Abrégé

The present invention relates to a cathepsin inhibitor comprising or consisting of Formula (I) (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) wherein (X1) is an amino acid selected from K, L, F and M; (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S, W, Y, Q and R; (X3) is an amino acid selected from R, A and L; (X4) is an amino acid selected from M, I, K, V and Y; (X5) is an amino acid selected from P, A, I, L, V, W and Y; (X6) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q; (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R; and (Y) is a Michael acceptor.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

The present invention relates to methods and compositions which provide a companion diagnostic for cancer therapy. A method for identifying and stratifying a patient or group of patients with cancer as (i) being high or low for FMRP activity, (ii) having a high or low risk prognosis, and/or (iii) being a responder or non-responder to cancer therapy, and/or (iv) having high or low immune cell infiltrated tumor.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a method for preparing a library of peptides or an isolated peptide comprising (a) releasing one or more linear dithiol peptides carrying a sulfhydryl group in the N-terminal region of the one or more peptides and being immobilized via a disulfide bridge in the C-terminal region of the one or more peptides on a solid phase from the solid phase by (i) an agent reducing the disulfide bridge, thereby releasing the one or more linear dithiol peptides from the solid phase, wherein the agent is volatile and is removable by evaporation, or (ii) a base that deprotonates the sulfhydryl group in the N-terminal region of the one or more linear dithiol peptides, thereby inducing an intramolecular disulfide exchange thereby releasing the one or more linear dithiol peptides from the solid phase in the form of one or more cyclic peptides.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C40B 50/18 - Synthèse en phase solide, c. à d. dans laquelle au moins un bloc servant à créer la bibliothèque est lié à un support solide au cours de la création de la bibliothèque; Procédés particuliers de clivage à partir du support solide utilisant un procédé particulier d'ancrage au support solide

Abrégé

The present invention relates to Use of a compound of the general formula (I), (II), (III), (IV), (V) or (VI) wherein R1 and R1', R21 and R21', R31 and R31' are the same and are hydrogen, a linear or branched C1 to C18 alkyl, a linear or branched C2 to C18 alkenyl, a linear or branched C1 to C10 alkoxy, a linear or branched C1 to C9 alkoxycarbonyl, a linear or branched C1 to C9 alkanoyloxy, aminocarbonyl, hydroxycarbonyl, a linear or branched C1 to C9 alkoxyalkyl, an unsubstituted cycloalkyl, a linear or branched C1 to C6 alkyl substituted cycloalkyl, preferably an unsubstituted cyclohexyl, an unsubstituted C6 to C12 aryl, a linear or branched C1 to C4 alkyl substituted C6 to C12 aryl, or C7 to C12 aralkyl, R2 and R2', R22 and R22', R32 and R32' are the same and are hydrogen, a linear or branched C1 to C18 alkyl, a linear or branched C1 to C9 alkoxyalkyl, or R2 and R2' form together with R1 and R1' respectively, R22 and R22' form together with R21 and R21' respectively, R32 and R32' form together with R1 and R1' respectively, a 5 or 6 membered unsaturated or saturated carbocyclic ring optionally comprising 1 or 2 oxygen atoms, X is selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, alkoxycarbonyl, aminocarbonyl, hydroxycarbonyl, a linear or branched C1 to C18 alkyl, a C1 to C18 alkenyl, a linear or branched C2 to C10 alkenyl, a sulfonate and OR50, wherein R50 is selected from the group consisting of hydrogen, a linear or branched C1 to C18 alkyl, and a linear or branched C1 to C9 alkylcarbonyl, and Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, a linear or branched C1 to C18 alkyl, a C1 to C18 alkenyl, a linear or branched C2 to C10 alkenyl, a sulfonate and OR50, wherein R50 is selected from the group consisting of hydrogen, a linear or branched C1 to C18 alkyl, and a linear or branched C1 to C9 alkylcarbonyl, R60 is selected from the group consisting of hydrogen, hydroxy and C1 to C18 alkoxy, and R61 is selected from the group consisting of hydrogen, hydroxy, C1 to C10 alkylsulfonyl-C1 to C5, and C1 to C18 alkyl as solvent, in particular as polar solvent, for chemical reactions, for recrystallizations or extractions.

Classes IPC  ?

• C07D 493/14 - Systèmes condensés en ortho
• C07H 9/04 - Acétals cycliques
• C08G 63/42 - Ethers cycliques; Carbonates cycliques; Sulfites cycliques; Orthoesters cycliques

Abrégé

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross- sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/029 - Mesure du débit de sang à la sortie du cœur, p.ex. volume éjecté par minute
• A61B 5/107 - Mesure de dimensions corporelles, p.ex. la taille du corps entier ou de parties de celui-ci
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61B 8/06 - Mesure du débit sanguin
• A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy- preserving distributed training of a global neural network model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local training dataset (DS1 to DSn) and a vector of output labels (OL1 to OLn) for training the global model. Further, it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the weights of the global model being encrypted with the collective public key. Each data provider (DP1) computes and aggregates, for each layer of the global model, encrypted local gradients (LG1) using the respective local training dataset (DS1) and output labels (OL1), with forward pass and backpropagation using stochastic gradient descent. At least one data provider homomorphically combines at least a subset of the current local gradients of at least a subset of the data providers into combined local gradients, and updates the weights of the current global model (GM) based on the combined local gradients.

Classes IPC  ?

• G06N 3/04 - Architecture, p.ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

A computer-implemented method and a distributed computer system (100) for privacy- preserving distributed training of a global model on distributed datasets (DS1 to DSn). The system has a plurality of data providers (DP1 to DPn) being communicatively coupled. Each data provider has a respective local model (LM1 to LMn) and a respective local training dataset (DS1 to DSn) for training the local model using an iterative training algorithm (IA). Further it has a portion of a cryptographic distributed secret key (SK1 to SKn) and a corresponding collective cryptographic public key (CPK) of a multiparty fully homomorphic encryption scheme, with the local and global model being encrypted with the collective public key. Each data provider (DP1) trains its local model (LM1) using the respective local training dataset (DS1) by executing gradient descent updates of its local model (LM1), and combining (1340) the updated local model (LM1') with the current global model (GM) into a current local model (LM1c). At least one data provider homomorphically combines at least a subset of the current local models of at least a subset of the data providers into a combined model (CM1), and updates the current global model (GM) based on the combined model. The updated global model is provided to at least a subset of the other data providers.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p.ex. par clés ou règles de contrôle de l’accès

Abrégé

The invention relates to virucidal compositions comprising a sialic acid (SA) moiety, pharmaceutical compositions and disinfection and/or sterilization compositions comprising thereof and uses thereof in disinfection and/or sterilization methods and in treating and/or preventing COVID-19 and other respiratory diseases caused by coronaviruses and/or influenza viruses.

Classes IPC  ?

• A61K 31/724 - Cyclodextrines
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus

Abrégé

A composite multi-layer textile (1), comprising at least one nanofibre layer (11) with nanofibres with diameters below 100nm and one support layer (12) with microfibres with diameters below three microns, wherein the layers (11, 12) were produced by electrospinning and the multi-layer textile (1) shows a general transmittance (T%) at ? = 550 nm greater than 60%, is disclosed, which shows improved properties concerning transparency, breathability and robustness. This is achieved in that the at least one nanofibre layer (11) and the support layer (12) are fused, forming solid domains (Ds) in the multi-layer textile (1), at closed areas of a pattern used in the production process, wherein the solid domains (Ds) are separated from each other or connected, showing defined shapes, with regular or irregular spatial distribution, while the fibre morphology of nanofibres of the nanofibre layer (11) and microfibres of support layer (12) is preserved on top of the open areas beside the solid domains (Ds), attaining a general transmittance greater than that given by the sum of the individual layers (11, 12).

Classes IPC  ?

• A62B 23/02 - Filtres en vue de la protection des voies respiratoires pour appareils respiratoires
• D04H 1/4382 - Fibres obtenues par étirage de film réticulé; Fibres composites; Fibres mixtes; Fibres ultrafines; Fibres pour cuir artificiel
• D04H 1/728 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes caractérisés par la méthode de formation des voiles ou couches, p.ex. par la réorientation des fibres les fibres étant disposées au hasard par électrofilage
• B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p.ex. fibres synthétiques
• B32B 3/26 - Produits stratifiés caractérisés essentiellement par le fait qu'une des couches comporte des discontinuités ou des rugosités externes ou internes, ou bien qu'une des couches est de forme générale non plane; Produits stratifiés caractérisés essentiellement par des particularismes de forme caractérisés par une couche comportant des cavités ou des vides internes
• B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
• B32B 27/12 - Produits stratifiés composés essentiellement de résine synthétique adjacente à une couche fibreuse ou filamenteuse
• D01D 5/00 - Formation des filaments, fils ou similaires

Abrégé

It is disclosed an electrical interconnection system comprising: i) an interconnection board comprising an intrinsically non elastic substrate, said substrate having a first face and an opposed second face, and at least one conductive track on and/or within at least a portion of said substrate; ii) a stretchable interconnect comprising an intrinsically elastic substrate, said substrate comprising at least one well or groove comprising at least one compliant conductive element therein, said at least one well or groove being configured to accommodate said at least one conductive track of said interconnection board; and iii) at least one bolus of an electrically conductive paste located within said at least one well or groove, configured to electrically connect said at least one compliant conductive element with said at least one conductive track.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/375 - Aménagements structurels, p.ex. boîtiers
• H01R 12/00 - Association structurelle de plusieurs éléments de connexion électrique isolés les uns des autres, spécialement conçue pour des circuits imprimés, p.ex. des cartes de circuit imprimé [PCB], des câbles plats ou à ruban ou des structures similaires géné; Dispositifs de couplage spécialement conçus pour des circuits imprimés, des câbles plats ou à ruban ou des structures similaires généralement planes; Bornes spécialement conçues pour établir le contact avec, ou pour être insérées dans des circuits imprimés, des câbles plats ou à ruban ou des structures similaires généralement planes

Abrégé

Described is a compound having the structure (I), (II) or (V), Formulae(I), (II), (V), wherein R1 is H, CH2OH or CH(OH)CH2OH; R2 is H, -OH, or CH2OH; R3 is H, -OH, or CH2OH; n is 0 or 1; p is 0 or 1; R10 is hydrogen or a hydrocarbon moiety with 1 to 20 carbon atoms, wherein each hydrogen atom of the hydrocarbon moiety may optionally be substituted with a C1-C4-alkyl group or a halogen atom; R is either ZF or Y and wherein Z is a hydrocarbon moiety with 0 to 10 carbon atoms, optionally substituted with 1 to 4 C1-C4-alkyl groups or 1 to 4 halogen atoms, and F is COOH, CH(COOH)2, COOR4, CHO, CH(CHO)2, C2H3, C2H, N3, NH2, NHR7, OH, CH(CH2OH)2, wherein R4 is a C1-C4-alkyl group and R7 is a C1-C4-alkyl group and wherein Y is hydrogen or a linear, branched or cyclic organic residue having 1 to 20 carbon atoms with the proviso that if R is Y and n is 0 at least one of R1 or R2 is not hydrogen. Also described is a method for the preparation of the compound, a polymer derived from the compound as well as a method for the preparation of the polymer.

Classes IPC  ?

• C07H 9/04 - Acétals cycliques
• C07D 493/14 - Systèmes condensés en ortho
• C08G 61/12 - Composés macromoléculaires contenant d'autres atomes que le carbone dans la chaîne principale de la macromolécule
• C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
• C08G 69/26 - Polyamides dérivés, soit des acides amino-carboxyliques, soit de polyamines et d'acides polycarboxyliques dérivés de polyamines et d'acides polycarboxyliques

Abrégé

The present invention relates to a method for producing fragments of lignin with functional groups.

Classes IPC  ?

• C07G 1/00 - Dérivés de lignine à bas poids moléculaire
• C08H 7/00 - Lignine; Lignine modifiée; Produits dérivés à haut poids moléculaire
• C08L 97/00 - Compositions contenant des matières contenant de la lignine

Abrégé

The present disclosure relates to new agents useful for anti-cancer therapy such as anti-cancer adoptive T-cell transfer (ACT) immunotherapy or immune check-point blockade therapy and related compositions, uses and methods thereof.

Classes IPC  ?

• C07K 14/54 - Interleukines (IL)
• A61K 38/20 - Interleukines
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a vaginal fluid monitoring device embedded into a feminine sanitary pad, said device comprising a stack of the following elements: An absorbent layer (100) configured to be in proximity to, and collect, a vaginal fluid; and A biosensing system (1000) in fluidic connection with said absorbent layer (100), said biosensing system (1000) comprising: A microfluidic chip (200) configured to perform an immunoassay to detect the presence and/or the concentration of at least one target biomarker comprised in a vaginal fluid; Means (300) for providing a readout of the presence and/or the concentration of said at least one target biomarker; and An electrode array (400) located along the microfluidic chip (200) configured to detect and analyze the flow of said vaginal fluid by impedance means; wherein said immunoassay is configured to detect the presence and/or the concentration of at least one target biomarker indicative of a pre-term birth (PTB) risk and/or premature rupture of membrane (PROM) risk. The invention also relates to a method for detecting at least one target biomarker comprised in a vaginal fluid.

Classes IPC  ?

• A61B 5/1468 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p.ex. par des moyens polarographiques
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
• A61F 13/42 - Garnitures absorbantes, p.ex. serviettes ou tampons hygiéniques pour application externe ou interne au corps; Moyens pour les maintenir en place ou les fixer; Applicateurs de tampons avec un indicateur ou une alarme d'humidité
• A61F 13/472 - Serviettes hygiéniques, garnitures ou couches pour incontinence spécialement adaptées pour un usage féminin
• A61F 13/84 - Accessoires, non prévus ailleurs, pour garnitures absorbantes

Abrégé

Polypeptides useful in the preparation of vaccine compositions against RSV are provided. Also disclosed are methods of enhancing subdominant antibody responses in a subject.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
• G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p.ex. relations structurelles ou fonctionnelles ou alignement de structures
• A61K 39/12 - Antigènes viraux
• A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 37/04 - Immunostimulants
• C07K 14/135 - Virus respiratoire syncytial

Abrégé

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 35/00 - Agents anticancéreux
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• G01N 33/48 - Matériau biologique, p.ex. sang, urine; Hémocytomètres

Abrégé

The invention provides for a steerable guidewire for insertion into a body cavity, characterized in that it comprises an elongated body (101) defining a longitudinally-arranged lumen (200) comprising i) a proximal end portion (100) and ii) a distal end portion (102) comprising a spatially reconfigurable portion (104) and a tip (105); a pull wire (106) located along said lumen (200) and affixed to said distal end portion (102) and to said proximal end (100); an actuation region (140) located on said proximal end portion (100) adapted to impart a tension force on the pull wire (106) resulting in a compression force to the spatially reconfigurable region (104); and an intermediate region tubular (108) element on said body (101) located between said spatially reconfigurable portion (104) and said proximal end (100).

Classes IPC  ?

• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/09 - Fils de guidage

Abrégé

The invention provides in one embodiment a heat exchanger module (1) comprising a) a flexible support (100); b) at least one tubular member (200) having its main axis substantially parallel with the plane of the flexible support (100); c) a conductive flexible matrix (300) embedding the at least one tubular member (200); and d) a flexible case (400) enwrapping the flexible support (100), the at least one tubular member (200) and the conductive flexible matrix (300). A coating for a built environment comprising a plurality of heat exchanger modules (1) can be implemented, as well as a system further including pumping means (600). The invention also foresees a method for providing heat exchange processes between the heat exchanger module (1), the coating or the system of the invention and a built environment.

Classes IPC  ?

• F24T 10/10 - Collecteurs géothermiques avec circulation des fluides vecteurs dans des conduits souterrains, les fluides vecteurs n’entrant pas en contact direct avec le sol
• F28D 21/00 - Appareils échangeurs de chaleur non couverts par l'un des groupes
• F28F 1/00 - Eléments tubulaires; Ensembles d'éléments tubulaires
• F28F 1/22 - Eléments tubulaires ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p.ex. avec des ailettes, avec des saillies, avec des évidements ces moyens étant uniquement à l'extérieur de l'élément tubulaire et s'étendant longitudinalement les moyens ayant des parties engageant d'autres éléments tubulaires
• F28F 13/00 - Dispositions pour modifier le transfert de chaleur, p.ex. accroissement, diminution
• F28F 21/06 - Structure des appareils échangeurs de chaleur caractérisée par l'emploi de matériaux spécifiés de matériau plastique

Abrégé

The invention relates to a method for degradation of plastic materials into terephthalic acid (TPA)and/or ethylene glycol and/or other monomers that form the plastic materials.

Classes IPC  ?

• C07C 29/09 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrolyse
• C07C 31/20 - Alcools dihydroxyliques
• C07C 51/09 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides à partir de lactones ou d'esters d'acides carboxyliques
• C07C 59/08 - Acide lactique
• C07C 63/26 - Acide benzènedicarboxylique-1, 4
• C08L 31/08 - Homopolymères ou copolymères des esters d'acides polycarboxyliques de l'acide phtalique

Abrégé

The invention relates to virucidal nanoparticles comprising a trisaccharide moiety and use thereof against influenza virus.

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/61 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique le composé organique macromoléculaire étant un polysaccharide ou l’un de ses dérivés
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus

Abrégé

In a composite material (6), comprising a fibrous reinforcement (3), and a polymer matrix (14), wherein the polymer matrix (14) comprises two interpenetrating phases, namely a thermoset phase and a continuous thermoplastic phase, wherein the thermoset phase and the thermoplastic phase form a matrix microstructure (7), wherein the matrix microstructure (7) comprises a thermoplastic matrix formed by the thermoplastic phase, and wherein the matrix microstructure (7) comprises a multitude of thermoset particles (13) formed by the thermoset phase, the thermoset particles (13) have dimensions in a range between 0.1 µm and 10 µm.

Classes IPC  ?

• C08J 5/04 - Renforcement des composés macromoléculaires avec des matériaux fibreux en vrac ou en nappes
• C08J 5/24 - Imprégnation de matériaux avec des prépolymères pouvant être polymérisés en place, p.ex. fabrication des "prepregs"

Abrégé

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prevention and/or treatment of neurological disorders, in particular neurodegenerative and psychiatric disorders or improving cognitive and memory functions.

Classes IPC  ?

• C07D 217/22 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle contenant l'azote
• A61K 31/472 - Isoquinoléines non condensées, p.ex. papavérine
• A61P 25/16 - Antiparkinsoniens
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• C07D 217/02 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle contenant l'azote; Alkylène-bis-isoquinoléines

Abrégé

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

Classes IPC  ?

• C09B 23/01 - Colorants méthiniques ou polyméthiniques, p.ex. du type cyanine caractérisés par la chaîne méthinique
• A61K 49/00 - Préparations pour examen in vivo
• G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées

Abrégé

The present invention concerns a method of displaying an image on a see-through display. The method comprises: obtaining (101) a first electromagnetic radiation matrix of an object, the first matrix comprising first matrix elements representing radiation intensity values of corresponding locations of the object; dividing (103) the first matrix into a second matrix representing a first subset of the radiation intensity values of the matrix elements, and a third, different matrix representing a second, different subset of the radiation intensity values of the matrix elements; generating (105) a first histogram for the second matrix; equalising (107) the first histogram to obtain an equalised second histogram; generating (109) a first grayscale image representing the first subset of the radiation intensity values from the second matrix and the equalised second histogram; colouring (111) the first grayscale image with a first colourmap to obtain a first colour image; generating (113) a second grayscale image representing the second subset of the radiation intensity values image by mapping substantially linearly the second subset of the radiation intensity values to a given number of encoded radiation intensity values; colouring (115) the second grayscale image with a second colourmap, which is different from the first colourmap, to obtain a second colour image; combining (117) the first colour image and the second colour image to obtain a combined colour image; and displaying (123) the combined colour image on the see-through display.

Classes IPC  ?

• G06T 5/40 - Amélioration ou restauration d'image en utilisant des techniques d'histogrammes

Abrégé

A steerable device for use as e.g. a guidewire for insertion into a subject's body is disclosed. The device features a single side deflection of a bendable portion located at its distal end by application of a longitudinally-directed force either on an inner pull wire or on said bendable portion. The bendable portion is characterized by the presence of a reinforcement structure on one lateral side and a stress relief portion on the opposed lateral side that, upon actuation of the device, allows single side bending thanks to the physical constriction of the reinforcement structure, limiting the compression of one side of the bendable portion. A system further comprising an actuator, as well as methods for using thereof, are also disclosed.

Classes IPC  ?

• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/09 - Fils de guidage

Abrégé

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

Classes IPC  ?

• A61K 9/06 - Onguents; Excipients pour ceux-ci
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/50 - Microcapsules
• A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes ; Leurs dérivés
• C08L 5/04 - Acide alginique; Ses dérivés

Abrégé

The invention relates to virucidal compounds, virucidal compositions comprising thereof and uses thereof in treatment of viral infections, for sterilizations and for disinfections. The compounds are sulfonylalkylcyclodextrins.The virucidal compounds can be of formula (I):(I)whereinx is 6, 7 or 8R is -Z-CH2-(CH2)y-SO3'Z is O or Sy is at least 4R'is selected from the group comprising H, -(CfhX-SOs', -(CH2)-C00H, polymer or other water solubilising group.

Classes IPC  ?

• A61K 31/724 - Cyclodextrines
• A61P 31/12 - Antiviraux
• C08B 37/16 - Cyclodextrine; Ses dérivés

Abrégé

A radiopaque composition with low viscosity and increased photopolymerizability for application or filling of hollow structures is disclosed. Moreover, a method to apply and monitor the application and/or the photopolymerization of the composition are presented.

Classes IPC  ?

• A61L 24/00 - Adhésifs ou ciments chirurgicaux; Adhésifs pour dispositifs de colostomie
• A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
• A61C 5/00 - Obturation ou recouvrage des dents

Abrégé

The invention provides for a device (100) for use in electrical nerve modulation in a subject, characterized in that it comprises a rotational and linear actuator (110); a tubular element (101) having a proximal end connected to the actuator (110) and a distal end; a flexible shaft (102) coaxially disposed within the tubular element (101), comprising a proximal end operably connected to the actuator (110) and a distal end, and adapted to be slid along the tubular element (101); a conformable support (103) comprising a proximal end operably connected to the tubular element's (101) distal end, and a distal end operably connected to the flexible shaft's (102) distal end, having a portion of its length helically wrapped about a distal portion of the flexible shaft (102) so to define a pitch (500) and a radius (400); and a plurality of electrodes (104) operably disposed along the helically configured portion of the conformable support (103), and electrically connectable to a generator (200), adapted to contact the endoluminal surface of a blood vessel of the subject and deliver electrical energy; wherein the pitch (500), radius (400) or both of the helically configured portion of the conformable support (103) can be modified via actuator's (110) driven extension, retraction and/or rotation of the flexible shaft (102).

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61B 18/14 - Sondes ou électrodes à cet effet
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci

Abrégé

The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Classes IPC  ?

• C07C 41/01 - Préparation d'éthers
• C08H 7/00 - Lignine; Lignine modifiée; Produits dérivés à haut poids moléculaire
• C07C 43/23 - Ethers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
• C07G 1/00 - Dérivés de lignine à bas poids moléculaire
• C07H 9/04 - Acétals cycliques
• D21C 11/00 - Régénération des liqueurs noires

Abrégé

The invention provides ionic polymers (IP) consisting of anions and a polymeric backbone containing cations. The invention also provides the ionic polymers incorporated in membranes or attached to solid supports and use of the ionic polymers in processing of biomass.

Classes IPC  ?

• C08F 12/26 - Azote
• C08F 12/30 - Soufre
• C08F 212/14 - Monomères contenant un seul radical aliphatique non saturé contenant un cycle substitué par des hétéro-atomes ou des groupes contenant des hétéro-atomes
• C08F 212/34 - Monomères contenant plusieurs radicaux aliphatiques non saturés
• C13K 1/02 - Glucose; Sirops glucosés obtenus par saccharification de matières cellulosiques
• D21C 5/00 - Autres procédés pour obtenir de la cellulose, p.ex. cuisson des linters de coton

Abrégé

The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to enhance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to vectors or antigen presenting cells expressing said receptors, composition and uses thereof for the prevention and/or treatment of a cancer.

Classes IPC  ?

• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 16/32 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes

Abrégé

Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 38/28 - Insulines
• A61K 39/35 - Allergènes

Abrégé

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
• A61L 27/00 - Matériaux pour prothèses ou pour revêtement de prothèses

Abrégé

2-homopiperazine-1-yl-4H-l, 3 -bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2- (homo)piperazine 1, 3-benzothiazine-4-one hydrochlorides is also provided.

Classes IPC  ?

• C07D 279/08 - Thiazines-1, 3; Thiazines-1, 3 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques
• A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p.ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p.ex. phénothiazine, chlorpromazine, piroxicam
• A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p.ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p.ex. clozapine, dilazèpe
• A61P 31/04 - Agents antibactériens
• C07D 281/02 - Cycles à sept chaînons

Abrégé

The invention concerns a device (1) for aggregating cells comprising at least one cavity (2), wherein said cavity comprises a plurality of microwells (3) for receiving at least one cell, wherein each said well comprises a vertical sidewall and a curved bottom.

Classes IPC  ?

• C12M 1/22 - Boîtes de Pétri
• C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

Gas sensor (2) for measuring properties of a gas (1), including a gas viscosity sensor (4) comprising a gas interface portion (20) in contact with the gas (1) to be measured, and a measuring chamber system (15) comprising a measuring chamber(16), a first resistive passage (18) fluidically connecting the measuring chamber (16) to the gas interface portion (20), a pressure generator (25) configured to generate a change in pressure in the measuring chamber, and a pressure sensor (28) configured to measure a time dependent variation in pressure of gas in the measuring chamber, the time dependent variation of pressure in the measuring chamber due to flow of gas through the resistive passage being correlated to a viscosity of the gas. The gas viscosity sensor further comprises a reference chamber system (21) comprising a reference chamber and a second resistive passage (24) fluidically interconnecting the reference chamber (22) to the gas interface portion (20), the reference chamber (22) being coupled to the pressure sensor (28) of the measuring chamber such that the pressure sensor is configured to measure a differential pressure between a pressure in the measuring chamber and a pressure in the reference chamber.

Classes IPC  ?

• G01N 33/22 - Combustibles; Explosifs
• G01N 7/10 - Analyse des matériaux en mesurant la pression ou le volume d'un gaz ou d'une vapeur en permettant la diffusion des constituants à travers une cloison poreuse et en mesurant une différence de pression ou de volume
• G01N 11/04 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p.ex. un tube, une ouverture

Abrégé

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

Classes IPC  ?

• A61K 39/02 - Antigènes bactériens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a proteinaceous moiety tethered to a synthetic regulatory molecule. Also provided is an analytical device comprising a sensor and methods using the sensor molecule.

Classes IPC  ?

• C12Q 1/66 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une luciférase
• G01N 33/542 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p.ex. extinction de fluorescence

Abrégé

Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, and vaccines.

Classes IPC  ?

• C07K 14/52 - Cytokines; Lymphokines; Interférons
• A61K 47/66 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé l’agent de modification étant un système de pré-ciblage impliquant un peptide ou une protéine pour cibler des cellules spécifiques
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 19/00 - Médicaments pour le traitement des troubles du squelette
• A61P 37/04 - Immunostimulants
• C07K 14/475 - Facteurs de croissance; Régulateurs de croissance
• C07K 19/00 - Peptides hybrides

Abrégé

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyses. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61H 3/00 - Appareils pour aider des personnes handicapées à marcher
• A61F 5/00 - Procédés ou dispositifs d'orthopédie pour le traitement non chirurgical d'os ou articulations; Dispositifs pour donner des soins

Abrégé

A biological and chemical sample processing device that b. comprises a high pressure-resistant, shallow and wide area microfluidic chamber having at least one wall formed by a detachable slide containing samples such as immobilized entities, biological samples or molecules, c. comprises an arrangement of microfluidic access holes for injecting to and collecting fluid form said chamber, d. is interfaced with inlet ports and microfluidic channels which are formed external to the chamber, e. is configured so that the slide may be brought into contact with the device to form the said chamber, f. is adapted to deliver and to transport fluidic substances and reagents inside said chamber in a fast manner, preferably within less than 15 seconds, and in a regular or uniform way owing to said arrangement of microfluidic access holes.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

The present invention relates to use of a compound of fommla II having Notch signalling pathway inhibition properties in treating and/or preventing cancers.

Classes IPC  ?

• A61K 31/4412 - Pyridines non condensées; Leurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/136 - Amines, p.ex. amantadine ayant des cycles aromatiques, p.ex. méthadone ayant le groupe amino lié directement au cycle aromatique, p.ex. benzène-amine
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to new 2-piperazin-1-yl-4H-1,3-benzothiazin- 4-one derivatives and their use for the treatment of mammalian infections caused by bacteria, especially diseases like tuberculosis (TB), Buruli ulcer and leprosy that result from infection with closely related mycobacteria. (I).

Classes IPC  ?

• C07D 279/08 - Thiazines-1, 3; Thiazines-1, 3 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques
• A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p.ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p.ex. phénothiazine, chlorpromazine, piroxicam
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose

Abrégé

Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 9/127 - Liposomes
• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• C07K 14/755 - Facteurs VIII
• C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C07K 19/00 - Peptides hybrides

Abrégé

Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque

Abrégé

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an supportive backing layer. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as along a region of a cortex of a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• B81C 3/00 - Assemblage de dispositifs ou de systèmes à partir de composants qui ont reçu un traitement individuel
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localised and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an supportive backing layer. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as along a region of a cortex of a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or simulation.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61B 5/291 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques

Abrégé

A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.

Classes IPC  ?

• G01N 21/05 - Cuvettes à circulation de fluides
• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term moni-toring and/or stimulation.

Classes IPC  ?

• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque

Abrégé

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.

Classes IPC  ?

• A61K 9/16 - Agglomérés; Granulés; Microbilles
• A61K 9/127 - Liposomes
• A61P 35/00 - Agents anticancéreux
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques

Abrégé

A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a micro-electrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape. A target can be identified by microelectrode measurements of neuronal activity and/or impedance magnitude at peak resistance frequency.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p.ex. stimulateurs cardiaques
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication

Abrégé

The present invention relates to a method of producing hydrogen gas and carbon dioxide in a catalytic reaction from formic acid, said reaction being conducted in an aqueous solution over a wide temperature range and already at room temperature (25°C). The reaction is advantageous because it can be tuned to take place at very high rates, up to about 90 litre H2 / minute / litre reactor volume. The gas produced is free of carbon monoxide. The method of the present invention is particularly suitable for providing hydrogen for a motor, fuel cell or chemical synthesis.

Classes IPC  ?

• C01B 3/22 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés organiques gazeux ou liquides
• B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine

Abrégé

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• A61P 37/04 - Immunostimulants

Abrégé

The disclosed method and system may be used for creating advanced protection means for various categories of documents (e.g. bank notes, identity documents, certificates, checks, diploma, travel documents, tickets) and valuable products (e.g. optical disks, CDs, DVDs, CD-ROMs, prescription drugs, products with affixed labels, watches) hereinafter called "secure items". Secure items are authenticated by shape level lines. The shape level lines become apparent when superposing a base layer comprising sets of lines and a revealing layer comprising a line grating. One of the two layers is a modified layer which embeds a shape elevation profile generated from an initial, preferably bilevel, motif shape image (e.g. typographic characters, words of text, symbols, logo, ornament). In the case of an authentic document, the outline of the revealed shape level lines are visual offset lines of the boundaries of the initial bilevel motif shape image. In addition, the intensities, respectively colors of the revealed shape level lines are the same as the intensities, respectively colors of the lines forming the base layer sets of lines. By modifying the relative superposition phase of the revealing layer on top of the base layer or vice-versa (e.g. by a translation or a rotation), one may observe shape level lines moving dynamically between the initial bilevel motif shape boundaries and shape foreground centers, respectively background centers, thereby growing and shrinking. In the case that these characteristic features are present, the secure item is accepted as authentic. Otherwise the item is rejected as suspect. Pairs of base and revealing layers may be individualized by applying to both the base and the revealing layer a geometric transformation. Thanks to the availability of a large number of geometric transformations and transformation parameters, one may create documents having their own individualized document protection. The invention also proposes a computing and delivery system operable for delivering base and revealing layers according to security document or valuable product information content. The system may automatically generate upon request an individually protected secure item and its corresponding authentication means.

Classes IPC  ?

• G07D 7/20 - Vérification de motifs des papiers
• B42D 25/342 - Effets moirés

Abrégé

The present invention relies on a band moiré image layout model capable of predicting the band moiré image layer layout produced when superposing a base band grating layer of a given layout and revealing line grating layer of a given layout. Both the base band grating layer and the revealing line grating layer may have a rectilinear or a curvilinear layout. The resulting band moiré image layout may also be rectilinear or curvilinear. Thanks to the band moiré image layout model, one can choose the layout of two layers selected from the set of base band grating layer, revealing line grating layer and band moiré image layer and obtain the layout of the third layer by computation, i.e. automatically. A computing system may automatically generate upon request an individualized protected security document having specific base band grating and revealing line grating layouts.

Classes IPC  ?

• B42D 15/00 - Cartes ou imprimés d'un format ou d'un type particulier non prévu ailleurs