Disclosed herein is a wearable device (100) for detecting an analyte in tissue of a human or animal subject, the wearable device (100) comprising a holding portion (104) for securing the wearable device (100) to a body part (106) of the subject, said holding portion (104) being configured to be arranged around the body part (106) of the subject so as to extend circumferentially around the body part (106) at least in part, wherein the wearable device (100) comprises a measurement body (16) and actuated means (110, 206, 208) for temporarily increasing a contact pressure between the measurement body (16) and the skin of the subject.
An apparatus (10) for analyzing a material (12) comprising at least one analyte, said apparatus comprising a measurement body (16) having a contact surface (14) suitable to be brought in thermal contact or pressure-transmitting contact with said material (12), an excitation radiation source (26) configured for irradiating excitation radiation (18) into the material (12) to be absorbed therein, and a detection device for detecting a physical response of the measurement body to heat or a pressure wave received from said material (12) upon absorption of said excitation radiation (18) and for generating a response signal indicative of the degree of absorption of excitation radiation, wherein a protrusion (80) is provided, said protrusion having a front surface (82) facing said material (12) and being in contact with the material when the material is brought in contact with the contact surface, and wherein said excitation radiation (18) is irradiated into the material (12) through said front surface (82) of said protrusion (80), wherein said protrusion (80) is formed on said contact surface (14) of said measurement body (16), or wherein said measurement body (16) forms said protrusion or a part of said protrusion, in which said contact surface (14) of said measurement body (16) forms at least a part of said front surface of said protrusion and is elevated with respect to a surrounding structure.
An apparatus (10) for analyzing a material (12) comprising at least one analyte, said apparatus comprising a measurement body (16) having a contact surface (14) suitable to be brought in thermal contact or pressure-transmitting contact with said material (12), an excitation radiation source (26) configured for irradiating excitation radiation (18) into the material (12) to be absorbed therein, and a detection device for detecting a physical response of the measurement body to heat or a pressure wave received from said material (12) upon absorption of said excitation radiation (18) and for generating a response signal indicative of the degree of absorption of excitation radiation, wherein on said contact surface (14), a protrusion (80) is formed, said protrusion having a front surface (82) facing said material (12) and being in contact with the material when the material is brought in contact with the contact surface, and wherein said excitation radiation (18) is irradiated into the material (12) through said front surface (82) of said protrusion (80).
Disclosed herein is an apparatus (10) for analyzing a material (12) comprising at least one analyte, said apparatus (10) comprising a measurement body (16) having a contact surface (14) suitable to be brought in thermal contact or pressure-transmitting contact with said material (12), an excitation radiation source configured for irradiating excitation radiation into the material (12) to be absorbed therein, and a detection light source for generating a detection light beam (22) travelling through at least a portion of said measurement body (16) or a component included in said measurement body, wherein said detection light beam is directed to be totally or partially reflected at said contact surface (14), wherein said contact surface (14) of the measurement body is curved in at least one principal direction in the area where the detection light beam (22) is reflected.
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/41 - Refractivity; Phase-affecting properties, e.g. optical path length
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
5.
METHOD AND APPARATUS FOR ANALYTE MEASUREMENT INCLUDING REAL-TIME QUALITY ASSESSMENT AND IMPROVEMENT
A method of analyzing a material (12) comprising at least one analyte, wherein analyte-wavelength-specific measurements are interspersed with reference measurements (80), and wherein response signals obtained for the reference measurements (80) are used for one or more of calibrating an excitation radiation source (26) for generating said excitation radiation, calibrating said detection device, recognizing a variation in the measurement conditions by comparing results of individual reference measurements (80), adapting the analyte measurement procedure (78) with respect to one or more of the entire duration thereof, the absolute or relative duration of analyte-wavelength-specific measurements for a given analyte-characteristic-wavelength, or terminating and/or restarting the analyte measurement procedure, and adapting the analysis carried out in the analyzing step.
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G01N 21/41 - Refractivity; Phase-affecting properties, e.g. optical path length
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
6.
METHOD AND APPARATUS FOR ANALYTE MEASUREMENT INCLUDING MATERIAL STATUS ANALYSIS
A method of analyzing a material (12) comprising at least one analyte, said method comprising a material status analyzing procedure (76), in which a present status of the material is analyzed, wherein based on a result of said material status analyzing procedure (76), at least one of a selection of analyte-characteristic-wavelengths used during an analyte measurement procedure (78), an absolute time or a relative time proportion of use of analyte-characteristic-wavelengths during said analyte measurement procedure (78), an individual excitation radiation intensity, or a relative weight given to the wavelengths in the analysis, a selection of analyte-characteristic-wavelengths to be used simultaneously during said analyte measurement procedure (78), and a selection of one or more main frequencies of the modulation of said excitation radiation (18) intensity to be used during said analyte measurement procedure (78) is determined.
A method of analyzing a material (12) comprising at least one analyte, wherein analyte-wavelength-specific measurements are interspersed with reference measurements (80), and wherein response signals obtained for the reference measurements (80) are used for one or more of calibrating an excitation radiation source (26) for generating said excitation radiation, calibrating said detection device, recognizing a variation in the measurement conditions by comparing results of individual reference measurements (80), adapting the analyte measurement procedure (78) with respect to one or more of the entire duration thereof, the absolute or relative duration of analyte-wavelength-specific measurements for a given analyte-characteristic-wavelength, or terminating and/or restarting the analyte measurement procedure, and adapting the analysis carried out in the analyzing step.
A method of analyzing a material (12) comprising at least one analyte, said method comprising an analyte measurement procedure (78), in which excitation radiation (18) is irradiated into the material (12) to be absorbed therein, wherein the intensity of said excitation radiation is time-modulated, wherein the time modulation of said intensity of said excitation radiation (18) is chosen such that an envelope of the intensity is asymmetrical or wherein time modulation of said intensity of said excitation radiation (18) is chosen such that the envelope of the intensity is approximately harmonic such that in a Fourier decomposition of the intensity of the excitation radiation, of the total intensity associated with the dominant frequency and the 1stto 9th harmonics, at least 95% is associated with the dominant frequency and at least 97%, preferably at least 98% is associated with the dominant frequency and first harmonic.
A method of analyzing a material (12) comprising at least one analyte, said method comprising a material status analyzing procedure (76), in which a present status of the material is analyzed, wherein based on a result of said material status analyzing procedure (76), at least one of a selection of analyte-characteristic-wavelengths used during an analyte measurement procedure (78), an absolute time or a relative time proportion of use of analyte-characteristic-wavelengths during said analyte measurement procedure (78), an individual excitation radiation intensity, or a relative weight given to the wavelengths in the analysis, a selection of analyte-characteristic-wavelengths to be used simultaneously during said analyte measurement procedure (78), and a selection of one or more main frequencies of the modulation of said excitation radiation (18) intensity to be used during said analyte measurement procedure (78) is determined.
The invention relates to a system for analysing a substance, the system having: a measuring body (1, 1a), which has a measuring surface (2) and, in order to carry out the measuring process, can be brought, at least partially into contact, in the vicinity of its measuring surface, with the substance (3); a laser system (4), in particular comprising a quantum cascade laser (QCL), a tunable QCL, and/or comprising a laser array, preferably an array of QCLs, for generating one or more excitation beams (10) with different wavelengths, preferably in the infrared or middle infrared spectral range, which is directed onto the substance (3); and a detection device (5, 6, 7) which is at least partially integrated in the measuring body (1, 1a) or connected thereto, said detection device comprising: · a source (5) for coherent detection light (11) and • a first optical waveguide structure (6) which can be or is connected to the source for the detection light and which guides the detection light, the refraction index of said optical waveguide structure being dependent, at least in sections, on the temperature and/or pressure, the first optical waveguide structure having at least one section (9) in which the light intensity depends on a phase shift of detection light in at least part of the first optical waveguide structure (6) as a result of a change in temperature or pressure.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
The invention relates to a device for analyzing a substance, comprising: - a measurement body (1, 1a), which has a measurement surface (2) and is to be brought at least in part into contact with the substance (3) in the region of the measurement surface for the purpose of measuring; a laser device (4), particularly having a quantum cascade laser (QCL), a tunable QCL and/or a laser array, preferably an array of QCLs, in order to generate one or more excitation beams (10) at different wavelengths, preferably in the infrared or medium infrared spectral range, which is directed to the substance (3); and a detection apparatus (5, 6, 7) which is integrated at least in part in the measurement body (1, 1a) or connected thereto and comprises the following: • a source (5) for coherent detection light (11) and • a first optical waveguide structure (6) which can be or is connected to the source for the detection light, which guides the detection light, and has a refractive index which is dependent at least in portions on the temperature and/or pressure, wherein the first optical waveguide structure has at least one portion (9) in which the light intensity depends on a phase shift of detection light in at least one part of the first optical waveguide structure (6) due to a change in temperature or pressure.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
patents
