CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
ECOLE CENTRALE DE NANTES (France)
ECOLE SUP CHIMIE PHYS ELECTRONIQ LYON (France)
HEALSHAPE (France)
Inventor
Marquette, Christophe
Cherblanc, Audrey
Dos Santos, Morgan
Vidal, Luciano
Petiot, Emma
Chastagnier, Laura
Thepot, Amélie
Godet, Baptiste
Abstract
Three-dimensional body implants including a hydrogel, which includes cross-linked alginate and gelatin, and in particular breast implants. The hydrogel of the implants has a mechanical strength of 1 kPa to 1000 kPa, and the hydrogel of the implants may further include fibrinogen. The implants include a porous zone, and the implants are acellular, i.e., free of cells during their manufacture.
B29C 71/00 - After-treatment of articles without altering their shape; Apparatus therefor
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
2.
METHOD FOR TREATING AND PROGNOSING CANCER LIKE GLIOBLASTOMA
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
ECOLE CENTRALE DE NANTES (France)
INSTITUT DE CANCÉROLOGIE DE L'OUEST (France)
Inventor
Cartron, Pierre-François
Bougras-Cartron, Gwenola
Serandour, Aurélien
Briand, Joséphine
Abstract
The present invention relates the treatment and prognostic of cancer like glioblastoma. Here, the inventors focused their study on the impact of presence of N6-adenosine methylation in miRNA-200b-3p in samples of patients suffering from glioblastoma multiforme (GBM). Their study was particularly focused on the impact of miRNA-200b-3p and its adenosine methylation on the expression of XIAP. XIAP acts as an anti-apoptotic protein via the inhibition of caspase-3 and -7 activation and high XIAP expression is associated with a poor survival in several solid tumors. Thus, the miR-200b-3p-mediated repression of XIAP mRNA expression appears as a mechanism governing the caspase-3 and -7 activity and the apoptosis. In theory, in the presence of miR-200b-3p, XIAP mRNA expression is repressed and caspase-3 and -7 can be activated to promote apoptosis. Thus, the present invention relates to an in vitro method for determining the prognosis of the survival time of a patient suffering from a cancer comprising the steps consisting of i) determining the expression level of the miR-200b-3p and/or the N6-adenosine methylated miRNA-200b-3p (miR-200b-3p m6A) in a sample from said patient and to the N6-adenosine methylated miRNA-200b-3p (miR-200b-3p m6A) for use in the treatment of a cancer in a subject in need thereof.
A61P 25/00 - Drugs for disorders of the nervous system
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
3.
METHOD AND DEVICE FOR ADDITIVE MANUFACTURING BY AGGLOMERATION OF A GRANULAR MATERIAL
A method for manufacturing a structure from a granular material, called sand, in particular a mold. A layer of sand is deposited. The layer of sand is selectively agglomerated by spraying, using a spray nozzle, an inorganic binder having an M2SiO3 type (meta)silicate dissolved in a solvent. Prior to the spraying, the inorganic binder is heated to a temperature to confer on it a viscosity less than 0.2 Pa·s. A device for implementing the method is provided.
B22C 1/18 - Compositions of refractory mould or core materials; Grain structures thereof; Chemical or physical features in the formation or manufacture of moulds characterised by the use of binding agents; Mixtures of binding agents of inorganic agents
B22C 1/16 - Compositions of refractory mould or core materials; Grain structures thereof; Chemical or physical features in the formation or manufacture of moulds characterised by the use of binding agents; Mixtures of binding agents
B22C 9/02 - Sand moulds or like moulds for shaped castings
B22C 1/02 - Compositions of refractory mould or core materials; Grain structures thereof; Chemical or physical features in the formation or manufacture of moulds characterised by additives for special purposes, e.g. indicators, breakdown additives
B22C 19/04 - Controlling devices specially designed for moulding machines
B22C 5/00 - Machines or devices specially designed for dressing or handling the mould material so far as specially adapted for that purpose
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
A device for depositing a layer of granular material on a deposition surface. The device includes a discharge hopper, a scraper, and a transporter to move the discharge hopper and the scraper relative to the deposition surface. The hopper includes a plurality of discharge holes, aligned in a transverse direction, a top portion and a conical bottom discharge portion. The bottom discharge portion includes two transverse walls that are inclined towards the discharge holes. Each compartment, of a transverse compartmentalization of the discharge portion, includes two walls perpendicular to the transverse walls of the conical bottom discharge portion and inclined towards the discharge holes. Each compartment facing a discharge hole forms a pyramid-shaped conduit in the bottom discharge portion. The consecutive walls of the two compartments being joined at a corner where they meet in the bottom discharge portion.
B33Y 40/00 - Auxiliary operations or equipment, e.g. for material handling
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
A robot to manufacture a part by additive manufacturing using volume elements or voxels. The robot includes a base and a rotary arm having a plurality of effectors for additive manufacturing radially distributed on the arm. A guiding shaft to translationally move the rotary arm by rotation, in a direction parallel to its axis of rotation, and to translationally and rotationally guide the rotary arm relative to the base. A controller to control the action of the effectors for additive manufacturing as a function of the position of the rotary arm in space. A method for implementing the robot is provided.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 50/00 - Data acquisition or data processing for additive manufacturing
B28B 1/00 - Producing shaped articles from the material
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
B29C 64/386 - Data acquisition or data processing for additive manufacturing
B22F 12/00 - Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
A system to adjust and measure an additive manufacturing device via the CLAD method. The system includes a powder spray nozzle and a laser beam passing through the center of the nozzle, and a light source providing a light beam substantially perpendicular a lighting plane. The light source includes a support to position the light source with respect to a material surface. A profile camera is installed such that its optical axis is substantially parallel to the lighting plane. A projector to project a view seen by the center of the nozzle on an optical path and an optical axis of a centering camera is placed on the optical path. A low-power laser shot perforates a target. An acquisition and processing unit collects the images from the two cameras.
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/268 - Arrangements for irradiation using electron beams [EB]
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B05B 7/22 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed electrically, e.g. by arc
G05B 19/401 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control arrangements for measuring, e.g. calibration and initialisation, measuring workpiece for machining purposes
B22F 3/105 - Sintering only by using electric current, laser radiation or plasma
G05B 19/18 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
7.
Device for additive manufacturing by spraying and fusion of powder
A nozzle for the additive manufacturing by spraying and fusion of powder along a hollow tapered stream. The nozzle includes an outer cone, an inner cone, and an intermediate cone. The powder is sprayed into the tapered annular space between the inner surface of the outer cone and the outer surface of the intermediate cone. The outer cone includes two portions detachably assembled along the axis of the cone by an assembler.
B23K 26/00 - Working by laser beam, e.g. welding, cutting or boring
B05B 7/22 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed electrically, e.g. by arc
B05B 12/08 - Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material discharged, of ambient medium or of target
B22F 3/105 - Sintering only by using electric current, laser radiation or plasma
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B05B 15/18 - Arrangements for preventing or controlling structural damage to spraying apparatus or its outlets, e.g. for breaking at desired places; Arrangements for handling or replacing damaged parts for handling or replacing worn parts
B05B 15/14 - Arrangements for preventing or controlling structural damage to spraying apparatus or its outlets, e.g. for breaking at desired places; Arrangements for handling or replacing damaged parts
8.
Assembly method between a part made of metal material and a part made of organic matrix composite material; corresponding parts made of organic matrix composite material and assembly
An assembly method between a part made of metal material and a part made of organic matrix composite material, said method having a step of providing two parts, each including a surface to be welded, and the surface to be welded of said composite part is made up, at least partially, of an exposed portion of at least one metal insert which is partially embedded in said composite part; positioning said surfaces to be welded opposite and separated from each other; and projecting, at high speed, the surface to be welded of the metal part or the exposed portion of the metal insert, onto one another, to obtain high-speed clamping to one another and to obtain a weld between the exposed portion of the metal insert of the composite part and the complementary portion of the surface to be welded.
B29C 65/00 - Joining of preformed parts; Apparatus therefor
B29C 65/64 - Joining a non-plastics element to a plastics element, e.g. by force
B29C 65/72 - Joining of preformed parts; Apparatus therefor by combined operations, e.g. welding and stitching
B23K 20/06 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating by means of high energy impulses, e.g. magnetic energy
B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
B29C 65/02 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure
B23K 31/02 - Processes relevant to this subclass, specially adapted for particular articles or purposes, but not covered by any single one of main groups relating to soldering or welding
A machining method and apparatus for machining a part comprises a machining head and motorized axes comprising a rotary axis for displacing the machining head in a working space. Apparatus comprises a mechanism for positioning a part and holding it in position the working space. The machining head comprises a support for supporting a material shaping tool and a supply device for supplying material.
B23K 26/32 - Bonding taking account of the properties of the material involved
B23K 26/00 - Working by laser beam, e.g. welding, cutting or boring
B23K 26/08 - Devices involving relative movement between laser beam and workpiece
B23P 23/04 - Machines or arrangements of machines for performing specified combinations of different metal-working operations not covered by a single other subclass for both machining and other metal-working operations
B23P 15/00 - Making specific metal objects by operations not covered by a single other subclass or a group in this subclass
B23P 17/00 - Metal-working operations, not covered by a single other subclass or another group in this subclass
B23K 26/34 - Laser welding for purposes other than joining
B21D 22/16 - Spinning over shaping mandrels or formers
B23Q 39/02 - Metal-working machines incorporating a plurality of sub-assemblies, each capable of performing a metal-working operation the sub-assemblies being capable of being brought to act at a single operating station
B23K 37/04 - Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the other main groups of this subclass for holding or positioning work
B23K 37/047 - Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the other main groups of this subclass for holding or positioning work moving work to adjust its position between soldering, welding or cutting steps
G05B 19/4099 - Surface or curve machining, making 3D objects, e.g. desktop manufacturing
Laboratoire Central des Ponts et Chaussees (France)
Inventor
Dannawi, Marwan
Brevet, Pierre
Abstract
Safety equipment for use with prestressing cables as used in civil engineering and building structures, the safety equipment having two principle parts adapted to fit over a cable at a point where the cable interfaces with anchoring members or walls, the safety equipment configured to take over from original anchoring elements in the event of a rupture of the cable.
patents
