The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and inflammatory disorders and/or for preventing or reducing the risk of graft rejection in transplantation.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
An apparatus (1) for photolithographically forming an ophthalmic lens (L) comprises:
a container (2) comprising a container bottom (20) with an inner surface (200) including a concave portion (201);
a piston (4) comprising a distal piston end face (400) with a convex portion (401);
wherein the piston (4) is arranged in the container (2) such that the convex portion (401) faces the concave portion (201),
and wherein the piston is movably arranged in the container (2);
a light source (5, 50) being arranged beneath the container bottom (20) for emitting light towards the container bottom (20);
a mask (6) arranged between the light source (5, 50) and the container bottom (20), the mask (6) comprising a plurality of pixels (60) which are configured to be individually controlled to either allow the light emitted from the light source (5, 50) to pass through the individual pixels (60) and to impinge on that part of the container bottom (20) having the concave portion (201) of the inner surface (200), or to not allow the light emitted from the light source (5, 50) to pass through the individual pixels (60) and to prevent the light from impinging the container bottom (20), and
a control unit (7) for controlling the individual pixels (60) of the mask (6) to allow for a formation of the ophthalmic lens (L) layer by layer (L1-L4).
Described herein are molecular glue degrader compounds that bind to both a target protein and a RING E3 Ubiquitin Ligase, as well as related compositions and methods of use, e.g., for degradation of the target protein and/or the treatment of a disease, disorder, or condition.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations. Collection and preservation of biological tissue, blood and
cells; Medical diagnostic services; medical treatment
services; provision of information and data for diagnosis
and medical treatment.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations. Collection and preservation of biological tissue, blood and
cells; Medical diagnostic services; medical treatment
services; provision of information and data for diagnosis
and medical treatment.
7.
OPHTHALMIC LENS HAVING MORPHED SINUSOIDAL PHASE SHIFT STRUCTURES
An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature and a plurality of morphed sinusoidal phase shift structures. The base curvature may correspond to a base optical power of the ophthalmic lens, and the morphed sinusoidal phase shift structures may be configured to extend depth of focus of the ophthalmic lens at intermediate or near viewing distances.
The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations. Collection and preservation of biological tissue, blood and
cells; Medical diagnostic services; medical treatment
services; provision of information and data for diagnosis
and medical treatment.
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer e-commerce software to allow users to
perform electronic business transactions via a global
computer network in the field of ophthalmic products;
downloadable software for ordering contact lenses, contact
lens care and eye care products; contact lenses. Online retail and wholesale store services featuring contact
lenses, contact lens care and eye care products; Business
management and business administration for eye care
professionals; providing office functions for eye care
professionals. Providing temporary use of non-downloadable computer
e-commerce software to allow users to perform electronic
business transactions via a global computer network in the
field of ophthalmic products; Platform as a service (PaaS)
featuring computer software platforms for ordering contact
lenses, contact lens care and eye care products; software as
a service (SaaS) services featuring software for use of sale
of contact lenses, contact lens care and eye care products.
Projection of visible, non-treatment light onto an eye to illuminate specific areas of the surgical field is disclosed herein. A surgical system may include a surgical console; a microscope communicatively coupled to the surgical console; a camera communicatively coupled to the surgical console; and a projector operable to project light onto an eye. The projector may be communicatively coupled to the surgical console. A method for light projection may include collecting information from an eye using a camera; determining the light projection based, at least in part, on the collected information; and projecting visible, non-treatment light onto the eye using a projector.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
Certain aspects of the present disclosure provide for in-situ intraocular lens (IOL) tilt determination and for providing information associated with the angle of IOL tilt intraoperatively. An example method includes imaging an IOL within a patient's eye via an ophthalmic imaging device, in-situ, after implantation of the IOL within the patient's eye; processing the image of the IOL within the patient's eye to determine an angle of tilt of the IOL; and outputting information associated with the angle of IOL tilt to a user interface.
Certain aspects of the present disclosure provide for in-situ intraocular lens (IOL) tilt determination and for providing information associated with the angle of IOL tilt intraoperatively. An example method includes imaging an IOL within a patient's eye via an ophthalmic imaging device, in-situ, after implantation of the IOL within the patient's eye; processing the image of the IOL within the patient's eye to determine an angle of tilt of the IOL; and outputting information associated with the angle of IOL tilt to a user interface.
A61B 3/125 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer e-commerce software to allow users to
perform electronic business transactions via a global
computer network in the field of ophthalmic products;
downloadable software for ordering contact lenses, contact
lens care and eye care products; contact lenses. Online retail and wholesale store services featuring contact
lenses, contact lens care and eye care products; Business
management and business administration for eye care
professionals; providing office functions for eye care
professionals. Providing temporary use of non-downloadable computer
e-commerce software to allow users to perform electronic
business transactions via a global computer network in the
field of ophthalmic products; Platform as a service (PaaS)
featuring computer software platforms for ordering contact
lenses, contact lens care and eye care products; software as
a service (SaaS) services featuring software for use of sale
of contact lenses, contact lens care and eye care products.
16.
SYSTEMS AND PROCESSES FOR INSERTING AN INTRAOCULAR LENS
Various systems and techniques for inserting an intraocular lens are disclosed. In particular implementations, a system and a technique for inserting an intraocular lens may include the ability to move, in response to a force being applied in a first direction along a longitudinal axis, a first plunger tip along the longitudinal axis and into a delivery cartridge to fold an intraocular lens and move in a second direction along the longitudinal axis in response to the applied force being reduced. The system and the technique may also include the ability to engage a second plunger tip and move, in response to a force being applied in the first direction along the longitudinal axis, the second plunger tip along the longitudinal axis and into the delivery cartridge to insert the intraocular lens.
123455, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.
C07D 487/12 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains three hetero rings
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61P 35/02 - Antineoplastic agents specific for leukemia
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Pharmaceutical preparations for the prevention and treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for the prevention and treatment of immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes; pharmaceutical preparations for the prevention and treatment of cardiovascular diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of metabolic disorders, namely, diabetes, obesity, hyperlipidemia, insulin resistance, metabolic syndrome; anti-inflammatories; pharmaceutical preparations for the prevention and treatment of disorders of the respiratory system; pharmaceutical preparations for the prevention and treatment of disorders of the musculo-skeletal system, namely, connective tissue disease, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries; pharmaceutical preparations for the prevention and treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for use in dermatology, namely, for the prevention and treatment of psoriasis, urticaria, hidradenitis suppurativa, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for use in oncology; pharmaceutical preparations for use in hematology, namely for the treatment of blood disorders; pharmaceutical preparations for use in tissue and organ transplantation; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for prevention and treatment of ocular disorders and diseases; anti-infectives, anti-bacterials, antivirals, anti-biotics, systemic and topical antifungals.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for ophthalmological use; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations.
23.
DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate]hemipentahydrate.
A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
24.
METHODS OF TREATING METABOLIC DISORDERS WITH FGF21 VARIANTS
Provided herein are methods of treating, preventing, and managing metabolic or cardiovascular disorders and methods of reducing cardiovascular risk with FGF21 protein variants, including Fc-FGF21 variant fusion proteins.
A Bernoulli gripper for ophthalmic lenses includes a gripper body with a first cavity corresponding in shape to an optic zone of an ophthalmic lens and a first channel formed within the gripper body. The first channel penetrates the first cavity at one end and includes a first port in the gripper body at another end of the first channel. The first channel is enabled to supply a fluid medium from the first port to the first cavity at a first velocity such that the ophthalmic lens positioned with the optic zone in proximity to the first cavity is subject to a first pressure force against the first cavity by the Bernoulli effect.
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
26.
SELECTIVELY MOVEABLE VALVE ELEMENTS FOR ASPIRATION AND IRRIGATION CIRCUITS
Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.
A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
The present disclosure provides methods for treating an estrogen receptor mediated disease, disorder, or condition in a subject comprising administering to the subject a composition comprising Compound 1 or a pharmaceutically acceptable salt thereof in combination with ribociclib, or a pharmaceutically acceptable salt thereof.
A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
A61K 31/4353 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
The present disclosure provides methods for treating an estrogen receptor mediated disease, disorder, or condition in a subject comprising administering to the subject a composition comprising Compound (1) or a pharmaceutically acceptable salt thereof in combination with alpelisib, or a pharmaceutically acceptable salt thereof.
A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
A61K 31/4353 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A surgical microscope is configured to capture images of an eye of a patient and defines an optical axis. An illumination source is configured to emit a plurality of beams onto the eye of the patient at a plurality of angles relative to the optical axis. A controller is coupled to the surgical microscope and the illumination source, the controller configured to independently control values for illumination parameters for each beam of the plurality of beams to facilitate imaging of the eye of the patient. The illumination parameters may compensate for reflections from the iris, offset of the eye relative to the optical axis, and reflections of ambient light. The illumination parameters may be controlled subject to inputs received from a surgeon or other user.
Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
32.
ILLUMINATION SYSTEM FOR SURGICAL MICROSCOPE WITH TUNABLE COAXIAL AND OBLIQUE BEAMS
A surgical microscope is configured to capture images of an eye of a patient and defines an optical axis. An illumination source is configured to emit a plurality of beams onto the eye of the patient at a plurality of angles relative to the optical axis. A controller is coupled to the surgical microscope and the illumination source, the controller configured to independently control values for illumination parameters for each beam of the plurality of beams to facilitate imaging of the eye of the patient. The illumination parameters may compensate for reflections from the iris, offset of the eye relative to the optical axis, and reflections of ambient light. The illumination parameters may be controlled subject to inputs received from a surgeon or other user.
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer e-commerce software to allow users to perform electronic business transactions via a global computer network in the field of ophthalmic products. Business management and business administration for eye care professionals; providing office functions for eye care professionals. Providing temporary use of non-downloadable computer e-commerce software to allow users to perform electronic business transactions via a global computer network in the field of ophthalmic products.
34.
METHODS AND SYSTEMS FOR EHNANCED OPHTHALMIC VISUALIZATION
In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for enhanced ophthalmic visualization. A plurality of images corresponding to different portions of the electromagnetic spectrum are obtained and combined, such as by pixel-wise subtraction to obtain a combined image. The images may be weighted with weights selected to enhance visualization of features, such as layers of the retina or features corresponding to pathologies. The combined image may be processed, such as by a machine learning model, to extract features.
The present disclosure provides a system that may receive first sensor data associated with first measurements of multiple components of respective multiple medical systems; may determine first one or more classifiers based at least on first user input; may receive second sensor data associated with second measurements of the multiple components; may determine, based at least on the first one or more classifiers and based at least on the second sensor data, at least two services to be provided to respective at least a first two of the multiple medical systems; may receive third sensor data associated with third measurements of multiple components respectively associated with the at least the first two of the multiple medical systems; and may determine, without the first user input and without second user input, second one or more classifiers based at least on the third sensor data.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
36.
SYNTHESIS METHODS AND INTERMEDIATES FOR THE PRODUCTION OF REMIBRUTINIB
This invention relates to novel processes for synthesizing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and to intermediates which are used in such processes.
C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/59 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
A system and method for automated production of a hybrid lens product comprising a lens insert embedded within a lens body. The system preferably includes a first carrier for holding at least one first mold half, a second carrier for holding at least one lens insert, and a third carrier for holding at least one second mold half. The system preferably also includes an automated movement enabling pick-and-place subassembly for positioning a lens insert within a first mold half, and for engaging a second mold half with a first mold half.
Particular embodiments include, by a computing device (500), receiving one or more wavefront elevation maps for a patient's eye and identifying one or more attributes of the one or more wavefront elevation maps corresponding to vitreous floaters. The one or more attributes may include localized spatial variation of the one or more wavefront elevation maps; temporal variation among a plurality of wavefront elevation maps; and depth information indicating scattering of light from within the vitreous of the patient's eye. A machine learning model (518) may be trained and utilized to characterize vitreous floaters based on the one or more wavefront elevation maps and other patient data. The wavefront elevation maps may be measured using an aberrometer. The aberrometer (102) may be integrated with a LIDAR system (202) to estimate depth of scattered light. A common laser light source may be used for both the aberrometer (102) and the LIDAR system (202).
Systems and methods are disclosed for reducing pulsations in peristaltic pumps. In some examples, a cassette comprises a cassette body and a flexible sheet joined to the cassette body, wherein a transition region of the flexible sheet comprises at least one ridge that has a maximum height at a position that is offset from a center line of a cassette body transition channel. In some examples, a cassette body transition channel comprises side walls that taper toward an active region of the fluid path and/or toward a bottom of the transition channel. An example method of operating a peristaltic pump comprises operating rollers at a higher speed during portions of a revolution that otherwise would result in a lower than average flow rate and at a lower speed during portions of the revolution that otherwise would result in a higher than average flow rate.
A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
F04B 11/00 - Equalisation of pulses, e.g. by use of air vessels; Counteracting cavitation
F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
F04B 43/14 - Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
41.
METHODS AND SYSTEMS FOR EHNANCED OPHTHALMIC VISUALIZATION
In certain embodiments, a system, a computer-implemented method, and computer- readable medium are disclosed for enhanced ophthalmic visualization. A plurality of images corresponding to different portions of the electromagnetic spectrum are obtained and combined, such as by pixel-wise subtraction to obtain a combined image. The images may be weighted with weights selected to enhance visualization of features, such as layers of the retina or features corresponding to pathologies. The combined image may be processed, such as by a machine learning model, to extract features.
In certain embodiments, a system, a computer-implemented method, and computer- readable medium are disclosed for light efficient fluorescence imaging. The retina is flashed with broadband light and returned light is imaged after passing through one or more filters, such as notch filers, low-pass filters, and high-pass filters. Images may be captured with a single camera or at least two cameras, one capturing transmitted light from the filter and the other capturing returned light. Images may be combined by subtraction and/or addition to obtain a combined image representing light within a passband whereas no passband filters are used during imaging.
In certain embodiments, a system, a computer-implemented method, and computer- readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient.
OF THE DISCLOSURE In certain embodiments, a system, a computer-implemented method, and computer- readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient. A single device captures OCT and non-OCT images using (a) a sensor of a first imaging device that is shared with a second imaging device and/or (b) an optical component for directing light form the retina to the first imaging device or the second imaging device.
A system and method for automated production of a hybrid lens product comprising a lens insert embedded within a lens body. The system preferably includes a first carrier for holding at least one first mold half, a second carrier for holding at least one lens insert, and a third carrier for holding at least one second mold half. The system preferably also includes an automated movement enabling pick-and-place subassembly for positioning a lens insert within a first mold half, and for engaging a second mold half with a first mold half.
The present disclosure is directed, in part, to aqueous pharmaceutical solutions comprising benzyl atropine or a pharmaceutically acceptable salt or prodrug thereof, at least one buffer, at least one tonicity agent, and at least one solubilizing agent, processes of preparing an aqueous solution comprising benzyl atropine, the products of such processes, and methods of preventing myopia, treating myopia, reducing myopia progression, or preventing myopia progression in a subject in need thereof, by administering to the eye of the subject a therapeutically effective amount of such an aqueous pharmaceutical solution.
Particular embodiments include, by a computing device, receiving one or more wavefront elevation maps for a patient's eye and identifying one or more attributes of the one or more wavefront elevation maps corresponding to vitreous floaters. The one or more attributes may include localized spatial variation of the one or more wavefront elevation maps; temporal variation among a plurality of wavefront elevation maps; and depth information indicating scattering of light from within the vitreous of the patient's eye. A machine learning model may be trained and utilized to characterize vitreous floaters based on the one or more wavefront elevation maps and other patient data. The wavefront elevation maps may be measured using an aberrometer. The aberrometer may be integrated with a LIDAR system to estimate depth of scattered light. A common laser light source may be used for both the aberrometer and the LIDAR system.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient.
In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for light efficient fluorescence imaging. The retina is flashed with broadband light and returned light is imaged after passing through one or more filters, such as notch filers, low-pass filters, and high-pass filters. Images may be captured with a single camera or at least two cameras, one capturing transmitted light from the filter and the other capturing returned light. Images may be combined by subtraction and/or addition to obtain a combined image representing light within a passband whereas no passband filters are used during imaging.
A vitrectomy probe with combined vibration dampening and attenuating. The probe may include a variety of features to lessen the vibrations felt by a surgeon during a vitrectomy procedure. These may include minimizing the degree of flow restriction through a housing that facilitates cutter reciprocation by way of air pressure. Further, utilizing softer stops at a diaphragm that drives the cutter reciprocation may be of benefit as is strategically lessening compressive forces by seals at an extension tube coupled to the diaphragm where possible. The use of a softer gripping component that is actually held by the surgeon may be of benefit in terms of vibration attenuation.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and gene therapy products in the
nature of injectable biologic preparations for genetic,
neurological, motor neuron, or neuromuscular diseases,
disorders and conditions; pharmaceutical preparations and
gene therapy products in the nature of biological
preparations containing genetic materials for treating
spinal muscular atrophy, loss of motor neurons, muscle
degeneration, muscle weakness, and paralysis; gene therapy
preparations in the nature of biological preparations
containing genetic materials for sustained survival motor
neuron protein expression.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and gene therapy products in the
nature of injectable biologic preparations for genetic,
neurological, motor neuron, or neuromuscular diseases,
disorders and conditions; pharmaceutical preparations and
gene therapy products in the nature of biological
preparations containing genetic materials for treating
spinal muscular atrophy, loss of motor neurons, muscle
degeneration, muscle weakness, and paralysis; gene therapy
preparations in the nature of biological preparations
containing genetic materials for sustained survival motor
neuron protein expression.
54.
SYSTEM FOR IMAGING AND DIAGNOSIS OF RETINAL DISEASES
In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient. A single device captures OCT and non-OCT images using (a) a sensor of a first imaging device that is shared with a second imaging device and/or (b) an optical component for directing light form the retina to the first imaging device or the second imaging device.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
According to certain embodiments, a surgical cassette for an ophthalmic surgical system comprises an irrigation conduit that is in fluid communication with a handpiece and carries fluid toward a surgical site. An aspiration conduit is in fluid communication with the handpiece and carries fluid away from the surgical site. An aspiration pump creates a vacuum pressure in the aspiration conduit to draw fluid through the aspiration conduit towards a drain reservoir. A reservoir couples with a pressure-vacuum source to manage the reservoir pressure. A valve is in fluid communication with the aspiration conduit and the reservoir, and provides one or more channels between the aspiration conduit and the reservoir. Each sensor detects a pressure associated with the surgical site. A computer controls the valve in response to the pressure detected by the one or more pressure sensors to mitigate a pressure or volume change.
A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
Apparatus and methods are described which guide a surgeon in performing a reconstructive or cosmetic procedure. The apparatus and methods utilize three-dimensional presentations of the target surgical site incorporating one or more virtual surgical guides which help attain proper alignment and orientation of the post-surgical outcome.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
57.
LOW PROFILE OPTICAL SYSTEMS FOR SURGICAL PROCEDURES
The present disclosure generally relates to optical systems for surgical procedures, and more particularly, to optical relay systems for visualization systems used during ophthalmic microsurgical procedures. The optical systems described herein provide improved ergonomics for surgeons, as such systems facilitate a low-height microscope camera that enables a surgeon to see over the camera to a display screen or other monitor placed in an ergonomically advantageous position for ophthalmic procedures. Such optical systems also provide improved performance, as the total magnification of the optical head may be split between multiple lens barrels, thereby creating high resolution images that enables surgeons to see ophthalmic anatomies more clearly. Even further, such optical systems proffer improved manufacturability, with reduced weight and manufacturing cost, as the lens barrels may have fixed focal lengths for utilization with digital magnification mechanisms.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and gene therapy products in the
nature of injectable biologic preparations for genetic,
neurological, motor neuron, or neuromuscular diseases,
disorders and conditions; pharmaceutical preparations and
gene therapy products in the nature of biological
preparations containing genetic materials for treating
spinal muscular atrophy, loss of motor neurons, muscle
degeneration, muscle weakness, and paralysis; gene therapy
preparations in the nature of biological preparations
containing genetic materials for sustained survival motor
neuron protein expression.
59.
Low Profile Optical Systems for Surgical Procedures
The present disclosure generally relates to optical systems for surgical procedures, and more particularly, to optical relay systems for visualization systems used during ophthalmic microsurgical procedures. The optical systems described herein provide improved ergonomics for surgeons, as such systems facilitate a low-height microscope camera that enables a surgeon to see over the camera to a display screen or other monitor placed in an ergonomically advantageous position for ophthalmic procedures. Such optical systems also provide improved performance, as the total magnification of the optical head may be split between multiple lens barrels, thereby creating high resolution images that enables surgeons to see ophthalmic anatomies more clearly. Even further, such optical systems proffer improved manufacturability, with reduced weight and manufacturing cost, as the lens barrels may have fixed focal lengths for utilization with digital magnification mechanisms.
G03B 35/10 - Stereoscopic photography by simultaneous recording having single camera with stereoscopic-base-defining system
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G02B 15/14 - Optical objectives with means for varying the magnification by axial movement of one or more lenses or groups of lenses relative to the image plane for continuously varying the equivalent focal length of the objective
60.
GENERATION OF MULTISPECTRAL IMAGING INFORMATION USING ANALYTICAL MULTISPECTRAL IMAGING
In certain embodiments, a system, a computer-implemented method, and computer-readable medium for generating multispectral imaging (MSI) based on performing an analytical MSI operation are described. The analytical MSI operation includes synchronizing a scan of a target by a broadband imaging device with a generation of a plurality of light signals, from a plurality of broadband illumination sources, directed towards the target. A set of spectral information associated with the target is generated, based on the scan of the target with the broadband imaging device. A set of multispectral imaging (MSI) information associated with the target is generated, based on performing an MSI operation using at least the set of spectral information. Ophthalmic information is determined based on the set of MSI information.
In certain embodiments, an ophthalmic system and computer-implemented method for automatically initializing an image guided surgery are described. The initialization includes monitoring a scene using multiple images captured by a first imaging device. An eye of a user is detected within a first image of the multiple images. In response to detecting the eye of the user, a registration procedure is initiated with the first image and a reference image of the eye of the user to generate a set of transformation information. A set of overlay content is generated based on the set of transformation information. The set of overlay content includes a transformed first image or a transformed reference image. Overlay content is presented onto the scene via a second imaging device.
Particular embodiments disclosed herein provide an alignment guide for aligning a toric IOL during surgery. An image with a reference axis is obtained, such as from a digital microscope, and processed, such as using an autoencoder, to label alignment marks on the IOL and possibly other features of the IOL. The label is processed, such as using a logistic regression model, to estimate an IOL axis of the IOL intersecting the alignment marks. An output image is generated from the image that has superimposed thereon guides to a surgeon, such as a line representing the IOL axis, a rotation direction indicator, and a number or other representation of a difference between the reference axis and the IOL axis. Tracking of features of the IOL may be performed across multiple images to predict the location of features not represented in a particular image.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations. Computer software; Computer application (software); computer
software for data processing; electronic apparatus,
electronic equipment, software, programs and systems for the
capture, collection, conversion, analysis, communication,
processing, reception, recording, storage and/or
transmission of data, images and information; mechanisms for
data processing equipment, computers; data sets, recorded or
downloadable; electronic apparatus, electronic equipment,
software, programs and systems for the conversion, analysis,
processing, storage and transmission of artificial
intelligence; artificial intelligence and machine learning
software for statistical analysis, consultancy and
reporting; software for analytics in the fields of public
health, healthcare, pharmaceuticals, biotechnology,
biomedical research and development, clinical trials;
computer software for database integration; computer
software for creating searchable databases of information
and data; computer software featuring electronic computer
databases of medical research data, clinical trial data,
patient information and medical industry stakeholder
information; computer software for accessing data and
information related to patient medical information, medical
research data and clinical trial data and for controlling
and managing data and information related to medical
research data, patient medical information and clinical
trial data; computer software platforms for integrating
clinical and non-clinical patient and medical data; computer
software to enable sharing of data and comments among users;
data communication apparatus for transmitting data and
information to databases; downloadable software in the
nature of mobile applications; all the aforesaid goods to be
used in the medical and healthcare fields. Medical apparatus and instruments.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and gene therapy products in the
nature of injectable biologic preparations for genetic,
neurological, motor neuron, or neuromuscular diseases,
disorders and conditions; pharmaceutical preparations and
gene therapy products in the nature of biological
preparations containing genetic materials for treating
spinal muscular atrophy, loss of motor neurons, muscle
degeneration, muscle weakness, and paralysis; gene therapy
preparations in the nature of biological preparations
containing genetic materials for sustained survival motor
neuron protein expression.
This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
The invention is related to a cost-effective method for making a coated contact lens having a hydrogel coating thereon. A method of the invention involves heating a contact lens precursor having carboxylic acid groups on and/or near its surface in an aqueous solution in the presence of a hydrophilic copolymer that comprises monomeric units of (a) at least one epoxy-containing vinylic monomer, (b) at least one amino-containing vinylic monomer having a primary or secondary amino group, (c) at least one polyethyleneglycol-containing vinylic monomer, and (d) at least one phosphorylcholine-containing vinylic monomer, at a temperature from about 100° C. to about 140° C. for at least 30 minutes, thereby forming a hydrogel coating on the contact lens precursor. Such a method can be advantageously implemented directly in a sealed lens package during autoclave.
B29D 11/00 - Producing optical elements, e.g. lenses or prisms
C08F 20/06 - Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
67.
GENERATION OF MULTISPECTRAL IMAGING INFORMATION USING ANALYTICAL MULTISPECTRAL IMAGING
In certain embodiments, a system, a computer-implemented method, and computer-readable medium for generating multispectral imaging (MSI) based on performing an analytical MSI operation are described. The analytical MSI operation includes synchronizing a scan of a target by a broadband imaging device with a generation of a plurality of light signals, from a plurality of broadband illumination sources, directed towards the target. A set of spectral information associated with the target is generated, based on the scan of the target with the broadband imaging device. A set of multispectral imaging (MSI) information associated with the target is generated, based on performing an MSI operation using at least the set of spectral information. Ophthalmic information is determined based on the set of MSI information.
Certain aspects of the present disclosure provide techniques for performing surgical ophthalmic procedures, such as cataract surgeries. An example method of determining one or more intraocular lens (IOL) parameters for an IOL to be used in a cataract surgery procedure includes generating, using a fused machine learning model, recommendations including one or more IOL parameters for the IOL to be used in the cataract surgery based, at least in part, on first predicted lens behavior for each of one or more IOLs by an emulated finite element analysis (EFEA) model and the second predicted lens behavior for each of the one or more IOLs by an IOL power calculator (IPC) machine learning model.
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
69.
TREATMENT OF AUTOIMMUNE DISORDERS USING CHIMERIC ANTIGEN RECEPTOR THERAPY
The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods, and therapeutic uses thereof for treating autoimmune diseases or disorders.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
Certain embodiments herein disclose a cannula assembly (200). The cannula assembly (200) comprises a cannula (210), having a proximal end (214) and a distal end (218). The cannula (210) comprises a head (212) at the proximal end (214), the head (212) having one or more wings (236a-c). The cannula (210) also comprises a hollow rod (216) extending from the head (212) to the distal end (218). The cannula assembly (200) also comprises a hub (250) couplable to the head (212) and having a housing (252) with an inner wall (259). The inner wall (259) comprises an undercut (264), and one or more distal ends (239a-c) of the corresponding one or more wings (236a-c) are configured to fit into the undercut (264) and couple the hub (250) to the head (212) upon insertion of the head (212) into the hub (250).
Certain aspects of the present disclosure provide techniques for performing surgical ophthalmic procedures, such as cataract surgeries. An example method of determining one or more intraocular lens (IOL) parameters for an IOL to be used in a cataract surgery procedure includes generating, using a fused machine learning model, recommendations including one or more IOL parameters for the IOL to be used in the cataract surgery based, at least in part, on first predicted lens behavior for each of one or more IOLs by an emulated finite element analysis (EFEA) model and the second predicted lens behavior for each of the one or more IOLs by an IOL power calculator (IPC) machine learning model.
Particular embodiments disclosed herein provide an apparatus for performing optometric measurements includes an optical coherence tomography (OCT) imaging system configured to output scanned parallel laser beams across a patient's eye. A line in the OCT image is identified, the line representing a retina of the patient's eye. A shape of the line is then used by the refractive error calculator to measure refractive error of the patient's eye. The height of the line due to curvature indicates degree of myopia or hyperopia. More complex curvature of the line corresponds to higher order aberrations. OCT images for a plurality of section planes may be used to calculate a wavefront elevation map.
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
The present invention relates to the use of mavoglurant in the treatment of gambling disorder. The present invention also relates to the use of mavoglurant in the treatment of gaming disorder.
It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.
The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two different linear polylactide-co-glycolide polymers (PLGAs).
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Certain embodiments herein disclose a cannula assembly. The cannula assembly comprises a cannula, having a proximal end and a distal end. The cannula comprises a head at the proximal end, the head having one or more wings. The cannula also comprises a hollow rod extending from the head to the distal end. The cannula assembly also comprises a hub couplable to the head and having a housing with an inner wall. The inner wall comprises an undercut, and one or more distal ends of the corresponding one or more wings are configured to fit into the undercut and couple the hub to the head upon insertion of the head into the hub.
In certain embodiments, an ophthalmic system and computer-implemented method for automatically initializing an image guided surgery are described. The initialization includes monitoring a scene using multiple images captured by a first imaging device. An eye of a user is detected within a first image of the multiple images. In response to detecting the eye of the user, a registration procedure is initiated with the first image and a reference image of the eye of the user to generate a set of transformation information. A set of overlay content is generated based on the set of transformation information. The set of overlay content includes a transformed first image or a transformed reference image. Overlay content is presented onto the scene via a second imaging device.
Particular embodiments disclosed herein provide an apparatus for performing optometric measurements includes an optical coherence tomography (OCT) imaging system configured to output scanned parallel laser beams across a patient's eye. A line in the OCT image is identified, the line representing a retina of the patient's eye. A shape of the line is then used by the refractive error calculator to measure refractive error of the patient's eye. The height of the line due to curvature indicates degree of myopia or hyperopia. More complex curvature of the line corresponds to higher order aberrations. OCT images for a plurality of section planes may be used to calculate a wavefront elevation map.
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
82.
DRY EYE MITIGATION FOR OCULAR ABERROMETRY SYSTEMS AND METHODS
Techniques are disclosed for systems and methods to provide dry eye and/or tear film hydration monitoring in the context of ocular aberrometry. An ocular aberrometry system includes a wavefront sensor configured to provide wavefront sensor data associated with an optical target monitored by the ocular aberrometry system and a logic device configured to communicate with the wavefront sensor. The logic device is configured to receive ocular aberrometry output data including at least the wavefront sensor data provided by the wavefront sensor, determine a tear film hydration state associated with the optical target based, at least in part, on the received ocular aberrometry output data, and generate user feedback corresponding to the determined tear film hydration state based, at least in part, on the received aberrometry output data and/or the determined tear film hydration state.
The present disclosure is directed, in part, to aqueous pharmaceutical solutions comprising benzyl atropine or a pharmaceutically acceptable salt or prodrug thereof, at least one buffer, at least one tonicity agent, and at least one solubilizing agent, processes of preparing an aqueous solution comprising benzyl atropine, the products of such processes, and methods of preventing myopia, treating myopia, reducing myopia progression, or preventing myopia progression in a subject in need thereof, by administering to the eye of the subject a therapeutically effective amount of such an aqueous pharmaceutical solution.
A61K 47/44 - Oils, fats or waxes according to two or more groups of ; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Particular embodiments disclosed herein provide an alignment guide for aligning a toric IOL during surgery. An image with a reference axis is obtained, such as from a digital microscope, and processed, such as using an autoencoder, to label alignment marks on the IOL and possibly other features of the IOL. The label is processed, such as using a logistic regression model, to estimate an IOL axis of the IOL intersecting the alignment marks. An output image is generated from the image that has superimposed thereon guides to a surgeon, such as a line representing the IOL axis, a rotation direction indicator, and a number or other representation of a difference between the reference axis and the IOL axis. Tracking of features of the IOL may be performed across multiple images to predict the location of features not represented in a particular image.
An ophthalmic device includes an optic including an optic axis and a haptic structure coupled with the optic. The haptic structure includes an inner ring comprising a plurality of hinges such that portions of the inner ring reside at different radii from the optic axis. The haptic structure further includes a first loop extending from the inner ring and having two points of connection to the inner ring and a second loop extending from the inner ring and having two points of connection to the inner ring. The second loop is oriented opposite the first loop.
A stereoscopic imaging platform includes a stereoscopic camera configured to record left and right images of a target site. A robotic arm is operatively connected to the stereoscopic camera, the robotic arm being adapted to selectively move the stereoscopic camera relative to the target. The stereoscopic camera includes a lens assembly having at least one lens and defining a working distance. The lens assembly has at least one focus motor adapted to move the at least one lens to selectively vary the working distance. A controller is adapted to selectively execute one or more automatic focusing modes for the stereoscopic camera. The controller has a processor and tangible, non-transitory memory on which instructions are recorded. The automatic focusing modes include a target locking mode. The target locking mode is adapted to maintain a focus of the at least one stereoscopic image while the robotic arm is moving the stereoscopic camera.
H04N 23/959 - Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging by adjusting depth of field during image capture, e.g. maximising or setting range based on scene characteristics
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
H04N 13/204 - Image signal generators using stereoscopic image cameras
H04N 13/296 - Synchronisation thereof; Control thereof
H04N 23/67 - Focus control based on electronic image sensor signals
H04N 23/695 - Control of camera direction for changing a field of view, e.g. pan, tilt or based on tracking of objects
88.
3D PRINTING OF AN INTRAOCULAR LENS HAVING SMOOTH, CURVED SURFACES
A continuous additive fabrication system comprises a bath of photopolymer resin and a light source assembly having a light source and a motorized variable aperture. The light source assembly is operable to generate a focus point in the bath of photopolymer resin, the shape of the focus point at a curing plane within the bath of photopolymer resin corresponding to the shape of the motorized variable aperture. The continuous additive fabrication system further comprises a platform configured to support a build object and a drive mechanism (coupled to at least one of the platform and the light source assembly) configured to continuously move the curing plane through the bath of photopolymer resin. A size and/or shape of the motorized variable aperture is changed while the curing plane in continuously moved through the bath of photopolymer resin.
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
An ophthalmic surgical system for monitoring incision performance includes a laser device, a camera, and a computer. laser device delivers a laser beam with a laser setting energy towards a target to create optical breakdowns in the target. The camera generates images of the optical breakdowns in the target. The computer instructs the laser device to create the optical breakdowns in the target to yield a test pattern. The test pattern comprises regions of optical breakdowns, where each region was created with a different laser setting energy. From the images, the computer identifies a lowest energy region with substantially continuous optical breakdowns, and designates the laser setting energy used to create the identified region as a threshold energy.
Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
A robotic imaging system includes a body with a head unit, a robotic arm and a coupling plate. A camera is positioned in the head unit and configured to record one or more images of a target site. The camera is operatively connected to one or more handles. A plurality of sensors is configured to transmit sensor data. The sensors include at least one primary sensor configured to detect respective force and/or respective torque applied at the body and at least one auxiliary sensor configured to detect the respective force and/or the respective torque applied at the one or more handles. A controller is configured to receive the sensor data and execute a contact management mode, including determining a contact location of the body with an external object based in part on the sensor data and determining a reverse trajectory for moving the body away from the contact location.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
