PRODUCTION OF MHC II/CII COMPLEXES

Registre Brevet WIPO
Numéro d'application EP2020072287
Numéro de publication 2021/028350
Statut Délivré - en vigueur
Date de dépôt 2020-08-07
Date de publication 2021-02-18
Propriétaire FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Allemagne)
Inventeur(s)
  • Schneider, Dr. Nadine
  • Xu, Bingze
  • Cienciala, Sylvia
  • Holmdahl, Prof. Rikard
  • Burkhardt, Prof. Dr. Harald

Abrégé

[142] The present invention relates to in situ glycosylated MHC II/CII peptide complexes, i.e., complexes naturally glycosylated during recombinant protein expression in the host cell. The invention further relates to methods of producing glycosylated MHC II/CII peptide complexes in mammalian cells. Furthermore the invention relates to the use of such post-translationally modified, preferably glycosylated MHC/CII complexed for use in treating rheumatoid arthritis, preferably in humans.

Classes IPC  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • A61P 37/00 - Drugs for immunological or allergic disorders