Abstract

Described are systems, devices, and methods for providing interactive and tactile projections of sound and light in a bio-haptic security system.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G16H 30/00 - ICT specially adapted for the handling or processing of medical images

Abstract

Process for treating metal such as aluminum and its alloys to prevent corrosion which comprises coating the metal with a chromium-free conversion composition containing effective amounts of metal fluorozirconates and carboxylic metal salts. The process comprises coating the metal with a chromium-free conversion coating containing from about 4 to 8 grams of a metal fluorozirconate per liter of the chromium-free conversion coating and from about 0.5 to 5.0 grams of at least one carboxylic metal salt per liter of the chromium-free conversion coating. The incorporation of corrosion inhibitor salts with at least one carboxylate anion and a variety of cations in conversion coatings for aluminum and aluminum alloys to enhance corrosion performance and paint adhesion.

IPC Classes  ?

• C08K 5/096 -
• C09D 5/08 - Anti-corrosive paints
• C09D 7/63 - Additives non-macromolecular organic

Abstract

Vaccines directed to the SARS-CoV-2 antigen, methods of administering and/or treating a subject (including prophylactic treatment) infected and/or at risk of being infected with SARS-CoV-2. A transdermal membrane comprising a non-infectious icosahedral phage vaccine displaying a SARS-CoV-2 antigen is described wherein the membrane is stable at room temperature for greater than 3 months and uses thereof to vaccinate a subject against the SARS-CoV-2 antigen.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/14 - Antivirals for RNA viruses
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 15/73 - Expression systems using phage lambda regulatory sequences
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A filtration mask protects the wearer against airborne hazards. The mask is reusable and may be used in a number of configurations. The mask includes filters located to the side and beneath the line of sight of the wearer. The filters may be tailored to the use and type of environmental hazard.

IPC Classes  ?

• A61M 16/06 - Respiratory or anaesthetic masks
• A61M 16/10 - Preparation of respiratory gases or vapours
• A62B 23/02 - Filters for breathing-protection purposes for respirators
• A62B 18/00 - Breathing masks or helmets, e.g. affording protection against chemical agents or for use at high altitudes
• A62B 18/02 - Masks
• A62B 7/10 - Respiratory apparatus with filter elements
• A62B 18/10 - Valves
• A41D 13/11 - Protective face masks, e.g. for surgical use, or for use in foul atmospheres

Abstract

A medical ventilator for delivering a flow oxygen-containing gas to the airway of a patient, which comprises an oxygen containing gas source, a controlled valve arrangement for intermittent feeding of breathing gas from the gas source and expandable pressure chamber for to achieve desired tidal volume.

IPC Classes  ?

• A61M 16/20 - Valves specially adapted to medical respiratory devices
• A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases

Abstract

Antigen binding proteins that interact with class 5 ETEC adhesins, compositions comprising said antigen binding proteins, and methods of preventing or treating ETEC related disorders in a subject in need thereof comprising administering to said subject a therapeutically effective amount of one or more of said compositions are described.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• A61P 31/04 - Antibacterial agents
• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria

Abstract

The invention relates to a method of preventing, ameliorating or treating disease caused by coronavirus in a subject in need thereof comprising administering to the subject an immunogenic composition comprising a therapeutically effective amount of one or more bacteriophage displaying on its capsid one or more antigenic coronavirus peptides fused with one or more bacteriophage capsid proteins (PVPs).

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• A61K 39/12 - Viral antigens

Abstract

This invention is directed to a process of coating metal in a trivalent chromium conversion-electrolyte coating wherein the metal anode or cathode is subjected to a current density ranging up to about 3.0 amperes per square foot for a period ranging up to 60 minutes.

IPC Classes  ?

• C25D 3/06 - Electroplating; Baths therefor from solutions of chromium from solutions of trivalent chromium
• C25D 3/10 - Electroplating; Baths therefor from solutions of chromium characterised by the organic bath constituents used
• C25D 3/66 - Electroplating; Baths therefor from melts

Abstract

The present disclosure describes methods and systems for predicting if a subject has an increased risk of having or developing venous thromboembolism, including prior to the detection of symptoms thereof and/or prior to onset of any detectable symptoms thereof. The present disclosure also describes a method of generating a model for predicting venous thromboembolism.

IPC Classes  ?

• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
• G06N 20/00 - Machine learning

Abstract

Invention relates to corrosion-inhibiting compositions and the process of using said compositions to protect metal from corrosion. The compositions comprise of sulfonates, a carboxylic-sulfonic acid metal complex, antioxidants, fluorinated copolymers, hydrophobic silanes and siloxane additives and solvent.

IPC Classes  ?

• C09D 5/08 - Anti-corrosive paints
• C23F 11/14 - Nitrogen-containing compounds
• C23F 11/16 - Sulfur-containing compounds
• C23F 11/173 - Macromolecular compounds

Abstract

Methods, primers, and kits for detecting Anaplasma phagocytophilum (A. phagocytophilum ) by amplification of a multi-copy DNA target sequence found within the msp2 gene of A. phagocytophilum are disclosed. Methods for treating A. phagocytophilum infections, including tick-borne fever and human granulocytic anaplasmosis are also disclosed.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A temporary aortic occlusion device is disclosed, having an expandable locator portion and an expandable occlusion portion. The expandable locator portion assists a user in determining whether the distal end of the device has been advanced within a patient's aorta, and the occlusion portion is expanded to occlude the patient's aorta, preferably below the renal arteries.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 17/08 - Wound clamps
• A61K 9/70 - Web, sheet or filament bases
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/10 - Balloon catheters
• A61M 29/02 - Inflatable dilators; Dilators made of swellable materials

Abstract

The invention comprises synergistic compositions of at least one metal polycarboxylate and lithium phosphate. The synergistic compositions are designed to be added to film-forming or other compositions to reduce the corrosion of various metal surfaces or substrates on which the synergistic compositions are applied.

IPC Classes  ?

• C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
• C09D 175/04 - Polyurethanes
• C09D 179/08 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

Abstract

Composition and process for preparing corrosion-resistant passive coatings on bulk-aluminum alloys and aluminum powder-pigments; said coatings derived from an acidic aqueous composition consisting essentially of potassium hexafluorozirconate, basic chromium sulfate and potassium tetrafluoroborate.

IPC Classes  ?

• C09D 5/10 - Anti-corrosive paints containing metal dust

Abstract

The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including an isolated polypeptide comprising an enzymatically active domain (EAD) of a Bacillus bacteriophage endolysin.

IPC Classes  ?

• A23L 29/00 - Foods or foodstuffs containing additives; Preparation or treatment thereof
• A61K 38/16 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses

Abstract

The subject matter of the instant invention relates to a dental implant surgical apparatus and system comprising a customized dental ridge augmentation matrix and one or, optionally, a plurality of dental implant surgical drill guides, and methods of use thereof.

IPC Classes  ?

• A61B 17/17 - Guides for drills
• A61C 3/04 - Supports for holding tooth drills in order of use
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
• A61C 13/00 - Dental prostheses; Making same
• A61C 13/12 - Tools for fastening artificial teeth; Holders, clamps, or stands for artificial teeth
• A61F 2/28 - Bones

Abstract

A method for the prevention of the onset of pulmonary oxygen toxicity and/or reduction of decrements of pulmonary function due to pulmonary oxygen toxicity comprising administration of a prophylactically effective amount of an anticholinergic, optionally together with a pharmaceutically acceptable excipient.

IPC Classes  ?

• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 31/38 - Heterocyclic compounds having sulfur as a ring hetero atom
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/46 - 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine

Abstract

The aluminum anode alloy consists essentially of an aluminum base and effective amounts of tin and indium. The aluminum alloy is useful as a sacrificial metallic coating, as a protective aluminum anode, and as a pigment in polymeric coatings.

IPC Classes  ?

• B32B 15/01 - Layered products essentially comprising metal all layers being exclusively metallic
• B32B 15/20 - Layered products essentially comprising metal comprising aluminium or copper
• B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
• C09D 5/10 - Anti-corrosive paints containing metal dust
• C22C 21/00 - Alloys based on aluminium
• C23F 13/14 - Material for sacrificial anodes

Abstract

The subject matter of the instant invention relates to methods of enhancing harvesting of phages against a targeted host bacteria, as well as methods of identifying phages likely to have an enhanced propensity to infect and kill an infectious pathogenic bacteria in vivo, from samples comprising phages. The invention also relates to phage libraries, pharmaceutical compositions, methods of treatment, and phage-based diagnostic methods and methods of detecting bacteria related thereto.

IPC Classes  ?

• A61K 35/76 - Viruses; Subviral particles; Bacteriophages
• C12N 1/20 - Bacteria; Culture media therefor
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

A capacitor having first and second electrodes and a scaffold dielectric. The scaffold dielectric comprises an insulating material with a plurality of longitudinal channels extending across the dielectric and filled with a liquid comprising cations and anions. The plurality of longitudinal channels are substantially parallel and the liquid within the longitudinal channels generally has an ionic strength of at least 0.1. Capacitance results from the migrations of positive and negative ions in the confined liquid in response to an applied electric field. A method of supplying power to a load using the capacitor and a method of making the capacitor is additionally disclosed.

IPC Classes  ?

• H01G 11/62 - Liquid electrolytes characterised by the solute, e.g. salts, anions or cations therein
• H01G 4/04 - Liquid dielectrics

Abstract

Methods of detecting actively growing host organisms, including bacterial organisms, involving the detection of ribonucleic acid (RNA) products produced by unmodified infectious bioagenis that infect the host organisms are provided. Related methods of assessing drug susceptibility and resistance are further provided. In addition to these surrogate detection methods, related reaction mixtures, kits, systems, and microfluidic cards are also provided.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

A radiograph stand allowing weight placed on an injured leg/foot be measured and recorded while taking a weight-bearing radiograph, A method for taking weight bearing radiograph of a patient's foot, ankle, leg. knee, thigh, hip, pelvis, and spine.

IPC Classes  ?

• A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

Abstract

The invention comprises synergistic compositions of at least two metal carboxylates as corrosion inhibitors based on polycarboxylate anions and a variety of different cations. The inhibitors are designed to be added to film forming or other compositions to reduce the corrosion of the metal substrate on which the synergistic compositions are applied.

IPC Classes  ?

• C09D 5/08 - Anti-corrosive paints
• C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
• C09D 175/04 - Polyurethanes
• C09D 179/08 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
• C10M 105/26 - Carboxylic acids or their salts having more than one carboxyl group bound to an acyclic carbon atom or cycloaliphatic carbon atom
• C23F 11/173 - Macromolecular compounds

Abstract

The invention relates to methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also contemplated herein.

IPC Classes  ?

• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
• A61L 15/44 - Medicaments
• A61P 31/04 - Antibacterial agents
• A61P 31/10 - Antimycotics
• C07K 7/04 - Linear peptides containing only normal peptide links
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

Compositions including a fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to anemic conditions, are provided, including compositions and methods for treating anemic conditions such as hemolytic anemia and anemia of chronic disease, and other related conditions.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
• A61P 7/06 - Antianaemics

Abstract

Compositions including an fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to inflammation and conditions related to inflammation, including anemia of chronic disease, insulin resistance, metabolic syndrome, autoimmune disease, hypertension, diabetes, nonalcoholic fatty liver disease, cardiovascular disease, cancer, aging, neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, and other related conditions, and other related conditions.

IPC Classes  ?

• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 5/50 - Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
• A61P 7/06 - Antianaemics
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The subject matter of the instant invention relates to methods of compounding compositions comprising bacteriophage effective for treating bacterial infections, including but not limited to, multidrug resistant bacterial infections. The invention also relates to compositions, bacterial diversity sets, and phage libraries prepared according to the methods of the instant invention.

IPC Classes  ?

• A61K 35/76 - Viruses; Subviral particles; Bacteriophages
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The invention relates to compositions comprising one or more insecticides and further comprising a carrier composition comprising one or more glycols, and methods of controlling an insect population comprising applying said compositions to the insect habitat using a thermal fogger.

IPC Classes  ?

• A01P 7/00 - Arthropodicides
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

Provided are compositions and methods for promoting tolerance to auto-immune antigens. In general the compositions include quantum dots (QDs) that are in association with auto-immune peptide antigens. It is shown that QDs can be used to generate immunological tolerance by controlling the density of self-antigen on QDs. Peptide-QDs rapidly concentrate in draining lymph nodes, and co-localize with macrophages expressing scavenger receptors involved in tolerance. Treatment with peptide-QDs reduces disease incidence 10-fold. The degree of tolerance and the underlying expansion of regulatory T cells correlates with the density of myelin molecules presented on QDs such that higher numbers of tolerogenic particles displaying lower levels of self-peptide are more effective for inducing tolerance than fewer particles each displaying higher densities of peptide. The disclosure is therefore relevant to promoting tolerance to antigens that are involved in a variety of autoimmune disorders.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/107 - Emulsions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants

Abstract

This invention relates to non aqueous non-volatile alkylated siloxane compositions having low VOC and vapor pressure of about 31 millimeters of mercury at 20°C. consisting essentially of a mixture of a linear or open-chain methyl alkylated siloxane having two silicon atoms and a siloxane having three silicon atoms alkylated with methyl groups.

IPC Classes  ?

• C11D 7/50 - Solvents
• C11D 7/26 - Organic compounds containing oxygen

Abstract

The invention relates to methods of trapping a pest, said method comprising providing ferromagnetic particles for ingestion by the pest, and trapping the pest using one or more magnets, wherein a trapped pest has ingested and internally accumulated an amount of the ferromagnetic particles sufficient to permit immobilization of the pest using said one or more magnets. Devices for use with the methods of the instant invention are also disclosed.

IPC Classes  ?

• A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
• A01M 1/10 - Traps
• A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Abstract

This invention relates to galvanic aluminum alloy powder-pigments coated with semi-conducting corrosion-inhibiting compositions and particularly to the process for preparing said coated powder-pigments for coating substrates to inhibit corrosion. The coated aluminum alloy powder-pigments are electrically active and prevent corrosion of metals which are more cathodic (electropositive) than the coated-aluminum alloy pigments.

IPC Classes  ?

• C09K 3/00 - Materials not provided for elsewhere

Abstract

This invention relates to sacrificial-metal pigments coated with an effective amount of at least one metal oxide or a combination of metal oxides such as a mixture of chromium and zirconium oxides, and the process for preparing said coated pigments and combination thereof with film-forming binders for coating metal substrates to inhibit corrosion. The coated sacrificial-metal pigments are electrically active to prevent corrosion of metal substrates that are more cathodic (electropositive) than the metal oxide coated metal pigments.

IPC Classes  ?

• B01J 29/06 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
• B01J 37/02 - Impregnation, coating or precipitation
• C03C 17/10 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with metals by deposition from the liquid phase

Abstract

The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response against C. jejuni in a subject comprising one or more MeOPN-6-Gal monosaccharides, one or more MeQPN-4-Gal monosaccharides, and/or one or more MeOPN-2-Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs, and methods of inducing an immune response against C. jejuni in a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic constructs, to the subject. Methods of treating, preventing, or ameliorating a C. jejuni bacterial infection in a subject comprising administering to the subject one or more doses of immunoglobulins directed to one or more of the MeOPN moieties are also contemplated.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/02 - Bacterial antigens
• A61K 39/106 - Vibrio; Campylobacter
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61P 1/12 - Antidiarrhoeals
• A61P 37/04 - Immunostimulants

Abstract

The invention relates to a method for preventing, ameliorating or treating disease caused by dengue vims in a subject in need thereof comprising administering to the subject a dengue vaccine formulation in combination with a NS3 helicase polypeptide and/or fragment(s) thereof, wherein said method comprises stimulating humoral as well as cell- mediated immunity to the dengue virus in the subject,

IPC Classes  ?

• A61K 39/12 - Viral antigens
• C07K 1/00 - General processes for the preparation of peptides
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

Methods and systems for determining true time delay from each receiving element of an 'active electronically scanned array' (AESA) or a phased array antenna. Embodiments of the invention can include electromagnetic EM elements, optical waveguides, and wavelength selective FGBs are collectively configured as a plurality of dual purpose elements that couples an EM field and uses an induced voltage to change an index of refraction of the optical waveguide's electro-optic (EO) material, where the EO material will also function as a dielectric in an antenna element, where the signals comprising optical signals propagate through EM element acting as phase delay elements, where the measuring system compares the reflected signals with a reference signal with no phase delay to determine said signals phase delay.

IPC Classes  ?

• G01S 7/03 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group - Details of HF subsystems specially adapted therefor, e.g. common to transmitter and receiver
• G01S 13/42 - Simultaneous measurement of distance and other coordinates
• H01Q 3/00 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system

Abstract

An insecticide composition designed for improved autodissemination. The insecticide may be used as a dry powder or a wet composition. The composition allows for better transfer of active ingredient to the target species, as well as improved stability of the active ingredient.

IPC Classes  ?

• A01M 1/20 - Poisoning, narcotising, or burning insects
• A01N 25/14 - Powders or granules wettable
• A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents

Abstract

The present invention is a software, methods, and system for creating and editing a medical logistics simulation model and for presenting the simulation model simulated within a military or disaster relief scenario. A user interface that allows a user to enter and edit platforms and associated attributes for a simulation model. The system runs the simulation model based on user input and historical data stored in databases using the inventive software. The present invention provides an output for allowing a user to view casualty rates, patient streams, and medical requirements or any other desired aspect of the simulation model.

IPC Classes  ?

• G06Q 50/22 - Social work
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G06F 17/40 - Data acquisition and logging
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• G06Q 50/24 - Patient record management (processing of medical or biological data for scientific purposes G06F 19/00)

Abstract

An oleaginous corrosion-resistant lubricating composition comprising at least one alpha-olefin synthetic oil and effective amounts of metal salts of sulfonic acids/carboxylic acids, alkylated aromatic compounds as solubility modifiers, pour-point depressants, at least one antioxidant, and metal deactivators.

IPC Classes  ?

• C10M 169/04 - Mixtures of base-materials and additives

Abstract

The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C, jejuni) in a subject comprising one or more MeOPN⃗6 Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs and methods of inducing an immune response against C. jejuni in a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic construct, to the subject.

IPC Classes  ?

• A61P 37/04 - Immunostimulants
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 39/106 - Vibrio; Campylobacter

Abstract

An apparatus in a surrounding liquid and methods of using same. The apparatus includes an acoustic Fresnel zone plate comprising a compliant frame, a substrate connected to the frame, and an acoustic diffraction grating connected to the substrate. The acoustic diffraction grating includes a plurality of concentric rings or a plurality of concentric islands. The substrate is acoustic - impedance-mismatched with the acoustic diffraction grating. The acoustic Fresnel zone plate includes at least one acoustic focal spot. The substrate is acoustic-impedance-mismatched with the surrounding liquid and the acoustic diffraction grating is acoustic-impedance-matched with the surrounding liquid, or the substrate is acoustic-impedance-matched with the surrounding liquid and the acoustic diffraction grating is acoustic-impedanee-mismatehed with the surrounding liquid.

IPC Classes  ?

• G02B 3/08 - Simple or compound lenses with non-spherical faces with discontinuous faces, e.g. Fresnel lens

Abstract

The inventive subject matter relates to a construct comprising antigens derived from multiple enterobacteria including Campylobacter jejuni capsule polysaccharide polymer, enterotoxigenic Escherichia coli recombinant polypeptide construct and lipopolysaecharide from Shigella spp.. The subject invention also relates to a method of inducing an immune response utilizing the inventive composition.

IPC Classes  ?

• A61K 39/106 - Vibrio; Campylobacter

Abstract

This invention is directed to a portable lightweight, easy-carry, reusable, and self-contained assembly for sterilizing contaminated equipment using ozone and humidity generated in situ without requiring external electricity, fuels or other exogenous energy sources for operation and a method of use thereof.

IPC Classes  ?

• A61L 2/20 - Gaseous substances, e.g. vapours

Abstract

The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing and anti-C. jejuni immune response.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/02 - Bacterial antigens
• A61K 39/385 - Haptens or antigens, bound to carriers

Abstract

A surgical system is provided. The system includes a reference unit, an implant and a detector. The reference unit includes a first trackable element. The implant includes a second trackable element. The detector is configured to provide at least one signal corresponding to a detected location of at least one of the first trackable element and the second trackable element.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)

Abstract

Disclosed is a method of simulating mastication. The method includes obtaining computer-readable three-dimensional representations of a first skeletal fragment including a portion of at least one of a mandible and a maxilla and of a recipient skeletal fragment including a portion of at least one of a mandible and a maxilla. The method also includes obtaining placement data and obtaining muscle insertion data. The method also includes simulating a contraction of a muscle positioned according to the muscle insertion data in a representation of a surgical hybrid comprising at least a portion of the first skeletal fragment positioned according to the placement data relative to at least a portion of the recipient skeletal fragment. The method also includes outputting a representation of mastication represented by the simulating.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
• A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions

Abstract

A method for computer-assisted planning of a transplant surgery is provided. The method includes obtaining a computer-readable representation of a donor and recipient skeletal fragment; determining surgical cutting planes on the computer-readable representation of the donor skeletal fragment from which a portion of the donor skeletal fragment from the computer-readable representation of the donor skeletal fragment will be harvested; determining virtual cutting guides; performing a virtual osteotomy to separate the portion of the donor skeletal fragment from the computer-readable representation of the donor skeletal fragment from a remainder portion of the donor skeletal fragment based on a position of the virtual cutting guides that are attached to the computer-readable representation of the donor skeletal fragment; positioning the donor skeletal fragment within a transplant region of the recipient skeletal fragment; and creating a hybrid computer-readable representation comprising the recipient skeletal fragment and the portion of the donor skeletal.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• A61B 17/16 - Osteoclasts; Drills or chisels for bones; Trepans
• A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

A method of simulating 3 -degrees of freedom spacecraft rotational dynamics is provided that includes attaching a payload, using a spherical air bearing, to an inner gimbal of a 3- axis gimbal, where the 3 -axis gimbal includes an outer gimbal, a mid-gimbal and the inner gimbal, using a motion controller to control motion of each the gimbal of the 3 -axis gimbal, where the motion controller includes an appropriately programmed computer and a motion control motor, sensing limits of free travel of the spherical air bearing, using a position sensor, and changing a position of the 3 -axis gimbal away from the limit of free travel of the spherical air bearing when the spherical air bearing approaches the limit of free travel, wherein the position change effects travel of the spherical bearing to be unbounded by the limit of free travel, wherein 4π steradians spacecraft dynamics of the payload are simulated.

IPC Classes  ?

• G09B 9/12 - Motion systems for aircraft simulators
• G09B 9/52 - Simulators for teaching or training purposes for teaching control of vehicles or other craft for teaching control of an outer space vehicle
• A63G 31/16 - Amusement arrangements creating illusions of travel

Abstract

A splice kit is provided for repairing a cable (12) having a central conductor (22), an insulator (24) surrounding the central conductor, an outer conductive sheath (26) surrounding the insulator, and a jacket (28) surrounding the outer conductive sheath. The splice kit includes a central conductor joint (46) that is electrically conductive and is configured to engage the central conductor of the cable such that the central conductor joint defines a portion of an electrical path of the central conductor. The splice kit also includes a dielectric insert (48) configured to at least partially surround the central conductive joint and the central conductor of the cable, and an outer sheath joint (52) that is electrically conductive and is configured to at least partially surround the dielectric insert. The outer sheath joint is configured to be electrically connected to the outer conductive sheath of the cable such that the outer sheath joint defines a portion of an electrical path of the outer conductive sheath. The splice kit further includes a jacket joint (54) configured to at least partially surround the outer sheath joint and the jacket of the cable.

IPC Classes  ?

• H02G 1/16 - Methods or apparatus specially adapted for installing, maintaining, repairing, or dismantling electric cables or lines for repairing insulation or armouring of cables
• H02G 15/18 - Cable junctions protected by sleeves, e.g. for communication cable
• H02G 15/08 - Cable junctions
• H01R 9/05 - Connectors arranged to contact a plurality of the conductors of a multiconductor cable for coaxial cables
• H02G 1/14 - Methods or apparatus specially adapted for installing, maintaining, repairing, or dismantling electric cables or lines for joining or terminating cables

Abstract

The inventive method and associated reagents relate to a molecular approach to determining Campylobacter jejuni capsule/Penner types. The invention also relates to a method of identifying Campylobacter jejuni types using primers in a multiplex PCR assay.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

A time-domain inertial sensor comprising: a support structure having an electrode plane parallel to an x-y plane of an x-y-z mutually orthogonal coordinate system, wherein the support structure's largest dimension lies within the x-y plane; a proof mass having a first surface parallel to the x-y plane; wherein the proof mass is springedly coupled to the support structure such that the first surface is separated from the electrode plane by a gap; a driver configured to drive the proof mass to oscillate with respect to the support structure in approximately only the x-direction such that, while oscillating, the gap does not vary significantly; and a first, time-domain, proximity switch disposed to switch from an open state to a closed state each time the proof mass is in a first reference position with respect to the support structure.

IPC Classes  ?

• G01C 19/56 - Turn-sensitive devices using vibrating masses, e.g. vibratory angular rate sensors based on Coriolis forces

Abstract

High thermal conductivity materials and methods of their use for thermal management applications are provided. In some embodiments, a device comprises a heat generating unit (304) and a thermally conductive unit (306, 308, 310) in thermal communication with the heat generating unit (304) for conducting heat generated by the heat generating unit (304) away from the heat generating unit (304), the thermally conductive unit (306, 308, 310) comprising a thermally conductive compound, alloy or composite thereof. The thermally conductive compound may include Boron Arsenide, Boron Antimonide, Germanium Carbide and Beryllium Selenide.

IPC Classes  ?

• H01L 23/36 - Selection of materials, or shaping, to facilitate cooling or heating, e.g. heat sinks
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

The inventive subject matter relates to a recombinant polypeptide construct comprising enterotoxigenic Escherichia coli fimbrial subunits. The recombinant polypeptide constructs comprise multiple subunits to the same or different ETEC fimbrial types. The constructs are useful for inclusion in immunogenic formulations for the inductin of immunity against entertoxigenic Escherichia coli. The inventive subject matter also relates to the use of the recombinant polypeptide constructs in induce anti- enterotoxigenic Escherichia coli.

IPC Classes  ?

• C07K 14/24 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
• A61K 39/108 - Escherichia; Klebsiella

Abstract

This invention relates to galvanic aluminum alloy powder-pigments coated with semi-conducting corrosion inhibiting compositions and to the process for preparing said coated powder-pigments for coating metal substrates to inhibit corrosion. The coated aluminum alloy powder-pigments are electrically active and prevent corrosion of metals which are more cathodic (electropositive) than the coated aluminum alloy pigments.

IPC Classes  ?

• B05D 7/24 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
• B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
• C23C 22/00 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals

Abstract

A gyroscope comprising: a frame; a tuning fork comprising a base and first and second prongs, wherein the base has proximal and distal ends, and wherein the proximal end is coupled to the frame and the distal end is coupled to the first and second prongs; first and second drivers configured to drive the first and second prongs respectively to oscillate with respect to the frame in a first direction, such that the prongs oscillate at their respective resonant frequencies and 1800 out of phase with each other; and at least two digital position triggers operatively coupled to the frame and to the tuning fork, wherein each position trigger is configured to experience at least two trigger events during each oscillation of the tuning fork in a second direction, wherein the second direction is orthogonal to the first direction.

IPC Classes  ?

• G01C 19/5607 - Turn-sensitive devices using vibrating masses, e.g. vibratory angular rate sensors based on Coriolis forces using vibrating tuning forks

Abstract

Sacrificial-metal pigments are coated with an effective amount of at least one metal oxide or a combination of metal oxides such as a chromium-zirconium oxide, and the process for preparing said coated pigments and combination thereof with film-forming binders for coating metal substrates to inhibit corrosion. The coated sacrificial-metal pigments are electrically active to prevent corrosion of metal substrates that are more.

IPC Classes  ?

• C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
• C09K 13/06 - Etching, surface-brightening or pickling compositions containing an inorganic acid with organic material
• C23C 28/02 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and only coatings of metallic material
• H01B 1/02 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of metals or alloys

Abstract

A weapon mounting system for a vehicle, such as a helicopter. The weapon mounting system illustratively includes a weapon cradle supporting a machine gun for pivoting movement about a generally horizontal elevational axis. A carriage supports the weapon cradle and is supported by a pintle for rotation about a generally vertical azimuth axis. An ejection collection device is supported by the carriage and collects spent shell casings and links ejected from the machine gun for discharge through the pintle. A trigger assembly illustratively provides for manual operation by a gunner and for remote electrical operation by a pilot.

IPC Classes  ?

• F41A 9/55 - Fixed guiding means, mounted on, or near, the cartridge chamber
• B64D 7/06 - Arrangement of military equipment, e.g. armaments, armament accessories, or military shielding, in aircraft; Adaptations of armament mountings for aircraft the armaments being firearms movably mounted
• F41A 23/04 - Unipods

Abstract

An inertial device is disclosed. In one embodiment, the device comprises a support structure and first and second spring mass systems coupled to the support structure. The first spring mass system comprises first and second time domain digital triggers configured to measure rotation and displacement respectively of the support structure about a first axis and along an orthogonal second axis. The second spring mass system comprises third and fourth time domain digital triggers configured to measure acceleration and displacement respectively of the support structure about the second axis and along the first axis.

IPC Classes  ?

• G01C 19/5762 - Structural details or topology the devices having a single sensing mass the sensing mass being connected to a driving mass, e.g. driving frames

Abstract

A gyroscope comprising: a support structure: a drive mass springedly coupled to the support structure such that movement of the drive mass with respect to the support structure is substantially restricted to movement in a first direction; a driver configured to cause the drive mass to oscillate with respect to the support structure in the first direction; a sense mass springedty coupled to the drive mass such that movement of the sense mass with respect to the drive mass is substantially restricted to movement in a second direction, which is orthogonal to the first direction; and a digital trigger comprising a proximity switch coupled between the drive mass and the sense mass, wherein the switch is configured to switch from an open state to a closed state each time the sense mass is in a reference position with respect to the drive mass.

IPC Classes  ?

• G01C 19/5762 - Structural details or topology the devices having a single sensing mass the sensing mass being connected to a driving mass, e.g. driving frames

Abstract

Provided are methods of producing an immunogenic capsule polysaccharide polymer composition with improved structural integrity and immunogenic properties, and it's use to elicit an immune response to Campylobacter jejuni.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens

Abstract

Apparatus and methods for a resonator with reduced acceleration sensitivity and phase noise using a time domain switch. In one embodiment, the resonator comprises: a frame; a first oscillator configured to oscillate with respect to the frame; a first driver configured to drive the first oscillator at the first oscillator's resonant frequency; a first half of a first relative position switch mounted to the first oscillator; a second oscillator having substantially the same resonant frequency as the first oscillator, wherein the first and second oscillators are designed to respond in substantially the same manner to external perturbations to the frame; a second half of the first relative position switch mounted to the second oscillator; and wherein as the first oscillator oscillates there is relative motion between the first and second oscillators such that the first relative position switch passes through a closed state in each oscillation when the first and second switch halves pass by each other.

IPC Classes  ?

• H03B 5/30 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element being electromechanical resonator

Abstract

This Invention relates to galvanic aluminum alloy powder-figments coated with a semi-conducting corrosion inhibiting oxide ad the process for preparing said coated powder-pigments in combination with film-forming binders for coating metal substrates to inhibit corrosion. The coated aluminium alloy powder-pigments are electrically active aid prevent corrosion of metals which are more catholic (electropositive) than the aluminium alloy pigments;

IPC Classes  ?

• C09D 5/10 - Anti-corrosive paints containing metal dust

Abstract

A cushioning bandage with absorbent properties, configured to permit easy positioning over a wound. The bandage comprises a highly lofted lamb's wool pad attached to variable lengths of elastic material. The bandage is configured for easy application to patients.

IPC Classes  ?

• A61F 13/00 - Bandages or dressings; Absorbent pads

Abstract

An oscillatory apparatus and methods of utilizing the same. In one embodiment, the apparatus comprises a force sensor having a proof mass, with one or more sensing electron tunneling electrodes disposed thereon, and a frame comprising one or more reference electron tunneling electrodes. Conductive plates disposed on the sensor base and capping wafers induce oscillations of the proof mass. The sensing and the reference electrode pairs are disposed in a face-to-face configuration, thus forming a digital switch characterized by one or more closed states. In the closed state, the switch generates triggering events, thereby enabling the sensing apparatus to generate a digital output indicative of the mass position. The time period between consecutive trigger events is used to obtain mass deflection due to external forcing. Time separation between the triggering events is based on the physical dimensions established during fabrication, thus not requiring ongoing sensor calibration.

IPC Classes  ?

• H03L 7/00 - Automatic control of frequency or phase; Synchronisation

Abstract

A device for automatic monitoring intravenous fluid flow rate and temperature. The inventive device is capable of automatically adjusting the temperature of the fluid administered to a patient and recording the fluid flow rate and temperature. The device is also capable of transferring data to an electronic data storage repository via a wire connection or wirelessly.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

A method provides immediate, direct and controlled time release of an effective amount of therapeutics to a wound site for a prolonged period. The pharmaceutical formulation comprising a plurality of nanoparticles, said nanoparticles encapsulating a therapeutically effective amount of one or more antibacterial agents, and an application of the formulation to an implant before surgery provide for extended release of said antibacterial agents.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body
• A61K 9/50 - Microcapsules
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons

Abstract

Immunogenic compositions, and method of using the compositions to elicit an immune response against Campylobacter jejuni. The compositions are isolated polysaccharide polymers derived from Camplylobacter jejuni capsule.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A method and device to temporarily incapacitate a subject for a prolonged period by first applying to said subject a continuous pulsed electric waveform to incapacitate the subject, followed by applying a second intermittent pulsed electric waveform to the subject, which safely maintains the incapacitation of the subject with forced breathing.

IPC Classes  ?

• F41B 15/04 - Batons; Truncheons; Sticks; Shillelaghs with electric stunning-means

Abstract

The invention relates to antigens, associated with sterile immunity, and methods of their use, in an immunogenic formulation to confer an immune response against Plasmodium falciparum. The inventive antigens were identified by their association with sterile immunity against malaria.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• C07K 14/445 - Plasmodium

Abstract

A method for detection blood borne pathogen in whole blood, comprising collecting a blood sample from a subject, heating said sample for a period of time, adding said heated sample to a pre-mixed LAMP solution comprising one or more LAMP primer set, and Bst DNA polymerase to create a reaction mixture, incubating said reaction mixture for a period of time and determining the presence of blood born pathogen.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

This invention relates to non-volatile siloxane compositions having low VOC, a flash point above 140°F, and a vapor pressure of less than seven millimeters of mercury (7mm Hg). The non-volatile siloxane compositions consist essentially of specific amounts of alkylated cyclosiloxane have 5 or 6 repeating siloxane units, an alkylated cyclosiloxane having 3 or 4 repeating siloxane units, at least one alkylene glycol alkyl ether acetate and monohydric aliphatic alcohols.

IPC Classes  ?

• C11D 7/50 - Solvents
• C11D 7/26 - Organic compounds containing oxygen

Abstract

Provided is a transgenic animal model for testing immunogenicity and protective efficacy of human vaccines and the method for generating such a multitransgenic animal. Also disclosed are methods for screening compositions for human vaccine development. More specifically, a mouse model capable of expressing human leukocyte antigen DR4, and human costimulatory molecules (CD80) upon infusion of human HLA-matched hematopoietic stem cells, which can develop into a functional human immune system is provided.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• A01K 67/027 - New breeds of vertebrates
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Abstract

The disclosure relates to a reverse transcription loop-mediated isothermal amplification (LAMP) assay for the detection of dengue virus. The assay is capable of simultaneous detection of 1-4 serotypes of dengue virus in a single reaction. The disclosure also provides a set of primers including degenerate primers for the assay. The sequence regions of serotypes 1-4 for primer design are also illustrated.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

The inventive method and associated reagents relate to a molecular approach to determining Campylobacter jejuni capsule/Penner types. The invention also relates to a method of identifying Campylobacter jejuni types using the inventive primers in a multiplex PCR assay.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The present invention relates to non-volatile organic compositions having a VOC of about zero, a flash point above 14O0F, and a vapor pressure of less than seven millimeters of mercury (7mm Hg). The non- volatile organic compositions comprise an alkylated cyclicsiloxane having 5 to 8 repeating siloxane units, an alkylated cyclicsiloxane having 3 or 4 repeating siloxane units, and at least one glycol alkyl ether.

IPC Classes  ?

• C11D 7/50 - Solvents

Abstract

The present invention relates to recombinant chimeric molecules that are capable of providing T cell receptor (TCR) interaction and costimulation for activation and differentiation of pathogen-specific T cells toward effector T helper 1 (Th I) or T helper 2 (Th2) cells. The chimera may capable of elicit antibodies against pathogen-specific B cell epitope(s). The present invention also relates method of using these chimeric molecules in whole or as a component of a vaccine.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 9/14 - Particulate form, e.g. powders
• A61K 49/00 - Preparations for testing in vivo
• C12P 21/08 - Monoclonal antibodies

Abstract

The invention relates immunogenic polypeptides and epitopes from Plasmodium falciparum protein AMAl. The epitopes contain HLA class I binding motifs and stimulate an anti-malaria CD8+ T-cell response. The polypeptides can be incorporated into immunogenic formulations against malaria. Additionally, the antigens are useful for facilitating evaluation of immunogenicity of candidate malaria vaccines.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The invention provides novel malaria polypeptides expressed at the preerythrocytic stage of the malaria life-cycle. The antigens can be utilized to induce an immune response against malaria in a mammal by administering the antigens in vaccine formulations or expressing the antigens in DNA or other nucleic acid expression systems delivered as a vaccine formulation.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens

Abstract

A thermoelectric generator has a hot side heat exchanger comprising: a silicon carbide (SiC) honeycomb support with a plurality of passages. The passage walls are coated with a pyrophoric solid fuel such as red oxide (Fe2O3) in combination with a silicon (Si) binder. A quantum well thermoelectric device is positioned between the hot side heat exchanger and heat sink. The performance of the thermoelectric generator is comparable to fuel cells. The thermoelectric generator is small and portable.

IPC Classes  ?

• H01L 35/30 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the heat-exchanging means at the junction

Abstract

A method for manufacturing or preparing thin-film stacks that exhibit moderate, finite, stress-dependent resistance and which can be incorporated into a transduction mechanism that enables simple, effective signal to be read out from a micro- or nano-mechanical structure. As the structure is driven, the resistance of the intermediate layers is modulated in tandem with the motion, and with suitable dc-bias, the motion is directly converted into detectable voltage. In general, detecting signal from MEMS or NEMS devices is difficult, especially using a method that is able to be integrated with standard electronics. The thin-film manufacturing or preparation technique described herein is therefore a technical advance in the field of MEMS/NEMS that could enable new applications as well as the ability to easily develop CMOS-MEMS integrated fabrication techniques. Also disclosed are: (i) transducers where current flows across a piezo layer from one major surface to the opposite major surface; and (ii) methods of making a transducer the resistivity of a piezoresistive layer is decreased and/or the gauge factor of a piezoresistive layer is increased.

IPC Classes  ?

• H01L 41/083 - Piezo-electric or electrostrictive elements having a stacked or multilayer structure

Abstract

The present invention is directed to a CMOS integrated micromechanical device fabricated in accordance with a standard CMOS foundry fabrication process. The standard CMOS foundry fabrication process is characterized by a predetermined layer map and a predetermined set of fabrication rules. The device includes a semiconductor substrate formed or provided in accordance with the predetermined layer map and the predetermined set of fabrication rules. A MEMS resonator device is fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules. The MEMS resonator device includes a micromechanical resonator structure having a surface area greater than or equal to approximately 20 square microns. At least one CMOS circuit is coupled to the MEMS resonator member. The at least one CMOS circuit is also fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules.

IPC Classes  ?

• H03H 3/007 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks
• H03H 9/02 - Networks comprising electromechanical or electro-acoustic elements; Electromechanical resonators - Details
• H03H 3/00 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators

Abstract

PerchIorate-free green flare compositions are disclosed which, when burned, produce green smoke and flames. Methods of producing the compositions are also disclosed.

IPC Classes  ?

• C06C 15/00 - Pyrophoric compositions; Flints
• C06B 33/04 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide the material being an inorganic nitrogen-oxygen salt

Abstract

Perchlorate-free flare compositions are disclosed which, when burned, produce yellow smoke and flames. Methods of producing the compositions are also disclosed.

IPC Classes  ?

• C06C 15/00 - Pyrophoric compositions; Flints
• C06B 33/14 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide the material being two or more oxygen-yielding compounds at least one being an inorganic nitrogen-oxygen salt

Abstract

Perchlorate-free flare compositions are disclosed which, when burned, produce red smoke and flames. Methods of producing the compositions are also disclosed.

IPC Classes  ?

• C06C 15/00 - Pyrophoric compositions; Flints
• C06B 33/04 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide the material being an inorganic nitrogen-oxygen salt

Abstract

The invention relates to the construction of recombinant, immunodominant polypeptides against spotted fever group Rickettsia. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays of spotted fever. The proteins can also be used to induce immune response against spotted fever group Rickettsia.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens

Abstract

Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.

IPC Classes  ?

• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

A vaccine comprising an immunogenic preparation containing a Plasmodium antigen or a fragment thereof, wherein said antigen is selected from a group consisting of PyAg2, PfAg2, PvAg2, PkAg2, PoAg2, PmAg2, PbAg2, PcAg2 and a combination thereof. A vaccination method comprising administering a priming immunization preparation containing a Plasmodium antigen or fragment thereof, wherein said antigen is selected from a group consisting of PyAg2, PfAg2, PvAg2, PkAg2, PoAg2, PmAg2, PbAg2, PcAg2 and a combination thereof, and administrating a boosting immunization preparation containing said Plasmodium antigen or fragment, wherein said antigen is selected from a group consisting of PyAg2, PfAg2, PvAg2, PkAg2, PoAg2, PmAg2, PbAg2, PcAg2 and a combination thereof.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens

Abstract

This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.

IPC Classes  ?

• A61K 6/08 - Use of natural or synthetic resins
• A61C 5/00 - Filling or capping teeth

Abstract

This invention encompasses for an isolated Bacillus phage AP50 that has one or more nucleotide substitutions in the phage genome, whereby the one or more nucleotide substitutions increase lytic activity of the phage. In addition, the invention encompasses for proteins expressed by the phages, compositions containing the proteins and/or the phage as well as methods of using the Bacillus phage AP50 to test for the presence of B. anthracis.

IPC Classes  ?

• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/09 - Recombinant DNA-technology

Abstract

An immunogenic composition, and method of using the composition to elicit an immune response to Campylobacter jejuni. The composition is an isolated polysaccharide polymer composed of one or more forms of disaccharide polymers.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens

Abstract

A method for dyeing high density polyethelene fiber fabric, which includes applying an aliphatic stain on the fabric.

IPC Classes  ?

• D06P 1/00 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed

Abstract

The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprising administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins.

IPC Classes  ?

• A61K 31/12 - Ketones
• A01K 43/04 - Grading eggs
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Abstract

The invention relates to an immunogenic composition composed of secreted polypeptides derived from Campylobacter jejuni non-flagellar proteins that are coordinately expressed with the flagellar regulon. The invention also relates to a method of inducing an immune response to the non-flagellar protein polypeptides.

IPC Classes  ?

• A61K 39/40 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
• A61K 39/106 - Vibrio; Campylobacter

Abstract

A magnetostrictive alloy containing iron and gallium comprising: Fe100 - (x + y + z)GaxA1yCz; where x is of from about 5 at. % to about 30 at. %; where x + y is of from about 5 at. % to about 30 at. %; and where z is of from about 0.005 at. % to about 4.1 at. %. The alloys can also contain B and N.

IPC Classes  ?

• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties

Abstract

A pharmaceutical formulation capable of supplying replacement blood volume and tissue oxygenation as well as other functions, such as procoagulation and pharmacological interventions, in order to enhance survivability in patients with severe blood loss. The invention also discloses a formulation and method of using the - formulation in bridging severe blood loss using a multifunctional blood substitute in a prehospital setting.

IPC Classes  ?

• A61K 35/18 - Erythrocytes

Abstract

The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 1/00 - General processes for the preparation of peptides
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.

IPC Classes  ?

• A61K 39/108 - Escherichia; Klebsiella

Abstract

The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.

IPC Classes  ?

• A61K 39/108 - Escherichia; Klebsiella

Abstract

The inventive subject matter relates to a competitive method measuring stress biomarkers in bodily fluids including serum, urine and oral fluids including saliva. The inventive method measures biomarkers including Cortisol, melatonin and secretory IgA by fluorescence polarization fluorescence lifetime analysis or fluorescence resonance energy transfer.

IPC Classes  ?

• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention provides methods and compositions of enhancing the immune response to an antigen.

IPC Classes  ?

• A61K 39/07 - Bacillus
• A61P 31/04 - Antibacterial agents