A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.
Systems, devices, kits and methods for performing point of care assays, in particular for performing a plurality of concurrent isothermal nucleic acid amplification assays in a point of care environment.
The present invention relates to test devices for determining the presence of one or more analytes in a sample, methods for using such test devices and methods of manufacturing such test devices. The test devices comprise a substrate having disposed thereon, two or more conductive tracks, a reagent composition and a top layer covering a portion of the conductive tracks which forms, in combination with the substrate, a sample receiving chamber. At least one of the conductive tracks comprises a conductive polymer.
C07D 265/38 - [b, e]-condensed with two six-membered rings
C07D 279/18 - [b, e]-condensed with two six-membered rings
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to monitor disease progression or treatment.
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
5.
ASSAY AND METHOD FOR DETERMINING INSULIN-RESISTANCE
The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to monitor disease progression or treatment.
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Disclosed is an assay result reading apparatus for use with an assay in which a detectable substance tends to accumulate within a detection zone of the assay, the reading apparatus comprising: a housing or baffle, having a window therein; a light source which emits light through the window so as to illuminate the detection zone of the assay; and a light detector to detect the amount of light reflected and/or transmitted by the detection zone, which amount is at least partly dependent on the amount of detectable substance accumulated in the detection zone; wherein the shape of the window is adapted to render the reading apparatus less sensitive, preferably insensitive, to minor mis-positioning of the detection zone relative to one or more of the window, the light source and the light detector.
In accordance with the present invention there is provided a bi-stable oscillator circuit for detecting a load imparted to a surface. The bi-stable oscillator comprises an electrical amplifier, at least one resonator comprising an electrical transducer having a resonant frequency, a surface of the resonator forming the surface on which the load is to be detected and an impedance network having a resonant frequency. The resonator is arranged to be exposed to an environment under test, and the resonator and the impedance network are connected in parallel with the electrical amplifier such that when a load imparted to the surface exceeds a pre-determined threshold value the oscillator circuit oscillates at the resonant frequency of the impedance network and when a load imparted to the surface is less than the threshold value the oscillator circuit oscillates at the resonant frequency of the resonator, switching of the circuit oscillation frequency being indicative of the load crossing the predetermined threshold value.
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
H03B 5/32 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element being electromechanical resonator being a piezoelectric resonator
G01D 5/243 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the phase or frequency of ac
A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple.
A detection device (100) comprises a detecting chamber (32) containing a detecting element for analyzing whether a specimen containing an analyte, and an indicating element (8) displaying whether the detection is activated. The method for using the detection device (100) is also disclosed.
A device and a method for analyzing an analyte in a liquid sample are provided. The device comprises a detecting chamber included in a detection device for containing a detecting element; a liquid sample transferring chamber; and a film with small pores disposed between the detecting chamber and liquid sample transferring chamber. When the detection device is inserted into a liquid sample collecting chamber, the liquid sample in the collecting chamber enters the liquid sample transferring chamber but can not enter the detecting chamber via the film with small pores. When a piston is inserted into the liquid sample transferring chamber, the piston forces a part of liquid sample in the liquid sample transferring chamber to enter the detecting chamber via the film with small pores. Using the device and the method can determine an analyte in a sample quantitatively and can complete the detection in one step.
A multiple test strip assembly comprising a non-bibulous support, a sample application site comprising a defined area of said non-bibulous support delimited by a liquid impervious barrier, and at least two test strips placed on said support, each having a bibulous sample receiving pad, wherein the sample receiving pad of each of said at least two test strips is in contact with said sample application site.
A detection device and a detection method are disclosed. The detection device comprises a sample inlet (132) that allows liquid samples flowing from a collection chamber (20) to a detection chamber (10), which comprises a through hole (135) that allows gases circulation between the detection chamber and the collection chamber, and a sheath (140) that prevents liquid samples from entering into the detection chamber from the collection chamber via the through hole. The detection chamber contains test reagent strips (120) to detect whether samples contain interested analytes. The detection device further comprises a protrusion (131) that enables the detection device standing tilted in the traverse direction. The detection method comprises collecting liquid samples as the first step, followed by standing the device tilted in its traverse direction through a protrusion support, and detecting whether samples contain the analytes.
A method for separating red blood cells from a blood sample and use thereof, comprises: a) contacting the blood sample with a receptor capable of binding to fibrins in the blood sample; and b) subsequently separating the fibrin-binding receptor from the blood sample. Through employing the method, inhibition of the flow of blood samples caused by red blood cells could be removed, and background interference produced by red blood cells could be reduced. The method and apparatus thereof do not adversely affect detection results.
A method and an apparatus for optically reading test devices having an identification data zone associated with the test device and test zone arranged to receive a sample. The apparatus comprises an optical sensing module, an image processing module coupled to the optical sensing module, a control module coupled to the optical sensing module and to the image-processing module. The optical sensing module is arranged to sense both the test zone and the identification data zone and deliver the sensed data to the image processing module responsive to the control module. Further, the image-processing unit is arranged to perform image processing on the sensed data from the test zone and from the identification data zone and further determine the sample according to the sensed data from the test zone in view of the sensed data from the identification data zone responsive to the control unit.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
Disclosed is a method for determining a quantitative estimate of the length of time since conception in a female mammalian subject, the method comprising: a)providing a liquid sample suspected of containing hCG; b)measuring, by means of an assay or assay device, an analyte measurement signal, whose value is dependent upon the level of hCG; c)comparing the measured signal value to an analyte threshold, wherein said analyte threshold corresponds to a time since conception; d)providing an quantitative estimate of the length of time since conception based upon the comparison in step (c).
SPD SWISS PRECISION DIAGNOSTICS GMBH (Switzerland)
ALERE SWITZERLAND GMBH (Switzerland)
Inventor
Raj, Balbir
Tolley, David
Abstract
Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of : contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.
A method is described for determining the presence of an analyte of interest in a sample which, method comprises contacting the sample with: (i) a purified first reporter fragment pair member comprising an interactor domain with affinity for the analyte of interest; and (ii) a purified second reporter fragment pair member comprising an interactor domain with affinity for the analyte of interest and operable in reconstituting an active enzyme upon association with the first reporter fragment pair member through the affinities of the interactor domains of the first and second reporter fragment pair members with the analyte of interest; under in vitro assay conditions which allow the first and second reporter fragment pair members to associate in the presence of analyte of interest in the sample through the affinity of the interactor domains with the analyte to produce a glow luminescent signal through the action of the reconstituted active enzyme on a substrate; and detecting the presence or absence, or extent, of a glow luminescent signal.
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