Disclosed are immunogenic compositions and vaccines containing rationally designed coronavirus Spike proteins and polynucleotides encoding the same that can be administered to treat or inhibit a coronavirus infection. The compositions and vaccines can also be used to produce anti-coronavirus antibodies (e.g., broadly neutralizing anti-coronavirus antibodies), which can also be used for prophylactic or therapeutic purposes in the treatment of a coronavirus infection.
A61K 39/215 - Coronaviridae, p.ex. virus de la bronchite infectieuse aviaire
C12N 15/75 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p.ex. Lactobacillus, Micromonospora pour Bacillus
2.
HIV VACCINE IMMUNOGENS FOR THE INDUCTION OF V3-GLYCAN TARGETING ANTIBODIES
The invention is directed to modified HIV-1 envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-1 envelopes and/or these nucleic acids to induce immune responses.
Provided herein are novel monoclonal antibodies and antibody fragments with improved binding to and/or neutralization against multiple SARS-CoV-2 variants, e.g., Omicron lineages. Also provided are compositions and biosensors comprising the monoclonal antibodies and antibody fragments and methods of using the novel monoclonal antibodies and antibody fragments for treating, preventing, and diagnosing COVID-19 and detecting SARS- CoV-2.
C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61P 31/14 - Antiviraux pour le traitement des virus ARN
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A structure including a substrate and a coating over the substrate is acoustically excited to measure acoustic response in the structure. The measured acoustic response in the structure is filtered to remove acoustic response of the substrate and determine acoustic response of the coating. The acoustic response of the coating is used to inspect the coating for failure.
Different frequencies for steady state excitation of the structure may be tested by sweeping over an excitation frequency range. Partial measurements of the responses in the structure at different excitation frequencies may be used to select excitation frequencies, and the selected excitation frequencies may be used to inspect the structure.
G06Q 50/00 - Systèmes ou procédés spécialement adaptés à un secteur particulier d’activité économique, p.ex. aux services d’utilité publique ou au tourisme
6.
DEVELOPMENT OF MOSAIC VACCINES AGAINST FOOT AND MOUTH DISEASE VIRUS SEROTYPE O
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF AGRICULTURE (USA)
TRIAD NATIONAL SECURITY, LLC (USA)
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventeur(s)
Rieder, Aida E.
Pflaum, Katherine M.
Diaz San Segundo, Fayna C.
Fischer, William M.
Sitt, Tatjana
Abrégé
Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of and FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune response that provide protection against a broad range of serotype O FMDV strains.
A method includes acoustically exciting a rotating component over a range of frequencies. The method further includes measuring the resulting frequency response of the rotating component in response to the acoustic excitation. The method also includes processing the frequency response to determine whether a frequency response has shifted in comparison a prior frequency response. The method includes determining an amount of wear and tear of the rotating component based on the determined shift in the frequency response.
G01N 29/44 - Traitement du signal de réponse détecté
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonores; Visualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
G01N 29/30 - Dispositions pour l'étalonnage ou la comparaison, p.ex. avec des objets standard
G01N 29/46 - Traitement du signal de réponse détecté par analyse spectrale, p.ex. par analyse de Fourier
A system includes an acoustic transmitter, an acoustic receiver, a memory component, and a processor. The acoustic transmitter transmits an acoustic signal into a material with an unknown moisture level and changes into an acoustic response signal after passing through the material. The acoustic receiver receives the acoustic response signal associated with the material with the unknown moisture level. The memory component stores data comprising moisture levels associated with acoustic speeds of acoustic response signals. The processor is coupled to the acoustic receiver and to the memory and determines a speed of the acoustic response signal associated with the material with the unknown moisture level, and further determines an actual moisture level of the unknown moisture level of the material by associating the speed of the acoustic response signal associated with the material with the unknown moisture level to the data in the memory component.
G01N 19/10 - Mesure de la teneur en eau, p.ex. par mesure de la variation de la longueur d'un filament hygroscopique; Hygromètres
G01H 5/00 - Mesure de la vitesse de propagation des ondes ultrasonores, sonores ou infrasonores
G01H 17/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores non prévue dans les autres groupes de la présente sous-classe
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, WASHINGTON, DC (USA)
TRIAD NATIONAL SECURITY, LLC (USA)
Inventeur(s)
Glaros, Trevor
Mach, Phillip
Caprioli, Richard
Norris, Jeremy
Abrégé
Systems and devices are disclosed to generate a multidimensional mass fingerprint that allows for identification on a low-resolution mass spectrometer equipped with post-ionization fragmentation. For this approach, rather than interrogating a sample that is processed into peptides using a single high resolution MS scan as in traditional fingerprinting, a raw unprocessed sample (containing all biochemical species; lipids, proteins, peptides, and metabolites) is analyzed by combining Matrix-Assisted Laser Dissociation/Ionization (MALDI) ionization with low resolution tandem mass spectrometry. The proposed system combines improvements in MS hardware and software with state-of-the-art machine learning (ML) approaches to usher in rapid biological detection. This technique does not require any prior separation (liquid or gas chromatography) and is therefore rapid (e.g. less than 5 sec) and amenable to high throughput (e.g. greater than 384 samples/hr).
Disclosed are immunogenic compositions and vaccines containing rationally designed coronavirus Spike proteins and polynucleotides encoding the same that can be administered to treat or inhibit a coronavirus infection. The compositions and vaccines can also be used to produce anti-coronavirus antibodies (e.g., broadly neutralizing anti-coronavirus antibodies), which can also be used for prophylactic or therapeutic purposes in the treatment of a coronavirus infection.
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
A system for detecting cracks in an underwater structure can include an acoustic signal transmitter configured to be disposed proximate to, but without physically contacting, the underwater structure, where the acoustic signal transmitter is configured to emit acoustic signals. The system can also include an acoustic field receiver configured to be disposed proximate to, but without physically contacting, the underwater structure, where the acoustic field receiver is configured to receive resulting acoustic fields. The system can further include a controller that is configured to receive the resulting acoustic fields from the acoustic field receiver. The controller can also be configured to analyze the resulting acoustic fields signal. The controller can further be configured to detect, based on analyzing the resulting acoustic fields, a crack in the underwater structure.
G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonores; Visualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
12.
POROUS CARBON MATERIALS, NANOPARTICLES, METHODS OF MAKING SAME, AND USES THEREOF
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
TRIAD NATIONAL SECURITY, LLC (USA)
Inventeur(s)
Wu, Gang
Qiao, Zhi
Spendelow, Jacob
Wang, Chenyu
Li, Dongguo
Pan, Yung-Tin
Abrégé
Provided are graphitic carbon materials and methods of making graphitic carbon materials. Also provided are compositions of the graphitic carbon materials with nanoparticles disposed thereon and methods of making the compositions. Also disclosed are devices utilizing the graphitic carbon materials and/or the compositions. The graphitic carbon materials are porous and have a desirable graphitic content. The graphitic materials may be nitrogen- and/or metal-doped. The nanoparticles may be platinum or platinum/transition metal nanoparticles. The compositions may be used in oxygen reduction reaction applications.
The invention is directed to mosaic human immunodeficiency virus HIV-1 envelopes, and methods of using the same to induce Antibody (Ab)-dependent cellular cytotoxicity (ADCC) responses. Specifically, the disclosure provides new mosaic HIV-1 envelope designs, selection of HIV-1 envelopes and combinations thereof; methods of using these envelopes to induce antibody protective responses, wherein the protective responses are associated with ADCC activity. Further provided are mosaic HIV-1 envelope sequences, and a pharmaceutical composition comprising a polypeptide of any one of the envelopes or a nucleic acid encoding any one of the envelopes disclosed.
A61K 39/21 - Retroviridae, p.ex. virus de l'anémie infectieuse équine
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
14.
METHOD FOR PROCESSING INSAR IMAGES TO EXTRACT GROUND DEFORMATION SIGNALS
PARIS SCIENCES ET LETTRES - QUARTIER LATIN (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
TRIAD NATIONAL SECURITY, LLC (USA)
Inventeur(s)
Jolivet, Romain
Rouet-Leduc, Bertrand
Johnson, Paul
Hulbert, Claudia
Dalaison, Manon
Abrégé
The invention relates to a method for processing time series of noisy images of a same area, the method comprising: generating a set of time series of images from an input image time series (RI[t]) by combining by first linear combinations each pixel (PX[i,j]) of each image of the input image time series with selected neighboring pixels in the image and in an adjacent image of the input image time series; applying filtering operations (FPs, s=1-3, 5, 7-11) in cascade to the set, each filtering operation combining each pixel of each image of each time series of the set by second linear combinations with selected neighboring pixels in the image and in an adjacent image in each time series of the set; performing an image combination operation (SLs, s=4, 6) to reduce each time series of the set to a single image; introducing a model image (EM) of the area as a filtered image in the set; and combining each image in the set into an output image (PI), by third linear combinations.
The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV) vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.
Combinations of multiple analytic techniques may be used to identify changes to a structure based on changes in characteristics of acoustic signals traveling along the structure. Acoustic signals traveling along the structure may be monitored to detect changes in characteristics of the acoustic signal from baseline signal characteristics. The changes in characteristics of the acoustic signals may be processed using multiple analytic techniques to provide analyses of the change in time-domain, in frequency-domain, and in mixed time-frequency-domain. The change to the structure may be identified based on a combination of the results of the analysis in time-domain, in frequency-domain, and in mixed time-frequency-domain.
G01N 29/00 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonores; Visualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet
Various embodiments of the disclosure provide methods using spark plasma sintering (SPS) at moderate temperatures and moderate pressures to fabricate high-density graphite material. The moderate temperatures may be temperatures not exceeding about 1200°C. The moderate pressures may be pressures not exceeding about 300 MPa. The high-density exhibited by the resulting, sintered, high-density graphite material may be greater than about 1.75 g/cm3e.g.e.g., greater than about 2.0 g/cm3).
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
19.
SYSTEMS AND METHODS FOR MODELING SUBSTANCE CHARACTERISTICS
Structure information for a substance within a volume may be obtained. The structure information may characterize structural non-linearity of the substance within the volume. A structure model for the substance within the volume may be generated based on the structure information and/or other information. The structure model may simulate one or more characteristics of the substance within the volume. Presentation of information on the characteristic(s) of the substance within the volume may be effectuated based on the structure model and/or other information.
G01N 21/31 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
G01N 21/27 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
20.
REAL-WORLD NETWORK LINK ANALYSIS AND PREDICTION USING EXTENDED PROBAILISTIC MAXTRIX FACTORIZATION MODELS WITH LABELED NODES
A practical adaptation and application of a Poisson matrix factorization (PMF) model for binary matrices to scenarios encountered in real-world computer networks is disclosed. Link prediction techniques may extend the PMF model by incorporating node-specific covariates for two sets of nodes in the PMF framework, modeling sparsity on both latent feature matrices, and/or accounting for seasonal effects to predict links. The standard PMF model may therefore be extended in three directions, which may all be implemented simultaneously to produce more accurate inference and prediction. Furthermore, the model may be extended to properly deal with binary edges, where only the existence of an edge is observed rather than an associated count along the edge.
Processes for determining whether new subgraphs that are observed locally in dynamic graphs are indicative of anomalous behavior are disclosed. Community models including certain factors, such as the rate of creation of new subgraphs of given structures and labels, may provide a basis for measuring the likelihood of newly observed subgraphs. For instance, edge labels including attributes for these specific shapes, such as port numbers and/or other categories, may differentiate legitimate new local occurrences thereof from those that are anomalous. Such processes may have applications including anomaly detection in computer networks, distributed systems, other patterns of life applications including dynamic graphs (e.g., dynamic directed multi graphs), etc.
Methods for detection, monitoring, and determination of location of changes in rigid structures with arbitrarily complex geometries are described. Implementations include locating acoustic transducers that generate and receive acoustic signals at multiple locations along a surface of the rigid structure, wherein longitudinal spacing between the transducer locations define measurement zones. Acoustic signals with chosen amplitude-time-frequency characteristics excite multiple vibration modes in the structure within each zone. Small mechanical changes in the inspection zones lead to scattering and attenuation of broadband acoustic signals, which are detectable as changes in received signal characteristics as part of a through-transmission technique. Additional use of short, narrowband pulse acoustic signals as part of a pulse-echo technique allows determination of the relative location of the mechanical change within each zone based on the differential delay profiles.
G01N 29/11 - Analyse de solides en mesurant l'atténuation des ondes acoustiques
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonores; Visualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
G10K 11/00 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son en général; Procédés ou dispositifs de protection contre le bruit ou les autres ondes acoustiques ou pour amortir ceux-ci, en général
23.
NONINVASIVE ACOUSTICAL PROPERTY MEASUREMENT OF FLUIDS
Methods for noninvasive determination of acoustical properties of flowing in pipes having a large ratio (>10) of pipe diameter to wall thickness, and in highly attenuating fluids are described. When vibrations are excited on the outer surface of the wall of a pipe, the resulting vibrations propagate directly through the wall In a normal direction and through the pipe wall as guided waves, appearing on the opposite side of the pipe. This dual path propagation through pipes, where guided waves take the circumferential path in the wall of the pipe and may interfere with the time of-flight measurement obtained from the direct path through the fluid, is at least In part resolved by subtracting the signal from the guided wave from the combined signal, thereby permitting improved observation of the direct path propagation through the fluid.
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p.ex. en utilisant des débitmètres à ultrasons
brevets
