Abrégé

A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/374 - Détection de la répartition de fréquence dans les signaux, p.ex. détection des ondes delta, thêta, alpha, bêta ou gamma

Abrégé

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross-sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.

Classes IPC  ?

• A61B 8/06 - Mesure du débit sanguin
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

A micromachined mechanism for a sensing tool includes a support, a probe pivotally mounted with respect to the support, and a beam connected to the support and the probe. The probe is configured to apply a load (Ftool) on a body and to be subjected to a counter-reaction contact force exerted by the body in reaction to the load. The beam is configured to shift from an undeformed position to a deformed position when the contact force of the body is greater than a predetermined threshold force (Fcrit) for which the beam buckles.

Classes IPC  ?

• A61B 5/12 - Audiométrie
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

The present disclosure concerns a membrane-less electrolyzer comprising a first electrode and a second electrode, a first fluidic channel configured to receive an electrolyte, a second fluidic channel configured to receive the electrolyte from the first fluidic channel, a third fluidic channel configured to receive the electrolyte from the first fluidic channel. The first fluidic channel being in fluidic communication with the second and third fluidic channels. The first fluidic channel is connected to the second and third fluidic channels via a plurality of inclined fluidic canals extending from the first fluidic channel to each of the second and third fluidic channels.

Classes IPC  ?

• C25B 11/03 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes

Abrégé

A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque

Abrégé

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

Classes IPC  ?

• A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
• A61F 9/00 - Procédés ou dispositifs pour le traitement des yeux; Dispositifs pour mettre en place des verres de contact; Dispositifs pour corriger le strabisme; Appareils pour guider les aveugles; Dispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
• F04B 43/04 - Pompes ayant un entraînement électrique
• F04B 43/09 - Pompes à entraînement électrique
• F04B 43/12 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles à action péristaltique
• F04B 43/14 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles à action péristaltique ayant des organes flexibles du genre plat

Abrégé

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or within at least a portion of said substrate; ii) a stretchable interconnect comprising an intrinsically elastic substrate, said substrate comprising at least one well or groove comprising at least one compliant conductive element therein, said at least one well or groove being configured to accommodate said at least one conductive track of said interconnection board; and iii) at least one bolus of an electrically conductive paste located within said at least one well or groove, configured to electrically connect said at least one compliant conductive element with said at least one conductive track.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• H05K 1/03 - Emploi de matériaux pour réaliser le substrat
• H05K 1/09 - Emploi de matériaux pour réaliser le parcours métallique
• H05K 3/10 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché
• H05K 3/38 - Amélioration de l'adhérence entre le substrat isolant et le métal

Abrégé

A fin field-effect transistor (FinFET) based semiconductor memory array having a plurality of memory cells, each memory cell including a write transistor having a write wordline gate over a first fin connected to a write wordline gate contact, a write bitline contact in connection with the first fin, and a storage node contact in connection with the first fin, and a read transistor having a storage node gate over a second fin, the storage node gate connected to a storage node gate contact, the storage node gate contact connected to the storage node contact, a read wordline contact in connection with the second fin, and a read bitline contact in connection with the second fin, wherein the write wordline gate and the storage node gate are arranged in series to each other along an extension axis that coincides with an longitudinal axis of the write wordline gate and a longitudinal axis of the storage node gate.

Classes IPC  ?

• G11C 11/419 - Circuits de lecture-écriture [R-W]
• G11C 11/412 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des dispositifs à semi-conducteurs utilisant des transistors formant des cellules avec réaction positive, c. à d. des cellules ne nécessitant pas de rafraîchissement ou de régénération de la charge, p.ex. multivibrateur bistable, déclencheur de Schmitt utilisant uniquement des transistors à effet de champ
• H01L 27/11 - Structures de mémoires statiques à accès aléatoire
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
• H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée

Abrégé

A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., wherein each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from said method are also disclosed.

Classes IPC  ?

• A61L 27/52 - Hydrogels ou hydrocolloïdes
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B33Y 80/00 - Produits obtenus par fabrication additive
• B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p.ex. de buses de jet
• B29C 64/245 - Plates-formes ou substrats
• A61L 27/56 - Matériaux poreux ou cellulaires
• B29C 64/00 - Fabrication additive, c. à d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p.ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
• B29C 35/16 - Refroidissement
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse

Abrégé

ESP particle collector (1) for collecting particles in a particle containing gas stream, comprising an inlet section (4), a collector section (6), and an electrode arrangement (8), the inlet section comprising a flow tube (10) defining a gas flow channel (12) therein bounded by a guide wall (24) extending between an entry end (14) and a collector end (16) that serves as an inlet to the collector section (6), the entry end comprising an inlet (28) for the particle gas stream and a sheath flow inlet portion (26) for generating a sheath flow around the particle gas stream, the collector section comprising a housing (18) coupled to the flow tube, and a collector plate (20) mounted therein having a particle collection surface (23). The ESP particle collector is configured to allow optical analysis of the collector plate particle collection surface to measure particles collected thereon. The electrode arrangement comprises at least a base electrode (8a) positioned below the collection surface and a counter-base electrode (8b) positioned at a separation distance L2 above the collection surface such that an electrical field is generated between the electrodes configured to precipitate said particles on the collection surface, wherein the electric field is in a range of 0.1 kV per mm to 1.5 kV per mm, with an absolute voltage on any said electrode that is less than 10 kV, and wherein a ratio ratio I of a radius L1 of said inlet at the collector end divided by said separation distance L2 is in a range of 0.8 to 1.2.

Classes IPC  ?

• B03C 3/06 - Installations alimentées en électricité de l'extérieur du type par voie sèche caractérisées par la présence d'électrodes tubulaires fixes
• B03C 3/49 - Electrodes collectrices tubulaires
• B03C 3/38 - Postes de chargement ou d'ionisation des particules, p.ex. utilisant des décharges électriques, des radiations radioactives ou des flammes
• B03C 3/36 - Séparation par effet électrostatique des particules dispersées des gaz ou de la vapeur, p.ex. dans de l'air - Parties constitutives ou accessoires, ou leur fonctionnement commandant le débit de gaz ou de vapeurs

Abrégé

Disclosed is a flexure pivot based system being one of: a force sensor, a force limiting device arranged to exert a predetermined threshold force, a torque limiting device arranged to exert a predetermined threshold torque, a programmable mechanical memory, or an accelerometer, the flexure pivot based system including a substantially rigid frame supporting a lever by a suspension mechanism including: a first flexure extending from the frame to a junction with the lever; a second flexure extending from the frame to the junction at a first non-zero angle to the first flexure in a neutral position of the suspension mechanism; and a third flexure extending from the junction to a preloading system at a second non-zero angle to the first flexure and/or the second flexure in the neutral position, the preloading system applying a force in a direction substantially coaxial with the third flexure.

Classes IPC  ?

• G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques

Abrégé

A scintillation device including a silicon plate having a rectangular shape and having a first side and a second side opposite the first side, wherein the first side includes a plurality of first channels arranged to be in parallel with each other extending in a first direction, wherein walls in the silicon plate that form the first channels are coated with an optically reflective or dielectric layer, and wherein the first channels are filled with a scintillation resin in a solid state forming a first waveguide.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/203 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant fait de matières plastiques

Abrégé

A method for manufacturing a scintillation detector structure including the steps of forming a plurality of first structures into a surface of a substrate to form a patterned substrate, filling the plurality of first structures and covering the surface of the substrate with a polymeric material, hardening the polymeric material and first removing the hardened polymeric material from the substrate to obtain a polymeric mold with a patterned surface having a plurality of second structures, performing a surface cleaning treatment and a silanization of the patterned surface of the polymeric mold, filling the plurality of second structures and covering the patterned surface of the polymeric mold with a moldable scintillation material, polymerizing the scintillation material while exerting a pressure on the scintillation material, and second removing the polymerized scintillation material from the plurality of second structures of the polymeric mold to obtain scintillation detector active structures.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
• C08L 83/04 - Polysiloxanes
• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• B29C 33/40 - Matière plastique, p.ex. mousse ou caoutchouc

Abrégé

The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising: obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled; calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum; determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation Δ ⁢ E = f E ⁢ hc λ ⁢ N ⁢ or ⁢ Δ ⁢ E = f E ⁢ E p N .

Classes IPC  ?

• H01J 37/22 - Dispositifs optiques ou photographiques associés au tube
• H01J 37/244 - Détecteurs; Composants ou circuits associés
• H01J 37/28 - Microscopes électroniques ou ioniques; Tubes à diffraction d'électrons ou d'ions avec faisceaux de balayage
• H01J 37/20 - Moyens de support ou de mise en position de l'objet ou du matériau; Moyens de réglage de diaphragmes ou de lentilles associées au support

Abrégé

The invention provides an in vitro method for the cell-free quantification of virus neutralizing activity, such as the SARS-CoV-2 neutralizing activity, of biological samples and kit for carrying out the method. The invention also provides a method of screening biological samples or collections of molecules to identify neutralizing antibodies or antiviral drugs.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, the step of predicting at least one target buried interface site comprises generating at least one surface fingerprint associated with a protein interaction based on at least one protein interface, wherein the at least one surface fingerprint preferably embeds geometric and/or chemical features of molecular surfaces, identifying at least one binding seed that displays required features to engage the target site, and performing a binding seed transplantation to protein scaffolds to confer stability and additional contacts on the designed interface.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
• G16B 20/30 - Détection de sites de liaison ou de motifs
• G16B 40/20 - Analyse de données supervisée

Abrégé

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by between-assembly links, each node assembly itself comprising a network of nodes interconnected by a plurality of within-assembly links, wherein each of the between-assembly links and the within-assembly links have an associated weight, each weight embodying a strength of connection between the nodes joined by the associated link, the nodes within each assembly being more likely to be connected to other nodes within that assembly than to be connected to nodes within others of the node assemblies.

Classes IPC  ?

• G06N 3/045 - Combinaisons de réseaux
• G06N 3/082 - Méthodes d'apprentissage modifiant l’architecture, p.ex. par ajout, suppression ou mise sous silence de nœuds ou de connexions
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

Systems and methods for data storage and readout using hybrid nucleic acid-polymeric molecules are herein disclosed. A molecular data storage medium is presented comprising a header and a footer, each comprising or consisting of at least one unit of a first chemical species; and a sequence-controlled polymeric chain of a second chemical species located between said header and said footer, said polymeric chain encoding for a desired bitstream-format media. A nanopore-based device and methods for decoding digital information from the molecular data storage

Classes IPC  ?

• G11C 13/02 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments dont le fonctionnement dépend d'un changement chimique
• G16B 50/30 - Entreposage de données; Architectures informatiques
• G16B 50/50 - Compression de données génétiques

Abrégé

The present invention relates to a DC/DC converter (1) for transferring an active power between two DC subsystems (5, 6) comprising: —a first converter stage (3) and a second converter stage (4) both configured to be selectively operated as an active inverter or as a passive rectifier; —an AC coupling circuit (2) for coupling the first and the second converter stage (3, 4) by means of an AC power transfer; and —a control unit (10) configured to switch the operation mode of the first and second converter stages (3, 4) depending on a measurement of an amount of power transfer through the AC coupling circuit (2).

Classes IPC  ?

• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation

Abrégé

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Classes IPC  ?

• C25F 3/12 - Attaque de surface des matériaux semi-conducteurs
• B23H 9/14 - Réalisation de trous
• B23H 7/20 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation pour commande de programme, p.ex. commande adaptative
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
• B23H 3/02 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation, commande, prévention des courts-circuits
• C12Q 1/6869 - Méthodes de séquençage
• C25F 7/00 - PROCÉDÉS POUR LE TRAITEMENT D'OBJETS PAR ENLÈVEMENT ÉLECTROLYTIQUE DE MATIÈRE; APPAREILLAGES À CET EFFET Éléments de construction des cellules, ou leur assemblage, pour l'enlèvement électrolytique de matières d'objets; Entretien ou conduite
• G01N 27/447 - Systèmes utilisant l'électrophorèse

Abrégé

The invention relates to methods for the preparation of method of preparation of cDNA library based on one or many RNA samples useful for efficient RNA sequencing and uses thereof. The invention further relates to related tools and kits useful in said method.

Classes IPC  ?

• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p.ex. séquençage par hybridation [SBH]
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

The invention relates to a nanoplasma switch device, comprising: —multiple electrically isolated electrodes; —a gap separating the two electrodes; wherein the gap has a width which is dimensioned to effect the generation of a plasma by electric-field electron emission.

Classes IPC  ?

• H01J 17/06 - Cathodes
• H01T 4/10 - Limiteurs de surtension utilisant des éclateurs ayant un intervalle simple ou plusieurs intervalles disposés en parallèle

Abrégé

The invention relates to oblique transscleral illumination of an eye fundus with at least one physical point light source around the eye allowing for dark field imaging combined with optical coherence tomography imaging

Classes IPC  ?

• A61B 3/12 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p.ex. ophtalmoscopes
• A61B 3/10 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• A61B 3/00 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux
• G06T 7/50 - Récupération de la profondeur ou de la forme

Abrégé

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A blood pressure monitor may be implanted without surgery. The blood pressure monitor may transmit real time blood pressure information to a receiver by wireless data transmission.

Classes IPC  ?

• A61B 5/0215 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par des moyens introduits dans le corps
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

A device and system for e.g. rehabilitation and assistance of hand motor functions, in particular a portable and under-actuated hand exoskeleton for use in activities of daily living, is disclosed.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée
• A61F 5/01 - Dispositifs orthopédiques, p.ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global neural network model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local training dataset (DS1 to DSn) and a vector of output labels (OL1 to OLn) for training the global model. Further, it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the weights of the global model being encrypted with the collective public key. Each data provider (DP1) computes and aggregates, for each layer of the global model, encrypted local gradients (LG1) using the respective local training dataset (DS1) and output labels (OL1), with forward pass and backpropagation using stochastic gradient descent. At least one data provider homomorphically combines at least a subset of the current local gradients of at least a subset of the data providers into combined local gradients, and updates the weights of the current global model (GM) based on the combined local gradients.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• H04L 9/08 - Répartition de clés

Abrégé

An automated music composition and generation system for automatically harmonizing digital pieces of music using an automated music composition and generation engine for multi-voice music harmonization, including a system-user interface configured to input user parameters comprising at least an instrument designation, a composer style designation, an empty or partial input musical score to be automatically completed, whereby the instrument designation and the composer designation are any one of a predetermined list of instrument designations and composer designations, an automated music composition and generation engine configured to implement a generation strategy that produces playable and well-structured multi-voice music scores, operationally connected to the system-user interface, and a neural network module configured to implement a rhythm recurrent artificial neural network model, a melody recurrent artificial neural network model and a harmony feedforward neural network model that have been trained for combinations of the instrument designations and composer designations of the predetermined list.

Classes IPC  ?

• G10H 1/00 - INSTRUMENTS DE MUSIQUE ÉLECTROPHONIQUES; INSTRUMENTS DANS LESQUELS LES SONS SONT PRODUITS PAR DES MOYENS ÉLECTROMÉCANIQUES OU DES GÉNÉRATEURS ÉLECTRONIQUES, OU DANS LESQUELS LES SONS SONT SYNTHÉTISÉS À PARTIR D'UNE MÉMOIRE DE DONNÉES Éléments d'instruments de musique électrophoniques

Abrégé

A device for fragmenting ions by collision induced dissociation, the device intended to be used together with a planar ion mobility apparatus, the device including a first conductive grid having a plurality of first openings, the first conductive grid configured for electric interconnection to a first electric potential, and a second conductive grid having a plurality of second openings, the second conductive grid configured for electric interconnection to a second electric potential, the first and second conductive grids being electrically insulated from each other.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• G01N 27/622 - Spectrométrie de mobilité ionique
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules - Détails

Abrégé

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph includes identifying a directed functional edge of the functional subgraph based on presence of structural connection and directional communication of information across the same structural connection.

Classes IPC  ?

• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage
• G06N 7/01 - Modèles graphiques probabilistes, p.ex. réseaux probabilistes

Abrégé

A method for operating a light microscope comprises emitting and guiding a plurality of illumination light beams towards a specimen (6) to form a plurality of separated illumination light spots (2A, 2B, 2C, 2D) at the specimen; and guiding detection light beams (11) coming from the illumination light spots (2A, 2B, 2C, 2D) to a detector (10) comprising a plurality of sensor arrays (31-34). Each sensor array (31-34) comprises photon-counting detector elements (40), and detection light beams (11) from different illumination light spots (2A, 2B, 2C, 2D) are guided to different sensor arrays (31-34). Measured signals from the sensor arrays (31-34) are analysed to determine positional information about the light spots (15) on the sensor arrays (31 -34). It is adjusted where the light spots (15) hit the sensor arrays (31-34) based on the positional information. A corresponding light microscope is furthermore disclosed.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G01J 1/44 - Circuits électriques
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

Classes IPC  ?

• C08J 3/075 - Gels macromoléculaires
• A61K 9/06 - Onguents; Excipients pour ceux-ci
• A61K 9/50 - Microcapsules

Abrégé

CNG power system (1) comprising a storage tank (6) connected fluidically to a fuel conversion system (2) via an energy transfer system (4), the fuel conversion system (2) comprising a power unit using CNG as fuel and generating gas emissions comprising CO2, the fuel conversion system comprising a CO2 capture unit (16) configured for separating out CO2 from the gas emissions. The energy transfer system comprises a CNG expansion turbine (22) mounted in a fuel circuit (8) between the storage tank and fuel conversion system powered by expansion of the CNG flowing from the storage tank to the fuel conversion system, and a CO2 compressor (24) connected between the fuel conversion system and the storage tank along a CO2 circuit (10) for compressing the CO2, power for driving the CO2 compressor (24) being supplied in part by power generated by the CNG expansion turbine (22).

Classes IPC  ?

• F17C 13/00 - RÉCIPIENTS POUR CONTENIR OU EMMAGASINER DES GAZ COMPRIMÉS, LIQUÉFIÉS OU SOLIDIFIÉS; GAZOMÈTRES À CAPACITÉ FIXE; REMPLISSAGE OU VIDAGE DE RÉCIPIENTS DE GAZ COMPRIMÉS, LIQUÉFIÉS OU SOLIDIFIÉS - Détails des récipients ou bien du remplissage ou du vidage des récipients

Abrégé

A haptic device is disclosed comprising at least one fluidic actuator operatively connectable with pumping means; and a plurality of movable members mechanically connected with said at least one fluidic actuator, wherein said movable members can perform a displacement upon actuation of the fluidic actuator and/or resist the movements of a body part of a user upon actuation of the fluidic actuator, to provide a tactile and/or force haptic sensation to a body part of a user. Methods for providing a haptic sensation to a user and receiving haptic input commands from a user are also disclosed.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• A61H 39/00 - Dispositifs de physiothérapie pour localiser ou stimuler les endroits spécifiques de réflexe du corps, p.ex. acupuncture
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

A method for labelling a portion of a device includes the steps of providing a first substrate layer of a transparent or translucent material, depositing a first coloured material onto the first substrate layer in a labelling portion of the layer, thereby obtaining a labelling item, and coupling the labelling item to the device. The method is particularly suitable for producing labelled stretchable devices such as soft body-implantable devices for sensing a physiological signal and/or stimulating an electrical and/or pharmacological activity of a body tissue or organ in a subject.

Classes IPC  ?

• A61B 90/92 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des codes de couleurs

Abrégé

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• A61P 35/00 - Agents anticancéreux
• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present disclosure relates to a method for generating variants of a protein based on a native protein regulated by allosteric pathway, the method comprising: i) providing 3D structures of the native protein; ii) identifying at least one pair of coupled allosteric sites within the amino acid sequence of the native protein named microswitch; iii) generating in silico mutations of said identified microswitch to generate a pool of variants; iv) computing at least one score reflecting the variation in allosteric coupling; and/or the variation in the relative stability v) predicting the activity of each variant compared to the native protein based on the computed score. The disclosure also concern a computer implemented program to carry out said method, and a variant of a protein or an active fragment thereof, a polynucleotide.

Classes IPC  ?

• C07K 14/72 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des hormones
• G16B 15/20 - Repliement de protéines ou de domaines
• G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
• G16B 20/50 - Mutagénèse

Abrégé

A dielectrophoretic detection device including a chip, with a flow channel having at least one inlet and one outlet, and at least a detection area configured to detect analytes trapped on functionalised beads flowing within the flow channel, first and second electrode assemblies shaped as rows of parallel pillars extending a the height of the flow channel, and configured to generate under electric tension an electric field to form an electrical barrier, and preventing the beads to cross the barrier and drawing the beads to the detection area by dielectrophoretic forces where they are clustered and concentrated. The device may be provided with multiple rows of parallel pillars of electrode assemblies extending over the height of the flow channel, forming multiple concentration lines. The flow channel may be provided with further rows of parallel pillars of electrode assemblies crossing the flow channel in a transverse direction, forming further incubation lines.

Classes IPC  ?

• B03C 5/00 - Séparation de particules des liquides dans lesquels elles sont dispersées, par effet électrostatique
• G01N 1/40 - Concentration des échantillons
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B03C 5/02 - Séparateurs

Abrégé

Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.

Classes IPC  ?

• H04L 25/08 - Modifications pour réduire les perturbations; Modifications pour réduire les effets des défauts de ligne
• H04B 10/54 - Modulation d'intensité
• H04B 7/0413 - Systèmes MIMO
• H04L 25/02 - Systèmes à bande de base - Détails
• H04L 25/49 - Circuits d'émission; Circuits de réception à au moins trois niveaux d'amplitude
• H04L 5/00 - Dispositions destinées à permettre l'usage multiple de la voie de transmission

Abrégé

A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a G protein or an arrestin protein in a cell.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

A computer-implemented inverse rendering method comprising: computing an adjoint image by differentiating an objective function that evaluates the quality of a rendered image, image elements of the adjoint image encoding the sensitivity of spatially corresponding image elements of the rendered image with respect to the objective function; sampling the adjoint image at a respective sample position to determine a respective adjoint radiance value associated with the respective sample position; emitting the respective adjoint radiance value into a scene model characterised by scene parameters; determining an interaction location of a respective incident adjoint radiance value with a surface and/or volume of the scene model; determining a respective incident radiance value or an approximation thereof at the interaction location; and updating a scene parameter gradient.

Classes IPC  ?

• G06T 15/00 - Rendu d'images tridimensionnelles [3D]
• G06T 7/00 - Analyse d'image
• G06T 15/06 - Lancer de rayon
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06T 15/50 - Effets de lumière

Abrégé

A method for producing a carbonate-containing species-rich, nitrogen-containing species-free solution from a urea-rich solution is proposed. The method comprising the steps of: providing a first reservoir comprising a first mixture including urea and a catalyser comprising an enzymatic catalyser and/or a microorganism; allowing an enzymatic reaction catalysed by the catalyser to decompose urea, thereby obtaining a second mixture comprising nitrogen-containing species and carbonate-containing species; converting at least some of the nitrogen-containing species into gaseous nitrogen-containing species to obtain a third mixture comprising the gaseous nitrogen-containing species and the carbonate-containing species; filtering the third mixture by a gas- permeable filter, thereby separating at least some of the gaseous nitrogen-containing species from the carbonate-containing species while keeping the catalyser away from the gas-permeable filter; and collecting the so-obtained carbonate-containing species-rich, nitrogen-containing species-free solution.

Classes IPC  ?

• C09K 17/10 - Ciments, p.ex. ciment Portland
• C04B 12/00 - Ciments non prévus par les groupes  
• C12M 1/04 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques
• E02D 3/12 - Consolidation par mise en place dans le sol de produits solidifiants ou obturant les pores

Abrégé

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.

Classes IPC  ?

• A61L 27/20 - Polysaccharides
• A61F 2/00 - Filtres implantables dans les vaisseaux sanguins; Prothèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corps; Appareils pour les assujettir au corps; Dispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p.ex. stents
• A61F 2/12 - Prothèses mammaires
• A61L 27/16 - Matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/24 - Collagène
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p.ex. substances thérapeutiques
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
• A61L 24/00 - Adhésifs ou ciments chirurgicaux; Adhésifs pour dispositifs de colostomie
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy-preserving distributed training of a global model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local model (LM1 to LMn) and a respective local training dataset (DS1 to DSn) for training the local model using an iterative training algorithm (IA). Further it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the local and global model being encrypted with the collective public key. Each data provider (DP1) trains its local model (LM1) using the respective local training dataset (DS1) by executing gradient descent updates of its local model (LM1), and combining (1340) the updated local model (LM1′) with the current global model (GM) into a current local model (LM1c). At least one data provider homomorphically combines at least a subset of the current local models of at least a subset of the data providers into a combined model (CM1), and updates the current global model (GM) based on the combined model. The updated global model is provided to at least a subset of the other data providers.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité
• G06N 3/098 - Apprentissage distribué, p.ex. apprentissage fédéré

Abrégé

The disclosure relates to dendritic polyglycerols (dPG) compounds with carboxyalkyl, sulfyl or sulfonyl functional groups that irreversibly inhibit viral infection (virucidal effect) through multivalent interaction in nanomolar concentration range. While the compounds of the disclosure show virus inhibition in the nanomolar range they show no in-vitro toxicity in the same range of concentration.

Classes IPC  ?

• A61K 31/765 - Polymères contenant de l'oxygène
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A01N 31/02 - Composés acycliques
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61K 31/795 - Polymères contenant du soufre
• A01N 41/04 - Acides sulfoniques; Leurs dérivés
• C08G 65/48 - Polymères modifiés par post-traitement chimique

Abrégé

A method for enforcing smoothness constraints on surface meshes produced by a Graph Convolutional Neural Network (GCNN) including the steps of reading image data from a memory, the image data including two-dimensional image data representing a three-dimensional object or a three-dimensional image stack of the three-dimensional object, performing a GCNN mesh deformation step on the image data to obtain an approximation of a surface of the three-dimensional object, the surface represented by triangulated surface meshes, at least some vertices of the triangulated surface meshes having a different number of neighboring vertices compared to other vertices in a same triangulated surface mesh, and performing a deep active surface model (DASM) transformation step on the triangulated surface meshes to obtain a corrected representation of the surface of three-dimensional object to improve smoothness of the surface.

Classes IPC  ?

• G06T 17/20 - Description filaire, p.ex. polygonalisation ou tessellation
• G06K 9/62 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques
• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion

Abrégé

The present invention is related to a stretchable tubular device (1) comprising at least one layer (Lx) of a stretchable polymer, a power supply (2) and a set of electrodes (3a, 3b) connected to said power supply (2). The power supply can supply at least a first level of voltage (V1) to the electrodes so as to modify the natural force (F0) of the stretchable layers to a modified force (F1). The present invention also covers a process for manufacturing such a tubular device and its use as a medical implant.

Classes IPC  ?

• A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p.ex. dispositifs permanents d’assistance cardiaque endovasculaire
• A61M 60/486 - Pompes pour le sang; Dispositifs pour l'actionnement mécanique de la circulation; Pompes à ballon d’assistance circulatoire - Détails concernant l’entraînement pour des dispositifs d’actionnement circulatoire mécanique la force agissant sur les moyens d’actionnement étant mécanique, p.ex. éléments à entraînement mécanique de pincement d’un vaisseau sanguin générée par des organes d’actionnement électro-actifs, p.ex. en utilisant des polymères électro-actifs ou des éléments piézoélectriques
• A61M 60/531 - Régulation par des données du patient en temps réel par des données de tension artérielle, p.ex. provenant de capteurs de tension

Abrégé

The invention relates to a photoplethysmography (PPG) sensing device comprising—a pulsed light source, —at least one pixel to create photo-generated electrons, synchronized with said pulsed light source. It is mainly characterized in that each pixel comprises: —a pinned photodiode (PPD) having two electronic connection nodes, —a sense node (SN), to convert the photo-generated electrons into a voltage, and—a Transfer Gate (TGtransfer) transistor, having its source electronically connected to one electronic connection node of said pinned photodiode (PPD), and being configured to act as a transfer gate (TG) between said pinned photodiode (PPD) and said sense node (SN), allowing the photo-generated electrons to sink when the light is pulsed-off, the photo-generated electrons integration when the light is pulsed-on and the transfer of at least part of the integrated photo-generated electrons to said sense node for a read-out.

Classes IPC  ?

• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• H01L 27/14 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des composants semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit ra
• H04N 25/00 - Circuits de capteurs d'images à l'état solide [capteurs SSIS]; Leur commande

Abrégé

The invention discloses a microfluidic device for the culture, selection and/or analysis of sample organisms such as nematodes, as well as for other biological entities such as for instance animal embryos. The device features reservoirs, culture chambers and smart filtering systems allowing fir the selection of specific populations/specimens of sample organisms, thus permitting long-term cultures thereof as well as phenotypic/behavioural analyses. Systems and methods for using the microfluidic device are within the present disclosure as well.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique

Abrégé

A time-resolved multi-gate ion sensitive field effect transducer, including a silicon layer, a P-doped region in the silicon layer and a first electrode in electric connection with the P doped region, a N-doped region in the silicon layer and a second electrode in electric connection with the N-doped region, a general channel area defined in the silicon layer between the P-doped and N-doped regions, a first gate structure forming a sensing area, the first gate structure including a first insulating layer on the silicon layer, the sensing area configured to receive an electrolyte solution, and a third electrode at the sensing area configured to be in contact with the electrolyte solution, the first gate structure configured to generate a first channel area in the silicon layer for providing a first potential barrier, and a second gate structure configured to generate a second channel area in the silicon layer for providing a second potential barrier.

Classes IPC  ?

• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS

Abrégé

Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 39/35 - Allergènes
• A61K 38/28 - Insulines
• A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
• A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 38/38 - Albumines

Abrégé

A composite multi-layer textile, comprising at least one nanofibre layer with nanofibres with diameters below 100 nm and one support layer with microfibres with diameters below three microns, wherein the layers were produced by electrospinning. The multi-layer textile shows a general transmittance at #=550 nm greater than 60%, which shows improved properties concerning transparency, breathability and robustness. This is achieved in that the at least one nanofibre layer and the support layer are fused, forming solid domains in the multi-layer textile, at closed areas of a pattern used in the production process, wherein the solid domains are separated from each other or connected, showing defined shapes, with regular or irregular spatial distribution, while the fibre morphology of nanofibres of the nanofibre layer and microfibres of support layer is preserved on top of the open areas beside the solid domains, attaining a general transmittance greater than that given by the sum of the individual layers.

Classes IPC  ?

• B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p.ex. fibres synthétiques
• B01D 39/08 - Tissus filtrants, c. à d. matériau tissé, tricoté ou entrelacé
• B32B 3/26 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche comportant des cavités ou des vides internes
• B32B 5/02 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments
• B32B 7/05 - Liaison entre couches les couches n’étant pas liées sur toute la surface, p. ex. liaison discontinue ou par motifs particuliers
• B32B 27/12 - Produits stratifiés composés essentiellement de résine synthétique adjacente à une couche fibreuse ou filamenteuse
• B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
• D01D 5/00 - Formation des filaments, fils ou similaires
• D04H 1/728 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes caractérisés par la méthode de formation des voiles ou couches, p.ex. par la réorientation des fibres les fibres étant disposées au hasard par électrofilage
• D04H 1/4382 - Fibres obtenues par étirage de film réticulé; Fibres composites; Fibres mixtes; Fibres ultrafines; Fibres pour cuir artificiel
• D04H 1/558 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p.ex. par fusion partielle ou dissolution en combinaison avec des traitements mécaniques ou physiques autres que le gaufrage
• D04H 1/4334 - Polyamides
• A62B 23/02 - Filtres en vue de la protection des voies respiratoires pour appareils respiratoires

Abrégé

A passive device comprising a hollow waveguide including first and second wall structures extending in a guiding direction, an interconnecting base extending between the wall structures and an enclosure extending between the wall structures, the enclosure being located opposite the interconnecting base; and at least one array of coupled resonant structures enclosed inside the waveguide, the array being configured to provide coupled local resonators and a microwave or millimeter wave frequency passband for providing at least one selected microwave or millimeter wave signal, the array extending along the guiding direction and being located between the wall structures. Each resonant structure extends from the interconnecting base into the hollow waveguide to define a microwave or millimeter wave subwavelength resonant structure, and successive resonant structures are separated by a microwave or millimeter wave subwavelength distance. A resonance frequency of the resonant structures is less than a cut-off frequency of the waveguide.

Classes IPC  ?

• H01P 1/208 - Cavités en cascade; Résonateurs en cascade situés à l'intérieur d'une structure en forme de guide d'ondes creux
• H01P 3/12 - Guides d'ondes creux

Abrégé

Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Classes IPC  ?

• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• C07K 14/77 - Ovalbumine
• A61K 38/20 - Interleukines
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 38/38 - Albumines
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61K 39/35 - Allergènes
• A61K 38/37 - Facteurs VIII
• C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
• A61K 38/16 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• A61K 38/28 - Insulines
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

Classes IPC  ?

• A61K 38/38 - Albumines
• A61K 39/35 - Allergènes
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• A61K 38/28 - Insulines

Abrégé

The invention relates to virucidal compositions comprising a sialic acid (SA) moiety, pharmaceutical compositions and disinfection and/or sterilization compositions comprising thereof and uses thereof in disinfection and/or sterilization methods and in treating and/or preventing COVID-19 and other respiratory diseases caused by coronaviruses and/or influenza viruses.

Classes IPC  ?

• A61K 31/724 - Cyclodextrines
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

The present invention concerns a perovskite solar cell provided with a polymer-porous template composite material for absorbing toxic metal ions. Preferably, the porous template material is a metal oxide framework (MOF) material. An example of a preferred polymer-porous template composite material is PDA-Fe-BTC (polydopamine-Fe1,3,5-benzenetricarboxylate). In experiments mimicking breakage of the solar cell modules, the presence of the polymer-MOF material was shown to result in the capture of lead and thus to reduced leakage of lead.

Classes IPC  ?

• H01L 51/44 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement en énergie électrique, soit comme dispositifs de commande de l'énergie électrique par ledit rayonnement - Détails des dispositifs
• B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance organique
• H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
• H01L 31/048 - Encapsulation de modules

Abrégé

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/35 - Allergènes
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• A61K 38/38 - Albumines
• A61K 38/28 - Insulines

Abrégé

The present invention relates to a method for fabricating an integrated electronic device with a microchannel, comprising the steps of: —Providing a homogeneous or heterogeneous substrate with one or more layers of material, respectively; —Forming at least one trench in the upper surface and through the upper layer using an etching process, particularly using a high aspect ratio etching process; —Sealing the trench by closing the opening of the trench on an upper surface of the upper layer.

Classes IPC  ?

• H01L 23/473 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température impliquant le transfert de chaleur par des fluides en circulation par une circulation de liquides

Abrégé

The invention relates to methods and systems for determining the intention of a subject to perform a voluntary action based on the analysis of the subject's respiratory phases and neuroelectrical signals.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnie; Test des temps de réaction
• A61B 5/0205 - Evaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p.ex. de l'état cardiaque et respiratoire
• A61B 5/369 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG]

Abrégé

The invention discloses systems and methods for generation of microfluidic jets providing a tool for very precise and localized delivery of e.g., medicaments. The proposed solution overcomes shortcomings related to miniaturization of a jet injection technology by implementing laser energy as a driving mechanism and optical fibers for its delivery. Solving the step of miniaturization can allow building new tools compatible with minimally invasive surgical techniques, high parallelization of jet injection units or design of new ergonomic injection devices.

Classes IPC  ?

• A61M 5/30 - Seringues pour injection par projection, sans aiguille, p.ex. utilisables avec des ampoules ou des cartouches échangeables
• A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p.ex. d'une fibre optique; Pièces à main à cet effet
• A61M 5/20 - Seringues automatiques, p.ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An active noise reduction system (2) comprising an electroacoustic plasma transducer (5) for mounting in an installation structure and an acoustic sensing system (11). The electroacoustic plasma transducer comprises a plasma electrode arrangement (6) including a collector electrode (8) and a corona electrode (9), and a control system (7) connected to the plasma electrode arrangement for supplying power to the plasma electrode arrangement. The control system comprises a controller (12), and a amplification circuit (13). The acoustic sensing system is connected to the control system providing a measurement signal of an environmental sound to control the output of the electroacoustic transducer for reducing noise. The control system comprises a filter implementing a control transfer function θ(ω) based on a model of the electroacoustic plasma transducer.

Classes IPC  ?

• G10K 11/178 - Procédés ou dispositifs de protection contre le bruit ou les autres ondes acoustiques ou pour amortir ceux-ci, en général utilisant des effets d'interférence; Masquage du son par régénération électro-acoustique en opposition de phase des ondes acoustiques originales

Abrégé

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for generating model neurons. In one aspect, a method includes receiving a plurality of descriptions of branches of dendrites of one or more neurons and generating a collection of model neurites. Each of the descriptions characterizes, for an individual branch, i) a distance from a cell body at which the individual branch first bifurcates and ii) a distance from the cell body at which the individual branch actually terminates. Generating the collection of model neurites includes repeatedly selecting a description of a branch from the plurality and probabilistically generating a topology of a model neurite based on the selected description. The probabilistic generation of the model neurite includes deciding whether to bifurcate, terminate, or continue the model neurites at different positions based on the selected description.

Classes IPC  ?

• G06N 3/06 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone

Abrégé

In a LIDAR device (100) a laser light source (110) generates first laser light having a first laser frequency which is frequency modulated with a first frequency modulation. A non-linear optical element (120) receives the first laser light and generates therefrom second laser light having a comb-like frequency spectrum with a plurality of second laser frequencies which are each frequency modulated with a second frequency modulation defined by the first frequency modulation. A frequency excursion of the second frequency modulation is smaller than a spacing of the second laser frequencies. A diffractive element (140) spatially separates the second laser light according to the second laser frequencies and directs the spatially separated second laser light towards a ranging region (200), with each of the second laser frequencies being directed towards a corresponding spatially distinct target position in the ranging region (200). A detector (150) receives reflections of the second laser light from the ranging region (200) and measures, by simultaneously detecting a frequency modulation of the reflections for each of the second laser frequencies, a distance and/or a velocity at the target position corresponding to the second laser frequency.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire
• G01S 17/58 - Systèmes de détermination de la vitesse ou de la trajectoire; Systèmes de détermination du sens d'un mouvement

Abrégé

The present disclosure provides devices, systems, and methods for spinal cord stimulation. In some exemplary embodiments, a lead is provided. In one exemplary embodiment, the lead includes a paddle and an electrode array distributed in the paddle. The electrode array includes a first column of electrodes and a second column of electrodes. The first column of electrodes and the second column of electrodes are symmetric about the midline of the paddle. The first column of electrodes includes a first electrode, a second electrode, and a third electrode. The second column of electrodes includes a fourth electrode corresponding to the first electrode, a fifth electrode corresponding to the second electrode, and a sixth electrode corresponding to the third electrode. A vertical inter-electrode distance between the first electrode and the second electrode is larger than that between the second electrode and the third electrode.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• H01B 5/14 - Conducteurs ou corps conducteurs non isolés caractérisés par la forme comprenant des couches ou pellicules conductrices sur supports isolants

Abrégé

The present invention describes an imaging system that allows visualization of a wide range of samples both in terms of morphology and in terms of material (e.g. density distribution, varying chemical composition, or anything that induces a change of optical path). The application of this imaging system includes absorptive samples as well as nearly and fully transparent samples with respect to the wavelength of illumination. The present invention describes an imaging system that allows visualization of a wide range of samples both in terms of morphology and in terms of material (e.g. density distribution, varying chemical composition, or anything that induces a change of optical path). The application of this imaging system includes absorptive samples as well as nearly and fully transparent samples with respect to the wavelength of illumination. Two elements are key in this system: the use of a so-called lock-in camera, and the synchronization of the recording to a modulation of choice along the image forming apparatus. Such modulation can consist for example in modulation of the illumination, use of filters, tilt/rotation of the sample or of certain microscope components.

Classes IPC  ?

• G02B 21/14 - Condensateurs donnant un éclairage pour une observation en contraste de phase
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/08 - Condensateurs

Abrégé

Presented herein are systems and methods for measuring sweat rate of a subject using a wearable system. A sweat rate may be determined automatically based on one or more signals produced by a wetting sensor module in response to a presence of sweat in the wearable system. The one or more signals may be produced using a sweat presence monitoring device, for example comprising two or more electrodes that are operable to make conductance measurements. In some embodiments, sweat drops are periodically collected by the wearable system and individually detected by the wetting sensor module such that the sweat rate is determined based on the periodic detection of the drops. In some embodiments, an energy barrier is used to produce periodic flow of sweat through the wearable device detected by the wetting sensor module such that the sweat rate is determined based on the periodic flow.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang

Abrégé

A laser treatment system and method for imparting beneficial residual stresses into a desired part during production thereof by a Selective Laser Sintering or Melting (SLS/SLM) process, the method including repeatedly subjecting the part to an in-situ Laser Shock Peening (LSP) treatment during the SLS/SLM process. The in-situ LSP treatment includes selectively bringing an LSP module in contact with a surface of the part during the SLS/SLM process, and subjecting the LSP module to the action of a first laser beam to impart beneficial residual stresses into the part. The LSP module is movable between a building chamber where the part is being produced for the purpose of carrying out the in-situ LSP treatment, and a separate storage chamber when the LSP module is not used for the purpose of carrying out the in-situ LSP treatment. The invention is also implementable in a corresponding additive manufacturing system and method.

Classes IPC  ?

• B22F 10/50 - Traitement des pièces ou des articles pendant leur formation, p.ex. traitements appliqués aux couches fusionnées pendant leur formation
• B23K 26/356 - Travail par rayon laser, p.ex. soudage, découpage ou perçage  pour le traitement de surface par traitement par choc
• B23K 26/342 - Soudage de rechargement
• B23K 26/16 - Enlèvement de résidus, p.ex. des particules ou des vapeurs produites pendant le traitement de la pièce à travailler
• B23K 26/70 - Opérations ou équipement auxiliaires
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
• B33Y 40/20 - Posttraitement, p.ex. durcissement, revêtement ou polissage
• B22F 12/41 - Moyens de rayonnement caractérisés par le type, p.ex. laser ou faisceau d’électrons
• B22F 12/70 - Moyens d’écoulement des gaz
• C21D 10/00 - Modification des propriétés physiques autrement que par traitement thermique ou déformation

Abrégé

A data processing apparatus locates source cells responsible for an electrical anomaly in a subject's body part. The apparatus comprises means for: obtaining one or more electrical signals resulting from electrical activity of one or more source cells in the subject's body part; time-reversing the one or more electrical signals for obtaining one or more time-reversed electrical signals; feeding the one or more time-reversed electrical signals into a simulation model of the subject's body part, which is configured to model anatomy and/or electrical activity of the subject's body part, to cause the time-reversed electrical signals when fed into the simulation model to converge in the simulation model at one or more convergence locations; and identifying the one or more convergence locations in the simulation model thereby allowing locating the source cells responsible for the electrical anomaly.

Classes IPC  ?

• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local

Abrégé

The present relates to a device being used in modular building construction comprising at least one flat load support comprising a first main face and a second main face, at least one elongated load support designed for being coupled with said flat load support. The device is characterized in that said flat load support comprises an array of transverse openings extending through the thickness of the flat load support. The flat load support is arranged for fastening said flat load support with said elongated load support at any position corresponding to one of said opening in a reversible manner and to any position between said openings in a reversible manner. Each flat load support comprises reversible lateral connection means and/or reversible transversal connection means for coupling flat load supports in a reversible manner. The flat load support and the elongated load support are arranged for being detachably assembled to provide the modular, reversible, and/or versatile building construction. The invention further relates to a modular construction building based on said device and to a method using said device.

Classes IPC  ?

• E04B 5/43 - Structures de planchers de conception particulière; Caractéristiques relatives à la stabilité élastique; Structures de planchers spécialement conçus pour reposer uniquement sur des colonnes, p.ex. planchers-champignons
• E04B 1/343 - Structures caractérisées par des parties mobiles, séparables ou repliables, p.ex. pour le transport
• E04B 5/02 - Structures portantes de planchers, formées essentiellement d'éléments préfabriqués

Abrégé

A dielectric elastomer actuator comprising: a plurality of polymer layer; a plurality of stretchable electrode layers, each polymer layer being sandwiched between two electrode layers so as to control the electric field within the polymer layer; at least one stretchable charge distribution layer, each charge distribution layer being adjacent to one stretchable electrode layer and/or to one polymer layer.

Classes IPC  ?

• H01L 41/193 - Compositions macromoléculaires
• H01L 41/09 - Eléments piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique
• H01L 41/047 - Electrodes
• H01L 41/083 - Eléments piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche

Abrégé

The present invention relates to a photodetector array for capturing image data, comprising: photodetector cells arranged on a substrate, each including a single-photon avalanche diode, wherein the active areas of the photodetector cells are neighbored along a hexagonal grid; microlenses, having a hexagonal or circular shape, each arranged on one photodetector cell to focus light onto the photodiode.

Classes IPC  ?

• H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche
• H01L 27/146 - Structures de capteurs d'images
• G02B 21/00 - Microscopes
• G02B 19/00 - Condenseurs

Abrégé

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Classes IPC  ?

• C25F 3/12 - Attaque de surface des matériaux semi-conducteurs
• B23H 9/14 - Réalisation de trous
• B23H 3/02 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation, commande, prévention des courts-circuits
• B23H 7/20 - Circuits électriques spécialement adaptés à cet effet, p.ex. alimentation pour commande de programme, p.ex. commande adaptative
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c. à d. ISFETS ou CHEMFETS
• C12Q 1/6869 - Méthodes de séquençage
• C25F 7/00 - PROCÉDÉS POUR LE TRAITEMENT D'OBJETS PAR ENLÈVEMENT ÉLECTROLYTIQUE DE MATIÈRE; APPAREILLAGES À CET EFFET Éléments de construction des cellules, ou leur assemblage, pour l'enlèvement électrolytique de matières d'objets; Entretien ou conduite
• G01N 27/447 - Systèmes utilisant l'électrophorèse
• G01R 19/00 - Dispositions pour procéder aux mesures de courant ou de tension ou pour en indiquer l'existence ou le signe

Abrégé

The present disclosure relates to new agents useful for anti-cancer therapy such as anti-cancer adoptive T-cell transfer (ACT) immunotherapy or immune check-point blockade therapy and related compositions, uses and methods thereof.

Classes IPC  ?

• A61K 38/20 - Interleukines
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to an antimicrobial surface comprising a first array of nano/micro structures spaced apart on a support, characterized in that it comprises a second array of spaced apart nanostructures located on said support and on said first array nanostructures, said second array nanostructures having different size features compared to the nanostructures of said first array.

Classes IPC  ?

• A01N 25/34 - Formes façonnées, p.ex. feuilles, non prévues dans l'un quelconque des autres sous-groupes du présent groupe principal
• A61L 29/08 - Matériaux de revêtement

Abrégé

The invention discloses a system and method to obtain a set of corrected projected patterns from an integrated 3D measurement system so that the solidification of the formed object appears at the same time in a volumetric printer such as a tomographic back-projection or multi-beam printer, hence ensuring that the object is formed with the highest fidelity and spatial resolution.

Classes IPC  ?

• B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
• B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p.ex. par irradiation globale combinée avec un masque
• B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p.ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
• G06T 7/00 - Analyse d'image

Abrégé

Glucose sensors comprising a mutated biomolecule immobilised to a substrate are disclosed. The biomolecule is glucose oxidase, concanavalin A, or glucose binding protein. The mutated biomolecule is immobilised to the substrate via a linker comprising a thiol reactive group and a substrate adherence group. The biomolecule is mutated to introduce one or more surface accessible thiol moieties. The mutated biomolecule is connected to the linker via the one or more surface accessible thiol moieties on the biomolecule and the thiol reactive group on the linker.

Classes IPC  ?

• C12Q 1/54 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir le glucose ou le galactose
• C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une oxydoréductase

Abrégé

The present invention is related to a method of digitally compensating distortions of rays of a light beam in tomography-based additive manufacturing, wherein said tomography-based additive manufacturing involves projecting light patterns from multiple angles into a container (22) comprising photoresponsive material, by simulating the path of the light rays through the container (22) and the photoresponsive material; and digitally compensating the light projections based on the simulated path of the light rays, so as to obtain modified light projections. The present invention is also related to a method and apparatus for preparing an object (24) in tomography-based additive manufacturing, employing said distortion compensation method.

Classes IPC  ?

• B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additive; Leurs parties constitutives ou accessoires à cet effet
• B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive
• B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p.ex. par irradiation globale combinée avec un masque
• B29C 64/241 - Moyens d’entraînement pour mouvement rotatif

Abrégé

Data transformer apparatus comprising a dispatcher module, a reader module, a converter module and a writer module; the dispatcher module is configured to receive a data transformation request including a first and a second information items; the reader module is configured to retrieve data to be transformed, according to said first information item; obtain the type attribute of the data to be transformed, based on said first information item; send the data to be transformed and the type attribute to the converter module; the converter module is configured to select transformation instructions based on said type attribute; execute, on the data to be transformed, the selected transformation instructions, thereby obtaining transformed data; send the transformed data to the writer module; the writer module is configured to; write the transformed data in an output buffer according to said second information item.

Classes IPC  ?

• G06F 12/00 - Accès à, adressage ou affectation dans des systèmes ou des architectures de mémoires
• G06F 12/02 - Adressage ou affectation; Réadressage
• G06F 9/30 - Dispositions pour exécuter des instructions machines, p.ex. décodage d'instructions
• G06F 12/1027 - Traduction d'adresses utilisant des moyens de traduction d’adresse associatifs ou pseudo-associatifs, p.ex. un répertoire de pages actives [TLB]

Abrégé

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

Classes IPC  ?

• A61L 27/56 - Matériaux poreux ou cellulaires
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 27/38 - Cellules animales
• A61L 27/22 - Polypeptides ou leurs dérivés

Abrégé

Sensors comprising B-L-S; wherein: B is a biomolecule comprising one or more surface-exposed thiol moieties, L is a thiol reactive linking group, and S is a substrate; wherein L is covalently linked to B via the one or more surface-exposed thiol moieties.

Classes IPC  ?

• C12Q 1/54 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir le glucose ou le galactose
• C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une oxydoréductase

Abrégé

The present invention concerns an elongated capacitive sensor for fluid monitoring. The sensor comprising: a fibre support made of a dielectric material or dielectric composite material; and a first electrode and a second electrode arranged longitudinally along the fibre support, the first and second electrodes forming together with the fibre support a capacitive sensing element whose capacitance is dependent upon one or more electrical properties of one or more materials inside the support and/or outside the support, and/or is dependent upon a change of materials configuration and associated overall change of one or more electrical properties inside the support and/or outside the support.

Classes IPC  ?

• G01F 1/56 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets électriques ou magnétiques
• G01L 1/14 - Mesure des forces ou des contraintes, en général en mesurant les variations de la capacité ou de l'inductance des éléments électriques, p.ex. en mesurant les variations de fréquence des oscillateurs électriques
• G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
• G01K 7/34 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments capacitifs
• B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes

Abrégé

The invention relates to a vaginal fluid monitoring device embedded into a feminine sanitary pad, said device comprising a stack of the following elements: An absorbent layer (100) configured to be in proximity to, and collect, a vaginal fluid; and A biosensing system (1000) in fluidic connection with said absorbent layer (100), said biosensing system (1000) comprising: A microfluidic chip (200) configured to perform an immunoassay to detect the presence and/or the concentration of at least one target biomarker comprised in a vaginal fluid; Means (300) for providing a readout of the presence and/or the concentration of said at least one target biomarker; and An electrode array (400) located along the microfluidic chip (200) configured to detect and analyze the flow of said vaginal fluid by impedance means; wherein said immunoassay is configured to detect the presence and/or the concentration of at least one target biomarker indicative of a pre-term birth (PTB) risk and/or premature rupture of membrane (PROM) risk. The invention also relates to a method for detecting at least one target biomarker comprised in a vaginal fluid.

Classes IPC  ?

• A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61F 13/472 - Serviettes hygiéniques, garnitures ou couches pour incontinence spécialement adaptées pour un usage féminin
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Hotspot monitoring system for superconducting devices including: —a superconductor; —a first optical waveguide attached to the superconductor for providing a first optical signal; —a second optical waveguide for providing a reference signal; and—interference means configured to overlay or superimpose the first optical signal and the reference optical signal to produce an optical interference signal.

Classes IPC  ?

• G01J 5/48 - Thermographie; Techniques utilisant des moyens entièrement visuels
• G01J 5/58 - Pyrométrie des radiations, p.ex. thermométrie infrarouge ou optique en utilisant un effet d’extinction

Abrégé

The invention describes a composition containing a) a functionalized polymer 10 that comprises at least one polyester segment 13 and at least one, in particular at least two, polymer aggregating segment 11, 12 capable of forming non-covalent bonds based on a supramolecular interaction, b) an aggregating additive 20 that comprises at least one additive aggregating segment 21 capable of forming non-covalent bonds based on the same supramolecular interaction as the polymer aggregating segments 11, 12, wherein the polymer aggregating segments 11, 12 and the additive aggregating segment 21 are ditopic, wherein the polymer aggregating segments 11, 12 and the additive aggregating segment 21 are designed such that they can form aggregates 31 that contain polymer aggregating segments 11, 12 and additive aggregating segments 21, and wherein the polyester segment (13) has a number average molecular weight of from 10′000 g/mol to 500′000 g/mol. The invention also describes a functionalized polymer 10 that comprises at least one polyester segment 13 and at least two polymer aggregating segments 11, 12 capable of forming non-covalent bonds based on a supramolecular interaction, wherein the polymer aggregating segments 11, 12 are ditopic and designed such that they can form aggregates and wherein the polyester segment 13 has a number average molecular weight of from 10′000 g/mol to 500′000 g/mol. The invention also describes a method for the preparation of sheets, films, fibers, or molded parts from the composition or the functionalized polymer 10 according to the invention, sheets, films, fibers, or molded parts comprising a composition or a functionalized polymer 10 according to the invention, and the use of the composition according to the invention for the preparation of sheets, films, fibers, or molded parts.

Classes IPC  ?

• C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p.ex. lactones
• C08J 5/18 - Fabrication de bandes ou de feuilles

Abrégé

Systems and methods are provided for that use noninvasively measured physiologic parameters to predict in real time noninvasively unobservable cardiovascular parameters by employing a one-dimensional arterial tree numerical model calibrated with representative patient data. The numerical model further may be trained and calibrated on a larger database that includes synthetic data using machine-learning algorithms to provide a robust generalized estimator for multiple cardiovascular and hemodynamic parameters.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p.ex. contre la peau; Ophtalmodynamomètres
• A61B 7/02 - Stéthoscopes
• A61B 5/318 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG]
• A61B 5/02 - Mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin; Détermination combinée du pouls, du rythme cardiaque, de la pression sanguine; Evaluation d'un état cardio-vasculaire non prévue ailleurs, p.ex. utilisant la combinaison de techniques prévues dans le présent groupe et des techniques d'électrocardiographie; Sondes cardiaques pour mesurer la pression sanguine

Abrégé

The present invention relates to an inhibitor of sphingolipids for use in the treatment or prevention of an aging related-disease and/or aging.

Classes IPC  ?

• A61K 31/201 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p.ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p.ex. acides oléique ou linoléique
• A61K 31/7105 - Acides ribonucléiques naturels, c. à d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester 
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• C12N 9/04 - Oxydoréductases (1.), p.ex. luciférase agissant sur des groupes CHOH comme donneurs, p.ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 9/02 - Oxydoréductases (1.), p.ex. luciférase
• C12N 9/10 - Transférases (2.)
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p.ex. kinases (2.7)
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)

Abrégé

A method and system for deriving particle characteristics is described. The method comprises imaging the movement of at least one free-floating particle in a liquid environment at at least one moment in time, determining for at least one moment in time a movement parameter based on the imaged movement of the free-floating particles in the liquid environment, and deriving from the movement parameter a characteristic of the at least one particle.

Classes IPC  ?

• G01N 15/14 - Recherche par des moyens électro-optiques
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

b) is at least three times lower than a mechanical stiffness of the actuator body (32). Moreover, a valve actuator unit comprises such an actuator (22) and a housing, wherein the actuator (22) is arranged within the housing and the remainder of the housing is filled with a gas. Additionally, a valve comprises such a valve actuator unit and a valve element, wherein the valve element is movable by the valve actuator unit.

Classes IPC  ?

• F16K 31/00 - Moyens de fonctionnement; Dispositifs de retour à la position de repos
• F16K 7/14 - Dispositifs d'obturation à diaphragme, p.ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture à diaphragme plat, en forme d'assiette ou en forme de bol disposé pour être déformé contre un siège plat
• H02N 1/00 - Générateurs ou moteurs électrostatiques utilisant un porteur mobile de charge électrostatique qui est solide

Abrégé

The present invention is related to a method and apparatus for the volumetric fabrication of three-dimensional objects or articles from photoresponsive materials loaded with scattering particles, by adjusting the refractive index of said photoresponsive material (12) so as to match the refractive index of said scattering particles (30), and/or using a light source emitting light of a wavelength longer than 630 nm, preferably in a range from 630 nm to 1050 nm, more preferably in a range from 650 nm to 900 nm.

Classes IPC  ?

• B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p.ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
• B29C 64/291 - Agencements pour irradiation pour un fonctionnement dans un ensemble, p.ex. avec des activateurs ou des inhibiteurs sélectivement appliqués
• B29C 64/314 - Préparation
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 40/10 - Prétraitement
• B33Y 70/10 - Composites de différents types de matériaux, p.ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux

Abrégé

Polishing method comprising the steps of: —providing at least one crystalline layer or substrate, the at least one crystalline layer or substrate extending in at least one plane, and including at least one outer surface and at least one depression extending from the at least one outer surface; and —polishing the at least one outer surface using ion beam etching (IBE) or an accelerated inert gas ion beam, the ion beam being incident on the at least one outer surface at non-normal incidence or at a non-zero angle (θ) with respect to the surface normal of the at least one plane of the crystalline layer or substrate.

Classes IPC  ?

• C30B 33/12 - Gravure dans une atmosphère gazeuse ou un plasma
• H01J 37/305 - Tubes à faisceau électronique ou ionique destinés aux traitements localisés d'objets pour couler, fondre, évaporer ou décaper
• C30B 29/04 - Diamant

Abrégé

The present invention relates to a cyclic inhibitor of a kallikrein protease comprising or consisting of (I) the peptide (X1 (X2)(X3)R(X4)(X5)(X6)(X7)(X8)(X9)(X10)(X11) (Formula (X)), wherein (X1) is present or absent and, is preferably present, and if present, is an amino acid, and is most preferably D-alanine or G; (X2) is an amino acid with a side chain; (X3) is an amino acid with a polar uncharged side chain, is preferably with a polar uncharged side chain comprising a hydroxyl group, is more preferably T or S and is most preferably T; (X4) is an amino acid, preferably citrulline, Q or E; (X5) is an amino acid, preferably an amino acid with a hydrophobic side chain; (X6) is present or absent, is preferably absent, and, if present, is an amino acid with a negatively charged side chain, preferably D; (X7) is present or absent, is preferably present, and, if present, is an amino acid, more preferably an amino acid with a side chain comprising a pyrrole of indole, even more preferably P, hydroxyl-proline, (R)-3-piperidine carboxylic acid or W, and most preferably P; (X8) is present or absent and, if present, is an amino acid, and is preferably absent; (X9) is present or absent and, if present, is an amino acid, and is preferably absent; (X10) is an amino acid with a side chain; and (X11) is present or absent and, if present, is an amino acid, and is preferably absent; wherein the side chains of (X2) and (X10) are connected via a connecting molecule, said connecting molecule having at least two functional groups, each functional group forming a covalent bond with one of the side chains of (X2) and (X10); and wherein the kallikrein protease is Kallikrein-related peptidase (KLK5); or (II) the peptide (Y1)(Y2)(Y3) (Y4)(Y5)(Y6)(Y7)(Y8)(Y9) (Formula (Y)), wherein (Y1) is present or absent, is preferably present, and, if present, is an amino acid, preferably P, L-beta-hydroxyl-proline, D-proline, (R)-3-piperidine carboxylic acid, Q or R, and is most preferably P; (Y2) is an amino acid with a side chain; (Y3) is I, L or L-Neopentylglycine, and is preferably L; (Y4) is Y or F, and is preferably Y; (Y5) is an amino acid, preferably an amino acid with a hydrophobic side chain, or Q or R, is more preferably L, norleucine, Q, I, R or M, and is most preferably norleucine or L; (Y6) is an amino acid, preferably an amino acid with a hydrophobic side chain and is most preferably A; (Y7) is absent or present, preferably present and, if present, is an amino acid preferably Q, homoarginine, 4-guanidino-phenlalanine or R; (Y8) is an amino acid with a side chain; and (Y9) is present or absent and, if present, is an amino acid, preferably S, and is most preferably absent; wherein the side chains of (Y2) and (Y8) are connected via a connecting molecule, said connecting molecule having at least two functional groups, each functional group forming a covalent bond with one of the side chains of (Y2) and (Y8); and wherein the kallikrein protease is Kallikrein-related peptidase 7 (KLK7).

Classes IPC  ?

• C07K 7/64 - Peptides cycliques ne comportant que des liaisons peptidiques normales
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques

Abrégé

A flow directed device adapted to be guided by a fuid, such as blood, flow within a tubular structure such as a blood vessel is disclosed, said device comprising a proximal end (100), a distal end (101) and an elongated body (102) in between defining a longitudinal axis (103), characterized in that said distal end (101) comprises a ferromagnetic area or structure (300) capable of deflecting the distal end (101) when subjected to an external magnetic field. A system comprising the device, as well as method of use of the device, are also disclosed.

Classes IPC  ?

• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters

Abrégé

The invention relates to an image sensor comprising a photodetector array including neighboring photodetector elements, each photodetector element comprising:—a photodetector cell having a photodiode and a reset unit;—a cell control unit coupled with the photodetector cell and configured to reset the photodiode by means of the reset unit; wherein the cell control unit is configured to asynchronously effect resetting of the photodiode after a given dead time after detection of a photon.

Classes IPC  ?

• H04N 5/3745 - Capteurs adressés, p.ex. capteurs MOS ou CMOS ayant des composants supplémentaires incorporés au sein d'un pixel ou connectés à un groupe de pixels au sein d'une matrice de capteurs, p.ex. mémoires, convertisseurs A/N, amplificateurs de pixels, circuits communs ou composants communs
• H04N 5/355 - Réglage de la gamme dynamique
• H01L 27/146 - Structures de capteurs d'images
• H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche

Abrégé

The invention features a cuff device comprising a support having a first end, a second end and an elongated body in between; connection means for electrical, magnetic and/or fluidic magnetic connection with external devices; at least one of i) an electrode and/or electronic component operatively connected with said connection means configured to electrically interface with a biological tissue and ii) a channel having an inlet, an outlet and an elongated body in between operatively connected with said connection means via said inlet and configured to fluidically interface with a biological tissue via said outlet; and at least one buckle configured to receive said first end and permit the sliding therein of said elongated body so to close and lock the cuff electrode device at desired positions, characterized in that said support is stretchable.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

Polypeptides useful in the preparation of vaccine compositions against RSV are provided. Also disclosed are methods of enhancing subdominant antibody responses in a subject.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification

Abrégé

An ophthalmic illumination and imaging system with transscleral/transpalpebral illumination of the eye fundus comprises a light-delivering device with a plurality of emitting areas; each of the emitting areas being configured to be independently controllable and directed towards the sclera of the intended eye to measure, providing transscleral oblique illumination of the eye fundus; an active eye aberration correcting system; and an imaging system configured to create multiple images of the eye fundus on multiple imaging sensors.

Classes IPC  ?

• A61B 3/12 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p.ex. ophtalmoscopes
• A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil

Abrégé

An electric vehicle (EV) charging method which considers the EVs heterogeneity, taking into account the absence of any information about future arrivals and departures, and of the amount of time any charging will take. The method further considers both switch on and off possibilities and not an arbitrarily small minimum charging power. In order to achieve all these objectives, the invention defines novel metrics and uses them to construct a dedicated optimization problem. As the charging power is discontinuous, the minimum charging power not being arbitrarily small, the optimization problem is mixed integer by nature. Further, because the mixed-integer optimization is difficult to perform in real-time, the invention proposes a heuristic for reducing the number of integer variables, thus reducing the complexity of the problem.

Classes IPC  ?

• B60L 53/64 - Optimisation des coûts énergétiques, p.ex. en répondant aux tarifs d'électricité
• B60L 53/65 - Surveillance et commande des stations de charge impliquant l'identification des véhicules ou de leurs types de batteries
• B60L 53/53 - Batteries
• B60L 58/16 - Procédés ou agencements de circuits pour surveiller ou commander des batteries ou des piles à combustible, spécialement adaptés pour des véhicules électriques pour la surveillance et la commande des batteries en fonction du vieillissement de la batterie, p.ex. du nombre de cycles de charge ou de l'état de santé [SoH]

Abrégé

The present invention relates to a method for inducing ground consolidation. The method comprises providing a first chamber in a first hole in the ground, and a second chamber in a second hole in the ground, the first and second chambers being liquid-impermeable and electrically conductive; providing a first electrolytic fluid in the first chamber and a second electrolytic fluid in the second chamber; placing at least a first electrode in the first chamber, and at least a second electrode in the second chamber, the first and second electrodes being operatively connected to a power supply; feeding consolidation fluids into the ground for feeding reactants of a consolidation process, and catalysers for the reactants into the ground; and applying to the first and second electrodes an electric current. The current causes the first electrode to operate as an anode and the second electrode to operate as a cathode thereby inducing electric polarization in the ground to cause the reactants and catalysers to cross paths to thereby cause consolidation of the ground.

Classes IPC  ?

• E02D 3/11 - Amélioration ou conservation du sol ou de la roche, p.ex. conservation du permagel par des moyens thermiques, électriques ou électro-chimiques
• E02D 3/12 - Consolidation par mise en place dans le sol de produits solidifiants ou obturant les pores
• C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
• C09K 17/42 - Composés inorganiques mélangés avec des ingrédients actifs organiques, p.ex. accélérateurs
• C12N 1/20 - Bactéries; Leurs milieux de culture
• C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p.ex. par magnétisme, par des ondes sonores
• C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques

Abrégé

The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

Classes IPC  ?

• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage