INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA (ISTA) (Autriche)
Inventeur(s)
Matusik, Wojciech
Bickel, Bernd
Makatura, Liane
Wang, Bohan
Deng, Bolei
Wojtan, Chris
Chen, Yi-Lu
Abrégé
A method for forming a specification for a cellular metamaterial includes configuring a graph-based computation processor according to a graph-based computation specification to perform data processing steps, including steps to yield a specification of a unit cell for replication to form the cellular metamaterial. The data processing steps include forming a skeletal specification of a sub-cell of the unit cell from input data, characterizing at least one of a line and a surface within the sub-cell, forming a skeletal specification of the unit cell from the skeletal specification using one or more geometric transformations including a least one of a mirror transformation, a rotation transformation, and a scaling transformation, and performing the volumetric transformation of the skeletal specification of the unit cell to form a volumetric specification of the unit cell for replication to form the specification of a volume of the metamaterial including a number of unit cells.
Many quantum systems, including arrays of trapped atoms, trapped ions, and color centers in solid-state hosts, are controlled with optical control signals. As quantum systems increase in size to thousands of channels or more, however, it can be challenging to generate enough optical control signals to control them. A multi -wavelength reconfigurable optical control apparatus uses lasers, high-speed modulators, a reconfigurable spatial light modulator (SLMs), and a fast beam scanner to address thousands of qubits. The lasers generate beams at the qubits' resonant wavelengths; the modulators modulate the beams with control pulses at gigahertz rates; the SLM re-projects the beams into a geometry matched to the quantum operation and the geometry of the qubit array; and the beam scanner scans the beams across the qubit array at kilohertz to megahertz rate. This enables the control apparatus to address the entire array before the qubits' coherence time has elapsed.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
3.
SYSTEMS AND METHODS TO SYNTHESIZE ELECTROCATALYSTS AND COMPOSITIONS THEREOF
Systems and methods to synthesize electrocatalyst compositions are disclosed. The electrocatalysts can be synthesized via a suspension of a mixture of graphene oxide and a metal-containing powder in water that is irradiated by a laser to produce a laser-reduced graphene oxide. The irradiation can trigger photochemical or photothermal reactions that form carbide nanoparticles. Formation of the carbides can occur at ambient conditions, with the resulting carbides being formed with an evenly dispersed carbide catalyst. Once formed, these catalysts can be added to hydrogen evolution reaction due to its high catalytic activity and stability.
An actuator includes a motor and a gear train. The gear train is configured to couple the motor to a load and includes a first gear with a toothed outer section and a central section coupled to the toothed outer section by an elastic inner section. A difference in an angle of rotation of the toothed outer section and an angle of rotation of the central section causes tensile and/or compressive stress in the elastic inner section.
F16H 19/06 - Transmissions comportant essentiellement et uniquement des engrenages ou des organes de friction et qui ne peuvent transmettre un mouvement rotatif indéfini pour convertir un mouvement rotatif en mouvement alternatif et vice versa comportant un organe flexible sans fin
Quantum processors are provided. A first plurality of neutral atoms is provided in an active zone, each in a respective optical trap of a first array. A first logical qubit is encoded into the first plurality of neutral atoms by first and second lasers. The first plurality of neutral atoms is illuminated while in the active zone by at least the first or second laser, thereby applying a gate to the first logical qubit. The first plurality of neutral atoms is adiabatically moved from the active zone to a readout zone, each to a respective optical trap of a second array. The first plurality of neutral atoms is illuminated while in the readout zone by a third laser. An image of the first plurality of neutral atoms is captures while in the readout zone, thereby determining the state of the first logical qubit.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p.ex. codes de surface ou distillation d’état magique
An eyedrop assist device is configured for use with an eyedrop bottle in an environment defining a horizontal. To that end, the eyedrop assist device has a body with a proximal end and a distal end. Importantly, the body has a receiving region to receive the eyedrop bottle and forming a longitudinal axis. The eyedrop assist device also has an angle calibrator configured to produce first indicium identifying when the longitudinal axis of the receiving region forms a first angle, and a tilt sensor. Preferably, the tilt sensor is configured to produce second indicium when the longitudinal axis of the longitudinal axis of the receiving region is tilted to form a second angle relative to the horizontal. Since they are for different purposes, the first and second angles are different angles.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeux; Dispositifs pour mettre en place des verres de contact; Dispositifs pour corriger le strabisme; Appareils pour guider les aveugles; Dispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
7.
COMPOSITIONS AND METHODS FOR PEPTIDE-BASED MODULATORS OF HUMAN PAPILLOMAVIRUS ONCOPROTEIN E6
This disclosure relates to synthetic peptides of E6AP and complexes of synthetic peptides with HPV E16, methods of making such peptides and complexes, and methods of using such peptides and complexes for blocking, inhibiting, or preventing the interaction of E6AP with HPV E16. The synthetic peptides and complexes of synthetic peptides with HPV E16 can further comprise warheads to introduce covalent linkages between the synthetic peptides with HPV E16.
8.
COLLISION AVOIDANCE SYSTEM FOR USE IN A STATE-DEPENDENT DYNAMICAL SYSTEM
Disclosed are concepts, systems and techniques for control systems, and particularly for control systems capable of controlling autonomous systems (e.g., autonomous robotic systems such as a such as manipulator) such that the autonomous systems avoid dynamic obstacles during movement in three-dimensions. The disclosed are concepts, systems and techniques are appropriate for use in collision avoidance systems and related methods for use in a state-dependent dynamical system (DS). The described systems and method ensure impenetrability, preserve stability, and ensure convergence even in the presence of one or more non-convex obstacles. Thus, the disclosed concepts, systems and techniques herein allow systems to operate in environments in which dynamic complex, non-convex obstacles are present.
Systems and methods for cascaded compression of zero-dimensional nanostructures (0DNs) ae disclosed. The cascaded compression approach can be used to narrow the size distribution of nanopores with left skewness and ultra-small tail deviation, while keeping the density of nanopores increasing at each compression cycle. In some embodiments, a size distribution of existing nanopores can be compressed by a combination of shrinkage and expansion, with a new batch of nanopores being created, which can lead to increased nanopore density at the completion of each cycle. Moreover, cascaded compression of the 0DNs can allow for independent control of nanopore density, the mean diameter, the standard deviation, and the skewness of the size distribution.
Systems and devices capable of precise delivery of fluid, on the order of microliters and below, into a tissue or soft material, while concurrently measuring fluidic pressure in order to generate a pressure-volume curve from which material properties can be determined. Specifically, examples include systems and devices designed to conduct digital palpation of a tissue by measuring internal mechanical resistance using fluid delivered by a needle placed in the tissue. Examples include the use of the measurement of mechanical resistance, as well as other features, such as fracture strength, to differentiate tissue types, or tissue health, such as cancerous versus non-cancerous.
Described herein are engineered, non-naturally occurring systems and compositions comprising multimeric CRISPR-Cas complexes comprising a β-CASP polypeptide, a plurality of Cas polypeptides, and a guide molecule, packaging and delivery systems thereof, and methods of use thereof, for modifying target polynucleotides. In addition, described herein are engineered, non-naturally occurring systems and compositions comprising a class of small Cas proteins (Type II-B, II-C, and II-D Cas proteins) and methods of modifying target sequences using the Type II-B, II-C, II-D Cas proteins and systems thereof.
12.
LONG-TERM STABILIZATION, FORMULATION AND TABLETING OF LIVE MICROBIAL CELLS
Escherichia coli (E. coli) Saccharomyces boulardii (S. boulardii), Lactobacillus plantarum (L. plantarum)Ensifer meliloti (E. meliloti)E. coli, S. boulardii, L. plantarum,E. melilotiE. meliloti to a subject in need thereof, methods of inducing bacterial growth in a subject or in a cell, tissue, or biological sample, and methods of inhibiting an enteric pathogen in a subject or in a cell, tissue, or biological sample. Further provided herein are methods of treating dysbiosis in a subject in need thereof.
Aspects of the disclosure relate to non-naturally occurring polynucleotides encoding a Shank3 protein, AAV vectors comprising the polynucleotides, and gene therapy methods.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
Methods of detection are provided, comprising (i) obtaining a. sample, wherein the sample comprises target selected from biological cells and viruses; (ii) incubating the sample with polymer-coated magnetic beads to produce bead-target complexes; (iii) analyzing the bead-target complexes by Raman spectroscopy to produce a spectrograph; and (iv) detecting the presence of the bead-target complexes by analyzing the spectrograph.
G01N 33/483 - Analyse physique de matériau biologique
G01N 21/62 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
15.
OPTIMIZATION OF QUANTUM-ACTIVE DEFECTS AND SPINS IN CHEMICAL SYSTEMS USING MACHINE LEARNING
Systems and methods for the manufacture of improved quantum materials are provided. The techniques include generating, using a machine learning model, a regression model of a figure of merit describing the quantum material, the regression model being determined based at least in part on the characterized one or more quantum properties of individual samples of the quantum material and associated fabrication parameters. The techniques also include determining improved fabrication parameters using the regression model of the figure of merit and fabricating a new sample of the quantum material using the improved fabrication parameters.
In certain aspects, the invention provides methods and compositions for use in identifying a neutralizing status of a candidate antiviral agent. The invention also provides methods of determining one or more binding characteristics of glycan-binding agents.
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
17.
SOFT ROBOTIC SIMULATOR OF HEART FUNCTION AND DISEASE
A soft robotic, 3D-printed simulator of heart function and disease has been designed to recreate the anatomy and function of specific people and patients with heart disease, for use personalized cardiovascular medicine. Using clinical imaging data, this system re-creates the anatomy of the left ventricle (the main pumping chamber of the heart) and of the aorta (the main blood vessel in the body). A soft robotic heart sleeve recapitulates the pumping action of the heart during normal physiology and disease. A soft robotic aortic sleeve can be added to the system to recapitulate disease of the aortic valve (separating the left ventricle and the aorta).
Described herein is a design and optimization of a 1-MW inverter for a high-speed, high-specific-power motor drive. In some embodiments, an inverter system includes ten 100-kW inverter sets distributed around the periphery of the machine to drive ten separate sets of three-phase open-ended windings. Each inverter set includes three single-phase full-bridge inverters each of which drives an open-ended phase winding. The use of three single-phase full-bridge inverters for each inverter can yield an improved specific power as compared to either the three-phase bridge inverter or the active neutral-point clamped (ANPC) inverter in target applications. Disclosed inverter systems may be used with a 1-MW permanent magnet machine and associated thermal management system.
H02P 9/14 - Dispositions pour la commande de génératrices électriques de façon à obtenir les caractéristiques désirées à la sortie par variation du champ
A torsional spring includes cantilevered flexures extending radially inward from an outer ring to free ends configured to interface with a central hub. The flexures may be tapered and/or have a serpentine shape that can be optimized based on desired spring stiffness and packaging volume.
The present disclosure provides methods for preparing oligonucleotides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using cyclic- phosphorous nucleosides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using substituted benzyl alcohol nucleophiles. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using cyclic-phosphorous nucleosides and substituted benzyl alcohol nucleophiles.
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 19/11 - Radicaux pyrimidine avec le radical saccharide estérifié par des acides phosphoriques ou polyphosphoriques contenant un phosphate cyclique
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
21.
RECONFIGURABLE PRECAST CONCRETE CONSTRUCTION SYSTEM
Embodiments implement an apparatus for use in a building structure. Embodiments include at least two structural modules having a convex side oriented towards the common axis and a concave side oriented away from a common axis. Further, embodiments include member element defined by the at least two structural modules in coupled arrangement, the member element comprising a first end and a second end. A post-tensioning assembly is utilized including: (i) at least two anchors coupled to the member element at distinct locations at or between the first end and the second end, and (ii) a tensile element coupled to the at least two anchors in a manner providing a post-tensioning force between the at least two anchors and along the common axis.
E04C 3/00 - Eléments de construction de forme allongée, conçus pour supporter des charges
E04C 3/22 - Poutrelles; Solives, fermes ou structures analogues à des fermes, p.ex. préfabriquées; Linteaux; Traverses en béton ou autre matériau analogue à la pierre, p.ex. avec armatures ou tirants composés d'éléments réunis en ligne
E04C 3/26 - Poutrelles; Solives, fermes ou structures analogues à des fermes, p.ex. préfabriquées; Linteaux; Traverses en béton ou autre matériau analogue à la pierre, p.ex. avec armatures ou tirants précontraint
E04C 3/293 - Poutrelles; Solives, fermes ou structures analogues à des fermes, p.ex. préfabriquées; Linteaux; Traverses formés d'éléments de différents matériaux les matériaux étant de l'acier et du béton
E04C 3/34 - Colonnes; Piliers; Arcs-boutants en béton ou autre matériau analogue à la pierre, avec ou sans éléments de coffrage permanents, avec ou sans armature interne ou externe, p.ex. recouvrements métalliques
E04C 5/08 - Eléments spécialement adaptés pour être utilisés dans des constructions précontraintes
E04B 1/24 - Structures comportant des éléments porteurs allongés, p.ex. colonnes, poutres, ossatures les pièces porteuses étant métalliques
Hydrogel compositions that are capable of separating analytes in a mixture of analytes, and related methods, are generally described. For example, a hydrogel composition can be mixed with a sample comprising, at least, a first analyte and a second analyte, and the hydrogel composition can partition the first analyte selectively over the second electrolyte. The first analyte remains confined by the hydrogel composition, while the second analyte remains unconfined, facilitating separation of the two analytes.
A61K 31/536 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p.ex. 1,2-oxazines condensées en ortho ou en péri avec des systèmes carbocycliques
A61K 31/537 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p.ex. 1,2-oxazines condensées en spiro ou formant une partie de systèmes cycliques pontés
Described are structures and techniques for supporting a thermal radiation shield in a superconducting magnet. The thermal radiation shield can be supported off of a cold mass using low thermal conductivity structural supports. Structural supports, specifically thermal radiation shield supports and bumpers, may be installed between a cold mass and the radiation shield to mitigate deflections of the radiation shield. Thermal radiation shield supports are attached to both the cold mass and the radiation shield. Bumpers may be used in addition to thermal radiation shield supports and have a first end attached to either the cold mass or the thermal radiation shield and a second end not physically coupled to any structure.
H01F 6/06 - Bobines, p.ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines
G01R 33/3815 - Systèmes pour produire, homogénéiser ou stabiliser le champ magnétique directeur ou le champ magnétique à gradient utilisant des électro-aimants avec des bobines supraconductrices, p.ex. leurs alimentations
The present disclosure features methods for modifying fertility. In some embodiments, the disclosure provides contraceptive compositions and methods of using the same.
A method for predictive identification of relevant documents to clinical users during medical record entry includes receiving data characterizing a current clinical context, the data including a medical note input by the clinical user during one or more prior clinical tasks and processing the data characterizing the current clinical context to identify a set of one or more source documents relevant to a future clinical task of the clinical user from a plurality of source documents, wherein the processing is based at least in part on a model of clinical activity determined from prior activities of clinicians during medical record entry.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G06F 16/16 - Opérations sur les fichiers ou les dossiers, p.ex. détails des interfaces utilisateur spécialement adaptées aux systèmes de fichiers
G06F 16/2457 - Traitement des requêtes avec adaptation aux besoins de l’utilisateur
Genome editing tools for use in systems designed to deliver large genetic elements are disclosed herein. A genome editing system is described, which includes i) an R2 element enzyme or other non-LTR site specific retrotransposon element and ii) a payload RNA, wherein the payload RNA comprises an insertion region and optionally one or more of a 5' homology region, a 3' homology region, and a protein binding element, wherein the insertion region comprises a template for a small or large nucleic acid insertion into the genome, and wherein the R2 element enzyme or other non-LTR site specific retrotransposon element comprises a targeting domain, a reverse transcriptase domain, and a nickase domain. Also disclosed are cells edited using such a genome editing system, methods for editing a genome, and compositions comprising cells edited with this genomic editing system.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
An improved hydrocephalus stent has been developed which exhibits greater stability at the site of implantation and less occlusion. The expandable hydrocephalus stent device includes a first side, a middle and a second side, wherein the stent device is compressible into an endoscopic delivery catheter, wherein the stent device expands after release from the delivery catheter between the prepontine cistern and the third ventricle, the first side expanding within the prepontine cistern and the second side expanding within the third ventricle. The stent device includes a central channel to funnel fluid from the third ventricle into the prepontine cistern and has a curved surface between the first and the second sides of the central channel to secure the device to the membrane between the prepontine cistern and the third ventricle.
According to some embodiments, a high-frequency (HF) self-shielded inductor includes: an outer shell having a distributed or quasi-distributed gap and two or more notches; an inner core disposed within the outer shell and having a distributed or quasi-distributed gap; a coil winding disposed between the inner core and the outer shell; two endcaps disposed at opposite ends of the inner core and the outer shell; and a conductive shield disposed around the outer shell.
31.
SYSTEMS, METHODS, AND COMPOSITIONS FOR CYSTIC FIBROSIS GENE EDITING
Provided herein are systems, methods, and compositions for cystic fibrosis gene correction using programmable genomic editing. The programmable genomic editing can efficiently edit cystic fibrosis genes, such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
32.
SYSTEMS AND METHODS TO MONITOR NOCICEPTION, PAIN, AND PAIN RELIEF
Systems and methods are provided for monitoring nociception and/or pain in a patient. The system includes optodes configured be placed on the patient's scalp and forehead to acquire functional near-infrared spectroscopy (fNIRS) data from the medial frontopolar cortex (mFPC) region and the somatosensory (SI) regions of the patient. The system also includes a control unit coupled to the optodes. The control unit is to obtain the acquired fNIRS data from the optodes, process the acquired fNIRS data, and recognize signatures in the fNIRS data associated with a pain event in real time, where the signatures include measures of dissociation between the fNIRS data from the mFPC region and the fNIRS data from the SI region. The control unit is also configured to output a pain event classification to a user based on recognizing the signatures.
The present disclosure provides compositions which enable the delivery of cargo, including therapeutic agents such as RNA, to organs or tissues in addition to the liver, lungs, and spleen, such as brain, heart, kidney, and muscle tissue. More specifically, the compositions comprise a plurality of lipid particles comprising an agent, cationic lipids and ionizable lipid.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 31/711 - Acides désoxyribonucléiques naturels, c. à d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
34.
MEASURING THE NET MAGNETIC MOMENT OF A GEOLOGICAL SAMPLE
A method for determining the net magnetic moment of a sample having a magnetization distribution includes using a magnetic-field sensor to acquire a field map within a non-spherical area external to the sample, the field map comprising magnetic-field data that represents the magnetic field produced by the magnetization field of the sample; determining a plurality of representations of a magnetic field external to the sample, each of the representations being a spherical-harmonic multipole expansion that approximates the magnetic field, the expansion being a truncated expansion, selecting a final representation from among the representations based at least in part on the field map and on properties of the representations; and determining the net magnetic moment of the sample based at least in pail on the final representation.
Systems and methods described herein provide techniques for identifying a reproductive state of one or more subjects. The systems and methods, in some embodiments, processes data relating to movement activity and is used to identify the reproductive state of the subject. The systems and methods may use one or more machine learning models.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
342433, with efficient magnetoelectric coupling are disclosed. The MENDs may exhibit a robust response to magnetic field stimulation in neurons decorated with MENDs at a density of 1 µg/mm2even though individual-particle potentials may be below the neuronal excitation threshold. MENDs injected into the ventral tegmental area of genetically intact mice at concentrations of 1 mg/mL may enable remote control of reward behavior and provide a mechanistic optimization of magnetoelectric neuromodulation.
H01F 1/06 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriés; Emploi de matériaux spécifiés pour leurs propriétés magnétiques en matériaux inorganiques caractérisés par leur coercivité en matériaux magnétiques durs métaux ou alliages sous forme de particules, p.ex. de poudre
H01F 1/44 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriés; Emploi de matériaux spécifiés pour leurs propriétés magnétiques en liquides magnétiques, p.ex. ferrofluides
An article includes an identifier fiber. The identifier fiber includes a photonic structure that, upon illumination, produces an optical response having an optical parameter value. The optical parameter value, at least in part, identifies a particular article characteristic. The inclusion of the identifier fiber in the article indicates, at least in part, that the article has the particular article characteristic.
38.
ENGINEERED TYPE V CAS POLYNUCLEOTIDES WITH REDUCED IMMUNOGENICITY AND USES THEREOF
Engineered Type V Cas polypeptides with reduced immunogenicity, CRISPR-Cas systems thereof, compositions thereof, delivery systems thereof, and methods of use thereof for modifying target polynucleotides, such as, for example, in cells.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
C07K 14/195 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
Disclosed is a hybrid polymeric system containing (a) a polymer matrix containing polymeric particles dispersed within the polymer matrix, and (b) therapeutic, diagnostic, nutraceutical, and/or prophylactic agents encapsulated in the polymeric particles, for these agents. The polymer matrix and the polymeric particles have different degradation rates, such that the degradation rate of the polymer matrix is less than that of at least one of the polymeric particles, such that when the hybrid polymeric system is administered to a subject in need thereof, the hybrid polymeric system remains at the site of administration, while the encapsulated polymeric particles degrade to release these agents. The hybrid polymeric system is particularly suited for progressive and/or chronic diseases or disorders that require prolonged periods of release of therapeutic, prophylactic, or diagnostic agents, and diseases or disorders that require repeated administration of these agents.
According to some embodiments, a system includes: a first neuron configured to generate a first firing waveform; a second neuron configured to generate a second firing waveform; an electrochemical ionic (EIS) synapse; and a circuit electrically connecting the first and second neurons via the EIS synapse and configured to modulate conductivity of the electrical connection provided by the EIS synapse based on relative timing of the first and second firing waveforms. The waveform shapes can be selected to implement a spike-timing-dependent plasticity (STDP) learning rule in the EIS synapse.
G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
41.
ENGINEERED TYPE II CAS POLYNUCLEOTIDES WITH REDUCED IMMUNOGENICITY AND USES THEREOF
Engineered Type II Cas polypeptides with reduced immunogenicity, CRISPR-Cas systems thereof, compositions thereof, delivery systems thereof, and methods of use thereof for modifying target polynucleotides, such as, for example, in cells.
Described are central solenoid (CS) retaining structures and related assembly techniques. Also described are assembly techniques for a tokamak fusion reactor.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Barhydt, Kentaro
Osele, Obumneme, Godson
Okamura, Allison
Asada, Haruhiko, Harry
Abrégé
A flexible robotic limb and associated methods of operation are disclosed. The flexible robotic limb may include a flexible backbone and a channel extending along a length of the flexible backbone. A flexible inflatable structure may be configured to invert into and evert out from a distal end portion of the flexible backbone. In some embodiments, extension of the flexible backbone and inversion and eversion of the flexible inflatable structure may be controlled independently to permit a relative length of an everted portion of the flexible inflatable structure extending beyond a distal end portion of the flexible backbone to be controlled.
A robotic hand includes one or more fingers. Each finger includes an articulated rigid skeleton including a number of rigid sections connected by one or more joints, wherein at least some of the rigid sections are connected to one or more actuators by linking elements for imparting motion to the articulated rigid skeleton, and an elastic material formed around the articulated rigid skeleton and at least some of the linking elements such that the articulated rigid skeleton, the at least some of the linking elements, and the elastic material form a unitary structure.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Barhydt, Kentaro
Osele, Obumneme, Godson
Okamura, Allison
Asada, Haruhiko, Harry
Abrégé
Segmented flexible robotic limbs with low bending stiffnesses and high compressive stiffnesses are disclosed. The disclosed flexible robotic limbs may include inverting/everting flexible inflatable structures that include a plurality of serially arranged interconnected chambers that include connections between adjacent interconnected chambers. The connections fluidly coupling adjacent interconnected chambers may have smaller transverse cross sectional areas perpendicular to a longitudinal axis of the robotic limb than the adjacent interconnected chambers in the inflated configuration.
B25J 9/06 - Manipulateurs à commande programmée caractérisés par des bras à articulations multiples
F01B 19/04 - "Machines" ou machines motrices à déplacement positif du type à parois flexibles à membrures flexibles tubulaires
F15B 15/10 - Dispositifs actionnés par fluides pour déplacer un organe d'une position à une autre; Transmission associée à ces dispositifs caractérisés par la structure de l'ensemble moteur le moteur étant du type à diaphragme
46.
NUCLEASE-GUIDED NON-LTR RETROTRANSPOSONS AND USES THEREOF
Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.
C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p.ex. Lactobacillus, Micromonospora
A61K 31/711 - Acides désoxyribonucléiques naturels, c. à d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
47.
RESOURCE-EFFICIENT COHERENT OPTICAL FREQUENCY TRANSFER FOR DISTRIBUTED QUANTUM COMPUTING AND THE QUANTUM INTERNET OF THINGS
A unified quantum network architecture is introduced that seamlessly applies to all memory types while sharply reducing experimental overhead. The scheme depends on the following elements: A unified quantum network framework based on photon heralding. As a unified quantum network framework, a scheme for optically heralded entanglement that applies to superconductor-to-optical interfaces equally as to other memory-photon interfaces (such as spin-photon interfaces, and others). To address the challenges noted above, a scheme termed "Universal Quantum Bus" (UQB) is introduced. UQB is described for connecting diamond color centers across a telecom fiber network, however the scheme works equally for all other memory types.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
G06N 10/60 - Algorithmes quantiques, p.ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
48.
SYSTEMS AND METHODS FOR EFFICIENT DATASET DISTILLATION USING NON-DETERMINISTIC FEATURE APPROXIMATION
OSS|). When combined with a modified Platt scaling loss, the disclosed algorithm can provide at least a 100-fold speedup over a Kernel-Inducing Points (KIP) algorithm and can run on a single graphics processing unit. The disclosed Random Feature Approximation Distillation (RFAD) algorithm can perform competitively with other dataset condensation algorithms in accuracy over a range of large-scale datasets, both in kernel regression and finite-width network training. The disclosed techniques can be effective on tasks such as model interpretability and data privacy preservation.
G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
G06V 10/776 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source Évaluation des performances
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
Methods of implanting biomaterials and devices in a patient, such as methods that include arranging an adhesive composition between and in contact with a biomaterial or a device, and a surface of a tissue of the patient. An adhesive composition may be configured to form at a surface of a tissue a conformal interface that reduces or minimizes infiltration of inflammatory cells at the conformal interface.
A system and method for measuring qubit states. In some embodiments, the system includes a first qubit and a readout circuit, the readout circuit being configured to perform a direct readout of the state of the first qubit.
51.
RAPID AND SCALABLE SOLUTION-BASED FABRICATION OF QUANTUM DOT AND QUANTUM ROD 2D ARRAYS USING DNA ORIGAMI
Ultrafast methods to prepare high-density DNA functionalized nanoparticles using solution-based fabrication and application to aligned 2D QR lattices with nanometer scale spatial accuracy are described.
52.
FANZORS ARE RNA-GUIDED NUCLEASES ENCODED IN EUKARYOTIC GENOMES
The invention relates to compositions and methods tor targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, a non-naturally occurring, engineered composition comprising: (a) a Fanzor polypeptide comprising an RuvC domain; and (b) a fRNA molecule comprising a scaffold and a reprogrammable target spacer sequence, wherein the fRNA molecule is capable of forming a complex with the Fanzor polypeptide and directing the Fanzor polypeptide to a target polynucleotide sequence.
A method of forming deterministic perovskite nanocrystals on a substrate is disclosed. The method includes preparing a perovskite forming precursor solution comprising a mixture of a solvent, perovskite precursors, and optionally surface passivation ligands and/or a host matrix. This perovskite forming precursor solution is deposited on a substrate by spin-coating, blade-coating or other deposition techniques to produce a layer comprising perovskite precursors, also referred to as a deposited perovskite forming precursor film. Then, a region of the film is locally heated to transform the perovskite precursors into perovskite nanocrystals and deterministically form an arbitrary pattern comprising clusters of the perovskite nanocrystals with control down to a single nanocrystal. The localized heating may be accomplished using thermal scanning probe lithography or lasers or a combination.
C30B 29/60 - Monocristaux ou matériaux polycristallins homogènes de structure déterminée caractérisés par leurs matériaux ou par leur forme caractérisés par la forme
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
54.
ELECTROSTATICALLY ACTUATED DEPLOYABLE SPACE STRUCTURES
An electrostatic thin-shell structure concept capable of actively controlling the shape of large area systems with minimal mass overhead and complexity is described. The structure comprises an assembly of collapsible thin-shell cells for which the cross-section follows the classical collapsible tubular mast architecture. Two conductive electrodes are added to the top and bottom flanges of the cell. An electrostatic force develops between top and bottom electrodes upon voltage application, which flattens the cross-section and causes the cell to expand longitudinally. When multiple layers of these cells are bonded to each other, the controlled differential expansion of each layer can be harnessed to cause global bending.
Flow devices for irrigation, also referred to as emitters or drip emitters, having improved operating parameters are disclosed. The emitters can be low-pressure and compact, designed for use within an irrigation tube or line, also referred to as inline, and can enable affordable, clean-energy technology for drip irrigation. The emitter can include a diaphragm pocket, a channel, and/or a labyrinth passage recessed within the body to regulate flow. The emitter can be designed for low activation pressure, consistent pressure compensation operation up to 4 bars of inlet pressure, and compact as compared to conventional emitters. In some embodiments, the channels of the labyrinth passage can be sufficiently wide to support superior clog resistance while having a flow-cross section that can allow a particle sized up to about 0.425 mm to flow therethrough without clogging.
A01G 25/02 - Systèmes d'arrosage placés au-dessus du sol qui utilisent des canalisations perforées ou des canalisations avec accessoires pour la distribution, p.ex. pour l'irrigation goutte à goutte
B01J 13/02 - Fabrication de microcapsules ou de microbilles
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
57.
CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF
Provided herein are bifunctional compounds that bind cyclin-dependent kinase 9 (CDK9) and/or promote targeted ubiquitination for the degradation of CDK9, a protein whose dysregulation is implicated in certain cancers. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating cancer, methods of promoting the degradation of CDK9 and/or IKZF1, and methods of promoting the selective degradation of CDK9 (e.g., over IKZF1) by a compound or composition described herein.
Described in certain exemplary embodiments herein are engineered Anti-CRISPR (Acr) polypeptides and delivery systems engineered for delivery to the cytosol and/or nucleus of cells. In certain embodiments, an engineered Acr polypeptide comprises an Acr polypeptide operatively coupled to a cargo delivery molecule, wherein the cargo delivery molecule is capable of binding or otherwise interacting with a pore-forming polypeptide. Also described in certain exemplary embodiments are methods of Acr delivery to cells via the engineered Acr polypeptides and delivery systems of the present disclosure.
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY (République de Corée)
Inventeur(s)
Li, Ju
Yoon, Moonsu
Dong, Yanhao
Cho, Jaephil
Abrégé
A mechanochemical process to synthesize single-crystalline cathode powders for the formation of cathodes in a lithium-ion battery includes mixing a transient metal oxide precursor with a lithium salt mixture. Thereafter, a mechanical agitation process may be applied to selectively melt the lithium salt mixture to form a molten salt liquid that wets, corrodes, and separates the grain boundaries of secondary particles in the transient metal oxide precursor. As a result, the secondary particles are deagglomerated resulting in a colloidal dispersion of primary particles. The mixture is then calcined to facilitate growth of single-crystalline particles from the primary particles, thus forming a single-crystalline cathode powder. The single-crystalline particles exhibit large particle size and little to no phase separation, thus improving electrochemical performance. This highly scalable process can be used to synthesize single-crystalline cathode powders from chemical-grade precursors or black mass.
Aspects of the disclosure relate to expression cassettes encoding miniShank3 proteins, AAV vectors comprising the expression cassettes, and gene therapy methods. In particular, the expression cassettes is formulated to further comprise AAV9 capsids, and the gene therapy is useful for treating neuroveleopmental disorders such as autism spectrum disorder (ASD) and Phelan-McDermid syndrome.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
A61K 31/711 - Acides désoxyribonucléiques naturels, c. à d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
What is described is a method of growing a two-dimensional (2D) material on a substrate, the method comprising: (a) forming a mask layer on the substrate; (b) forming a trench in the mask layer, the trench having sidewalls formed in the mask layer surrounding an exposed portion of the substrate; and (c) depositing a nucleus of the 2D material on the exposed portion of the substrate and growing the nucleus into a single-domain monolayer of the 2D material, wherein the depositing and the growing of the nucleus is performed at a temperature less than 705 °C.
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
C23C 14/04 - Revêtement de parties déterminées de la surface, p.ex. au moyen de masques
C23C 14/06 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le matériau de revêtement
C23C 14/22 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le procédé de revêtement
C23C 16/30 - Dépôt de composés, de mélanges ou de solutions solides, p.ex. borures, carbures, nitrures
62.
DETERMINATION OF PATH WITH ENHANCED OR OPTIMIZED COLLECTION AND TIME IN DYNAMIC ENVIRONMENTS
Techniques for use in connection with determining a collection, time, and usage optimized route for a vehicle may include obtaining collection, usage, and time optimized reachable sets, obtaining a Pareto front of Pareto solutions for optimum time and optimum collectible, reachable at a target final location and target collectible level, and using the Pareto solutions to provide an optimized route for the vehicle. The vehicle may be guided using the optimized route and may collect an enhanced quantity of a collectible along the optimized route.
Disclosed herein are silicates and/or salts and methods of production and uses thereof. For example, methods of producing an amorphous silicate and/or a salt from materials comprising silicates are disclosed. As another example, use of silicates and/or salts in the formation of cementitious materials is also disclosed.
C04B 18/06 - Résidus de combustion, p.ex. produits d'épuration des fumées, des émanations ou des gaz d'échappement
C04B 28/02 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates contenant des ciments hydrauliques autres que ceux de sulfate de calcium
The techniques described herein relate to systems, apparatus, articles of manufacture, and methods for improving speech understanding of users. An example method includes obtaining at least one speech comprehension metric indicating a degree to which the user comprehends audible speech. The method further includes obtaining speech information to be output to the user, the speech information representing audible speech communicated to the user. The method additionally includes determining modulated speech information using a cognitive speech model with the at least one speech comprehension metric and the speech information, and outputting the modulated speech information to the user.
Systems and methods are provided herein for inducing quench in a non-insulated superconducting magnet. Some techniques described herein provide for operating the non-insulated superconducting magnet by applying a first current to the non-insulated superconducting magnet, and inducing quench in the non-insulated superconducting magnet at least in part by applying a second current to the non-insulated superconducting magnet, wherein the second current is opposite in direction to the first current.
H01F 6/02 - Etouffement de la supraconductivité; Dispositions pour la protection lors de la phase de transition vers l'état de conductivité normale
H02H 7/00 - Circuits de protection de sécurité spécialement adaptés pour des machines ou appareils électriques de types particuliers ou pour la protection sectionnelle de systèmes de câble ou ligne, et effectuant une commutation automatique dans le cas d'un chan
H01F 6/06 - Bobines, p.ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines
66.
TYPE I-D CRISPR-ASSOCIATED TRANSPOSASE AND TYROSINE RECOMBINASE TRANSPOSON SYSTEMS
The invention provides for systems and methods for inserting large polynucleotides into precise locations in a target polynucleotide. In one aspect, the systems comprise an engineered Type I-D/Tn7 CRISPR-associated transposase system (CAST) comprising a Tn7-like transposase linked to or otherwise capable of associating with a Type I-D CRISPR-Cas complex (Tn7-CAST I-D). In another aspect, the systems comprise a Tn7-like transposase comprising a modular target site selection protein, called TnsF, that may be engineered to reprogram the Tn7-like transposase to facilitate insertion at different sites in a target polynucleotide. In another aspect, the systems comprise a transposon system comprising a tyrosine recombinase which provides for scar-less insertion of large donor sequences into target polynucleotides. Also provided are methods for modifying target polynucleotides using the systems; polynucleotides encoding the systems; delivery systems for delivering the components of the systems; and cells and biological products modified by or modified to include the systems.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
G02F 1/017 - Structures avec une variation de potentiel périodique ou quasi périodique, p.ex. superréseaux, puits quantiques
H01L 29/12 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués
H10N 60/30 - Dispositifs commutables entre les états supraconducteur et normal
G06N 10/60 - Algorithmes quantiques, p.ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
G06N 10/80 - Programmation quantique, p.ex. interfaces, langages ou boîtes à outils de développement logiciel pour la création ou la manipulation de programmes capables de fonctionner sur des ordinateurs quantiques; Plate-formes pour la simulation ou l’accès aux ordinateurs quantiques, p.ex. informatique quantique en nuage
68.
SYSTEMS AND METHODS FOR MAPPING OF GASTROINTESTINAL TRACT
A catheter system for obtaining a pressure profile of a gastrointestinal (GI) tract includes a catheter configured to be inserted endoluminally into the GI tract. The catheter includes an outer sheath defining a first lumen and sensing unit enclosed within the first lumen. The sensing unit includes a plurality of pressure sensors spaced apart along the flexible printed circuit board that is supported on a support structure. The support structure is made of a shape memory material that is configured to transition from a first configuration to a second configuration following insertion of the catheter into the GI tract. The second configuration includes a first region shaped to conform to a first portion of the GI tract and a second region shaped to conform to a second portion of the GI tract that is distinctly shaped from the first portion of the GI tract.
A61B 5/392 - Détection des contractions gastro-intestinales
A61B 1/273 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments pour l'appareil digestif supérieur, p.ex. œsophagoscopes, gastroscopes
According to certain embodiments, a composition comprising a polymer of intrinsic microporosity (PIM) is described. In some embodiments, the PIM comprises a polyamide comprising a first micropore-generating moiety (e.g., a spirobifluorene moiety) crosslinked with at least one second micropore-generating moiety (e.g., a Tröger's base moiety) via an amide bond. The first moiety and the second moiety may be substantially rigid such that neither moiety contains any carbon-carbon or carbon-heteroatom single bonds. The resulting rigid polyamides formed from the micropore-generating units have advantageous properties, including, for example, sufficiently small pore sizes, large fractional free volumes, and high surface areas. Furthermore, the pore sizes, fractional free volumes, and surface areas of the polyamides may advantageously be tuned depending on the choice of the first moiety and the second moiety.
A barrier coating that is resistant to delamination includes a glass-ceramic phase and a metallic phase. The glass-ceramic phase protects an underlying substrate against environmental hazards. The metallic phase provides ductile reinforcement of the barrier coating, in part, by forming a percolating network throughout the barrier coating, thus improving delamination resistance. In one example application, the barrier coating is applied to a component of an oxygen-rich turbopump (e.g., a turbine blade) for use in a reusable rocket engine. In this example, the barrier coating protects, for example, a component formed of a Ni superalloy against particle impact ignition by an oxygen-rich gas stream.
F01D 5/28 - Emploi de matériaux spécifiés; Mesures contre l'érosion ou la corrosion
F02K 9/60 - Moteurs-fusées, c. à d. ensembles fonctionnels portant à la fois le combustible et son oxydant; Leur commande utilisant des propergols liquides ou gazeux - Détails non prévus ailleurs
C23C 28/00 - Revêtement pour obtenir au moins deux couches superposées, soit par des procédés non prévus dans un seul des groupes principaux , soit par des combinaisons de procédés prévus dans les sous-classes et
Disclosed herein is a near infrared (nIR) fluorescent nanosensor for detecting iron species, comprising a complexation of individual single-walled carbon nanotubes (SWNT), wherein the SWNT are nIR fluorescent, and a water-soluble polymer. The nIR fluorescent nanosensors offer a specific and sensitive sensing platform for quantification and speciation of dissolved or bioavailable Fe(II) and Fe(III) in both their free ionic and chelated forms, and have been demonstrated for use in detection of iron via root uptake in planta, as well as in the detection of "free" or non-transferrin bound iron (NTBI) in human serum.
C08G 69/32 - Polyamides dérivés, soit des acides amino-carboxyliques, soit de polyamines et d'acides polycarboxyliques dérivés de polyamines et d'acides polycarboxyliques à partir de diamines aromatiques et d'acides aromatiques dicarboxyliques avec des groupes amino et carboxylique liés tous deux aromatiquement
C08L 77/10 - Polyamides dérivés de groupes amino et carboxyle liés aromatiquement soit d'acides aminocarboxyliques, soit de polyamines et d'acides polycarboxyliques
C08F 238/00 - Copolymères de composés contenant une ou plusieurs liaisons triples carbone-carbone
C08L 49/00 - Compositions contenant des homopolymères ou des copolymères de composés possédant une ou plusieurs liaisons triples carbone-carbone; Compositions contenant des dérivés de tels polymères
B82Y 40/00 - Fabrication ou traitement des nanostructures
72.
CONTROL METHODS AND INTERFACES FOR CONTROLLING MACHINES
Embodiments related to methods and systems for using control arms operated in a controller space that is linearly mapped to a world space for controlling operation of a machine with an end effector are disclosed.
G05G 9/047 - Mécanismes de commande manuelle équipés d'un seul organe de commande travaillant avec plusieurs organes commandés, p.ex. en sélection ou simultanément l'organe de commande étant manœuvré de différentes manières indépendantes, chacune de ces manœuvres individuelles entraînant un seul organe commandé dans lesquels la manœuvre de l'organe de commande peut être effectuée de plusieurs manières simultanément l'organe de commande étant manœuvré à la main autour d'axes orthogonaux, p.ex. manches à balai
E02F 9/20 - Entraînements; Dispositifs de commande
G05G 1/01 - Agencements de plusieurs organes de commande les uns par rapport aux autres
E02F 3/28 - Dragues; Engins de terrassement entraînés mécaniquement avec des outils excavateurs montés sur un bras plongeur ou à godets, p.ex. plongeurs, godets
G05D 1/02 - Commande de la position ou du cap par référence à un système à deux dimensions
Aspects of the present disclosure relate to modified yeast cells capable of producing increased quantities of squalene as compared to unmodified yeast cells and methods of using the same.
C07K 14/37 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de champignons
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12P 5/02 - Préparation des hydrocarbures acycliques
74.
ELECTROMECHANICAL DEVICES FOR THE BURST RELEASE OF INDEFINITELY STABLE DRY POWDER DRUGS
Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., < 3 cm3), lightweight (e.g., < 2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., < 5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo. Additionally, disclosed herein is a platform for the long-term in vivo closed loop delivery of emergency rescue drugs.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61J 1/03 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour pilules ou comprimés
A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p.ex. de remèdes, dans les cavités du corps
B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, ou de forme sphérique ou similaire, p.ex. cachets ou pilules
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
75.
HANGING DROP-BASED MICROFLUIDIC SYSTEM, DEVICE, AND METHOD FOR LIQUID EXCHANGE FOR VITRIFICATION OF A SPECIMEN
A hanging drop device for vitrification of a specimen includes a housing, a plurality of microfluidic channels disposed in the housing and a plurality of inlets disposed in the housing. Each inlet is connected to and in fluid communication with at last one of the plurality of microfluidic channels. The hanging drop device further includes an outlet disposed in the housing and connected to and in fluid communication with at least one of the plurality of microfluidic channels, and an opening disposed in the housing and connected to and in fluid communication with each of the plurality of microfluidic channels. The opening is configured to form a hanging drop chamber from a liquid loaded into the opening and the hanging drop chamber is configured to receive the specimen.
G01N 33/483 - Analyse physique de matériau biologique
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
76.
MODULAR RYDBERG ARCHITECTURES FOR FAULT TOLERANT QUANTUM COMPUTING
Modular Rydberg architectures for fault tolerant quantum computing are provided. A first array and a second array of neutral atoms are provided. Each neutral atom has a first state and an excited Rydberg state. Each neutral atom is arranged to impose a Rydberg blockade on at least its nearest neighbors in its array when in the excited Rydberg state, thereby implementing a plurality of physical qubits. Each array comprises data qubits, and syndrome qubits. The syndrome qubits are configured to implement a quantum error correcting code with respect to the data qubits. Each array includes a subarray of communication qubits having a lower dimensionality than the array. Each communication qubit of the first subarray forms a Bell pair with one communication qubit of the second subarray. The first and second arrays of neutral atoms are configured to interact with each other only via the communication qubits.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p.ex. codes de surface ou distillation d’état magique
77.
METHODS AND APPARATUS FOR ADAPTIVE, INTEGRATED MYCOTECTURE FOR RAPID DEPLOYMENT AND SCALEUP
A data collection and analysis method aligns data across processes and products. The method includes collecting data in real time; mapping the data to a matrix between function and data points; and multiplexing the data. An integrated manufacturing process of a plurality of intermediate and final products from mycelium includes collecting data from the system at intervals; analyzing the data; iteratively optimizing the manufacturing process from the processed data; and generating environmental certifications from the processed data. An adaptive, unified mycotecture platform in conjunction with a digital recording and analysis system monitors and iteratively optimizes growth, harvest, packaging, quality control, and payment. The platform includes a manufacturing facility(ies) having a growing section, a storage section, and a manufacturing section. The facility has one or more of sensors, rapid-deploy scaffolding, a reconfigurable press, a brick extractor, a mixer, an autoclave, a laboratory, bar coding, and an interactive software application.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
G05B 19/414 - Structure du système de commande, p.ex. automate commun ou systèmes à multiprocesseur, interface vers le servo-contrôleur, contrôleur à interface programmable
G06F 7/08 - Tri, c. à d. rangement des supports d'enregistrement dans un ordre de succession numérique ou autre, selon la classification d'au moins certaines informations portées sur les supports
G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combin
G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
Apparatus and methods are described for excavating earthen material with millimeter- wave (MMW) radiation or a combination of MMW radiation and mechanical apparatus. The MMW radiation can reduce costs and hazards associated with excavation using mechanical means only and/or explosives. MMW-assisted excavation has significant energy advantages over optical or long- wavelength microwave excavation techniques.
H05B 6/80 - Appareils pour applications spécifiques
E21B 21/16 - Procédés ou appareils pour nettoyer les trous de forage par jet de fluide, p.ex. en utilisant l'air d'échappement du moteur utilisant des fluides gazeux
E21B 7/15 - Forage thermique, p.ex. forage à la flamme la chaleur étant produite par l'électricité
E21B 43/26 - Procédés pour activer la production par formation de crevasses ou de fractures
79.
BIODEGRADABLE LIPIDS AND FORMULATIONS FOR INTRAMUSCULAR, IN VITRO, AND EX VIVO TRANSFECTION OF MRNA
Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).
C07D 257/02 - Composés hétérocycliques contenant des cycles comportant quatre atomes d'azote comme uniques hétéro-atomes du cycle non condensés avec d'autres cycles
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p.ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 19/00 - Médicaments pour le traitement des troubles du squelette
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A detector for gamma irradiation comprises an oxygen ion conducting polycrystalline solid, has positively charged grain boundaries and is coupled to electrodes that measure changes in the poly crystalline solid's ionic conductance. The poly crystalline solid may include lightly doped Gd-doped CeCh, a polycrystalline ion conducting ceramic. The steady state passivation of space charge barriers at grain boundaries that may act as virtual electrodes, capturing radiation-induced electrons, in turn lowering space charge barrier heights, and thereby exclusively modulating the ionic carrier flow within the ceramic electrolytes. Such behavior may allow for an electrical response under low fields, i.e., < 2 V/cm. The polycrystalline solids disclosed herein may be used in inexpensive, sensitive, low-power and miniaturizable solid- state devices, uniquely suited for operating in harsh (high temperature, high humidity, pressure, and/or corrosive) environments.
1YY represents a single bond, an alkylene group having 1-14 carbon atoms, a substituted alkylene group having 1-14 carbon atoms, a heteroalkylene group having 1-14 carbon atoms, and a substituted heteroalkylene group having 1-14 carbon atoms. X represents a basic functional group.
A61K 47/24 - Composés organiques, p.ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p.ex. cyclométhicone ou phospholipides
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
82.
MEANS AND METHODS TO TARGET ENDOGENOUS CONDENSATES
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Allemagne)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventeur(s)
Cissé, Ibrahim
Lee, Choongman
Abrégé
The invention relates to a system for modifying a target biomolecule that is associated to an endogenous intracellular condensate formed by an intracellular protein comprising an Intrinsically Disordered Region (IDR), or to a system for modifying a chemical or physical property of an endogenous intracellular condensate. The system of the invention comprises as its minimal components an IDR polypeptide sequence tract comprising the Intrinsically Disordered Region of the intracellular protein, and an effector polypeptide domain capable of covalently modifying said target biomolecule.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p.ex. kinases (2.7)
Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.
Methods for transferring optically active features, such as meta-atoms and diffractive elements, formed on a planar surface to a non-planar surface with high precision are described. Optical devices having meta-atoms or other diffractive features located on non-planar and/or planar surfaces can be fabricated using the described methods. Related optical systems and components are described.
Techniques are providing for mitigating overcurrents in superconducting magnets by adding a closed loop of superconductor to the magnet that acts as an electromagnetic shield. A time-varying external magnetic field may induce a current in the closed loop, thereby generating a magnetic field that opposes the external magnetic field, and reducing the amount of current induced by the external magnetic field in the primary current-carrying superconductor of the magnet. As a result, the effect of overcurrents can be reduced or removed.
Devices, systems, and methods described herein relate to a muscle interface and methods of use. The muscle interface may include an implant comprising a plurality of fine wires configured to be disposed in muscle tissue and to detect an electrical impedance at the muscle tissue; and a processor configured to determine a state of the muscle tissue based on the detected electrical impedance.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
87.
EVOLVING RANDOM HETEROPOLYMERS TOWARDS CATALYTICALLY ACTIVE MATERIALS
The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.
B01J 31/06 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques contenant des polymères
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, ARMY RESEARCH LABORATORY (USA)
Inventeur(s)
Saha, Uday
Waks, Edo
Siverns, James D.
Hannegan, John
Prabhu, Mihika
Englund, Dirk
Quraishi, Qudsia
Abrégé
A system includes a quantum source and an optical device coupled to the quantum source. The quantum source is configured to emit an entangled photon. The optical device is configured to route the entangled photon to one or more outputs. In some aspects, the optical device can include a photonic integrated circuit (PIC). Advantageously the system can provide a routing scheme to route (e.g., passively, actively, dynamically, or a combination thereof) entangled photons from one or more quantum sources (e.g., trapped ion, single-photon source, quantum emitter, etc.) between different nodes, a quantum frequency conversion scheme to match near-infrared photons (750 nm to 1260 nm) and/or telecommunication photons (1260 nm to 1675 nm) entangled with photons from one or more quantum sources to an operating wavelength of the optical device (e.g., PIC), programmable routing and entanglement distribution, and scalable long-distance quantum networks.
B82Y 20/00 - Nano-optique, p.ex. optique quantique ou cristaux photoniques
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
89.
ELECTROCHEMICAL SYSTEMS AND METHODS FOR RECYCLING LITHIUM-ION BATTERIES
Disclosed herein are systems and methods for electrochemical recycling of lithium-ion batteries and components thereof. For example, in some embodiments, an electrochemical system is provided for the recovery of nickel, manganese, copper, lithium, and/or cobalt. In some embodiments, the system comprises one or more electrochemical cells, wherein each electrochemical cell comprises a working electrode and a counter electrode, the working electrode and counter electrode separated by a separator. In some embodiments, the systems described herein are configured for the simultaneous recovery of two or more metal (ions) for a given electrochemical cell. For example, in some embodiments, during operation of an electrochemical cell as described herein, cobalt and/or nickel may be deposited on a (working) electrode while manganese is deposited on a (counter) electrode. The systems and methods described herein may be particularly advantageous for the recovery of raw materials from spent lithium-ion batteries.
The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy). The method comprises administering to a neuronal cell of the subject a vector comprising a mini Singlet Oxygen Generator (miniSOG) in the presence of monomers of 3,3'-diaminobenzidine or aniline and N phenyl p-phenylenediamine and irradiating at least a portion of the neuronal cell to induce polymerization of poly(3,3'-diaminobenzidine) or polyaniline.
Photonics has benefited immensely from advanced silicon manufacturing. By leveraging mature complementary metal-oxide-semiconductor (CMOS) process nodes, unprecedented device uniformity and scalability have been achieved at low cost. However, some functionalities, such as optical memory, Pockels modulation, and magneto-optical activity, are challenging or impossible to provide with group-IV materials alone. Heterogeneous integration promises to expand the range of capabilities within silicon photonics. Unfortunately, existing heterogeneous integration protocols are incompatible with the active silicon processes offered at most photonic foundries. Here, we disclose a heterogeneous integration platform that enables wafer-scale, multi-material integration with active silicon-based photonics, with no change to the existing foundry process. Furthermore, this heterogeneous integration platform enables a class of high-performance devices, including: a grating coupler with peak coupling efficiency reaching 93%, an antenna with peak diffraction efficiency in excess of 97%, and a broadband adiabatic polarization rotator with conversion efficiency exceeding 99%.
According to some embodiments, the cell culture system allows for the passage of cells in high-throughput cell culture applications. Unlike enzymatic detachment processes, the cell culture system, in some embodiments, limits any imparted damage onto the cell. Additionally, the lack of reliance on enzymes for cell detachments (e.g. trypsin) reduces and/or prevents the accrual of genetic mutations that can occur during enzymatic detachment processes. The cell culture system, in some embodiments, is capable of passaging and/or detaching cells at rates convenient for high throughput cell culturing and/or automated cell culturing regimes. Advantageously, the cell culture system, in certain embodiments, provides sufficient adhesion to promote cell growth and proliferation, but is capable of reducing the adhesion between the cell and the surface upon application of the electric field.
A61B 5/24 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci
B29C 35/02 - Chauffage ou durcissement, p.ex. réticulation ou vulcanisation
H01B 1/12 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisés; Emploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques substances organiques
93.
DETECTION OF OLIGONUCLEOTIDES USING ANCHORED SINGLE-WALLED CARBON NANOTUBE CORONA PHASE
The present invention provides a system and method for detecting an analyte in a sample comprising semiconducting single-walled carbon nanotubes (SWCNTs) and surface- adsorbed nucleic acids, wherein the surface-adsorbed nucleic acids comprise a complementary region and at least one anchor, wherein the complementary region comprises a nucleic acid sequence that is complementary' to and/or hybridizes to a target region of the analyte, and the at least one anchor comprises a nucleic acid sequence that is not complementary' to the target region of the analyte.
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p.ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
94.
COMPOSITIONS FOR DETECTION OF FLUOROCARBONS AND RELATED ARTICLES, SYSTEMS, AND METHODS
Compositions, articles, systems, and methods for detection of fluorocarbons are generally described. In certain embodiments, for example, a sensing material that comprises a coupled-multichromophore is described. The coupled-multichromophore may be capable of energy transport and/or diffusion between individual sites of the coupled-multichromophore. In certain embodiments, for example, the coupled-multichromophore comprises individual sites that arc linked through delocalized orbitals such that the coupled-multichromophore is capable of energy transport and/or diffusion through each individual site of the coupled-multichromophore. The sensing material comprising the coupled-multichromophore may be configured to detect the presence of an analyte, such as a fluoroalkyl species (e.g., a per- and/or polyfluoroalkyl substance). For example, in some embodiments, the coupled-multichromophore comprises at least one chromophore that displays a change in electromagnetic radiation (e.g., light) emission in response to a presence of the analyte. The change in electromagnetic radiation emission may be detected to determine the presence of the analyte.
G01N 21/62 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
C09B 69/10 - Colorants polymères; Produits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
The present invention provides polymer compositions for use in cosmetic nail polish compositions. More particularly, the present disclosure relates to the introduction of cleavable conomoner additives into an existing polymer composition to produce a chemically deconstructable composition. Methods and compositions for removing the nail polish composition are also disclosed.
A61K 8/04 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière Émulsions
A61K 8/18 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A45D 29/00 - Instruments de manucure ou de pédicure
Described are concepts, systems, methods, and machines for providing a device (e.g., electronic device) on a transferable, ultra-thin substrate. The described concepts, systems, methods, and machines may be used to produce an electronic device on a transferable, ultra-thin substrate using only solution-based (e.g., wet) processing techniques. The described concepts systems, methods, and machines may also be used to produce a releasable substrate for the electronic device having a certain desired characteristic. Structures including a device are also described. The structures may include the device, a releasable substrate, and a removable release liner carrier. Also described are systems, methods, and machines for removing a release liner carrier from a releasable substrate and device, for applying the releasable substrate and device to a permanent substrate, and for reusing the release liner carrier to produce another device.
Described is an insulative layer for use in systems utilizing a high temperature superconductor (HTS). The insulative layer comprises a first layer of an insulative material, a second layer of an insulative material and a third layer of an electrically conductive material disposed the first and second layers. The electrically insulating material of the first layer and the electrically insulating material of the second layer are both resistant to grinding forces. The third layer is provided from a material having a resistance to oxidative degradation, weather, and radiation, as well as resistance to abrasive and fictional wear at cryogenic temperatures. In one application, the insulative layer may be disposed at an interface between a toroidal field (TF) coil and a central solenoid (CS) of a high temperature superconducting magnet.
Techniques are described for improving quench damage resiliency in non-insulated (NI) high temperature superconductor (HTS) magnets. The techniques may include tuning an amount of HTS tape within turns of a winding of an NI-HTS magnet to reduce variation in critical current across the winding, and/or may include adjusting the turn-to-turn resistance of the windings by adjusting turn-to-turn spacing between windings and thereby reduce variations in joule heating between turns during a quench.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Surendranath, Yogesh
Toh, Wei Lun
Kanan, Matthew
Agarwal, Rishi Gupta
Charnay, Benjamin Peter
Chen, Yuxuan
Rabinowitz, Joshua Avraam
Abrégé
Disclosed herein is a method of forming a precipitate, comprising: a. providing a salt solution; b. performing electrochemical reactions in the salt solution to produce a solution of lower pH and a solution of higher pH; c. providing a silicate-containing material containing Mg2+ and/or Ca2+ ions; d. treating the silicate-containing material with the solution of lower pH to dissolve at least a portion of the silicate-containing material and generate a second solution with higher pH; e. combining the solution generated in (d) with at least a portion of the solution with higher pH generated in (b) to form the precipitate and a second salt solution; and f. recycling the second salt solution generated in step (e) by adding (b).
Devices, systems, and methods herein are generally directed to a robotic control system that comprises: a wearable robot comprising at least one actuated joint; at least one muscle-tendon interface configured to measure at least one physiological signal; a torque set point processor configured to receive the at least one physiological signal from the at least one muscle tendon interface and estimate a muscle-tendon state corresponding to a human motor intention and to compute at least one augmentation joint torque based on the muscle-tendon state; and a torque controller configured to apply the at least one augmentation joint torque to the at least one actuated joint of the wearable robot.
A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61F 2/50 - Prothèses non implantables dans le corps
brevets
