Shimadzu Corporation

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G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode 616
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1.

TIME-OF-FLIGHT MASS SPECTROMETER AND TIME-OF-FLIGHT MASS SPECTROMETRY METHOD

      
Application Number 18559166
Status Pending
Filing Date 2021-06-09
First Publication Date 2024-07-18
Owner Shimadzu Corporation (Japan)
Inventor
  • Miyazaki, Yuta
  • Oshiro, Tomoyuki

Abstract

A TOFMS includes flight space formation electrodes, an ion detection unit, voltage switching units to switch a voltage to be applied to the flight space formation electrode from a first voltage for flying ions of a first polarity to a second voltage for flying ions of a second polarity, ion information acquisition units to obtain a time of flight or a m/z of the ions based on a detection result of the ions of the second polarity after the voltage has been switched, a correction information storage unit to store correction information related to a deviation in time of flight or a m/z associated with an elapsed time from the switching timing, and a correction unit to correct the flight time or the m/z according to an elapsed time from the switching timing when the detection result of the ion is obtained using the correction information.

IPC Classes  ?

  • H01J 49/40 - Time-of-flight spectrometers
  • G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof

2.

Antibody Production Assisting Method and Antibody Production Assisting Program

      
Application Number 18560152
Status Pending
Filing Date 2022-03-25
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Motoyama, Kento
  • Yamada, Kaori
  • Kanai, Masaki
  • Suzuki, Takashi

Abstract

An assisting method for assisting production of an antibody includes: acquiring first time-series data corresponding to an amount of metabolite generated as a result of culturing in a small scale a cell line for producing the antibody under a predetermined culture condition; acquiring second time-series data corresponding to an amount of metabolite generated as a result of culturing in a large scale the cell line under the predetermined culture condition; specifying a difference between the first time-series data and the second time-series data; specifying a target metabolite derived from the difference; and generating display data based on the target metabolite.

IPC Classes  ?

  • G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

3.

Mass Spectrometer and Mass Spectrometry Method

      
Application Number 18579781
Status Pending
Filing Date 2022-03-25
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Mitsui, Kazutaka
  • Takahashi, Hidenori
  • Miyazaki, Yuta

Abstract

A mass spectrometry method in which a precursor ion is introduced into a reaction chamber (step 2), a radical is generated in a radical generation chamber, the precursor ion is irradiated with the radical to generate a product ion (step 15), and a mass of the product ion is measured (step 16) includes, when generating the radical, introducing a material gas into the radical generation chamber (steps 5 and 8), supplying radio-frequency power to the material gas simultaneously with or after introducing the precursor ion into the reaction chamber (steps 5 and 8), and supplying an electron to the material gas in a state where the radio-frequency power is supplied to generate plasma emission, and irradiating the material gas with the plasma emission to generate the radical (steps 6 and 9).

IPC Classes  ?

  • H01J 49/10 - Ion sources; Ion guns
  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/02 - Particle spectrometers or separator tubes - Details

4.

PROBE DETERIORATION DETERMINATION METHOD, PROBE DETERIORATION DETERMINATION DEVICE, AND PROBE DETERIORATION DETERMINATION PROGRAM

      
Application Number JP2023037632
Publication Number 2024/150494
Status In Force
Filing Date 2023-10-18
Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kuroda, Kotomi
  • Hirade, Masato

Abstract

In the present invention, a computer performs: a step (S20) for acquiring a sample image which is generated on the basis of the measurement of a scanning probe microscope; a step (S30) for acquiring, by inputting the sample image to a discriminator, deterioration information indicating whether or not a probe of the scanning probe microscope has deteriorated; and a step (S50) for outputting the deterioration information. The discriminator has undergone a learning process by using teacher data so as to output, when receiving input of the image generated on the basis of the measurement of the scanning probe microscope, the deterioration information indicating whether or not the probe of the scanning probe microscope has deteriorated.

IPC Classes  ?

  • G01Q 70/10 - Shape or taper
  • G01Q 60/38 - Probes, their manufacture or their related instrumentation, e.g. holders

5.

Respiratory Measurement Method, Respiratory Measurement Device, and Respiratory Measurement System

      
Application Number 18560205
Status Pending
Filing Date 2022-02-01
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Imai, Shinji
  • Murata, Koichi
  • Furuta, Masafumi

Abstract

A respiratory measurement method includes acquiring respiration signals by a detector attached to a human body, extracting, from the acquired respiration signals, a first signal indicating an inspiratory phase and a second signal indicating an expiratory phase, and calculating information corresponding to an amount of ventilation by respiration on the basis of the extracted first signal and second signal. The calculating includes performing, for each of the respiration signals, different operation depending upon whether the signal is the first signal or the second signal.

IPC Classes  ?

  • A61B 5/087 - Measuring breath flow
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity

6.

Sleeping Video Analysis Method And Sleeping Video Analysis Apparatus

      
Application Number 18559084
Status Pending
Filing Date 2022-03-04
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Akazawa, Ayako
  • Nagashima, Tomotaka
  • Sotoguchi, Akie

Abstract

A sleeping video analysis method according to this invention includes a lying posture estimation step (step 311) of estimating a lying posture of a subject (200) while sleeping based on a sleeping video of a subject (200) while sleeping; a lying posture classification step (step 313) of classifying the lying posture based on a lying posture estimation result(s) of the lying posture estimation step (step 311); and a body movement measurement step (step 314) of measuring body movement based on the lying posture estimation result(s) of the lying posture estimation step (311). The sleeping video analysis method includes a display step of displaying at least one of a lying posture classification result(s) and a body movement measurement result(s).

IPC Classes  ?

  • G06V 20/40 - Scenes; Scene-specific elements in video content
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • G06V 10/24 - Aligning, centring, orientation detection or correction of the image
  • G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
  • G06V 40/20 - Movements or behaviour, e.g. gesture recognition

7.

OPTICAL MEASUREMENT DEVICE AND LIQUID CHROMATOGRAPH SYSTEM

      
Application Number 18402348
Status Pending
Filing Date 2024-01-02
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Yonekura, Takuya

Abstract

An optical part (2) including a measurement cell (12), a light source part (10) that emits light to be emitted to the measurement cell (12), a light receiving element (14), and a shutter (18) that shields light to the light receiving element (14), a storage part (6), a controller (4), and a calculator (8). The optical part (2) includes a temperature control element (26) for adjusting a temperature of the optical part (2), the controller (4) is configured to control the temperature control element (26) so that a temperature of the optical part (2) becomes a target temperature which is set in advance, and to execute, at least in a case where a measured value of the dark current at the target temperature is not stored in the storage part (6), measurement of the dark current immediately after a transition from an unstable state to a stable state, the storage part (6) stores a measured value of the dark current acquired in the measurement, and the calculator is configured to continuously use a same measured value of the dark current in the calculation processing while the stable state of the temperature of the optical part continues.

IPC Classes  ?

8.

DETECTION DEVICE AND DETECTION METHOD

      
Application Number 18401532
Status Pending
Filing Date 2023-12-31
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka, Hiroto

Abstract

A detection device includes a CPU and a memory. CPU sets a boundary point at which a melting curve is divided into a front region and a rear region, sets a start point and an end point, calculates an approximate straight line by a least squares method, and repeats setting processing of the approximate straight line. CPU sets a first straight line in the front region, sets a second straight line in the rear region, and detects, as a melting temperature, a temperature of a nucleic acid corresponding to an intersection between a melting curve and a line connecting intermediate values of absorbance of the nucleic acid at which a temperature of the nucleic acid is the same on the first straight line and the second straight line.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

9.

Antibody Production Assisting Method and Antibody Production Assisting Program

      
Application Number 18560148
Status Pending
Filing Date 2022-03-18
First Publication Date 2024-07-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Motoyama, Kento
  • Yamada, Kaori
  • Kanai, Masaki
  • Suzuki, Takashi

Abstract

An antibody production assisting method for assisting production of an antibody includes: acquiring time-series data that indicates, in in chronological order, a plurality of metabolite data and a culture parameter, the plurality of metabolite data each corresponding to a respective amount of a plurality of metabolites generated by culturing a cell line for producing the antibody, the culture parameter being detected from the cell line in culture; acquiring a degree of relevance between the culture parameter and each of the plurality of metabolites on the basis of the time-series data; and generating display data based on the degree of relevance.

IPC Classes  ?

  • G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

10.

Biological Information Measurement System

      
Application Number 18028949
Status Pending
Filing Date 2021-09-09
First Publication Date 2024-07-18
Owner Shimadzu Corporation (Japan)
Inventor
  • Furuta, Masafumi
  • Inoue, Yoshihiro
  • Nakamura, Shin

Abstract

A physiological information measurement system capable of achieving decrease in time for attachment of a plurality of sensors to a subject and preparation for measurement is provided. A head-mounted measurement system includes a housing attachable to and removable from a head of a subject, a plurality of sensors held by the housing, and a control unit (signal processing unit) that synchronizes signals outputted from the plurality of sensors with each other. The plurality of sensors include an NIRS probe (a first sensor) that measures brain activities and an ultra-wide-angle camera (a second sensor) that obtains an image of a face of the subject.

IPC Classes  ?

  • A61B 5/18 - Devices for psychotechnics; Testing reaction times for vehicle drivers
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/01 - Measuring temperature of body parts
  • A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/026 - Measuring blood flow
  • A61B 5/08 - Measuring devices for evaluating the respiratory organs
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/16 - Devices for psychotechnics; Testing reaction times
  • A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
  • A61B 5/256 - Wearable electrodes, e.g. having straps or bands
  • A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]

11.

X-RAY IMAGING APPARATUS

      
Application Number 18531111
Status Pending
Filing Date 2023-12-06
First Publication Date 2024-07-18
Owner Shimadzu Corporation (Japan)
Inventor
  • Onodera, Hiroki
  • Yoshida, Koki
  • Hirose, Dai

Abstract

An Xray imaging apparatus is provided with an X-ray source, an X-ray detector, an arm, an arm driving mechanism, an X-ray detector moving mechanism, a model acquisition unit for acquiring a subject model of a surface shape of the subject, and a controller configured to select a target position where a distance of the X-ray detector to a surface of the subject model is shorter, out of a first target position set based on a position of the subject model and a preset second target position and perform a control to move the X-ray detector toward the selected target position.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B 6/10 - Application or adaptation of safety means
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

12.

DEFECT INSPECTION APPARATUS AND DEFECT INSPECTION METHOD

      
Application Number 18290270
Status Pending
Filing Date 2022-03-25
First Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Horikawa, Hiroshi
  • Takubo, Kenji
  • Hatahori, Takahide

Abstract

A defect inspection apparatus (100) according to the present invention includes an exciter (1), an irradiator (laser illuminator 2) configured to irradiate an inspection target (8) with laser light, and a measurer (3) configured to change a phase of the laser light reflected by the inspection target (8) to cause the laser light having an unchanged phase to interfere with the laser light having a changed phase, and to measure the interference light. The measurer (3) is configured to acquire an interference image (71) representing a vibration state of the inspection target (8) as viewed in a direction extending along a first light path (21), and an interference image (72) representing a vibration state of the inspection target (8) as viewed in a direction extending along a second light path (22) in which the reflected laser light travels from the inspection target (8) in a direction different from the first light path (21).

IPC Classes  ?

  • G01N 29/24 - Probes
  • G01N 29/04 - Analysing solids
  • G01N 29/32 - Arrangements for suppressing undesired influences, e.g. temperature or pressure variations

13.

METHOD FOR ANALYZING NEUROGRANIN-RELATED PEPTIDE

      
Application Number 18559077
Status Pending
Filing Date 2022-03-25
First Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Kaneko, Naoki

Abstract

A method for analyzing a neurogranin-related peptide contained in a biological sample includes, in the stated order: a binding step of bringing the biological sample into contact with a carrier in a binding solution to obtain a bound body in which the neurogranin-related peptide is bound to the carrier; a washing step of washing the bound body using a washing solution; an elution step of bringing the bound body into contact with an acidic solution to obtain an eluate in which the neurogranin-related peptide is eluted in the acidic solution; and a detection step of detecting the neurogranin-related peptide in the eluate by mass spectrometry. Both the binding solution and the washing solution contain a surfactant, and the number of carbon atoms of a hydrophobic group of each surfactant is 9 or more and 11 or less.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

14.

ANALYSIS SYSTEM

      
Application Number JP2023038114
Publication Number 2024/147221
Status In Force
Filing Date 2023-10-23
Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Midorikawa, Yusuke

Abstract

An analysis system (100) comprises a storage device (30) and a control device (10), wherein: the storage device (30) comprises a rotating body (40) having a placement surface, a conveying body (50), and a door covering a first opening (35) for placing a sample container on the placement surface from outside the storage device (30); the control device (10) executes conveying processing to cause the sample container to be conveyed by the conveying body (50); the control device (10) determines whether an amount of deviation of a rotation angle of the rotating body (40) before and after the door has been opened and closed exceeds a first threshold; if the amount of deviation of the rotation angle exceeds the first threshold, the control device (10) returns the rotating body (40) to a reference angle position and then executes the conveying processing; and if the amount of deviation of the rotation angle does not exceed the first threshold, the control device (10) executes the conveying processing without returning the rotating body to the reference angle position.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

15.

X-RAY IMAGING SYSTEM AND X-RAY IMAGING METHOD

      
Application Number JP2023045861
Publication Number 2024/147291
Status In Force
Filing Date 2023-12-21
Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Okumura, Hiroshi
  • Yamamoto, Junya
  • Takeda, Ryo

Abstract

An X-ray imaging system (100) includes: an X-ray imaging apparatus (1) having an X-ray irradiation unit (10) and an X-ray detector (11); and a portable terminal (2) disposed near the X-ray detector. The portable terminal includes: a feature-point detection unit (20) that optically detects a feature point in the X-ray irradiation unit; a controller (21) that acquires at least one of information about the relative positions of the X-ray irradiation unit and the X-ray detector and information about the relative angles of the X-ray irradiation unit and the X-ray detector on the basis of the feature point; and a display (22) that displays the information acquired by the controller.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

16.

MATERIAL TESTING MACHINE

      
Application Number JP2023045957
Publication Number 2024/147297
Status In Force
Filing Date 2023-12-21
Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Murakami Takashi
  • Awazu Takayuki

Abstract

The present invention prevents deformation in an out-of-plane direction and lowers sliding friction when applying a compressive load. Provided is a material testing machine in which a pair of grasping members grasp two surfaces of a test piece and a compressive load is applied to the test piece to perform a material test, wherein a rotating body is provided to respective surfaces of the grasping members on sides that contact the test piece.

IPC Classes  ?

  • G01N 3/04 - Chucks
  • G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces

17.

X-Ray Imaging Apparatus and Subject Holding Mechanism

      
Application Number 18497127
Status Pending
Filing Date 2023-10-30
First Publication Date 2024-07-11
Owner Shimadzu Corporation (Japan)
Inventor Hayakawa, Masashi

Abstract

An X-ray imaging apparatus according to this invention includes an X-ray irradiator, an X-ray detector and a subject holding mechanism; the subject holding mechanism includes a subject grasping mechanism including a pair of graspers and a holder, and a rotation mechanism configured to rotate the subject grasping mechanism; the holder includes a first fixed position adjuster and a second fixed position adjuster; and one of the pair of graspers is fixed to the holder at a position that is adjusted by the first fixed position adjuster, and the another of the pair of graspers is fixed to the holder at a position that is adjusted by the second fixed position adjuster.

IPC Classes  ?

  • G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]

18.

Photoreaction Evaluation Apparatus

      
Application Number 18558169
Status Pending
Filing Date 2022-03-07
First Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Tamaki, Takahiro

Abstract

A measurement light source is arranged on a rear surface side of a surface at a sample position irradiated with light by an irradiation light source and a detector is arranged on a front surface side of the surface at the sample position irradiated with light by the irradiation light source. A radiation intensity calculator calculates a radiation intensity at each wavelength of irradiation light from the irradiation light source based on a first detected intensity distribution, a second detected intensity distribution, and radiation characteristics of a standard light source. An irradiated photon number calculator calculates the number of irradiated photons at each wavelength of irradiation light from the irradiation light source based on the radiation intensity at each wavelength.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01J 3/42 - Absorption spectrometry; Double-beam spectrometry; Flicker spectrometry; Reflection spectrometry
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands

19.

IMAGE PROCESSING METHOD AND IMAGE PROCESSING APPARATUS

      
Application Number 18558605
Status Pending
Filing Date 2022-05-20
First Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Sawada, Ryuji

Abstract

An image processing method according to this invention includes a step of converting pixel values of pixels in a cell image (31) into relative values; a step of acquiring a frequency-component extraction image (50) that extracts a predetermined frequency component from the converted cell image (40); a step to acquiring a first image (61a) by binarizing the converted cell image (40), and a second image (62) by binarizing the frequency-component extraction image (50); and a step of generating a binary image (70) of the cell image (31) by combining the first image (61) and the second image (62).

IPC Classes  ?

  • G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction
  • G06T 5/20 - Image enhancement or restoration by the use of local operators
  • G06T 5/70 - Denoising; Smoothing
  • G06V 10/60 - Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model
  • G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

20.

ANALYSIS RESULT DISPLAY PROCESSING APPARATUS, ANALYSIS RESULT DISPLAY PROCESSING METHOD, AND ANALYSIS RESULT DISPLAY PROCESSING PROGRAM

      
Application Number JP2023000135
Publication Number 2024/147191
Status In Force
Filing Date 2023-01-06
Publication Date 2024-07-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kawamitsu Haruna
  • Kawamura Kazuhiro

Abstract

This analysis result display processing apparatus comprises: a storage device for storing a result of analysis, the analysis being conducted using a chromatogram and a first number of analysis methods, wherein the chromatogram is obtained by executing analysis on a sample using an apparatus in which chromatograph and a mass spectroscope are combined, the first number of analysis methods are methods for confirming the presence or absence of a first number of compounds in the sample, and the result of analysis relates to presence or absence of the first number of compounds in the sample; a reception processing unit for receiving a designation of a second number of compounds selected from the first number of compounds, wherein the second number is smaller than the first number; and a display processing unit for performing processing so that a result of analysis relating to the presence or absence of the second number of compounds and extracted from the result of analysis relating to the presence or absence of the first number of compounds stored in the storage device is displayed on a display device.

IPC Classes  ?

  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

21.

ANALYSIS DEVICE AND WAVEFORM PROCESSING PROGRAM FOR ANALYSIS DEVICE

      
Application Number 18288350
Status Pending
Filing Date 2021-04-30
First Publication Date 2024-07-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Yasuda, Hiroyuki

Abstract

An analysis device includes: a waveform deformation unit to enlarge or reduce a target signal waveform and indicating a change in signal intensity depending on a change in a value of a predetermined parameter by a scale factor of N in the direction of the signal intensity axis and/or enlarge or reduce by a scale factor of M in the direction of the predetermined parameter axis; a peak detection unit to use a learned model generated by machine learning and use, as an input, a signal waveform after deformation, and output, as a detection result, the start point and the end point of the peak; and a waveform inverse deformation unit to reduce or enlarge information on a start point and an end point of a peak by a scale factor inverse to that at the time of deformation, and obtain a peak detection result.

IPC Classes  ?

22.

MEASUREMENT DATA ANALYSIS DEVICE, MEASUREMENT DATA ANALYSIS METHOD AND NON-TRANSITORY COMPUTER READABLE MEDIUM STORING MEASUREMENT DATA ANALYSIS PROGRAM

      
Application Number 18396521
Status Pending
Filing Date 2023-12-26
First Publication Date 2024-07-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Tamai, Yusuke
  • Noda, Akira

Abstract

A measurement data analysis device analyzes measurement data of a sample obtained in an analyzer, and includes a noise variation estimator that estimates a noise variation coefficient, the noise variation coefficient being applied to a noise included in the measurement data by a frequency filter included in the analyzer, an acquirer that acquires the measurement data to which the frequency filter has been applied in the analyzer, and a calculator that estimates, with use of the noise variation coefficient, a noise intensity included in the measurement data obtained before the frequency filter is applied, and analyzes, based on the estimated noise intensity, the measurement data.

IPC Classes  ?

  • G01D 3/032 - Measuring arrangements with provision for the special purposes referred to in the subgroups of this group mitigating undesired influences, e.g. temperature, pressure gating undesired signals

23.

X-RAY IMAGE IMAGING METHOD, X-RAY IMAGE IMAGING SYSTEM, AND X-RAY IMAGE IMAGING PROGRAM

      
Application Number JP2023033729
Publication Number 2024/142509
Status In Force
Filing Date 2023-09-15
Publication Date 2024-07-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Yamamoto, Junya
  • Okumura, Hiroshi
  • Takeda, Ryo

Abstract

This X-ray image imaging method comprises: a step for acquiring, on a portable terminal, a preliminary imaging X-ray image Gx1 that has been imaged using X-rays that have been emitted from an X-ray emission unit 11 and have passed through an examination object Pa; a step for acquiring imaging assistance information J on the portable terminal on the basis of the preliminary imaging X-ray image Gx1, said imaging assistance information J assisting with imaging of a main imaging X-ray image G2 that is imaged using X-rays emitted from the X-ray emission unit 11 after the imaging of the preliminary imaging X-ray image Gx1; and a step for displaying the imaging assistance information J on a display unit 44 of the portable terminal 4 prior to the imaging of the main imaging X-ray image Gx2.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

24.

ELECTROCARDIOGRAPH AND ELECTROCARDIOGRAPHIC MEASUREMENT METHOD

      
Application Number JP2023041327
Publication Number 2024/142655
Status In Force
Filing Date 2023-11-16
Publication Date 2024-07-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Murata, Koichi
  • Furuta, Masafumi

Abstract

The purpose of the present invention is to enable accurate diagnosis even when the attitude of wearing of an electrocardiograph is incorrect. For achieving the purpose, the electrocardiograph is provided with: a first electrode 12a and a second electrode 12b; a holder 11 that holds each of the electrodes 12a, 12b and is attached to the body of a subject M of measurement so as to allow the electrodes 12a, 12b to come into contact with the body of the subject M; an attitude detection sensor 13 that detects the attitude of the holder 11; an electrocardiographic signal detection unit 31 that detects an electrocardiographic signal from a potential difference between the electrodes 12a, 12b; and an electrocardiographic signal correction unit 33 that corrects the electrocardiographic signal detected by the electrocardiographic signal detection unit 31 on the basis of a detection value obtained by the attitude detection sensor 13.

IPC Classes  ?

  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • A61B 5/276 - Protection against electrode failure

25.

GAS ANALYZER

      
Application Number 18288086
Status Pending
Filing Date 2022-01-28
First Publication Date 2024-06-27
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Senda, Atsuko
  • Itabashi, Toshihisa

Abstract

A gas analyzer includes a gas flow path through which an analysis target gas flows, and a drain pot upstream of an analysis unit to analyze the gas, the drain pot into which liquid generated by cooling the gas is introduced, wherein the drain pot includes: a first liquid container to receive a terminal end of a first drain flow path from which the liquid is discharged and has a communication port above the terminal end of the first drain flow path; a second drain flow path to extend outward and downward from the communication port of the first liquid container; and a second liquid container to receive a terminal end of the second drain flow path and has a discharge port above the terminal end of the first drain flow path and the terminal end of the second drain flow path, and below the communication port.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

26.

MATERIAL TESTING MACHINE AND FIXING MECHANISM

      
Application Number 18390580
Status Pending
Filing Date 2023-12-20
First Publication Date 2024-06-27
Owner SHIMADZU CORPORATION (Japan)
Inventor Karita, Maiko

Abstract

A tensile testing machine includes a voice operation device, in which the voice operation device is attached to a machine column via a fixing mechanism, and the fixing mechanism includes: three or more elastic bodies attached to either one side of the machine column and the voice operation device and disposed in contact with another side; and a magnet body attached to the other side and disposed in non-contact with the one side to suck and fix the one side.

IPC Classes  ?

  • G01N 3/02 - Investigating strength properties of solid materials by application of mechanical stress - Details
  • G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces

27.

X-RAY GENERATING DEVICE AND X-RAYS IMAGING APPARATUS

      
Application Number 18497097
Status Pending
Filing Date 2023-10-30
First Publication Date 2024-06-27
Owner Shimadzu Corporation (Japan)
Inventor
  • Keyaki, Yasuyuki
  • Harada, Daisuke
  • Masaki, Toshimichi
  • Yamada, Katsuo

Abstract

An X-ray generating device includes an electron beam generator configured to generate an electron beam; a target configured to generate X-rays in response to the electron beam incident on the target; an eccentric rotator configured to be cocentrically rotated to rotate the target while changing a position of the target; and a driver configured to rotationally drive the eccentric rotator.

IPC Classes  ?

  • H01J 35/10 - Rotary anodes; Arrangements for rotating anodes; Cooling rotary anodes
  • G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays

28.

ION SOURCE APPARATUS AND MASS SPECTROMETER

      
Application Number 18508669
Status Pending
Filing Date 2023-11-14
First Publication Date 2024-06-27
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Zhang, Xiaoqiang
  • Geng, Zhi
  • Sun, Wenjian

Abstract

The technical solution of the present disclosure provides an ion source apparatus and a mass spectrometer. According to the ion source apparatus, the axial ion guide assembly includes the plurality of multipole segments extending axially, the transmission path of axial ions is straight, and the ion transmission efficiency is substantially unaffected when the axial ion source is used alone. Further, since the ion outlet of the lateral ion guide assembly faces a gap between two adjacent segmented multipoles, the lateral ion guide assembly does not affect axial field, thereby integrating the multiple ion sources while ensuring the ion transmission efficiency and ion constraining of the axial ion source.

IPC Classes  ?

  • H01J 49/06 - Electron- or ion-optical arrangements
  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

29.

ION GENERATOR, MASS SPECTROMETER AND METHOD OF GENERATING IONS

      
Application Number 18541196
Status Pending
Filing Date 2023-12-15
First Publication Date 2024-06-27
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sun, Wenjian
  • Geng, Zhi

Abstract

The technical solution of the present disclosure provides an ion generator for dissociating sample ions for the second time by laser, of which the dissociation efficiency is further improved with a lower cost. The ion generator includes: a desorption device configured to desorb sample particles into a pre-determined area; a light source emitting a light beam and focusing the light beam to the pre-determined area, thereby ionizing, fragmenting or atomizing the sample particles in the pre-determined area; and a focusing reflector for reflecting the light beam that is emitted by the light source and travels through the pre-determined area, and focusing the light beam to the pre-determined area, thereby ionizing, fragmenting or atomizing the sample particles in the pre-determined area at least once again, during which each time the light beam is reflected on the surface of the focusing reflector, the light beam is focused to the pre-determined area correspondingly.

IPC Classes  ?

  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

30.

X-RAY FLUOROSCOPIC IMAGING DEVICE

      
Application Number JP2023037236
Publication Number 2024/135063
Status In Force
Filing Date 2023-10-13
Publication Date 2024-06-27
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka, Masahiro

Abstract

This X-ray fluoroscopic imaging device (100) is provided with a top board (2), a top board operation unit (51) and a control unit (31), in which the control unit is configured such that the top board is moved in accordance with an operation input to the top board operation unit in a first control when the movement of the top board is not inhibited, and is also configured such that a center (42a) of an irradiation field (42) of X ray in an X-ray image (41) in a display unit (40) is moved while preventing the movement of the top board in accordance with an operation input to the top board operation unit in a second control when the movement of the top board is inhibited.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B 6/04 - Positioning of patients; Tiltable beds or the like
  • A61B 6/40 - Arrangements for generating radiation specially adapted for radiation diagnosis
  • A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis

31.

Near-infrared imaging device

      
Application Number 29842969
Grant Number D1032845
Status In Force
Filing Date 2022-06-17
First Publication Date 2024-06-25
Grant Date 2024-06-25
Owner SHIMADZU CORPORATION (Japan)
Inventor Kang, Hyeri

32.

PHOTOTHERAPY PLANNING DEVICE AND PHOTOTHERAPY PLANNING METHOD

      
Application Number 18286358
Status Pending
Filing Date 2021-08-17
First Publication Date 2024-06-20
Owner Shimadzu Corporation (Japan)
Inventor Ishikawa, Akihiro

Abstract

This phototherapy planning device is provided with a three-dimensional image acquisition unit configured to acquire a three-dimensional surface image showing an affected part of a subject, a rod-shaped member position adjustment unit configured to adjust a position of the rod-shaped member when inserting the rod-shaped member into the affected part on an image space, a light propagation region acquisition unit configured to acquire the light propagation region in which light propagates from the rod-shaped member, a cross-sectional image generation unit configured to generate a cross-sectional image that displays an internal morphological image including the affected part of the subject, the rod-shaped member, and the light propagation region, and a display control unit configured to perform control for displaying the cross-sectional image.

IPC Classes  ?

  • A61N 5/06 - Radiation therapy using light
  • A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor

33.

MONITORING SYSTEM AND MONITORING METHOD

      
Application Number 18287789
Status Pending
Filing Date 2022-03-28
First Publication Date 2024-06-20
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sasaki, Andy
  • Lee, Timothy

Abstract

A monitoring system that monitors a reactor for producing a reaction product includes a first controller that controls the reactor, an analyzer that analyzes the reaction product, a second controller that controls the analyzer, and an information transmission device that transmits information between the first controller and the second controller, wherein the information transmission device includes an information receiver that receives information from one controller of the first and second controllers, a converter that converts information received from the information receiver into a format processable by another controller of the first and second controllers, and an information sender that sends information converted by the converter to the other controller.

IPC Classes  ?

  • G05B 19/4155 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus

34.

GAS CHROMATOGRAPH

      
Application Number 18287285
Status Pending
Filing Date 2021-04-19
First Publication Date 2024-06-20
Owner Shimadzu Corporation (Japan)
Inventor Nakama, Yuji

Abstract

A gas chromatograph includes: a gas chromatograph body having an interior space thermally isolated from an outside; at least one sample vaporization unit mounted on an upper portion of the gas chromatograph body, the sample vaporization unit having a housing provided therein with a heating space surrounded by a heater and being configured to vaporize a sample injected into the heating space by heat from the heater and introduce the vaporized sample into the gas chromatograph body; and at least one cooling fan mounted on the gas chromatograph body to correspond to the at least one sample vaporization unit to blow cooling air toward the least one sample vaporization unit. A heat insulating member is interposed between the gas chromatograph body and the at least one cooling fan to thermally isolate the at least one cooling fan from the gas chromatograph body.

IPC Classes  ?

35.

METHOD AND SYSTEM FOR COMPOUND DETERMINATION BY MASS SPECTROMETRY

      
Application Number 18518273
Status Pending
Filing Date 2023-11-22
First Publication Date 2024-06-20
Owner SHIMADZU CORPORATION (Japan)
Inventor Ito, Yuki

Abstract

Mass spectrometry data is acquired by performing a scan measurement over a predetermined m/z range on a sample by a mass spectrometer (11). Based on the data, whether or not predetermined compounds are contained in the sample is determined (14). A dataset is created in which the mass spectrometry data, and information identifying already-determined compounds are related to an ID of the sample (16). The datasets created for a plurality of samples are accumulated to construct a database. From this database, a dataset related to a re-determination target sample included in the plurality of samples is read. For each of re-determination target compounds including a compound which is none of the already-determined compounds, whether or not the compound concerned was contained in the re-determination target sample is determined based on the mass spectrometry data included in the dataset.

IPC Classes  ?

  • G01N 30/72 - Mass spectrometers
  • G01N 30/86 - Signal analysis
  • G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

36.

DISPLAY METHOD IN X-RAY IMAGING DEVICE AND X-RAY IMAGING DEVICE

      
Application Number JP2023032917
Publication Number 2024/127751
Status In Force
Filing Date 2023-09-08
Publication Date 2024-06-20
Owner SHIMADZU CORPORATION (Japan)
Inventor Shirota, Ken

Abstract

This display method in an X-ray imaging device (100) comprises: a step for executing simultaneously and individually, in one control device (40), an X-ray image generation software (61) which is a product of a first manufacturing source and an imaging condition setting software (62) which is a product of a second manufacturing source, thereby forming an X-ray image display screen (71) and an imaging condition setting screen (72); and a step for displaying the X-ray image display screen and the imaging condition setting screen side by side in different regions of a display unit (70).

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

37.

ORGAN PERFUSION DEVICE

      
Application Number JP2023040846
Publication Number 2024/127882
Status In Force
Filing Date 2023-11-14
Publication Date 2024-06-20
Owner
  • SHIMADZU CORPORATION (Japan)
  • KYOTO UNIVERSITY (Japan)
Inventor
  • Kunimitsu, Takeru
  • Kashihara, Minoru
  • Hata, Koichiro
  • Tajima, Tetsuya

Abstract

An organ perfusion device (1) includes: a chamber (100) that is open to the atmosphere and houses an organ; an inflow channel (220) that receives a perfusion fluid to be sent to the organ; and an outflow channel (210) that can be connected at one end to an inlet blood vessel of the organ to send the perfusion fluid received by the inflow channel toward the inlet blood vessel. The chamber (100) includes a connecting port (120) that is openable/closable and configured to be connectable to the inlet flow channel (220). In the organ perfusion device (1), an open system circuit is formed by connecting an end (401) that receives the perfusion fluid in the inflow channel (220) to the connecting port (120), and a closed system circuit is formed by closing the connecting port and connecting an end (402) that receives the perfusion fluid in the inflow channel to an outlet blood vessel of the organ.

IPC Classes  ?

38.

RIBOSOMAL PROTEIN JUDGEMENT METHOD, BIOLOGICAL SPECIES IDENTIFICATION METHOD, AND MASS SPECTROMETRY APPARATUS

      
Application Number 18078171
Status Pending
Filing Date 2022-12-09
First Publication Date 2024-06-13
Owner SHIMADZU CORPORATION (Japan)
Inventor Teramoto, Kanae

Abstract

Provided is a ribosomal protein judgement method, comprising: an attribution step that involves comparing observed m/z values indicated by peaks on a mass spectrum detected by mass spectrometry of a sample containing ribosomal proteins, with first calculated m/z values based on a database, and attributing at least some of the peaks thus detected to ribosomal proteins; and a presumption step that involves presuming a protein corresponding to a peak with a relative intensity from 50 to 150% relative to an approximate curve or an approximate straight line plotted with relative intensities of the peaks attributed to ribosomal proteins, to be a ribosomal protein.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

39.

SAMPLE ANALYSIS DEVICE, SAMPLE ANALYSIS METHOD, PHARMACEUTICAL ANALYSIS DEVICE AND PHARMACEUTICAL ANALYSIS METHOD

      
Application Number 18517981
Status Pending
Filing Date 2023-11-22
First Publication Date 2024-06-13
Owner SHIMADZU CORPORATION (Japan)
Inventor Nakai, Yusuke

Abstract

A sample analysis device includes a quantitative information calculator that calculates, based on a plurality of measurement data pieces, a plurality of quantitative measurement information pieces of a substance included in a sample, and an estimator that provides the plurality of quantitative measurement information pieces calculated by the quantitative information calculator to a reaction model to estimate a parameter of the reaction model. In the reaction model, an integrated error term for integration of errors based on setting values of the temperature and the humidity set under the plurality of analysis conditions is included in the reaction model.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

40.

GAS ANALYSIS DEVICE

      
Application Number 18279295
Status Pending
Filing Date 2021-10-21
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Senda, Atsuko
  • Itabashi, Toshihisa

Abstract

Provided is a gas analyzer capable of facilitating the treatment of water generated from an analysis target gas and collected in a drain pot. A gas analyzer 10 includes: an analysis target gas flow path 13 through which an analysis target gas flows; a cooling unit 14 which is provided in the analysis target gas flow path 13 and configured to cool the analysis target gas; a drain flow path 141 through which liquid generated in the cooling unit 14 is discharged; a closed container 20 connected to the drain flow path 141; a selective permeation member 211 which is a member partitioning the inside of the closed container 20 into the drain introduction space 200 connected to the drain flow path 141 and a gas introduction space 210 and configured to selectively let gas-phase water permeate from the drain introduction space 200 to the gas introduction space 210; a gas source 22 configured to introduce a gas into the gas introduction space 210; and a gas discharge port 26 through which a gas in the gas introduction space 210 is discharged

IPC Classes  ?

  • G01N 1/22 - Devices for withdrawing samples in the gaseous state
  • G01N 1/24 - Suction devices
  • G01N 1/40 - Concentrating samples
  • G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

41.

DUAL PHASE DIFFERENCE PUMP

      
Application Number 18509626
Status Pending
Filing Date 2023-11-15
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor Kokabu, Takuya

Abstract

A dual phase difference pump 100 that can reduce the pulsation of a discharge pressure as much as possible. The dual phase difference pump 100 includes, in series, two gear pump units 1, 2 each including a pair of gears 4, 5 configured to mesh with each other. Shafts 42 of the gear pump units 1, 2 are coupled to each other by using a coupler 6. The pair of gears 4, 5 mesh with each other without backlash. The coupler 6 is configured to couple the shafts 42 to each other at any one of a plurality of predetermined phase angles, and is configured to make a phase difference between the gear pump units 1, 2 equal irrespective of which predetermined phase angle is selected among the plurality of predetermined phase angles as a phase angle at which the shafts 42 are coupled to each other.

IPC Classes  ?

  • F16D 1/116 - Quick-acting couplings in which the parts are connected by simply bringing them together axially having retaining means rotating with the coupling and acting by interengaging parts, i.e. positive coupling the interengaging parts including a continuous or interrupted circumferential groove in the surface of one of the coupling parts
  • F04C 2/08 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing

42.

OLIGONUCLEOTIDE DISPLAY PROCESSING DEVICE

      
Application Number JP2022044485
Publication Number 2024/116397
Status In Force
Filing Date 2022-12-01
Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Uchiyama, Kosuke
  • Hirama, Tomohiro
  • Kato, Noriko

Abstract

An oligonucleotide display processing device according to the present invention comprises: an input reception unit (34) that receives input of base information, sugar information, and phosphate group information of each of a plurality of nucleotides forming a target oligonucleotide, and arrangement information of the plurality of nucleotides; a storage unit (35) having pre-stored therein labels which each include at least one of a character or a symbol, and which are base labels corresponding to the base information, sugar labels corresponding to the sugar information, and phosphate group labels corresponding to the phosphate group information; an extraction unit (45) that extracts, from the storage unit, base labels, sugar labels, and phosphate group labels respectively corresponding to the base information, the sugar information, and the phosphate group information received by the input reception unit; and an output unit (46) that arranges, on the basis of the arrangement information of each of the nucleotides, the base labels, the sugar labels, and the phosphate group labels of the plurality of nucleotides extracted by the extraction unit, and disposes and displays, on a display unit (24), the base labels, the sugar labels, and the phosphate group labels of the respective nucleotides such that base labels of adjacent nucleotides are arranged side by side. The present invention enables easy understanding of the structure of oligonucleotides.

IPC Classes  ?

  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

43.

METHOD FOR QUANTIFYING ANALYTE CONTAINING MYCOPHENOLIC ACID AND ONE OR MORE OTHER IMMUNOSUPPRESSANTS IN TARGET BLOOD SAMPLE

      
Application Number JP2023042587
Publication Number 2024/117136
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner
  • JICHI MEDICAL UNIVERSITY (Japan)
  • SHIMADZU CORPORATION (Japan)
Inventor
  • Aizawa Kenichi
  • Iwami Daiki
  • Sakuma Yasunaru

Abstract

The present invention provides a means for quantifying and analyzing an analyte containing a mycophenolic acid and one or more other immunosuppressants by using the whole blood fraction without separating a blood sample. One aspect of the present invention pertains to a method for quantifying an analyte containing a mycophenolic acid and one or more other immunosuppressants in a target blood sample, the method comprising: an analyte concentration measurement step for measuring the concentration of an analyte containing a mycophenolic acid and one or more other immunosuppressants in the whole blood fraction of the blood sample; a hematocrit value acquisition step for acquiring a hematocrit value of the target blood sample; and a mycophenolic acid concentration conversion step for converting the concentration of the mycophenolic acid in the whole blood fraction of the blood sample to the concentration of the mycophenolic acid in a plasma fraction of the blood sample on the basis of the hematocrit value.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • A61K 31/365 - Lactones
  • A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

44.

Mass Spectrometer

      
Application Number 18285119
Status Pending
Filing Date 2021-05-14
First Publication Date 2024-06-06
Owner Shimadzu Corporation (Japan)
Inventor Ueno, Yoshihiro

Abstract

One mode of the mass spectrometer according to the present invention is a mass spectrometer including an ion source configured to ionize a component contained in a sample gas, the ion source (3) including: an ionization chamber (30) having an ion ejection opening (301) and forming a space substantially partitioned from an outside inside the ionization chamber; a thermal electron supply unit (32) configured to supply thermal electrons to an inside of the ionization chamber; a magnetic field forming unit (34, 35) configured to form a magnetic field inside the ionization chamber such that the thermal electrons move helically; and a deflection electric field forming unit (37, 7) configured to form a deflection electric field deflecting ions derived from the component generated in the ionization chamber by a direct or indirect action of the thermal electrons in a direction against a force received from the magnetic field when the ions are moving toward the ion ejection opening.

IPC Classes  ?

  • H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
  • H01J 49/06 - Electron- or ion-optical arrangements
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

45.

X-RAY IMAGING APPARATUS, IMAGE PROCESSING APPARATUS, AND IMAGE PROCESSING PROGRAM

      
Application Number 18285144
Status Pending
Filing Date 2021-12-27
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Hu, Erzhong
  • Hosomi, Naomasa

Abstract

An X-ray imaging apparatus is provided with an X-ray irradiation unit, an X-ray detection unit, an X-ray image generation unit, a display unit, and a control unit. The control unit includes an enhanced image generation unit that generates, as an enhanced image, at least one of an output image of a trained model and a composite image generated based on the output image and the X-ray image, based on the trained model, and an image output unit configured to make the display unit display the X-ray image and at least one of the output image and the composite image simultaneously or switchably.

IPC Classes  ?

  • A61B 6/12 - Devices for detecting or locating foreign bodies
  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

46.

MEDICAL IMAGING APPARATUS

      
Application Number JP2023033018
Publication Number 2024/116540
Status In Force
Filing Date 2023-09-11
Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka Masahiro

Abstract

Provided is a medical imaging apparatus with which it is possible to flexibly execute appropriate assistance for an operator performing complex imaging. An X-ray imaging apparatus 10 according to the present invention comprises: a console 11 which allows an operator to input a description; an information processing unit 13 which associates an imaging type with the content of the description provided by the operator; a memory 21 which stores the content of the description by the operator in association with the imaging type; an imaging type acquisition unit 14 which acquires a type of imaging to be executed; and a display unit 12 which reads out the content of the description by the operator corresponding to the acquired imaging type from the memory 21 and displays said content.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

47.

Sample pretreatment device

      
Application Number 29856464
Grant Number D1030089
Status In Force
Filing Date 2022-10-13
First Publication Date 2024-06-04
Grant Date 2024-06-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Tsukamoto, Yuji

48.

DATA PROCESSING SYSTEM

      
Application Number 18204413
Status Pending
Filing Date 2023-06-01
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Kawase, Tomohiro

Abstract

A data processing system (1) including a data holder (8) that holds analysis data including mass spectrometry data acquired by a mass spectrometer (100) in an analysis of a sample using a chromatograph mass spectrometer and measurement data acquired by a detector, that is not mass spectrometer, in the analysis of the sample, a data processor (10) configured to perform data processing by using the analysis data held in the data holder (8), and an information displayer (12) configured to display data processed by the data processor (10). The data processor (10) is configured to create a chromatogram based on the measurement data, and identify a peak portion in which peaks of a plurality of components overlap to form one peak shape among peak portions on the chromatogram as a coelution peak by using a correspondence relationship between the chromatogram and the mass spectrometry data, and when displaying the chromatogram, the information displayer (12) is configured to display a peak portion identified as the coelution peak by the data processor (10) in a mode different from that of another peak portion.

IPC Classes  ?

49.

Method for Detecting Coronavirus Infection

      
Application Number 18281094
Status Pending
Filing Date 2022-03-09
First Publication Date 2024-05-30
Owner
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japan)
  • SHIMADZU CORPORATION (Japan)
  • AiSTI SCIENCE Co., Ltd. (Japan)
Inventor
  • Tomizawa, Kazuhito
  • Nagayoshi, Yu

Abstract

An object of the present invention is to provide a method for determining that a subject is at risk of suffering or is suffering from COVID-19. The present invention provides a method for determining whether a subject that is a mammal is at risk of suffering or suffering from COVID-19, the method including a step of detecting the amount of at least one modified nucleoside selected from the group consisting of 6-threonylcarbamoyl adenosine (t6A) and 2-thiomethyl,6-threonylcarbamoyl adenosine (ms2t6A) in a sample derived from the subject.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

50.

MASS SPECTROMETER AND MASS SPECTROMETRY METHOD

      
Application Number 18283605
Status Pending
Filing Date 2021-12-23
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Takahashi, Hidenori

Abstract

The precursor ion is reacted with ammonia molecules or ammonia radicals to generate product ions, the product ions are separated according to a mass-to-charge ratio, and detected. It is estimated that whether or not an aldehyde group is included in a molecular structure of the precursor ion based on a difference between a mass-to-charge ratio of one of the detected product ion and a mass-to-charge ratio of the precursor ion. In addition, provided is a mass spectrometer (1) including: a reaction chamber (132) to which the precursor ions are introduced; an ammonia supply part (5) configured to supply ammonia molecules or ammonia radicals to the reaction chamber; and separation and detection parts (142, 143, 144, and 145) configured to separate product ions generated from the precursor ion by reaction with the ammonia molecules or ammonia radicals according to a mass-to-charge ratio, and to detect the product ions.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/02 - Particle spectrometers or separator tubes - Details
  • H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers

51.

METHOD FOR CREATING CALIBRATION CURVE AND METHOD FOR MEASURING AMYLOID ß-RELATED PEPTIDE

      
Application Number 18285134
Status Pending
Filing Date 2022-02-09
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Kaneko, Naoki

Abstract

Included is the steps of providing a plurality of standard solutions containing amyloid β-related peptide and a surfactant and having different concentrations of the amyloid β-related peptide; mixing a solution containing internal standard peptide with each of the plurality of standard solutions; performing immunoprecipitation and mass spectrometry on a plurality of calibration curve solutions; standardizing signal intensity (A) in the amyloid β-related peptide with the signal intensity (B) in the internal standard peptide for each of the plurality of calibration curve solutions; and calculating a regression equation of a calibration curve based on a plurality of normalized intensities and the concentration of the amyloid β-related peptide.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard

52.

ANALYSIS SYSTEM

      
Application Number 18370275
Status Pending
Filing Date 2023-09-19
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Hinooka, Motomu

Abstract

The analysis system is provided with a placement member and an arm mechanism. The placement member has a positioning portion for defining a position of a sample container on a placement surface. The arm mechanism moves the sample container placed on the placement member to the positioning portion to thereby place the sample container at a reference position on the placement member.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

53.

METHOD AND DEVICE FOR PROCESSING MASS SPECTROMETRY DATA

      
Application Number 18473700
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kunimura, Yoshihiro
  • Uchiyama, Kosuke

Abstract

Provided is a method for processing mass spectrometry data by which the task of analyzing data of mass spectra acquired by a mass spectrometric analysis of an analysis target sample can be efficiently performed. The method includes the steps of: preparing data of a plurality of MS/MS spectra for each of one or more compounds contained in a sample, each of the MS/MS spectra acquired by an MS/MS scan measurement using each of a plurality of different precursor ions originating from the same compound (Steps 1-3); and creating data of a merged MS/MS spectrum for each of the one or more compounds by merging the data of the plurality of MS/MS spectra acquired by the MS/MS scan measurement using the plurality of precursor ions originating from the compound concerned (Step 6).

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes

54.

SPECTRUM ANALYSIS SYSTEM AND SPECTRUM ANALYSIS METHOD

      
Application Number 18518965
Status Pending
Filing Date 2023-11-25
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Fuji, Risa
  • Murakami, Sachio
  • Iwasaki, Shoko

Abstract

This spectrum analysis system has a measurer, a display, and a controller that displays plurality of first anomaly items that indicate the type of anomaly in appearance of the measurement spectrum waveform. The controller displays the first reference spectrum waveform for reference to a mode of appearance of the anomaly corresponding to each of the plurality of first anomaly items in the display.

IPC Classes  ?

55.

ANALYSIS APPARATUS

      
Application Number 18522404
Status Pending
Filing Date 2023-11-29
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka, Hiroto

Abstract

An analysis apparatus according to this invention includes a measurer configured to measure a sample; a temperature adjuster configured to adjust a temperature of the sample during measurement; a display configured to display information: and a controller configured to control a function of displaying an interface on the display as the information, wherein the interface includes the followings: a plurality of items including temperature and time, and a graphic schematic diagram representing a thermal cycle with time and visualizing the plurality of items on the thermal cycle.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 1/28 - Preparing specimens for investigation
  • G06T 11/20 - Drawing from basic elements, e.g. lines or circles

56.

DATA ANALYSIS SYSTEM, ANALYSIS DATA DISPLAY APPARATUS AND DATA DISPLAY METHOD IN DATA ANALYSIS SYSTEM

      
Application Number 18516034
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-05-30
Owner Shimadzu Corporation (Japan)
Inventor
  • Sawada, Ryuji
  • Ono, Takeshi

Abstract

A data analysis system according to this invention includes a data acquirer, a storage configured to store to-be-analyzed data items and analysis modules linked with top hierarchical data items, an analyzer, a display, and a controller configured to direct the display to display the to-be-analyzed data items and/or the analysis modules that are linked with the top hierarchical data item(s) whose access right (s) is/are provided to a user in the hierarchical structure, and to exclude the to-be-analyzed data items and the analysis modules that are linked with the top hierarchical data item(s) whose access right (s) is/are not provided to the user from items to be displayed on the display.

IPC Classes  ?

  • G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
  • G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
  • G06F 18/231 - Hierarchical techniques, i.e. dividing or merging pattern sets so as to obtain a dendrogram

57.

INFRARED RAMAN DEVICE

      
Application Number 18520342
Status Pending
Filing Date 2023-11-27
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Tao, Tomoyo
  • Sasayama, Tomoki
  • Shibutani, Ryuta
  • Otaguro, Atsuhiko
  • Katsutani, Fumiya

Abstract

An infrared Raman device is capable of switching and performing Raman measurement and first infrared measurement on a sample. The infrared Raman device includes an objective lens for Raman measurement; a first observation lens for infrared measurement; a laser light source that generates laser light; a first infrared light source that generates first infrared light; and a mirror. The mirror is disposed at time of the Raman measurement to reflect the laser light to cause the laser light to pass through the objective lens for Raman measurement and reflect Raman light generated from the sample by the laser light that passes through the objective lens for Raman measurement and radiated to the sample. The Raman light passes back through the objective lens for Raman measurement.

IPC Classes  ?

  • G01J 3/44 - Raman spectrometry; Scattering spectrometry
  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
  • G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry

58.

Display screen or portion thereof with graphical user interface of x-ray computed tomography device

      
Application Number 29845345
Grant Number D1029009
Status In Force
Filing Date 2022-07-06
First Publication Date 2024-05-28
Grant Date 2024-05-28
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Nakagawa, Hironobu
  • Matsumoto, Noriko
  • Harada, Daisuke
  • Keyaki, Yasuyuki
  • Kikuchi, Takahiro

59.

AROMA DESIGNER

      
Application Number 019031556
Status Pending
Filing Date 2024-05-24
Owner Shimadzu Corporation (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory gas chromatograph systems; gas chromatograph-mass spectrometers.

60.

AROMA DESIGNER

      
Serial Number 98567056
Status Pending
Filing Date 2024-05-24
Owner SHIMADZU CORPORATION (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory gas chromatograph systems, gas chromatograph-mass spectrometers

61.

Learning Data Creation Method and Learning Data Creation Device

      
Application Number 18282755
Status Pending
Filing Date 2021-10-05
First Publication Date 2024-05-23
Owner SHIMADZU CORPORATION (Japan)
Inventor Sakai, Takero

Abstract

The present disclosure provides a method for creating learning data to be used for creating a discriminator discriminating target samples having attributes different from each other.

IPC Classes  ?

62.

PUMP UNIT FOR CHROMATOGRAPH

      
Application Number 18384843
Status Pending
Filing Date 2023-10-28
First Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Fujiwara, Masanori
  • Nakamura, Takafumi
  • Iijima, Yuki
  • Wada, Kosuke

Abstract

A pump unit for a chromatograph includes a plunger pump and an upstream check valve. The plunger pump has a pump head and pumps a mobile phase. The upstream check valve is provided upstream of the pump head. The upstream check valve includes a flow-path portion and a temperature regulator. The flow-path portion guides the mobile phase to the plunger pump. The temperature regulator regulates a temperature of the mobile phase passing through the flow-path portion.

IPC Classes  ?

  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
  • G01N 30/20 - Injection using a sampling valve

63.

ANALYTE SPECIMEN ANALYSIS DEVICE, AND CALIBRATION CURVE GENERATION METHOD

      
Application Number JP2023039656
Publication Number 2024/101274
Status In Force
Filing Date 2023-11-02
Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sugiyama, Kiyohiro
  • Matsumoto, Junichi
  • Sudo, Tomokazu

Abstract

This analyte specimen analysis device (100) comprises: an analyte measurement unit (1) that measures an analyte specimen; a calibration curve generation unit (30) that, on the basis of measurement data (20) for the analyte specimen which was acquired by the analyte measurement unit, generates a calibration curve (21) to be used in an analysis of the analyte specimen; and a display unit (2) that displays at least a measurement condition (22a) of a blank specimen (90) which does not include a substance under investigation.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

64.

METHOD FOR MEASUREMENT OF NICOTINAMIDE MONONUCLEOTIDE (NMN) AND ITS RELATED METABOLITES

      
Application Number US2023079385
Publication Number 2024/103005
Status In Force
Filing Date 2023-11-10
Publication Date 2024-05-16
Owner
  • WASHINGTON UNIVERSITY (USA)
  • SHIMADZU CORPORATION (Japan)
Inventor
  • Imai, Shin-Ichiro
  • Unno, Junya
  • Ogura, Tairo
  • Nishimura, Masayuki

Abstract

The present disclosure is generally directed to methods and kits for measurement of nicotinamide mononucleotide (NMN) and its related metabolites in biological samples. The present disclosure is further directed to a method for calculating recovery efficiency of Nicotinamide mononucleotide (NMN) in a sample. The methods use a liquid chromatography-tandem mass spectrometry (LC-MS/MS)- driven methodology and double isotopic NMN standards. These methods and kits can be used for the study of nicotinamide adenine dinucleotide (NAD+) metabolism and aging.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • C07H 19/048 - Pyridine radicals
  • G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

65.

MASS SPECTROMETER

      
Application Number JP2023032730
Publication Number 2024/100977
Status In Force
Filing Date 2023-09-07
Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Terashima, Kenta
  • Kasamatsu, Satoshi

Abstract

Provided is a mass spectrometer (1) in which a first ion source (12) to (17) that atomizes a liquid sample under an atmospheric pressure to ionize the liquid sample and a second ion source (111) that emits laser beam to the sample to ionize the sample are attached alternatively as an ionization section, the mass spectrometer (1) being further provided with: a mass analysis section (231), (242) to (246) which is disposed in a vacuum chamber connected to the ionization section through a partitioning wall and separates and detects ions in accordance with mass-to-charge ratios thereof; a second ion introduction tube (31), (36) which is longer than a first ion introduction tube and is used when the second ion source is used, in which the first ion introduction tube is disposed through the partitioning wall and through which ions are introduced into the vacuum chamber and us used when the first ion source is used; and a heating section (37), (38) which heats a part of the second ion introduction tube which extends from the first ion introduction tube toward the ionization section side.

IPC Classes  ?

  • H01J 49/10 - Ion sources; Ion guns
  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

66.

Display screen or portion thereof with transitional graphical user interface of x-ray imaging device

      
Application Number 29843670
Grant Number D1026938
Status In Force
Filing Date 2022-06-23
First Publication Date 2024-05-14
Grant Date 2024-05-14
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Harada, Daisuke
  • Keyaki, Yasuyuki
  • Kikuchi, Takahiro
  • Matsumoto, Noriko
  • Nakagawa, Hironobu

67.

FLAME ATOMIC ABSORPTION PHOTOMETER

      
Application Number JP2023020679
Publication Number 2024/095514
Status In Force
Filing Date 2023-06-02
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Iwai, Nobuyuki
  • Kobayashi, Tomoari
  • Kimoto, Takuya
  • Kobayashi, Osuke

Abstract

The present invention provides a flame atomic absorption photometer comprising: a burner 110 that forms a flame by burning a mixture of an atomized sample liquid and a mixed gas including a fuel gas and a combustion-assisting gas; flame light detection units 181, 182 that detect light radiated from the flame; and an expired flame determination unit 162 that determines that the flame has gone out when the intensity of the light detected by the flame light detection units is lower than a predetermined threshold value. The flame light detection units selectively detect light having a wavelength of 290 nm to 330 nm inclusive.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • F23N 5/08 - Systems for controlling combustion using devices responsive to thermal changes or to thermal expansion of a medium using light-sensitive elements
  • G01N 21/72 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using flame burners

68.

FLUORESCENT X-RAY ANALYSIS METHOD, ANALYSIS PROGRAM, AND FLUORESCENT X-RAY ANALYSIS DEVICE

      
Application Number JP2023028689
Publication Number 2024/095551
Status In Force
Filing Date 2023-08-07
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ogawa, Rie
  • Ochi, Hirotomo

Abstract

CRC/RC/R), which is the ratio of the measured intensity of the Rayleigh scattering line to the measured intensity of the Compton scattering line is obtained (S3). The thickness of the thin film and the contained amounts of respective elements constituting the target sample are determined by the fundamental parameter method on the basis of the measured scattering intensity ratio of the target sample (S5-S11).

IPC Classes  ?

  • G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

69.

METHOD FOR ESTIMATING METABOLIC FLUX DISTRIBUTION, ANALYSIS DEVICE, AND PROGRAM

      
Application Number JP2023030109
Publication Number 2024/095564
Status In Force
Filing Date 2023-08-22
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kusanagi, Toshihiro
  • Aisu, Ryota
  • Tagawa, Yusuke

Abstract

Provided is a method for estimating the metabolic flux distribution of cells, the method comprising: a step for acquiring discharge data including time-series data of a substance discharged to the outside of the cells with respect to a first strain cell and a second strain cell that is a reference for comparison; a step for calculating a discharge flux of the substance to the outside of the cells on the basis of the discharge data; a step for estimating a plurality of primary flux patterns on the basis of the discharge flux; and a step for clustering the plurality of primary flux patterns on the basis of the mutual similarity of the plurality of primary flux patterns and then outputting the clustered result.

IPC Classes  ?

  • G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

70.

IMAGING ANALYSIS DEVICE AND IMAGING DATA ANALYSIS METHOD

      
Application Number 17768404
Status Pending
Filing Date 2019-11-14
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor Yamaguchi, Shinichi

Abstract

An imaging analysis device according to the present invention includes: an analysis execution unit (1) configured to perform analysis by a predetermined analysis method for each of a plurality of measurement points set in a measurement area on a sample and collect imaging data; a reference image acquiring unit (2) configured to acquire a reference image for the measurement area; a regression analysis executer (36) configured to, with respect to the imaging data and the reference image obtained for the same sample, perform predetermined regression analysis calculation with the imaging data as an explanatory variable and data constituting the reference image as a target variable and acquire a regression model; and a predicted image creator (37) configured to apply, to the regression model, imaging data obtained by the analysis execution unit using a sample different from the sample used in the regression analysis executer, and create a predicted image based on a pseudo regression analysis result.

IPC Classes  ?

71.

ANALYSIS DEVICE

      
Application Number 18278616
Status Pending
Filing Date 2021-12-21
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Araki, Takahisa
  • Nagasao, Kota

Abstract

A driving part of an analysis device includes a cylindrical part on one surface of which a moving mirror is fixed, and a VCM connected at another surface of the cylindrical part and reciprocating the cylindrical part. The VCM includes: a yoke in a cylindrical shape; magnets provided at two ends of the yoke; a fixing part which is in a cylindrical shape enclosing the yoke and fixes, at a bottom surface, the yoke provided with the magnets; a lid part provided with windows and covering an opening surface of the fixing part; a moving part which is arranged between the yoke and the fixing part and on which a coil in a cylindrical shape is fixed; and support parts each including one end fixed to the moving part and another end connected at the another surface of the cylindrical part through the window.

IPC Classes  ?

72.

PREPARATIVE LIQUID CHROMATOGRAPH

      
Application Number 18279822
Status Pending
Filing Date 2021-11-08
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Tamaoki, Soichiro
  • Yamazaki, Tomoyuki
  • Sato, Shohei

Abstract

A separation channel on which a liquid delivery pump, a separation column, and a detector are provided, the liquid delivering pump being for feeding a mobile phase, the separation column being for separating a component in a sample, and the detector being for detecting peaks of components separated from each other by the separation column, a plurality of liquid handlers each including an injecting part and a collecting part, wherein when one of the plurality of liquid handlers is introduced into the separation channel, the injecting part of the one of the plurality of liquid handlers functions as an injector that executes injection operation of a sample into a mobile phase flowing through the analysis channel upstream of the separation column in the analysis channel and the collecting part of the one the plurality of liquid handlers functions as a fraction collector that executes collection operation of peaks of components separated from each other in the separation column, a selector for selectively switching a liquid handler to be introduced into the separation channel among a plurality of the liquid handlers, and a controller for controlling operation of a plurality of the liquid handlers and the selector.

IPC Classes  ?

73.

METHOD FOR MASS SPECTROMETRY AND CHROMATOGRAPH MASS SPECTROMETER

      
Application Number 18382398
Status Pending
Filing Date 2023-10-20
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ueda, Manabu
  • Fujita, Shinjiro
  • Taniguchi, Junichi

Abstract

For a low-cost, high-accuracy tuning of the voltages applied to electrodes in a mass spectrometer, a chromatograph mass spectrometer (1) includes: a medium supplier (11) which supplies a medium as a mobile phase or carrier gas; a passage (15) which introduces, into the mass spectrometer, the medium supplied from the medium supplier; an ionizer (211) which ionizes the medium together with a substance coming from a member forming the passage into the medium; a measurement executer (25, 26, 43) which performs a mass separation and a measurement of a specific ion, using multiple measurement conditions which differ from each other in the value of voltage applied to at least one electrode included in one or more electrodes in the mass spectrometer; and a voltage value determiner (44) which determines the value of voltage applied to each electrode so that the intensity of the ion satisfies a predetermined criterion.

IPC Classes  ?

  • G01N 30/72 - Mass spectrometers
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

74.

MICRO-RAMAN DEVICE

      
Application Number 18382930
Status Pending
Filing Date 2023-10-23
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Shibutani, Ryuta

Abstract

A micro-Raman device includes a first laser light source, a second laser light source, a first holder, a second holder, a first ND filter, and a second ND filter. The first laser light source and the second laser light source generate first laser light of a first wavelength and second laser light of a second wavelength, respectively. The second wavelength is different from the first wavelength. The first laser light and the second laser light proceed in a second direction orthogonal to a first direction while being separated from each other in the first direction. The first holder and the second holder are arranged overlapping each other in the second direction.

IPC Classes  ?

75.

MASS SPECTROMETER

      
Application Number 18382955
Status Pending
Filing Date 2023-10-23
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Matsushita, Tomoyoshi

Abstract

Provided is a mass spectrometer including a vacuum chamber containing a cell used for causing ions originating from a sample to come in contact with a predetermined gas supplied from a gas supplier (20), which includes a three-way valve (204) configured to selectively send the gas into either a first passage (22) for sending the predetermined gas to the cell or a second passage (23) for discharging the gas into vacuum state. The mass spectrometer also includes a controller configured to control the three-way valve so as to send the gas into the second passage during an analysis period in which ions are not caused to come in contact with the gas within the cell and/or during a non-analyzing period, as well as to send the gas into the first passage during an analysis period in which ions are caused to come in contact with the gas within the cell.

IPC Classes  ?

  • H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
  • H01J 49/10 - Ion sources; Ion guns
  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

76.

MASS SPECTROMETER AND METHOD FOR SETTING ANALYSIS CONDITION

      
Application Number 18383919
Status Pending
Filing Date 2023-10-26
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Matsushita, Tomoyoshi

Abstract

An ICP-MS includes a control device, a collision cell and a first electrode that are provided on an optical axis of plasma, and a second electrode, a mass separation device, and a detector that are provided on a detection axis. The control device sets, as an axis-shifting voltage to be applied to each electrode of the first electrode and the second electrode in a gas-present mode, the voltage obtained by adding an offset determined according to a mass-to-charge ratio of a target ion to an initial voltage in a gasless mode.

IPC Classes  ?

77.

MICRO-RAMAN APPARATUS AND METHOD FOR CONTROLLING MICRO-RAMAN APPARATUS

      
Application Number JP2023036490
Publication Number 2024/090177
Status In Force
Filing Date 2023-10-06
Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Furuta, Tetsuro
  • Fujiwara, Naoya
  • Moritani, Yuka

Abstract

A micro-Raman apparatus (100) comprises a light source unit (110), an objective lens unit (140), a detection device (160), a drive device (180), and a control device (200) for controlling the drive device (180). The light source unit (110) includes a plurality of light source devices (111-114) configured so as to generate mutually different wavelengths of light. The objective lens unit (140) condenses and radiates light from the light source unit (110) to a sample (SMP) to be analyzed. The detection device (160) detects Raman scattered light generated from the sample (SMP). The drive device (180) changes a relative distance between the sample (SMP) and the objective lens unit (140). The control device (200) is configured so as to correct the relative distance in accordance with the wavelength of light radiated from the light source device that is used.

IPC Classes  ?

78.

Infectious Disease Testing Method

      
Application Number 18279339
Status Pending
Filing Date 2021-06-18
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Yasojima, Makoto
  • Takemori, Hiroaki
  • Daigo, Fumi
  • Tomono, Takuya

Abstract

The present disclosure provides a test method for assessing the possibility of infection of residents without performing periodic PCR tests of residents of a facility in question. One embodiment is an infectious disease test method that includes a sampling step for collecting a sample from sewage during a sampling period in a route from where sewage is discharged from a facility until flowing into a public sewage pipe, an analysis step for analyzing the sample to obtain information relating to the existence of an infectious disease pathogen in the sample, and a notification step for notifying the facility of the information together with the sampling period.

IPC Classes  ?

  • G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials

79.

ANALYZING METHOD FOR RNA

      
Application Number 18494008
Status Pending
Filing Date 2023-10-25
First Publication Date 2024-05-02
Owner Shimadzu Corporation (Japan)
Inventor Fukuyama, Yuko

Abstract

[OBJECT] To enable a more sensitive and uniform detection of a molecular-related ion in an analysis of an RNA contained in a sample by means of MALDI mass spectrometry. [OBJECT] To enable a more sensitive and uniform detection of a molecular-related ion in an analysis of an RNA contained in a sample by means of MALDI mass spectrometry. [MEANS FOR SOLVING PROBLEM] A mixed matrix containing 2,4-dihydroxyacetophenone (DHAP) and 2,4,6-trihydroxyacetophenone monohydrate (THAP) is used as a matrix to analyze an RNA contained in a sample by a matrix-assisted laser desorption/ionization mass spectrometer.

IPC Classes  ?

  • C12Q 1/6872 - Methods for sequencing involving mass spectrometry
  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

80.

GAS CHROMATOGRAPH ASSISTANCE DEVICE AND GAS CHROMATOGRAPH ASSISTANCE METHOD

      
Application Number 18378558
Status Pending
Filing Date 2023-10-10
First Publication Date 2024-04-18
Owner Shimadzu Corporation (Japan)
Inventor Fukushima, Daiki

Abstract

A GC assistance device includes a saving amount evaluator, a consumption amount evaluator and an outputter, and is used together with a gas chromatograph. The saving amount evaluator evaluates a saving amount of a resource caused by stopping of the gas chromatograph. The consumption amount evaluator evaluates a consumption amount of the resource caused by recovery of the gas chromatograph from a stop state. The outputter presents an evaluation value in regard to the saving amount and the consumption amount to a user. Alternatively, the outputter controls an operation state of the gas chromatograph based on the evaluation value.

IPC Classes  ?

  • G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

81.

FLOW RATE SWITCHING MECHANISM AND MASS SPECTROMETER

      
Application Number 18485311
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Shiba, Shunki
  • Matsushita, Tomoyoshi

Abstract

A flow rate switching mechanism including: a first section including: a first housing with a passage internally bored through, the passage having a narrowed portion at a distance from one end of the passage, and the narrowed portion having a smaller cross-sectional area than the cross-sectional area of the passage at the one end; a capillary having an internal passage having a smaller cross-sectional area than the cross-sectional area of the narrowed portion; and a hermetic support member supporting the capillary and to provide a seal; a second section having a second housing identical in shape to the first housing, without having the capillary and the hermetic support member; and a three-way valve being alternatively switchable between a first state in which the outlet end is connected to the first inlet end and a second state in which the outlet end is connected to the second inlet end.

IPC Classes  ?

  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
  • F25B 41/42 - Arrangements for diverging or converging flows, e.g. branch lines or junctions
  • H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

82.

TREATMENT DEVICE

      
Application Number JP2022038157
Publication Number 2024/079837
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

A treatment device (1) is provided with: a vessel (50) for containing a sample; pipes (11-13) for introducing, into the vessel, a treatment liquid for decomposing an impurity contained in the sample; a port (64) that discharges, from the vessel containing the sample, a liquid contained in the sample as waste liquid; a pump (33) connected to the port; and a control device (500) for controlling the pump. The control device controls the pump so as to enable a predetermined amount or more of the waste liquid to be discharged from the port.

IPC Classes  ?

  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting
  • B03D 1/14 - Flotation machines

83.

DIAGNOSIS SUPPORT METHOD, DIAGNOSIS SUPPORT PROGRAM, AND DIAGNOSIS SUPPORT SYSTEM

      
Application Number JP2023026093
Publication Number 2024/079957
Status In Force
Filing Date 2023-07-14
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Hirose, Ryuta
  • Hasegawa, Yukinori
  • Nakaya, Tomohiro
  • Uno, Haruo
  • Oyama, Shintaro
  • Nakagawa, Yasunobu
  • Yagi, Tetsuya
  • Iguchi, Mitsutaka

Abstract

Provided is a diagnosis support system that acquires one or more items of patient information associated with a patient (steps S30, S40), and inputs the one or more items into an estimation model and acquires, from a plurality of diseases, a candidate for a disease that the patient may have (step S50). The diagnosis support system then acquires additional required information to be additionally acquired from the patient on the basis of the candidate for the disease (step S70). The diagnosis support system then presents the additional required information (step S90).

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

84.

QUALITY CONTROL STANDARD SOLUTION USED IN PEPTIDE ASSAY, AND QUALITY CONTROL OF PEPTIDE ASSAY

      
Application Number 18278094
Status Pending
Filing Date 2022-02-02
First Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Yoda, Ritsuko

Abstract

A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of Aβ1-42 (SEQ ID NO.: 9), Aβ1-38 (SEQ ID NO.: 11), Aβ1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-Aβ1-42, SIL-Aβ1-38, SIL-Aβ1-40, and SIL-APP669-711.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 30/02 - Column chromatography
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

85.

RECOVERY IMPLEMENT AND RECOVERY SYSTEM

      
Application Number JP2022038155
Publication Number 2024/079835
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

This recovery implement (100) recovers subject material contained in a discharged liquid that is discharged from each of a plurality of treatment devices (1A, 1B, 1C) for treating samples. The recovery implement comprises: a plurality of filtration units (110A, 110B, 110C) that are provided corresponding to the plurality of treatment devices, the filtration units filtering the discharged liquid that is discharged from the corresponding treatment devices and extracting the subject material contained in the discharged liquid; a holder (101) that integrally accommodates the plurality of filtration units; and a discharge unit (102) that discharges a waste liquid that has passed through each of the plurality of filtration units. The holder can be detached from the discharge unit together with the plurality of filtration units in which the subject material resides.

IPC Classes  ?

  • B01D 29/90 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor having feed or discharge devices for feeding
  • B01D 29/01 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor with flat filtering elements
  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting

86.

PROCESSING DEVICE, PROCESSING METHOD, AND CONTROL PROGRAM

      
Application Number JP2022038156
Publication Number 2024/079836
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

A processing device (1) comprises: a container (50) that accommodates a specimen; a control device (500) that extracts a target substance from the specimen accommodated in the container; and an input device (505) that receives input from a user. The control device performs a refresh process in which a first processing liquid for processing a contaminant included in the specimen is introduced into the container in which the specimen is accommodated, and after the first processing liquid has been introduced, on the basis of an input to the input device, a second processing liquid for re-processing the contaminant included in the specimen is introduced into the container.

IPC Classes  ?

  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting
  • B03D 1/14 - Flotation machines

87.

METHOD FOR FILLING HEAT TRANSPORT DEVICE WITH REFRIGERANT AND REFRIGERANT FILLING CONTROL DEVICE FOR HEAT TRANSPORT DEVICE

      
Application Number JP2023036301
Publication Number 2024/080213
Status In Force
Filing Date 2023-10-05
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sekimoto, Shunsuke
  • Horiguchi, Yukio
  • Matsuda, Shotaro
  • Nishiura, Yoshiaki

Abstract

This method for filling a heat transport device (110) with a refrigerant comprises: a pre-filling step (step 902) for filling a refrigerant flow path (10) of a heat transport device (110) with an inactive gas such that the pressure inside the refrigerant flow path (10) of the heat transport device (110) reaches a prescribed pressure; and a main filling step (step 904) for filling the refrigerant flow path (10) of the heat transport device (110) with a refrigerant to a prescribed quantity necessary for operating the heat transport device (110), after the pre-filling step (step 902).

IPC Classes  ?

  • F25B 45/00 - Arrangements for charging or discharging refrigerant
  • F25B 1/00 - Compression machines, plants or systems with non-reversible cycle
  • F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes

88.

FLOW PATH STATE OUTPUT DEVICE

      
Application Number JP2023036580
Publication Number 2024/080246
Status In Force
Filing Date 2023-10-06
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Shimizu, Satoshi
  • Morita, Daisuke

Abstract

A computer according to an embodiment of this flow path state output device is connected to a liquid chromatograph and obtains the result of analysis processing performed by the liquid chromatograph. The computer comprises a feature amount acquisition unit and a state output unit. The feature amount acquisition unit measures a sample containing a known component by means of an analysis device, and obtains a feature amount from the measurement result. The state output unit outputs the flow path state of the liquid chromatograph to a display on the basis of the feature amount.

IPC Classes  ?

  • G01N 30/86 - Signal analysis
  • G01N 30/26 - Conditioning of the fluid carrier; Flow patterns
  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed

89.

ELEM-SPOT

      
Application Number 019012917
Status Pending
Filing Date 2024-04-12
Owner Shimadzu Corporation (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Gas Chromatograph; Mass Spectrometer with an element-selective combustion unit included for selectively analyzing nitrogen-containing compounds or oxygenated compounds in complex hydrocarbon compounds with high sensitivity.

90.

TIME-OF-FLIGHT MASS SPECTROMETRY DEVICE AND ANALYSIS METHOD

      
Application Number 17768747
Status Pending
Filing Date 2020-08-17
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kishida, Takuro
  • Aoki, Yasushi
  • Kawai, Toshitaka

Abstract

A time-of-flight mass spectrometry device includes an electrode to which a DC high voltage is applied in order to form an ion flight space and a high voltage power supply device that applies the high voltage to the electrode. The high voltage power supply device includes a high voltage generating circuit that generates the high voltage, and a voltage control circuit that is selectively set to a convergence responsiveness priority mode in which the high voltage generating circuit is controlled such that the high voltage has first convergence responsiveness and first stability or a stability priority mode in which the high voltage generating circuit is controlled such that the high voltage has second convergence responsiveness that is lower than the first convergence responsiveness and second stability that is higher than the first stability.

IPC Classes  ?

  • H01J 49/40 - Time-of-flight spectrometers
  • H01J 49/02 - Particle spectrometers or separator tubes - Details

91.

AIR MEASUREMENT METHOD USING GAS CHROMATOGRAPH AND GAS CHROMATOGRAPH ANALYSIS SYSTEM

      
Application Number 18276858
Status Pending
Filing Date 2021-09-22
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Uchiyama, Shinji

Abstract

An air measurement method of performing measurement by injecting air into a gas chromatograph includes a liquid suction step of sucking a liquid that does not interfere with detection of a predetermined component in air by a gas chromatograph into a syringe to fill the syringe with the liquid, an air suction step of sucking a predetermined amount of air into the syringe after the liquid suction step, an injection step of injecting the predetermined amount of air sucked into the syringe into the gas chromatograph after the air suction step, and a recording step of acquiring a detection signal for the air injected into the gas chromatograph in the injection step and recording an acquired detection signal in association with the air injection amount into the gas chromatograph.

IPC Classes  ?

  • G01N 30/18 - Injection using a septum or microsyringe

92.

ELEM-SPOT

      
Serial Number 98495847
Status Pending
Filing Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Gas chromatograph mass spectrometer with an element-selective combustion unit included for selectively analyzing nitrogen-containing compounds or oxygenated compounds in complex hydrocarbon compounds with high sensitivity

93.

METHOD FOR ANALYZING DATA ACQUIRED BY MALDI MASS SPECTROMETRY, DATA-PROCESSING DEVICE, MASS SPECTROMETER, AND DATA-ANALYZING PROGRAM

      
Application Number 17960609
Status Pending
Filing Date 2022-10-05
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Teramoto, Kanae

Abstract

A method for analyzing MALDI mass spectrometry data includes: calculating m/z values respectively corresponding to peaks in amass spectrum, from data corresponding to the mass spectrum acquired by MALDI mass spectrometry performed on a sample; and performing at least one of calculations (a) and (b), based on the m/z values and information on kinds of ions possibly generated from the sample in the mass spectrometry, where calculation (a) includes assuming that ions respectively corresponding to the peaks are first ions singly charged, and calculating m/z of second ions respectively corresponding to the first ions and being multiply charged, and calculation (b) includes assuming that ions respectively corresponding to the peaks are first ions that are multiply charged ions, and calculating m/z of second ions respectively corresponding to the first ions and being singly charged.

IPC Classes  ?

  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/40 - Time-of-flight spectrometers

94.

Estimation Device, Learning Device, Optimization Device, Estimation Method, Learning Method, and Optimization Method

      
Application Number 18275969
Status Pending
Filing Date 2022-01-31
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Suzuki, Takashi
  • Yamamoto, Shuhei
  • Toyoda, Kenichi
  • Kuroda, Hirotaka

Abstract

An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.

IPC Classes  ?

  • G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G16C 20/70 - Machine learning, data mining or chemometrics
  • G16C 20/80 - Data visualisation

95.

BIOCHEMICAL ANALYSIS APPARATUS AND BIOCHEMICAL ANALYSIS METHOD

      
Application Number 18388745
Status Pending
Filing Date 2023-11-10
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Onoki, Takanori
  • Sugiyama, Kiyohiro

Abstract

A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

96.

METHOD AND DEVICE FOR SUGGESTING POSITIONING OF ELECTROMAGNETIC SENSORS, AND CURRENT SOURCE LOCATION ESTIMATION METHOD

      
Application Number JP2023035835
Publication Number 2024/075669
Status In Force
Filing Date 2023-10-02
Publication Date 2024-04-11
Owner
  • SHIMADZU CORPORATION (Japan)
  • RIKEN (Japan)
Inventor
  • Gomi, Tomohiro
  • Tomita, Sadamu
  • Umebayashi, Ryu
  • Yamashita, Okito
  • Takeda, Yusuke

Abstract

This method for suggesting the positioning of electromagnetic sensors involves suggesting the positioning of a plurality of electromagnetic sensors positioned on the surface of a living body around a target region inside a subject, using a forward model for estimating electromagnetic fields produced at the positions of the plurality of electromagnetic sensors by biological activity inside the subject, the method including: a step for setting calculation conditions including the position of the target region and the positions at which the plurality of electromagnetic sensors can be positioned; a step for calculating, on the basis of the calculation conditions that have been set, suggested positioning for all or some of the plurality of electromagnetic sensors, which are for estimating the position of a current source inside the subject; and a step for outputting the suggested positioning.

IPC Classes  ?

  • A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents

97.

CALIBRANT FOR USE IN MASS SPECTROMETER AND METHOD FOR PRODUCING SAME

      
Application Number 18276323
Status Pending
Filing Date 2022-02-02
First Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Nishikaze, Takashi
  • Kaneko, Naoki

Abstract

A calibrant for use in correction of machine difference of mass spectrometers and a method for producing the calibrant are provided. A calibrant for use in a mass spectrometer, the calibrant comprising not less than two calibration substances, wherein a ratio of, relative to a concentration of one calibration substance of the not less than two calibration substances, a concentration of another calibration substance of the not less than two calibration substances is a predetermined value, and a method for producing the calibrant.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes

98.

ANALYSIS SYSTEM

      
Application Number JP2023016614
Publication Number 2024/070027
Status In Force
Filing Date 2023-04-27
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Yonekura Takuya

Abstract

An analysis system (1) comprises an analysis device (100) that analyzes samples. At least one of the constituent elements of the analysis device (100) is a temperature adjustment constituent element (106; 108) that includes a temperature adjustment element (112; 116) and a temperature sensor (112; 116). The temperature adjustment constituent element (106; 108) must perform temperature control by using the temperature adjustment element (112, 116) and the temperature sensor (112, 116) and stabilize the temperature at a set target temperature at the time of starting the analysis. The analysis device (100) enters an analysis-enabled state in which analysis can be started when the temperatures of all the temperature adjustment constituent elements (106; 108) stabilize at the temperature set for each. The analysis system (1) comprises: a time measurement unit (202) that is configured to measure, as stabilization times, the time required from the start of the temperature control until output of the temperature sensor (112; 116) stabilizes, every time the temperature control is executed; a data accumulation unit (204) that is configured to store and accumulate the stabilization times, which are measured by the time measurement unit (202) each time the temperature control is executed, in association with conditions that affect the stabilization times when the temperature control is executed; and a time prediction unit (206) that is configured to calculate a predicted value of the time required for the analysis device (100) to enter the analysis-enabled state, by using a large number of compatible stabilization times, from among the stabilization times accumulated by the data accumulation unit (204), in which the associated conditions are compatible with the conditions at the time of the setting, when the settings for the analysis are made.

IPC Classes  ?

99.

MASS SPECTROMETER AND POWER SUPPLY DEVICE

      
Application Number 18447640
Status Pending
Filing Date 2023-08-10
First Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Mizutani, Shiro

Abstract

A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/02 - Particle spectrometers or separator tubes - Details
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

100.

X-RAY PHASE IMAGING DEVICE AND X-RAY PHASE IMAGING ANALYSIS METHOD

      
Application Number JP2023028534
Publication Number 2024/070230
Status In Force
Filing Date 2023-08-04
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Doki, Takahiro
  • Kimura, Kenji
  • Morimoto, Naoki
  • Nagai, Ishikawa, Lisa

Abstract

This X-ray phase imaging device (100) comprises: an X-ray light source (10), an X-ray detector (11), a plurality of lattices; a rotary mechanism (15) which rotates a subject (90) including fibers (91a) and the plurality of lattices relative to each other; an image processing unit (2a) which generates a plurality of X-ray phase contrast images (40) for each of the orientations of the subject with respect to the plurality of lattices; and a control unit (2b) which acquires orientation information (30) pertaining to the orientations of fibers included in the subject on the basis of the plurality of X-ray phase contrast images, and acquires a feature amount (31) pertaining to the mechanical strength of the subject.

IPC Classes  ?

  • G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers
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