowledge and information and featuring inputting and collection of data and information all for diagnostic and prognostics purposes; Providing health information; Medical information; Medical monitoring and reporting services; Predictive modeling of data in the fields of medicine and healthcare; Patient outcome analysis services, namely, providing on-line record analysis services designed to provide medical professionals and patients with custom tailored information about the range of possible diagnoses, treatments and therapies and evaluating patient records, disease markers to provide patients with information about possible diagnoses, treatments and therapies; all of the foregoing for use in the field of cancer diagnostics and prognostics.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing medical testing services and information in the field of cancer research and disease classification Medical testing for cancer diagnosis and treatment purposes; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification for diagnosis and treatment purposes
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical testing for diagnostic and treatment purposes in the field of cancer; Providing medical information to medical professionals in the form of reports in the field of cancer
79.
Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing laboratory research services in the field of gene expression, namely, cancer biology; Providing a secured-access website featuring non-downloadable software for use in the medical diagnostics and laboratory research services fields; Software-as-a-service (SaaS) featuring software for use in the medical diagnostics and laboratory research services fields. Medical testing for diagnostic and treatment purposes in the field of cancer research and disease classification; Providing medical information to medical professionals in the form of reports in the field of cancer and disease classification.
81.
Methods for depleting RNA from nucleic acid samples
The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
82.
Gene fusions and alternatively spliced junctions associated with breast cancer
The present invention relates to gene fusions and alternative spliced junctions associated with breast cancer. The present invention also relates to novel methods of identifying gene fusions and alternative spliced junctions in RNA sequencing data. The present invention further relates to predicting prognosis of a breast cancer patient based on the number of gene fusion events.
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
83.
METHODS OF INCORPORATION OF TRANSCRIPT CHROMOSOMAL LOCUS INFORMATION FOR IDENTIFICATION OF BIOMARKERS OF DISEASE RECURRENCE RISK
The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
ABSTRACT The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence. Date Recue/Date Received 2020-09-15
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient.
The present invention relates to RNA transcripts, or expression products thereof, associated with breast cancer prognosis. These RNA transcripts, or expression products thereof are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of counting sequencing reads.
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
90.
GENE FUSIONS AND ALTERNATIVELY SPLICED JUNCTIONS ASSOCIATED WITH BREAST CANCER
The present invention relates to gene fusions and alternative spliced junctions associated with breast cancer. The present invention also relates to novel methods of identifying gene fusions and alternative spliced junctions in RNA sequencing data. The present invention further relates to predicting prognosis of a breast cancer patient based on the number of gene fusion events.
Methods for predicting the efficacy of a treatment with a platinum-based chemotherapy drug in a patient with cancer are disclosed. The methods generally involve determining an expression level of a gene product that correlates with responsiveness to treatment with a platinum-based chemotherapy drug, which may be oxaliplatin. The cancer may be colorectal cancer.
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a prostate cancer patient. The genes may be grouped into functional gene subsets for calculating a quantitative score useful to predict a likelihood of a clinical outcome for a prostate cancer patient.
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.
The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.
Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers.
