METHOD OF GUIDING MULTIPLE DETAILED PERFORMANCE EXPERIMENTS REQUIRED FOR DEVELOPING REAGENT FOR DETECTING TARGET NUCLEIC ACID MOLECULE, AND ORGANIZING EXPERIMENT RESULT RECORD SHEETS
This method of guiding multiple detailed performance experiments required for developing a reagent for detecting a target nucleic acid molecule, and organizing experiment result record sheets is performed by a computer device and comprises the steps of: providing a data input screen for at least one requirement item selected from among requirement items for performing an experiment, including a material, a method, equipment, and a combination thereof which are used for each detailed performance experiment to be performed on oligonucleotide for detecting the target nucleic acid molecule; displaying preparation information for a reaction plate for performing, by a nucleic acid detection device, an amplification reaction on the oligonucleotide on the basis of the data input via the data input screen; receiving result data of the amplification reaction performed by the nucleic acid detection device by using an amplification composition containing the oligonucleotide, on the basis of the preparation information; processing/analyzing the received result data of the amplification reaction to obtain data; and storing the data input via the data input screen, the preparation information, the amplification reaction result, and the processed/analyzed data as an experiment result record sheet for each detailed performance experiment.
The present invention relates to a composition for detecting target nucleic acids, comprising two probes having different Tm values and capable of hybridizing adjacently on the target nucleic acid, and to a method for detecting n target nucleic acids in a sample using the composition for detecting target nucleic acids, whereby the present invention allows for the real-time detection of a plurality of target nucleic acids using a single type of marker, offering improved convenience, and high cost-effectiveness and efficiency.
In an embodiment of the disclosure, a computer-implemented method for predicting a dimerization in a nucleic acid amplification reaction comprises accessing a dimer prediction model learned by a transfer learning method; providing an input data to the dimer prediction model, wherein the input data comprise a sequence data of an oligonucleotide; and obtaining a prediction result for the dimerization of the oligonucleotide from the dimer prediction model.
An assembly-type molecular diagnostic system according to an embodiment comprises: a preparation device for carrying out preparatory work for the detection of target nucleic acid molecules; a detection device for carrying out detection operations for the target nucleic acid molecules; and a display that shows a device marking indicating the preparation device and a device marking indicating the detection device, wherein the device markings display the status of the device indicated by each device marking or information about the tasks being performed by each device in a predetermined order.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
5.
TUBE TRANSPORT DEVICE AND PRODUCTION AUTOMATION SYSTEM INCLUDING TUBE TRANSPORT DEVICE
A tube transport device may include: a first conveyor on which a tube is transported; a second conveyor located at a lower level than the first conveyor; and a slide structure which is located between the first conveyor and the second conveyor and includes a guiding body which guides a tube provided on the first conveyor to slide down and a control unit which controls the slid-down tube to be selectively provided to the second conveyor.
B65G 47/90 - Devices for picking-up and depositing articles or materials
B65G 47/26 - Devices influencing the relative position or the attitude of articles during transit by conveyors arranging the articles, e.g. varying spacing between individual articles
B65G 47/88 - Separating or stopping elements, e.g. fingers
B65G 47/82 - Rotary or reciprocating members for direct action on articles or materials, e.g. pushers, rakes, shovels
B65G 47/57 - Devices for transferring articles or materials between conveyors, i.e. discharging or feeding devices to or from inclined or vertical conveyor sections for articles
6.
MOLECULAR DIAGNOSTIC DEVICE, AND METHOD FOR CONTROLLING OPERATION THEREOF
One embodiment provides a method for controlling the operation of a molecular diagnostic device. The molecular diagnostic device includes a sample preparation device, a sample analysis device, and a computer device, and the method comprises the steps of: executing, on the computer device, a drive-controlling software module of the sample preparation device and/or the sample analysis device, wherein during execution of the drive-controlling software module, the computer device is provided with a user interface (U/I) capable of receiving an input of a handling operation by a user; and allowing, during execution of the drive-controlling software module, the handling operation to be performed on the U/I by a command pre-programmed in the computer device.
The present invention relates to a method and computing apparatus for testing a community group for an infectious disease and notifying the test results, and relates to a method and computing apparatus for testing a community group for an infectious disease and notifying the test results so that infectious disease tests are more efficiently conducted and managed within each community group for individuals living in a group at a workplace, a church, a nursing home, or the like.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
A method of providing an interface for setting the threshold value of an amplification characteristic parameter, according to an embodiment of the present invention, may comprise the steps of: acquiring, from detection data acquired in a detection process for a target analyte in each of a plurality of samples, measurement values for n (where n is an integer of 2 or more) types of amplification characteristic parameters for each of the plurality of samples, each of the plurality of samples being pre-labeled as any one of a positive sample and a negative sample; respectively displaying the plurality of samples at locations determined by the n types of measurement values in an n-dimensional coordinate system space comprising axes respectively corresponding to the n types of amplification characteristic parameters; displaying, by using the pre-labeled results, whether each of the plurality of samples displayed in the n-dimensional coordinate system space is positive or negative; and displaying a screen for setting the threshold value for each of the n-types of amplification characteristic parameters.
An apparatus for suppling product boxes may comprise: a loading unit which loads product boxes; a discharge unit which is disposed below the loading unit and discharges the product boxes; a rotation guide structure which is disposed below the discharge unit, supports, in a first mode, a product box located at a first position of the discharge unit from among the product boxes, and guides, in a second mode, the product box such that the product box rotates while the product box located at the first position of the discharge unit falls; and a conveyor which is disposed below the rotation guide structure and on which the rotated product box is provided.
B65G 47/06 - Devices for feeding articles or materials to conveyors for feeding articles from a single group of articles arranged in orderly pattern, e.g. workpieces in magazines
B65G 59/06 - De-stacking from the bottom of the stack
10.
METHOD FOR OBTAINING APPROXIMATE SIGNAL FOR EACH OF MULTIPLE TARGET ANALYTES, AND COMPUTER DEVICE FOR PERFORMING SAME
Provided is a method for obtaining an approximate signal for a target analyte, the method comprising the step of obtaining, from a signal generation reaction of multiple cycles targeting a first target analyte and a second target analyte in a sample, a first data set measured at a first detection temperature of each of the multiple cycles and a second data set measured at a second detection temperature of each of the multiple cycles, and performing joint-estimation for (a) an approximation function parameter value and (b) a size parameter value by at least partially using the first data set and the second data set, the approximation function parameter value being included in at least one approximation function selected from the group consisting of a (1-1)th approximation function that approximates a signal value at the first detection temperature dependent on the presence of the first target analyte, a (1-2)th approximation function that approximates a signal value at the second detection temperature dependent on the presence of the first target analyte, and a second approximation function that approximates a signal value at the second detection temperature dependent on the presence of the second target analyte, the size parameter value representing a relationship between the sizes of a signal value dependent on the presence of the first target analyte, respectively showing at the first detection temperature and at the second detection temperature.
A medical record acquisition device for distributing information is provided. The medical record acquisition device according to one embodiment comprises a memory that stores at least one instruction, and a processor, wherein the processor is capable of: obtaining payment details for a payment at a medical institution among payment details of a payer by executing the at least one instruction; by using name information of the medical institution included in the payment details for the payment at the medical institution, obtaining medical institution identification information for the medical institution at which the payment was made from a medical institution information management server that matches name information for each of a plurality of medical institutions with medical institution identification information and stores same; and obtaining a medical record of a patient having received treatment, from the medical institution corresponding to the obtained medical institution identification information.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06F 21/30 - Authentication, i.e. establishing the identity or authorisation of security principals
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
12.
AUTOMATED SAMPLE POOLING SYSTEM AND SAMPLE POOLING METHOD USING SAME
The present invention relates to a sample pooling method using an automated sample pooling system, comprising the steps of: arranging a plurality of pooling chambers and sample containers; associating the sample containers having a predetermined pool size with the pooling chambers, respectively; and providing, to the pooling chambers, pooled samples in which samples of pool sizes are combined, by transferring samples from the sample containers to the associated pooling chambers by using sample transfer tools.
The present invention relates to a method for amplifying a target nucleic acid using beta-hydroxy acid, and in particular, a loop-mediated isothermal amplification (LAMP) method. The beta-hydroxy acid used in the method according to the present invention can not only reduce the time required for the LAMP reaction by improving the amplification rate of the target nucleic acid, but can also reduce the probability of a false positive by suppressing non-specific amplification.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
14.
METHOD AND DEVICE FOR CREATING TECHNICAL CONSTRUCTION FILE
A computer-implemented method for creating a technical construction file for a reagent for detecting target nucleic acid molecules according to an embodiment disclosed herein, comprises the steps of: providing a screen for inputting items commonly corresponding to at least two of a plurality of detailed performance experiments for the reagent for detecting target nucleic acid molecules; receiving inputs of content for the commonly corresponding items all at once, wherein the technical construction file includes two or more detailed performance documents including the two or more detailed performance experiments; and exporting the commonly corresponding items and the received content for the commonly corresponding items to the two or more detailed performance documents, and thereby creating the two or more detailed performance files.
A well-plate sealing apparatus according to the present invention comprises: a magazine which can accommodate overlapping sheets; a pickup unit which picks up an uppermost sheet in the magazine; a tray on which a well-plate is arranged; a sheet transport unit which transports the sheet that is picked up to a placing position; and a sealing unit which seals wells in the well-plate with a sheet, wherein the placing position is a position where the pickup sheet is placed on the well-plate that is arranged on the tray.
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
B65B 41/06 - Feeding sheets or wrapper blanks by grippers by suction-operated grippers
B65B 57/04 - Automatic control, checking, warning or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages and operating to control, or to stop, the feed of such material, containers, or packages
B65H 3/08 - Separating articles from piles using pneumatic force
16.
METHOD FOR CONTROLLING DISPLAYING OF MOLECULAR DIAGNOSTIC RESULTS AND COMPUTER DEVICE FOR PERFORMING SAME
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
17.
METHOD FOR PREPARING REACTION MIXTURE FOR NUCLEIC ACID AMPLIFICATION REACTION IN SAMPLE BY USING SAMPLE HANDLING SYSTEM
The present invention relates to a method for preparing a reaction mixture for a nucleic acid amplification reaction in a sample by using a sample handling system. More specifically, by preparing a nucleic acid amplification reaction by using a sample handing system, which utilizes two types of pipetting mechanism, and a specific nucleic acid extraction reagent, the time required for extracting a nucleic acid from a sample and mixing same with an amplification reagent can be significantly reduced, and consequently, efficiency of molecular diagnosis using a nucleic acid amplification reaction can be significantly improved.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
A nucleic acid detection cartridge according to the present invention comprises: a chamber body including a plurality of chambers provided on the upper surface; and a cover facing the upper surface of the chamber body, wherein at least one of the chamber body or the cover can move relative to the other in a plane direction parallel to the upper surface, and at least one of the chamber body or the cover can move relative to the other in a straight line at a certain angle with respect to the upper surface.
An embodiment of the present invention relates to a connection structure which connects a robot arm capable of three-axis movement to a dividing module that divides a solution into a preset amount, the connection structure comprising: a first member provided with a robot arm connection portion connected to the robot arm and a first axis connection portion protruding from the robot arm connection portion in a first direction; a second member provided with a dividing module connection portion which is coupled to the robot arm connection portion with a main shaft and connected to the dividing module, and a second axis connection portion protruding from the dividing module connection portion in the first direction; and a tilting member which has one end coupled to the first axis connection portion as a first axis and the other end coupled to the second axis connecting portion as a second axis, and tilts the second member by a certain angle with respect to the first member when dividing the solution. The tilting member is tilt-moved on the basis of the first axis while pushing the second axis, and the second member is tilt-moved on the basis of the main shaft when being pushed by the tilting member.
According to one embodiment, provided is a method by which a computer device estimates whether a plate used for nucleic acid amplification test is contaminated, comprising the steps of: acquiring a detection result for a target analyte of a plurality of wells in a plate; acquiring, from the detection result, location information about positive wells in the plate; and using at least some of the acquired location information so as to estimate whether the plate is contaminated.
The present method can detect three target nucleic acids in a real-time manner in one reaction vessel by signals measured at three temperatures using a single type of fluorescent labels. In contrast to conventional techniques that detect multiple target nucleic acid by melting analysis after target amplification, the present invention does not require melting analysis after target amplification, significantly reducing the analysis time.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
The present method allows for detection of at least nine HPV types in a real-time manner in one reaction vessel by analyzing signals measured at three temperatures using at least three different types of fluorescent labels. In particular, the method of the present invention can detect at least nine target nucleic acids in a real-time manner without performing a melting analysis.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
According to an embodiment of the present invention, there is provided a method method for providing a user interface on a user interface-providing device for operating a liquid handler to prepare a candidate composition to be tested to provide a nucleic acid amplification composition for detecting a target nucleic acid molecule,the method comprising: displaying an input screen for selecting types of tasks and a plurality of test items for preparing the candidate composition: displaying (i) a parameter defined by the selected task and the test item and (ii) an input screen for receiving the parameter value for the displayed parameter;receiving the parameter value; and transferring the received parameter value to the liquid handler, wherein the user interface-providing device communicates with the liquid handler such that the liquid handler is operated at least partially based on an instruction and a parameter value to be referenced upon execution of the instruction, wherein the test of the candidate composition is performed for at least one test item among the plurality of test items, wherein each of the plurality of test items is to test a detection performance of the candidate composition, and wherein the detection performance comprises a sensitivity and/or specificity for the target nucleic acid molecule.
DEVICE FOR DETERMINING PRESENCE/ABSENCE OF TARGET NUCLEIC ACID, METHOD FOR DETERMINING PRESENCE/ABSENCE OF TARGET BY THE DEVICE, SERVER FOR DISTRIBUTING UPDATE INFORMATION, AND METHOD FOR DISTRIBUTING UPDATE INFORMATION BY THE SERVER
A distribution server distributing update information is provided. A distribution server according to an embodiment comprises a communication unit communicating with a target presence/absence determining device in which a presence/absence determining process for a target nucleic acid is performed using a data set from a target nucleic acid amplification reaction, the analysis module referencing a parameter value in the presence/absence determining process, a memory storing at least one instruction, and a processor. The processor executes the at least one instruction to distribute the update information to the target presence/absence determining device through the communication unit to allow the target presence/absence determining device to assign the parameter value included in the update information to the parameter with no parameter value or assign the parameter value included in the update information to the parameter with a previously assigned parameter value.
The present invention relates to a film cutting apparatus and a method for cutting a container cover film using same. In particular, according to an embodiment of the present invention, a film cutting apparatus for cutting a cover film adhered to a container including a plurality of chambers which are connected to one another to be separatable, comprises: a base frame; a pressing module which is coupled to the base frame to be movable in the vertical direction, and is descended to press chambers located at both sides of the container downward; a transport module coupled to one or more of the pressing module and the base frame; and a cutting module coupled to the transport module, wherein the cutting module comprises a plurality of cutting means which can cut the cover film adhered to the container, and the transport module moves the cutting module in the longitudinal direction so that the cover film is cut while the pressing module presses the chambers of the container.
B65B 61/08 - Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for severing webs, or for separating joined packages by cutting using rotary cutters
B26D 1/14 - Cutting through work characterised by the nature or movement of the cutting member; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis with a circular cutting member, e.g. disc cutter
B26D 7/02 - Means for holding or positioning work with clamping means
B26D 5/02 - Means for moving the cutting member into its operative position for cutting
B26D 5/08 - Means for actuating the cutting member to effect the cut
26.
METHOD AND DEVICE FOR ANALYZING VARIANT TYPE OF ORGANISM
Disclosed is a method, performed by a computing device, for analyzing a variant type of an organism. The method may comprise the steps of: preparing a variant classification model trained with a plurality of data sets, wherein each of the plurality of data sets includes mutation information including one or more mutation identifiers and a variant type labeled therewith; providing a plurality of pieces of mutation information to the variant classification model to obtain a variant type of each of the plurality of pieces of mutation information; and calculating a degree of contribution of the at least one mutation identifier to the determination of each obtained variant type, on the basis of the plurality of pieces of mutation information and each obtained variant type thereof. A representative drawing may be figure 2.
According to an embodiment of the disclosure, a method for providing an interface for setting parameters, for a target analyte positive/negative result-determination process; the method comprising: displaying correct answer data for the positive/negative of the target analyte in a sample; displaying a pre-determined default value for a parameter used in the determination process; displaying a first determination result of the determination process to which the default value has been applied; receiving a setting value for the parameter; and displaying a second determination result of the determination process to which the setting value has been applied; wherein the determination process analyzes a signal obtained by a reaction of amplifying a nucleic acid as the target analyte.
The present disclosure relates to a method for detecting target nucleic acids in a sample. The method according to the present disclosure can rapidly detect target nucleic acids and has simplified protocols, and thus can be effectively applied to large hospitals, entrusted testing institutions, research laboratories, and the like at which molecular diagnosis for a large number of samples is required.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
The present invention relates to a uracil-DNA glycosylase (UDG) derived from a photobacterium leiognathi strain, and use thereof. A novel UDG of the present invention is an enzyme isolated from low-temperature bacteria photobacterium leiognathi, has an activity for decomposing a uracil base in a DNA substrate including uracil and is easily denatured at low temperature. Therefore, the UDG of the present invention allows carryover contamination occurring during nucleic acid amplification reactions to be removed, and thus can be effectively used for increasing accuracy (false positive elimination), purity and amplification efficiency of nucleic acid amplification reactions.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
C12N 15/52 - Genes encoding for enzymes or proenzymes
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
C07K 1/16 - Extraction; Separation; Purification by chromatography
30.
METHOD FOR PREDICTING PERFORMANCE OF DETECTION DEVICE
According to one embodiment of the present disclosure, a method for inferring a level of noise generated by a detection device for detecting presence/absence of a target analyte in a sample on the basis of a signal dependent on the presence/absence of the target analyte comprises the steps of: acquiring optic data having information about light from raw data used for optic calibration of the detection device; and using a pre-trained machine learning model into which the optic data has been input, so as to infer the level of noise generated by the detection device.
The present invention relates to a seal inspecting device. Specifically, an embodiment of the present invention may provide a container seal inspecting device comprising: an emitting part for emitting light along a light path extending in a first direction; a sensor part capable of sensing the light progressing along the light path; and a pressing module for pressing a seal of a container, wherein the pressing module includes a plurality of pressing units arranged on the light path, and the press units may be selectively placed at a first position blocking the light from reaching the sensor part and a second position allowing the light to reach the sensor part.
The present disclosure relates to a tagged loop primer comprising a single-stranded interactive double labeling system and an isothermal nucleic acid amplification method using same. It is easy to prepare the tagged loop primer for a loop-mediated isothermal amplification reaction of the present disclosure, and a single target nucleic acid as well as a plurality of target nucleic acids can be detected effectively and simultaneously by using the tagged loop primer of the present disclosure.
C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
33.
HIGH-THROUGHPUT ISOTHERMAL AMPLIFICATION METHOD USING AUTOMATED MOLECULAR DIAGNOSTIC SYSTEM
The present disclosure relates to a high-throughput isothermal amplification method using an automated molecular diagnostic system. The method according to the present disclosure can rapidly detect target nucleic acids from a large number of samples in a short time. Accordingly, the method can be usefully applied to large hospitals, entrusted testing institutions, research laboratories, etc. that require molecular diagnosis of a large number of samples.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
34.
METHOD FOR SELECTING SEQUENCE IDENTIFIER FOR DETECTION OF TARGET ANALYTE
Disclosed is a method, implemented by a computing device, for selecting a sequence identifier for detection of a target analyte. The method may comprise the steps of: acquiring a plurality of first identifiers belonging to the first hierarchy in which a target analyte is located on the biological classification system of organisms having a hierarchical structure; selecting second sequence identifiers among the first identifiers at least partially on the basis of the frequency of occurrence within the scope of the first hierarchy and the frequency of occurrence within the scope of a second hierarchy higher than the first hierarchy for each of the first sequence identifiers; and selecting third sequence identifiers associated with the target analyte from the second sequence identifiers at least partially on the basis of the frequency of occurrence within the scope of a third hierarchy higher than the second hierarchy and the frequency of occurrence within the scope of the first hierarchy for each of the first sequence identifiers. A representative figure may be figure 6.
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
The present invention relates to a thermal block for performing a plurality of reactions, the thermal block including an upper surface and a lower surface that are parallel to each other and have a length and width, wherein a plurality of sample wells open upwards are regularly arranged on the upper surface, a plurality of non-sample holes open upwards are formed on the upper surface, the plurality of non-sample holes include: (i) first non-sample holes in which an upper surface opening is shorter in the longitudinal direction and equal to or longer in the width direction than the diameter of the sample wells; and (ii) second non-sample holes formed shorter in the width direction and equally or longer in the longitudinal direction, the first non-sample holes are located between sample wells adjacent in the longitudinal direction, and the second non-sample holes are located between sample wells adjacent in the width direction.
The present invention relates to a sample collecting swab tool and a method for the detection of respiratory pathogens. The present invention relates to a swab tool in which two positions for gripping the swab tool, that is, two gripping points, are formed so as to make it easy to precisely control the force on the swab tool according to the sample collection site (e.g., nasal cavity or oral cavity), whereby swab samples can be collected from sample collection sites accurately and easily in an amount sufficient enough to detect respiratory pathogens. In addition, the swab tool of the present invention can be used not only for sampling by experts but also for self-sampling by non-experts, and respiratory pathogens can be detected from collected samples.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61B 5/08 - Measuring devices for evaluating the respiratory organs
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
A positive/negative reading device according to one embodiment of the present invention may comprise: an input unit for receiving a signal value in each of a plurality of cycles, from signal generation reactions of the plurality of cycles targeting a target assay substance, wherein the signal generation reactions generate signals dependent on the presence of the target assay substance in a sample; and a pre-learned positive/negative reading unit for estimating the presence of the target assay substance in the sample, from the signal value of each of the plurality of cycles and the order of each of the plurality of cycles.
The present invention relates to a method for processing and analyzing a sample in a molecular diagnostic system including a plurality of devices. According to a processing and analysis method of the present invention, a reaction container moves between a sample analysis unit and a sample preparation unit through two locally open local openings, and the possibility of contamination occurrence inside the sample analysis unit and the sample preparation unit can be minimized by providing a gate-type local opening.
A target analyte detection apparatus according to the present invention comprises: a sample holder, which can accommodate a sample; a light-emitting module, which can emit excitation light at the sample accommodated in the sample holder; and a detection module, which can detect emission light emitted from the sample, wherein the light-emitting module includes a light source element for generating excitation light, and a total internal reflection (TIR) lens for guiding the excitation light.
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
G02B 7/00 - Mountings, adjusting means, or light-tight connections, for optical elements
G02B 9/04 - Optical objectives characterised both by the number of the components and their arrangements according to their sign, i.e. + or – having two components only
The present disclosure relates to detection of a target nucleic acid sequence by using a synthetic non-natural base-bearing tag oligonucleotide. The protocol of the present disclosure improves binding affinity or specificity for hybridization between a target-dependent fragment and a fragment-hybridizing oligonucleotide to increase a target signal, thereby enabling the detection of a target sequence with improved sensitivity.
The present invention relates to a method of generating an individual-directed information record sheet, and relates to a method of receiving time-series information input by an individual, and generating an information record sheet.
G06F 40/103 - Formatting, i.e. changing of presentation of documents
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
The present invention relates to a thermal block for performing a plurality of reactions, comprising an upper surface and a lower surface, which are parallel and have a length and a width, having a plurality of sample wells formed on the upper surface and opened upward, and having, at the lower surface, a stepped surface and a barrier for accommodating a phase change material.
The present invention relates to a sample collection device comprising: (a) a first tube for accommodating a sample, the first tube including an open end portion; (b) a second tube for accommodating a sample transport medium, the second tube including an open end portion; and (c) an adapter, wherein the adapter includes: a first accommodation part formed such that the open end portion of the first tube is inserted therein; a second accommodation part coupled to the open end portion of the second tube; and a sealing part, which includes a first surface facing the first accommodation part and a second surface facing the second accommodation part and divides the first accommodation part from the second accommodation part, and the sealing part has a fracture line for fracturing the sealing part by means of contact pressure.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
44.
METHOD FOR PREPARING CALIBRATION PLATE FOR NUCLEIC ACID REACTION DETECTION DEVICE
The present invention relates to a calibration plate for a nucleic acid reaction detection device, a calibration kit comprising same, and a method for preparing same.
An assembled analysis system according to an embodiment comprises: a preparation device for preparing an analysis sample in a reaction vessel; a transfer module for transferring the reaction vessel in which the analysis sample is prepared; and a system control module for storing a file in which driving software for the preparation device is installed and state information of the transfer module is recorded. Here, the driving software is provided with an API for reading files, the driving software reads the files stored in the system control module using the API for reading files, and the state information is identified from the read file.
The present disclosure provides a method and a system for determining the height of a solution in a container in order to amplify and detect a target nucleic acid, the method comprising the steps of: using an illuminator to emit infrared light at the container, which is a colored container; using a detector comprising a photosensor, so as to sense the infrared light passing through the container and refracted, the detector being arranged in the direction of sensing the refracted infrared light; using the sensed refracted infrared light so as to acquire an image; and analyzing the acquired image so as to determine the height of the solution in the container.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
The present invention is a technology related to an automated analysis system using individually operated biological devices, an analysis method and a storage medium, the system allowing independently driven devices to operate together with an automated analysis system through the operative connection thereof so that an analysis sample can be prepared and analyzed.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
48.
DETECTION OF MULTIPLE TARGET NUCLEIC ACID USING MULTIPLE DETECTION TEMPERATURES
The present disclosure pertains to a method for detecting multiple target nucleic acids by a single type of label alone in a single reaction vessel by using multiple detection temperatures, which is characterized by providing a signal change dependent on the presence of a corresponding target nucleic acid at a corresponding detection temperature of each of the target nucleic acids. The conventional techniques using a single type of label is subjected to melting analysis after target amplification so as to detect multiple target nucleic acids. In contrast, the present method does not require melting curve analysis after target amplification, even using a single type of label, and thus can remarkably reduce the analysis time.
Provided is a mobile structure for diagnosis. A housing has a space therein to accommodate diagnostic equipment, with a housing open area being formed in the housing. A front room part is connected to peripheral portions of the housing open area to seal the housing open area and provides a size-variable front room to a portion of the space of the housing.
A61G 10/02 - Treatment rooms for medical purposes with means to maintain a desired pressure, e.g. for germ-free rooms
E04H 1/12 - Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
E04H 3/08 - Hospitals, infirmaries, or the like; Schools; Prisons
B60P 3/14 - Vehicles adapted to transport, to carry or to comprise special loads or objects the object being a workshop for servicing, for maintenance, or for carrying workmen during work
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
Provided is a method and system for determining a magnetic bead concentration in a suspension according to the disclosure, including irradiating a plurality of different wavelengths of light to a suspension in which magnetic beads are suspended, measuring the intensities of a plurality of reflected light beams at the different wavelengths reflected from magnetic beads, and determining the concentration of the magnetic beads from the measured intensities of the reflected light beams at the different wavelengths.
A self-sampling management electronic device includes a memory stores instructions and at least one processor. As the instructions are executed, the processor tracks a sampling action of a specimen provider using images of the specimen provider handling a specimen sampling kit. The processor also verifies whether or not the specimen provider is the same person as a person who has requested the specimen sampling kit, by using at least one of the imaged used for the tracking.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G06V 40/20 - Movements or behaviour, e.g. gesture recognition
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
According to an embodiment, a closure of a liquid sample storage container, attached to an upper opening of a storage container having a chamber for storing a liquid sample, may comprise a coupling member coupled to an upper portion of the storage container and a blocking member blocking the upper opening of the storage container. The coupling member may include a first body part, a second body part, and a closure part. The blocking member may include a side part interposed between the storage container and the second body part, and a pierceable blocking part connected to a lower portion of the side part, prepared to have elastic restorative force, and permitting entry of a pipette while keeping the upper opening of the chamber closed while not entered by the pipette. A first fixing part may be formed to fix the side part of the blocking member.
Disclosed herein is a method for detecting SARS-CoV-2 mutations in a sample comprising a nucleic acid molecule. By the method, rapid detection can be made of SARS-CoV-2 variants that has changed in viral characteristics (e.g., infectivity, mortality, vaccine effect, therapeutic effect, etc.), thus early preventing and promptly coping with the spread of infection of SARS-CoV-2 variants.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
55.
SWAB DEVICES FOR COLLECTING SPECIMENS AND METHODS FOR COLLECTING SPECIMENS USED TO DETECT RESPIRATORY PATHOGENS
The present invention relates to a swab device for collecting a specimen and a method for detecting a respiratory pathogen. The present invention can easily and accurately collect nostril and/or oral swab specimens from specimen collection sites (specifically, nostrils and/or oral cavity), can collect sufficient amounts of specimens to detect respiratory pathogens, can be used in self-sampling by ordinary persons as non-experts as well as sampling by experts, and can detect respiratory pathogens from the collected nostril and oral swab specimens, by reducing, to a particular length, the total length of the swab device for collecting a specimen or adopting, to a particular value, the ratio of the sum of the lengths of a head part and a supporting part to the length of a gripping part, which constitute the swab device for collecting a specimen.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12N 1/04 - Preserving or maintaining viable microorganisms
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
The disclosure relates to an optical signal detection device for analyzing a sample, which may precisely detect an optical signal by reducing noise caused as excitation light reflected by a blocking unit reaches a detector, wherein the blocking unit comprises a noise-reducing structure for adjusting a reflection angle of reflected light of the excitation light traveling along the second light path which is directed from a beam splitter to the blocking unit.
A movable diagnosis structure according to one implemented embodiment comprises: a housing having a space therein; a partition module for partitioning the space to include a preparation room and an analysis room; an inlet module providing an inlet path for a raw sample from the outside to the preparation room; and a transfer module providing a transfer path from the preparation room to the analysis room for a prepared sample which is the result of a preparation process of the raw sample in the preparation room. In the movable diagnosis structure, a process is performed to mix the prepared sample with an isothermal amplification reagent for detecting a target nucleic acid or a fast polymerase chain reaction (PCR) reagent for detecting the target nucleic acid, and then a nucleic acid amplification process is performed for the mixed product.
A61G 10/02 - Treatment rooms for medical purposes with means to maintain a desired pressure, e.g. for germ-free rooms
E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport
E04B 1/348 - Structures composed of units comprising at least considerable parts of two sides of a room, e.g. box-like or cell-like units closed or in skeleton form
B60P 3/14 - Vehicles adapted to transport, to carry or to comprise special loads or objects the object being a workshop for servicing, for maintenance, or for carrying workmen during work
E04H 1/12 - Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
E04H 3/08 - Hospitals, infirmaries, or the like; Schools; Prisons
F24F 9/00 - Use of air currents for screening, e.g. air curtains
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
According to an embodiment, a mobile diagnostic structure comprises a housing including a space therein; a partitioning module partitioning the space to include a preparation room and an analysis room; an inlet module providing an incoming path from an outside to the preparation room for a raw sample; and a transfer module providing a transfer path from the preparation room to the analysis room, for a pre-treated sample which is a result of pre-treating the raw sample in the preparation room.
A61G 10/02 - Treatment rooms for medical purposes with means to maintain a desired pressure, e.g. for germ-free rooms
E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport
E04B 1/348 - Structures composed of units comprising at least considerable parts of two sides of a room, e.g. box-like or cell-like units closed or in skeleton form
B60P 3/14 - Vehicles adapted to transport, to carry or to comprise special loads or objects the object being a workshop for servicing, for maintenance, or for carrying workmen during work
E04H 1/12 - Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
E04H 3/08 - Hospitals, infirmaries, or the like; Schools; Prisons
F24F 9/00 - Use of air currents for screening, e.g. air curtains
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
59.
SOLUTION DISPENSER DEVICE AND CONTROL METHOD IN SAMPLE PROCESSING SYSTEM
According to the disclosure, a solution dispenser in a sample processing system may comprise an air passage portion communicating with a liquid transport means transporting a solution, a first pump and a second pump connected in parallel with each other through the air passage and having different pumping capacities, each pump including a chamber, an air pressurizer linearly reciprocating in the chamber, and a driver connected to the air pressurizer to allow the air pressurizer to reciprocate in the chamber, and a controller controlling the driver to generate a positive pressure and negative pressure by each pump. It is possible to stably provide an accurate and precise pressure according to the pumping capacity of each pump without interference between pumps in a POC system adjusting the pressure of a liquid transport means using pumps having different pumping capacities.
SERVER FOR PREDICTING PREVALENCE OF INFECTIOUS DISEASE OF INTEREST IN TARGET AREA USING MOLECULAR DIAGNOSTIC TEST DATA, METHOD THEREFOR, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM THEREOF
The disclosure relates to a server for predicting the prevalence of an infectious disease of interest in a target area using molecular diagnostic test data, a method therefor, and a non-transitory computer-readable storage medium thereof, the server comprising: a communication unit for receiving, from a terminal or another server located in the target area, molecular diagnostic test data for a causative pathogen of the infectious disease of interest in the target area; and a processor for obtaining prevalence trend data of the infectious disease over time from the received molecular diagnostic test data for the target area, comparing the obtained prevalence trend data of the infectious disease with candidate epidemic curves of the infectious disease to select an epidemic curve with high similarity, and predicting the prevalence of the infectious disease of interest in the target area using the selected epidemic curve, wherein the candidate epidemic curves represent the historical prevalence of the infectious disease.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
61.
OPTICAL SPECTROMETRY-BASED METHOD AND DEVICE FOR DETECTING TARGET ANALYTE IN SAMPLE
Disclosed are an optical spectrometry-based method for detecting a target analyte in a sample and a device for detecting a target analyte in a sample using an optical spectrometer unit. Measurement is performed by effectively separating emission light from light measured by the spectrometer unit. A target nucleic acid is accurately detected, and the use of an optical filter for filtering a specific wavelength is not necessary.
The present invention relates to a computer-implemented method for preparing oligonucleotides used to detect a nucleotide mutation of interest in a target nucleic acid sequence. The present invention can provide oligonucleotides capable of detecting a nucleotide mutation on the basis of an integrated design rule, without the need to develop detailed design rules and modules considering the type of nucleotide mutation, the size of the mutation, whether a target to be detected is a wild-type and/or mutant sequence, sequence contents, and the like, by inputting information about a wild-type target nucleic acid sequence and a nucleotide mutation of interest, providing wild-type and mutant target nucleic acid sequences through the use of the input information, designing oligonucleotides for the mutant target nucleic acid sequence, and analyzing the matching between the designed oligonucleotides and the wild-type target nucleic acid sequence to select and provide oligonucleotides satisfying predetermined selection criteria.
G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Provided is a thermal module including a first thermal conductor to which a sample holder is to be thermally connected. The thermal module includes a first heating element thermally connected to the first thermal conductor and adapted to perform a heating operation to heating the sample holder. A themoelectric element is thermally connected to the first thermal conductor and adapted to perform a cooling operation to cool the sample holder.
Provided is a thermal cycler. A thermal module heats or cools one area of a sample holder containing a sample. A thermal pusher includes a pressure part for press-contacting the sample holder to the thermal module and a heating part heating an opposite area of the sample holder opposite to the one area. A slot space is defined between the thermal module and the thermal pusher, and is capable of positioning one or more sample holders therein.
SERVER AND METHOD FOR PREDICTING INFECTION RISK LEVEL OF PATHOGEN IN TARGET AREA USING MOLECULAR DIAGNOSTIC TEST DATA, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM
The disclosure relates to a server for predicting the infection risk level of pathogen in a target area using molecular diagnostic test data, a method therefor, and a non-transitory computer-readable storage medium thereof.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A community service management method, device and terminal are provided. According to an embodiment, a community service management method, device, and terminal may determine an activity level of a community service based on messages input to the community service accessed by a plurality of terminals, when the activity level of the community service is a threshold or less, select a recommended topic to be presented to the community service based on the main topic, and recommend a recommended topic based on the main topic of the community service.
The disclosure provides a solution mixing device including an electromagnet module including an accommodating portion in which a solution containing magnetic beads is positioned and a plurality of electromagnets arranged with the regard to the accommodating portion and a controller controlling magnetic forces of the plurality of electromagnets to move the magnetic beads and a solution mixing method. According to the disclosure, it is possible to uniformly mix the solution and to prevent leakage of the solution during the mixing process.
The disclosure relates to a server for providing a risk level alarm using molecular diagnostic test data, a method therefor, and a non-transitory computer-readable storage medium thereof. The server comprises a communication unit receiving molecular diagnostic test data, for a pathogen, for a first area from a terminal or a server located in the first area and a processor determining a pathogen infection risk level for the first area from the molecular diagnostic test data for the first area and determining a second area to which the pathogen is expected to spread according to the pathogen infection risk level for the first area, wherein the communication unit provides a distinct alarm according to the pathogen infection risk level for the first area to a terminal or server located in the determined second area.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
The disclosure relates to a nucleic acid reaction chamber. There is provided a nucleic acid reaction chamber including a body portion comprising a flow path and a sample region, wherein the flow path includes a first flow path and a second flow path, wherein the sample region is individually connected to lower portions of the first flow path and the second flow path, wherein the first flow path and the second flow path communicate with the outside, respectively. According to the disclosure, in spite of the small volume of the sample solution and the viscosity of the reaction mixture, the mixing of the sample solution and the reaction mixture may be uniformly performed, and the reliability of the detection result may be improved.
An optical signal detection device according to the present disclosure independently secures an excitation light path for each sample area by forming a plurality of blocking units in the excitation light path irradiated from a light source unit, thereby preventing interference between excitation lights, and blocks light from the outside and prevents noise other than the emission light by including light blocking housing for accurately detecting the emission light emitting from the sample to which the excitation light is irradiated, thereby double blocking a light irradiating area and a light emitting area.
Disclosed herein is a method for a positive control reaction using a pre-positive control composition. Unlike conventional positive controls, the pre-positive control composition according to the present disclosure is provided in the pre-positive control composition form, but not in a complete positive control form, until an experiment preparation stage, and can produce a complete-positive control through a positive control reaction, whereby the contamination that could occur in an experiment preparation stage for positive control preparation and positive control reactions can be minimize and an examination can be made to see whether the contamination comes from the positive control or not.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
72.
COMPUTER-IMPLEMENTED METHOD FOR PROVIDING NUCLEIC ACID SEQUENCE DATA SET FOR DESIGN OF OLIGONUCLEOTIDE
The present invention relates to a computer-implemented method for providing a nucleic acid sequence data set for the design of an oligonucleotide used to detect a target nucleic acid molecule of an organism of interest. In the present invention, nucleic acid sequence data retrieved by synonyms for a target nucleic acid molecule are sorted according to the taxonomic name and/or taxonomic identification (ID); taxonomic representative sequences are selected among nucleic acid sequence data having the same taxonomic name and/or taxonomic ID; and the selected taxonomic representative sequences are grouped according to the homology to select a group representative sequence in each group; and then nucleic acid sequence data having a homology of a predetermined value or more with the group representative sequence are provided. As a result, it was confirmed that multiple target nucleic acid sequences for the target nucleic acid molecule were retrieved without omission and the alignment results of the retrieved multiple target nucleic acid sequences were properly formed so as to be referred to in the design of oligonucleotides.
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
73.
SERVER FOR MANAGING CHAT ROOM, METHOD THEREFOR AND COMPUTER RECORDABLE MEDIUM STORING COMPUTER PROGRAM FOR PERFORMING SUCH A METHOD
Provided is a server for managing a chat room including a topic extractor for extracting a plurality of topics from a chat message displayed in a parent chat room, a major-minor topic classifier for classifying each of the plurality of the topics into a major topic or a minor topic, and a task performer for generating a child chat room in which a chat message corresponding to the minor topic is displayed.
Provided a thermal cycler including a thermal block housing comprising a thermal block accommodating a reaction vessel and a temperature control portion for controlling a temperature of the thermal block, a support frame provided at the lower side of the thermal block housing, and at least one damping module comprising a fastening member coupled to the thermal block housing and the support frame and an elastic member provided between the thermal block housing and the support frame and elastically supporting the thermal block housing while spaced apart from the support frame.
There is provided a cartridge for processing a sample, including a plurality of chambers, wherein one of the plurality of chambers is a sample chamber including an internal space physically divided into a sample space for receiving the sample and a dump space for collecting waste. The cartridge may secure a dump space with a sufficient volume within a limited cartridge space and may prevent leakage of a sample or waste and resultant contamination.
There are provided a liquid transport device and a sample processing cartridge including the same. There is provided a liquid transport device, comprising a container including a receiving space having a top opening and receiving a solution, and a nozzle part at a lower side thereof and a cap coupled to the top opening of the receiving space and including an air hole communicating with the receiving space and a shielding part preventing the solution from entering the air hole. The liquid transport device includes the shielding part that prevents the received solution from leaking out to the pressure control means, thereby preventing contamination of the sample processing device due to the movement of the solution during solution processing.
The present invention relates to sampling kits and methods for detecting respiratory pathogens, and has advantages of showing a positive rate equivalent to that in a conventional detection method using nasopharyngeal swabs; and allowing self-sampling.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
In a device according to the present disclosure, a light detection assembly including a light source module and a detection module is movable toward a sample holder. Since the vertically movable light detection assembly can be precisely aligned toward the sample holder, light may be accurately provided without distortion of the excitation light path irradiated to the sample.
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
Disclosed herein is a method for providing a preparation for detecting a target nucleic acid sequence in a specimen. According to an embodiment, conventional nucleic acid extraction processes performed in many steps can be omitted, whereby the shortage of nucleic acid extraction reagents can be solved and a preparation for detecting target nucleic acid sequence in a specimen can be supplied in an inexpensive and simple manner.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
80.
COMPUTER-IMPLEMENTED METHOD FOR PROVIDING COVERAGE OF OLIGONUCLEOTIDE SET FOR PLURALITY OF NUCLEIC ACID SEQUENCES
The present invention relates to a computer-implemented method for providing a coverage of an oligonucleotide set for a plurality of nucleic acids. The present invention provides nucleic acid sequences with the generation of probe-hybridized amplicons and/or nucleic acid sequences without the generation of probe-hybridized amplicons, by a combination of oligonucleotides according to match or mismatch information and position information of a forward primer, a probe, and a reverse primer included in an oligonucleotide set, and thus can provide a coverage of the oligonucleotide set for a plurality of nucleic acid sequences, can analyze specificity of the oligonucleotide set, and can modify the sequences of the oligonucleotides included in the oligonucleotide set for the improvement in specificity. According to the present invention, the specificity analysis results can be compared between an oligonucleotide set of an existing product and an oligonucleotide set of a new product, and the specificity change of the oligonucleotide set can be easily monitored.
The disclosure relates to an optical signal detection device. According to the disclosure, a device includes a sample holder configured to receive a plurality of samples, a light source module radiating excitation light to a plurality of sample areas on the sample holder, a detection module configured to detect emission light, and an excitation light filter module and an emission light filter module each including a dual bandpass filter unit. The device of the disclosure may detect more optical labels than the number of excitation light filter units included in the excitation light filter module using a dual bandpass filter unit. In particular, it is possible to perform detection using the dual bandpass filter which is used for both the excitation light filter module and the emission light filter module without moving the light source by adjusting the wavelength range of light which is transmitted through the dual bandpass filter.
The present invention relates to a specimen transport kit for detecting respiratory pathogens, which is configured to collect both a nasopharyngeal cavity specimen and a salivary specimen in a swab method and make a specimen transport medium impregnated with the specimens together, and a method for detecting respiratory pathogens using same. The present invention provides a higher positive rate and more accurate diagnostic results for respiratory pathogens than when the nasopharyngeal cavity specimen or the salivary specimen is used separately.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61B 5/08 - Measuring devices for evaluating the respiratory organs
83.
AUTOMATED ANALYSIS SYSTEM, METHOD AND STORAGE MEDIA
Embodiments of the disclosure relate to an automated analysis system, method, and a storage medium capable of automating sample preparation and sample analysis by operatively connecting a sample preparation device for preparing an analysis sample for biological analysis and a sample analysis device for performing analysis.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
An embodiment provides an optical signal detection device including a sample holder configured to accommodate a plurality of samples, a light source module including a plurality of light source units dedicated to each sample area to irradiate light to a plurality of sample areas on the sample holder, a filter module including a plurality of movable moving units for filtering light from the light source unit and a detection module configured to detect emission light of the sample.
METHOD FOR MANAGING RESPIRATORY INFECTIONS THROUGH MOBILE TERMINAL MANAGEMENT SYSTEM INCLUDING CENTRAL MANAGEMENT SERVER, SERVER, AND COMPUTER READABLE STORAGE MEDIUM
The present invention relates to a method for managing respiratory infections, a server, and a computer readable storage medium which conducts a respiratory infection test to a client who wants to the respiratory infection tests, receives the client's location information, and provides respiratory infection management information generated using the test result of the respiratory infection and client's location information for other clients so that it may minimize the spread of infection and efficiently quarantine against the respiratory infections while maintaining social and economic activities of the public.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
H04W 4/02 - Services making use of location information
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
86.
SAMPLING KIT USED IN DETERMINATION OF RESPIRATORY INFECTION
Disclosed is a sampling kit for determining respiratory infection, the kit including: a first vessel containing a washing-out solution; and a second vessel containing a transport medium containing a deactivating agent, so that sampling corresponding to a pre-analytical stage in a protocol for determination of the presence or absence of respiratory infection pathogens can be attained easily, safely, and stably, and self-sampling of a respiratory infection pathogen can be attained.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
The present invention relates to a cartridge for processing a sample, including a movable solution shuttle and, more specifically, to a cartridge comprising a body including a plurality of extraction chambers linearly disposed in a lengthwise direction and at least one solution shuttle configured to be movable between the plurality of extraction chambers and a sample processing device including a station for receiving the cartridge and a moving module for moving the cartridge. Since the cartridge and device of the present invention may contain all reagents required for sample processing in the cartridge, it has a simple structure and may automatically perform sample processing required for an assay in a single cartridge.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
88.
METHODS FOR PREPARING AN OPTIMAL COMBINATION OF OLIGONUCLEOTIDE SETS
The present invention relates to technologies for preparing an optimal combination of oligonucleotide sets used to simultaneously detect a plurality of target nucleic acid molecules. Unlike a conventional method of checking whether a dimer is formed in all candidate combinations of oligonucleotide sets, the present invention is capable of providing a combination of oligonucleotide sets used to detect a plurality of target nucleic acid molecules with speed and accuracy, by replacing only an oligonucleotide set with dimer formation in a first reference combination of oligonucleotide sets to provide, as a new reference combination, a combination with a reduction in dimer formation compared with the first reference combination, and replacing only an oligonucleotide set with dimer formation in the new reference combination to provide a combination with all dimers removed.
A sample holder transferring apparatus used in a thermal cycler of the present disclosure is provided that includes a sample holder housing in which a sample holder accommodating a sample or a sample reaction vessel is accommodated, a slide member, on which the sample holder housing is mounted, linearly moving in a sliding manner along a linear motion (LM) guide, a plurality of LM guides for providing a path allowing the sample holder housing to move linearly, a connecting member connecting the slide member to a driving assembly, and the driving assembly.
The disclosure relates to a computer-implemented method, system, and storage medium for collaborative development of a reagent for detection of the target nucleic acid. According to the disclosure, the method, system, and storage medium automatically match the developer and technology provider suitable for the characteristics of collaborative development in response to a request for collaborative development, thereby increasing the efficiency of collaborative development.
The disclosure relates to a method for detecting a target nucleic acid in a sample using a nucleic acid reaction detection device comprising a plurality of reaction areas independent from each other. According to the disclosure, the method may simultaneously perform two or more nucleic acid reactions which are carried out with different protocols and independently measure emitted optical signals, thereby detecting the target nucleic acid.
Embodiments of the disclosure relate to a device and method for detecting light in a plurality of independent reaction regions. According to the disclosure, a light detection device includes a plurality of thermally independent reaction regions, a movable optical module for irradiating the reaction regions with lights of a plurality of wavelengths, detectors for detecting lights emitted from the reaction regions, and a controller controlling the reaction regions, the optical module, and the detectors.
G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
G01N 21/74 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using flameless atomising, e.g. graphite furnaces
Provided a thermal cycler. In a case in which plurality of heat sinks participate in thermal control of a plurality of thermally independent sample holders for reliable nucleic acid reactions of the plurality of sample holder, a barrier is present between the adjacent heat sinks.
The present disclosure relates to a light module comprising a plurality of light sources emitting light to excite samples; a light source wheel accommodating the plurality of light sources; a plurality of filters filtering light emitted by the light sources; a filter wheel accommodating the plurality of filters; and a motor rotating the light source wheel and the filter wheel.
The present invention relates to technologies for determining a designable region of oligonucleotides in a plurality of target nucleic acid sequences having sequence similarity. In determining a conservative region in a plurality of nucleic acid sequences, unlike the conventional methods which is an empirical and manually selected methods, the present invention provides a more logical and efficient method by adopting a strategy of generating oligonucleotide sticks having sequence information about non-conservative positions within a predetermined allowable number or a minimum number of sequence patterns within a predetermined allowable number of sequence patterns while having a predetermined length or more from the alignment results of a plurality of target nucleic acid sequences and has excellent speed and accuracy.
The present invention relates to the detection of a target analyte in a sample using an S-shaped function for a slope data set. The method of the present invention comprises obtaining a first data set representing a growth curve by an amplification reaction for the target analyte; wherein said first data set includes a plurality of data points, each having a cycle number and a signal value at the cycle number; calculating a slope value at each cycle number for the first data set to obtain a second data set; wherein said second data set includes a plurality of data points, each having a cycle number and a slope value at the cycle number; calculating an S-shaped function that approximates a selected portion of the second data set; and using the S-shaped function to detect the target analyte in a sample.
The present disclosure relates to a thermal block for performing a plurality of reactions. In the thermal block, a plurality of sample wells are regularly arranged, and non-sample holes smaller than the sample wells are provided. Two or more non-sample holes are provided in a unit area defined by connecting central points of four adjacent sample wells among the plurality of sample wells in the thermal block. The thermal block prevents an error in which a reaction vessel may be erroneously fitted while minimizing the amount of thermal energy necessary to change the temperature thereof. The thermal block has superior durability to conventional thermal blocks.
The present invention relates to a method for detecting a nucleic acid of a gut microorganism in a sample using a nucleic acid of a bacterium as an internal control nucleic acid selected from a normal gut flora, and to a composition for nucleic acid amplification used in the method. The internal control according to the present invention is present in the sample from the beginning, and thus there is no inconvenience of separately adding an internal control after the sample collection process, and may be used as an internal control for the sample collection process, an internal control for the nucleic acid extraction process, and an internal control for the nucleic acid amplification process. In addition, the presence or absence of the nucleic acid of the gut microorganism in the sample may be detected with a high accuracy through the minimization of false-negative and false-positive determinations by using the nucleic acid of the bacterium as the internal control selected from the normal gut flora.
The present invention provides a method for providing a target nucleic acid sequence data set of a target nucleic acid molecule. The larger number of synonyms are retrieved from reliable sources than that of synonyms extracted by user experience. Thus, the target nucleic acid sequence data group of the target nucleic acid molecule retrieved based on the larger number of synonyms may cover various variant sequences of the target nucleic acid molecule.
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