Abrégé

The present invention concerns a method of manoeuvring a vertical take-off and landing, unmanned aerial drone (100) comprising at least an aerodynamic surface (101), wherein, during a flight of the drone, the aerodynamic surface generates lift and/or drag and an aerodynamic surface area is dynamically varied to compensate for adverse wind currents and/or to use said wind currents and/or to use an effective airspeed velocity as an assistance in manoeuvring the drone flight, said aerodynamic surface area variations allowing to reduce an energy consumption of the drone.

Classes IPC  ?

• B64C 3/54 - Variation de la surface alaire
• B64U 10/20 - Aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
• B64U 30/12 - Ailes variables ou détachables, p. ex. ailes à flèche réglable

Abrégé

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection.

Classes IPC  ?

• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

A method for aggregating digital signatures comprises the following steps carried out by a signature aggregator: receiving first data packages from signers, each first data package comprising a signer identifier, a payload, and a payload signature; verifying the payload signatures to determine whether or not the payloads are correctly signed; bundling correctly signed payloads into a batch; obtaining a batch digest, and proofs of inclusion of the payloads in the batch; sending second data packages comprising the batch digest and a respective proof of inclusion to the signers, the respective proof of inclusion proving that the payload of the respective signer is included in the batch; receiving third data packages from the signers, each third data package comprising the signer identifier, and a respective batch digest signature; verifying the batch digest signatures to determine whether or not the batch digests are correctly signed; aggregating correctly signed batch digest signatures to obtain an aggregated batch digest signature; and including the aggregated batch digest signature in the batch. The payload and batch digest signatures may be obtained by using different secret keys of the respective signer.

Classes IPC  ?

• G06F 21/64 - Protection de l’intégrité des données, p.ex. par sommes de contrôle, certificats ou signatures
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades.

Classes IPC  ?

• A61K 38/20 - Interleukines
• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so called old mRNA and such differences compared to control cell assays. The invention is applicable for screening in particular candidate ligand molecules such as antibodies for an effect on target cells, and thereby provides new strategies for the identification of therapeutically active compounds.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes

Abrégé

244.

Classes IPC  ?

• C10L 3/06 - Gaz naturel; Gaz naturel de synthèse obtenu par des procédés non prévus dans , ou
• C10L 3/08 - Production de gaz naturel de synthèse
• C10L 3/10 - Post-traitement de gaz naturel ou de gaz naturel de synthèse
• F17D 1/04 - Systèmes de canalisation pour gaz ou vapeurs pour la distribution du gaz

Abrégé

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property and configured to cover a molar tooth, and an internally exposed intermediate region defined by a third material property and configured to be located between the occlusional cushioning region and the impact protective region, wherein said first, second and third material properties are different. A corresponding method of fabricating a mouthguard is also described.

Classes IPC  ?

• A63B 71/08 - Moyens protecteurs du corps pour joueurs ou sportifs
• B33Y 10/00 - Procédés de fabrication additive

Abrégé

A water permeation sensor suitable for monitoring and quantitatively assessing ultra-low permeability of thin film encapsulations engineered for bioelectronic microdevices, its fabrication as well as device comprising the same are disclosed herein.

Classes IPC  ?

• A61B 5/263 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/266 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des électrolytes, gels ou pâtes conducteurs

Abrégé

[0054] Methods are provided for estimating key reliably and accurately predicting cardiac output using a limited set of non-invasively monitored physiologic inputs, and a calibrated one- dimensional arterial tree model, a database of synthetic data generated from such a model, and an artificial intelligence module. Systems for estimating CO based on non-invasively measured physiologic inputs also are provided that may be implemented without the need for extensive real-time computing resources.

Classes IPC  ?

• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
• A61B 5/029 - Mesure du débit de sang à la sortie du cœur, p.ex. volume éjecté par minute

Abrégé

Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treating aneurysms in challenging anatomy such as the thoracic aorta. The compliant vascular grafts preferably have an outer frame layer and an inner graft layer with a plurality of pleats to permit expansion.

Classes IPC  ?

• A61F 2/06 - Vaisseaux sanguins
• A61F 2/07 - Endoprothèses déployables couvertes

Abrégé

Herein described are diaryl ether compounds having the structure (I) as well as a method for their manufacture from lignin.

Classes IPC  ?

• C07C 47/575 - Composés comportant des groupes —CHO liés à des atomes de carbone de cycles aromatiques à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
• C07C 69/92 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons d'acides hydroxycarboxyliques monocycliques dont les groupes hydroxyle et les groupes carboxyle sont liés à des atomes de carbone d'un cycle aromatique à six chaînons avec des groupes hydroxyle éthérifiés

Abrégé

Electrolyser including a reactor (2) comprising a housing (4), fluidic channels (6a, 6b, 6c) within the housing, and electrodes (16a, 16c) comprising an anode (16a) and a cathode (16c). The fluidic channels include an inter-electrode channel (6b) arranged between the anode (16a) and cathode (16c) and connected to an anode channel inlet (8a) for injection of an electrolyte into the inter-electrode channel (6b), a cathode channel (6c) separated from the inter-electrode channel (6b) by a porous cathode side wall (14c) comprising a plurality of canals (20), and an anode channel (6a) separated from the inter-electrode channel (6b) by a porous anode side wall (14a) comprising a plurality of canals (20). Each canal has a tapered shape such that an inlet surface area (Si) of the canal is greater than an outlet surface area (So) of the canal, the inlet surface area being on a side of the porous walls bounding the inter-electrode channel (6b).

Classes IPC  ?

• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 9/21 - Cellules comprenant des électrodes fixes de dimensions stables; Assemblages de leurs éléments de structure avec des diaphragmes avec plusieurs diaphragmes
• C25B 11/03 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées
• C25B 13/02 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Éléments d'espacement caractérisés par la configuration ou la forme

Abrégé

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions or methods using IL-4, a fragment or variant thereof, fused to a moiety, to increase the efficacy of an anti-cancer immunotherapy or an autoimmune therapy.

Classes IPC  ?

• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61K 38/20 - Interleukines
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament
• C07K 14/54 - Interleukines (IL)

Abrégé

Nanopore-based scanning system including a probe structure comprising a nanopore; suction means configured to draw an end of a (bio)molecule inside the nanopore and inside the probe structure, single or multiple times; and displacement means configured to mechanically displace the probe structure and the nanopore relative to the one (bio)molecule along a direction following a direction of extension of the (bio)molecule while the (bio)molecule is located inside the nanopore and inside the probe structure, or configured to mechanically displace at least one support holding the (bio)molecule relative to the nanopore along a direction following a direction of extension of the (bio)molecule while holding the at least one support and while the (bio)molecule is located inside the nanopore.

Classes IPC  ?

• B01L 3/02 - Burettes; Pipettes
• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
• C12Q 1/6869 - Méthodes de séquençage
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01Q 60/44 - Microscopie à conductance ionique à balayage SICM [Scanning Ion-Conductance Microscopy] ou appareils à cet effet, p.ex. sondes SICM

Abrégé

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition in a subject by administering an engineered progenitor cell or an engineered cell differentiated from an engineered progenitor cell of the present disclosure.

Classes IPC  ?

• C12N 5/0784 - Cellules dendritiques; Leurs progéniteurs

Abrégé

The present invention concerns an electrolysis system for high temperature electrolysis including a plurality of flow-based electrolysis units configured to receive an electrolyte solution and to perform electrolysis to provide a first output gas and a second output gas, the plurality of flow-based electrolysis units being membrane-less electrolysis units; at least one heating mechanism or means for heating the electrolyte solution to undergo electrolysis; a first gas separator and a second gas separator configured to remove the first output gas and the second output gas from the electrolyte solution; and an encasement or a cell enclosing the plurality of flow-based electrolysis units, the encasement or the cell being configured to support a pressure of the electrolyte solution permitting to increase a boiling point of the electrolyte solution to a temperature between 96°C and 350°C.

Classes IPC  ?

• C25B 1/042 - Hydrogène ou oxygène par électrolyse de l'eau par électrolyse de la vapeur
• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 9/60 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Éléments de structure des cellules; Assemblages d'éléments de structure, p.ex. assemblages d'électrode-diaphragme; Caractéristiques des cellules relatives aux procédés Éléments de structure des cellules
• C25B 9/67 - Moyens de chauffage ou de refroidissement
• C25B 9/70 - Assemblages comprenant plusieurs cellules
• C25B 11/031 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées Électrodes poreuses
• C25B 11/046 - Alliages
• C25B 15/025 - Paramètres de l’électrolyte
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes

Abrégé

de novode novo bottom-up assembly and rational design of allosteric biosensors with programmable input-output behaviors that respond to soluble factors selectively enriched in tumors and trigger co-stimulation and cytokine signals. The disclosed method of effective mechanical coupling and biosensor signaling potency correlates with anti-tumor function. This disclosure provides synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.

Classes IPC  ?

• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance
• C07K 14/725 - Récepteurs de lymphocytes-T
• A61P 35/00 - Agents anticancéreux

Abrégé

The present relates to a system for automated cell culture, the system comprising an inflow module, a cell culture plate and an outflow module, said inflow module being in fluid connection with the outflow module via the cell culture plate, the inflow module further comprising a microfluidic distribution module in fluid connection with the inflow module, the microfluidic distribution module being configured for controlling the distribution of a fluid flow from the inflow module to the cell culture plate, characterized in that the cell culture plate comprises at least one culture well configured for cell culture, and in that the system further comprises an adaptor coupled to the microfluidic distribution module, the adaptor being reversibly connectable to the cell culture plate so that when the adaptor is connected to the cell culture plate, the distribution of the fluid flow to said culture well is controlled by the microfluidic distribution module.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

The present invention relates to variants of the GAIN domain (G-protein-coupled receptor autoproteolysis-inducing domain) of an adhesion G protein-coupled receptor (ADGRG), such as a GAIN domain variant comprising or consisting of the amino acid sequence of the GAIN domain of ADGRG1 (Adhesion G Protein-Coupled Receptor G1) of SEQ ID NO: 1, wherein (i) one of amino acid positions (3) to (5), preferably amino acid position (4) and one of amino acid positions (47) to (49), preferably amino acid position (48) of SEQ ID NO: 1 are replaced by cysteines, (ii) one of amino acid positions (35) to (37), preferably amino acid position (36) and one of amino acid positions 180 to (182), preferably amino acid position (181) of SEQ ID NO: 1 are replaced by cysteines, (iii) one of amino acid positions (19) to (21), preferably amino acid position 20 and one of amino acid positions (124) to (126), preferably amino acid position (125) of SEQ ID NO: 1 are replaced by cysteines, (iv) one of amino acid positions (56) to (58), preferably amino acid position (57) and one of amino acid positions (65) to (67), preferably amino acid position (66) of SEQ ID NO: 1 are replaced by cysteines, (v) one of amino acid positions (16) to (18), preferably amino acid position (17) and one of amino acid positions (60) to (62), preferably amino acid position (61) of SEQ ID NO: 1 are replaced by cysteines, (vi) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine and the amino acid position at position (181) is replaced by arginine, (vii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine and the amino acid position at position (181) is replaced by arginine, (viii) the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, and the amino acid position at position (181) is replaced by arginine, (ix) the amino acid position at position (33) is replaced by tryptophane, the amino acid position at position (40) is replaced by glutamic acid, the amino acid position at position (43) is replaced by leucine, the amino acid position at position (135) is replaced by arginine, the amino acid position at position (146) is replaced by tyrosine, the amino acid position at position (178) is replaced by tyrosine, the amino acid position at position (181) is replaced by arginine, the amino acid position at position (184) is replaced by glycine, the amino acid position at position (186) is replaced by glutamine, and the amino acid position at position (187) is replaced by glycine, (x) the amino acid position at position (174) is replaced by isoleucine, (xi) the amino acid position at position (218) is replaced by alanine, or (xii) at least two of (i) to (xi) apply; or (B) comprising or consisting of an amino acid sequence sharing at least 80% sequence identity with the variant of (A), provided that the cysteines as defined in (A), item (i), (ii), (iii), (iv) and/or (v), or the amino acid replacement(s) as defined in (A), item (vi), (vii), (viii), (ix), (x) and/or (xi), or the cysteines and/or the amino acid replacement(s) as defined in (A), item (xii) are retained.

Classes IPC  ?

• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype

Abrégé

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployable by eversion, said electrode structure (300) comprising: i) an elastic polymeric support (301) operatively connected to the reservoir's inlet (101) through a first end (302) and to the mechanical support (200) at a second end (303), and ii) at least one conductive track (400) disposed on a surface (S) of said elastic polymeric support (301).

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

It is disclosed a method for manufacturing an electrically conductive metal trace (1) comprising depositing metal micro or nano particles (2) in or on a substrate (3); removing an oxide layer (4) around the particles; sintering the particles after oxide layer removal to form the electrically conductive metal trace (1). The method is characterized in that the step of removing the oxide layer is an electrochemical process wherein the metal micro or nano particles are contacted by a reducing agent (5), and the step of sintering is heat sintering induced by light (6). The method is particularly suitable for manufacturing a transient electrically conductive metal trace.

Classes IPC  ?

• H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
• H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur

Abrégé

ncii i = 1,2..., n,pii i = 1,2..., nSASmαjj j = 1,2,..., mL = [Rj,ij,i ]Rj,ij,i αjj pii Sn Vkiki tkk k = 1,2,...,S,V = [Vk,ik,i ]i = 1,2,...,nVkiki cii pii tkk rPk,hk,h tkk k = 1,2,..., sPk,hk,h h= 1,2,...,rPkk htkk D = [dh,ih,i ], DV = [Vk,ik,i ]P = [Pk,hk,h ]dh,ih,i hPk,hk,h iVk,ik,i tkk ΦDBFDBF= [φh,jh,j ], φh,jh,j hαjj Shαjj φh,jh,j ΦDBFDBF.

Classes IPC  ?

• A61B 5/294 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
• A61B 5/311 - Circuits d’entrée à cet effet spécialement adaptés à des utilisations particulières pour l’étude de la conduction nerveuse [NCS]
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least one of the layers, that is not a top layer, constituting an information layer (9i) configured to be modified locally by energy from an electromagnetic beam (7) having a specific beam wavelength and a propagation direction (Z) transverse to the layers. The stacked plurality of layers include an aperiodic layer arrangement including at least three stacked adjacent layers having different thicknesses with respect to each other.

Classes IPC  ?

• G11B 7/24038 - Couches d’enregistrement multiples stratifiées
• G11B 7/24067 - Association de plusieurs couches inter-corrélées de manière spécifique
• G11B 7/242 - Supports d’enregistrement caractérisés par le choix du matériau des couches d'enregistrement

Abrégé

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation (DBS) System for providing Deep Brain Stimulation to brain tissue of a subject (P), - at least one control unit, configured and adapted to provide stimulation data, - at least one stimulation unit (12), operatively connected to the at least one control unit, the at least one stimulation unit (12) being configured and adapted to deliver epidural electrical stimulation (EES) to the dorsal side of the spinal cord (S) of said subject (P), and - at least one implantable pulse generator (IPG) (13), wherein the at least one stimulation unit (12) includes one or more electrodes (14) configured to be implanted epidurally, the one or more electrodes (14) being operatively connected to the at least one IPG (13).

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

The present invention concerns methods and devices for cultivating coenocytic algae and for producing cellulose, in particular microfibrillated cellulose (MFC). In one embodiment, the algae are grown on a solid substrate immersed in liquid culture medium. The solid substrate preferably comprises a carbonite mineral. The invention also concerns a method for producing spores of said coenocytic algae and a device comprising two separate containers, a first container for growing said algae and a second container for growing larger algae and inducing the generation of spores.

Classes IPC  ?

• A01G 33/00 - Culture des algues
• A01H 4/00 - Reproduction de plantes par des techniques de culture de tissus
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12N 1/12 - Algues unicellulaires; Leurs milieux de culture
• C12P 19/04 - Polysaccharides, c. à d. composés contenant plus de cinq radicaux saccharide reliés entre eux par des liaisons glucosidiques

Abrégé

The present invention concerns a method for determining an estimated value for different parameters on the basis of one or more acquired signals obtained during a Magnetic Resonance Fingerprinting measurement. The method includes using a correction model and/or an iterative approach for improving the accuracy of the obtained estimated values.

Classes IPC  ?

• G01R 33/56 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne
• G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar

Abrégé

50607070270702707027070270270270237012011011021061231011031061011011010)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

Classes IPC  ?

• C07H 9/04 - Acétals cycliques
• C09K 23/00 - Utilisation de substances comme agents émulsifiants, humidifiants, dispersants ou générateurs de mousse
• C11D 1/66 - Composés non ioniques
• C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide

Abrégé

The present invention provides a method for preparing a sequencing library from a ribonucleic acid (RNA) sample.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

in silicode novo in silico in silico in silico based on the peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) of (e) an ensemble of peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) for which the lowest interface energy peptide-protein molecular complexes can be modelled, thereby obtaining engineered peptides and/or proteins being capable of forming a molecular complex with engineered binding characteristics.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire

Abrégé

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

Classes IPC  ?

• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

The present invention concerns a waveguide amplifier comprising: - at least one embedding cladding material or layer, and - at least one rare-earth ion implanted silicon nitride material or layer embedded in the at least one embedding cladding material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core enclosed by the at least one embedding cladding material or layer.

Classes IPC  ?

• H01S 3/063 - Lasers à guide d'ondes, p.ex. amplificateurs laser
• H01S 3/16 - Matériaux solides
• H01S 5/40 - Agencement de plusieurs lasers à semi-conducteurs, non prévu dans les groupes
• H01S 3/0941 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p.ex. par une diode laser
• H01S 3/094 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente

Abrégé

M. smithiiM. smithiiM. smithiiM. smithii M. smithii M. smithii for promoting immune system homeostasis and intestinal health and for treating disorders associated with aberrant microbiota and/or archaea-deficiency.

Classes IPC  ?

• A61K 35/741 - Probiotiques
• C07K 16/12 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• G01N 33/577 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet faisant intervenir des anticorps monoclonaux

Abrégé

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

Classes IPC  ?

• A61K 35/14 - Sang; Sang artificiel
• A61K 38/45 - Transférases (2)
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/09 - Cellules tumorales

Abrégé

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/304 - Circuits de commutation

Abrégé

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for dimensionality reduction of time-series using contrastive learning. A method can include receiving multidimensional input time series data that includes data from a session or sessions that span time, selecting positive samples and negative samples from the multidimensional input time series data for respective reference samples from the multidimensional input time series data, wherein the positive samples and negative samples are each selected with a respective predetermined distribution across the time of the session or sessions of the multidimensional input time series, and mapping the reference samples, the positive samples, and negative samples into a common embedding space.

Classes IPC  ?

• G06N 3/0895 - Apprentissage faiblement supervisé, p.ex. apprentissage semi-supervisé ou auto-supervisé
• G06N 3/045 - Combinaisons de réseaux
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or bacterial infections or coinfection by virus and bacteria.

Classes IPC  ?

• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07D 405/00 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle
• C07D 409/00 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle

Abrégé

A force-feedback surface that creates and modulates distinctive profile and stiffnessto interact with a user in contact thereto, the surface being functionally independentto be used as a single module but can be customized to extend the application indiverse fields by assembling in series, parallel, or any combinations to form amultimodular system.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée

Abrégé

The present invention concerns a method for producing at least one ferroelectric device or structure comprising the steps of providing at least one ferroelectric material or layer, or providing at least one ferroelectric material or layer to be patterned or structured; depositing at least one adhesion layer on a first side of the at least one ferroelectric material or layer; and depositing at least one diamond-like carbon layer or material on the at least one adhesion layer.

Classes IPC  ?

• G02F 1/00 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire
• G02B 6/136 - Circuits optiques intégrés caractérisés par le procédé de fabrication par gravure
• G02F 1/05 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr avec des propriétés ferro-électriques

Abrégé

1233)+n1233 are independently selected from a hydrocarbyl group containing 1-40 carbon atoms said hydrocarbyl group, if said hydrocarbyl group comprises 3 or more carbons, may be linear or branched; and W is an anion.

Classes IPC  ?

• H01L 51/42 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement en énergie électrique, soit comme dispositifs de commande de l'énergie électrique par ledit rayonnement

Abrégé

ssTRTRR).

Classes IPC  ?

• G01S 7/288 - Récepteurs cohérents
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• G01S 13/28 - Systèmes pour mesurer la distance uniquement utilisant la transmission de trains discontinus d'ondes modulées par impulsions dans lesquels les impulsions émises utilisent une onde porteuse modulée en fréquence ou en phase avec compression dans le temps des impulsions reçues
• G01S 17/36 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées avec comparaison en phase entre le signal reçu et le signal transmis au même moment
• G01S 17/86 - Combinaisons de systèmes lidar avec des systèmes autres que lidar, radar ou sonar, p.ex. avec des goniomètres

Abrégé

Electronic metadevice comprising a conductive channel; a metal layer superposed on the conductive channel; and a barrier layer located between the metal layer and the conductive channel. The metal layer includes at least one recess extending through the metal layer to define at least one metallic metastructure comprising at least one first metal layer portion adjacent to at least one second metal layer portion. The recess extends through the metal layer to define a micro-structured or a nano-structured first metal layer portion comprising at least one first metallic extension or finger extending away from a first support of the first metal layer portion towards the second metal layer portion; and a micro-structured or a nano-structured at least one second metal layer portion comprising at least one second metallic extension or finger extending away from a second support of the second metal layer portion towards the first metal layer portion.

Classes IPC  ?

• H01L 29/86 - Types de dispositifs semi-conducteurs commandés uniquement par la variation du courant électrique fourni, ou uniquement par la tension électrique appliquée, à l'une ou plusieurs des électrodes transportant le courant à redresser, amplifier, faire osciller, ou commuter
• H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
• H01L 29/417 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative transportant le courant à redresser, à amplifier ou à commuter
• H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
• H01L 29/24 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des matériaux semi-conducteurs inorganiques non couverts par les groupes , ,  ou

Abrégé

A micro- or nanostructured optical element (1) is proposed comprising: a membrane (3) with an array of holes (5), the membrane (3) comprising a membrane light wave facing surface; an array of pillars (7) sized and shaped such that a respective pillar (7) is configured to be at least partially received in a respective hole (5), the respective pillar (7) defining a central pillar axis, and comprising a pillar light wave facing surface; a support (9) configured to support the pillars (7); and an actuation mechanism configured to selectively generate a relative displacement between the membrane (3) and the pillars (7) along the central pillar axes to thereby define a first optical element reflectance state, where the membrane (3) is in an elevated position with respect to the support (9), and a second, different optical element reflectance state, where the membrane (3) is in a lowered position with respect to the support (9) such that the respective pillar (7) extends through the respective hole (5). In the first optical element reflectance state, the membrane light wave facing surface is substantially flush with the pillar light wave facing surfaces, or the membrane light wave facing surface is placed beyond the pillar light wave facing surfaces.

Classes IPC  ?

• G02B 26/00 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables

Abrégé

A hollow variable stiffness thread including a flexible inner tube, a conductive shape memory polymer (CSMP) layer arranged around the inner tube forming a variable stiffness zone, a flexible encapsulation layer arranged around the CSMP layer, and a first electrode and a second electrode, at least a portion of the first and the second electrodes being in contact with the CSMP layer.

Classes IPC  ?

• A61B 18/14 - Sondes ou électrodes à cet effet
• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/00 - Cathéters; Sondes creuses
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets

Abrégé

Compounds, compositions and methods that can be used for the treatment of viral diseases are provided.

Classes IPC  ?

• A61P 31/12 - Antiviraux
• C07K 16/08 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
• A61P 37/02 - Immunomodulateurs
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

A smart wearable (SW) for collecting data on an integrity of a joint of a wearer, the wearable including a first frame (1) configured to be attached in proximity of the joint of the wearer, the frame (1) including an elastic sensor frame (3) having an open cavity (21) configured to be attached to an area of interest of the joint, a kinematic sensor device (19) configured to measure kinematics of the joint, and acoustic sensor device (13) arranged in the cavity (21) configured to capture airborne acoustic emissions from the area of interest, and a data processor device (18) configured to receive and record data from the kinematic sensor device (19) and from the acoustic sensor device (13).

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

A photonic assembly, a laser setup comprising said photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using said laser setup are disclosed. The photonic assembly (1) comprises an active photonic chip (10), a photonic modulator chip (2) comprising a photonic circuit arrangement, and a tuning arrangement comprising a modulation element (33) having a thickness of 10 micrometers or less. The active photonic chip (10) and the photonic modulator chip (2) are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip (10). The modulation element (33) is arranged such, that an actuation of the modulation element (33) tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

Classes IPC  ?

• H01S 3/107 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p.ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs électro-optiques, p.ex. produisant un effet Pockels ou Kerr
• G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p.ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
• H01S 3/11 - Blocage de modes; Commutation-Q; Autres techniques d'impulsions géantes, p.ex. vidange de cavité
• H01S 5/14 - Lasers à cavité externe

Abrégé

The invention concerns a single-particle inductively-coupled plasma (ICP) mass spectrometry particle sizing and counting method comprising providing or receiving an intensity-versus-counts histogram of particles detected using an ICP mass spectrometer, the intensity representing particle detection and the count representing particle detection frequency; providing or receiving mass flux calibration data or calibration curve data relating a value of the intensity measurement or data of the ICP mass spectrometer to a mass of material detected per acquisition interval or dwell time; determining a particle mass of the particles detected using the mass flux calibration data or the at least one mass flux calibration curve data, determining a particle volume of the detected particles using the determined particle mass, and determining a particle size of the particles detected using the determined particle volume of the particles detected and a determined or attributed geometry or shape of the detected particles.

Classes IPC  ?

• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G01N 15/10 - Recherche de particules individuelles
• G01N 15/00 - Recherche de caractéristiques de particules; Recherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/10 - Sources d'ions; Canons à ions

Abrégé

Disclosed herein is a method of operating a microfluidic system, a microfluidic system for manipulating sample objects, and a control system for operating a microfluidic system. The method according to the invention is for operating a microfluidic system that comprises a manipulation zone for manipulating sample objects flowing through the manipulation zone, a first detection zone arranged upstream of or in the manipulation zone and a second detection zone arranged upstream of, in or downstream of the manipulation zone. A first count is determined that characterizes a number of sample objects flowing through the first detection zone. Sample objects are manipulated in the manipulation zone. A second count is determined that characterizes a number of sample objects flowing through the second detection zone. One or more manipulation parameters for manipulating the sample objects in the manipulation zone are adjusted based on the first count and the second count.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 15/14 - Recherche par des moyens électro-optiques
• G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p.ex. analyse à injection dans un écoulement
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid communication with the loading channel, wherein the at least one auxiliary channel is so dimensioned such that a hydraulic resistance in the at least one auxiliary channel is higher than a hydraulic resistance in the loading channel; a test area (150) defined along the loading channel at a position between the loading channel and the at least one auxiliary channel; a first medium reservoir (110) in fluid communication with a first side of the test area; and a second medium reservoir (120) in fluid communication with a second side of the test area, the second side being different from the first side.

Classes IPC  ?

• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse

Abrégé

iiooiii of the inlet channel (31) satisfy a geometrical condition of formula (I), said z > 1.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The invention relates to a Method for operating a frequency agile tunable self-injection locking laser system being formed by a laser device coupled to at least one optical resonator, wherein a diode current of a laser diode of the laser device is controllable and wherein the optical resonator is controllable by controlling a piezo or an electro-optical actuator configured to apply a variation of the refractive index of the resonator material through mechanical stress or an electric displacement field, respectively, at least partially onto the at least one optical resonator depending on an actuation voltage, inducing a change in the effective optical path length of the at least one optical resonator, comprising the steps of: - Selecting a self-injection locking range among a plurality of self-injection locking ranges by varying a laser diode current and monitoring self-injection locking ranges, wherein self-injection locking ranges corresponding to current ranges in which self-injection locking occurs, wherein the self-injection locking corresponds to an optical feedback phase for back-reflected light from the optical resonator into the laser device, - setting the diode current from the current range of the selected self-injection locking mode; - determining a maximum tuning range of the actuation voltage in which self-injection locking is maintained; - operating the laser system with actuation voltages in a range depending on the determined tuning range.

Classes IPC  ?

• H01S 5/065 - Accrochage de modes; Suppression de modes; Sélection de modes
• H01S 5/00 - Lasers à semi-conducteurs
• H01S 5/062 - Dispositions pour commander les paramètres de sortie du laser, p.ex. en agissant sur le milieu actif en faisant varier le potentiel des électrodes
• H01S 5/02325 - Composants intégrés mécaniquement aux éléments de montage ou aux micro-bancs optiques
• H01S 5/068 - Stabilisation des paramètres de sortie du laser
• H01S 5/06 - Dispositions pour commander les paramètres de sortie du laser, p.ex. en agissant sur le milieu actif

Abrégé

posmidnegneg); - a nonlinear inductor (27) serially coupled between the output of the voltage selector (26); - a gate control unit (23) configured to control the voltage selector (26) to control switching of the gate commutated thyristor (21) in its turn-on state comprising a turn-on pulse generation, a positive-gate-voltage backporch operation, a negative-gate-voltage backporch operation and a retrigger pulse generation; wherein the nonlinear inductor (27) has a nonlinearity to have a high inductance during any of the backporch operations and to have a low inductance during the turn-on pulse generation and retrigger pulse generation.

Classes IPC  ?

• H03K 17/80 - Commutation ou ouverture de porte électronique, c. à d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs magnétiques ou diélectriques non linéaires
• H03K 17/04 - Modifications pour accélérer la commutation
• H03K 17/0412 - Modifications pour accélérer la commutation sans réaction du circuit de sortie vers le circuit de commande par des dispositions prises dans le circuit de commande
• H03K 17/13 - Modifications pour commuter lors du passage par zéro
• H02M 1/08 - Circuits spécialement adaptés à la production d'une tension de commande pour les dispositifs à semi-conducteurs incorporés dans des convertisseurs statiques
• H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation
• H02M 3/00 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu

Abrégé

The present invention relates to a polyaromatic polymer that comprises multifunctional aromatic moieties MA, cationic groups CG and bifunctional aromatic moieties BA, wherein one or more CG and one or more BA form a linear unit L, and MA is connected to 3 to 6 linear units L. MA, CG and BA are defined as described in the specification. Furthermore, the present invention relates to a neutral precursor of the polyaromatic polymer and to an anion exchange membrane that comprises a polyaromatic polymer according to the invention.

Classes IPC  ?

• C08G 10/00 - Polymères de condensation obtenus uniquement à partir d'aldéhydes ou de cétones avec des hydrocarbures aromatiques ou avec leurs dérivés halogénés
• C08J 5/22 - Bandes, membranes ou diaphragmes
• B01J 41/13 - Composés macromoléculaires obtenus autrement que par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
• B01D 71/72 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
• B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p.ex. introduits par un post-traitement chimique

Abrégé

The invention relates to substituted cyclodextrin (CD) compounds having C9 to C25 optionally substituted alkyl-based linker groups, which irreversibly inhibit viruses and are useful in the treatment of viral infections. While the compounds of the invention show virus inhibition in the nanomolar range they show no in-vitro toxicity in the same range of concentration.

Classes IPC  ?

• A61K 31/724 - Cyclodextrines
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• C08B 37/16 - Cyclodextrine; Ses dérivés

Abrégé

A floating platform for a wind turbine comprising a vertically arranged support; a toroidal body arranged horizontally and coaxially around said support; a plurality of connection elements which extends radially to connect the support to the toroidal body, wherein at least one of the support, the toroidal body and the connection elements is made of a natural fibre reinforced composite material and all elements can be adhesively bonded to each other; a system using said platform and combining wind-powered hydrolysis and green hydrogen production and storage is also described.

Classes IPC  ?

• B63B 1/04 - Caractéristiques hydrodynamiques ou hydrostatiques des coques ou des ailes portantes tirant la portance principalement du déplacement liquide à coque simple
• B63B 5/24 - Coques caractérisées par leur construction en un matériau non métallique faites principalement de plastiques
• B63B 21/50 - Dispositifs d'ancrage pour navires spéciaux, p.ex. pour plates-formes flottantes de forage ou dragues

Abrégé

The present invention concerns a system for phenotypical profiling of at least one object and deterministic nanoliter-droplet encapsulation, comprising sample supplying means, buffer supplying means; a microfluidic chip comprising an encapsulation area or structure in which the object is encapsulated with a quantity of the reaction buffer by the droplet; detection means configured to detect the passage of the object through the first imaging chamber; at least one valve configured to stop the flow of the sample buffer when the detection means detect passage of the object through the first imaging chamber; phenotypical assessing means configured to assess the phenotype of the object when the flow of the sample buffer is stopped by the valve and the object is at an object stopping site; a droplet deposition means configured to deposit the droplet in a well or in a well of a multi-well plate and comprising an outlet capillary.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• G01N 15/00 - Recherche de caractéristiques de particules; Recherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux

Abrégé

The present invention relates generally to the field of nucleic acid sequencing and provides oligonucleotide molecules and barcodes contained therein. These oligonucleotide molecules and barcodes molecules are useful in sequencing to identify and resolve errors.

Classes IPC  ?

• C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN

Abrégé

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of adoptive T cell transfer therapy for treating cancer, in particular sold tumors. More specifically, the present invention relates to immune cells comprising one or more recombinant constructs, wherein at least one recombinant construct encodes an interleukin-10, a fragment or a variant thereof.

Classes IPC  ?

• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p.ex. cellules transformées par des virus
• A61K 35/14 - Sang; Sang artificiel
• A61P 35/00 - Agents anticancéreux

Abrégé

12345671234566) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q; (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R; and (Y) is a Michael acceptor.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 14/81 - Inhibiteurs de protéase
• C12N 9/50 - Protéinases

Abrégé

The present invention relates to a method for operating a resonant power converter (1) having a primary stage (2) and a secondary stage (3) at least one of which is actively operated and includes a half-bridge or full-bridge inverter (21) having a pull-up switching device (S1) coupled in parallel with a pull-up antiparallel diode (D1) and a pull-down switching device (S2) coupled in parallel with a pull-down antiparallel diode (D2), comprising the steps of: - alternately turning-off and turning on the pull-up (S1) and pull-down switching devices (S2) according to a periodic switching scheme, wherein after turning-off one of the switching devices (S1, S2) the complementary switching device (S2, S1) is respectively turned on after a delay time; - initiating an error handling, if after turning-off of one of the switching devices (S1, S2) a non-conductance state of the antiparallel diode (D1, D2) of the complementary switching device (S2, S1) has been determined.

Classes IPC  ?

• H02M 3/00 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu
• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H02M 1/08 - Circuits spécialement adaptés à la production d'une tension de commande pour les dispositifs à semi-conducteurs incorporés dans des convertisseurs statiques
• H02M 1/38 - Moyens pour empêcher la conduction simultanée de commutateurs
• H02M 1/32 - Moyens pour protéger les convertisseurs autrement que par mise hors circuit automatique
• H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation

Abrégé

The present invention concerns a biological material pooling device for biological or biomolecule purification comprising a receptacle including a first orifice comprising ordefining a rectangular opening, the receptacle being configured to receive at least one liquid through the first orifice, a second orifice located opposite the first orifice; and at least one side wall extending between the first orifice and the second orifice. The at least one side wall extends between the first orifice and the second orifice to define a tapered cavity or a cavity of decreasing cross-sectional area between the first orifice and the second orifice to guide and remove the at least one liquid out of the biological material pooling device.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B67C 11/00 - Entonnoirs, p.ex. pour liquides

Abrégé

The invention relates to an integrated imaging system comprising: - an array of analog photomultiplier elements - a plurality of submodules, each submodule having a number of the photomultiplier elements; - a plurality of time-to-digital converters each associated and coupled with one of the submodules, wherein the plurality of time-to-digital converters are configured to provide a respective timing information.

Classes IPC  ?

• G01T 1/24 - Mesure de l'intensité de radiation avec des détecteurs à semi-conducteurs

Abrégé

A light spectrometer including a laser configured to provide for a laser pulse (12), a quantum dot (30), an objective (21) configured to focus the laser pulse (12) onto the quantum dot (30) such that a fluorescent light beam is emitted from the quantum dot (30), a blazed grating (40) arranged in a light path of the fluorescent light beam to generate a plurality of fluorescent light beams of different wavelengths, an imaging lens (26) configured to generate a plurality of images from the fluorescent light beams of different wavelengths, respectively, a single photon avalanche diode (SPAD) array (50) having a plurality of pixels arranged at the imaging plane of the images, a circuit interfaced with the SPAD array, the circuit configured to detect a first photon and a second photon of an entangled photon pair emitted by the fluorescent light beam of the quantum dot in response to the laser pulse (12), wherein each pixel of the SPAD array is arranged to be aligned with a respective one of the plurality of images.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

32332133131331323222 and more preferably with one or more F or Br.

Classes IPC  ?

• A61K 31/65 - Tétracyclines 
• A61P 31/12 - Antiviraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus

Abrégé

The invention relates to an expression vector encoding a DNA defence system comprising polypeptides derived from Vibrio cholerae, or equivalent functional variants or homologues, conferring resistance to the maintenance of extra-genomic DNA to a recipient bacterial cell. The invention further relates to methods for obtaining an isolated bacterium, or a bacterial population capable of eliminating extra-genomic DNA, or of protecting against phage infection, and an isolated bacterium, or a product comprising an expression vector according to the invention.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C07K 14/28 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Vibrionaceae (F)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

A molecular tool and a label-free method useful for detecting a target nucleic acid in a sample are disclosed, the molecular tool comprising a substrate comprising or consisting of an optical material; a first polymeric molecule, selected from nucleic acids or nucleic acid analogues, coupled with the substrate; and a second nucleic acid analogue coupled with the first polymeric molecule by means of nucleobase complementarity. The molecular tools and methods of the invention are configured for the optical detection of oligonucleotide binding events for diagnostic, point-of-care, drug screening applications using for instance a carbon nanotube optical signal. Circulating nucleic acids that have diagnostic and prognostic value for cancer, metabolic disease, organ rejection, foetal health and infectious disease can be therefore identified and characterized.

Classes IPC  ?

• C12Q 1/6816 - Tests d’hybridation caractérisés par les moyens de détection

Abrégé

The invention provides anti-SARS-CoV-2 antibodies and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection.

Classes IPC  ?

• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

A method, system, and computer-readable medium for identifying and creating a database of isomers and isobars of molecules including the steps of performing isomer or isobar separation on molecules to obtain separate isomeric or isobaric molecules, measuring mass-to-charge ratios (m/z) to obtain IR fingerprints of the separate isomeric or isobaric molecules, and storing first data on the mass-to-charge ratios (m/z) and/or the IR fingerprints of the separate isomeric or isobaric molecules to a database.

Classes IPC  ?

• G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques

Abrégé

The present invention relates to a device to carry out semiconductor based molecular diagnostics comprising a microfluidic chip carrier 1, an elastomer microfluidic module 2 and a CMOS chip 3, one surface of said microfluidic module facing and contacting one surface of said CMOS chip housing one or more field-effect transistor-based (FET-based) biosensors 3.1, the surface of said microfluidic module comprising one or more microfluidic flow channels 2.2.4, one or more analytical chambers 2.2.3 facing said one or more FET-based biosensors, one or more metal electrode lines 2.2.2 forming an electrode network patterned onto said surface of said microfluidic module, wherein a portion of the one or more electrode lines is non-planar, has a rounded or semi-circular shape and conformally coats the inside of the one or more microfluidic flow channels.

Classes IPC  ?

• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The present invention concerns a diamond device or structure comprising at least one supporting layer or material including at least one or a plurality of support structures inside the at least one supporting layer or material; a plurality of recesses defined by the at least one or the plurality of support structures; and at least one diamond micro-seed and a plurality of diamond nano-seeds located in each recess or in the plurality of recesses.

Classes IPC  ?

• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives

Abrégé

toolcritcrit) for which the beam (10) buckles.

Classes IPC  ?

• A61B 5/12 - Audiométrie
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci

Abrégé

Flexible surgical device with controllable stiffness The invention relates to a surgical device (10), comprising a tubular outer shaft (12,) and an inner element (14) having an elongated shape, the outer shaft comprising a distal (30a) and a proximal (30b) outer hinges, the inner element comprising an inner hinge (80), the surgical device having : a first and a second distal stiffnesses considered at the distal outer hinge; and a first and a second proximal stiffnesses considered at the proximal outer hinge; each of the second distal and proximal stiffnesses being superior to, respectively, the first distal and proximal stiffness; the inner element being able to move angularly and/or axially in the tubular outer shaft, between a first configuration and a second configuration, so that in the first configuration, the surgical device has the second distal stiffness and the first proximal stiffness.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
• A61B 10/04 - Instruments endoscopiques

Abrégé

The present invention relates to a method for preparing a library of peptides or an isolated peptide comprising (a) releasing one or more linear dithiol peptides carrying a sulfhydryl group in the N-terminal region of the one or more peptides and being immobilized via a disulfide bridge in the C-terminal region of the one or more peptides on a solid phase from the solid phase by (i) an agent reducing the disulfide bridge, thereby releasing the one or more linear dithiol peptides from the solid phase, wherein the agent is volatile and is removable by evaporation, or (ii) a base that deprotonates the sulfhydryl group in the N-terminal region of the one or more linear dithiol peptides, thereby inducing an intramolecular disulfide exchange thereby releasing the one or more linear dithiol peptides from the solid phase in the form of one or more cyclic peptides.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C40B 50/18 - Synthèse en phase solide, c. à d. dans laquelle au moins un bloc servant à créer la bibliothèque est lié à un support solide au cours de la création de la bibliothèque; Procédés particuliers de clivage à partir du support solide utilisant un procédé particulier d'ancrage au support solide

Abrégé

The present invention is related to a method of volumetric manufacturing a three-dimensional object or article by illuminating a non-transparent and/or absorptive photo-sensitive material with light patterns from multiple angles, comprising the steps of capturing at least one fluorescence or scattering snapshot for one or a set of different illuminating projected patterns in the said photo-sensitive material, obtaining therefrom at least one physical parameter describing the light propagation through the said photo-sensitive material, and computing a set of optimized projected patterns with the aid of the at least one physical parameter, wherein said optimized projected patterns (204) are used for volumetric manufacturing said three-dimensional object or article. The present invention is furthermore related to a device for performing said method.

Classes IPC  ?

• B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
• B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p.ex. par irradiation globale combinée avec un masque
• B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive

Abrégé

The present invention relates to methods and compositions which provide a companion diagnostic for cancer therapy. A method for identifying and stratifying a patient or group of patients with cancer as (i) being high or low for FMRP activity, (ii) having a high or low risk prognosis, and/or (iii) being a responder or non-responder to cancer therapy, and/or (iv) having high or low immune cell infiltrated tumor.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention provides methods for detecting cancer as well as agents and compositions for treating cancer by modulating the expression and/or activity of one or more i) KRAB-containing zinc finger protein (KZFP), ii) mRNA encoding a KZFP, and/or iii) KZFP gene.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

Method for detecting a change in molecular tumbling of an electron-spin labelled system (1) in solution. Nuclear spins of the entire solution are measured in solution using Overhauser dynamic nuclear polarization in a first reference measurement, and then nuclear spins of said electron-spin labelled system (1) and of at least one further molecule (3, 11, 13-16) aggregated and/or linked with at least one of said electron-spin labelled systems (1) and not present in said first measurement, or said electron-spin labelled systems (1) under different conditions or in a different environment than in the first measurement, are measured in solution using Overhauser dynamic nuclear polarization in a second measurement. A difference in Overhauser dynamic nuclear polarization enhancement spectrum between said first and second measurements is taken as a measure of the change in molecular tumbling of said electron-spin labelled system (1) and/or of the presence of an aggregate of said at least one further molecule (3, 11, 13-16) aggregated and/or linked with at least one of said electron-spin labelled systems (1).

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01R 33/62 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance double

Abrégé

The present invention provides methods for detecting cancer as well as agents and compositions for treating cancer by modulating the expression and/or activity of one or more i) KRAB-containing zinc finger protein (KZFP), ii) mRNA encoding a KZFP, and/or iii) KZFP gene.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

The invention regards a method for screening for interactions between two compounds provided in libraries. The invention in particular provides a method for screening interactions, such as a binding between two molecules or macromolecules, that is not limited to a classical screening by bait and prey setup, and therefore allows for a high-complexity screening of large candidate libraries, including screening for immunological interactions such as interactions between T-cells and antigen presenting cells, or B-cells and their antigenic targets.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p.ex. transfert d’énergie de résonance

Abrégé

11'2121'3131'118218110191916 6121461271222'2222'3232'118192 2'11' 2222'21 21' 3232'1 1'11811821050501181911811821050501181960118611101511818 alkyl as solvent, in particular as polar solvent, for chemical reactions, for recrystallizations or extractions.

Classes IPC  ?

• C07D 493/14 - Systèmes condensés en ortho
• C07H 9/04 - Acétals cycliques
• C08G 63/42 - Ethers cycliques; Carbonates cycliques; Sulfites cycliques; Orthoesters cycliques

Abrégé

The invention provides a method for quantifying the number of target entities that were successfully encapsulated into a microfluidic compartment such as a microfluidic droplet. The invention is predicated upon a continuous quantifiable detectable signal corresponding to the quantity of entities encapsulated in a microfluidic compartment. The present invention is useful in the context of high throughput microfluidic screening approaches which require thorough signal normalization in order to reliably improve signal to noise ratio and to reliably identify screening hits.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

The invention relates to a rail pad (10, lOa-v, 10α-η) comprising: a) a pad matrix (1) comprising a first material and b) at least one damping element (2) at least partially encapsulated or embedded in the pad matrix (1), said damping element (2) comprising or consisting of a second material, wherein the second material of the at least one damping element (2) has a damping factor tan delta > 0.5 in the audible frequency of 1000 Hz. Methods for producing the rail pad of the invention are also disclosed.

Classes IPC  ?

• E01B 9/68 - Semelles ou similaires, p.ex. en bois, en caoutchouc, disposées sous le rail, la selle ou le coussinet

Abrégé

The present invention relates to an electrically tunable photonic resonator device for a component having a fast and flat actuation response, comprising: - At least one optical waveguide with an optical interface for coupling in laser light, - At least one optical resonator including a waveguide being made of an optical resonator material, particularly Si3N4, wherein laser light coupled via the at least one optical waveguide is coupled into the at least one optical resonator, - At least one piezo actuator to apply mechanical stress at least partially onto the at least one optical resonator; wherein the at least one optical resonator, the at least one piezo actuator and the at least one optical waveguide are monolithically integrated on a common substrate of the photonic resonator device; - a mechanical mode suppression means configured to attenuate one or more mechanical modes of oscillation caused by an AC operation of the at least one piezo actuator.

Classes IPC  ?

• H01S 5/065 - Accrochage de modes; Suppression de modes; Sélection de modes
• G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
• H01S 5/14 - Lasers à cavité externe
• H01S 5/06 - Dispositions pour commander les paramètres de sortie du laser, p.ex. en agissant sur le milieu actif
• H01S 5/00 - Lasers à semi-conducteurs

Abrégé

The present invention relates generally to the field of long non-coding RNAs and transcription factors and modulation of their expression for use in medicine and agriculture, such as the treatment and prevention of diseases associated with muscle atrophy and the production of livestock. More particularly, the invention provides agonists of Cytor, a long non-coding RNA, e.g. agents that increase the amount of Cytor RNA in skeletal muscle as well as antagonists for Teadl, a transcription factor, e.g. agents that decrease the amount of Teadl RNA or protein in skeletal muscle and their use in therapy.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross- sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/029 - Mesure du débit de sang à la sortie du cœur, p.ex. volume éjecté par minute
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 8/06 - Mesure du débit sanguin
• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores

Abrégé

The present invention proposes a method for detecting anomalous or out-of-distribution images in a machine learning system (1) comprising a pre-training network with a first encoder, and an anomaly detection network with a second encoder. The system is first pre-trained by training the pre-training network, and then subsequently fine-tuned by training the anomaly detection network. According to one example, during pre-training, only unlabelled training images are used, while during fine-tuning, a small fraction of labelled training images is used in addition to unlabelled training images. The method can be applied to both single and multi-domain image data.

Classes IPC  ?

• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06K 9/62 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques

Abrégé

A removable clip connection device particularly adapted to bamboo structures is disclosed, as well as assemblies formed with the same and uses thereof. The clip connection features a base (100) located at a first end (10) of the device, said base having a first surface (101) and a second surface (102); at least a pair of face-to-face branches (201,202), each branch in a pair stemming from the first surface of said base; and a blocking button (301,302) located at the extremity of each branch, defining an opposed second end of the device, wherein each branch in a pair is directed outwardly one with respect to the other so to be elastically pre-tensioned.

Classes IPC  ?

• F16B 2/22 - Clips, c. à d. dispositifs de fixation à serrage effectué uniquement par la résistance à la déformation inhérente au matériau dont est fait le dispositif en matériau élastique, p.ex. un matériau caoutchouteux
• F16B 7/04 - Assemblages par brides ou clips
• F16B 9/00 - Assemblages de tiges ou de pièces tubulaires à des surfaces plates formant angle
• E04B 1/26 - Structures comportant des éléments porteurs allongés, p.ex. colonnes, poutres, ossatures les pièces porteuses étant en bois

Abrégé

The invention provides anti-SARS-CoV-2 antibodies and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection.

Classes IPC  ?

• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN

Abrégé

A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.

Classes IPC  ?

• A61B 5/369 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG]
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio
• A61B 5/374 - Détection de la répartition de fréquence dans les signaux, p.ex. détection des ondes delta, thêta, alpha, bêta ou gamma
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 5/291 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]

Abrégé

One aspect of the present invention relates to a method of fabricating a chemically active fibre device (1) by thermal drawing. The method comprises the steps of providing a preform, the preform comprising a support element (3) at least partially made of a first polymeric material; and carrying out a thermal drawing process of the preform to produce a thermally drawn fibre. The preform comprises one or more chemically active agents and/or biological materials configured to react with a fluid sample when the one or more chemically active agents and/or biological materials are in contact with the fluid sample. In this manner miniaturised lab-in-fibre devices can be fabricated.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• D01D 5/00 - Formation des filaments, fils ou similaires
• D01F 1/00 - Procédés généraux de fabrication de filaments, ou similaires, faits par l’homme
• D01F 8/00 - Filaments, ou similaires, faits par l’homme, conjugués, c. à d. à plusieurs composants; Leur fabrication

Abrégé

The invention relates to activation by inhibitor release (AIR) switches and chemically disruptable heterodimers (CDH), their use in controlling cell signaling components, and their use for treatments and therapies.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The present invention concerns a computer-system-implemented method for predicting properties of a protein molecule, comprising the steps of: receiving an input representation of the protein molecule; applying a surface generator to produce a molecular surface; applying at least one layer of geometric convolution on the molecular surface to produce a set of surface features; and using the set of features to predict the properties of the molecule.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
• G16B 40/20 - Analyse de données supervisée
• G16C 10/00 - Chimie théorique computationnelle, c. à d. TIC spécialement adaptées aux aspects théoriques de la chimie quantique, de la mécanique moléculaire, de la dynamique moléculaire ou similaires
• G16C 20/30 - Prévision des propriétés des composés, des compositions ou des mélanges chimiques
• G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie

Abrégé

A device for optical computing comprises at least one modulator (210, 710, 810, 910, 1010, 1110, 1210, 1310, 1410, 1520, 1610, 1710, 1810, 1910, 2010, 2110, 2210) and at least one waveguide (220, 720, 820, 920, 1020, 1120, 1220, 1320, 1420, 1530, 1620, 1720, 1820, 1920, 2020, 2120, 2220). The at least one modulator (210, 710, 810, 910, 1010, 1110, 1210, 1310, 1410, 1520, 1610, 1710, 1810, 1910, 2010, 2110, 2210) is configured to modulate incident radiation, whereby input radiation is generated. The at least one waveguide (220, 720, 820, 920, 1020, 1120, 1220, 1320, 1420, 1530, 1620, 1720, 1820, 1920, 2020, 2120, 2220) is configured to guide the input radiation along a propagation direction. The at least one waveguide (220, 720, 820, 920, 1020, 1120, 1220, 1320, 1420, 1530, 1620, 1720, 1820, 1920, 2020, 2120, 2220) is configured to nonlinearly optically transform the input radiation propagating in the at least one waveguide, whereby output radiation that is outputted from the waveguide (220, 720, 820, 920, 1020, 1120, 1220, 1320, 1420, 1530, 1620, 1720, 1820, 1920, 2020, 2120, 2220) is optically computed.

Classes IPC  ?

• G06N 3/067 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

A method of manufacturing a fibre comprising a lined channel, using a draw apparatus, the method comprising: providing a preform, comprising a channel extending through the preform, to the draw apparatus; feeding a liner into the channel; heating a portion of the preform; and drawing the heated portion of the preform in order to form a fibre, wherein the liner is held within the channel of the fibre to provide a lined channel within the fibre.

Classes IPC  ?

• B29C 53/14 - Torsion
• B29C 53/60 - Enroulement et assemblage, p.ex. enroulement en spirale hélicoïdal en utilisant des surfaces de formage internes, p.ex. des mandrins
• A61M 25/00 - Cathéters; Sondes creuses
• B29C 55/22 - Façonnage par étirage, p.ex. étirage à travers une matrice; Appareils à cet effet de tubes
• B29C 61/08 - Fabrication de préformes ayant des contraintes internes, p.ex. mémoire plastique par étirage de tubes

Abrégé

The present invention concerns a laser engraving device (1) for engraving a target surface (17). The laser engraving device (1) comprises: a beam splitter (7) for dividing a processing laser beam (25) into a plurality of engraving laser beams (27); a first optical focusing element (11) with an adjustable focal point for focusing the plurality of engraving laser beams (27) onto the target surface (17); and an optical sensor (19) configured to determine the distance between the target surface (17) and the optical sensor (19). The first optical focusing element (11) is connected to the optical sensor (19) by a data link (21) to receive the determined distance from the optical sensor (19). Furthermore, the first optical focusing element (11) is configured to adjust its focal point based on the determined distance received from the optical sensor (19).

Classes IPC  ?

• B23K 26/03 - Observation, p.ex. surveillance de la pièce à travailler
• B23K 26/06 - Mise en forme du faisceau laser, p.ex. à l’aide de masques ou de foyers multiples
• B23K 26/067 - Division du faisceau en faisceaux multiples, p.ex. foyers multiples
• B23K 26/362 - Gravure au laser

Abrégé

ratioratio I of a radius LI of said inlet at the collector end divided by said separation distance L2 is in a range of 0.8 to 1.2.

Classes IPC  ?

• B03C 3/36 - Séparation par effet électrostatique des particules dispersées des gaz ou de la vapeur, p.ex. dans de l'air - Parties constitutives ou accessoires, ou leur fonctionnement commandant le débit de gaz ou de vapeurs
• B03C 3/09 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par la présence d'électrodes planes fixes, les surfaces planes étant perpendiculaires au courant de gaz
• B03C 3/47 - Electrodes collectrices planes, p.ex. en forme d'assiettes, de disques, de grilles
• B03C 3/12 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par la séparation des postes ionisants et collecteurs
• B03C 3/49 - Electrodes collectrices tubulaires

Abrégé

Flexure pivot based system (1) being one of: a force sensor, a force limiting device arranged to exert a predetermined threshold force, a torque limiting device arranged to exert a predetermined threshold torque, a programmable mechanical memory, or an accelerometer, said flexure pivot based system (1) comprising a substantially rigid frame (3) supporting a lever (5) by means of a suspension mechanism (7) comprising: - a first flexure (9) extending from said frame (3) to a junction (15) with said lever (5); - a second flexure (11) extending from said frame (3) to said junction (15) and arranged at a first non-zero angle to said first flexure (9) in a neutral position of said suspension mechanism (7), - a third flexure (13) extending from said junction (15) to a preloading system (17) at a second non-zero angle to at least one of said first flexure (9) and said second flexure (11) in a neutral position of said suspension mechanism, said preloading system (17) being arranged to apply a force in a direction substantially coaxial with said third flexure (13).

Classes IPC  ?

• G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques

Abrégé

22) to be used to fit regularization parameters for unknown spectra via Tikhonov regularization and adaptive dictionary learning.

Classes IPC  ?

• G06T 3/40 - Changement d'échelle d'une image entière ou d'une partie d'image
• G01J 3/00 - Spectrométrie; Spectrophotométrie; Monochromateurs; Mesure de la couleur