03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Non-medicated cosmetics; Toiletry preparations. Pharmaceuticals; Sanitary preparations for medical purposes; Disinfectants and antiseptics; Anti-bacterial preparations.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary supplemental drinks; dietary supplements for humans; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical use; effervescent vitamin tablets; gastro-intestinal treatment preparations; pharmaceutical preparations for treating allergies; preparations for treating colds
5.
SULFATED PEPTIDES FOR CHEMOKINE RECEPTOR ANTIBODY GENERATION
The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells. Also provided are medical uses of the inventive antibodies or conjugates and/or treatment methods comprising the administration of these antibodies to a patient or subject, either alone or in combination. Biomarkers, stratification methods and diagnostic methods are finally provided to predict or evaluate responsiveness to anti-CCR8 antibody monotherapy or combination therapy. The invention furthermore provides tools and methods for producing the foregoing antibodies, pharmaceutical compositions, diagnostic uses of the antibodies, and kits with instructions for use.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
38 - Telecommunications services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Software used for radiology activity and diagnosis; artificial intelligence software; none of the aforesaid for dental use. Surgical and medical apparatus and instruments; medical devices for radiology activity and diagnosis; none of the aforesaid for dental use. Providing access to medical databases; transmission and reception [transmission] of medical database information via a telecommunication network; telecommunications services for providing access to databases; provision of access to databases on computer networks; provision of access to on-line computer databases; transmission of database information via telecommunication networks; electronic transmission of messages, data and documents; all the aforesaid services being provided or related to the medical field; none of the aforesaid relating to the dental sector. Design and development of software; installation of software, maintenance of software, updating of software, software as a service (SaaS) for use in the medical field; development of software application solutions; software as a service [SaaS] enabling the interpretation of images obtained in the context of medical imaging procedures; providing temporary use of online non-downloadable and/or downloadable software for processing, interpreting and managing data produced by putting into operation medical imaging procedures; scientific research; technological research; engineering services; research in the field of artificial intelligence; advice in the field of technological development; design and development of engineering products; all the aforesaid services being provided or connected with the medical field; none of the aforesaid relating to the dental sector. Medical and health services; medical information; information in the field of health; information services with respect to diagnostic products for medical use; radiology activity assistance services; none of the aforesaid relating to the dental sector.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
38 - Telecommunications services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Software used for radiology activity and diagnosis; artificial intelligence software. Surgical and medical apparatus and instruments; medical devices for radiology activity and diagnosis. Providing access to medical databases; transmission and reception [transmission] of medical database information via a telecommunication network; telecommunications services for providing access to databases; provision of access to databases on computer networks; provision of access to on-line computer databases; transmission of database information via telecommunication networks; electronic transmission of messages, data and documents; all the aforesaid services being provided or related to the medical field. Design and development of software; installation of software, maintenance of software, updating of software, software as a service (SaaS) for use in the medical field; development of software application solutions; software as a service [SaaS] enabling the interpretation of images obtained in the context of medical imaging procedures; providing temporary use of online non-downloadable and/or downloadable software for processing, interpreting and managing data produced by putting into operation medical imaging procedures; scientific research; technological research; engineering services; research in the field of artificial intelligence; advice in the field of technological development; design and development of engineering products; all the aforesaid services being provided or connected with the medical field. Medical and health services; medical information; information in the field of health; information services with respect to diagnostic products for medical use; radiology activity assistance services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Chemical preparations for the treatment of seeds; Fertilizers. Preparations for killing weeds; Preparations for destroying vermin; Insecticides; Herbicides; Fungicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Chemical preparations for the treatment of seeds; Fertilizers. Preparations for killing weeds; Preparations for destroying vermin; Herbicides; Fungicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for humans for the treatment of gynecological related diseases, disorders and deficiencies; pharmaceutical preparations for humans for the treatment of hormone related diseases, disorders and deficiencies
[Problem] Provided are a plant growth regulator for turfgrasses and a method for regulating the growth of turfgrasses using the same. [Means to Solve the Problem] Provided are a plant growth regulator for turfgrasses, comprising a compound represented by formula (I) or agriculturally acceptable salts thereof, and a method for regulating the growth of turfgrasses using the same.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Seed preserving substances; Plant growth regulating preparations; Genes of seeds for agricultural production; Fertilizers. Preparations for destroying vermin; Fungicides; Herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Seed preserving substances; Plant growth regulating preparations; Genes of seeds for agricultural production; Fertilizers. Preparations for destroying vermin; Fungicides; Herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Seed preserving substances; Plant growth regulating preparations; Genes of seeds for agricultural production; Fertilizers. Preparations for destroying vermin; Fungicides; Herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Seed preserving substances; Plant growth regulating preparations; Genes of seeds for agricultural production; Fertilizers. Preparations for destroying vermin; Fungicides; Herbicides.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Nutritional supplements; Dietary supplements; Vitamin and mineral supplements. Computer software platforms, recorded or downloadable; Downloadable software applications for mobile phones.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Nutritional supplements; Dietary supplements; Vitamin and mineral supplements. Computer software platforms, recorded or downloadable; Downloadable software applications for mobile phones.
This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 31/5355 - Non-condensed oxazines containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings
The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells. Also provided are medical uses of the inventive antibodies or conjugates and/or treatment methods comprising the administration of these antibodies to a patient or subject, either alone or in combination. Biomarkers, stratification methods and diagnostic methods are finally provided to predict or evaluate responsiveness to anti-CCR8 antibody monotherapy or combination therapy. The invention furthermore provides tools and methods for producing the foregoing antibodies, pharmaceutical compositions, diagnostic uses of the antibodies, and kits with instructions for use.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells. Also provided are medical uses of the inventive antibodies or conjugates and/or treatment methods comprising the administration of these antibodies to a patient or subject, either alone or in combination. Biomarkers, stratification methods and diagnostic methods are finally provided to predict or evaluate responsiveness to anti-CCR8 antibody monotherapy or combination therapy. The invention furthermore provides tools and methods for producing the foregoing antibodies, pharmaceutical compositions, diagnostic uses of the antibodies, and kits with instructions for use.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti -human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-intemalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells. Also provided are medical uses of the inventive antibodies or conjugates and/or treatment methods comprising the administration of these antibodies to a patient or subject, either alone or in combination. Biomarkers, stratification methods and diagnostic methods are finally provided to predict or evaluate responsiveness to anti-CCR8 antibody monotherapy or combination therapy. The invention furthermore provides tools and methods for producing the foregoing antibodies, pharmaceutical compositions, diagnostic uses of the antibodies, and kits with instructions for use.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
87.
ANTI CCR8 ANTIBODY THERAPY: BIOMARKERS & COMBINATION THERAPIES
The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells. Also provided are medical uses of the inventive antibodies or conjugates and/or treatment methods comprising the administration of these antibodies to a patient or subject, either alone or in combination. Biomarkers, stratification methods and diagnostic methods are finally provided to predict or evaluate responsiveness to anti-CCR8 antibody monotherapy or combination therapy. The invention furthermore provides tools and methods for producing the foregoing antibodies, pharmaceutical compositions, diagnostic uses of the antibodies, and kits with instructions for use.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
provision of access to a global (Internet) or local network of computers; access services to databases rendered by computer and telematics servers in a client-server architecture network. Medical services; hygienic and beauty care for human beings.
