Methods are provided for performing a surgical procedure using optical coherence tomography (OCT) including extracting lenticular material from within a capsular bag of the eye of a patient; placing a replacement lens within the capsular bag after extraction of the lenticular material from the capsular bag; acquiring a plurality of OCT images that visualize the placement of the replacement lens within the capsular bag; and determining from the plurality of OCT images a degree of contact of the posterior surface of the replacement lens with the posterior portion of the capsular bag.
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61F 9/008 - Methods or devices for eye surgery using laser
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
2.
Microscopes including illumination field diaphragms
Surgical microscopes are provided including at least one ocular, an objective lens; a collimated space between the at least one ocular and the objective lens; an illumination system optically coupled into the collimated space of the surgical microscope, wherein an illumination from the illumination system is directed along a path at least partially contained within the collimated space of the surgical microscope and through the objective lens; and one of a field diaphragm and obscuration mask positioned within the illumination system, and outside of a field of view of the at least one ocular, wherein the one of the field diaphragm and the obscuration mask blocks, attenuates or diverts rays from the illumination system that reflect from a surface of the objective lens such that the reflected rays are not visible through the at least one ocular.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
Methods are provided including obtaining at least one image of a surgical region of a subject oriented for the surgical procedure using an OCT imaging system. An initial structural view of the surgical region to be used during the surgical procedure is constructed based on the obtained at least one OCT image. Parameters are computed as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image. The surgical procedure is periodically assessed and clinical outcomes are monitored using changes to the OCT-derived initial structural view of the surgical region or changes to the computed at least one clinical parameter. It is determined if the surgical plan needs modification and it is modified during the surgical procedure. Operations repeat until it is determined that no more modifications are needed.
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61F 9/008 - Methods or devices for eye surgery using laser
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
7.
Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products
OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion (590) configured to be received by the surgical microscope; and a non-circularly symmetric mask portion (591( integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion configured to be received by the surgical microscope; and a non-circularly symmetric mask portion integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.
Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror. The at least one actuator receives a first instruction set from the microcontroller in the form of sequential commands and a second instruction set from the FPGA in the form of concurrent commands. The first instruction set establishes a pattern of motion of the at least one steerable mirror at least partially responsive to inputs from the user interface of the communications device. The second instruction set modifies an attribute of the pattern of motion of the at least one steerable mirror in substantially real-time at least partially responsive to one or more triggering events.
Methods for performing a surgical procedure using optical coherence tomography (OCT) are provided. The method includes extracting lenticular material from within a capsular bag of an eye of a patient; acquiring at least one OCT image of an interior region of the capsular bag after extraction of substantially all of the lenticular material from within the capsular bag; determining from the at least one OCT image the presence of cellular debris remaining within the interior of the capsular bag; and extracting at least a portion of the remaining cellular debris from the interior of the capsular bag.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
Scanning optical beam imaging systems for imaging extended structures of an eye and providing biometry of an eye are provided. The systems include a focal system for shifting the focus of the scanning system from the front to the back of the eye. The systems provide for converging rays that can scan through the pupil of the eye, enabling scanning of the anterior and posterior segments of the eye using a common objective and a fixed working distance.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
G02B 13/18 - Optical objectives specially designed for the purposes specified below with lenses having one or more non-spherical faces, e.g. for reducing geometrical aberration
G02B 15/16 - Optical objectives with means for varying the magnification by axial movement of one or more lenses or groups of lenses relative to the image plane for continuously varying the equivalent focal length of the objective with interdependent non-linearly related movements between one lens or lens group, and another lens or lens group
16.
Surgical microscopes using optical coherence tomography and related systems
Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
18.
Immersion lens assemblies for use in optical coherence tomography systems
An optical coherence tomography (OCT) measurement system for precision measurement of a translucent sample is provided. The system includes an optical coherence tomography (OCT) imaging system comprising a broadband light source, a reference path with reference path length, and sample path with a beam scanning assembly and an imaging lens assembly; a sample positioning assembly including an immersion bath for positioning the translucent sample within an immersion bath; a position assembly for locating the translucent sample within a field of view (FOV) of the OCT imaging system; an immersion lens assembly associated with the imaging lens assembly configured to eliminate an air to bath refractive interface between a distal surface of the OCT imaging lens including an immersion tip and a surface of the bath; a first set of calibration parameters that relate a position of a scanning beam at an imaging plane to drive signals of the scanning assembly; and a second set of calibration parameters for relating an optical path length or optical path length variation of the scanning beam at an imaging plane to the position of the scanning beam or to the drive signals of the scanning assembly.
Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
20.
Optical systems for whole eye imaging and biometry
Scanning optical beam imaging systems for imaging extended structures of an eye and providing biometry of an eye are provided. The systems include a focal system for shifting the focus of the scanning system from the front to the back of the eye. The systems provide for converging rays that can scan through the pupil of the eye, enabling scanning of the anterior and posterior segments of the eye using a common objective and a fixed working distance.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
G02B 15/16 - Optical objectives with means for varying the magnification by axial movement of one or more lenses or groups of lenses relative to the image plane for continuously varying the equivalent focal length of the objective with interdependent non-linearly related movements between one lens or lens group, and another lens or lens group
21.
Image registration, averaging, and compounding for high speed extended depth optical coherence tomography
An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.
Methods of acquiring an image are provided. The methods include deriving a first boundary surface from a volumetric image; deriving a second boundary surface, different and spaced apart from the first boundary surface, of the volumetric image, the first and second boundary surfaces defining a slice of the volumetric image therebetween; and deriving at least one intermediate thin section between the first and second boundary surfaces, the thin section having a thickness that is less than a thickness of the slice of the volumetric image defined by the first and second boundary surfaces. Systems and computer program products are also provided.
Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.
Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens. The coupling element has first and second faces, the first face positioned toward the oculars of the surgical microscope and the second face positioned toward the subject. The coupling element is configured to receive a heads up optical display signal at the first face of the coupling element and reflect the signal in a wavelength band of the heads up display module; and receive a signal on the second face of the coupling element and reflect the signal in a wavelength band of the OCT system.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
G02B 27/14 - Beam splitting or combining systems operating by reflection only
Methods for performing a surgical procedure using optical coherence tomography (OCT) are provided. The method includes orienting the subject for the surgical procedure, wherein orienting comprises imaging a region of the subject that contains a structure having a known orientational asymmetry, testing the image for the presence and location of the structure, and confirming correct orientation of the subject using the OCT image of the structure having the known orientational asymmetry; obtaining at least one image of the surgical region of the subject using OCT and constructing an initial structural view of the surgical region; computing at least one clinical parameter relevant as an end point for assessing the outcome of the surgical procedure using data derived from the OCT image; periodically assessing a surgical process and monitoring clinical outcomes related to the surgical procedure using changes to the OCT-derived structural view of the surgical region OCT or the changes to the computed clinical parameters derived from the at least an OCT image; determining if a surgical plan for the surgical procedure needs modification based on the periodic assessment and/or monitoring; modifying the surgical plan for the surgical procedure if it is determined modification is needed; and repeatedly assessing and monitoring, determining and modifying until it is determined that modification is not needed.
A61F 9/008 - Methods or devices for eye surgery using laser
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
26.
Procedural optical coherence tomography (OCT) for surgery and related methods
Methods are provided including obtaining at least one image of a surgical region of a subject oriented for the surgical procedure using an OCT imaging system. An initial structural view of the surgical region to be used during the surgical procedure is constructed based on the obtained at least one OCT image. Parameters are computed as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image. The surgical procedure is periodically assessed and clinical outcomes are monitored using changes to the OCT-derived initial structural view of the surgical region or changes to the computed at least one clinical parameter. It is determined if the surgical plan needs modification and it is modified during the surgical procedure. Operations repeat until it is determined that no more modifications are needed.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61F 9/008 - Methods or devices for eye surgery using laser
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
27.
OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND OPTICAL LASER SCANNING SYSTEM COMPRISING BEAM SHAPING OPTICAL SYSTEM WITH A LENS TRIPLET, WHERE SECOND AND THIRD LENS ARE MOVABLE
An optical coherence tomography (OCT) imaging system and an laser scanning system are provided. The OCT system is provided with: a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. In the saser scanning system is also provided with a beam shaping optical assembly being configured to receive optical radiation from a laser source. The beam shaping optical assembly of both systems includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.
G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.
Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
34.
Optical coherence tomography (OCT) imaging systems for use in ophthalmic applications
Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Systems for imaging structures of a subject are provided. The subject has an optical axis, a pupil, and a nodal point. The system includes an image capture device; a first structure including a mount for the subject to be imaged by the image capture device, the first structure providing at least two rotational degrees of freedom; a second structure including a mount for the image capture device, the second structure providing at least two translational degrees of freedom; and a means for aligning the image capture device in relation to the optical axis, the pupil, and the nodal point of the subject.
Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
G02B 11/02 - Optical objectives characterised by the total number of simple and compound lenses forming the objective and their arrangement having two lenses only
37.
Surgical microscopes using optical coherence tomography and related methods
Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.
Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.
Scanning optical beam imaging systems for imaging a surface with convex curvature are provided. The systems include a sphero-telecentric objective, wherein a scanning radius of curvature of the sphero-telecentric objective is greater than an apical radius of curvature of the surface and less than or equal to four times an apical radius of curvature of the surface.
Scanning optical beam imaging systems for imaging a surface with convex curvature are provided. The systems include a sphero-telecentric objective, wherein a scanning radius of curvature of the sphero-telecentric objective is greater than an apical radius of curvature of the surface and less than or equal to four times an apical radius of curvature of the surface.
Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/125 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
44.
Systems for extended depth frequency domain optical coherence tomography (FDOCT) and related methods
Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
Systems for imaging structures of a subject are provided. The subject has an optical axis, a pupil, and a nodal point. The system includes an image capture device; a first structure including a mount for the subject to be imaged by the image capture device, the first structure providing at least two rotational degrees of freedom; a second structure including a mount for the image capture device, the second structure providing at least two translational degrees of freedom; and a means for aligning the image capture device in relation to the optical axis, the pupil, and the nodal point of the subject.
Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.
Wavenumber linear spectrometers ( 310 ) are provided including an input ( 312 ) configured to receive electromagnetic radiation from an external source; collimating optics ( 314 ) configured to collimate the received electromagnetic radiation; a dispersive assembly ( 330 ) including first and second diffractive gratings ( 320, 322 ), wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly ( 318 ) configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array ( 320 ) such that the variation in frequency spacing along the linear detection array is no greater than about 10%.
Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path (201) defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path (202) defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path (203) defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element (207) in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane (206). Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
50.
Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection
Methods of collapsing volume data to a lower dimensional representation of the volume data are provided. The methods include collapsing volume data to a lower dimensional representation of the volume data using histogram projection. Related systems and computer program products are also provided.
Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.
Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
G07C 9/00 - Individual registration on entry or exit
53.
Systems for comprehensive fourier domain optical coherence tomography (FDOCT) and related methods
Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.
Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
56.
SYSTEMS FOR EXTENDED DEPTH FREQUENCY DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) AND RELATED METHODS
Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
A61B 3/117 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
57.
Systems for imaging structures of a subject and related methods
Systems for imaging structures of a subject are provided. The subject has an optical axis, a pupil, and a nodal point. The system includes an image capture device; a first structure including a mount for the subject to be imaged by the image capture device, the first structure providing at least two rotational degrees of freedom; a second structure including a mount for the image capture device, the second structure providing at least two translational degrees of freedom; and a means for aligning the image capture device in relation to the optical axis, the pupil, and the nodal point of the subject.
Optical coherence tomography (OCT) imaging systems for imaging uniquely identifiable structure are provided including a source having an associated source arm path and having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. Processing methods to convert the depth-dependent image data to a uniquely identifiable code are provided. Related methods and computer program products are also provided.
A Spectrometer is provided including a camera and an axial symmetric camera mount configured to receive the camera and to rotate. The spectrometer furthers include an input for providing optical radiation to a spectrometer system; a diffraction grating for dispersing the optical radiation along a prescribed plane; at least one lens for focusing wavelength-dispersed light onto at least one array of a detector of optical radiation, wherein the camera has at least one linear array of elements for detecting optical radiation; a mechanical housing, wherein the axial symmetric camera mount is configured to couple the camera to the mechanical housing; and a means for rotating the camera coupled to the mechanical housing about an axis. Related systems and methods are also provided.
A Spectrometer is provided including a camera and an axial symmetric camera mount configured to receive the camera and to rotate. The spectrometer furthers include an input for providing optical radiation to a spectrometer system; a diffraction grating for dispersing the optical radiation along a prescribed plane; at least one lens for focusing wavelength-dispersed light onto at least one array of a detector of optical radiation, wherein the camera has at least one linear array of elements for detecting optical radiation; a mechanical housing, wherein the axial symmetric camera mount is configured to couple the camera to the mechanical housing; and a means for rotating the camera coupled to the mechanical housing about an axis. Related systems and methods are also provided.
Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
62.
Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products
OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
64.
OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING SYSTEMS HAVING ADAPTABLE LENS SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS
OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
65.
METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR MIXED-DENSITY OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING
Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.
Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.
Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.
Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
70.
METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR REMOVING UNDESIRED ARTIFACTS IN FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) SYSTEMS USING CONTINUOUS PHASE MODULATION AND RELATED PHASE MODULATORS
Methods, fourier domain optical coherence tomography (FDOCT) interferometers and computer program products are provided for removing undesired artifacts in FDOCT systems using continuous phase modulation. A variable phase delay is introduced between a reference arm and a sample arm of an FDOCT interferometer using continuous phase modulation. Two or more spectral interferograms having different phase delay integration times are generated. The spectral interferograms are combined using signal processing to remove the undesired artifacts. Systems and methods for switching between stepped and continuous phase shifting Fourier domain optical coherence tomography (FDOCT) and polarization-sensitive optical coherence tomography (PSOCT) are also provided herein.
Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated. The acquired raw spectral data and the postulated trial spectral phase data are assembled into trial complex spectrum data. Trial A-scan data is computed by performing an inverse Fourier transform on the trial complex spectrum data and determining the magnitude of a result.
Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired (600) for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated (610). The acquired raw spectral data and the postulated trial spectral phase data are assembled into trial complex spectrum data (620). Trial A-scan data is computed by performing an inverse Fourier transform on the trial complex spectrum data and determining the magnitude of a result (630).
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
Some embodiments of the present invention provide optical coherence tomography systems including an OCT engine and a processor. The OCT engine is configured to provide both standard OCT imaging and spectral domain phase microscopy (SDPM) imaging. The processor is coupled to the OCT engine and is configured to use a first signal processing method when the OCT engine is configured to provide standard OCT imaging and a second signal processing method when the OCT engine is configured to provide SDPM imaging. Related methods are also provided.
Optical imaging systems are provided including a light source and a depolarizer. The light source is provided in a source arm of the optical imaging system. A depolarizer is coupled to the light source in the source arm of the optical imaging system and is configured to substantially depolarize the light from the light source. Related methods and controllers are also provided.
Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
77.
OPTICAL COHERENCE IMAGING SYSTEMS HAVING A REDUCED EFFECTIVE LINEWIDTH AND METHODS OF USING THE SAME
Frequency domain optical coherence imaging systems have an optical source, an optical detector and an optical transmission path between the optical source and the optical detector. The optical transmission path between the optical source and the optical detector reduces an effective linewidth of the imaging system. The optical source may be a broadband source and the optical transmission path may include a periodic optical filter.
METHODS, SYSTEMS AND COMPUTER PROGRAMM FOR 3D-REGISTRATI0N OF THREE DIMENSIONAL DATA SETS OBTAINED BY PREFERABLY OPTICAL COHERENCE TOMOGRAPHY BASED ON THE ALIGNMENT OF PROJECTION IMAGES OR FUNDUS IMAGES, RESPECTIVELY
Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified in the second VIP image. The first and second VIP images are aligned based on the one or more first landmarks in the first and second VIP images to locate a subject area of the first three dimensional data set in the second three dimensional data set so as to allow comparison of the sublect area in the first and second three dimensional data sets at the respective first and the times. Related systems and computer program products are also provided.
Methods of analyzing three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified and registered in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified and registered in the second VIP image. The first and second VIP images are aligned based on the registered one or more first landmarks in the first and second VIP images. Related systems and computer program products are also provided.
patents
