THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Hotlani, Hitesh
Abrégé
An implantable medical device and a method of deduplicating data collected by the implantable medical device are provided. The method includes storing data, captured by the implantable medical device, in a non-volatile memory device of the implantable medical device, assigning a unique number, generated from a random number generator or counter, to each data block of the data, and deduplicating the data by deleting at least one of two or more data blocks that are associated with the same unique number.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian
Mech, Brian
Elyahoodayan, Sahar
Abrégé
A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/365 - Stimulateurs cardiaques commandés par un paramètre physiologique, p.ex. par le potentiel cardiaque
3.
TISSUE STIMULATION APPARATUS AND METHODS OF MAKING THE SAME
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Jenney, Christopher, Reed
Talbot, Neil
Calderon, Joseph
Elyahoodayan, Sahar
Brandt, William, Andrew
Abrégé
A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
4.
DEVICES AND METHODS FOR STIMULATING AN AURICULAR BRANCH OF A VAGUS NERVE
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian Michael
Talbot, Neil
Dearden, Brian
Abrégé
A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Greenberg, Robert J.
Abrégé
The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g., stimulation pulse amplitude) to levels that cause a therapeutic result in a matter of minutes instead of months as compared to related VNS systems.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 3/00 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Hotlani, Hitesh
Abrégé
The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian Michael
Hotlani, Hitesh
Abrégé
The disclosure provides systems and methods for system for vagus nerve stimulation (VNS), using a VNS stimulator implanted in a human subject and configured to transmit electrical stimulation pulses to a vagus nerve of the human subject; and at least one sensor configured to detect a predefined pattern of tactile input, a bodily gesture, and/or a voice command from the human subject, wherein the VNS stimulator includes a controller configured to modulate at least one stimulation parameter of the electrical stimulation pulses based at least in part on the tactile input, bodily gesture, and/or voice command from the human subject.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
8.
AUTOMATICALLY-ALIGNING MAGNETIC FIELD SYSTEM AND METHOD OF FABRICATION
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lin, Susanna
Dearden, Brian
Loo, Justin
Abrégé
A wireless power transfer device (10) includes a first transmitting coil (100) oriented along a first axis (100a) and including a first ferrite rod (120); a second transmitting coil (200) on the first transmitting coil (100), oriented along a second axis (200a) different from the first axis (100a), and including a second ferrite rod (220); and a nonmagnetic layer (300L) magnetically decoupling the first ferrite rod (120) from the second ferrite rod (220) in an area of overlap (300) between the first and second ferrite rods (120, 220), the first ferrite rod (120) and the nonmagnetic layer (300L) being fabricated utilizing additive manufacturing.
H01F 41/02 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateurs; Appareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants
H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Calderon, Joseph, L.
Hillery, Edward
Lin, Susanna, M.
Abrégé
An implantable medical device (IMD) charger apparatus may include an IMD charger including a housing defining a bottom surface, a primary coil located within the housing, and a fastener on the bottom surface of the housing, and a charger support, mounted on the IMD charger, including a bottom surface, and movable between a first state and a second state. The IMD charger and the charger support may be respectively configured such that the IMD charger fastener is above the charger support bottom surface when the charger support is in the first state and the IMD charger fastener is at or below the charger support bottom surface when the charger support is in the second state.
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
H01F 27/00 - AIMANTS; INDUCTANCES; TRANSFORMATEURS; EMPLOI DE MATÉRIAUX SPÉCIFIÉS POUR LEURS PROPRIÉTÉS MAGNÉTIQUES - Détails de transformateurs ou d'inductances, en général
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Farkas, Leslie
Dearden, Brian
Loo, Justin
Abrégé
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
H02J 50/40 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant plusieurs dispositifs de transmission ou de réception
H02J 50/80 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre l’échange de données, concernant l’alimentation ou la distribution d’énergie électrique, entre les dispositifs de transmission et les dispositifs de réception
11.
SYSTEMS AND METHODS FOR VAGUS NERVE MONITORING AND STIMULATION
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Mech, Brian V.
Talbot, Neil
Shelton, Brian M.
Calderon, Joseph L.
Greenberg, Robert J.
Abrégé
The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g, epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g, vagal tone and/or physiological or other biomarkers).
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Jenney, Christopher, Reed
Strickland, Timothy
Abrégé
An electrode lead including an elongate lead body and a nerve cuff (or other nerve contact element) including an electrically insulative cuff body (or other contact body) affixed to the distal end of the lead body and at least one electrically conductive coil partially embedded in the cuff body (or other contact body) such that there are non-embedded portions, which together define a flexible coil contact that is associated with the front outer surface of the cuff body (or other contact body), and embedded portions.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
13.
METHOD AND APPARATUS FOR PRE-ALIGNMENT OF AN AUTOMATICALLY ALIGNING MAGNETIC FIELD SYSTEM
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian
Shelton, Brian
Farkas, Leslie G.
Abrégé
A wireless power transfer system includes a wireless power transfer device configured to determine a magnetic field, from among a plurality of directionally different potential magnetic fields that the wireless power transfer device is configured to generate, that has, at a receiver coil of an electronic device, a direction aligned with the receiver coil.
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
H02J 50/40 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant plusieurs dispositifs de transmission ou de réception
H02J 50/70 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre la réduction des champs de fuite électriques, magnétiques ou électromagnétiques
14.
WAKEFULNESS AND SLEEP STAGE DETECTION USING RESPIRATION EFFORT VARIABILITY
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian Michael
Elyahoodayan, Sahar
Abrégé
The present disclosure generally relates to systems and methods for monitoring and/or the sleep stage of an individual using one or more sensors, and methods of treating medical conditions related thereto (e.g., obstructive sleep apnea).
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/0205 - Evaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p.ex. de l'état cardiaque et respiratoire
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
15.
ELECTRODE LEADS HAVING MULTI-APPLICATION HELICAL NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Brandt, William, Andrew
Dearden, Brian, Ralph
Abrégé
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Mech, Brian V.
Greenberg, Robert J.
Abrégé
The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.
A61N 1/00 - SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE ÉLECTROTHÉRAPIE; MAGNÉTOTHÉRAPIE; THÉRAPIE PAR RADIATIONS; THÉRAPIE PAR ULTRASONS Électrothérapie; Circuits à cet effet
A61N 1/02 - SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE ÉLECTROTHÉRAPIE; MAGNÉTOTHÉRAPIE; THÉRAPIE PAR RADIATIONS; THÉRAPIE PAR ULTRASONS Électrothérapie; Circuits à cet effet - Parties constitutives
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
17.
ELECTRODE LEADS HAVING NERVE CUFFS AND ASSOCIATED SYSTEMS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Jenney, Christopher, Reed
Gotlib, Oren
Calderon, Joseph
Brandt, William, Andrew
Talbot, Neil
Abrégé
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Kohler, Daniel G.
Abrégé
A method of multi-factor authentication includes receiving, by a first electronic device, a partial digital certificate including partial certificate information omitting at least one authentication factor from complete certificate information, and a signature encrypting a first hash of the complete certificate information with a certificate authority private key. The method also includes obtaining the first hash by decrypting, by the first electronic device, the signature with a certificate authority public key corresponding to the certificate authority private key; generating, by the first electronic device, a second hash based on the partial certificate information in the partial digital certificate and the at least one authentication factor; and comparing, by the first electronic device, the second hash to the first hash.
G06F 21/33 - Authentification de l’utilisateur par certificats
G06F 21/34 - Authentification de l’utilisateur impliquant l’utilisation de dispositifs externes supplémentaires, p.ex. clés électroniques ou cartes à puce intelligentes
H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Klein, Valma
Abrégé
A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abrégé
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
H02J 50/70 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre la réduction des champs de fuite électriques, magnétiques ou électromagnétiques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neal H.
Abrégé
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61F 5/56 - Dispositifs pour prévenir le ronflement
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Elyahoodayan, Sahar
Shelton, Brian, M.
Talbot, Neal, H.
Abrégé
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61N 1/00 - SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE ÉLECTROTHÉRAPIE; MAGNÉTOTHÉRAPIE; THÉRAPIE PAR RADIATIONS; THÉRAPIE PAR ULTRASONS Électrothérapie; Circuits à cet effet
A61F 5/56 - Dispositifs pour prévenir le ronflement
24.
ELECTRODE LEADS HAVING MULTI-APPLICATION NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian Ralph
Shelton, Brian, M.
Talbot, Neil
Abrégé
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian M.
Elyahoodayan, Sahar
Suri, Harshit R.
Abrégé
The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Greenberg, Robert J.
Suri, Harshit R.
Calderon, Joseph L.
Dearden, Brian R.
Abrégé
Systems for treating obstructive sleep apnea having an implanted stimulator with an internal sensor configured to generate sensory data corresponding to movement of the thoracic or abdominal cavity of a patient during respiration. The system includes a wireless communications link between the stimulator and at least one external sensor for sensing a patient's physiological parameter and is used to augment the sensory data from the internal sensor. The stimulator includes a stimulation system configured to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve to treat sleep apnea.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
27.
IMPLANTABLE INFUSION DEVICES WITH CLOSED LOOP SENSING AND ASSOCIATED METHODS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian R.
Petrovich, John G.
Abrégé
Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.
H02J 50/10 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Ng, Boon Khai
Calderon, Joseph L.
Abrégé
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lee, Edward K. F.
Suri, Harshit R.
Abrégé
A medical system and method of communicating between a telemetry controller and a plurality of medical devices implanted within a patient is provided. Communication links are respectively established between the telemetry controller and the implanted medical devices. The communication links are respectively amplitude modulated by the implanted medical devices at modulation levels using load modulation. Received signal strength indicators (RSSIs) of the amplitude modulated communication links for the implanted medical devices are measured. A variation of the RSSIs is decreased by modifying, based on the measured RSSIs, at least one modulation level at which the respective at least one communication link is amplitude modulated by the respective implanted medical device(s).
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lee, Edward K. F.
Suri, Harshit R.
Abrégé
A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
H04L 27/02 - Systèmes à courant porteur à modulation d'amplitude, p.ex. utilisant la manipulation par tout ou rien; Modulation à bande latérale unique ou à bande résiduelle
H04B 14/00 - Systèmes de transmission non caractérisés par le milieu utilisé pour la transmission
32.
STIMULATOR SYSTEMS AND METHODS FOR OBSTRUCTIVE SLEEP APNEA
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Suri, Harshit
Calderon, Joseph L.
Molnar, Gregory Frederick
Goding, Jr., George S.
Atyabi, Alanie
Schmidt, Siegmar
Dai, William
Dearden, Brian R.
Keenan, Desmond B.
Abrégé
An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian
Suri, Harshit
Lee, Edward, K.F.
Abrégé
In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
34.
NERVE CUFF ELECTRODES FABRICATED USING OVER-MOLDED LCP SUBSTRATES
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schmidt, Siegmar
Ng, Boon Khai
Dearden, Brian R.
Hansen, Morten
Abrégé
An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schmidt, Siegmar
Dai, William A.
Ng, Boon Khai
Abrégé
Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.
G01L 9/00 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pression; Transmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent
G01L 19/04 - Moyens pour compenser les effets des variations de température
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Rodriguez, Saul
Han, Dianna (dan)
Istoc, Emil
Abrégé
A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
H04L 29/06 - Commande de la communication; Traitement de la communication caractérisés par un protocole
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
H04L 29/08 - Procédure de commande de la transmission, p.ex. procédure de commande du niveau de la liaison
H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schmidt, Siegmar
Dai, William A.
Abrégé
An implantable pressure sensor device and devices incorporating an implantable pressure sensor are disclosed. The implantable pressure sensor may include a housing with a deflectable wall, and may be incorporated into a housing of an implantable medical device such as an implantable pulse generator. The pressure sensor may monitor respiration by measuring the deflection of the deflectable wall caused by expansion of the thoracic wail or ribcage.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
38.
IMPLANTABLE DEVICES AND METHODS FOR MONITORING COPD IN PATIENTS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Hansen, Morten
Keenan, Desmond B.
Abrégé
A medical monitoring system and method for monitoring a patient is provided. A sensor is implanted within the patient. A biomarker is detected via the implanted sensor within the patient. The detected biomarker is indicative of a neural respiratory drive (NRD) of the patient. An NRD index value is generated based on the detected biomarker.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Keenan, Desmond, B.
Hansen, Morten
Dearden, Brian, R.
Schmidt, Siegmar
Dai, William, A.
Abrégé
An upper airway stimulator for treating obstructive sleep apnea is described. In some embodiments, the upper airway stimulator monitors the phase difference between ribcage expansion and abdomen expansion to detect apneic events and stimulates to alleviate those events. In some embodiments, the upper airway stimulator applies primary stimulation when an apneic event is not detected and secondary stimulation when an apneic event is detected. In some embodiments, the upper airway stimulator applies primary stimulation when the patient is not in an apneic position and secondary stimulation when the patient is in an apneic position.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
40.
INDUCTIVE LINK COIL DE-TUNING COMPENSATION AND CONTROL
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Griffith, Glen A.
Abrégé
An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil. A variable impedance element is connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the variable impedance element can tune the impedance of the system.
H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
H02J 50/80 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre l’échange de données, concernant l’alimentation ou la distribution d’énergie électrique, entre les dispositifs de transmission et les dispositifs de réception
C08F 220/06 - Acide acrylique; Acide méthacrylique; Leurs sels métalliques ou leurs sels d'ammonium
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
C08F 220/20 - Esters des alcools polyhydriques ou des phénols polyhydriques
C08F 220/32 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle contenant des radicaux époxyde
C08F 220/36 - Esters contenant de l'azote contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle
C08F 220/58 - Amides contenant de l'oxygène en plus de l'oxygène de la fonction carbonamide
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Calderon, Joseph
Hillery, Edward
Lockhart, Joseph
Abrégé
An interface for coupling with a percutaneously implantable lead is described. The interface includes a rotation based system to engage the terminal connector of the lead. The interface includes a brake which retains the lead in the lead port through friction, but allows the lead to exit the lead port if sufficient force is applied. The interface can be coupled with the lead without removing a stylet or stiffening wire from the lead.
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
H01R 4/50 - Connexions par serrage; Connexions par ressort utilisant une came, un coin, un cône ou une bille
H01R 13/52 - Boîtiers protégés contre la poussière, les projections, les éclaboussures, l'eau ou les flammes
H01R 13/639 - Moyens additionnels pour maintenir ou verrouiller les pièces de couplage entre elles après l'engagement
H01R 31/06 - Pièces intermédiaires pour joindre deux pièces de couplage, p.ex. adaptateur
H01R 24/58 - Contacts espacés le long de l'axe longitudinal d’engagement
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Jiang, Guangqiang
He, Tom
Abrégé
The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Jiang, Guangqiang
He, Tom
Abrégé
The various implementations described herein include methods used to manufacture a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the method includes providing a tubular structure having an outer surface and providing a coil having an outer surface and comprised of a plurality of loops. The method further includes joining at least a portion of the outer surface of the coil to the outer surface of the tubular structure.
ALFRED E MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Griffith, Glen
Abrégé
An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian R.
Shelton, Brian M.
Wolfe, James H.
Abrégé
A charger that evaluates the effectiveness of the charging field generated by the charger at an implantable device. The charger includes a charging coil, a communication module, and a processor. The processor can include instructions to determine the effectiveness of the charging field based on one or several signals or communications received from the implantable device. The charger can use the determination of the effectiveness of the charging field to vary the strength of the charging field and/or to prompt the user to move the charger with respect to the implantable device.
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian R.
Wolfe, James H.
Khemani, Manish
Abrégé
A charger including a class E power driver, a frequency-shift keying ("FSK") module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
48.
HIGH EFFICIENCY MAGNETIC LINK FOR IMPLANTABLE DEVICES
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Dearden, Brian R.
Griffith, Glen A.
Abrégé
Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel.
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
49.
MULTI-BRANCH STIMULATION ELECTRODE FOR SUBCUTANEOUS FIELD STIMULATION
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian, M.
Hansen, Morten
Abrégé
A multi-branch stimulation electrode is disclosed herein. The multi-branch stimulation electrode can include a plurality of branches that extend from a hub. The branches can each include one or several stimulation contacts that can deliver an electrical current to tissue contacting the stimulation contacts. The stimulation contacts can be electrically connected with the lead. The lead can extend from the hub and can be connected with the pulse generator. The branches can include features to facilitate implantation including, for example, one or several removable stiffening elements.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
50.
HIGH RELIABILITY WIRE WELDING FOR IMPLANTABLE DEVICES
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schmidt, Siegmar
Abrégé
Methods of making an implantable pulse generator are disclosed herein. The implantable pulse generator can include a body defining an internal volume and a plurality of wires extending from out of the internal volume of the body. Some of these wires can be connected, either directly or indirectly to a lead via a welded joint. The welded joint can be created by first resistance welding and then laser welding some of the wires to a connector.
ALFRED E. MANN FOUNDTION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Shelton, Brian, M.
Dearden, Brian, R.
Wolfe, James, H.
Abrégé
Systems, methods, and devices for wireless recharging of an implanted device. In response to receiving identification information from an implanted device, a charger can set an electrical field to a first field strength and receive first field strength information from the implanted device. The charger can then set the electrical field to a second field strength and receive second field strength information from the implanted device. This information relating to the first and second field strengths can be used to determine whether to recharge the implanted device.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Byers, Charles, L.
Hetlinger, Chris, J.
Abrégé
A microfluidic flow rate sensor includes a droplet within a channel and a droplet movement detector that generates a signal based on the position and/or movement of the droplet within the channel. A processor determines the flow rate of a fluid through the channel based on the signal received from the droplet movement detector. In one example, the droplet movement detector is an optical detector, such as a combination of a lens and an image capturing device. In other examples, the droplet is electrically conductive, and at least a portion of the channel is conductive or includes electrical contacts. The position of the droplet within the channel is determined by observing the electrical characteristics of the channel.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lee, Edward K. F.
Abrégé
A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
H03K 3/012 - Modifications du générateur pour améliorer le temps de réponse ou pour diminuer la consommation d'énergie
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lee, Edward K. F.
Abrégé
A successive approximation ADC made of a low voltage configurable differential amplifier and low voltage logic circuits which can convert a high voltage analog input to a digital equivalent. The differential amplifier can be configured as either an op amp or a comparator depending upon the mode of operation. An input capacitor C1 is switchably coupled to an electrode selected for voltage sampling. A switched capacitor array C2 is coupled across the differential amplifier input and output. A SAR coupled to the switched capacitor array provides a digital output corresponding to the sampled analog voltage. During a sampling interval and a charge transfer interval, the differential amplifier is configured as an op amp. During the transfer interval, the voltage on the input capacitor multiplied by the ratio C1/C2 is transferred to the switched capacitor array. During an analog to digital conversion interval, the ADC converts the analog voltage to an equivalent digital output.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
H03M 1/46 - Valeur analogique comparée à des valeurs de référence uniquement séquentiellement, p.ex. du type à approximations successives avec convertisseur numérique/analogique pour fournir des valeurs de référence au convertisseur
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Oberg, Keith
Abrégé
Methods and systems for biosensing are disclosed, based on microchannel surface plasmon resonance. A surface plasmon resonance (SPR) sensor (100) for detecting the presence of a target analyte in a fluid, comprising: a light source (105); a light transmissive substrate (112); a metal coating (114) of gold, silver or copper disposed on the substrate; a test SPR element formed in the metal coating, the test SPR element comprising: at least one test microchannel (122) in the metal coating, the at least one test microchannel having at least one aperture (124) for the passage of light from the light source through the substrate, the at least one test microchannel configured to sustain a test plasmon resonance wave, wherein the test plasmon resonance wave emits a test surface plasmon emission (SPE); and a first coating (126) in the test microchannel, the first coating comprising capture molecules selected to interact with the target analyte; a test detector (130) configured to detect the intensity of the light of the test channel (120)SPE in a predetermined wavelength band; and a reference SPR element formed in the substrate, the reference SPR element comprising: at least one reference microchannel (142) in the metal coating, the at least one reference microchannel having at least one aperture (144) for the passage of light from the light source through the substrate, the at least one reference microchannel configured to sustain a reference plasmon resonance wave, wherein the reference plasmon resonance wave emits a reference SPE, a reference detector (150) configured to detect the intensity of the light of the reference SPE in the predetermined wavelength band; and a controller (160) coupled to the test detector and the reference detector. The sensor can be implanted in a human body and can communicate and be powered wirelessly with an external coil placed in proximity to the implanted sensor or with a coil in an adhesive, external patch.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
56.
FEEDBACK CONTROLLED COIL DRIVER FOR INDUCTIVE POWER TRANSFER
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Lee, Edward, K.F.
Abrégé
A fully integrated feedback controlled coil driver (500) is disclosed for inductive power transfer to electronic devices. For efficient power transfer, a voltage across a switch (516) that switchably couples the coil (512) between a DC input power source (501) and ground is sampled and compared with a preselected reference voltage (536) to generate an error voltage (542). The error voltage (542) is integrated over time and compared to a voltage ramp (554). The value of the integrated error voltage relative to the voltage ramp is used to obtain an optimal on time for the switch (516) such that coil current is maximized for a given DC input power.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02J 5/00 - Circuits pour le transfert d'énergie électrique entre réseaux à courant alternatif et réseaux à courant continu
57.
IMPLANTABLE SHUNT SYSTEM AND ASSOCIATED PRESSURE SENSORS
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schmidt, Siegmar
Byers, Charles, L.
Jiang, Guangqiang
Dearden, Brian
Gord, John
Abrégé
A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal re¬ chargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use of the pressure sensor module is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. The use of integrated circuit chips and an internal coil with an optional ferrite core in the pressure sensor module provides for low power consumption and reliable signal processing. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Hess, Phillip, B.
Nercessian, Patrick
Abrégé
A system and method for improving the processing of communications signals received in the presence of narrowband interference signals. The received communications signals are time sampled and transformed into a series of spectral terms in the frequency domain that are then evaluated to identify narrowband interference signals. The identified narrowband interference terms can be calculated to a value that will optimize the corrupted spectral terms resulting from the communication, and an inverse transformation can be used to generate a time domain signal that is free from interference.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Schulman, Joseph H.
Karr, Lawrence J.
Abrégé
An object locator system utilizes a microtransponder (12) that is used in association with an object to be located. A remote locator (10) transmits an encoded signal in which is embedded an identification code associated with the object to be located. The microtransponder (12) receives the encoded transmitted signal and processes such signal utilizing fast fourier transform techniques. The microtransponder (12) correlates the transformed received signal with a fast fourier transformed version of an identification code associated with the microtransponder (12) and upon detection of a correlation, transmits an acknowledgement signal to the remote locator (10). The remote locator (10) determines the distance to the microtransponder (12) based upon the round trip time from transmission of the coded signal to the microtransponder (12) to the receipt of the acknowledgement signal.
B60R 25/00 - VÉHICULES, ÉQUIPEMENTS OU PARTIES DE VÉHICULES, NON PRÉVUS AILLEURS Équipements ou systèmes pour interdire ou signaler l’usage non autorisé ou le vol de véhicules
G05B 23/00 - Test ou contrôle des systèmes de commande ou de leurs éléments
G06F 7/00 - Procédés ou dispositions pour le traitement de données en agissant sur l'ordre ou le contenu des données maniées
G06F 7/04 - Contrôle d'égalité, c. à d. pour valeurs égales ou non
G08B 29/00 - Vérification ou contrôle des systèmes de signalisation ou d'alarme; Prévention ou correction d'erreurs de fonctionnement, p.ex. empêchant le déclenchement non autorisé
G08C 19/00 - Systèmes de transmission de signaux électriques
H04B 1/00 - TRANSMISSION - Détails des systèmes de transmission non caractérisés par le milieu utilisé pour la transmission
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Karr, Lawrence, J.
Abrégé
The device includes a first antenna (ANT1) that is coupled to a first transmit/receive switch (SW1), which is in turn coupled to a first transmitter (TXTR1) and a first receiver (RCVR1) in response to a first control signal (TX1/RX1N). A second receiver (RCVR2) is coupled to a second antenna (ANT2) via a band-limiting filter (BPF2). Similarly, a third receiver (RCVR3) is coupled to a third antenna (ANT3) via a band-limiting filter (BPF3).
G01S 13/76 - Systèmes utilisant la reradiation d'ondes radio, p.ex. du type radar secondaire; Systèmes analogues dans lesquels des signaux de type pulsé sont transmis
G01S 13/78 - Systèmes utilisant la reradiation d'ondes radio, p.ex. du type radar secondaire; Systèmes analogues dans lesquels des signaux de type pulsé sont transmis effectuant la discrimination entre différents types de cibles, p.ex. radar pour l'identification ami–ennemi
G01S 13/00 - Systèmes utilisant la réflexion ou la reradiation d'ondes radio, p.ex. systèmes radar; Systèmes analogues utilisant la réflexion ou la reradiation d'ondes dont la nature ou la longueur d'onde sont sans importance ou non spécifiées
61.
NEUROMUSCULAR STIMULATION TO AVOID PULMONARY EMBOLISMS
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Mandell, Lee, J.
Abrégé
A system and method that provide a prophylactic treatment to a person, e.g., a patient, to avoid the occurrence of pulmonary embolisms by the system providing neuromuscular stimulation to a person’s lower extremities, e.g., the person’s legs, when the system senses that a person has been immobile for an extended period of time. An implantable neuromuscular pacer, such as that described in U.S. Pat. Nos. 5,193,539; 5,193,540; 6,164,284; 6,185,452; 6,208,894; 6,315,721; 6,564,807; and their progeny, may be used to provide to selectively provide such stimulation. Preferably, such a device may be battery powered so that it can operate independent of an external apparatus. In particular, systems and devices of the present invention preferably additionally include an activity monitor, e.g., an accelerometer or the like, that disables or limits stimulation to pronged time periods in which there is limited activity.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventeur(s)
Mandell, Lee, J.
Abrégé
A system and method that provides adjustable diaphragmatic pacing to a patient having an associated neurological deficit with adjustments occurring automatically in response to the patient’s physiological need. In a first implementation, physiological need is determined according to the patient’s activity level, e.g., as determined by the patient’s motion as detected by one or more accelerometers. In a second implementation, physiological need is determined by an oximeter measuring the current oxygen level of the patient’s blood. In a third implementation, physiological need is determined by a combination of the first and second implementation according to sensed motion and sensed oxygen level. Preferably, systems of the present invention are implantable and powered by rechargeable batteries and may be integrated with a system of implantable devices that restores motor functions to an injured patient and this restoration then requires an adjustable respiration rate in response to the patient’s restored movements.