Abrégé

The present disclosure relates to IgA antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The present disclosure also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 14/18 - Togaviridae, p.ex. flavivirus, virus de la peste, virus de la fièvre jaune, virus de l'hépatite C, virus de l'encéphalite japonaise

Abrégé

The present disclosure is directed to monoclonal antibodies, or antigen-binding fragments thereof, that bind to coronavirus spike proteins, including the spike protein of SARS-CoV-2. These antibodies demonstrate high affinity binding to epitopes on the coronavirus spike protein and/or broad cross-reactivity to the spike protein of various coronaviruses. Compositions comprising the anti-coronavirus antibodies, nucleic acids encoding for the antibodies, recombinant expression vectors, and host cells are also disclosed. The present disclosure is also directed to methods of diagnosing, preventing or treating coronavirus infections, including infections or disease caused by SARS-CoV-2.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/42 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 16/46 - Immunoglobulines hybrides
• C12N 15/13 - Immunoglobulines

Abrégé

A thermogenic emergency airway management device configured to prevent or treat hypothermia in a patient. The device may be configured to receive ambient air and modify one or more properties of the ambient air to output air at a temperature and/or humidity associated with the prevention and/or treatment of hypothermia. In an embodiment, the device may receive input via a user interface to determine a temperature and/or humidity associated with the air to be output to the patient. In an embodiment, the input may additionally include an amount of air to be output to be the patient. In such an embodiment, the device may be configured to cause the amount of air to be output to the patient to prevent and/or treat hypothermia.

Classes IPC  ?

• A61M 16/10 - Préparation de gaz ou vapeurs à respirer
• A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents
• A61M 16/20 - Valves spécialement adaptées aux dispositifs respiratoires médicaux

Abrégé

Provided are cathepsin inhibitor compounds and pharmaceutically acceptable salts thereof, and combinations thereof, for use in the treatment or prophylaxis of viral disease in an animal.

Classes IPC  ?

• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p.ex. azélastine, pentylènetétrazole
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

The present disclosure relates to the field of vaccines and binding molecules, as well as preparations and methods of their use in the treatment and/or prevention of disease. Described are vaccines and binding molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections, in particular, ?-coronaviruses such as SARS- CoV-2, the causative agent of COVID-19, as well as SARS-CoV-1 and other coronaviruses.

Classes IPC  ?

• A61K 39/215 - Coronaviridae, p.ex. virus de la bronchite infectieuse aviaire

Abrégé

Described is the preparation of novel fentanyl haptens of Formula (1) through (6) and their use in the preparation of effective fentanyl vaccines.

Classes IPC  ?

• C07D 211/06 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle  ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• A61K 31/4468 - Pipéridines non condensées, p.ex. pipérocaïne ayant un atome d'azote lié directement en position 4, p.ex. clébopride, fentanyl
• A61P 25/36 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance aux opiacés
• C07D 211/58 - Atomes d'azote liés en position 4

Abrégé

A therapeutic hemoglobin-based oxygen carrier solution is formed by directly combining at least one of freeze-dried platelets and freeze-drug plasma with a hemoglobin-based oxygen carrier. The therapeutic hemoglobin-based oxygen carrier solution can be employed to treat bleeding or anemia and simultaneously increase systemic convective oxygen delivery in a subject suffering low circulatory oxygen transport or bleeding.

Classes IPC  ?

• A61K 38/42 - Hémoglobines; Myoglobines
• A61K 35/19 - Plaquettes; Mégacaryocytes
• A61K 35/16 - Plasma sanguin; Sérum sanguin
• A61K 47/02 - Composés inorganiques
• A61K 47/12 - Acides carboxyliques; Leurs sels ou anhydrides
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
• A61P 7/04 - Antihémorragiques; Profacteurs de coagulation; Agents hémostatiques; Agents antifibrinolytiques
• A61P 7/06 - Antianémiques
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p.ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénal

Abrégé

The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/42 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
• C07K 16/46 - Immunoglobulines hybrides
• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
• C12N 15/13 - Immunoglobulines
• C12P 21/08 - Anticorps monoclonaux
• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
• C07K 14/18 - Togaviridae, p.ex. flavivirus, virus de la peste, virus de la fièvre jaune, virus de l'hépatite C, virus de l'encéphalite japonaise

Abrégé

Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components.

Classes IPC  ?

• C22C 21/00 - Alliages à base d'aluminium
• E21B 23/06 - Appareils pour déplacer, mettre en place, verrouiller, libérer ou retirer, les outils, les packers ou autres éléments dans les trous de forage pour le montage des packers
• E21B 33/12 - Packers; Bouchons

Abrégé

Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV

Abrégé

A method of creating a fragmentation pattern on a warhead comprising ablating material from the interior surface of the warhead according to a pre-defined fragmentation pattern. The pre-defined fragmentation pattern may be effected electronically or with a mask. The ablation may be effected by applying an etchant to the warhead interior surface material.

Classes IPC  ?

• F42B 12/24 - Projectiles ou mines caractérisés par la charge militaire, l'effet recherché ou le matériau caractérisés par la nature de la charge militaire ou par l'effet recherché du type à explosif brisant à structure de corps de fragmentation l'enveloppe du projectile présentant des rainures, des cannelures ou d'autres affaiblissements
• F42B 12/32 - Projectiles ou mines caractérisés par la charge militaire, l'effet recherché ou le matériau caractérisés par la nature de la charge militaire ou par l'effet recherché du type à explosif brisant à structure de corps de fragmentation l'enveloppe ou la paroi du projectile contenant un ensemble de corps individuels encastrés, p.ex. de sphères en acier
• F42B 33/00 - Fabrication de munitions; Démontage de munitions; Appareils à cet effet

Abrégé

An antenna system may include a first antenna, and a second antenna opposite the first antenna, wherein the first antenna and the second antenna are configured to provide omnidirectional coverage

Classes IPC  ?

• H01Q 21/29 - Combinaisons d'unités d'antennes de types différents interagissant entre elles pour donner une caractéristique directionnelle désirée
• B64G 1/66 - Aménagements ou adaptations d'appareils ou d'instruments, non prévus ailleurs
• H01Q 1/44 - ANTENNES, c. à d. ANTENNES RADIO - Détails de dispositifs associés aux antennes utilisant un équipement ayant une autre fonction principale servant en outre d'antenne
• H01Q 21/22 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles les unités d'antennes du réseau étant excitées d'une façon non uniforme en amplitude ou en phase, p.ex. réseau à prises ou réseau bidirectionnel

Abrégé

Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects.

Classes IPC  ?

• A61K 31/47 - Quinoléines; Isoquinoléines
• A61P 33/06 - Antipaludéens

Abrégé

Cold spray devices and systems are disclosed. They include a flowpath having an inlet adapted for receiving communication with two or more inputs and an outlet adapted to discharge the two or more inputs. A discharge nozzle may be included in the flowpath of the outlet and a confluence may be included in the flowpath at the inlet for combining the two or more inputs. A nozzle body houses the discharge nozzle separate and downstream from the confluence of the two inputs.

Classes IPC  ?

• B05B 7/14 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides provenant de plusieurs sources, p.ex. un liquide et de l'air, une poudre et un gaz agencés pour projeter des matériaux en particules
• B05D 1/12 - Application de matériaux en particules

Abrégé

ABSTRACT A pre-fabricated tourniquet that is easy to apply, that ensures consistent and even circumferential pressure, that is light weight, that provides standard life saving operation, and that can be utilized in any setting or situation, and related methods are provided. Mechanically constricting tourniquet apparatus and related methods are provided that are comprised of a tourniquet body, a carriage, a torsion bar, a receiver and a slider. The tourniquet is long enough to encircle a human limb, for example, an arm or leg. Date recue/Date received 2023-09-27

Classes IPC  ?

• A61B 17/132 - Tourniquets
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets

Abrégé

A pre-fabricated tourniquet that is easy to apply, that ensures consistent and even circumferential pressure, that is light weight, that provides standard life saving operation, and that can be utilized in any setting or situation, and related methods are provided. Mechanically constricting tourniquet apparatus and related methods are provided that are comprised of a tourniquet body, a carriage, a torsion bar, a receiver and a slider. The tourniquet is long enough to encircle a human limb, for example, an arm or leg.

Classes IPC  ?

• A61B 17/132 - Tourniquets

Abrégé

A method and a system of estimating core temperatures of battery cells in a battery pack can include several steps. In one step, a surface temperature of one or more battery cell(s) is received, a current of the one or more battery cell(s) is received, an inlet temperature of coolant provided to the battery pack is received, and a flow rate or velocity of the coolant is received. In another step, estimations are made including those of a cell-lumped internal electrical resistance of the battery cell(s), a cell-lumped conduction resistance between a core and a surface of the battery cell(s), and a cell- lumped convection resistance between the surface and the coolant. In yet another step, an estimation is made of a core temperature of the battery cell(s) based upon the received and estimated values of previous steps.

Classes IPC  ?

• H01M 10/48 - Accumulateurs combinés à des dispositions pour mesurer, tester ou indiquer l'état des éléments, p.ex. le niveau ou la densité de l'électrolyte

Abrégé

A cementitious armor panel assembly including cementitious armor panel with ballistic and blast resistant properties attached to a frame structure to produce a protective structure. The cementitious armor panels have a continuous phase resulting from the curing of an aqueous mixture of an inorganic cement binder, an inorganic mineral filler having a particle size of about 150-450 microns, a pozzolanic mineral filler, a polycarboxylate based super- plasticizer self-leveling agent, and water. The mixture may also contain alkanolamine, and acid or acid salt. Prior to curing, the continuous phase is reinforced with fiber uniformly distributed in the continuous phase before it is cured to form the panel. The panel may be reinforced with a skin attached to at least one surface of the panel.

Classes IPC  ?

• F41H 5/04 - Structure des plaques composées de plus d'une couche
• C04B 28/28 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates contenant des polyacides organiques, p.ex. contenant des ciments de polycarboxylates
• F41H 5/02 - Structure des plaques

Abrégé

A cementitious panel with ballistic and blast resistant properties having a core layer of ultra-high compressive strength composite and at least one skin layer. The panels can also be used in walls, ceiling and flooring panels which require high compressive strength for resistance to earthquakes and surfaces resistant to surface abuse such as in prison and other institutions. The panel core layer has a continuous cementitious phase resulting from the curing of an aqueous mixture, in the absence of silica flour, of inorganic cement binder, inorganic mineral filler having a particle size of about 150-450 microns, a pozzolanic mineral filler, polycarboxylate based superplasticizer, alkanolamine and acid or alkali metal acid salt; and water. The mixture may be uniformly reinforced with fiber added before curing. The cementitious core layer is then reinforced with the skin, such as fiber reinforced polymer, attached to at least one panel surface.

Classes IPC  ?

• F41H 5/04 - Structure des plaques composées de plus d'une couche
• B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
• B32B 13/12 - Produits stratifiés composés essentiellement d'une substance à prise hydraulique, p.ex. du béton, du plâtre, du ciment, ou d'autres matériaux entrant dans la construction comprenant une telle substance comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
• B32B 13/14 - Produits stratifiés composés essentiellement d'une substance à prise hydraulique, p.ex. du béton, du plâtre, du ciment, ou d'autres matériaux entrant dans la construction adjacente à une couche fibreuse ou filamenteuse

Abrégé

A self-leveling cementitious mixture with excellent flow properties and which hardens with a controlled rate of strength development to an ultra-high compressive strength composite composition for use in making articles such as cementitious armor panel with ballistic and blast resistant properties including: a continuous phase resulting from the curing of an aqueous mixture, in the absence of silica flour, of inorganic cement binder, inorganic mineral filler having a particle size of about 150-450 microns, pozzolanic mineral filler, polycarboxylate based self-leveling agent and water. The cementitious mixture may include alkanolamine, such as thethanolamine, and acid or acid salt, such as tartaric acid. The cementitious composition may be reinforced with reinforcing fibers, e.g. glass fibers, in an amount of about 0.5 - 6.0 % by volume of the overall cementitious composition. The fibers are uniformly dispersed in the cementitious composition before it is cured to form a final cementitious armor panel.

Classes IPC  ?

• C04B 28/00 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates
• C04B 14/02 - Matières granuleuses
• C04B 14/38 - Matières fibreuses; "Whiskers"

Abrégé

A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc form or in a tablet, pill, etc form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.

Classes IPC  ?

• A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
• A62D 3/30 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par réaction avec des agents chimiques
• A01N 37/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant le groupe ; Leurs thio-analogues
• A01P 1/00 - Désinfectants; Composés antimicrobiens ou leurs mélanges
• C11D 3/20 - Composés organiques contenant de l'oxygène

Abrégé

A system for simulating one or more hemorrhages in order to provide a more dynamic and realistic hemorrhage simulation in order to train medical personnel and other critical care givers, such as first responders, medics, and emergency medical technicians (EMTs) on treating hemorrhages. The system includes a reservoir, a flow controller, and at least one conduit connected to at least one simulated wound site wherein the system supplies fluid to the simulated wound site in order to simulate a hemorrhage. The system may further include a plurality of wound sites that have their respective fluid flows controlled by the fluid flow controller. In at least one embodiment, the reservoir and the flow controller are housed within a bag. In at least one embodiment, the system further includes an audio system for providing audio cues to the simulation participants to enhance the realism of the simulation.

Classes IPC  ?

• G09B 23/30 - Modèles anatomiques

Abrégé

ABSTRACT A chirp transform correlator in which asynchronous operation is made possible by the use of a pair of paralleled signal process- ing channels to which the unknown signal to be correlated is applied. The two channels include sweeping local oscillators which are interlaced in timing so that any arbitrarily timed unknown input signal will be fully transformed by one or the other of said channels.

Classes IPC  ?

• G06G 7/19 - Dispositions pour l'exécution d'opérations de calcul, p.ex. amplificateurs spécialement adaptés à cet effet pour l'analyse ou la synthèse de fonctions en utilisant des fonctions orthogonales
• G01S 13/04 - Systèmes déterminant la présence d'une cible

Abrégé

ABSTRACT Doppler radar sets of the type including circuitry for determining and displaying sense of target motion along the radar beam. The Doppler phase shifters in the I and Q channels of pulse radars of this type are designed to operate at frequencies much higher than the Doppler baseband frequencies by selecting one of the Doppler sidebands of the radar's pulse repetition frequency, or one of the sidebands of a harmonic of such pulse repetition frequency, for application to said Doppler phase shifters. The higher operating frequency simplifies the design and construction of the Doppler phase shifters.

Classes IPC  ?

• G01S 13/62 - Détermination du sens d'un mouvement

Abrégé

Abstract of the Disclosure The power supply potential applied to the final stage of an RF amplifier is modulated by means of an adaptive power supply. The power supply potential applied to the final RF amplifier is controlled by a first control loop in accordance with an error signal derived from a comparison of a signal cor- responding to the weighted sum of the magnitude of the supply voltage applied and the current drawn by the final amplifier and the amplitude of the modulating signal. Additionally, an automatic level control circuit controls the level of the RF output signal in a second control loop in accordance with a comparison between the magnitude of the RF output of the amplifier and the amplitude of the modulating signal.

Classes IPC  ?

• H03G 3/20 - Commande automatique
• H03C 1/00 - Modulation d'amplitude

Abrégé

ABSTRACT A Y-junction dielectric waveguide circulator is provided with a dielectric support plate. At the vertex of adjacent dielectric waveguides are positioned metal tuning legs. These tuning legs are spaced from the waveguides and extend higher than them. Preferably the tuning legs are made integral with a cap positioned above the circulator junction. This cap also serves as a holder for the upper biasing magnet. The lower magnet is centered under the junction and bonded to the bottom of the support plate.

Classes IPC  ?

• H01P 1/383 - Circulateurs à jonction, p.ex. circulateurs en Y

Abrégé

ABSTRACT A dielectric waveguide of rectangular cross-section has periodically spaced, transverse slots in its upper surface. When traveling waves of varying millimeter wavelength frequencies are applied to the waveguide, the slots perturb the waves resulting in radiation having a main lobe that scans as the frequency changes. The antenna is made rigid by the use of a dielectric support.

Classes IPC  ?

• H01Q 3/22 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier l'orientation suivant la variation de fréquence de l'onde rayonnée
• H01Q 13/28 - Antennes constituées par un guide non résonnant à ondes de fuite ou une ligne de transmission; Structures équivalentes produisant un rayonnement le long du trajet de l'onde guidée comportant des éléments présentant des discontinuités électriques et espacées dans la direction de la propagation de l'onde, p.ex. élément diélectrique ou élément conducteur formant diélectrique artificiel

Abrégé

Abstract of the Disclosure A shaped charge warhead comprises a fragmenting wall defining a space which contains a shaped charge liner that is conical in shape having a large diameter base. The space between the liner and wall is filled with high explosive with a portion of the space adjacent the liner base being disposed by a support ring which interconnects the liner base with the wall. The reduc- tion of explosive near the line of base and the provision of the supporting ring improves the velocity configuratlon of a jet formed by the exploding warhead in that the velocity of the jet tail is reduced with respect to the velocity of the jet tip. The jet thus formed has increased an attrition capacity for antimaterial purposes.

Classes IPC  ?

• F42D 3/00 - Applications particulières de techniques de sautage